Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	PRAMEF9 TCERG1L ANK3 PRAMEF15 RAPGEF4 MAML1 PEX6 GOLPH3 PRAMEF4 RAD54L2 STAT3 LDB2 NUFIP1 FBXO38 MRTFB LDB1 PKM NCOA7 PRAMEF27 PRAME NOTCH1 MRTFA	8.16e-06	1160	133	22	GO:0030674
GeneOntologyMolecularFunction	molecular adaptor activity	PRAMEF9 TCERG1L ANK3 PRAMEF15 RAPGEF4 MAML1 PEX6 GOLPH3 PRAMEF4 RAD54L2 STAT3 TAB3 LDB2 NUFIP1 FBXO38 MRTFB LDB1 TELO2 PKM NCOA7 PRAMEF27 PRAME NOTCH1 MRTFA	9.59e-06	1356	133	24	GO:0060090
GeneOntologyMolecularFunction	ubiquitin-like ligase-substrate adaptor activity	PRAMEF9 PRAMEF15 PRAMEF4 FBXO38 PRAMEF27 PRAME	1.80e-05	82	133	6	GO:1990756
GeneOntologyMolecularFunction	protein kinase binding	KIF13B BCL2L11 DSCAM ROR2 MAML1 CASP9 TNIP1 RAD54L2 TESK1 STAT3 RYR2 TELO2 NBEAL2 CDK5RAP1 KCNQ1 TRPV4 TAOK1 MAP4K2	1.99e-05	873	133	18	GO:0019901
GeneOntologyMolecularFunction	kinase binding	KIF13B BCL2L11 DSCAM ROR2 MAML1 CASP9 TNIP1 DGKD RAD54L2 TESK1 STAT3 RYR2 TELO2 NBEAL2 CDK5RAP1 KCNQ1 TRPV4 TAOK1 MAP4K2	2.30e-05	969	133	19	GO:0019900
GeneOntologyMolecularFunction	enzyme-substrate adaptor activity	PRAMEF9 PRAMEF15 PRAMEF4 FBXO38 PRAMEF27 PRAME	4.17e-05	95	133	6	GO:0140767
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	PRAMEF15 PRAMEF4 PRAMEF27 PRAME	4.93e-04	55	133	4	GO:0042974
GeneOntologyMolecularFunction	helicase activity	SMARCA5 ERCC6 ZNFX1 RAD54L2 FBH1 CHTF18	6.70e-04	158	133	6	GO:0004386
GeneOntologyMolecularFunction	protein kinase activity	STK36 ROR2 TSSK2 TESK1 CLK3 PKM TAOK1 MAP3K21 MAP4K2 EPHA10 MAST3 CDK4	6.84e-04	600	133	12	GO:0004672
GeneOntologyMolecularFunction	protein serine kinase activity	STK36 TSSK2 TESK1 CLK3 TAOK1 MAP3K21 MAP4K2 MAST3 CDK4	7.40e-04	363	133	9	GO:0106310
GeneOntologyMolecularFunction	ATP hydrolysis activity	KIF13B SMARCA5 ERCC6 PEX6 ABCC5 RAD54L2 MDN1 FBH1 ABCC8 CHTF18	7.51e-04	441	133	10	GO:0016887
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	STK36 TSSK2 TESK1 CLK3 PKM TAOK1 MAP3K21 MAP4K2 MAST3 CDK4	8.19e-04	446	133	10	GO:0004674
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	STK36 ROR2 TSSK2 DGKD TESK1 CLK3 PKM TAOK1 MAP3K21 MAP4K2 EPHA10 MAST3 CDK4	9.14e-04	709	133	13	GO:0016773
GeneOntologyMolecularFunction	LIM domain binding	LDB2 LDB1	1.54e-03	9	133	2	GO:0030274
GeneOntologyMolecularFunction	nuclear receptor binding	PRAMEF15 PRAMEF4 STAT3 NCOA7 PRAMEF27 PRAME	1.60e-03	187	133	6	GO:0016922
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	SMARCA5 ERCC6 RAD54L2 FBH1 CHTF18	1.62e-03	127	133	5	GO:0008094
GeneOntologyMolecularFunction	kinase activity	STK36 ROR2 TSSK2 DGKD TESK1 CLK3 PKM TAOK1 MAP3K21 MAP4K2 EPHA10 MAST3 CDK4	1.79e-03	764	133	13	GO:0016301
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	SMARCA5 ERCC6 RAD54L2	1.90e-03	37	133	3	GO:0140658
GeneOntologyMolecularFunction	complement component C1q complex binding	C4A C4B	1.91e-03	10	133	2	GO:0001849
GeneOntologyMolecularFunction	primary miRNA binding	STAT3 PUS10	1.91e-03	10	133	2	GO:0070878
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	KIF13B SMARCA5 ERCC6 PEX6 ABCC5 RRAD RAD54L2 EFTUD2 MDN1 FBH1 ABCC8 CHTF18 ARL13B	2.02e-03	775	133	13	GO:0017111
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF27 PRAME	1.20e-05	47	133	5	GO:0031462
GeneOntologyCellularComponent	B-WICH complex	SMARCA5 ERCC6 SF3B1	1.38e-05	8	133	3	GO:0110016
GeneOntologyCellularComponent	MAML1-RBP-Jkappa- ICN1 complex	MAML1 NOTCH1	1.20e-04	3	133	2	GO:0002193
GeneOntologyCellularComponent	TTT Hsp90 cochaperone complex	TTI2 TELO2	1.20e-04	3	133	2	GO:0110078
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	PRAMEF9 PRAMEF15 PRAMEF4 FBXO38 FBH1 PRAMEF27 PRAME	4.23e-04	212	133	7	GO:0031461
Domain	PRAME_family	PRAMEF25 PRAMEF15 PRAMEF4 PRAMEF27 PRAME	1.63e-07	19	130	5	IPR026271
Domain	LIM-bd/SEUSS	LDB2 LDB1	4.81e-05	2	130	2	IPR029005
Domain	-	SMARCA5 ERCC6 GTPBP6 PEX6 ABCC5 ZNFX1 RRAD RAD54L2 EFTUD2 MDN1 FBH1 ABCC8 CHTF18 ARL13B CARD14	2.17e-04	746	130	15	3.40.50.300
Domain	P-loop_NTPase	KIF13B SMARCA5 ERCC6 GTPBP6 PEX6 ABCC5 ZNFX1 RRAD RAD54L2 EFTUD2 MDN1 FBH1 ABCC8 CHTF18 ARL13B CARD14	2.71e-04	848	130	16	IPR027417
Domain	PROTEIN_KINASE_ATP	STK36 ROR2 TSSK2 TESK1 CLK3 TAOK1 MAP3K21 MAP4K2 EPHA10 MAST3 CDK4	3.69e-04	459	130	11	PS00107
