Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbenzodiazepine receptor binding

RIMBP3 RIMBP3C RIMBP3B

7.43e-085403GO:0030156
GeneOntologyMolecularFunctionheparin binding

FGFR1 CEL ADAMTSL5 HDGF

5.78e-04192404GO:0008201
GeneOntologyMolecularFunctionfibroblast growth factor binding

FGFR1 SCN5A

1.33e-0327402GO:0017134
GeneOntologyMolecularFunctionglycosaminoglycan binding

FGFR1 CEL ADAMTSL5 HDGF

1.98e-03268404GO:0005539
GeneOntologyCellularComponentmanchette

RIMBP3 RIMBP3C RIMBP3B

1.90e-0528393GO:0002177
MousePhenoectopic manchette

RIMBP3 RIMBP3C RIMBP3B

1.24e-0519343MP:0009377
MousePhenodetached sperm flagellum

RIMBP3 RIMBP3C RIMBP3B

1.70e-0521343MP:0008893
MousePhenothick retina inner plexiform layer

DSCAM DSCAML1

1.72e-053342MP:0014265
MousePhenoimpaired fertilization

KPNA4 RIMBP3 RIMBP3C ZAN RIMBP3B

1.30e-04206345MP:0000242
MousePhenoincreased sensory neuron number

FGFR1 DSCAM DSCAML1

1.32e-0441343MP:0006006
MousePhenodetached acrosome

RIMBP3 RIMBP3C RIMBP3B

1.63e-0444343MP:0009231
MousePhenoabnormal manchette morphology

RIMBP3 RIMBP3C RIMBP3B

1.74e-0445343MP:0009376
MousePhenoabnormal fertilization

KPNA4 RIMBP3 RIMBP3C ZAN RIMBP3B

1.81e-04221345MP:0005410
MousePhenokinked sperm flagellum

RIMBP3 RIMBP3C RIMBP3B

3.34e-0456343MP:0009237
DomainFN3

RIMBP3 OBSL1 RIMBP3C RIMBP3B DSCAM DSCAML1

3.30e-06199396PS50853
DomainFN3_dom

RIMBP3 OBSL1 RIMBP3C RIMBP3B DSCAM DSCAML1

4.38e-06209396IPR003961
DomainSH3_9

RIMBP3 TNK2 RIMBP3C RIMBP3B

2.07e-0578394PF14604
DomainFN3

OBSL1 RIMBP3C RIMBP3B DSCAM DSCAML1

3.96e-05185395SM00060
Domain-

RIMBP3 OBSL1 RIMBP3C FGFR1 RIMBP3B DSCAM DSCAML1

3.93e-046633972.60.40.10
DomainIg-like_fold

RIMBP3 OBSL1 RIMBP3C FGFR1 RIMBP3B DSCAM DSCAML1

5.73e-04706397IPR013783
DomainIg_I-set

OBSL1 FGFR1 DSCAM DSCAML1

6.46e-04190394IPR013098
Domainig

OBSL1 FGFR1 DSCAM DSCAML1

6.46e-04190394PF00047
DomainImmunoglobulin

OBSL1 FGFR1 DSCAM DSCAML1

6.46e-04190394IPR013151
DomainI-set

OBSL1 FGFR1 DSCAM DSCAML1

6.46e-04190394PF07679
DomainSH3_2

RIMBP3 RIMBP3C RIMBP3B

7.64e-0486393IPR011511
DomainSH3_2

RIMBP3 RIMBP3C RIMBP3B

7.64e-0486393PF07653
DomainRHO

RHOBTB1 RHOBTB2

7.88e-0420392PS51420
DomainSH3

RIMBP3 TNK2 RIMBP3C RIMBP3B

1.04e-03216394SM00326
DomainSH3

RIMBP3 TNK2 RIMBP3C RIMBP3B

1.04e-03216394PS50002
DomainSH3_domain

RIMBP3 TNK2 RIMBP3C RIMBP3B

1.12e-03220394IPR001452
DomainIGc2

OBSL1 FGFR1 DSCAM DSCAML1

1.42e-03235394SM00408
DomainIg_sub2

OBSL1 FGFR1 DSCAM DSCAML1

1.42e-03235394IPR003598
Domainfn3

OBSL1 DSCAM DSCAML1

4.66e-03162393PF00041
DomainDnaJ_domain

PDCD2L GAK

5.08e-0351392IPR001623
DomainIGv

DSCAM DSCAML1

1.07e-0275392SM00406
DomainIG

OBSL1 FGFR1 DSCAM DSCAML1

1.12e-02421394SM00409
DomainIg_sub

OBSL1 FGFR1 DSCAM DSCAML1

1.12e-02421394IPR003599
Pubmed

RIM-BP3 is a manchette-associated protein essential for spermiogenesis.

RIMBP3 RIMBP3C RIMBP3B

5.63e-09440319091768
Pubmed

