Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein tyrosine kinase activity	EPHB6 YES1 MET IGF1R AATK FGR HCK MUSK	2.24e-05	145	160	8	GO:0004713
GeneOntologyMolecularFunction	metalloaminopeptidase activity	ERAP1 RNPEP ERAP2 MMP14	5.17e-05	26	160	4	GO:0070006
GeneOntologyMolecularFunction	protein phosphorylated amino acid binding	YES1 YWHAE CRKL FGR HCK	2.31e-04	69	160	5	GO:0045309
GeneOntologyMolecularFunction	metalloexopeptidase activity	NAALAD2 ERAP1 RNPEP ERAP2 MMP14	2.47e-04	70	160	5	GO:0008235
GeneOntologyMolecularFunction	cell adhesion molecule binding	COL5A1 PRTG DSC2 LAMA5 CDH23 ITGAE YWHAE CRKL CDH20 TENM3 CD226 KIRREL1 MMP14 CDH12	3.40e-04	599	160	14	GO:0050839
GeneOntologyMolecularFunction	protein kinase activity	EPHB6 YES1 MLKL MET FAM20C IGF1R AATK MAST4 GUCY2D BUB1B FGR FAM20A HCK MUSK	3.46e-04	600	160	14	GO:0004672
GeneOntologyMolecularFunction	aminopeptidase activity	ERAP1 RNPEP ERAP2 MMP14	3.84e-04	43	160	4	GO:0004177
GeneOntologyMolecularFunction	kinase activity	EPHB6 YES1 TPK1 MLKL MET FAM20C IGF1R AATK MAST4 N4BP2 GUCY2D BUB1B FGR FAM20A HCK MUSK	4.34e-04	764	160	16	GO:0016301
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	EPHB6 YES1 TPK1 MLKL MET FAM20C IGF1R AATK MAST4 N4BP2 GUCY2D BUB1B FGR FAM20A HCK CTU1 MUSK PARP15	5.36e-04	938	160	18	GO:0016772
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	EPHB6 YES1 MLKL MET FAM20C IGF1R AATK MAST4 N4BP2 GUCY2D BUB1B FGR FAM20A HCK MUSK	5.93e-04	709	160	15	GO:0016773
GeneOntologyMolecularFunction	phosphotyrosine residue binding	YES1 CRKL FGR HCK	7.40e-04	51	160	4	GO:0001784
Domain	Pkinase_Tyr	EPHB6 YES1 MLKL MET IGF1R AATK GUCY2D FGR HCK MUSK	1.85e-07	129	162	10	PF07714
Domain	Ser-Thr/Tyr_kinase_cat_dom	EPHB6 YES1 MLKL MET IGF1R AATK GUCY2D FGR HCK MUSK	3.48e-07	138	162	10	IPR001245
Domain	PROTEIN_KINASE_TYR	YES1 MET IGF1R AATK FGR HCK MUSK	2.17e-05	97	162	7	PS00109
Domain	Tyr_kinase_AS	YES1 MET IGF1R AATK FGR HCK MUSK	2.17e-05	97	162	7	IPR008266
Domain	FGR	YES1 FGR	7.48e-05	2	162	2	IPR028459
Domain	SH3_1	NCF4 YES1 CRKL SH3PXD2B DLG3 OSTF1 FGR HCK	9.36e-05	164	162	8	PF00018
Domain	Tyr_kinase_cat_dom	YES1 MET IGF1R FGR HCK MUSK	1.17e-04	88	162	6	IPR020635
Domain	TyrKc	YES1 MET IGF1R FGR HCK MUSK	1.17e-04	88	162	6	SM00219
Domain	Peptidase_M1	ERAP1 RNPEP ERAP2	1.33e-04	12	162	3	IPR001930
Domain	Peptidase_M1_N	ERAP1 RNPEP ERAP2	1.72e-04	13	162	3	IPR014782
Domain	Peptidase_M1	ERAP1 RNPEP ERAP2	1.72e-04	13	162	3	PF01433
Domain	FAM20_C	FAM20C FAM20A	2.23e-04	3	162	2	IPR009581
Domain	PDED_dom	UNC119B UNC119	2.23e-04	3	162	2	IPR008015
Domain	Fam20C	FAM20C FAM20A	2.23e-04	3	162	2	PF06702
Domain	-	UNC119B UNC119	2.23e-04	3	162	2	2.70.50.40
Domain	FAM20	FAM20C FAM20A	2.23e-04	3	162	2	IPR024869
Domain	GMP_PDE_delta	UNC119B UNC119	2.23e-04	3	162	2	PF05351
Domain	Ig_E-set	UNC119B PKHD1L1 UNC119 MET NFATC2 TGM7	2.92e-04	104	162	6	IPR014756
Domain	LAM_G_DOMAIN	COL5A1 GAS6 LAMA5 PROS1	3.20e-04	38	162	4	PS50025
Domain	Laminin_G_2	COL5A1 GAS6 LAMA5 PROS1	3.91e-04	40	162	4	PF02210
Domain	Growth_fac_rcpt_	EPHB6 NID2 GAS6 LAMA5 IGF1R LRP2 PROS1	4.29e-04	156	162	7	IPR009030
Domain	LamG	COL5A1 GAS6 LAMA5 PROS1	5.65e-04	44	162	4	SM00282
Domain	SH3	NCF4 YES1 CRKL SH3PXD2B DLG3 OSTF1 FGR HCK	6.06e-04	216	162	8	SM00326
Domain	SH3	NCF4 YES1 CRKL SH3PXD2B DLG3 OSTF1 FGR HCK	6.06e-04	216	162	8	PS50002
Domain	-	EPHB6 NDNF COL6A3 PRTG ADAMTSL3 PKHD1L1 IGDCC4 MET SEMA3D IGF1R NFATC2 CD226 KIRREL1 TGM7 MUSK	6.71e-04	663	162	15	2.60.40.10
Domain	SH3_domain	NCF4 YES1 CRKL SH3PXD2B DLG3 OSTF1 FGR HCK	6.83e-04	220	162	8	IPR001452
Domain	U2AF_small	ZRSR2 ZRSR2P1	7.35e-04	5	162	2	IPR009145
Domain	YD	NID2 TENM3	7.35e-04	5	162	2	IPR006530
Domain	Kinase-like_dom	EPHB6 YES1 MLKL MET IGF1R AATK MAST4 GUCY2D BUB1B FGR HCK MUSK SOS1	9.07e-04	542	162	13	IPR011009
Domain	Prot_kinase_dom	EPHB6 YES1 MLKL MET IGF1R AATK MAST4 GUCY2D BUB1B FGR HCK MUSK	1.17e-03	489	162	12	IPR000719
Domain	PROTEIN_KINASE_DOM	EPHB6 YES1 MLKL MET IGF1R AATK MAST4 GUCY2D BUB1B FGR HCK MUSK	1.26e-03	493	162	12	PS50011
Domain	Ig-like_fold	EPHB6 NDNF COL6A3 PRTG ADAMTSL3 PKHD1L1 IGDCC4 MET SEMA3D IGF1R NFATC2 CD226 KIRREL1 TGM7 MUSK	1.26e-03	706	162	15	IPR013783
Domain	Cadherin_C	DSC2 CDH20 CDH12	1.28e-03	25	162	3	PF01049
Domain	Cadherin_cytoplasmic-dom	DSC2 CDH20 CDH12	1.28e-03	25	162	3	IPR000233
Domain	-	COL5A1 GAS6 LAMA5 ADGRV1 PROS1	1.43e-03	95	162	5	2.60.120.200
Domain	cEGF	NID2 GAS6 LRP2	1.44e-03	26	162	3	PF12662
Domain	cEGF	NID2 GAS6 LRP2	1.44e-03	26	162	3	IPR026823
Pubmed	The protein tyrosine kinase family of the human genome.	EPHB6 YES1 MET IGF1R AATK FGR HCK MUSK	6.01e-09	83	164	8	11114734
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KIF13B AARS1 DENND4A PHACTR2 DSC2 RAB11FIP2 YWHAE UNC119 FSIP2 SH3PXD2B IGF1R MDN1 MAST4 N4BP2 BUB1B GNAS MUSK	7.56e-07	861	164	17	36931259
Pubmed	Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells.	YES1 CRKL FGR HCK	8.30e-07	16	164	4	11071635
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	ABCC1 PHACTR2 DSC2 RAB11FIP2 YES1 MET IGF1R TENM3 CIBAR1 KIRREL1 DLG3 CSTPP1	8.47e-07	421	164	12	36976175
Pubmed	Analysis of 5-lipoxygenase phosphorylation on molecular level by MALDI-MS.	YES1 FGR HCK	1.02e-06	5	164	3	24860872
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	COL5A1 ABCC1 GALNT1 MLEC ERAP1 UGGT1 LAMA5 DNAJC18 SSR1 YWHAE CSDE1 MET ATF6 IGF1R TENM3 PGAP1 KIRREL1 TMX3 PLOD2 PROS1	1.09e-06	1201	164	20	35696571
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	ERAP1 LAMA5 MET ATF6 ERAP2 TMX3 MMP14 PLOD2	1.21e-06	164	164	8	32409323
Pubmed	Differential involvement of Src family kinases in Fc gamma receptor-mediated phagocytosis.	YES1 FGR HCK	2.04e-06	6	164	3	10861086
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	SART3 UNC119B ANK2 DSC2 MLEC UGGT1 DNAJC18 SSR1 TTC3 YES1 ACSL3 MET ATF6 MDN1 ERAP2 N4BP2 BUB1B KIRREL1 GNAS TMX3 PLOD2 SF3B2	2.12e-06	1487	164	22	33957083
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	COL5A1 TM7SF3 TRPM2 TSPYL2 GAS6 ADGRV1 TTC3 YWHAE CLDN12 CSDE1 ATF6 IGF1R GPR137C ASMTL VPS41 ANKIB1 RPRD2 OSTF1 GNAS CYB5D1 TMX3 FRMD3	2.17e-06	1489	164	22	28611215
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	GALNT1 GAL3ST1 TRO CHD8 APOB CLDN12 PGM1 TRIM16 CSDE1 SEPTIN8 MET FAM20C MDN1 RNPEP VPS41 ANKIB1 GFM1 PROS1	3.01e-06	1061	164	18	33845483
Pubmed	Proline-rich sequences that bind to Src homology 3 domains with individual specificities.	YES1 FGR HCK	3.55e-06	7	164	3	7536925