Domain	Anaphylatoxin_comp_syst	C4A C4B	4.74e-04	5	130	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	4.74e-04	5	130	2	IPR001840
Domain	ARM-type_fold	STK36 TTI2 PSMD5 ZNFX1 DOCK5 SF3B1 PELP1 TELO2 NBEAL2	6.18e-04	339	130	9	IPR016024
Domain	Prot_kinase_dom	STK36 ROR2 TSSK2 TESK1 CLK3 TAOK1 MAP3K21 MAP4K2 EPHA10 MAST3 CDK4	6.26e-04	489	130	11	IPR000719
Domain	PROTEIN_KINASE_DOM	STK36 ROR2 TSSK2 TESK1 CLK3 TAOK1 MAP3K21 MAP4K2 EPHA10 MAST3 CDK4	6.69e-04	493	130	11	PS50011
Domain	-	ETV6 DGKD PHC2 SAMD3 EPHA10	8.74e-04	106	130	5	1.10.150.50
Domain	ANATO	C4A C4B	9.87e-04	7	130	2	SM00104
Domain	STAT_TF_DNA-bd_sub	STAT3 STAT5A	9.87e-04	7	130	2	IPR012345
Domain	STAT	STAT3 STAT5A	9.87e-04	7	130	2	IPR001217
Domain	STAT_int	STAT3 STAT5A	9.87e-04	7	130	2	SM00964
Domain	RPEL	MRTFB MRTFA	9.87e-04	7	130	2	PS51073
Domain	STAT_TF_DNA-bd	STAT3 STAT5A	9.87e-04	7	130	2	IPR013801
Domain	STAT_bind	STAT3 STAT5A	9.87e-04	7	130	2	PF02864
Domain	STAT_int	STAT3 STAT5A	9.87e-04	7	130	2	PF02865
Domain	RPEL	MRTFB MRTFA	9.87e-04	7	130	2	SM00707
Domain	ANAPHYLATOXIN_2	C4A C4B	9.87e-04	7	130	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	9.87e-04	7	130	2	PS01177
Domain	-	STAT3 STAT5A	9.87e-04	7	130	2	1.10.532.10
Domain	STAT_alpha	STAT3 STAT5A	9.87e-04	7	130	2	PF01017
Domain	-	STAT3 STAT5A	9.87e-04	7	130	2	1.20.1050.20
Domain	STAT_TF_prot_interaction	STAT3 STAT5A	9.87e-04	7	130	2	IPR013799
Domain	STAT_TF_coiled-coil	STAT3 STAT5A	9.87e-04	7	130	2	IPR015988
Domain	-	STAT3 STAT5A	9.87e-04	7	130	2	2.60.40.630
Domain	ANATO	C4A C4B	9.87e-04	7	130	2	PF01821
Domain	RPEL	MRTFB MRTFA	9.87e-04	7	130	2	PF02755
Domain	RPEL_repeat	MRTFB MRTFA	9.87e-04	7	130	2	IPR004018
Domain	Anaphylatoxin/fibulin	C4A C4B	9.87e-04	7	130	2	IPR000020
Domain	STAT_TF_alpha	STAT3 STAT5A	1.31e-03	8	130	2	IPR013800
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	1.31e-03	8	130	2	IPR019565
Domain	Thiol-ester_cl	C4A C4B	1.31e-03	8	130	2	PF10569
Domain	MacrogloblnA2_CS	C4A C4B	1.31e-03	8	130	2	IPR019742
Domain	SAM/pointed	ETV6 DGKD PHC2 SAMD3 EPHA10	1.36e-03	117	130	5	IPR013761
Domain	SNF2_N	SMARCA5 ERCC6 RAD54L2	1.41e-03	32	130	3	IPR000330
Domain	SNF2_N	SMARCA5 ERCC6 RAD54L2	1.41e-03	32	130	3	PF00176
Domain	Kinase-like_dom	STK36 ROR2 TSSK2 TESK1 CLK3 TAOK1 MAP3K21 MAP4K2 EPHA10 MAST3 CDK4	1.44e-03	542	130	11	IPR011009
Domain	A2M	C4A C4B	2.09e-03	10	130	2	PF00207
Domain	A2M_N_2	C4A C4B	2.09e-03	10	130	2	IPR011625
Domain	A2M_comp	C4A C4B	2.09e-03	10	130	2	IPR011626
Domain	A2M_recep	C4A C4B	2.09e-03	10	130	2	PF07677
Domain	A2M_comp	C4A C4B	2.09e-03	10	130	2	PF07678
Domain	A2M_N	C4A C4B	2.09e-03	10	130	2	PF01835
Domain	A2M_N	C4A C4B	2.09e-03	10	130	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	2.09e-03	10	130	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	2.09e-03	10	130	2	PS00477
Domain	A2M_N_2	C4A C4B	2.09e-03	10	130	2	PF07703
Domain	Macroglobln_a2	C4A C4B	2.09e-03	10	130	2	IPR001599
Domain	ARM-like	STK36 TTI2 PSMD5 SF3B1 PELP1 TELO2 NBEAL2	2.85e-03	270	130	7	IPR011989
Domain	SAM	DGKD PHC2 SAMD3 EPHA10	3.33e-03	88	130	4	SM00454
Domain	AAA	PEX6 ABCC5 MDN1 ABCC8 CHTF18	3.36e-03	144	130	5	SM00382
Domain	AAA+_ATPase	PEX6 ABCC5 MDN1 ABCC8 CHTF18	3.36e-03	144	130	5	IPR003593
Domain	Ser/Thr_kinase_AS	STK36 TSSK2 CLK3 TAOK1 MAP3K21 MAP4K2 MAST3 CDK4	3.55e-03	357	130	8	IPR008271
Domain	S_TKc	STK36 TSSK2 CLK3 TAOK1 MAP3K21 MAP4K2 MAST3 CDK4	3.67e-03	359	130	8	SM00220
Domain	PROTEIN_KINASE_ST	STK36 TSSK2 CLK3 TAOK1 MAP3K21 MAP4K2 MAST3 CDK4	3.86e-03	362	130	8	PS00108
Domain	SAM_DOMAIN	DGKD PHC2 SAMD3 EPHA10	4.38e-03	95	130	4	PS50105
Domain	SAM	DGKD PHC2 SAMD3 EPHA10	4.71e-03	97	130	4	IPR001660
Domain	Protein_kinase_ATP_BS	STK36 TSSK2 TESK1 CLK3 TAOK1 MAP3K21 MAP4K2 CDK4	5.07e-03	379	130	8	IPR017441
Domain	Pkinase	STK36 TSSK2 TESK1 CLK3 TAOK1 MAP4K2 MAST3 CDK4	5.23e-03	381	130	8	PF00069
Domain	C345C	C4A C4B	6.11e-03	17	130	2	SM00643
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	6.84e-03	18	130	2	IPR008930
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	SMARCA5 ERCC6 ANK3 U2SURP RAPGEF4 CASP9 STAT5A MDN1 NBEAL2 CPSF1 TAOK1 C4A C4B CSPP1	1.07e-08	497	136	14	36774506
