Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbitter taste receptor activity

TAS2R42 TAS2R9 TAS2R7 TAS2R5 TAS2R40

6.43e-0827795GO:0033038
GeneOntologyMolecularFunctiontaste receptor activity

TAS2R42 TAS2R9 TAS2R7 TAS2R5 TAS2R40

1.86e-0733795GO:0008527
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

TAS2R42 TPRA1 TAS2R9 ADRA1A TAS2R7 TAS2R5 GPR31 PTPRN2 GPR32P1 SCN7A OR52N5 PLXNA4 TACR2 TAS2R40 OPN1SW KIR3DL2 GRM8 PLXNA1 GPR45 TMEM63A

2.03e-0713537920GO:0004888
GeneOntologyMolecularFunctionG protein-coupled receptor activity

TAS2R42 TPRA1 TAS2R9 ADRA1A TAS2R7 TAS2R5 GPR31 GPR32P1 OR52N5 TACR2 TAS2R40 OPN1SW GRM8 GPR45

8.53e-068847914GO:0004930
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC37A1 ATP13A4 ABCA5 SLC35E2A PIEZO1 SCN7A SLC6A5 AKR1C4 TTYH3 CTNS SLC35E2B SLC30A9 SLC48A1 CNGA3 SLC44A3 TMEM63A

1.26e-0511807916GO:0022857
GeneOntologyMolecularFunctionalcohol-forming very long-chain fatty acyl-CoA reductase activity

FAR2 FAR1

1.55e-052792GO:0080019
GeneOntologyMolecularFunctionalcohol-forming long-chain fatty acyl-CoA reductase activity

FAR2 FAR1

1.55e-052792GO:0102965
GeneOntologyMolecularFunctiontransporter activity

SLC37A1 ATP13A4 ABCA5 SLC35E2A PIEZO1 SCN7A SLC6A5 AKR1C4 TTYH3 CTNS SLC35E2B SLC30A9 SLC48A1 CNGA3 SLC44A3 TMEM63A

3.73e-0512897916GO:0005215
GeneOntologyMolecularFunctionosmolarity-sensing monoatomic cation channel activity

SCN7A TMEM63A

1.53e-045792GO:1990760
GeneOntologyMolecularFunctionosmosensor activity

SCN7A TMEM63A

2.29e-046792GO:0005034
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC37A1 ATP13A4 ABCA5 SLC35E2A SLC6A5 CTNS SLC35E2B SLC30A9

5.91e-04477798GO:0022804
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

FAR2 AKR1C4 FAR1

9.07e-0448793GO:0016620
GeneOntologyMolecularFunctionsemaphorin receptor activity

PLXNA4 PLXNA1

9.94e-0412792GO:0017154
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC37A1 SLC35E2A SLC6A5 CTNS SLC35E2B SLC30A9

1.13e-03296796GO:0015291
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors

FAR2 AKR1C4 FAR1

1.42e-0356793GO:0016903
GeneOntologyMolecularFunctionantiporter activity

SLC37A1 SLC35E2A SLC35E2B SLC30A9

2.20e-03138794GO:0015297
GeneOntologyMolecularFunctionmechanosensitive monoatomic ion channel activity

PIEZO1 TMEM63A

2.27e-0318792GO:0008381
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC37A1 ATP13A4 SCN7A SLC6A5 TTYH3 CTNS SLC30A9 CNGA3 TMEM63A

2.99e-03758799GO:0015318
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of bitter taste

TAS2R42 TAS2R9 TAS2R7 TAS2R5 TAS2R40

6.16e-0744775GO:0001580
GeneOntologyBiologicalProcesssensory perception of bitter taste

TAS2R42 TAS2R9 TAS2R7 TAS2R5 TAS2R40

9.60e-0748775GO:0050913
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of taste

