Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	NPBWR1 NPBWR2 TAS2R16 OR52A4P SLC39A9 AVPR1A GPR68 OR52H1 OR10W1 ADGRE4P ADGRA1 ADGRF4 GPRC6A ADGRF1 GPR132 GPR148 OR52J3	9.36e-10	884	62	17	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	NPBWR1 NPBWR2 TAS2R16 OR52A4P SLC39A9 AVPR1A GPR68 OR52H1 OR10W1 ADGRE4P ADGRA1 ADGRF4 GPRC6A ADGRF1 GPR132 GPR148 OR52J3	4.82e-07	1353	62	17	GO:0004888
GeneOntologyMolecularFunction	transporter activity	SLC6A6 SLCO5A1 ANO2 AQP10 RHBDF2 SLC2A8 SLC39A9 SLC15A4 SLC2A6 SLC49A4 SLC49A3 SLC25A47 DISP1	1.35e-04	1289	62	13	GO:0005215
GeneOntologyMolecularFunction	G protein-coupled opioid receptor activity	NPBWR1 NPBWR2	1.97e-04	7	62	2	GO:0004985
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC6A6 SLCO5A1 ANO2 AQP10 SLC2A8 SLC39A9 SLC15A4 SLC2A6 SLC49A4 SLC49A3 SLC25A47 DISP1	2.37e-04	1180	62	12	GO:0022857
GeneOntologyMolecularFunction	dehydroascorbic acid transmembrane transporter activity	SLC2A8 SLC2A6	2.62e-04	8	62	2	GO:0033300
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC6A6 SLCO5A1 SLC2A8 SLC15A4 SLC2A6 SLC25A47	2.93e-04	293	62	6	GO:0008514
GeneOntologyMolecularFunction	carbohydrate transmembrane transporter activity	AQP10 SLC2A8 SLC2A6	3.00e-04	42	62	3	GO:0015144
GeneOntologyMolecularFunction	amide transmembrane transporter activity	AQP10 SLC15A4 SLC25A47	3.00e-04	42	62	3	GO:0042887
GeneOntologyMolecularFunction	fructose transmembrane transporter activity	SLC2A8 SLC2A6	3.37e-04	9	62	2	GO:0005353
GeneOntologyMolecularFunction	peptide transmembrane transporter activity	SLC15A4 DISP1	3.37e-04	9	62	2	GO:1904680
GeneOntologyMolecularFunction	D-glucose transmembrane transporter activity	SLC2A8 SLC2A6	2.72e-03	25	62	2	GO:0055056
GeneOntologyMolecularFunction	hexose transmembrane transporter activity	SLC2A8 SLC2A6	2.72e-03	25	62	2	GO:0015149
GeneOntologyMolecularFunction	monosaccharide transmembrane transporter activity	SLC2A8 SLC2A6	3.17e-03	27	62	2	GO:0015145
GeneOntologyMolecularFunction	sugar transmembrane transporter activity	SLC2A8 SLC2A6	3.65e-03	29	62	2	GO:0051119
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	NPBWR1 NPBWR2 TAS2R16 OR52A4P SLC39A9 AVPR1A GPR68 OR52H1 OR10W1 ADGRE4P ADGRA1 ADGRF4 GPRC6A ADGRF1 GPR132 GPR148 OR52J3	4.71e-07	1395	62	17	GO:0007186
GeneOntologyBiologicalProcess	meiotic chromosome movement towards spindle pole	ACTR3 ACTR2	2.66e-05	3	62	2	GO:0016344
GeneOntologyCellularComponent	podosome core	ACTR3 ACTR2	2.43e-05	3	60	2	GO:0061825
GeneOntologyCellularComponent	Arp2/3 protein complex	ACTR3 ACTR2	3.59e-04	10	60	2	GO:0005885
MousePheno	abnormal basisphenoid bone morphology	ADAMTS3 APAF1 MORC2 DISP1	3.89e-05	57	47	4	MP:0000106
MousePheno	absent occipital bone	MORC2 DISP1	6.61e-05	4	47	2	MP:0004440
MousePheno	absent segment of anterior cerebral artery	ADAMTS3 MORC2	6.61e-05	4	47	2	MP:0013823
MousePheno	abnormal anterior cerebral artery morphology	ADAMTS3 MORC2	6.61e-05	4	47	2	MP:0013822
MousePheno	persistent dorsal ophthalmic artery	ADAMTS3 MORC2	1.10e-04	5	47	2	MP:0013992
MousePheno	absent pituitary gland	MORC2 DISP1	1.65e-04	6	47	2	MP:0005315
MousePheno	abnormal ophthalmic artery morphology	ADAMTS3 MORC2	1.65e-04	6	47	2	MP:0020489