Structure and evolution of RIM-BP genes: identification of a novel family member.

RIMBP3 RIMBP3C RIMBP3B

1.41e-08540317855024
Pubmed

Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.

RIMBP3 RIMBP3C RIMBP3B

5.08e-071440317662146
Pubmed

Macrophages, but not T and B lymphocytes, are critical for subepidermal blister formation in experimental bullous pemphigoid: macrophage-mediated neutrophil infiltration depends on mast cell activation.

RAG1 KITLG

1.29e-06240212244200
Pubmed

Human down syndrome cell adhesion molecules (DSCAMs) are functionally conserved with Drosophila Dscam[TM1] isoforms in controlling neurodevelopment.

DSCAM DSCAML1

1.29e-06240221645617
Pubmed

DSCAM and DSCAML1 regulate the radial migration and callosal projection in developing cerebral cortex.

DSCAM DSCAML1

1.29e-06240225451118
Pubmed

Cardiac sodium channel Na(v)1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1.

PTPN3 SCN5A

1.29e-06240216930557
Pubmed

Mammalian DSCAMs: roles in the development of the spinal cord, cortex, and cerebellum?

DSCAM DSCAML1

1.29e-06240212051741
Pubmed

Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma.

RAG1 PIK3CG

1.29e-06240210972292
Pubmed

The Dictyostelium discoideum family of Rho-related proteins.

RHOBTB1 RHOBTB2

3.87e-06340211222756
Pubmed

Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis.

RHOBTB1 RHOBTB2

3.87e-06340227314390
Pubmed

Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1-PI3K-Rac1 pathway.

FGFR1 PIK3CG

3.87e-06340220606682
Pubmed

Replacing the PDZ-interacting C-termini of DSCAM and DSCAML1 with epitope tags causes different phenotypic severity in different cell populations.

DSCAM DSCAML1

3.87e-06340227637097
Pubmed

Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse.

RHOBTB1 RHOBTB2

3.87e-06340212426103
Pubmed

Activated cdc42-associated kinase is up-regulated in non-small-cell lung cancer and necessary for FGFR-mediated AKT activation.

TNK2 FGFR1

3.87e-06340225945695
Pubmed

ACTH treatment promotes murine cardiac allograft acceptance.

RAG1 PIK3CG

7.73e-06440234236047
Pubmed

Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3K/Akt pathway.

KITLG PIK3CG

7.73e-06440217410437
Pubmed

Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ.

RAG1 PIK3CG

7.73e-06440229038423
Pubmed

Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism.

RHOBTB1 RHOBTB2

1.29e-05540218835386
Pubmed

MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein.

RHOBTB1 RHOBTB2

1.93e-05640222709582
Pubmed

Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain.

RHOBTB1 RHOBTB2

3.60e-05840224923387
Pubmed

P110delta, a novel phosphoinositide 3-kinase in leukocytes.

KITLG PIK3CG

5.77e-05104029113989
Pubmed

Cytokine gene expression in murine fetal intestine: potential for extrathymic T cell development.

RAG1 KITLG

5.77e-05104029619371
Pubmed

Subtle Roles of Down Syndrome Cell Adhesion Molecules in Embryonic Forebrain Development and Neuronal Migration.