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	SART3 AARS1 MLEC UGGT1 YWHAE MTMR10 CRKL ACSL1 ACSL3 ANKRD13A CIBAR1 AGL GNAS TMX3 MMP14 GFM1 SF3B2	3.97e-06	974	164	17	28675297
Pubmed	Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1.	YES1 CRKL FGR HCK	4.70e-06	24	164	4	20624904
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	EPHB6 SART3 COL5A1 COL6A3 PRTG NAALAD2 PHACTR2 ANK2 CHD8 TTC3 JMY HABP4 IGF1R AFAP1L2 FARS2 CFAP20 DLG3 GNAS MED13	5.09e-06	1215	164	19	15146197
Pubmed	Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).	DSC2 ERAP1 UGGT1 LAMA5 YES1 YWHAE FAM20C RNPEP GNAS FAM20A PLOD2	5.14e-06	417	164	11	19199708
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	ABCC1 NID2 AARS1 GALNT1 DSC2 MLEC ERAP1 UGGT1 LAMA5 CHD8 SSR1 YWHAE ACSL1 ACSL3 FARS2 CIBAR1 GNAS GFM1 PLOD2 SF3B2 MITD1	5.18e-06	1451	164	21	30550785
Pubmed	Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis.	YES1 FGR HCK	5.67e-06	8	164	3	16921024
Pubmed	Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.	COL5A1 NID2 COL6A3 LAMA5 APOB RNPEP OSTF1	6.38e-06	146	164	7	27068509
Pubmed	Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome.	YES1 DLG3 OSTF1 FGR HCK	6.90e-06	56	164	5	22745667
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SART3 MLEC LAMA5 CHD8 ADGRV1 SEPTIN8 MAST4 ANKIB1 RPRD2 CACNA1G TMX3 MED13	8.76e-06	529	164	12	14621295
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	COL6A3 ZRSR2 LAMA5 MTMR10 ZRSR2P1 MAB21L3 MDN1 PGAP1 DLG3 CACNA1G	9.59e-06	363	164	10	14691545
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	EPHB6 GALNT1 YES1 YWHAE CRKL ACSL3 IGF1R KAT8 LRP2 KCNS2 TGM7 FGR MMP14 HCK	1.04e-05	730	164	14	34857952
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	EPHB6 AARS1 ANK2 MLEC ZRSR2 TSPYL2 TTC3 YWHAE MTMR10 CSDE1 ATF6 MTA1 USP32 LRP2 SF3B2 MED13 SEZ6L MITD1 SOS1	1.12e-05	1285	164	19	35914814
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	EPHB6 YES1 FBXL3 FBXO38 IGF1R VPS41 KLHL34 FGR HCK MUSK	1.19e-05	372	164	10	22939624
Pubmed	A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function.	CDH23 ADGRV1 PGAP1	1.21e-05	10	164	3	17329413
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	COL5A1 AARS1 MLEC ERAP1 UGGT1 LAMA5 APOB SSR1 YES1 YWHAE CSDE1 ACSL3 MET ATF6 RNPEP CFAP20 GNAS TMX3 PLOD2	1.28e-05	1297	164	19	33545068
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	KIF13B ABCC1 ANK2 DSC2 APOB YES1 MTMR10 MET AFAP1L2 USP32 KIRREL1 DLG3	1.80e-05	569	164	12	30639242
Pubmed	Altered expression of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in transformed non-lymphoid human tissues.	ERAP1 ERAP2	2.21e-05	2	164	2	18393273
Pubmed	Variation in Niemann-Pick C1-like 1 gene as a determinant of apolipoprotein B-100 kinetics and response to statin therapy in centrally obese men.	APOB NPC1L1	2.21e-05	2	164	2	18031309
Pubmed	Replication Study of the Association of GAS6 and PROS1 Polymorphisms with Behçet's Disease in a Japanese Population.	GAS6 PROS1	2.21e-05	2	164	2	37133403
Pubmed	Identification of a homozygous missense mutation in LRP2 and a hemizygous missense mutation in TSPYL2 in a family with mild intellectual disability.	TSPYL2 LRP2	2.21e-05	2	164	2	26529358
Pubmed	Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells.	MET IGF1R	2.21e-05	2	164	2	16891453
Pubmed	Antigenic peptide trimming by ER aminopeptidases--insights from structural studies.	ERAP1 ERAP2	2.21e-05	2	164	2	23545452
Pubmed	ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells.	ZRSR2 ZRSR2P1	2.21e-05	2	164	2	33691379
Pubmed	Duodenal mucosa of untreated celiac disease patients has altered expression of the GAS6 and PROS1 and the negative regulator tyrosine kinase TAM receptors subfamily.	GAS6 PROS1	2.21e-05	2	164	2	38575045
Pubmed	Is there a role for IGF1R and c-MET pathways in resistance to cetuximab in metastatic colorectal cancer?	MET IGF1R	2.21e-05	2	164	2	21729677
Pubmed	IGF1R depletion facilitates MET-amplification as mechanism of acquired resistance to erlotinib in HCC827 NSCLC cells.	MET IGF1R	2.21e-05	2	164	2	28418902
Pubmed	Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity.	FGR HCK	2.21e-05	2	164	2	8125254
Pubmed	Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population.	ERAP1 ERAP2	2.21e-05	2	164	2	32321463
Pubmed	Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis.	ERAP1 ERAP2	2.21e-05	2	164	2	30215709
Pubmed	Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages.	FGR HCK	2.21e-05	2	164	2	10547366
Pubmed	The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues.	ERAP1 ERAP2	2.21e-05	2	164	2	12436110
Pubmed	An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides.	ERAP1 ERAP2	2.21e-05	2	164	2	12436109
Pubmed	ERAP1-ERAP2 haplotypes are associated with ankylosing spondylitis in Polish patients.	ERAP1 ERAP2	2.21e-05	2	164	2	30794838
Pubmed	The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines.	FGR HCK	2.21e-05	2	164	2	26232427
Pubmed	Vitamin K-dependent proteins GAS6 and Protein S and TAM receptors in patients of systemic lupus erythematosus: correlation with common genetic variants and disease activity.	GAS6 PROS1	2.21e-05	2	164	2	23497733
Pubmed	Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions.	FGR HCK	2.21e-05	2	164	2	8666673
Pubmed	Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection.	ERAP1 ERAP2	2.21e-05	2	164	2	20843824
Pubmed	Insulin-like growth factor-1 receptor is associated with better prognosis in classical Hodgkin's lymphoma: Correlation with MET expression.	MET IGF1R	2.21e-05	2	164	2	25916750
Pubmed	Modulation of protein S and growth arrest specific 6 protein signaling inhibits pancreatic cancer cell survival and proliferation.	GAS6 PROS1	2.21e-05	2	164	2	32945517
Pubmed	Truncated apo B-70.5-containing lipoproteins bind to megalin but not the LDL receptor.	APOB LRP2	2.21e-05	2	164	2	10330424
Pubmed	Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I.	IGF1R LRP2	2.21e-05	2	164	2	16306401
Pubmed	ERAP1-ERAP2 dimerization increases peptide-trimming efficiency.	ERAP1 ERAP2	2.21e-05	2	164	2	24928998
Pubmed	Distinct molecular mechanisms leading to deficient expression of ER-resident aminopeptidases in melanoma.	ERAP1 ERAP2	2.21e-05	2	164	2	20419298
Pubmed	Protein S and Gas6 induce efferocytosis of HIV-1-infected cells.	GAS6 PROS1	2.21e-05	2	164	2	29304470