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	HIVEP2 ANK3 GTPBP6 DSCAM RAPGEF4 CEP57L1 ABCC5 PSMD5 ZNFX1 RAD54L2 SLC4A3 STAT3 ZBED5 LDB2 NUFIP1 SF3B1 FBH1 LDB1 ARL13B PKM TAOK1	3.03e-08	1285	136	21	35914814
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	SMARCA5 EPPK1 ERCC6 WNT10B SF3B1 CLK3 SLIT1 ARL13B PKM RPL3 NOTCH1	1.83e-07	358	136	11	32460013
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KIF13B HIVEP2 INPP5E ROR2 TSSK2 ITPRID2 TESK1 STAT3 TAB3 STOX2 MDN1 SBF1 CLK3 NCOA7 MAP3K21 CSPP1	2.85e-07	861	136	16	36931259
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	STK36 EPPK1 HIVEP2 GTPBP6 BCL2L11 INPP5E MAML1 PEX6 LAMA5 COMTD1 TESK1 PHC2 MDN1 SBF1 NBEAL2 CPSF1 WDR90 NOTCH1	3.39e-07	1105	136	18	35748872
Pubmed	Functional proteomics mapping of a human signaling pathway.	ERCC6 ANK3 PEX6 LAMA5 TNIP1 RYR2 ZBED5 LDB2 MRTFB SF3B1 LDB1 PELP1 CEP250	6.21e-07	591	136	13	15231748
Pubmed	The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells.	BCL2L11 STAT3 STAT5A	1.16e-06	6	136	3	23453633
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF15 PRAMEF4 PRAMEF27 PRAME	1.55e-06	22	136	4	31729367
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	SMARCA5 U2SURP PSMD5 STAT3 EFTUD2 GMPS SF3B1 CPSF1	2.65e-06	220	136	8	35785414
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF15 PRAMEF4 PRAMEF27 PRAME	2.65e-06	25	136	4	37451217
Pubmed	Distinct strategies to make nucleosomal DNA accessible.	SMARCA5 ERCC6 SF3B1	3.23e-06	8	136	3	12769854
Pubmed	Nuclear myosin 1 contributes to a chromatin landscape compatible with RNA polymerase II transcription activation.	SMARCA5 ERCC6 SF3B1	3.23e-06	8	136	3	26044184
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	SMARCA5 EFTUD2 GMPS FBXO38 SF3B1 MDN1 PELP1 CEP250	4.18e-06	234	136	8	36243803
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF15 PRAMEF4 PRAMEF27 PRAME	4.26e-06	28	136	4	25089626
Pubmed	Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression.	SMARCA5 ERCC6 SF3B1	4.83e-06	9	136	3	23555303
Pubmed	The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.	SMARCA5 ERCC6 SF3B1	4.83e-06	9	136	3	16603771
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	KIF13B ANK3 DSCAM RAPGEF4 RGPD1 ZNFX1 SPECC1L LDB2 EFTUD2 STOX2 SF3B1 MDN1 LDB1 SBF1 PELP1	5.94e-06	963	136	15	28671696
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	ERCC6 U2SURP DGKD PHC2 EFTUD2 DOCK5 SF3B1 PKM CPSF1 L3HYPDH RPL3	6.00e-06	513	136	11	25798074
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	EPPK1 RAD54L2 EFTUD2 FBXO38 SF3B1 MDN1 PELP1 PKM NUP160	6.84e-06	332	136	9	32786267
Pubmed	Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.	U2SURP STAT3 STAT5A GMPS SF3B1 LDB1 C4A	7.36e-06	180	136	7	30110629
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	STK36 EPPK1 ANK3 ITPRID2 RAD54L2 DOCK5 MRTFB WDR90 NOTCH1 MRTFA	8.00e-06	430	136	10	35044719
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	SMARCA5 U2SURP EFTUD2 INTS6 SF3B1 FBH1 PELP1 CHTF18 CPSF1	8.27e-06	340	136	9	24332808
Pubmed	JAK2, but not Src family kinases, is required for STAT, ERK, and Akt signaling in response to growth hormone in preadipocytes and hepatoma cells.	STAT3 STAT5A GH1	9.43e-06	11	136	3	18499741
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	EPPK1 ITPRID2 EFTUD2 SF3B1 TELO2 PKM RPL3 PRAME	1.01e-05	264	136	8	32814769
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF15 PRAMEF4 PRAMEF27 PRAME	1.07e-05	35	136	4	19389355
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	ANK3 DSCAM MAML1 ABCC5 SPECC1L RYR2 EFTUD2 DOCK5 SF3B1 ARL13B PKM RPL3 NUP160	1.22e-05	777	136	13	35844135
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	LAMA5 TNIP1 DGKD ITPRID2 RAD54L2 SLC22A17 PHC2 SLIT1 PKM RPL3 NOTCH1	1.36e-05	560	136	11	21653829
Pubmed	Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.	STAT3 MRTFB NOTCH1 MRTFA	1.49e-05	38	136	4	27930960
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	1.52e-05	2	136	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	1.52e-05	2	136	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	1.52e-05	2	136	2	15998580
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	1.52e-05	2	136	2	19062096
