Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionIgM binding

LILRA2 LILRA4

1.53e-0411342GO:0001791
GeneOntologyMolecularFunctioninhibitory MHC class I receptor activity

LILRA2 LILRA4

1.84e-0412342GO:0032396
GeneOntologyMolecularFunctionMHC class I receptor activity

LILRA2 LILRA4

4.23e-0418342GO:0032393
GeneOntologyBiologicalProcessembryonic retina morphogenesis in camera-type eye

HIPK2 HIPK1

3.71e-056332GO:0060059
GeneOntologyBiologicalProcesslens induction in camera-type eye

HIPK2 HIPK1

5.19e-057332GO:0060235
GeneOntologyBiologicalProcessiris morphogenesis

HIPK2 HIPK1

1.35e-0411332GO:0061072
GeneOntologyBiologicalProcessnegative regulation of lipopolysaccharide-mediated signaling pathway

LILRA2 CARD8

2.23e-0414332GO:0031665
GeneOntologyCellularComponentFc-epsilon receptor I complex

LILRA2 LILRA4

9.73e-059352GO:0032998
GeneOntologyCellularComponentFc receptor complex

LILRA2 LILRA4

1.78e-0412352GO:0032997
DomainA1B_glyco/leuk_Ig-like_rcpt

LILRA2 LILRA4

5.09e-056352IPR016332
DomainSer/Thr_kinase_AS

HIPK2 HIPK1 CSNK1G3 CLK4

4.31e-03357354IPR008271
DomainS_TKc

HIPK2 HIPK1 CSNK1G3 CLK4

4.39e-03359354SM00220
DomainQuinoprotein_ADH-like_supfam

WDR90 EML6

4.43e-0353352IPR011047
DomainPROTEIN_KINASE_ST

HIPK2 HIPK1 CSNK1G3 CLK4

4.52e-03362354PS00108
DomainProtein_kinase_ATP_BS

HIPK2 HIPK1 CSNK1G3 CLK4

5.32e-03379354IPR017441
DomainPkinase

HIPK2 HIPK1 CSNK1G3 CLK4

5.42e-03381354PF00069
DomainIg_2

LILRA2 LILRA4

8.25e-0373352PF13895
DomainPROTEIN_KINASE_ATP

HIPK2 HIPK1 CSNK1G3 CLK4

1.03e-02459354PS00107
PathwayWP_MIR222_IN_EXERCISEINDUCED_CARDIAC_GROWTH

HIPK2 HIPK1

4.07e-055292MM15988
PathwayREACTOME_PHYSIOLOGICAL_FACTORS

HIPK2 HIPK1

3.66e-0414292M27459
PathwayREACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION

HIPK2 HIPK1

4.22e-0415292M603
Pubmed

Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation.

HIPK2 HIPK1

9.84e-07235220231426
Pubmed

Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7.

LILRA2 LILRA4

2.95e-06335212529506
Pubmed

Update on the Regulation of HIPK1, HIPK2 and HIPK3 Protein Kinases by microRNAs.

HIPK2 HIPK1

2.95e-06335229793420
Pubmed

Stabilization of HIPK2 by escape from proteasomal degradation mediated by the E3 ubiquitin ligase Siah1.

HIPK2 HIPK1

5.90e-06435219250734
Pubmed

Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).

HIPK2 HIPK1

5.90e-06435225630557
Pubmed

Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.

HIPK2 HIPK1

5.90e-06435234785661
Pubmed

Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.

HIPK2 HIPK1

1.47e-05635212529400
Pubmed

Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis.

HIPK2 HIPK1

1.47e-05635220579985
Pubmed

Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation.

HIPK2 HIPK1

1.47e-05635216917507
Pubmed

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors.

HIPK2 HIPK1

1.47e-0563529748262
Pubmed

Role of the C-terminal binding protein PXDLS motif binding cleft in protein interactions and transcriptional repression.

HIPK2 HIPK1

3.53e-05935216940173
Pubmed

Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals.

HIPK2 HIPK1

6.45e-051235216537918
Pubmed

A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells.

LILRA2 LILRA4

1.02e-04153529144225
Pubmed

Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism.

HIPK2 HIPK1

3.93e-042935223565059
Pubmed

Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.

RPL29 MATR3 NAF1 YLPM1

8.24e-0442135434650049
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZNF480 LILRA2 ZNF227 CARD8 LILRA4 ZNF347

2.58e-041192356chr19q13
Cytoband19q13.4

LILRA2 LILRA4

1.68e-037935219q13.4
CytobandEnsembl 112 genes in cytogenetic band chr2p16

PSME4 EML6

3.87e-03121352chr2p16
GeneFamilyCD molecules|Activating leukocyte immunoglobulin like receptors

LILRA2 LILRA4

1.92e-0562121181
ToppCellSmart-seq2-spleen_(Smart-seq2)-lymphocytic-innate_lymphocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HIPK2 GSAP HIPK1 PARP8

1.34e-05186354fc0b488c201a32d829047b58460297df2818b45d
ToppCellSmart-seq2-spleen_(Smart-seq2)-lymphocytic-innate_lymphocytic-mature_NK_T_cell|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HIPK2 GSAP HIPK1 PARP8

1.37e-051873546981b856187a2e689260ecb7d0a1193a374ee9b9
ToppCellLV-08._Macrophage|World / Chamber and Cluster_Paper