Pubmed	Expression of endoplasmic reticulum aminopeptidases in EBV-B cell lines from healthy donors and in leukemia/lymphoma, carcinoma, and melanoma cell lines.	ERAP1 ERAP2	2.21e-05	2	164	2	16585582
Pubmed	Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis.	ERAP1 ERAP2	2.21e-05	2	164	2	19433412
Pubmed	The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing.	ERAP1 ERAP2	2.21e-05	2	164	2	22106953
Pubmed	Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum.	ERAP1 ERAP2	2.21e-05	2	164	2	15908954
Pubmed	c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration.	FGR HCK	2.21e-05	2	164	2	19903482
Pubmed	Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck.	FGR HCK	2.21e-05	2	164	2	9916742
Pubmed	Synergy of endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) polymorphisms in atopic dermatitis: Effects on disease prevalence.	ERAP1 ERAP2	2.21e-05	2	164	2	33309189
Pubmed	Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile.	ERAP1 ERAP2	2.21e-05	2	164	2	29108111
Pubmed	The association of ERAP1 and ERAP2 single nucleotide polymorphisms and their haplotypes with psoriasis vulgaris is dependent on the presence or absence of the HLA-C*06:02 allele and age at disease onset.	ERAP1 ERAP2	2.21e-05	2	164	2	29183862
Pubmed	An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes.	ERAP1 ERAP2	2.21e-05	2	164	2	29991817
Pubmed	Plasma concentrations of growth arrest-specific protein 6 and protein S in patients with acute pancreatitis.	GAS6 PROS1	2.21e-05	2	164	2	19744001
Pubmed	Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome.	ERAP1 ERAP2	2.21e-05	2	164	2	28063628
Pubmed	The ERAP gene is associated with HCV chronic infection in a Chinese Han population.	ERAP1 ERAP2	2.21e-05	2	164	2	29037997
Pubmed	Fgr deficiency results in defective eosinophil recruitment to the lung during allergic airway inflammation.	FGR HCK	2.21e-05	2	164	2	12055264
Pubmed	Decreased insulin-like growth factor I-mediated protein tyrosine phosphorylation in human olivopontocerebellar atrophy and lurcher mutant mouse.	GRID2 IGF1R	2.21e-05	2	164	2	7931420
Pubmed	GSK1904529A, a Potent IGF-IR Inhibitor, Reverses MRP1-Mediated Multidrug Resistance.	ABCC1 IGF1R	2.21e-05	2	164	2	28266043
Pubmed	Genomic organization of the human adipocyte-derived leucine aminopeptidase gene and its relationship to the placental leucine aminopeptidase/oxytocinase gene.	ERAP1 ERAP2	2.21e-05	2	164	2	11481040
Pubmed	Zrsr2 and functional U12-dependent spliceosome are necessary for follicular development.	ZRSR2 ZRSR2P1	2.21e-05	2	164	2	35198906
Pubmed	Opposite Roles of MerTK Ligands Gas6 and Protein S During Retinal Phagocytosis.	GAS6 PROS1	2.21e-05	2	164	2	29721990
Pubmed	The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities.	ERAP1 ERAP2	2.21e-05	2	164	2	36569828
Pubmed	Met, IGF1R, and other new targets in upper GI malignancies.	MET IGF1R	2.21e-05	2	164	2	23873272
Pubmed	The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine.	FGR HCK	2.21e-05	2	164	2	17339487
Pubmed	ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing.	ERAP1 ERAP2	2.21e-05	2	164	2	27514473
Pubmed	The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating beta 2 integrin affinity and valency in neutrophils, but are required for beta 2 integrin-mediated outside-in signaling involved in sustained adhesion.	FGR HCK	2.21e-05	2	164	2	16785558
Pubmed	A Comparative Review of Pregnancy and Cancer and Their Association with Endoplasmic Reticulum Aminopeptidase 1 and 2.	ERAP1 ERAP2	2.21e-05	2	164	2	36834865
Pubmed	The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia.	ERAP1 ERAP2	2.21e-05	2	164	2	32210971
Pubmed	RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking.	SNX13 GNAS	2.21e-05	2	164	2	11729322
Pubmed	Serum cytokine receptors in ankylosing spondylitis: relationship to inflammatory markers and endoplasmic reticulum aminopeptidase polymorphisms.	ERAP1 ERAP2	2.21e-05	2	164	2	20595269
Pubmed	Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth.	YES1 CRKL	2.21e-05	2	164	2	23318429
Pubmed	ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum.	ERAP1 ERAP2	2.21e-05	2	164	2	17088086
Pubmed	The Mass1frings mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC.	CDH23 ADGRV1	2.21e-05	2	164	2	15820310
Pubmed	Comparative expression profiling for human endoplasmic reticulum-resident aminopeptidases 1 and 2 in normal kidney versus distinct renal cell carcinoma subtypes.	ERAP1 ERAP2	2.21e-05	2	164	2	23696916
Pubmed	Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women.	ERAP1 ERAP2	2.21e-05	2	164	2	33762660
Pubmed	Differential localization of MT1-MMP in human prostate cancer tissue: role of IGF-1R in MT1-MMP expression.	IGF1R MMP14	2.21e-05	2	164	2	18196535
Pubmed	Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.	YES1 CRKL MET FGR HCK	2.54e-05	73	164	5	24728074
Pubmed	MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.	AARS1 ERAP1 SSR1 CSDE1 ACSL3 MET RNPEP	2.67e-05	182	164	7	30711629
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	UNC119B GAS6 YES1 YWHAE TRIM16 UNC119 MLKL MET IGF1R TRMT2A CFAP20 BUB1B OSTF1 HCK SOS1	2.92e-05	910	164	15	36736316
Pubmed	Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.	AARS1 MLEC UGGT1 YWHAE PGM1 ACSL3 RNPEP AGL PLOD2 SF3B2	3.47e-05	422	164	10	27342126
Pubmed	Axotomy-induced target disconnection promotes an additional death mechanism involved in motoneuron degeneration in amyotrophic lateral sclerosis transgenic mice.	APOBEC3D CDH23 APOBEC3B	3.61e-05	14	164	3	24424947
Pubmed	The SRC-family tyrosine kinase HCK shapes the landscape of SKAP2 interactome.	YES1 FGR HCK	3.61e-05	14	164	3	29568343
Pubmed	Membrane-type MMPs are indispensable for placental labyrinth formation and development.	NID2 LAMA5 MMP14	3.61e-05	14	164	3	20858856
Pubmed	Allogeneic B cell immunomodulatory therapy in amyotrophic lateral sclerosis.	APOBEC3D CDH23 APOBEC3B	3.61e-05	14	164	3	38967302
Pubmed	Noradrenergic circuit control of non-REM sleep substates.	APOBEC3D CDH23 APOBEC3B	3.61e-05	14	164	3	34648731
Pubmed	Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning.	APOBEC3D CDH23 APOBEC3B	3.61e-05	14	164	3	35665767
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	MET IGF1R AATK MUSK	1.11e-04	40	113	4	321
GeneFamily	Aminopeptidases\|CD molecules	ERAP1 RNPEP ERAP2	1.52e-04	17	113	3	104
GeneFamily	Apolipoprotein B mRNA editing enzyme catalytic subunits	APOBEC3D APOBEC3B	2.45e-03	12	113	2	406
GeneFamily	Laminin subunits	LAMB4 LAMA5	2.45e-03	12	113	2	626