Pubmed	The Status of STAT3 and STAT5 in Human Breast Atypical Ductal Hyperplasia.	STAT3 STAT5A	1.52e-05	2	136	2	26146825
Pubmed	Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E.	INPP5E ARL13B	1.52e-05	2	136	2	27927754
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	1.52e-05	2	136	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	1.52e-05	2	136	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	1.52e-05	2	136	2	17645767
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	1.52e-05	2	136	2	12207352
Pubmed	Nuclear PKM2 contributes to gefitinib resistance via upregulation of STAT3 activation in colorectal cancer.	STAT3 PKM	1.52e-05	2	136	2	26542452
Pubmed	Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis.	STAT3 STAT5A	1.52e-05	2	136	2	15998795
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	1.52e-05	2	136	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	1.52e-05	2	136	2	22387014
Pubmed	STAT3 Impairs STAT5 Activation in the Development of IL-9-Secreting T Cells.	STAT3 STAT5A	1.52e-05	2	136	2	26976954
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	1.52e-05	2	136	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	1.52e-05	2	136	2	23918728
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	1.52e-05	2	136	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	1.52e-05	2	136	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	1.52e-05	2	136	2	4216347
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	1.52e-05	2	136	2	6950384
Pubmed	PKM2 promotes cell metastasis and inhibits autophagy via the JAK/STAT3 pathway in hepatocellular carcinoma.	STAT3 PKM	1.52e-05	2	136	2	33512635
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	1.52e-05	2	136	2	8660986
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	1.52e-05	2	136	2	8428773
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	1.52e-05	2	136	2	24638111
Pubmed	Nuclear accumulation of pyruvate kinase M2 promotes liver regeneration via activation of signal transducer and activator of transcription 3.	STAT3 PKM	1.52e-05	2	136	2	32198052
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	1.52e-05	2	136	2	21345967
Pubmed	Prognostic correlation of NOTCH1 and SF3B1 mutations with chromosomal abnormalities in chronic lymphocytic leukemia patients.	SF3B1 NOTCH1	1.52e-05	2	136	2	36411516
Pubmed	Tissue Profile of CDK4 and STAT3 as Possible Innovative Therapeutic Targets in Urinary Bladder Cancer.	STAT3 CDK4	1.52e-05	2	136	2	32102537
Pubmed	FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report.	STAT3 STAT5A	1.52e-05	2	136	2	23243289
Pubmed	Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes.	MAML1 NOTCH1	1.52e-05	2	136	2	20972443
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	1.52e-05	2	136	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	1.52e-05	2	136	2	2302180
Pubmed	PKM2 aggravates palmitate-induced insulin resistance in HepG2 cells via STAT3 pathway.	STAT3 PKM	1.52e-05	2	136	2	28802581
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	1.52e-05	2	136	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	1.52e-05	2	136	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	1.52e-05	2	136	2	29080553
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	1.52e-05	2	136	2	6589636
Pubmed	Myocardin related transcription factors are required for coordinated cell cycle progression.	MRTFB MRTFA	1.52e-05	2	136	2	23656782
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	1.52e-05	2	136	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	1.52e-05	2	136	2	17728371
Pubmed	Aberrantly low STAT3 and STAT5 responses are associated with poor outcome and an inflammatory gene expression signature in pediatric acute myeloid leukemia.	STAT3 STAT5A	1.52e-05	2	136	2	33948920
Pubmed	Structure and organization of the C4 genes.	C4A C4B	1.52e-05	2	136	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	1.52e-05	2	136	2	6149581
Pubmed	Reciprocal effects of STAT5 and STAT3 in breast cancer.	STAT3 STAT5A	1.52e-05	2	136	2	19491198
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	1.52e-05	2	136	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	1.52e-05	2	136	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	1.52e-05	2	136	2	2387317