Domain	Arp3_met	ACTR3C ACTR3B ACTR3	3.31e-08	3	61	3	IPR015623
Domain	ACTINS_ACT_LIKE	ACTR3C ACTR3B ACTR3 ACTR2	3.85e-07	19	61	4	PS01132
Domain	Actin	ACTR3C ACTR3B ACTR3 ACTR2	3.03e-06	31	61	4	IPR004000
Domain	Actin	ACTR3C ACTR3B ACTR3 ACTR2	3.03e-06	31	61	4	PF00022
Domain	ACTIN	ACTR3C ACTR3B ACTR3 ACTR2	3.03e-06	31	61	4	SM00268
Domain	MFS_dom	SLCO5A1 SLC2A8 SLC15A4 SLC2A6 SLC49A4 SLC49A3	4.90e-06	134	61	6	IPR020846
Domain	Neuropept_B/W_rcpt	NPBWR1 NPBWR2	1.05e-05	2	61	2	IPR009150
Domain	G_PROTEIN_RECEP_F2_2	ADGRE4P ADGRA1 ADGRF4 ADGRF1	2.12e-05	50	61	4	PS00650
Domain	7tm_2	ADGRE4P ADGRA1 ADGRF4 ADGRF1	2.12e-05	50	61	4	PF00002
Domain	Actin/actin-like_CS	ACTR3B ACTR3 ACTR2	2.61e-05	18	61	3	IPR020902
Domain	MFS	SLCO5A1 SLC2A8 SLC2A6 SLC49A4 SLC49A3	2.71e-05	108	61	5	PS50850
Domain	GPCR_2_secretin-like	ADGRE4P ADGRA1 ADGRF4 ADGRF1	4.38e-05	60	61	4	IPR000832
Domain	G_PROTEIN_RECEP_F2_4	ADGRE4P ADGRA1 ADGRF4 ADGRF1	4.68e-05	61	61	4	PS50261
Domain	GPCR_Rhodpsn_7TM	NPBWR1 NPBWR2 OR52A4P AVPR1A GPR68 OR52H1 OR10W1 GPR132 GPR148 OR52J3	5.70e-05	670	61	10	IPR017452
Domain	7tm_1	NPBWR1 NPBWR2 OR52A4P AVPR1A GPR68 OR52H1 OR10W1 GPR132 GPR148 OR52J3	6.21e-05	677	61	10	PF00001
Domain	GPCR_2_Ig-hepta-like_rcpt	ADGRF4 ADGRF1	6.27e-05	4	61	2	IPR008078
Domain	G_PROTEIN_RECEP_F1_1	NPBWR1 NPBWR2 OR52A4P AVPR1A GPR68 OR52H1 OR10W1 GPR132 GPR148 OR52J3	6.85e-05	685	61	10	PS00237
Domain	G_PROTEIN_RECEP_F1_2	NPBWR1 NPBWR2 OR52A4P AVPR1A GPR68 OR52H1 OR10W1 GPR132 GPR148 OR52J3	7.37e-05	691	61	10	PS50262
Domain	GPCR_Rhodpsn	NPBWR1 NPBWR2 OR52A4P AVPR1A GPR68 OR52H1 OR10W1 GPR132 GPR148 OR52J3	7.46e-05	692	61	10	IPR000276
Domain	GPS	ADGRE4P ADGRF4 ADGRF1	2.01e-04	35	61	3	PF01825
Domain	GPS	ADGRE4P ADGRF4 ADGRF1	2.19e-04	36	61	3	PS50221
Domain	GPS	ADGRE4P ADGRF4 ADGRF1	2.38e-04	37	61	3	IPR000203
Domain	Sugar/inositol_transpt	SLC2A8 SLC2A6	9.31e-04	14	61	2	IPR003663
Domain	GPCR_2-like	ADGRA1 ADGRF4 ADGRF1	9.94e-04	60	61	3	IPR017981
Domain	SUGAR_TRANSPORT_2	SLC2A8 SLC2A6	1.38e-03	17	61	2	PS00217
Domain	SUGAR_TRANSPORT_1	SLC2A8 SLC2A6	2.77e-03	24	61	2	PS00216
Domain	Sugar_transporter_CS	SLC2A8 SLC2A6	4.89e-03	32	61	2	IPR005829
Domain	GPS	ADGRE4P ADGRF1	5.50e-03	34	61	2	SM00303
Domain	Sugar_tr	SLC2A8 SLC2A6	6.15e-03	36	61	2	PF00083
Domain	MFS_sugar_transport-like	SLC2A8 SLC2A6	6.15e-03	36	61	2	IPR005828
Domain	G_PROTEIN_RECEP_F2_1	ADGRF4 ADGRF1	7.56e-03	40	61	2	PS00649
Domain	G_PROTEIN_RECEP_F2_3	ADGRF4 ADGRF1	7.56e-03	40	61	2	PS50227
Domain	GPCR_2_extracellular_dom	ADGRF4 ADGRF1	7.56e-03	40	61	2	IPR001879
Pathway	WP_GPCRS_NONODORANT	NPBWR1 TAS2R16 AVPR1A GPR68 ADGRE4P GPRC6A GPR132	1.42e-05	266	43	7	MM15843
Pathway	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	MYLK ACTR3 ACTR2	1.62e-04	35	43	3	M16801
Pathway	SIG_CHEMOTAXIS	MYLK ACTR3 ACTR2	3.43e-04	45	43	3	M5193
Pathway	REACTOME_GPCR_LIGAND_BINDING	NPBWR1 NPBWR2 TAS2R16 AVPR1A GPR68 GPRC6A GPR132	4.56e-04	463	43	7	M507
Pathway	KEGG_MEDICUS_PATHOGEN_SHIGELLA_IPAC_TO_ACTIN_SIGNALING_PATHWAY	ACTR3 ACTR2	6.94e-04	13	43	2	M47723
Pathway	KEGG_MEDICUS_PATHOGEN_ESCHERICHIA_MAP_TO_CDC42_SIGNALING_PATHWAY	ACTR3 ACTR2	6.94e-04	13	43	2	M47730