DSCAM DSCAML1

5.77e-051040233585465
Pubmed

The roles of FGF signaling in germ cell migration in the mouse.

FGFR1 KITLG

8.45e-051240216291796
Pubmed

DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina.

DSCAM DSCAML1

1.16e-041440219945391
Pubmed

DSCAM promotes axon fasciculation and growth in the developing optic pathway.

DSCAM DSCAML1

1.16e-041440228137836
Pubmed

Fgf8 controls regional identity in the developing thalamus.

FGFR1 KITLG

1.73e-041740218653561
Pubmed

The contribution of de novo coding mutations to autism spectrum disorder.

SRCAP DSCAM

1.95e-041840225363768
Pubmed

Comparative mapping of distal murine chromosome 11 and human 17q21.3 in a region containing a modifying locus for murine plasma von Willebrand factor level.

CLDND1 HOXB4

2.67e-04214029806826
Pubmed

FGF9 suppresses meiosis and promotes male germ cell fate in mice.

FGFR1 KITLG

2.94e-042240220833365
Pubmed

Gene-environment interaction impacts on heart development and embryo survival.

FGFR1 SCN5A

2.94e-042240230787001
Pubmed

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.

RAG1 FGFR1

3.50e-04244029096311
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

RIMBP3 TBC1D8 OBSL1 GAK SRCAP

5.48e-0458840538580884
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

OBSL1 TNK2 PTPN3 GAK FGFR1 GTF3C1

5.67e-0491040636736316
Pubmed

A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs.

SRCAP HDGF

7.49e-043540220946988
Pubmed

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.

DGKA FGFR1 KITLG PIK3CG

8.60e-0437140425241761
Pubmed

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.

OBSL1 DSCAM DSCAML1

8.64e-0416240325826454
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

RAG1 TNK2 FGFR1 RHOBTB1

8.68e-0437240422939624
Pubmed

Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.

KPNA4 RNASET2

9.30e-043940224556642
Cytoband22q11.21

RIMBP3 RIMBP3C RIMBP3B

1.27e-0411140322q11.21
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

OBSL1 FGFR1 DSCAM DSCAML1

7.77e-05161264593
GeneFamilyRho family GTPases

RHOBTB1 RHOBTB2

3.72e-0420262390
GeneFamilyImmunoglobulin like domain containing

OBSL1 DSCAM DSCAML1

2.60e-03193263594
GeneFamilyBasic leucine zipper proteins|BTB domain containing

RHOBTB1 RHOBTB2

1.58e-02134262861
GeneFamilyFibronectin type III domain containing

DSCAM DSCAML1

2.20e-02160262555
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-dn_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DGKA CLDND1 PTPN3 FGFR1

1.04e-05152404405d19b290232bb3e564d61c0cff0cfdd247bdff
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-dn_T-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DGKA CLDND1 PTPN3 FGFR1

1.04e-0515240406fa7d8acc8f56de00af9bee17884595b300410e
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-dn_T|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

DGKA CLDND1 PTPN3 FGFR1

1.07e-05153404b101cb1bce5db785dab46b6c4f7be9c3efe48b0e
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-dn_T-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DGKA CLDND1 PTPN3 FGFR1

1.07e-05153404487388082bb596809ba1caf9197626b6814792ab
ToppCellCOVID-19_Severe-Lymphoid_T/NK-dn_T|COVID-19_Severe / Disease group, lineage and cell class

DGKA CLDND1 PTPN3 FGFR1

1.15e-0515640483f25683e0f55472b56f915ee176fc05efc33a31
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-early_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMRN2 RAG1 RHOBTB1 DSCAM

1.85e-0517640488ca2f83d8301633232735f39b0683efe49d0b86
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-early_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMRN2 RAG1 RHOBTB1 DSCAM

1.85e-051764047292e014b8f697f0c2e9f47c48333de95cb44a69
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c13-HAVCR2|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CLDND1 PTPN3 FGFR1 DSCAML1

2.11e-051824046c9a48037fa002bc528875538bdaaf15696d68b6
ToppCellT_cells-Treg_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