GeneFamily	Gla domain containing	GAS6 PROS1	2.89e-03	13	113	2	1250
GeneFamily	CD molecules\|Type II classical cadherins	CDH20 CDH12	2.89e-03	13	113	2	1186
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	PRTG ADAMTSL3 IGDCC4 KIRREL1 MUSK	3.41e-03	161	113	5	593
GeneFamily	SH2 domain containing	YES1 CRKL FGR HCK	3.71e-03	101	113	4	741
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	ERAP1 SSR1 APOBEC3B	3.98e-03	51	113	3	870
Coexpression	GSE26928_EFF_MEMORY_VS_CXCR5_POS_CD4_TCELL_DN	SART3 GALNT1 APOB YES1 IGF1R N4BP2 CIBAR1 TGM7 CDH12	3.90e-06	194	164	9	M4687
Coexpression	GSE7460_CD8_TCELL_VS_CD4_TCELL_ACT_UP	NDNF UNC119B DENND4A AGPAT4 YES1 SLC13A1 RNPEP OSTF1 HCK	4.80e-06	199	164	9	M5687
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	ANK2 LAMA5 MCF2 GRID2 TTC3 SLC7A14 PCDH17 FSIP2 AATK MDN1 MAST4 GPR137C ERAP2 N4BP2 PGAP1 ANKIB1 DLG3 CACNA1G SEZ6L FRMD3	2.06e-05	1106	164	20	M39071
Coexpression	GSE46606_IRF4_KO_VS_WT_CD40L_IL2_IL5_3DAY_STIMULATED_BCELL_UP	SYT17 GAS6 PGM1 IGF1R FBP1 MAST4 CD226 SEZ6L	3.42e-05	196	164	8	M9821
Coexpression	GSE29618_LAIV_VS_TIV_FLU_VACCINE_DAY7_MDC_UP	NDNF LAMB4 NAALAD2 GALNT1 PGM1 PCDH17 CSDE1 PLOD2	3.55e-05	197	164	8	M5020
Coexpression	GSE25123_IL4_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_DAY10_UP	NID2 ITGAE CLDN12 KCTD17 UNC119 ATF6 BUB1B FAM20A	3.95e-05	200	164	8	M7962
Coexpression	GSE3982_DC_VS_TH1_UP	DSC2 SYT17 RENBP TTC3 SNX13 CSDE1 VPS41 FGR	3.95e-05	200	164	8	M5481
Coexpression	GSE7460_TCONV_VS_TREG_LN_DN	DENND4A TM7SF3 NCF4 ITGAE SNX13 SEPTIN8 IGF1R PROS1	3.95e-05	200	164	8	M5674
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4\|TCGA-Prostate / Sample_Type by Project: Shred V9	TNFAIP8L3 TRO GAS6 AGPAT4 NLRP1 KCTD17 MET SH3PXD2B KIRREL1 MMP14	3.05e-09	195	164	10	5562665dd3beb70e2358aa32611a337bef5731c1
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF13B MGAM SPATA6L SYT17 TM7SF3 RAB11FIP2 FAM20C TENM3 FAM20A	4.55e-08	194	164	9	04bfc555743f7d8821439d05ae442d15e9886c59
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma-early_osteoblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	NDNF COL5A1 COL6A3 PRTG FAM20C SH3PXD2B TENM3 KIRREL1 PLOD2	5.91e-08	200	164	9	16a7c398626b6e82b394eb3ef013bda3a788659d
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	KIF13B GAL3ST1 GRID2 ADGRV1 PCDH17 AFAP1L2 PHOX2B FRMD3	3.92e-07	182	164	8	b4fc5e4f5d8440a3c9ee0a6fd0da87b43cabc8c6
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL5A1 TBX3 ISM1 ACSL3 HABP4 NFATC2 GPR137C PGAP1	3.92e-07	182	164	8	ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCell	ILEUM-non-inflamed-(7)_Endothelial_cell-(7)_Lymphatics\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	TNFAIP8L3 ANK2 ADAMTSL3 PKHD1L1 KCTD17 SEMA3D TENM3 GNAS	5.43e-07	190	164	8	9ce301841ce9486701fa28eb2a9929e35d476878
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 COL6A3 NAALAD2 CDH23 GRID2 ADAMTSL3 SH3PXD2B NFATC2	5.65e-07	191	164	8	2c51850f5c559d665b8a27a12b75af9ed58dffe1
ToppCell	facs-Lung-nan-3m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID2 ANK2 YES1 PKHD1L1 KCTD17 SEMA3D SEZ6L PROS1	5.65e-07	191	164	8	48823a97c38263f2c6e58348214f5b62773a6368
ToppCell	facs-Lung-nan-3m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID2 ANK2 YES1 PKHD1L1 KCTD17 SEMA3D SEZ6L PROS1	5.65e-07	191	164	8	0eedc66e967b1837ce2c14f8c14b3c1eba868c76
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EPHB6 PRTG PHACTR2 GRID2 ADAMTSL3 TENM3 FAM20A FRMD3	6.11e-07	193	164	8	658c2b30a4d806c5ce78ea4392fe8eb86b8d1e99
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EPHB6 PRTG PHACTR2 GRID2 ADAMTSL3 TENM3 FAM20A FRMD3	6.36e-07	194	164	8	83863da11dfbe59b2d0a2c08db40b537c150588c
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL5A1 COL6A3 NAALAD2 ANK2 GRID2 IGDCC4 SEMA3D TENM3	6.36e-07	194	164	8	60622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Mesenchymal\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHACTR2 SSR1 TTC3 YWHAE CSDE1 GNAS MUSK PROS1	6.61e-07	195	164	8	4d63e0dca30ae57960459d2fbcba09122273e37b
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Mesenchymal-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHACTR2 SSR1 TTC3 YWHAE CSDE1 GNAS MUSK PROS1	6.61e-07	195	164	8	661af601a3561fe3aacf2444ad7b8927fa88b48a
ToppCell	facs-Lung-nan\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL5A1 NID2 COL6A3 ISM1 GAS6 FBXL3 SEMA3D PROS1	6.87e-07	196	164	8	b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCell	facs-Lung-nan-3m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL5A1 NID2 COL6A3 ISM1 GAS6 FBXL3 SEMA3D PROS1	6.87e-07	196	164	8	787c6cd92035e0b1108c2c086c42a229016e476b
ToppCell	severe_influenza-Non-classical_Monocyte\|World / disease group, cell group and cell class (v2)	SYT17 CDH23 UNC119 FBP1 RNPEP FGR FAM20A HCK	7.41e-07	198	164	8	790ee20abc9666b8095675b0d445c0914ee70ea3
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CHIT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRPM2 AGPAT4 NCF4 RENBP FAM20C SH3PXD2B FGR HCK	7.41e-07	198	164	8	0b41b3d6c2db795320e8b65d40d85fb8b618cc34
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	NID2 COL6A3 ANK2 TSPYL2 IGDCC4 TENM3 MMP14 FRMD3	7.70e-07	199	164	8	8b86c69aaf60feff53aa782559cfece7342a23de
ToppCell	droplet-Kidney-nan-24m-Myeloid-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AGPAT4 NCF4 UNC119 FGR HCK MUSK FRMD3	2.92e-06	167	164	7	2ee1660be117e20f24557522345572d11cbee813
ToppCell	P07-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	NID2 GAL3ST1 GRID2 AATK TENM3 PHOX2B FRMD3	3.55e-06	172	164	7	8d6a2a0d5f63b09a5a304a77e600a647f87e9de4
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 COL6A3 NAALAD2 CDH23 ADAMTSL3 SLC7A14 MUSK	3.98e-06	175	164	7	795a6564d5a75ffd35d39f5274b9e8d28708bbc8
ToppCell	(2)_5-FU-(4)_COL2.3+_osteoblasts\|(2)_5-FU / Stress and Cell class	COL5A1 AGPAT4 IGDCC4 FAM20C SH3PXD2B MMP14 PLOD2	4.96e-06	181	164	7	56ae86072858c156681507aecd1bc6cb0a3372d2
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	COL5A1 COL6A3 ANK2 TRO TM7SF3 TENM3 CACNA1G	5.15e-06	182	164	7	812dac35b9aa05be48258082e007f6c00e7b4dd8
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP2_(1)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	KIF13B GAL3ST1 GRID2 ADGRV1 AFAP1L2 PHOX2B FRMD3	5.15e-06	182	164	7	f7f9be9c7ef8da9864d6aefe20043b26e1bb8697