Pathway	KEGG_MEDICUS_PATHOGEN_ESCHERICHIA_EAE_TIR_TCCP_TO_ACTIN_SIGNALING_PATHWAY	ACTR3 ACTR2	8.08e-04	14	43	2	M47729
Pathway	KEGG_MEDICUS_PATHOGEN_ESCHERICHIA_ESPT_TO_RAC_SIGNALING_PATHWAY	ACTR3 ACTR2	8.08e-04	14	43	2	M47726
Pathway	WP_NRF2_PATHWAY	SLC6A6 SLC2A8 SLC39A9 SLC2A6	8.74e-04	141	43	4	M39454
Pathway	WP_PHYSICOCHEMICAL_FEATURES_AND_TOXICITYASSOCIATED_PATHWAYS	MYLK ACTR3 ACTR2	1.06e-03	66	43	3	M39642
Pathway	KEGG_MEDICUS_PATHOGEN_ESCHERICHIA_EAE_TIR_TO_ACTIN_SIGNALING_PATHWAY	ACTR3 ACTR2	1.20e-03	17	43	2	M47728
Pathway	REACTOME_CELLULAR_HEXOSE_TRANSPORT	SLC2A8 SLC2A6	1.50e-03	19	43	2	MM14718
Pathway	KEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPE_TO_RAC_SIGNALING_PATHWAY	ACTR3 ACTR2	1.67e-03	20	43	2	M47737
Pathway	REACTOME_GPCR_LIGAND_BINDING	NPBWR1 TAS2R16 AVPR1A GPR68 GPRC6A GPR132	1.82e-03	430	43	6	MM15160
Pathway	REACTOME_CELLULAR_HEXOSE_TRANSPORT	SLC2A8 SLC2A6	1.84e-03	21	43	2	M27058
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_ACTIN_SIGNALING_PATHWAY	ACTR3 ACTR2	1.84e-03	21	43	2	M47722
Pubmed	The G protein-coupled receptor repertoires of human and mouse.	GPR68 ADGRE4P ADGRA1 ADGRF4 ADGRF1 GPR148	6.94e-09	79	63	6	12679517
Pubmed	The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.	ADGRE4P ADGRA1 ADGRF4 ADGRF1	2.24e-07	29	63	4	15203201
Pubmed	International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.	ADGRE4P ADGRA1 ADGRF4 ADGRF1	3.84e-07	33	63	4	25713288
Pubmed	Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation.	SLC6A6 ACTR3 ACTR2	1.60e-06	13	63	3	31961823
Pubmed	Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis.	ACTR3 ACTR2	3.23e-06	2	63	2	22385962
Pubmed	Arp2/3 complex regulates asymmetric division and cytokinesis in mouse oocytes.	ACTR3 ACTR2	3.23e-06	2	63	2	21494665
Pubmed	The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain.	NPBWR1 NPBWR2	3.23e-06	2	63	2	7590751
Pubmed	Arp2/3 complex regulates adipogenesis by controlling cortical actin remodelling.	ACTR3 ACTR2	3.23e-06	2	63	2	25220164
Pubmed	Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma.	ACTR3C ACTR3B	3.23e-06	2	63	2	11162478
Pubmed	B cells extract antigens at Arp2/3-generated actin foci interspersed with linear filaments.	ACTR3 ACTR2	3.23e-06	2	63	2	31815664
Pubmed	The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches.	ACTR3 ACTR2	3.23e-06	2	63	2	9210376
Pubmed	Actin binding to the central domain of WASP/Scar proteins plays a critical role in the activation of the Arp2/3 complex.	ACTR3 ACTR2	3.23e-06	2	63	2	16403731
Pubmed	Host cell entry by apicomplexa parasites requires actin polymerization in the host cell.	ACTR3 ACTR2	3.23e-06	2	63	2	19286135
Pubmed	Heteromerization of G2A and OGR1 enhances proton sensitivity and proton-induced calcium signals.	GPR68 GPR132	3.23e-06	2	63	2	27049592
Pubmed	Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation.	ACTR3 ACTR2	3.23e-06	2	63	2	31157616
Pubmed	Inhibiting the Arp2/3 complex limits infection of both intracellular mature vaccinia virus and primate lentiviruses.	ACTR3 ACTR2	3.23e-06	2	63	2	15385624
Pubmed	Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts.	ACTR3 ACTR2	3.23e-06	2	63	2	12464680