TAS2R42 TAS2R9 TAS2R7 TAS2R5 TAS2R40

1.18e-0650775GO:0050912
GeneOntologyBiologicalProcesssensory perception of taste

TAS2R42 TAS2R9 TAS2R7 TAS2R5 TAS2R40

6.37e-0670775GO:0050909
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

GPR180 TAS2R42 TPRA1 TAS2R9 ADRA1A TAS2R7 TAS2R5 GPR31 GPR32P1 OR52N5 TACR2 AKR1C4 TAS2R40 OPN1SW GRM8 GPR45

4.70e-0513957716GO:0007186
GeneOntologyBiologicalProcesswax biosynthetic process

FAR2 FAR1

8.21e-054772GO:0010025
GeneOntologyBiologicalProcesswax metabolic process

FAR2 FAR1

8.21e-054772GO:0010166
DomainTAS2R

TAS2R42 TAS2R9 TAS2R7 TAS2R5 TAS2R40

6.85e-0826785PF05296
DomainT2R

TAS2R42 TAS2R9 TAS2R7 TAS2R5 TAS2R40

6.85e-0826785IPR007960
DomainTM4_1

TSPAN15 TSPAN8 TSPAN6 CD151

3.92e-0626784PS00421
DomainTetraspanin

TSPAN15 TSPAN8 TSPAN6 CD151

9.26e-0632784IPR000301
DomainTetraspanin_EC2

TSPAN15 TSPAN8 TSPAN6 CD151

9.26e-0632784IPR008952
DomainTetraspannin

TSPAN15 TSPAN8 TSPAN6 CD151

1.05e-0533784PF00335
DomainTetraspanin/Peripherin

TSPAN15 TSPAN8 TSPAN6 CD151

1.05e-0533784IPR018499
DomainFAR_C

FAR2 FAR1

1.72e-052782IPR033640
DomainFAR

FAR2 FAR1

1.72e-052782IPR026055
DomainMale_sterile_NAD-bd

FAR2 FAR1

1.72e-052782IPR013120
DomainNAD_binding_4

FAR2 FAR1

1.72e-052782PF07993
DomainSterile

FAR2 FAR1

1.72e-052782PF03015
DomainTetraspanin_CS

TSPAN8 TSPAN6 CD151

8.83e-0521783IPR018503
DomainPSI

MEGF8 PLXNA4 PLXNA1

3.19e-0432783PF01437
DomainPlexin_repeat

MEGF8 PLXNA4 PLXNA1

3.19e-0432783IPR002165
DomainPlexin_cytopl

PLXNA4 PLXNA1

6.08e-049782PF08337
DomainPlexin_cytoplasmic_RasGAP_dom

PLXNA4 PLXNA1

6.08e-049782IPR013548
DomainPlexin

PLXNA4 PLXNA1

6.08e-049782IPR031148
DomainSugar_P_trans_dom

SLC35E2A SLC35E2B

7.58e-0410782IPR004853
DomainTPT

SLC35E2A SLC35E2B

7.58e-0410782PF03151
DomainPSI

MEGF8 PLXNA4 PLXNA1

8.20e-0444783IPR016201
DomainPSI

MEGF8 PLXNA4 PLXNA1

9.35e-0446783SM00423
DomainEamA_dom

SLC35E2B SLC35F4

1.52e-0314782IPR000620
DomainEamA

SLC35E2B SLC35F4

1.52e-0314782PF00892
DomainGPCR_Rhodpsn_7TM

TAS2R42 TAS2R9 ADRA1A TAS2R7 GPR31 OR52N5 TACR2 OPN1SW GPR45

1.87e-03670789IPR017452
DomainG_PROTEIN_RECEP_F1_2

TAS2R42 TAS2R9 ADRA1A TAS2R7 GPR31 OR52N5 TACR2 OPN1SW GPR45

2.30e-03691789PS50262
DomainGPCR_Rhodpsn

TAS2R42 TAS2R9 ADRA1A TAS2R7 GPR31 OR52N5 TACR2 OPN1SW GPR45

2.33e-03692789IPR000276
DomainUDPGT

UGT2B28 UGT2B11

3.43e-0321782PF00201
DomainUDPGT

UGT2B28 UGT2B11

3.43e-0321782PS00375
DomainUDP_glucos_trans

UGT2B28 UGT2B11

3.43e-0321782IPR002213
DomainIPT

PLXNA4 PLXNA1

5.65e-0327782SM00429
DomainTIG

PLXNA4 PLXNA1

7.40e-0331782PF01833
DomainSema

PLXNA4 PLXNA1

7.40e-0331782SM00630
DomainSemap_dom

PLXNA4 PLXNA1

7.40e-0331782IPR001627
DomainSema

PLXNA4 PLXNA1

7.40e-0331782PF01403
DomainSEMA

PLXNA4 PLXNA1

7.40e-0331782PS51004
DomainIPT

PLXNA4 PLXNA1

7.87e-0332782IPR002909
DomainGDS_CDC24_CS

RASGRF1 FARP1

1.15e-0239782IPR001331
PathwayREACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS

TAS2R42 TAS2R9 TAS2R7 TAS2R5 TAS2R40 GRM8

1.21e-0839596M793
PathwayWP_GPCRS_ORPHAN

GPR180 TPRA1 GPR31 GPR137B

1.02e-0619594MM15991
PathwayKEGG_TASTE_TRANSDUCTION

TAS2R42 TAS2R9 TAS2R7 TAS2R5 TAS2R40

2.42e-0652595M5785
PathwayREACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS

TAS2R42 TAS2R7 TAS2R40 GRM8

1.65e-0537594MM15067
PathwayREACTOME_GPCR_LIGAND_BINDING

TAS2R42 TAS2R9 ADRA1A TAS2R7 TAS2R5 GPR31 TACR2 TAS2R40 OPN1SW GRM8

1.96e-054635910M507
PathwayREACTOME_G_ALPHA_I_SIGNALLING_EVENTS

TAS2R42 TAS2R9 TAS2R7 TAS2R5 GPR31 TAS2R40 OPN1SW GRM8

4.58e-05314598M600
PathwayWP_SYNTHESIS_OF_CERAMIDES_AND_1DEOXYCERAMIDES

SGMS1 UGCG CERS4

1.01e-0422593M45544
PathwayREACTOME_PREDNISONE_ADME

AKR1C4 UGT2B28 UGT2B11

1.16e-0423593MM16639
PathwayREACTOME_SIGNALING_BY_GPCR

TAS2R42 TAS2R9 ADRA1A TAS2R7 TAS2R5 GPR31 TACR2 TAS2R40 OPN1SW GRM8 GPR45

1.35e-047025911M746
PathwayWP_SPHINGOLIPID_METABOLISM_OVERVIEW

SGMS1 UGCG CERS4

1.50e-0425593MM15931
PathwayWP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY

SGMS1 UGCG CERS4

1.69e-0426593M39784
PathwayWP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY

SGMS1 UGCG CERS4

1.69e-0426593MM15892
PathwayWP_SPHINGOLIPID_METABOLISM_OVERVIEW

SGMS1 UGCG CERS4

1.90e-0427593M39863
PathwayREACTOME_WAX_AND_PLASMALOGEN_BIOSYNTHESIS

FAR2 FAR1

2.56e-046592MM15480
PathwayWP_SPHINGOLIPID_PATHWAY

SGMS1 UGCG CERS4

2.61e-0430593M39501
PathwayREACTOME_WAX_AND_PLASMALOGEN_BIOSYNTHESIS

FAR2 FAR1

3.57e-047592M27730
PathwayREACTOME_GPCR_LIGAND_BINDING

TAS2R42 ADRA1A TAS2R7 GPR31 TACR2 TAS2R40 OPN1SW GRM8

3.98e-04430598MM15160
PathwayREACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS

SGMS1 PPM1L CERS4

4.89e-0437593M554
PathwayWP_GPCRS_ODORANT

GPR180 TPRA1 GPR31 GPR137B OPN1SW

4.96e-04157595MM15872
PathwayREACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION

PLXNA4 PLXNA1

6.08e-049592MM15030
PathwayREACTOME_SENSORY_PERCEPTION_OF_TASTE

TAS2R7 TAS2R5 TAS2R40

9.91e-0447593M42524
PathwayREACTOME_SPHINGOLIPID_METABOLISM

SGMS1 PPM1L UGCG CERS4

1.04e-03107594M14857
PathwayREACTOME_G_ALPHA_I_SIGNALLING_EVENTS

TAS2R42 TAS2R7 GPR31 TAS2R40 OPN1SW GRM8

1.28e-03289596MM15057
PathwayREACTOME_SIGNALING_BY_GPCR

TAS2R42 ADRA1A TAS2R7 GPR31 TACR2 TAS2R40 OPN1SW GRM8 GPR45

1.36e-03646599MM14962
PathwayREACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION

PLXNA4 PLXNA1

1.52e-0314592MM15029
PathwayREACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION

PLXNA4 PLXNA1

1.52e-0314592M7578
PathwayKEGG_STEROID_HORMONE_BIOSYNTHESIS

AKR1C4 UGT2B28 UGT2B11

1.57e-0355593M14933
PathwayREACTOME_CRMPS_IN_SEMA3A_SIGNALING

PLXNA4 PLXNA1

1.75e-0315592MM15031
PathwayREACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION