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_SCP_(0)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	KIF13B GAL3ST1 GRID2 PCDH17 AFAP1L2 PHOX2B FRMD3	5.33e-06	183	164	7	f517215ff45dec914af52dfdbc4579c19654c3aa
ToppCell	(2)_5-FU-(4)_COL2.3+_osteoblasts\|World / Stress and Cell class	COL5A1 AGPAT4 IGDCC4 FAM20C SH3PXD2B MMP14 PLOD2	5.53e-06	184	164	7	684d05340a3dfb8aa08b881516a37f9627a10448
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GAL3ST1 TRPM2 GAS6 FAM20C SH3PXD2B MMP14 FAM20A	5.73e-06	185	164	7	29d7ddcb9a2e45f76cd5611f7c52b6df689effd3
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GAL3ST1 TRPM2 GAS6 FAM20C SH3PXD2B MMP14 FAM20A	5.73e-06	185	164	7	780bdb63ef913a09930063286011c9108381d3a9
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	GAL3ST1 TRPM2 GAS6 FAM20C SH3PXD2B MMP14 FAM20A	5.73e-06	185	164	7	274b8acccdfe434d14af4cb32fb615c06ec98435
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GAL3ST1 TRPM2 GAS6 FAM20C SH3PXD2B MMP14 FAM20A	5.73e-06	185	164	7	b640d9ed6a1e6aa595053065bb992efc0402353e
ToppCell	Cerebellum-Neuronal\|Cerebellum / BrainAtlas - Mouse McCarroll V32	TRO TRPM2 TTC3 ZRSR2P1 TMEM145 KCNS2 CDH12	6.15e-06	187	164	7	61b9d6eb131a674598aa8409d7fa909c8765442d
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TNFAIP8L3 GAS6 LAMA5 GRID2 PKHD1L1 SEMA3D CDH20	6.15e-06	187	164	7	8e8f1f2a78ac5f13a414fd448af7d7ff1ea86f0f
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	COL5A1 COL6A3 GRID2 ADAMTSL3 TENM3 PGAP1 MUSK	6.15e-06	187	164	7	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 NID2 COL6A3 NAALAD2 CDH23 GRID2 ADAMTSL3	6.36e-06	188	164	7	ce85a56ac27a6432421dde93a1bafa8b943244b9
ToppCell	Control-Fibroblasts-Adventitial_FB\|Control / group, cell type (main and fine annotations)	COL5A1 COL6A3 ANK2 ADAMTSL3 SEMA3D SH3PXD2B NFATC2	6.36e-06	188	164	7	706a26c372add839d947749f0521a0e1f5c9b0ec
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL5A1 COL6A3 ANK2 SEMA3D MMP14 FAM20A FRMD3	6.59e-06	189	164	7	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D175\|Adult / Lineage, Cell type, age group and donor	COL5A1 NID2 COL6A3 ANK2 ISM1 ADAMTSL3 KIRREL1	6.82e-06	190	164	7	7dcca3469f3a3b70db0420cb94f7765f39492f06
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 NID2 COL6A3 NAALAD2 CDH23 GRID2 ADAMTSL3	6.82e-06	190	164	7	efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A3 ANK2 GRID2 IGDCC4 TENM3 FAM20A FRMD3	6.82e-06	190	164	7	45df8fee00f8949937863159d7aa042e72748d9b
ToppCell	facs-Lung-3m-Endothelial-lymphatic_endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NID2 ANK2 YES1 PKHD1L1 KCTD17 SEMA3D PROS1	6.82e-06	190	164	7	a1514d2186eb4fe569971ab22dc0c17d353fb94a
ToppCell	facs-Lung-3m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NID2 ANK2 YES1 PKHD1L1 KCTD17 SEMA3D PROS1	6.82e-06	190	164	7	0bb954a94317cfc742b9b6221bb80f8baa6d3ff1
ToppCell	facs-Lung-3m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NID2 ANK2 YES1 PKHD1L1 KCTD17 SEMA3D PROS1	6.82e-06	190	164	7	26e2237f65cb43723c5da853831b40df2982d6e4
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF13B MGAM SPATA6L SYT17 RAB11FIP2 TENM3 FAM20A	7.06e-06	191	164	7	3e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_macrophage\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TRPM2 GAS6 NCF4 RENBP FAM20A HCK PARP15	7.06e-06	191	164	7	bce138f067b8962ecef1ddec6511a3f142d81d78
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SART3 APOBEC3D SHQ1 N4BP2 VPS41 ANKIB1 PARP15	7.06e-06	191	164	7	39ef8e1d7cc3ebb11717e8a55501515e3b72b177
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL5A1 COL6A3 ANK2 ADAMTSL3 TENM3 PGAP1 MUSK	7.06e-06	191	164	7	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL5A1 COL6A3 ANK2 ADAMTSL3 TENM3 PGAP1 MUSK	7.30e-06	192	164	7	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL5A1 NID2 COL6A3 ANK2 ADAMTSL3 IGDCC4 SEMA3D	7.30e-06	192	164	7	e0f4e4470a71bfa81d9dcd8594e5f82aafc24f81
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage1_(2)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TRPM2 GAS6 NCF4 RENBP FAM20A HCK PARP15	7.30e-06	192	164	7	4e3deefd30adb7bf1eba294610eed3d077aa9418
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL5A1 COL6A3 ANK2 IGDCC4 SEMA3D TENM3 FAM20A	7.30e-06	192	164	7	deeecd26972241846b4cb998edf0c7a87ff0c4df
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EPHB6 PHACTR2 GRID2 ADAMTSL3 TENM3 FAM20A FRMD3	7.55e-06	193	164	7	3ed46f5a7419ec4eddbd0df0d9b5f53aa486198b
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PRTG PHACTR2 GRID2 ADAMTSL3 TENM3 FAM20A FRMD3	7.55e-06	193	164	7	e74fdc8718fe0933e1f4dd3fe37e2134983b99b6
ToppCell	Control-Fibroblasts-Intermediate_pathological_FB\|Control / group, cell type (main and fine annotations)	COL5A1 COL6A3 ANK2 SH3PXD2B TENM3 MMP14 MUSK	7.81e-06	194	164	7	03a269f75a481ea54aea8e6444605db8d6df493d
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	COL5A1 NID2 COL6A3 NAALAD2 SEMA3D MAST4 OSTF1	7.81e-06	194	164	7	99577a5a631e607b5abe7a1b0d8d6a5eabe50196
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF13B MGAM SPATA6L RAB11FIP2 FAM20C TENM3 FAM20A	7.81e-06	194	164	7	69bff17df4a760ccf081cf52ff04af02c14f448d
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PRTG PHACTR2 GRID2 ADAMTSL3 TENM3 FAM20A FRMD3	7.81e-06	194	164	7	1bcb3fafd498614f7bac2b1c9b7de56e39110f65
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL5A1 COL6A3 ANK2 GRID2 IGDCC4 TENM3 FRMD3	7.81e-06	194	164	7	89b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell	-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	COL5A1 COL6A3 ISM1 IGDCC4 SEMA3D NFATC2 CD226	8.08e-06	195	164	7	e5b0afbea85575851cf9eb50a9ac42c67bbf3d7c
ToppCell	facs-Thymus-Thymus_Epithelium\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 ANK2 GAS6 ADAMTSL3 TENM3 LRP2 MMP14	8.35e-06	196	164	7	6bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCell	facs-Thymus-Thymus_Epithelium-18m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 ANK2 GAS6 ADAMTSL3 TENM3 LRP2 MMP14	8.35e-06	196	164	7	c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NDNF NID2 COL6A3 TBX3 GAS6 ADAMTSL3 AFAP1L2	8.35e-06	196	164	7	9d18381d7aaa063094a5df769a04c73350471525
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NDNF NID2 COL6A3 TBX3 GAS6 ADAMTSL3 AFAP1L2	8.35e-06	196	164	7	a52cb512c6173be92aa9c4d96e2abbc32f45478d
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NDNF NID2 COL6A3 TBX3 GAS6 ADAMTSL3 AFAP1L2	8.35e-06	196	164	7	afddacc0fb8b9c73dad5333137deb471a6ebdc06