Pubmed	Loss of Arp2/3 induces an NF-κB-dependent, nonautonomous effect on chemotactic signaling.	ACTR3 ACTR2	3.23e-06	2	63	2	24344184
Pubmed	ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells.	ACTR3B ACTR3	3.23e-06	2	63	2	10806390
Pubmed	Reconstitution of actin-based motility of Listeria and Shigella using pure proteins.	ACTR3 ACTR2	3.23e-06	2	63	2	10524632
Pubmed	Transition State of Arp2/3 Complex Activation by Actin-Bound Dimeric Nucleation-Promoting Factor.	ACTR3 ACTR2	3.23e-06	2	63	2	37549294
Pubmed	A novel role of the actin-nucleating Arp2/3 complex in the regulation of RNA polymerase II-dependent transcription.	ACTR3 ACTR2	3.23e-06	2	63	2	17220302
Pubmed	The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenes.	ACTR3 ACTR2	3.23e-06	2	63	2	10421578
Pubmed	Analysis of the mechanisms of Salmonella-induced actin assembly during invasion of host cells and intracellular replication.	ACTR3 ACTR2	3.23e-06	2	63	2	15469433
Pubmed	Actin nucleator Arp2/3 complex is essential for mouse preimplantation embryo development.	ACTR3 ACTR2	3.23e-06	2	63	2	22951093
Pubmed	Arp2/3 nucleates F-actin coating of fusing insulin granules in pancreatic β cells to control insulin secretion.	ACTR3 ACTR2	3.23e-06	2	63	2	32079655
Pubmed	Arp2/3 complex is required for actin polymerization during platelet shape change.	ACTR3 ACTR2	3.23e-06	2	63	2	12036877
Pubmed	Arp2/3 complex activity in filopodia of spreading cells.	ACTR3 ACTR2	3.23e-06	2	63	2	19068115
Pubmed	Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells.	ACTR3C ACTR3B	3.23e-06	2	63	2	14651955
Pubmed	Arp2/3 complex activity is necessary for mouse ESC differentiation, times formative pluripotency, and enables lineage specification.	ACTR3 ACTR2	3.23e-06	2	63	2	35658973
Pubmed	Proline-rich 11 (PRR11) drives F-actin assembly by recruiting the actin-related protein 2/3 complex in human non-small cell lung carcinoma.	ACTR3 ACTR2	9.68e-06	3	63	2	32169900
Pubmed	Interaction of cortactin and Arp2/3 complex is required for sphingosine-1-phosphate-induced endothelial cell remodeling.	ACTR3 ACTR2	9.68e-06	3	63	2	15242766
Pubmed	Regulation by phosphorylation. Yet another twist in the WASP story.	ACTR3 ACTR2	9.68e-06	3	63	2	12791263
Pubmed	Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.	ACTR3 ACTR2	9.68e-06	3	63	2	26028144
Pubmed	Actin and Arp2/3 localize at the centrosome of interphase cells.	ACTR3 ACTR2	9.68e-06	3	63	2	21108927
Pubmed	Protein Interaction Network of Human Protein Kinase D2 Revealed by Chemical Cross-Linking/Mass Spectrometry.	ACTR3 ACTR2	9.68e-06	3	63	2	27559607
Pubmed	Membrane androgen receptors (OXER1, GPRC6A AND ZIP9) in prostate and breast cancer: A comparative study of their expression.	SLC39A9 GPRC6A	9.68e-06	3	63	2	30707908
Pubmed	Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex.	ACTR3 ACTR2	9.68e-06	3	63	2	17721515
Pubmed	Divide and conquer: the surprising link between motility and the cell cycle (retrospective on DOI 10.1002/bies.201200119).	ACTR3 ACTR2	9.68e-06	3	63	2	25264243
Pubmed	Membrane trafficking RNA interference screen identifies a crucial role of the clathrin endocytic pathway and ARP2/3 complex for Japanese encephalitis virus infection in HeLa cells.	ACTR3 ACTR2	9.68e-06	3	63	2	30489239