PLXNA4 PLXNA1

1.99e-0316592M16498
PathwayREACTOME_CRMPS_IN_SEMA3A_SIGNALING

PLXNA4 PLXNA1

1.99e-0316592M8245
PathwayREACTOME_OTHER_SEMAPHORIN_INTERACTIONS

PLXNA4 PLXNA1

2.81e-0319592M10959
PathwayWP_ETHER_LIPID_BIOSYNTHESIS

FAR2 FAR1

3.12e-0320592M46451
PathwayKEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450

AKR1C4 UGT2B28 UGT2B11

3.12e-0370593M16794
PathwayWP_METABOLISM_OF_SPHINGOLIPIDS_IN_ER_AND_GOLGI_APPARATUS

SGMS1 UGCG

3.44e-0321592M39459
Pubmed

Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.

TAS2R42 TAS2R9 TAS2R7 TAS2R5 TAS2R40

5.35e-092880515744053
Pubmed

Evolution of bitter taste receptors in humans and apes.

TAS2R42 TAS2R9 TAS2R7 TAS2R5 TAS2R40

1.50e-083480515496549
Pubmed

A novel family of mammalian taste receptors.

TAS2R42 TAS2R9 TAS2R7 TAS2R5

1.51e-072180410761934
Pubmed

The molecular receptive ranges of human TAS2R bitter taste receptors.

TAS2R42 TAS2R7 TAS2R5 TAS2R40

2.22e-072380420022913
Pubmed

Complexes of tetraspanins with integrins: more than meets the eye.

TSPAN15 TSPAN8 TSPAN6 CD151

2.66e-072480411739647
Pubmed

Receptors for bitter and sweet taste.

TAS2R9 TAS2R7 TAS2R5 TAS2R40

3.16e-072580412139982
Pubmed

Molecular mechanisms of bitter and sweet taste transduction.

TAS2R9 TAS2R7 TAS2R5 TAS2R40

3.73e-072680411696554
Pubmed

Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.

TAS2R9 TAS2R7 TAS2R5 TAS2R40

4.37e-072780412581520
Pubmed

Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).

ADRA1A SGMS1 PTPRN2 FARP1

1.80e-063880422952603
Pubmed

A family of candidate taste receptors in human and mouse.

TAS2R9 TAS2R7 TAS2R5

1.91e-061180310766242
Pubmed

A plethora of taste receptors.

TAS2R9 TAS2R7 TAS2R5

1.91e-061180310774719
Pubmed

T2Rs function as bitter taste receptors.

TAS2R9 TAS2R7 TAS2R5

1.91e-061180310761935
Pubmed

Complex formation of sphingomyelin synthase 1 with glucosylceramide synthase increases sphingomyelin and decreases glucosylceramide levels.

SGMS1 UGCG

5.23e-06280230242129
Pubmed

SLC35E2 promoter mutation as a prognostic marker of esophageal squamous cell carcinoma.

SLC35E2A SLC35E2B

5.23e-06280235247439
Pubmed

Quantitative analysis of UGT2B28 mRNA expression by real-time RT-PCR and application to human tissue distribution study.

UGT2B28 UGT2B11

5.23e-06280221679149
Pubmed

Topogenesis and homeostasis of fatty acyl-CoA reductase 1.

FAR2 FAR1

5.23e-06280224108123
Pubmed

Joint features and complementarities of Tspan8 and CD151 revealed in knockdown and knockout models.

TSPAN8 CD151

5.23e-06280228408484
Pubmed

Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions.

FAR2 FAR1

5.23e-06280215220348
Pubmed

Appearance of new tetraspanin genes during vertebrate evolution.

TSPAN15 TSPAN8 TSPAN6

1.30e-052080318291621
Pubmed

Structural Basis for Plexin Activation and Regulation.

PLXNA4 PLXNA1

1.57e-05380227397516
Pubmed

New insights into the role of tetraspanin 6, 7, and 8 in physiology and pathology.

TSPAN8 TSPAN6

1.57e-05380239031113
Pubmed

Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells.

PLXNA4 PLXNA1

1.57e-05380218625214
Pubmed

Cloning and immunocytochemical localization of a cyclic nucleotide-gated channel alpha-subunit to all cone photoreceptors in the mouse retina.

OPN1SW CNGA3

1.57e-05380210813773
Pubmed

Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family.

FAR2 FAR1

1.57e-05380215220349
Pubmed

Dysregulated sphingolipid metabolism in endometriosis.