NEURL2 CD163L1 PARP8 TRPM2

1.49e-05191354e7a0bc46ba9ba772636a583f3387748418e18832
ToppCellRV-08._Macrophage|World / Chamber and Cluster_Paper

NEURL2 CD163L1 PARP8 TRPM2

1.52e-05192354a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCellLV-08._Macrophage|LV / Chamber and Cluster_Paper

NEURL2 CD163L1 PARP8 TRPM2

1.52e-051923547be12d580aaf2f2f1562203fcad3a44639b8c5a6
ToppCellRV-08._Macrophage|RV / Chamber and Cluster_Paper

NEURL2 CD163L1 PARP8 TRPM2

1.55e-0519335412bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GSAP NEURL2 CD163L1 TRPM2

1.58e-0519435445708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCellLA-08._Macrophage|World / Chamber and Cluster_Paper

NEURL2 CD163L1 PARP8 TRPM2

1.58e-05194354c1805572bcc11b1cd29083329d7b5911489fb758
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GSAP NEURL2 CD163L1 TRPM2

1.61e-05195354247803cf58c6d9c561a52aa34e581188ddad197e
ToppCellCOVID-19-Myeloid-Monocyte-derived_macrophages|COVID-19 / group, cell type (main and fine annotations)

GSAP NEURL2 CD163L1 TRPM2

1.61e-05195354c172c5599379c29123340621a36bfb1fc90c2115
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW13-Mesenchymal-Mesoderm|GW13 / Sample Type, Dataset, Time_group, and Cell type.

WDR90 MYO15A PARP8 NAF1

1.78e-052003540f4b8b0868bda406fe6bf01d1b722510fdfd0168
DrugPargyline hydrochloride [306-07-0]; Down 200; 20.4uM; HL60; HG-U133A

HIPK2 PSME4 CLK4 MATR3 YLPM1

1.04e-051913551418_DN
DrugNizatidine [76963-41-2]; Down 200; 12uM; HL60; HT_HG-U133A

HIPK2 ZNF480 LILRA2 SGSM3 MYO15A

1.15e-051953553047_DN
Diseasepuberty onset measurement

BIRC6 JHY TRPM2

3.69e-04125333EFO_0005677
DiseaseX-12063 measurement

AGBL1 MATR3 TRPM2

1.17e-03186333EFO_0021283
DiseaseGastrointestinal Stromal Sarcoma

HIPK2 HIPK1

1.27e-0347332C3179349
DiseaseGastrointestinal Stromal Tumors

HIPK2 HIPK1

1.44e-0350332C0238198

Protein segments in the cluster

PeptideGeneStartEntry
GQHLHAARWHQKDSG

ARSD

461

P51689
HHGDAAQHTRTWKLQ

BIRC6

1066

Q9NR09
QSPTHFNDNQWHHVR

CNTNAP4

866

Q9C0A0
HRGWGNHDCSHNEDV

CD163L1

236

Q9NR16
NHGHYSNHDLGWQNL

DKK2

151

Q9UBU2
LNRVHSAVWNGNHGA

CECR2

786

Q9BXF3
LLGLHQDWHSHDTAN

AGBL1

191

Q96MI9
EHPQRLNSHSHARGW

LILRA2

161

Q8N149
FHGSHIENWHSILRN

PARP8

696

Q8N3A8
RLSWTLNSHQHNHGK

LILRA4

161

P59901
QQLADWRNTHAHGSH

HIPK2

746

Q9H2X6
HSNKEWSQHINGASH

MATR3

301

P43243
REQNHHTWDQGANNR

JHY

101

Q6NUN7
LANQVWHNHNAHNAE

MYO15A

2131

Q9UKN7
WHNHNAHNAERGWLL

MYO15A

2136

Q9UKN7
SGQQLADWRNAHSHG

HIPK1

786

Q86Z02
QGEQTANGAWDRHSH

PCNX3

691

Q9H6A9
HRAAWDSQQANPHHL

CSNK1G3

366

Q9Y6M4
NLGHTWVFAITRHHN

NEURL2

106

Q9BR09
HNLHSWVLHFNSRGS

GSAP

656

A4D1B5
FGSWSQHLALDLQHH

CARD8

211

Q9Y2G2
GQWSQQAIIHHGLQH

FAM172BP

121

A6NC97
GHSAHVTNVRWLHND

EML6

1236

Q6ZMW3
HHNQLDWDEHSSAGR

CLK4

411

Q9HAZ1
NHTTHNQSRKWHRNG

RPL29

6

P47914
HHVQHILSQGRCNWF

RSPH4A

546

Q5TD94
RWQAHLEFTHNHDVG

SGSM3

76

Q96HU1
NAWLQNHAHWGRHIV

SLC36A2

136

Q495M3
LHSGAQQHWSGHSAE

WDR90

1146

Q96KV7
DAALWHRSNHSNADN

RHBG

41

Q9H310
SRSQDHFGHENWDHQ

TRPM2

441

O94759
LSNFRRTHHDNWQEH

PSME4

1806

Q14997
AAAHWQQHQQHRVGF

YLPM1

386

P49750
TQNSHLTNHWRIHTG

ZNF347

411

Q96SE7
IQNSHLAQHWRIHTG

ZNF480

381

Q8WV37
SWRSNLHAHQRVHSG

ZNF227

586

Q86WZ6
VHQNWNAHSSASEHA

NAF1

351

Q96HR8