TBC1D8 DGKA LDLRAP1 FGFR1

2.88e-05197404ec9398ae3577f61d6b1e6aba50ef4261aaaa7610
DrugSulfathiazole [72-14-0]; Up 200; 15.6uM; HL60; HG-U133A

DGKA TNK2 GAK GTF3C1 SRCAP CEL

8.78e-071983861963_UP
Diseasedevelopmental and epileptic encephalopathy 64 (implicated_via_orthology)

RHOBTB1 RHOBTB2

1.37e-062352DOID:0070375 (implicated_via_orthology)
DiseaseDown syndrome (implicated_via_orthology)

DSCAM DSCAML1

1.42e-0415352DOID:14250 (implicated_via_orthology)
DiseaseRS-warfarin measurement

PTPN3 DSCAML1 SCN5A

4.71e-04128353EFO_0803325

Protein segments in the cluster

PeptideGeneStartEntry
IPKWSPLSEMHPVDY

ARSK

241

Q6UWY0
PSRMPVYPKWVGADH

CEL

441

P19835
MQEHRKVPFAWCAPE

TNK2

286

Q07912
PCEVYFPRNVTMEWH

RAG1

191

P15918
IPEDFFMCHRWPETP

RIMBP3B

1181

A6NNM3
IPEDFFMCHRWPETP

RIMBP3C

1181

A6NJZ7
AYWLVHRCPPGMDNV

RGS9

186

O75916
RTKCHQYWPDPPDVM

PTPN3

751

P26045
MHYAQCLSPVDWDKP

LDLRAP1

281

Q5SW96
RCYVMGKPEPEIEWH

OBSL1

266

O75147
CPHLPWRAKNPYEEA

MGAT5

196

Q09328
DPVGRNWCPYPMSKL

MMRN2

51

Q9H8L6
KSCWPPNHQTPMEEF

PDCD2L

331

Q9BRP1
HFWESCPRPFESRMP

FAM47B

381

Q8NA70
KGYPHWPARIDEMPE

HDGF

21

P51858
HMWRPKRFPRPVYCN

DGKA

206

P23743
PVWMPTRHLKFYNEP

HERVK_113

846

P63132
REYVWAPGHCPCPML

ADAMTSL5

416

Q6ZMM2
PSHSACKEPVVYPWM

HOXB4

131

P17483
MKRCPPGIWPSHKRY

GAK

541

O14976
MCKVYSDPQPHIQWL

FGFR1

276

P11362
CSVDGYPPPKVMWKH

DSCAML1

711

Q8TD84
YPRPPLCAMSWREHA

CFAP107

166

Q8N1D5
AICNPLHYDVVMKPW

OR1L4

126

Q8NGR5
HPEPDYRWLKDNMPL

DSCAM

251

O60469
IPEDFFMCHRWPETP

RIMBP3

1181

Q9UFD9
MWYPEIKHFCPRAPV

RHOBTB2

121

Q9BYZ6
VFMAQHDPPPWTKYV

SCN5A

146

Q14524
KYVPGMDVLPSHCWI

KITLG

56

P21583
MWYPEIKHFCPRTPV

RHOBTB1

121

O94844
PRPKGHWDYLCEEMQ

SRCAP

131

Q6ZRS2
CITIPKNMHWYSPPE

CLDND1

81

Q9NY35
YAMHPWVTSKPLPEY

PIK3CG

196

P48736
PEMRAYWPDVIHSFP

RNASET2

91

O00584
PEHCIEYVRMLQWPK

UBA3

246

Q8TBC4
QHPMAPYRVLPYCWK

RIBC1

261

Q8N443
WDYMHPFPESKPVLA

SPCS2

101

Q15005
SCYWEQPRPMASRHD

TBC1D8

831

O95759
DDASWMRYIPPIPVH

GTF3C1

881

Q12789
HAVKPWREPHFCPMA

ZAN

1411

Q9Y493
TWVMVNLCRHKDPPP

KPNA4

221

O00629