Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	satellite DNA binding	MBD2 MLH3	6.31e-06	4	21	2	GO:0003696
MousePheno	abnormal female meiosis	ZCCHC8 MEIOSIN SPATA22 MLH3	3.48e-06	84	18	4	MP:0005168
MousePheno	abnormal oogenesis	ZCCHC8 MEIOSIN SPATA22 MLH3	8.02e-05	186	18	4	MP:0001931
MousePheno	abnormal lymph circulation	PPP1R13B PROX1	1.03e-04	12	18	2	MP:0003659
MousePheno	abnormal ovarian follicle number	ZCCHC8 MEIOSIN SPATA22 TNFAIP3	1.13e-04	203	18	4	MP:0008871
MousePheno	abnormal meiosis	ZCCHC8 MEIOSIN SPATA22 MLH3	2.18e-04	241	18	4	MP:0001930
MousePheno	abnormal ovarian follicle morphology	ZCCHC8 MEIOSIN SPATA22 TNFAIP3	2.32e-04	245	18	4	MP:0001131
MousePheno	abnormal cell differentiation	NRG1 ZCCHC8 MEIOSIN SPATA22 MLH3 CCDC88A	3.41e-04	795	18	6	MP:0005076
MousePheno	abnormal superior vagus ganglion morphology	NRG1 DNM2	3.90e-04	23	18	2	MP:0001101
MousePheno	abnormal postnatal subventricular zone morphology	RAB23 CCDC88A	4.25e-04	24	18	2	MP:0004275
Domain	HMG_box_dom	MEIOSIN PROX1	2.40e-03	65	21	2	IPR009071
Pubmed	Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin.	CCDC88A DNM2	3.82e-07	2	22	2	25061227
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	ZCCHC8 RBM34 DNM2 FYTTD1 CENPQ	3.01e-06	370	22	5	22922362
Pubmed	Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos.	PPP1R13B PROX1	1.37e-05	9	22	2	18304521
Pubmed	Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model.	NRG1 PROX1	3.46e-05	14	22	2	24101523
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	MBD2 ZCCHC8 PROX1	3.73e-05	103	22	3	32744500
Pubmed	Platelets play an essential role in murine lung development through Clec-2/podoplanin interaction.	PPP1R13B PROX1	3.99e-05	15	22	2	29853539
Pubmed	A Y2H-seq approach defines the human protein methyltransferase interactome.	JMJD1C KMT5A SPATA22 CENPQ	5.84e-05	342	22	4	23455924
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	ZCCHC8 RBM34 DCP2 FYTTD1	7.44e-05	364	22	4	24778252
Pubmed	Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines.	NRG1 PROX1	7.96e-05	21	22	2	27348588
Pubmed	Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.	NBPF3 JMJD1C	7.96e-05	21	22	2	18940312
Pubmed	Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.	NRG1 TNFAIP3	8.76e-05	22	22	2	23247143
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	MBD2 ZCCHC8 INTS1	1.05e-04	146	22	3	23892456
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZCCHC8 JMJD1C CCDC88A PROX1	1.27e-04	418	22	4	34709266
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	MBD2 ZCCHC8 JMJD1C	1.57e-04	167	22	3	20362541
Pubmed	The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta.	ZCCHC8 KMT5A	3.56e-04	44	22	2	20178780
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	JMJD1C KMT5A	4.41e-04	49	22	2	34368113
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	NRG1 DNM2 FYTTD1 INTS1	4.47e-04	582	22	4	20467437
Pubmed	Functional proteomics mapping of a human signaling pathway.	PPP1R13B ZCCHC8 TNFAIP3 DNM2	4.73e-04	591	22	4	15231748
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	PPP1R13B CCDC88A DNM2	5.17e-04	251	22	3	29778605
