Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR51A4 OR51S1 OR2A25 ADGRF5 OR10AG1 GPR19 OR5D18	3.37e-04	884	31	7	GO:0004930
GeneOntologyMolecularFunction	olfactory receptor activity	OR51A4 OR51S1 OR2A25 OR10AG1 OR5D18	4.89e-04	431	31	5	GO:0004984
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR51A4 OR51S1 OR2A25 ADGRF5 OR10AG1 GPR19 PTPRD OR5D18	8.41e-04	1353	31	8	GO:0004888
Domain	Olfact_rcpt	OR51A4 OR51S1 OR2A25 OR10AG1 OR5D18	4.35e-04	393	31	5	IPR000725
Domain	GPCR_Rhodpsn_7TM	OR51A4 OR51S1 OR2A25 OR10AG1 GPR19 OR5D18	7.12e-04	670	31	6	IPR017452
Domain	7tm_1	OR51A4 OR51S1 OR2A25 OR10AG1 GPR19 OR5D18	7.52e-04	677	31	6	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR51A4 OR51S1 OR2A25 OR10AG1 GPR19 OR5D18	8.00e-04	685	31	6	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR51A4 OR51S1 OR2A25 OR10AG1 GPR19 OR5D18	8.37e-04	691	31	6	PS50262
Domain	GPCR_Rhodpsn	OR51A4 OR51S1 OR2A25 OR10AG1 GPR19 OR5D18	8.44e-04	692	31	6	IPR000276
Domain	FERM_N	FERMT2 FRMD3	1.36e-03	33	31	2	IPR018979
Domain	FERM_N	FERMT2 FRMD3	1.36e-03	33	31	2	PF09379
Domain	FERM_M	FERMT2 FRMD3	2.64e-03	46	31	2	PF00373
Domain	FERM_central	FERMT2 FRMD3	2.99e-03	49	31	2	IPR019748
Domain	FERM_domain	FERMT2 FRMD3	2.99e-03	49	31	2	IPR000299
Domain	-	FERMT2 FRMD3	2.99e-03	49	31	2	1.20.80.10
Domain	FERM_1	FERMT2 FRMD3	3.11e-03	50	31	2	PS00660
Domain	FERM_2	FERMT2 FRMD3	3.11e-03	50	31	2	PS00661
Domain	Band_41_domain	FERMT2 FRMD3	3.11e-03	50	31	2	IPR019749
Domain	B41	FERMT2 FRMD3	3.11e-03	50	31	2	SM00295
Domain	FERM/acyl-CoA-bd_prot_3-hlx	FERMT2 FRMD3	3.11e-03	50	31	2	IPR014352
Domain	FERM_3	FERMT2 FRMD3	3.11e-03	50	31	2	PS50057
Domain	Ig_I-set	ADGRF5 SIGLEC11 PTPRD	3.78e-03	190	31	3	IPR013098
Domain	ig	ADGRF5 SIGLEC11 PTPRD	3.78e-03	190	31	3	PF00047
Domain	Immunoglobulin	ADGRF5 SIGLEC11 PTPRD	3.78e-03	190	31	3	IPR013151
Domain	I-set	ADGRF5 SIGLEC11 PTPRD	3.78e-03	190	31	3	PF07679
Domain	IGc2	ADGRF5 SIGLEC11 PTPRD	6.82e-03	235	31	3	SM00408
Domain	Ig_sub2	ADGRF5 SIGLEC11 PTPRD	6.82e-03	235	31	3	IPR003598
Pubmed	KDM6A point mutations cause Kabuki syndrome.	SMARCA4 KDM6A	7.69e-07	2	31	2	23076834
Pubmed	SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade.	SMARCA4 KDM6A	2.31e-06	3	31	2	34262032
Pubmed	Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression.	SMARCA4 KDM6A	1.15e-05	6	31	2	21095589
Pubmed	Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts.	SMARCA4 ETV6	1.15e-05	6	31	2	24220145
Pubmed	A genomic analysis of mouse models of breast cancer reveals molecular features of mouse models and relationships to human breast cancer.	SMARCA4 ETV6	2.15e-05	8	31	2	25069779
Pubmed	UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development.	SMARCA4 KDM6A	2.76e-05	9	31	2	23028370
Pubmed	UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program.	SMARCA4 KDM6A	5.96e-05	13	31	2	22192413
Pubmed	Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway.	SMARCA4 ZMAT3	1.60e-04	21	31	2	20460684
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR51S1 OR2A25 OR10AG1 OR5D18	2.29e-04	340	31	4	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR51S1 OR2A25 OR10AG1 OR5D18	2.29e-04	340	31	4	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR51S1 OR2A25 OR10AG1 OR5D18	2.37e-04	343	31	4	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR51S1 OR2A25 OR10AG1 OR5D18	2.45e-04	346	31	4	14611657