Pubmed	MRTF-A/B suppress the oncogenic properties of v-ras- and v-src-mediated transformants.	MRTFB MRTFA	1.52e-05	2	136	2	20338973
Pubmed	Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence.	MRTFB MRTFA	1.52e-05	2	136	2	23853104
Pubmed	Prognostic impact of NOTCH1, MYD88, and SF3B1 mutations in Polish patients with chronic lymphocytic leukemia.	SF3B1 NOTCH1	1.52e-05	2	136	2	28424451
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	1.52e-05	2	136	2	16908004
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	1.52e-05	2	136	2	7365238
Pubmed	Spliced isoforms of LIM-domain-binding protein (CLIM/NLI/Ldb) lacking the LIM-interaction domain.	LDB2 LDB1	1.52e-05	2	136	2	16815859
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	1.52e-05	2	136	2	7391573
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	1.52e-05	2	136	2	17971360
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	1.52e-05	2	136	2	29928053
Pubmed	The MRTF-A/B function as oncogenes in pancreatic cancer.	MRTFB MRTFA	1.52e-05	2	136	2	26498848
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	1.52e-05	2	136	2	17971229
Pubmed	Notch1 induces epithelial-mesenchymal transition and the cancer stem cell phenotype in breast cancer cells and STAT3 plays a key role.	STAT3 NOTCH1	1.52e-05	2	136	2	25544568
Pubmed	Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes.	MRTFB MRTFA	1.52e-05	2	136	2	12944485
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	1.52e-05	2	136	2	6881182
Pubmed	MRTF-A and STAT3 synergistically promote breast cancer cell migration.	STAT3 MRTFA	1.52e-05	2	136	2	25038455
Pubmed	Chronic lymphocytic leukemia: a clinical and molecular heterogenous disease.	SF3B1 NOTCH1	1.52e-05	2	136	2	23531595
Pubmed	TROAP Promotes the Proliferation, Migration, and Metastasis of Kidney Renal Clear Cell Carcinoma with the Help of STAT3.	TROAP STAT3	1.52e-05	2	136	2	37298609
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	1.52e-05	2	136	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	1.52e-05	2	136	2	21880985
Pubmed	Myocardin-related transcription factors are required for skeletal muscle development.	MRTFB MRTFA	1.52e-05	2	136	2	27385017
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	1.52e-05	2	136	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	1.52e-05	2	136	2	35898513
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	1.52e-05	2	136	2	28873507
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	1.52e-05	2	136	2	276882
Interaction	FBXO22 interactions	SMARCA5 ERCC6 ANK3 U2SURP RAPGEF4 CASP9 STAT5A EFTUD2 MDN1 NBEAL2 CPSF1 TAOK1 C4A C4B CSPP1	2.38e-06	540	131	15	int:FBXO22
Interaction	BRCA1 interactions	SMARCA5 ERCC6 HECTD3 TROAP CEP57L1 ETV6 CASP9 ITPRID2 RAD54L2 STAT3 STAT5A NUFIP1 EFTUD2 GMPS FBXO38 SF3B1 MDN1 PKM MAP3K21 RPL3 PRAME NUP160 CDK4	5.29e-06	1249	131	23	int:BRCA1
Interaction	HSP90AA1 interactions	STK36 HECTD3 ROR2 TTI2 TSSK2 TNIP1 TESK1 STAT3 EFTUD2 DOCK5 FBXO38 FBH1 CLK3 CHTF18 CEP250 PKM C4A FGD5 MAP3K21 RPL3 MAP4K2 CDK4	2.07e-05	1263	131	22	int:HSP90AA1
Interaction	AR interactions	SMARCA5 EPPK1 U2SURP MAML1 PSMD5 ITPRID2 RAD54L2 STAT3 EFTUD2 GMPS SF3B1 MDN1 LDB1 PELP1 TELO2 PKM CPSF1 RPL3 PRAME	2.26e-05	992	131	19	int:AR
Cytoband	1p36.21	PRAMEF25 PRAMEF9 PRAMEF15 CASP9 PRAMEF4	1.30e-06	63	136	5	1p36.21
GeneFamily	PRAME family	PRAMEF25 PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF27 PRAME	1.31e-09	24	87	6	686
GeneFamily	TTT complex	TTI2 TELO2	6.85e-05	3	87	2	1320
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	8.06e-04	9	87	2	1234
GeneFamily	Sterile alpha motif domain containing	DGKD PHC2 SAMD3 EPHA10	8.57e-04	88	87	4	760
GeneFamily	ATP binding cassette subfamily C	ABCC5 ABCC8	1.72e-03	13	87	2	807
GeneFamily	AAA ATPases	PEX6 MDN1 CHTF18	2.12e-03	53	87	3	413
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DSCAM RYR2 LDB2 MRTFB SLIT1 KCNIP4 MAST3	1.63e-06	186	135	7	84ba666237c18189d7e7556bd92dd953af733c00
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DSCAM RYR2 LDB2 MRTFB SLIT1 KCNIP4 MAST3	2.02e-06	192	135	7	5c7e8b80b44d9ce55c797cdf8267ac5382e26cac