Pubmed	Actin-filament cross-linking protein T-plastin increases Arp2/3-mediated actin-based movement.	ACTR3 ACTR2	9.68e-06	3	63	2	15741236
Pubmed	Involvement of Arp2/3 complex in MCP-1-induced chemotaxis.	ACTR3 ACTR2	9.68e-06	3	63	2	16004967
Pubmed	A WAVE2-Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens.	ACTR3 ACTR2	9.68e-06	3	63	2	23051739
Pubmed	Non-genomic activities of retinoic acid receptor alpha control actin cytoskeletal events in human platelets.	ACTR3 ACTR2	9.68e-06	3	63	2	26848712
Pubmed	Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells.	GPR68 GPR132	9.68e-06	3	63	2	15665078
Pubmed	Nuclear role of WASp in gene transcription is uncoupled from its ARP2/3-dependent cytoplasmic role in actin polymerization.	ACTR3 ACTR2	9.68e-06	3	63	2	24872192
Pubmed	Involvement of the Arp2/3 complex and Scar2 in Golgi polarity in scratch wound models.	ACTR3 ACTR2	9.68e-06	3	63	2	12589062
Pubmed	Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes.	ACTR3 ACTR2	9.68e-06	3	63	2	9000076
Pubmed	Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8.	NPBWR1 NPBWR2	9.68e-06	3	63	2	12130646
Pubmed	Palladin Compensates for the Arp2/3 Complex and Supports Actin Structures during Listeria Infections.	ACTR3 ACTR2	9.68e-06	3	63	2	29636431
Pubmed	Neural Wiskott Aldrich Syndrome Protein (N-WASP) and the Arp2/3 complex are recruited to sites of clathrin-mediated endocytosis in cultured fibroblasts.	ACTR3 ACTR2	9.68e-06	3	63	2	15085951
Pubmed	ox-LDL induces endothelial dysfunction by promoting Arp2/3 complex expression.	ACTR3 ACTR2	9.68e-06	3	63	2	27181356
Pubmed	ARPC5 isoforms and their regulation by calcium-calmodulin-N-WASP drive distinct Arp2/3-dependent actin remodeling events in CD4 T cells.	ACTR3 ACTR2	9.68e-06	3	63	2	37162507
Pubmed	The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility.	ACTR3 ACTR2	9.68e-06	3	63	2	19262673
Pubmed	Distinct roles for the actin nucleators Arp2/3 and hDia1 during NK-mediated cytotoxicity.	ACTR3 ACTR2	9.68e-06	3	63	2	19913427
Pubmed	Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent Nephronophthisis.	MAPKBP1 WDR62	9.68e-06	3	63	2	28089251
Pubmed	Normal Arp2/3 complex activation in platelets lacking WASp.	ACTR3 ACTR2	9.68e-06	3	63	2	12200375
Pubmed	Phagocytosis of Aspergillus fumigatus by Human Bronchial Epithelial Cells Is Mediated by the Arp2/3 Complex and WIPF2.	ACTR3 ACTR2	9.68e-06	3	63	2	30792969
Pubmed	Interaction of cortactin and N-WASp with Arp2/3 complex.	ACTR3 ACTR2	9.68e-06	3	63	2	12176354
Pubmed	cAMP signaling by anthrax edema toxin induces transendothelial cell tunnels, which are resealed by MIM via Arp2/3-driven actin polymerization.	ACTR3 ACTR2	9.68e-06	3	63	2	22100162
Pubmed	Human and mouse proteases: a comparative genomic approach.	MED20 USP31 RHBDF2 PRSS48	1.46e-05	81	63	4	12838346
Pubmed	Haematopoietic lineage cell-specific protein 1 (HS1) promotes actin-related protein (Arp) 2/3 complex-mediated actin polymerization.	ACTR3 ACTR2	1.93e-05	4	63	2	12534372