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	JMJD1C KMT5A RBM34 INTS1	5.27e-04	608	22	4	36089195
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	PPP1R13B JMJD1C CCDC88A	5.92e-04	263	22	3	34702444
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	MBD2 ZCCHC8 JMJD1C	6.25e-04	268	22	3	33640491
Cytoband	12q24.31	ZCCHC8 KMT5A	6.77e-04	80	22	2	12q24.31
Disease	alkaline phosphatase measurement, liver enzyme measurement	NBPF3 JMJD1C	7.22e-06	6	21	2	EFO_0004533, EFO_0004582
Disease	fetuin-B measurement	NRG1 JMJD1C	2.16e-05	10	21	2	EFO_0008128
Disease	gastrin-releasing peptide measurement	NRG1 JMJD1C	2.64e-05	11	21	2	EFO_0022000
Disease	Alzheimer disease, educational attainment	MEIOSIN JMJD1C KMT5A	6.89e-04	247	21	3	EFO_0011015, MONDO_0004975
Disease	rheumatoid arthritis, ACPA-positive rheumatoid arthritis, rheumatoid factor seropositivity measurement	RGS22 TNFAIP3	9.18e-04	63	21	2	EFO_0000685, EFO_0007791, EFO_0009459
Disease	respiratory symptom measurement, COVID-19	NRG1 RGS22	1.26e-03	74	21	2	EFO_0007939, MONDO_0100096
Disease	psoriasis, type 2 diabetes mellitus	TNFAIP3 PROX1	1.30e-03	75	21	2	EFO_0000676, MONDO_0005148
Disease	Ischemic stroke	NRG1 DNM2 CENPQ	1.51e-03	324	21	3	HP_0002140
Disease	visual epilepsy (biomarker_via_orthology)	MBD2 NRG1	1.86e-03	90	21	2	DOID:11832 (biomarker_via_orthology)
Disease	malaria	NRG1 TNFAIP3	2.38e-03	102	21	2	EFO_0001068
Disease	tyrosine measurement	NRG1 JMJD1C	2.47e-03	104	21	2	EFO_0005058
Disease	pneumonia, COVID-19	NRG1 RGS22	2.91e-03	113	21	2	EFO_0003106, MONDO_0100096
Disease	red blood cell density measurement	MBD2 NRG1 JMJD1C PROX1	3.14e-03	880	21	4	EFO_0007978
Disease	colorectal cancer (is_implicated_in)	MLH3 TNFAIP3	3.33e-03	121	21	2	DOID:9256 (is_implicated_in)
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Positive	NRG1 JMJD1C	3.89e-03	131	21	2	C4704862
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Negative	NRG1 JMJD1C	3.89e-03	131	21	2	C4552091
Disease	Juvenile arthritis	NRG1 JMJD1C	3.89e-03	131	21	2	C3495559
Disease	Juvenile psoriatic arthritis	NRG1 JMJD1C	3.89e-03	131	21	2	C3714758
Disease	Juvenile-Onset Still Disease	NRG1 JMJD1C	4.12e-03	135	21	2	C0087031

Protein segments in the cluster

Peptide	Gene	Start	Entry
NASKKNAQQLKRNPK	CENPQ	6	Q7L2Z9
NAQQLKRNPKRKKDN	CENPQ	11	Q7L2Z9
NQKKRTNGLQPAKQQ	DCP2	331	Q8IU60
NSKLQQQKELLNKRN	PPP1R13B	286	Q96KQ4
NLRPNKQRTKKNRNP	RAB23	216	Q9ULC3
QNSNPRLKNVSKPKQ	RBM34	371	P42696
FKNGNELNRKNKPQN	NRG1	71	Q02297
QAPRKKAQGKTQQNR	KMT5A	206	Q9NQR1
QKAKKRQRQQKQRQL	INTS1	936	Q8N201
HQQQQQRSIRPNKRK	JMJD1C	301	Q15652
NPKLESQRVNKKVNN	CCDC88A	56	Q3V6T2
ILKNNRIQNQPKRFK	MLH3	541	Q9UHC1
QRSTQLNKKRAIPNQ	DNM2	501	P50570
GKLRNQRNQNKLLSP	MEIOSIN	56	C9JSJ3
QRNQNKLLSPNKKQR	MEIOSIN	61	C9JSJ3
SKLQKNKQRLRNDPL	MBD2	216	Q9UBB5
NKQRLRNDPLNQNKG	MBD2	221	Q9UBB5
INKKSRPQLAENKQQ	NBPF3	76	Q9H094
RPQLAENKQQFRNLK	NBPF3	81	Q9H094
LFNQKKRNRQPLTSN	SPATA22	21	Q8NHS9
KQLKKILQNQQPRNP	RGS22	66	Q8NE09
ENKRKQKLPQQQQQS	PROX1	206	Q92786
VNQQIRLRKKQQLQK	CCDC15	91	Q0P6D6
KKQNFPRLNRRLLQQ	FYTTD1	46	Q96QD9
LLKNSPRNQQKNKKA	ZCCHC8	691	Q6NZY4
RQKNQNKLPKLNSKP	TNFAIP3	411	P21580