ToppCell	Neuronal-Excitatory\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DSCAM RYR2 LDB2 MRTFB SLIT1 KCNIP4 MAST3	2.64e-06	200	135	7	4409065bc7aa995354c71e0f9d6f3726cf393d6b
ToppCell	3'-Adult-Distal_Rectal-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KLK15 KIF13B GJC1 ANKRD36B DLEC1 CARD14	1.02e-05	162	135	6	075f73ff10e1a7f5695e014e47acc4db513e9cfb
ToppCell	Control-Epithelial_cells-ECM-high_epithelial\|Control / group, cell type (main and fine annotations)	ANK3 LAMA5 ADGRV1 LDB2 STOX2 NCOA7	1.34e-05	170	135	6	e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ERCC6 BCL2L11 VILL NBEAL2 CHTF18 ARHGAP45	1.58e-05	175	135	6	a3f8c54c77bce9b035a4835945ab341909be4946
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DSCAM RPP40 RAPGEF4 GJC1 LDB2 FGD5	1.63e-05	176	135	6	64e426f5e84884ce2c29acf6f4b958962a63927f
ToppCell	Control-Endothelial_cells-Pulmonary_venous_endothelial_cells\|Control / group, cell type (main and fine annotations)	RAPGEF4 LDB2 MRTFB ABCC8 KCNIP4 FGD5	2.03e-05	183	135	6	46be9f96755c7b65aeac061d95d15abeb6466034
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TCERG1L RYR2 LDB2 MRTFB KCNIP4 MAST3	2.36e-05	188	135	6	50c1b1d690f0e9443082f2adf4f1b8e9ce4cd337
ToppCell	COVID-19-lung-Vein_EC\|lung / Disease (COVID-19 only), tissue and cell type	RAPGEF4 LDB2 STOX2 MRTFB ABCC8 FGD5	2.36e-05	188	135	6	d582b76fc2faac526c9bf97503041129e1a6a211
ToppCell	COVID-19-kidney-VWF+PLVAP+VCAM1+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RAPGEF4 LDB2 STOX2 NCOA7 KCNIP4 FGD5	2.43e-05	189	135	6	c121817ddad164e9cfe382c43d0cbc9215508d02
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RYR2 LDB2 MRTFB SLIT1 KCNIP4 MAST3	2.43e-05	189	135	6	a75226616340045b581d08429d2e123e041dee55
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DSCAM RYR2 LDB2 MRTFB KCNIP4 MAST3	2.51e-05	190	135	6	d594da827e3c16644952b9589cc12b947ce36279
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DSCAM RYR2 LDB2 MRTFB KCNIP4 MAST3	2.51e-05	190	135	6	49e09cdb843b3d889a06a811aa5affae68b25a75
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF13B ANK3 ETV6 NBEAL2 KCNQ1 TRPV4	2.58e-05	191	135	6	3e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCell	droplet-Fat-Mat-18m-Endothelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAPGEF4 LAMA5 RYR2 LDB2 MRTFB FGD5	2.74e-05	193	135	6	54024a373e42e1c0bcc327dc084564b83b63a9d4
ToppCell	droplet-Fat-Mat-18m-Endothelial-endothelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAPGEF4 LAMA5 RYR2 LDB2 MRTFB FGD5	2.74e-05	193	135	6	81d908594d2983ba7e7c1ec25afdde4315d9690e
ToppCell	COVID-19-kidney-CD-PC\|kidney / Disease (COVID-19 only), tissue and cell type	ANK3 ROR2 KCNQ1 KCNIP4 TRPV4 MAP3K21	2.74e-05	193	135	6	738689d009e4b118d7ce3171a207294b95cbe78b
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIVEP2 DSCAM RYR2 LDB2 MRTFB KCNIP4	2.90e-05	195	135	6	2e1df01bf6e4e98e6cd9fb50926e34c5077b8666
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C4A RORC C4B WDR90 GMPPA	3.67e-05	123	135	5	a45d6907c041ad3f3218cd46dccfc25d4bd961cb
Disease	third ventricle volume measurement	ANK3 LDB2 LDB1	3.10e-05	15	123	3	EFO_0010335
Disease	Mammary Neoplasms, Experimental	STAT3 STAT5A GH1 PKM RPL3 CDK4	4.88e-05	155	123	6	C0024668
Disease	Joubert syndrome 1	INPP5E ARL13B CSPP1	8.90e-05	21	123	3	C4551568
Disease	Leukemia, T-Cell	STAT3 NOTCH1	1.71e-04	5	123	2	C0023492
Disease	glucose tolerance test	ABCC8 KCNQ1 MAP4K2	1.92e-04	27	123	3	EFO_0004307
Disease	Familial aplasia of the vermis	INPP5E ARL13B CSPP1	2.64e-04	30	123	3	C0431399
Disease	creatinine measurement	P4HA2 DSCAM LAMA5 CASP9 GOLPH3 ADGRV1 STAT3 PHC2 KCNQ1 NCOA7 TRPV4 DLEC1 MRTFA	2.70e-04	995	123	13	EFO_0004518
Disease	Animal Mammary Neoplasms	STAT3 STAT5A PKM RPL3 CDK4	3.30e-04	142	123	5	C0024667
Disease	Mammary Carcinoma, Animal	STAT3 STAT5A PKM RPL3 CDK4	3.30e-04	142	123	5	C1257925
Disease	serum IgG glycosylation measurement	HIVEP2 DSCAM ETV6 RYR2 SBF1 SLIT1 KCNIP4 RPL3 SHISA6	3.56e-04	523	123	9	EFO_0005193
Disease	DIABETES MELLITUS, PERMANENT NEONATAL	STAT3 ABCC8	3.57e-04	7	123	2	C1833104
Disease	QT interval	DGKD SLC4A3 STAT3 LDB2 DOCK5 ABCC8 KCNQ1 NCOA7 NUP160	4.13e-04	534	123	9	EFO_0004682