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NDNF COL5A1 COL6A3 TBX3 LAMA5 PCDH17 MMP14	8.63e-06	197	164	7	467e7cbf511d3bcc701923603032aaf0bba2736d
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NCF4 RENBP ACSL1 FGR FAM20A HCK SEZ6L	8.63e-06	197	164	7	555ea43eccc3eb22be230c27e13d8b3b64c2a61f
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	NDNF COL6A3 NAALAD2 SEMA3D MAST4 OSTF1 CDH12	8.63e-06	197	164	7	11a4c417f035e554431a8f03be13b5eefa3530c0
ToppCell	tumor_Lung-Fibroblasts-COL14A1+_matrix_FBs\|tumor_Lung / Location, Cell class and cell subclass	COL5A1 COL6A3 ANK2 ISM1 GAS6 IGDCC4 MMP14	8.92e-06	198	164	7	74f2c7ef702b25a5b99e56121229e678ed992524
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	NDNF COL5A1 PRTG IGDCC4 TENM3 KIRREL1 PLOD2	9.22e-06	199	164	7	d65ee89d5c7e8ed693d58e6a6de09565840e11c5
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DSC2 NCF4 RENBP ACSL1 FBP1 FGR HCK	9.22e-06	199	164	7	7648860058eec66019b574ad840d6f5cfa4476d9
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KIF13B TBX3 ADGRV1 PCDH17 CFAP20 PHOX2B FRMD3	9.22e-06	199	164	7	f1d5808ccb1d5d4e2d34f864e705e2484000e88f
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DSC2 ACSL1 FAM20C SH3PXD2B FBP1 FGR HCK	9.22e-06	199	164	7	80ed217d28ba1c07facd0e103c25a02658dd848d
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DSC2 NCF4 RENBP ACSL1 FBP1 FGR HCK	9.22e-06	199	164	7	91c72e06a7416671977430211c57938e39e8195e
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_CHIT1\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TRPM2 NCF4 RENBP ACSL1 FBP1 FGR HCK	9.22e-06	199	164	7	368e2bafae00ce8e9c6ea480f81b78f96b680acd
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	NDNF COL5A1 PRTG IGDCC4 TENM3 KIRREL1 PLOD2	9.22e-06	199	164	7	bf138cc692df727e087d140c014149ee5da00d9d
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PRTG GRID2 ADAMTSL3 TENM3 FAM20A MUSK FRMD3	9.53e-06	200	164	7	a9cdddc4e985dae59521e557479c24fcc2ac727d
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-STK32A-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	EPHB6 PHACTR2 GRID2 RENBP ADAMTSL3 FAM20A FRMD3	9.53e-06	200	164	7	6a44439e4a7ce3627271375b04cfcfb9467218f4
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL5A1 COL6A3 ANK2 ISM1 GRID2 ADAMTSL3 TENM3	9.53e-06	200	164	7	a4ec0e80f5422b91b85264a9bb74568dd577e285
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6--L3-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PRTG GRID2 ADAMTSL3 TENM3 FAM20A MUSK FRMD3	9.53e-06	200	164	7	33b9199e0dfc267e2cea20b82d1c167f8adcc635
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	COL5A1 COL6A3 FAM20C KIRREL1 MMP14 FAM20A PLOD2	9.53e-06	200	164	7	ad3fb8ef0be45032369d1325024787fbe1dfb8d6
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Interneuron\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	COL5A1 ABCC1 DENND4A ERAP1 AFAP1L2 AGL PROS1	9.53e-06	200	164	7	a6500d0d2e8bcac92381ab771dbdee66b0e1d48e
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-STK32A\|Neuronal / cells hierarchy compared to all cells using T-Statistic	EPHB6 PHACTR2 GRID2 RENBP ADAMTSL3 FAM20A FRMD3	9.53e-06	200	164	7	8d51b4f7b7002ee51401ebe5eaca1e8f04bfadd5
ToppCell	Caecum-(6)_Macrophage\|Caecum / shred on region, Cell_type, and subtype	DSC2 FAM20C SH3PXD2B FGR MMP14 FAM20A HCK	9.53e-06	200	164	7	2ce3930645c3daf6be578f7881e57a58df61e75c
ToppCell	Caecum-Macrophage\|Caecum / Region, Cell class and subclass	DSC2 FAM20C SH3PXD2B FGR MMP14 FAM20A HCK	9.53e-06	200	164	7	d83209559187a4419df2508ecc5eb9f7d72fced3
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PRTG GRID2 ADAMTSL3 TENM3 FAM20A MUSK FRMD3	9.53e-06	200	164	7	9719fabddc34051949468a7520289e3c750de4f8
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-STK32A--L4-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	EPHB6 PHACTR2 GRID2 RENBP ADAMTSL3 FAM20A FRMD3	9.53e-06	200	164	7	cb1f4b0d66da5b0466ff17b29e7034d451d93e4f
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL5A1 COL6A3 ANK2 ADAMTSL3 IGDCC4 SEMA3D SH3PXD2B	9.53e-06	200	164	7	74e74123ea7bf38d337a3a0248a6a51437c6ab42
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	COL5A1 COL6A3 NAALAD2 ANK2 SEMA3D MMP14 FRMD3	9.53e-06	200	164	7	bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MGAM TRPM2 MCMDC2 FAM20C FGR HCK	1.64e-05	145	164	6	ab0e254a8d01021619853a6c175f620ccef217d8
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic-Neutrophil\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MGAM TRPM2 MCMDC2 FAM20C FGR HCK	1.64e-05	145	164	6	2beb4ea3838796c580076ab7769de877a3a0552c
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL5A1 KCNV2 ADAMTSL3 SEC14L3 SEZ6L FRMD3	1.84e-05	148	164	6	dfd3f2c4b884ea9e23831a242a89ac985b409640
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B1\|367C / Donor, Lineage, Cell class and subclass (all cells)	SART3 APOBEC3D SHQ1 NFATC2 N4BP2 PARP15	2.96e-05	161	164	6	f470b662566131dfe69a2fd01186ac8491196396
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-4\|TCGA-Lung / Sample_Type by Project: Shred V9	COL5A1 NID2 IGDCC4 SH3PXD2B KIRREL1 MMP14	3.75e-05	168	164	6	aefea14b8b1c1b6a05f827effd22ba15274fddc9
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL5A1 COL6A3 CATSPER3 SEMA3D TENM3 MMP14	3.88e-05	169	164	6	031465190cd3623a25ef2b868daab8d932c8ff08
ToppCell	ileum\|World / shred on tissue and cell subclass	MGAM TBX3 DSC2 APOB FBP1 ERAP2	4.01e-05	170	164	6	9f1211bd4287620e19a59f21e6ecdca3e42e0260
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_monocytic-non-classical_monocyte\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DSC2 ACSL1 SH3PXD2B FGR FAM20A HCK	4.28e-05	172	164	6	968d18ab8c3cdeb7936a2aa721a7f41525763863
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MGAM TRPM2 RENBP ACSL1 FGR HCK	4.28e-05	172	164	6	72fbfa890995e47048b47199c170cc7dcd7661f8
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MGAM TRPM2 RENBP ACSL1 FGR HCK	4.28e-05	172	164	6	2ca6f0d1181aabe0d0e3e8f2e193f08dbda42dea
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 NAALAD2 TRPM2 ISM1 OSTF1 MMP14	4.42e-05	173	164	6	ab6d3507301038f944ad59ccd848b5e6eeb76d04
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADGRV1 PCDH17 AATK PGAP1 ETAA1 PHOX2B	4.42e-05	173	164	6	23e50492bc673aff9df95d97f0b9be4ce57cbf01
Disease	Colorectal Carcinoma	EPHB6 ABCC1 ANK2 GRID2 APOB ADAMTSL3 PGM1 CD226 BUB1B ETAA1 LRP2 DLG3 GNAS PROS1	2.33e-05	702	156	14	C0009402