Pubmed	Interaction of SPIN90 with the Arp2/3 complex mediates lamellipodia and actin comet tail formation.	ACTR3 ACTR2	1.93e-05	4	63	2	16253999
Pubmed	G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.	NPBWR1 NPBWR2	1.93e-05	4	63	2	15797961
Pubmed	Dynamic maintenance of asymmetric meiotic spindle position through Arp2/3-complex-driven cytoplasmic streaming in mouse oocytes.	ACTR3 ACTR2	1.93e-05	4	63	2	21874009
Pubmed	Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors.	GPR68 GPR132	1.93e-05	4	63	2	32948783
Pubmed	Identification and analysis of a novel dimerization domain shared by various members of c-Jun N-terminal kinase (JNK) scaffold proteins.	MAPKBP1 WDR62	1.93e-05	4	63	2	23341463
Pubmed	Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse.	ADGRF4 ADGRF1	1.93e-05	4	63	2	22837050
Pubmed	IQGAP1 stimulates actin assembly through the N-WASP-Arp2/3 pathway.	ACTR3 ACTR2	1.93e-05	4	63	2	17085436
Pubmed	Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.	NPBWR1 NPBWR2	1.93e-05	4	63	2	12719537
Pubmed	WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2.	ACTR3 ACTR2	1.93e-05	4	63	2	18516090
Pubmed	Sequential interaction of actin-related proteins 2 and 3 (Arp2/3) complex with neural Wiscott-Aldrich syndrome protein (N-WASP) and cortactin during branched actin filament network formation.	ACTR3 ACTR2	1.93e-05	4	63	2	12732638
Pubmed	Aldolase sequesters WASP and affects WASP/Arp2/3-stimulated actin dynamics.	ACTR3 ACTR2	1.93e-05	4	63	2	23495010
Pubmed	Motility determinants in WASP family proteins.	ACTR3 ACTR2	1.93e-05	4	63	2	12429845
Pubmed	Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens.	ACTR3 ACTR2	1.93e-05	4	63	2	24469447
Pubmed	Advillin acts upstream of phospholipase C ϵ1 in steroid-resistant nephrotic syndrome.	ACTR3 ACTR2	1.93e-05	4	63	2	29058690
Pubmed	Stable association between G alpha(q) and phospholipase C beta 1 in living cells.	AVPR1A GPR68 GPRC6A GPR132	2.75e-05	95	63	4	16754659
Pubmed	Inhibition of the Rac1-WAVE2-Arp2/3 signaling pathway promotes radiosensitivity via downregulation of cofilin-1 in U251 human glioma cells.	ACTR3 ACTR2	3.22e-05	5	63	2	27052944
Pubmed	A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex.	ACTR3 ACTR2	3.22e-05	5	63	2	12872157
Pubmed	Rac interacts with Abi-1 and WAVE2 to promote an Arp2/3-dependent actin recruitment during chlamydial invasion.	ACTR3 ACTR2	3.22e-05	5	63	2	17501982
Pubmed	Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization.	ACTR3 ACTR2	3.22e-05	5	63	2	10563804
Pubmed	Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.	NPBWR1 NPBWR2	3.22e-05	5	63	2	12401809
Pubmed	Activation of p61Hck triggers WASp- and Arp2/3-dependent actin-comet tail biogenesis and accelerates lysosomes.	ACTR3 ACTR2	3.22e-05	5	63	2	17500055
Pubmed	α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3.	ACTR3 ACTR2	3.22e-05	5	63	2	26370503
Pubmed	An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability.	ACTR3 ACTR2	3.22e-05	5	63	2	20404198
Pubmed	Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex.	ACTR3 ACTR2	3.22e-05	5	63	2	11052943
Pubmed	Sequential actin-based pushing forces drive meiosis I chromosome migration and symmetry breaking in oocytes.	ACTR3 ACTR2	3.22e-05	5	63	2	23439682