Disease	menstrual cycle measurement	DOCK5 NOTCH1	4.75e-04	8	123	2	EFO_0007786
Disease	Carcinomatosis	STAT3 STAT5A PKM RPL3 CDK4	6.19e-04	163	123	5	C0205699
Disease	Carcinoma, Spindle-Cell	STAT3 STAT5A PKM RPL3 CDK4	6.19e-04	163	123	5	C0205697
Disease	Undifferentiated carcinoma	STAT3 STAT5A PKM RPL3 CDK4	6.19e-04	163	123	5	C0205698
Disease	Anaplastic carcinoma	STAT3 STAT5A PKM RPL3 CDK4	6.19e-04	163	123	5	C0205696
Disease	JT interval	DGKD SLC4A3 STAT3 ABCC8 KCNQ1 NCOA7	6.21e-04	248	123	6	EFO_0007885
Disease	Carcinoma	STAT3 STAT5A PKM RPL3 CDK4	6.36e-04	164	123	5	C0007097
Disease	pulse pressure measurement	P4HA2 DSCAM TTI2 LAMA5 SLC22A17 STAT3 LDB2 PHC2 FBXO38 LDB1 SLIT1 FGD5 DLEC1 NUP160 MAP4K2	6.95e-04	1392	123	15	EFO_0005763
Disease	sexual dimorphism measurement	P4HA2 EPPK1 HIVEP2 INPP5E RGPD1 ETV6 RAD54L2 GH1 PNPLA1 CEP250 SLIT1 CDK5RAP1 KCNQ1	7.31e-04	1106	123	13	EFO_0021796
Disease	response to radiation, Abnormality of the urinary system	STOX2 ABCC8	7.59e-04	10	123	2	GO_0009314, HP_0000079
Disease	type 2 diabetes mellitus (is_implicated_in)	CASP9 RRAD STAT3 ABCC8 CDK4	7.68e-04	171	123	5	DOID:9352 (is_implicated_in)
Disease	body weight	HIVEP2 BCL2L11 ROR2 RGPD1 ETV6 ADGRV1 LDB2 PHC2 GH1 ABCC8 SLIT1 KCNQ1 RPL3 NUP160	7.93e-04	1261	123	14	EFO_0004338
Disease	Long QT Syndrome	RYR2 KCNQ1	9.25e-04	11	123	2	C0023976
Disease	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	ETV6 STAT3	1.11e-03	12	123	2	C0023485
Disease	salicylurate measurement	RYR2 CHTF18	1.30e-03	13	123	2	EFO_0010532
Disease	Squamous cell carcinoma of the head and neck	STAT3 NOTCH1 CDK4	1.35e-03	52	123	3	C1168401
Disease	ankylosing spondylitis, psoriasis, ulcerative colitis, Crohn's disease, sclerosing cholangitis	TNIP1 STAT3 PUS10 RORC RPL3 NOTCH1	1.52e-03	295	123	6	EFO_0000384, EFO_0000676, EFO_0000729, EFO_0003898, EFO_0004268
Disease	body surface area	P4HA2 ROR2 RGPD1 ETV6 DOCK5 SLIT1 NCOA7 DLEC1 RPL3	1.53e-03	643	123	9	EFO_0022196
Disease	Psoriasis	TNIP1 STAT3 CARD14	1.76e-03	57	123	3	C0033860
Disease	Pustulosis of Palms and Soles	TNIP1 STAT3 CARD14	1.76e-03	57	123	3	C0030246
Disease	Malignant neoplasm of breast	KLK15 ERCC6 WNT10B TNIP1 RRAD TESK1 STAT3 STAT5A PHKB FGD5 DLEC1 NOTCH1	1.80e-03	1074	123	12	C0006142
Disease	myopia (is_implicated_in)	P4HA2 CPSF1	1.99e-03	16	123	2	DOID:11830 (is_implicated_in)
Disease	central nervous system disease (implicated_via_orthology)	SMARCA5 TAOK1	1.99e-03	16	123	2	DOID:331 (implicated_via_orthology)
Disease	Malignant Neoplasms	SF3B1 ARHGAP45 NOTCH1 CDK4	2.06e-03	128	123	4	C0006826
Disease	heart disease (biomarker_via_orthology)	CASP9 STAT3	2.25e-03	17	123	2	DOID:114 (biomarker_via_orthology)
Disease	Intellectual Disability	HIVEP2 INPP5E TTI2 PEX6 SPECC1L ARL13B TAOK1	2.75e-03	447	123	7	C3714756
Disease	blood metabolite measurement	GMPS SARDH	2.81e-03	19	123	2	EFO_0005664
Disease	ulcerative colitis	STAT3 PUS10 SLIT1 RORC RPL3 NOTCH1	2.86e-03	335	123	6	EFO_0000729
Disease	renal cell carcinoma (is_implicated_in)	STAT3 C4A C4B	3.03e-03	69	123	3	DOID:4450 (is_implicated_in)
Disease	Familial aplasia of the vermis	INPP5E ARL13B	3.12e-03	20	123	2	cv:C0431399
Disease	Lupus Erythematosus, Systemic	TNIP1 C4A C4B	3.29e-03	71	123	3	C0024141
Disease	Noise-induced hearing loss	KCNQ1 TAOK1	3.77e-03	22	123	2	C0018781
Disease	Sarcosine measurement	PEX6 SARDH	4.12e-03	23	123	2	EFO_0021668
Disease	sensory peripheral neuropathy, remission	PRR18 DLEC1	4.12e-03	23	123	2	EFO_0009785, MONDO_0002321

Protein segments in the cluster

Peptide	Gene	Start	Entry
APRNHEQRLEHIMRR	CHTF18	891	Q8WVB6
RRPHEVFVELNELML	SLC4A3	316	P48751
MERELEALAARLARP	C2orf72	1	A6NCS6
REFHLHLRLPMSVRR	C4B	831	P0C0L5
HLRLPMSVRRFEQLE	C4B	836	P0C0L5
LGEHVVRMLLQREPR	HSD3B7	21	Q9H2F3
MRRLHLIVTRQPNRA	ADGRV1	5386	Q8WXG9
MPVLSARRRELADHA	CLK3	1	P49761
HLRNELRDMRAQLGI	SPECC1L	201	Q69YQ0
EDHPRMVILRLLRYI	BCL2L11	176	O43521
LRMKRNHRVEPLNID	ARL13B	351	Q3SXY8
PEMVHLLVSRRCELN	ANKRD36B	66	Q8N2N9
PSHMRRNIRKLLRED	RAD54L2	106	Q9Y4B4
AKMRARNHLILPERL	ERCC6	1391	Q03468
DIPRRNLLDHLTRMR	INTS6	546	Q9UL03
RIFQEALRLAHMEPV	HDHD3	171	Q9BSH5
RLEALMRWVRHDPQA	KLHL30	196	Q0D2K2
MALLRDVSLQDPRDR	MAP4K2	1	Q12851
HRRSMPVDERDLQAA	RRAD	36	P55042
LRMEEDSIRLPAHLR	ETV6	41	P41212