Disease	platelet component distribution width	LAMA5 JMY KCTD17 CRKL SEC14L3 ACSL3 SEPTIN8 HABP4 IGF1R AFAP1L2 CD226 DLG3 GNAS MUSK	5.12e-05	755	156	14	EFO_0007984
Disease	kidney disease (implicated_via_orthology)	YES1 KIRREL1 FGR HCK	6.54e-05	41	156	4	DOID:557 (implicated_via_orthology)
Disease	gastrinoma (is_marker_for)	MET IGF1R	8.30e-05	3	156	2	DOID:5577 (is_marker_for)
Disease	proprotein convertase subtilisin/kexin type 9 measurement	PHACTR2 APOB MUSK	2.07e-04	22	156	3	EFO_0009312
Disease	ceramide measurement	GAL3ST1 ISM1 APOB MDN1 SLC13A1 MUSK FRMD3	2.65e-04	235	156	7	EFO_0010222
Disease	immunoglobulin superfamily DCC subclass member 4 measurement	DENND4A IGDCC4	2.75e-04	5	156	2	EFO_0801690
Disease	carcinoma (implicated_via_orthology)	YES1 DLG3 FGR HCK	3.73e-04	64	156	4	DOID:305 (implicated_via_orthology)
Disease	body weight	NDNF NID2 MGAM AARS1 GRID2 CHD8 ADGRV1 ADAMTSL3 ACSL3 SH3PXD2B IGF1R AATK MAST4 NFATC2 FARS2 GNAS FGR	3.85e-04	1261	156	17	EFO_0004338
Disease	Glycogen Storage Disease	PGM1 FBP1 AGL	3.86e-04	27	156	3	C0017919
Disease	ocular sarcoidosis	IGF1R USP32 LRP2 TMX3 CDH12	3.87e-04	116	156	5	EFO_0010723
Disease	Cone-Rod Dystrophy 2	UNC119 ATF6 GUCY2D	4.79e-04	29	156	3	C3489532
Disease	serum metabolite measurement	UNC119B ABCC1 LAMB4 NAALAD2 MLEC ERAP1 RAB11FIP2 APOB MTA1 TENM3 ERAP2 VPS41 FAM20A MUSK	5.15e-04	945	156	14	EFO_0005653
Disease	colorectal cancer (implicated_via_orthology)	YES1 FGR HCK	5.30e-04	30	156	3	DOID:9256 (implicated_via_orthology)
Disease	endoplasmic reticulum aminopeptidase 1 measurement	ERAP1 ERAP2	5.73e-04	7	156	2	EFO_0008119
Disease	Ovarian Mucinous Adenocarcinoma	EPHB6 AATK HCK	5.84e-04	31	156	3	C1335167
Disease	fear of minor pain measurement	AGPAT4 MAB21L3 HCK	5.84e-04	31	156	3	EFO_0008340
Disease	intestinal cancer (implicated_via_orthology)	YES1 FGR HCK	6.42e-04	32	156	3	DOID:10155 (implicated_via_orthology)
Disease	hyperuricemia	IGF1R LRP2 GNAS	7.04e-04	33	156	3	EFO_0009104
Disease	neonatal abstinence syndrome	GAL3ST1 SNX13 FAM20A CDH12	7.54e-04	77	156	4	EFO_0005799
Disease	butyrylcarnitine (C4) measurement	UNC119B MLEC	7.62e-04	8	156	2	EFO_0800201
Disease	severe pre-eclampsia (is_marker_for)	ERAP1 ERAP2	7.62e-04	8	156	2	DOID:13129 (is_marker_for)
Disease	Growth Disorders	SH3PXD2B IGF1R BUB1B	9.11e-04	36	156	3	C0018273
Disease	corticobasal degeneration disorder	KIF13B SOS1	9.76e-04	9	156	2	MONDO_0022308
Disease	non-syndromic X-linked intellectual disability (implicated_via_orthology)	ACSL3 DLG3	9.76e-04	9	156	2	DOID:0050776 (implicated_via_orthology)
Disease	mean platelet volume	SPATA6L ERAP1 TM7SF3 YWHAE CRKL SNX13 ACSL1 ACSL3 HABP4 MAST4 CD226 DLG3 GNAS MUSK	1.08e-03	1020	156	14	EFO_0004584
Disease	Parkinson Disease	TRPM2 IGF1R MTA1 FBP1	1.09e-03	85	156	4	C0030567
Disease	neuroblastoma (is_implicated_in)	IGF1R PHOX2B	1.22e-03	10	156	2	DOID:769 (is_implicated_in)
Disease	sleep duration, low density lipoprotein cholesterol measurement	APOB SNX13 NPC1L1 MUSK	1.41e-03	91	156	4	EFO_0004611, EFO_0005271
Disease	very low density lipoprotein cholesterol measurement, phospholipid measurement	GAS6 AGPAT4 APOB NPC1L1 TGM7 MUSK	1.41e-03	229	156	6	EFO_0004639, EFO_0008317
Disease	Crohn's disease of large bowel	NCF4 ERAP2 PHOX2B	1.64e-03	44	156	3	C0156147
Disease	IIeocolitis	NCF4 ERAP2 PHOX2B	1.64e-03	44	156	3	C0949272
Disease	Crohn's disease of the ileum	NCF4 ERAP2 PHOX2B	1.64e-03	44	156	3	C0267380
Disease	Regional enteritis	NCF4 ERAP2 PHOX2B	1.64e-03	44	156	3	C0678202
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, lipid measurement	GAS6 AGPAT4 APOB MUSK	1.65e-03	95	156	4	EFO_0004529, EFO_0008317, EFO_0008596
Disease	Thromboembolism	GAS6 PROS1	1.77e-03	12	156	2	C0040038
Disease	Neuroblastoma	MET GNAS PHOX2B	1.98e-03	47	156	3	C0027819
Disease	triglyceride measurement, alcohol consumption measurement	GAS6 APOB SNX13 MUSK	2.06e-03	101	156	4	EFO_0004530, EFO_0007878
Disease	Retinitis Pigmentosa	SLC7A14 UNC119 ATF6 GUCY2D	2.29e-03	104	156	4	C0035334
Disease	Crohn Disease	NCF4 ERAP2 PHOX2B	2.37e-03	50	156	3	C0010346
Disease	lysophosphatidylcholine 22:5 measurement	NFATC2 MUSK	2.42e-03	14	156	2	EFO_0021462
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement	GAS6 AGPAT4 APOB MUSK	2.46e-03	106	156	4	EFO_0008317, EFO_0008596
Disease	Schizophrenia	ADAMTSL3 YWHAE PCDH17 MET SEMA3D FBP1 TRMT2A KAT8 LRP2 DLG3 GNAS PHOX2B	2.64e-03	883	156	12	C0036341
Disease	Intellectual Disability	CHD8 FBXL3 CSDE1 KAT8 LRP2 CACNA1G GNAS MED13	2.69e-03	447	156	8	C3714756
Disease	delta-6 desaturase measurement	MAST4 MUSK	2.79e-03	15	156	2	EFO_0007765
Disease	level of Phosphatidylcholine (16:0_16:0) in blood serum	SNX13 MUSK	2.79e-03	15	156	2	OBA_2045067
Disease	cholesteryl ester measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	GAS6 AGPAT4 APOB MUSK	2.81e-03	110	156	4	EFO_0008317, EFO_0008596, EFO_0010351
Disease	Ciliopathies	CDH23 ADGRV1 CIBAR1 GUCY2D	2.81e-03	110	156	4	C4277690
Disease	free cholesterol measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	GAS6 AGPAT4 APOB MUSK	2.81e-03	110	156	4	EFO_0008317, EFO_0008591, EFO_0008596
Disease	chylomicron measurement, total cholesterol measurement, very low density lipoprotein cholesterol measurement	GAS6 AGPAT4 APOB MUSK	2.81e-03	110	156	4	EFO_0004574, EFO_0008317, EFO_0008596
Disease	cancer (implicated_via_orthology)	TBX3 YES1 TPK1 DLG3 FGR HCK	3.10e-03	268	156	6	DOID:162 (implicated_via_orthology)
Disease	Alpha ketoglutarate measurement	KCNV2 TENM3	3.17e-03	16	156	2	EFO_0010457
Disease	antihyperlipidemic drug use measurement	GAS6 APOB NPC1L1 MUSK	3.30e-03	115	156	4	EFO_0803367
Disease	Glycogen storage disease	PGM1 AGL	3.59e-03	17	156	2	cv:C0017919
Disease	spine bone size	ADAMTSL3 MUSK	4.02e-03	18	156	2	EFO_0004508
Disease	triglycerides in medium LDL measurement	GAS6 APOB MUSK	4.36e-03	62	156	3	EFO_0022322
Disease	lysophosphatidylcholine measurement	MGAM COL6A3 MUSK	4.36e-03	62	156	3	EFO_0010224
Disease	cerebral infarction (is_marker_for)	APOB SOS1	4.48e-03	19	156	2	DOID:3526 (is_marker_for)
Disease	anorectal malformation	TRPM2 GAS6	4.48e-03	19	156	2	MONDO_0019938
Disease	sodium-coupled monocarboxylate transporter 1 measurement	APOB MUSK	4.48e-03	19	156	2	EFO_0802076
Disease	Malignant neoplasm of breast	ABCC1 NID2 TBX3 ANK2 TTC3 APOBEC3B NLRP14 IGF1R CDH20 TRMT2A N4BP2 MMP14 CTU1	4.73e-03	1074	156	13	C0006142