Pubmed	Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating.	ACTR3 ACTR2	3.22e-05	5	63	2	26997484
Pubmed	GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex.	ACTR3 ACTR2	4.82e-05	6	63	2	10781580
Pubmed	Suppressive action of miRNAs to ARP2/3 complex reduces cell migration and proliferation via RAC isoforms in Hirschsprung disease.	ACTR3 ACTR2	4.82e-05	6	63	2	26991540
Pubmed	WASH complex regulates Arp2/3 complex for actin-based polar body extrusion in mouse oocytes.	ACTR3 ACTR2	4.82e-05	6	63	2	24998208
Pubmed	Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor.	GPR68 GPR132	4.82e-05	6	63	2	15927955
Pubmed	Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex.	ACTR3 ACTR2	6.74e-05	7	63	2	9889097
Pubmed	Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation.	SLC2A8 SLC2A6	6.74e-05	7	63	2	12554125
Pubmed	There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini.	ADGRE4P ADGRA1	6.74e-05	7	63	2	12565841
Pubmed	Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity.	ACTR3 ACTR2	6.74e-05	7	63	2	11741539
Pubmed	Identification of G protein-coupled receptor genes from the human genome sequence.	GPRC6A ADGRF1 GPR148	8.13e-05	46	63	3	12044878
Pubmed	Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions.	ADGRF4 ADGRF1	8.98e-05	8	63	2	12435584
Pubmed	Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex.	ACTR3 ACTR2	8.98e-05	8	63	2	10381382
Pubmed	Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex.	ACTR3 ACTR2	8.98e-05	8	63	2	11018051
Cytoband	12q23	APAF1 UTP20	2.77e-05	6	63	2	12q23
Cytoband	4q31.3	DCLK2 PRSS48	8.40e-04	31	63	2	4q31.3
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	IGSF22 OR52A4P OR52H1 PRMT3 OR52J3	1.07e-03	564	63	5	chr11p15
Cytoband	6p12.3	ADGRF4 ADGRF1	1.13e-03	36	63	2	6p12.3
Cytoband	Ensembl 112 genes in cytogenetic band chr3q21	MYLK SLC49A4 UROC1	1.42e-03	160	63	3	chr3q21
Cytoband	15q15.1	MAPKBP1 BAHD1	1.93e-03	47	63	2	15q15.1
Cytoband	11p15.4	OR52A4P OR52H1 OR52J3	2.67e-03	200	63	3	11p15.4
Cytoband	11p15.1	IGSF22 PRMT3	3.12e-03	60	63	2	11p15.1
Cytoband	7q36.1	ACTR3C ACTR3B	4.70e-03	74	63	2	7q36.1
GeneFamily	Solute carriers	SLC6A6 SLCO5A1 SLC2A8 SLC39A9 SLC15A4 SLC2A6 SLC49A4 SLC49A3 SLC25A47	9.82e-07	395	49	9	752
GeneFamily	Adhesion G protein-coupled receptors, subfamily F	ADGRF4 ADGRF1	7.16e-05	5	49	2	916
GeneFamily	Actin related protein 2/3 complex	ACTR3 ACTR2	2.56e-04	9	49	2	39
GeneFamily	Olfactory receptors, family 52	OR52A4P OR52H1 OR52J3	3.16e-04	49	49	3	165
GeneFamily	Neuropeptide receptors	NPBWR1 NPBWR2	3.19e-04	10	49	2	854
GeneFamily	G protein-coupled receptors, Class A orphans	GPR68 GPR132 GPR148	1.23e-03	78	49	3	262
ToppCell	COVID-19-kidney-CD-IC-B\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AVPR1A ACTR3C ADGRA1 GPRC6A DCLK2 ADGRF1	2.26e-07	182	63	6	ee6a8c356bbbdae55e4ea858337e079491f9f4aa
ToppCell	COVID-19-kidney-CD-IC-B\|kidney / Disease (COVID-19 only), tissue and cell type	AVPR1A ADGRA1 GPRC6A DCLK2 ADGRF1	6.80e-06	187	63	5	ce05b89860573fe0356102e2998d1ef6d1968034
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	RHBDF2 SLC15A4 UTP20 BAHD1 HPS3	7.53e-06	191	63	5	39ef8e1d7cc3ebb11717e8a55501515e3b72b177