Pubmed	Identification and Functional Characterization of a Novel Androgen Receptor Coregulator, EAP1.	SMARCA4 KDM6A	5.87e-04	40	31	2	34585037
Pubmed	Congenital Diaphragmatic Hernia Overview	SMARCA4 KDM6A	7.77e-04	46	31	2	20301533
Pubmed	The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.	ETV6 SLC7A4 PTPRD	8.85e-04	212	31	3	19521566
Cytoband	11q11	OR10AG1 OR5D18	4.68e-04	47	31	2	11q11
Cytoband	Ensembl 112 genes in cytogenetic band chr11q12	OR10AG1 VWCE OR5D18	1.62e-03	345	31	3	chr11q12
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	ADGRF5 SIGLEC11 PTPRD	9.42e-04	161	22	3	593
GeneFamily	Olfactory receptors, family 51	OR51A4 OR51S1	1.30e-03	44	22	2	164
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	FERMT2 FRMD3	1.67e-03	50	22	2	1293
GeneFamily	Fibronectin type III domain containing	TRIM67 PTPRD	1.60e-02	160	22	2	555
Disease	Leukemia, Myelomonocytic, Chronic	ETV6 KDM6A	1.21e-05	6	27	2	C0023480
Disease	partial epilepsy	PTPRD SLC33A1	1.09e-04	17	27	2	EFO_0004263
Disease	FEV change measurement, response to zileuton	LMBRD1 CYP21A2	2.39e-04	25	27	2	EFO_0005921, EFO_0007676
Disease	Burkitt Lymphoma	SMARCA4 ETV6	4.98e-04	36	27	2	C0006413
Disease	Parkinson disease, disease progression measurement	GPR19 PTPRD	5.85e-04	39	27	2	EFO_0008336, MONDO_0005180
Disease	BMI-adjusted waist-hip ratio, sex interaction measurement	PTPRD FERMT2	7.11e-04	43	27	2	EFO_0007788, EFO_0008343
Disease	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	SMARCA4 KDM6A	1.08e-03	53	27	2	C1961099
Disease	monoclonal gammopathy	PTPRD CYP21A2	1.08e-03	53	27	2	EFO_0000203
Disease	susceptibility to mononucleosis measurement	FAM47A PTPRD	1.82e-03	69	27	2	EFO_0008403
Disease	metabolite measurement, diet measurement	SMARCA4 CYP21A2	1.93e-03	71	27	2	EFO_0004725, EFO_0008111
Disease	electroencephalogram measurement	FAM47A PTPRD	2.09e-03	74	27	2	EFO_0004357
Disease	behavioural disinhibition measurement	TRIM67 CYP21A2	2.15e-03	75	27	2	EFO_0006946

Protein segments in the cluster

Peptide	Gene	Start	Entry
ALLAVPMVPLQIILP	SLC33A1	346	O00400
PMVPLQIILPLIISK	SLC33A1	351	O00400
KPHLIIPTLLVPLQN	GPR19	11	Q15760
LMPLAKQQPIISLQP	ATF6	211	P18850
QIPMVPLIPALSIVL	SLC7A4	541	O43246
LIVIIKINPKLHTPM	OR5D18	46	Q8NGL1
RVPSKIQLIAMQPIP	KIAA1549	1481	Q9HCM3
MIPPLLLNVRPHHKI	NSUN2	166	Q08J23
IQLMPSPIMHPLILN	ETV6	266	P41212
IILLIKIHPALQTPM	OR10AG1	36	Q8NH19
PLNMLLPLLQTVFPL	LMBRD1	351	Q9NUN5
LLVNHKPSPQIIPSM	KDM6A	871	O15550
LQPLPHCSVILKMQP	CYP21A2	461	P08686
PMILLALINHPELPI	OR51S1	261	Q8NGJ8
LMANVLLLVPPLTNP	OR51A4	276	Q8NGJ6
LALPMLVLLPQVIPA	DEFB118	6	Q96PH6
DNKSPLHLVQMPPVI	PI4K2A	436	Q9BTU6
KQLIINMEPLQPLLP	FRMD3	371	A2A2Y4
LENLHLPLPLLQPLM	CSN2	136	P05814
MPPDLLLQVLKHLDP	FAM47A	141	Q5JRC9
LKMQHLNPDPQLIPE	FERMT2	496	Q96AC1
TVPQMLANLLHPAKP	OR2A1;	76	Q8NGT9
TVPQMLVNLLHPAKP	OR2A25	76	A4D2G3
INIPLLPMEQLIVPA	PTPRD	961	P23468
PMVPLHQKQSRITPI	SMARCA4	341	P51532
QLITMPLPHIPLKNI	SPATA16	106	Q9BXB7
IVHPLPLKLNIMVDP	ADGRF5	561	Q8IZF2
IQMKCRVPPVPLLQL	TRIM67	506	Q6ZTA4
MTHLKINLPVTALPP	ZWILCH	121	Q9H900
LLLPHIPPMVASLVK	USP35	346	Q9P2H5
QPRQHPSKMLLLLPE	VWCE	276	Q96DN2
MILLQHAVLPPPKQP	ZMAT3	1	Q9HA38
AQPQSPEMLLLPLLL	SIGLEC11	6	Q96RL6