FALPRHSAVMERLRR	MAML1	11	Q92585
RFLQILRMLHVDRQG	KCNQ1	231	P51787
PHVRLLRQRMDRLDN	MDN1	3291	Q9NU22
NRDITDHMDRLPRDI	NOTCH1	2086	P46531
FMQPLTLRRLEHEKR	ARHGAP45	366	Q92619
IRQHRELIPRSILAM	LDB1	201	Q86U70
VPALLQHDQLIREMR	INPP5E	501	Q9NRR6
EARLQVALAEMPLHR	GTPBP6	216	O43824
TDPRVAERLMQQLHR	MUC20	676	Q8N307
RELVPRSILAMHAQD	LDB2	166	O43679
LNPRAFRMLHVDRRT	CPSF1	1376	Q10570
PAMANHLRLRQVLSR	PNMA6F	376	A0A0J9YX94
RSHRNDIMLLRLVQP	KLK15	101	Q9H2R5
RRRVDHFLCEMPALI	OR2W5P	171	A6NFC9
RVMAVLRHLLLNEDP	PEX6	546	Q13608
AAAHMLRALQPRRTR	C19orf85	26	A0A1B0GUS0
DIFDMARHRLQAPVR	CSPP1	981	Q1MSJ5
KNRRPRHLFLMNDVL	FGD5	1126	Q6ZNL6
LEMATVRHRPEALEL	KCNIP4	61	Q6PIL6
RSRPDRSELVRMHIL	MRTFB	91	Q9ULH7
RDLAPRMLETAHRFA	PNPLA1	36	Q8N8W4
IRAELMNRVRDLRHP	PRAMEF15	436	P0DUQ1
MNRVRDLRHPKRILF	PRAMEF15	441	P0DUQ1
PLEAVRMQHLIAREA	PKM	371	P14618
RHKQPTLLMVRASRR	C6orf223	31	Q8N319
LPGRQELLVAVHMLR	EPHA10	666	Q5JZY3
ERQPGTEMLRADLRH	LAMA5	1666	O15230
RRLHDLVLPLVMGVQ	PELP1	546	Q8IZL8
PSAIEMQLRRVLHDI	ITPRID2	906	P28290
LDARVQAPRVVHMLA	GPR84	341	Q9NQS5
VARMRADENHPQRVL	SBF1	451	O95248
DDPVVARVNRRMQHI	P4HA2	391	O15460
ARNLEHLEMVRVPFL	FBXO38	261	Q6PIJ6
RLHDELFRRILRSPM	ABCC5	946	O15440
RRPLAVRARVIHFME	PUS10	451	Q3MIT2
NRSPRHMIEEIVLVD	GALNT1	141	Q10472
MLEAHRRQRHPFLLL	GMPPA	126	Q96IJ6
RAMERTVENIVLPRH	FBH1	1021	Q8NFZ0
LARLIPRMCHNVNRV	GMPS	546	P49915
REKQRLVRMHAICPR	CARD14	426	Q9BXL6
TAVHIQLIMERLLRR	DOCK5	921	Q9H7D0
RRLEAFEHPNVVRLM	CDK4	61	P11802
LPADLEALQREIRMA	GJC1	331	P36383
SRELFRPHMIEDIQR	CASP9	31	P55211
RSMREHPALRSLRLL	COMTD1	61	Q86VU5
RSVLEHLPMAVQERE	CEP250	1486	Q9BV73
VNDPHRMDRRLLALI	GOLPH3	226	Q9H4A6
AVSHIPVRVADERRM	ANK3	2956	Q12955
TRGPEAELVVMRRLH	MAST3	1241	O60307
LAEMDRQLRRLADTP	DGKD	1076	Q16760
PIRVHNLQMKLRRDD	CEP57L1	441	Q8IYX8
IPRCQERLLRVSQHM	CEP295	1236	Q9C0D2
ERLLRVSQHMLPLQD	CEP295	1241	Q9C0D2
WMNHLRVPQRELDRL	DLEC1	301	Q9Y238
EDPELVRAMFVLLHR	RYR2	2076	Q92736
LRPMLKVSLLNERHR	PRR18	231	Q8N4B5
REFHLHLRLPMSVRR	C4A	831	P0C0L4
HLRLPMSVRRFEQLE	C4A	836	P0C0L4
MHGRPLFLVLIREDN	PHKB	611	Q93100
VRPDDVHMNIRLVEL	RGPD1	151	P0DJD0
MATLRRLREAPRHLL	RPP40	1	O75818
LRMHIDIPRAQLLIE	DSCAM	1656	O60469
RIRPMNRRETDLHTK	KIF13B	11	Q9NQT8
HQRELMLANELRADP	RHOXF1	161	Q8NHV9
RNAILSRAPHMIRDR	RAPGEF4	211	Q8WZA2
GRLDQLLRHVMNPLE	PRAME	311	P78395
PRRTLQEHRLDSNLM	TMEM132E	281	Q6IEE7
QEHRLDSNLMIRLPD	TMEM132E	286	Q6IEE7
QALLLHQRARMERLA	TAB3	516	Q8N5C8
LRILAERNRPHGQML	SLC22A17	256	Q8WUG5
EARLFAMLRHPNIIE	MAP3K21	171	Q5TCX8
MHIEQLARRLPARVQ	NCOA7	786	Q8NI08
RVIAHTQMRLLPLRQ	RPL3	161	P39023
PDHSMRIRIIEFLQA	SAMD3	166	Q8N6K7
QGLIRHFRPELEERM	NDUFV1	436	P49821
VRLHMLLQTAVPARR	NBEAL2	1601	Q6ZNJ1
TQERMSIPEALRRHI	EPPK1	1581	P58107
IRAELMKRVRDLRHP	PRAMEF25	436	A6NGN4
PREMNIHRALADILR	SHISA6	206	Q6ZSJ9
RMLLGRHNLEQDLVR	TAOK1	621	Q7L7X3
HRGLRMLFPEAQRLE	TFB1M	261	Q8WVM0
HLAMDSQRRPLLLQV	TELO2	321	Q9Y4R8
IRAELMNRVRDLRHP	PRAMEF27	436	A3QJZ7
PLREEFRHEAMLRAR	ROR2	516	Q01974
RNPIHAIGLLIREMD	NUP160	666	Q12769
RSRPERSELVRMHIL	MRTFA	31	Q969V6
QHLDHVRRRLMFEPR	L3HYPDH	56	Q96EM0
RNMRRDPLHEELLGQ	SARDH	481	Q9UL12
RNLQREIEIMRGLRH	STK36	46	Q9NRP7
ARHVEELLRRPMDSL	STAT5A	761	P42229
IPTERNLLALIHRMI	U2SURP	421	O15042
LHRSLLNRIILAPMR	ABCC8	1096	Q09428
HLLDQVSRVDPEMRI	CDK5RAP1	356	Q96SZ6
ILLPLEERVTHFRDM	TCERG1L	446	Q5VWI1
PREDGNLMLHLQRLE	TNIP1	151	Q15025
IRAELMNRVRDLRHP	PRAMEF4	436	O60810
MNRVRDLRHPKRILF	PRAMEF4	441	O60810
RRRQGQRDLELPDMH	PHC2	761	Q8IXK0
DCQRMVVRHARRLLP	WDR90	586	Q96KV7
MDRAPQRQHRASREL	RORC	1	P51449
EMLLAPDIRHERNVI	NUFIP1	456	Q9UHK0
ILTHMEPEHRLLLRR	TTI2	346	Q6NXR4
PLLEDALMDRDLVHR	SF3B1	1171	O75533
RRINPDLTVENVMRH	STOX2	316	Q9P2F5
HRPMLEERIVELFRN	STAT3	301	P40763
IRAELMNRVRDLRHP	PRAMEF9	436	P0DUQ2
MNRVRDLRHPKRILF	PRAMEF9	441	P0DUQ2
ADKLHRARRMDLAPQ	TTC41P	1156	Q6P2S7
LEPFVMREVRARLAA	THUMPD2	26	Q9BTF0
LAQRVPLRENREMSH	TROAP	281	Q12815
PLSRLFDNAMLRAHR	GH1	31	P01241
NTLREVQLMNRLRHP	TESK1	96	Q15569
LRREQLMHQAVEDLP	VILL	796	O15195
ELRNKREFRRNLPMH	ZNFX1	696	Q9P2E3
RLDAAPHMRIRLSNI	ZBED5	661	Q49AG3
LLQAMEPVHVARNLR	PSMD5	71	Q16401
SREAPRDIQARMRIH	WNT10B	216	O00744
APHLAREFMIKTRRR	EFTUD2	926	Q15029
VERLHMVLRPFLLRR	SMARCA5	381	O60264
RHLSPRKEAALRREM	HIVEP2	2086	P31629
LERLRLNRNQLHMLP	SLIT1	111	O75093
RMLQPDVSQRLHIDE	TSSK2	251	Q96PF2
RHEMLAVEPINELLR	TRPV4	446	Q9HBA0
INRRLAMEHRACPSR	HECTD3	476	Q5T447