Disease	primary autosomal recessive microcephaly 2 with or without cortical malformations (implicated_via_orthology)	MAPKBP1 WDR62	3.93e-06	2	59	2	DOID:0070293 (implicated_via_orthology)
Disease	autoimmune disease (implicated_via_orthology)	GPR132 CD200	2.35e-05	4	59	2	DOID:417 (implicated_via_orthology)
Disease	microcephaly (implicated_via_orthology)	MAPKBP1 WDR62	1.88e-03	32	59	2	DOID:10907 (implicated_via_orthology)
Disease	alcohol use disorder measurement, longitudinal alcohol consumption measurement	ADH6 DCLK2	2.50e-03	37	59	2	EFO_0007645, EFO_0009458
Disease	colorectal carcinoma (is_marker_for)	ACTR3 ACTR2	2.50e-03	37	59	2	DOID:0080199 (is_marker_for)
Disease	Parkinson disease, disease progression measurement	ANO2 AQP10	2.78e-03	39	59	2	EFO_0008336, MONDO_0005180
Disease	Charcot-Marie-Tooth disease	EGR2 MORC2	3.21e-03	42	59	2	cv:C0007959
Disease	high grade glioma (implicated_via_orthology)	MAPKBP1 WDR62	3.52e-03	44	59	2	DOID:3070 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ITSYVRTVLCEGGVP	APAF1	106	O14727
GYGCPLIISVITIAV	ADGRF1	706	Q5T601
SYGVCVVVGVLPASV	ADH6	286	P28332
HVIPVAEGYVIGSCI	ACTR3B	176	Q9P1U1
YGIPAVIIAVSAIVG	ADGRE4P	306	Q86SQ3
IGYGCPLIIAVTTVA	ADGRF4	521	Q8IZF3
YLVSGGVPFIICGVT	ADGRA1	136	Q86SQ6
VVAPLVGATVGTATY	AQP10	246	Q96PS8
PSSVIGVIVFLYGCA	ANO2	376	Q9NQ90
LALTVGGAYIVCINP	DISP1	726	Q96F81
VVDSGDGVTHICPVY	ACTR2	156	P61160
IPICSLYGAAVTTVE	AOX1	76	Q06278
SCYPEGIINIVSAGI	EGR2	106	P11161
SLSGIEICYTAVVVP	OR10W1	56	Q8NGF6
SIGVICYILVSGLSP	MYLK	1646	Q15746
THVIPVAEGYVIGSC	ACTR3C	46	Q9C0K3
AYVCQAVIIPPEVTG	ELAPOR1	736	Q6UXG2
VCGTPTYVAPEIIAE	DCLK2	551	Q8N568
LIPYVVTATGRVLCG	MAP3K6	176	O95382
IGIPFCATYVIALIG	OR52A4P	31	A6NMU1
GGLTAACIPVYVSEI	SLC2A6	146	Q9UGQ3
VLLPAVYSGICAVGL	NPBWR2	46	P48146
ACGGVVGVVDVPYLV	MORC2	406	Q9Y6X9
ISGTACLTVYVQPIV	CD200	131	P41217
TPVVKSSGGLRVCYV	GPRC6A	621	Q5T6X5
HVIPVAEGYVIGSCI	ACTR3	176	P61158
CAYVGDIVDIPGTSV	ADAMTS3	146	O15072
KIPISGTCYTVGGLI	IGSF22	851	Q8N9C0
YSEVIVVVGGCERVG	KLHL24	311	Q6TFL4
GSVYPDICTISLVAV	PRMT3	356	O60678
YVVKSVPGCEGVALV	FCGBP	346	Q9Y6R7
ETVYPVPEGITCGVV	SLC49A4	406	Q96SL1
PGCGLLVIVTYTSIL	GPR148	211	Q8TDV2
RTYGDVVVPVANCGV	JMJD4	131	Q9H9V9
VNGYSICGVLPLSVT	BAHD1	446	Q8TBE0
VGYGCPLAIAAITVA	ADGRF2	566	Q8IZF7
SGLVAYPAGCVVVLF	MAPKBP1	61	O60336
VVCVYGGTGISEQIA	DDX46	476	Q7L014
SFVTGYAIPTVCVGL	SLC15A4	221	Q8N697
VGCYVAGIIPLAVNF	SLC39A9	16	Q9NUM3
PVVYAVICAVGLAGN	NPBWR1	41	P48145
TLGATVCYPVQSVII	APOOL	146	Q6UXV4
RGISVEVEYGPCVVA	MED20	136	Q9H944
VVYVTVLVVGFPANC	GPR68	26	Q15743
GIPFCIIYIVAVVGN	OR52H1	36	Q8NGJ2
TCGAHVGVICVFYIP	OR52J3	241	Q8NH60
VVVYSAVCTLGVPAN	GPR132	46	Q9UNW8
ITCVTIIPSAIGNYI	TAS2R16	136	Q9NYV7
VTGCVYPGIAENIGE	UTP20	1276	O75691
ICPLFSGIGYASVVI	SLC6A6	116	P31641
ITPVEVSFCVGYVAV	HPS3	186	Q969F9
VTGLDTCYPERVVGV	NKPD1	236	Q17RQ9
GLACGVASLVAPVYI	SLC2A8	131	Q9NY64
SIYTGVIIVPSAGVG	SLCO5A1	471	Q9H2Y9
VCGVAVGYPLDTVKV	SLC25A47	11	Q6Q0C1
YRVVATAPGCGVIEC	PI4KAP2	371	A4QPH2
LGVYTIPAGVVCLLS	SLC49A3	196	Q6UXD7
CYIGPQGIVHGTVLT	UROC1	211	Q96N76
TEPVGVVCRVDGVYQ	UAP1	286	Q16222
VAPVVILGTCYGFIC	AVPR1A	226	P37288
ISVCGQPVYSSRVVG	PRSS48	16	Q7RTY5
GTGHVAYLAGCVVVI	WDR62	81	O43379
CPFSLRVVSVVGITY	USP31	511	Q70CQ4
TLLVICTYGIAPVGF	RHBDF2	416	Q6PJF5