Disease	coagulation factor V measurement	MAST4 MUSK	4.96e-03	20	156	2	EFO_0008087
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Positive	IGF1R FAM20A PLOD2 PROS1	5.24e-03	131	156	4	C4704862
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Negative	IGF1R FAM20A PLOD2 PROS1	5.24e-03	131	156	4	C4552091
Disease	Juvenile arthritis	IGF1R FAM20A PLOD2 PROS1	5.24e-03	131	156	4	C3495559
Disease	Juvenile psoriatic arthritis	IGF1R FAM20A PLOD2 PROS1	5.24e-03	131	156	4	C3714758

Protein segments in the cluster

Peptide	Gene	Start	Entry
AFEYEIRFYTGNDPL	BUB1B	61	O60566
NFSVFYYEILNSPDR	YWHAE	176	P62258
FYRVVSTFGVEYDPD	CHD8	1806	Q9HCK8
TFYDNFENEPILYGR	APOBEC3D	16	Q96AK3
LADDFLDFYLEYFPE	RNPEP	451	Q9H4A4
LPFIDIYFSTLDYQD	CATSPER3	346	Q86XQ3
QDYVQYRSFFDEAPA	CXorf58	181	Q96LI9
TFYDNFENEPILYGR	APOBEC3B	16	Q9UH17
LDSDEPLVYFYDDVT	ACSL1	76	P33121
PAELLFYIQDSDDVY	ADGRV1	501	Q8WXG9
DPEEFTYDYVDADRV	AFAP1L2	451	Q8N4X5
GFASPEEYAEFQYRR	ANKIB1	756	Q9P2G1
ERNGEVFYLTYTPED	CSDE1	131	O75534
YASPRSYQDFFEAIR	ATF6	546	P18850
DLEYFQRRYFTPAEV	CYB5D1	11	Q6P9G0
AIPLDYETVDRYDFD	CDH23	416	Q9H251
ENDNYPIFTEETYTF	DSC2	236	Q02487
RDLEPNTDYEFYVVA	IGDCC4	491	Q8TDY8
YRFNEELRAVDSEYP	MMP14	436	P50281
FIVGIDSRYFDLYDP	DENND4A	466	Q7Z401
GRNFFTRYDYEEVEA	PGM1	421	P36871
NALDEYPAEDFTEVY	RBM48	76	Q5RL73
ENYDNFYTVVTDRPL	PCDH17	416	O14917
PEESSLEYQQEYFVT	ANK2	3761	Q01484
FEVDQSVFEIPESYY	ANKRD13A	456	Q8IZ07
SILFDYEYLNPNEEE	NFATC2	31	Q13469
QVAEYTFRQFRDPEY	RENBP	351	P51606
VVFFDNQAYPEYLIT	PARP15	661	Q460N3
FLGRYEPFSEIERYD	KLHL34	531	Q8N239
VEFPYQYDFSRTLDE	KIAA0100	826	Q14667
QFRKRLSEEYTFYPD	MDN1	3381	Q9NU22
YEDYFPEIFREASVC	MAGEA11	256	P43364
NAVFPFELYNEEYLE	MCMDC2	636	Q4G0Z9
SQVLFTETDDPEEYY	JMY	306	Q8N9B5
ERPTFEYLQSFLEDY	FGR	501	P09769
VEPEYFEQVTLYFSD	GUCY2D	871	Q02846
QYPAAFEFSETYLAV	MTMR10	476	Q9NXD2
TERYNEETFGYEVPI	MLEC	101	Q14165
LYFDVEPFVFYILTE	KAT8	276	Q9H7Z6
YFSDRLYSEDELPAE	CFAP20	166	Q9Y6A4
EDLFQDAYYQSPETR	ASMTL	411	O95671
SQVELYRAYVAFPDF	MGAM	1371	O43451
DSQVELYRAYVAFPD	MGAM	2266	O43451
AYFFDNPRRYDSDDD	GPR137C	346	Q8N3F9
SDTYFDDERRQLFYT	FSIP2	4601	Q5CZC0
YRPYETERQADFTAE	HABP4	151	Q5JVS0
EPGFREVSFYYSEEN	IGF1R	1271	P08069
DRYTEPFAIFQLPYE	ITGAE	806	P38570
AVTLLEFYEDYFSIP	ERAP1	286	Q9NZ08
RYGNVPFEYEDSETV	GPATCH3	231	Q96I76
FYDSEYDIRGIQEFL	GRID2	171	O43424
YRSPGEDQLFSEFYV	NLRP1	1311	Q9C000
DYDDVQREFYFDRNP	KCNS2	61	Q9ULS6
DEDVRIFFYQSPYDS	NCF4	126	Q15080
VSDLKPDTQYYFDVF	NDNF	301	Q8TB73
SFLYYTDEQYEVIER	LRP2	1971	P98164
FNEYVEVTDSPDYDR	PHACTR2	576	O75167
ENVYSFGYLREEPLD	LAMA5	1381	O15230
AEDNLEYVRTLYDFP	CRKL	121	P46109
EYVRTLYDFPGNDAE	CRKL	126	P46109
YTEVQFRPYRTDDFI	CYHR1	231	Q6ZMK1
DETGAYLIDRDPTYF	KCTD17	71	Q8N5Z5
YLSPQELEDVFYQYD	MLKL	376	Q8NB16
DIRFQAVPYSDTYNE	MAB21L3	46	Q8N8X9
DYYFSVDADVVLTNP	PLOD2	386	O00469
TYDRELIDAEYRFSP	ETAA1	451	Q9NY74
DDLEPASNYTFYIVA	PRTG	481	Q2VWP7
QDFPRETQYVDYDFP	NID2	86	Q14112
ETQYVDYDFPTDFPA	NID2	91	Q14112
AFEVFPYTITNVFYE	NPC1L1	1116	Q9UHC9
YARDFDPAVTEYIQR	FBP1	216	P09467
RYDFEDDEESTIYAP	FBXO38	1121	Q6PIJ6
DYPTFFARSLVQDYR	GAL3ST1	116	Q99999
FSIDRDYFQEIGTYD	GALNT1	296	Q10472
EIRQTPEFEQFHYEY	FRMD3	561	A2A2Y4
DEINTIFSDYIPYVF	APOB	4331	P04114
RPTFEYIQSVLDDFY	HCK	501	P08631
EDISQYGIARFFTEY	CSTPP1	36	Q9H6J7
EDLEVFRNSLYAPDY	CIBAR1	216	A1XBS5
ERYYQTENEDESPFI	CACNA1G	256	O43497
YEEEFDPFFRYEIPA	FBXL3	296	Q9UKT7
REQETPPDFFYFSDY	FAM20C	291	Q8IXL6
FFVLEEYTGTDPLYV	CDH20	66	Q9HBT6
REVFENDPETDYFYP	GAS6	76	Q14393
DYFSEECVYAPEAFR	CTU1	231	Q7Z7A3
VAQYADTVRPEFYFN	COL6A3	486	P12111
EETIRNLDENYYDPY	COL5A1	406	P20908
IVAQYRPEEYSRFES	DLG3	461	Q92796
FINYEPETLQYEFDV	MCF2	376	P10911
LEFDPEEFYYLLEAA	MAST4	486	O15021
RYDEYGDEQVTFTAP	DNAJC18	141	Q9H819
NYYRDFEADITPEEL	DNAJC18	161	Q9H819
ATYPELQFDDYFLNV	ERAP2	406	Q6P179
RYETNVDYSFFTEPV	KIRREL1	271	Q96J84
APLNFYLYEAEEATT	LAMB4	546	A4D0S4
FFVLEEYVGSEPQYV	CDH12	61	P55289
EPVFSFDYAVYVTIA	CLDN12	166	P56749
DTREDIYVNYPTFSR	CD226	316	Q15762
VEDYFTLYADVPLND	GFM1	681	Q96RP9
FYPDTSFQEDEDYRD	RPRD2	821	Q5VT52
EAPRLAEYQAYIDFE	SART3	306	Q15020
TNLIFAEYFNTRYPD	SLC13A1	261	Q9BZW2
YQEFFGLLEENYPET	SEC14L3	171	Q9UDX4
YPTEVAYSTADIFDR	ISM1	326	B1AKI9
TYFLESEPFLYEIFR	BVES	236	Q8NE79
YTFEPRTPDELYFEE	OSTF1	21	Q92882
AVYSNADIYLFDDPL	ABCC1	781	P33527
RSYFKRADPFYDEQE	KIF13B	781	Q9NQT8
DQSYIDVLPEFRDSY	MET	231	P08581
FSTEFRAQPLAYYEA	RPUSD2	166	Q8IZ73
DERFYPSFRQNALYV	SNX13	496	Q9Y5W8
AYYEENTRDFLFPEP	SPATA6L	81	Q8N4H0
AFQEFIRSTPYSAYD	TRMT2A	291	Q8IZ69
EFDNPIYETGETREY	SEZ6L	1006	Q9BYH1
IVESLDASFRYPQDY	SSR1	116	P43307
YLFPETEFIAVTAYQ	TBX3	271	O15119
FEERYTFEIPFLEAQ	SYT17	256	Q9BSW7
PYRDSAYFSDLEAEA	AATK	991	Q6ZMQ8
ENATGFSYESLFREY	MITD1	96	Q8WV92
QQRDEETPVDFFYFI	FAM20A	241	Q96MK3
IEDYFPEFARYTTPE	GNAS	951	Q5JWF2
ETFTLYYRQAEEPDS	EPHB6	126	O15197
DYEEQTDEYFFDRDP	KCNV2	141	Q8TDN2
TDEYFFDRDPAVFQL	KCNV2	146	Q8TDN2
SEYDTPLYFEEDEVR	SETD3	181	Q86TU7
VPYARVSEFDVYFEG	SHQ1	21	Q6PI26
AYNESEKIYFTFPLE	PGAP1	361	Q75T13
VYIIDPFTYENTDES	MED13	1641	Q9UHV7
LEREDFFFYSLVYDP	MTA1	141	Q13330
LAEELAFDPYESYAR	SOS1	286	Q07889
EFDFRTYDSEGVILY	PROS1	326	P07225
DTYNPDDDKIYFFFR	SEMA3D	251	O95025
EKFSPEAFTEQLYRY	ALG2	396	Q9H553
LTYIPFYFFSESRQE	ACSL3	36	O95573
STYQRYDVDDPFSVE	SLC7A14	691	Q8TBB6
VYTYFFSASEEVVPE	TMX3	176	Q96JJ7
YVTEEPEIYEPNFIF	SF3B2	371	Q13435
TIVSFYEVEYTFDRN	TNFAIP8L3	206	Q5GJ75
ERPYEFSECGELFRY	ZNF749	221	O43361
PYETQSDSFYFVDDR	UNC119	211	Q13432
DAPDYYAVEDIFSEI	TSPYL2	426	Q9H2G4
SNYDTDLFVPYFEAI	AARS1	256	P49588
QEYDEYFPEIIERAS	TRO	476	Q12816
EEYYTIAEFQTTIPD	SH3PXD2B	371	A1X283
TEFLIYDPPFYTAER	TRPM2	1266	O94759
NPYETRSDSFYFVDN	UNC119B	221	A6NIH7
FSAEYEFFPEETRQI	TTC3	1131	P53804
SYRPIVDYIDAQFEN	SEPTIN8	116	Q92599
YEVASPTDQELYIFD	TENM3	1511	Q9P273
RQDYFDYESTNPFTA	RAB11FIP2	396	Q7L804
DDRYAIYFSQTGLPE	PKHD1L1	411	Q86WI1
SRYVEIVSQFETEFY	VPS41	256	P49754
EPSTREQFLQYAYDI	TRIM16	361	O95361
EQFLQYAYDITFDPD	TRIM16	366	O95361
ETYQQFLDFYEDVLP	ZRSR2P1	236	Q15695
KDAFQEEYYRTGTFP	AGPAT4	281	Q9NRZ5
YDTPFVYAEVNADEV	TGM7	391	Q96PF1
LPSENYAENDFYDLV	FARS2	371	O95363
VFAETHYPDIYTREE	PHOX2B	116	Q99453
YAFFYLRLTTDVDPD	TRIQK	66	Q629K1
EFTEYYFPDNQELPV	UHRF1BP1	511	Q6BDS2
ETYQQFLDFYEDVLP	ZRSR2	231	Q15696
PDEIDTDSAYILFYE	USP32	1551	Q8NFA0
FYRYVLEPEISFTSD	UGGT1	1036	Q9NYU2
DFDSIRPEVREYYAT	TPK1	71	Q9H3S4
IYEAEFFDPGQVLYT	TMEM145	296	Q8NBT3
DIDPNIYLEYNFFET	TM7SF3	146	Q9NS93
RPTFEYIQSFLEDYF	YES1	516	P07947
YIQSFLEDYFTATEP	YES1	521	P07947
FLEDTTGEQFLTYRY	ADAMTSL3	46	P82987
VTRYFTFPFEEIDFS	AGL	426	P35573
SEDAREEYIYQFFED	NLRP14	331	Q86W24
YETFELVEKFYDPTF	NAALAD2	546	Q9Y3Q0
PESIFYNRYTTESDV	MUSK	771	O15146
PSELSFQDFEYPDYD	N4BP2	1606	Q86UW6