SGMS1 UGCG

1.57e-05380224960545
Pubmed

Evolutionary relationships of the Tas2r receptor gene families in mouse and human.

TAS2R42 TAS2R7 TAS2R40

1.75e-052280312734386
Pubmed

Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol.

TAS2R42 TAS2R40

3.13e-05480223632330
Pubmed

Modulation of ceramide metabolism in mouse primary macrophages.

SGMS1 UGCG

3.13e-05480220637730
Pubmed

Chromosome assignment of four plexin A genes (Plxna1, Plxna2, Plxna3, Plxna4) in mouse, rat, Syrian hamster and Chinese hamster.

PLXNA4 PLXNA1

3.13e-05480211306810
Pubmed

PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.

PLXNA4 PLXNA1

3.13e-05480225518740
Pubmed

Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.

SGMS1 UGCG CERS4

3.29e-052780323096701
Pubmed

Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.

SGMS1 UGCG CERS4

3.29e-052780325269881
Pubmed

Adaptive diversification of bitter taste receptor genes in Mammalian evolution.

TAS2R42 TAS2R7 TAS2R40

4.55e-053080312679530
Pubmed

Identification of gene products suppressed by human immunodeficiency virus type 1 infection or gp120 exposure of primary human astrocytes by rapid subtraction hybridization.

RASGRF1 CD151

5.20e-05580212775420
Pubmed

Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points.

PLXNA4 PLXNA1

1.09e-04780219063725
Pubmed

Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development.

UGT2B28 UGT2B11

1.09e-04780226074487
Pubmed

Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice.

PLXNA4 PLXNA1

1.09e-04780219655386
Pubmed

The expression of plexins during mouse embryogenesis.

PLXNA4 PLXNA1

1.45e-04880215661641
Pubmed

Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.

UGT2B28 UGT2B11

1.45e-04880232093886
Pubmed

Integration of opposing semaphorin guidance cues in cortical axons.

PLXNA4 PLXNA1

1.45e-04880222368082
Pubmed

Genetic variations strongly influence phenotypic outcome in the mouse retina.

RBL1 CD151 OPN1SW

1.66e-044680321779340
Pubmed

Control of species-dependent cortico-motoneuronal connections underlying manual dexterity.

PLXNA4 PLXNA1

1.86e-04980228751609
Pubmed

The role of neuropilins in cell signalling.

PLXNA4 PLXNA1

1.86e-04980219909241
Pubmed

Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development.

PLXNA4 PLXNA1

2.32e-041080218804103
Pubmed

Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

SLC35E2A SLC35E2B TMEM63A

2.98e-04568039455484
Pubmed

Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability.

PLXNA4 PLXNA1

3.40e-041280225839327
Pubmed

PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons.

PLXNA4 PLXNA1

3.40e-041280231690636
Pubmed

On and off retinal circuit assembly by divergent molecular mechanisms.

PLXNA4 PLXNA1

3.40e-041280224179230
Pubmed

Transcriptome profiling reveals expression signatures of cranial neural crest cells arising from different axial levels.

PLXNA4 PLXNA1

3.40e-041280228407732
Pubmed

Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.

PLXNA4 PLXNA1

3.40e-041280221270798
Pubmed

Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions.

TSPAN8 CD151

3.40e-041280210229664
Pubmed

Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons.

PLXNA4 PLXNA1

3.40e-041280223991118
Pubmed

Plexin signaling via off-track and rho family GTPases.

PLXNA4 PLXNA1

4.01e-041380211604131
Pubmed

Functional assembly of accessory optic system circuitry critical for compensatory eye movements.

PLXNA4 PLXNA1

4.01e-041380225959730
Pubmed

Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.

PLXNA4 PLXNA1

4.01e-041380210520995
Pubmed

Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice.

TAS2R42 TAS2R7

4.01e-041380215938754
Pubmed

Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation.

PLXNA4 PLXNA1

4.01e-041380222723296
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

GPR180 MEGF8 FKTN PIEZO1 PPM1L KIAA0319L CD151 LTBR PLXNA1 SOAT1

4.27e-041201801035696571
Pubmed

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

TSPAN15 LAPTM4A ATP13A4 DERL1 TNFSF18 TSPAN6 PLXNA4 FAR1 SLC44A3

4.34e-0498580912975309
Pubmed

Genetic and physical delineation of the region overlapping the progressive motor neuropathy (pmn) locus on mouse chromosome 13.

GPR137B HEATR1

4.67e-041480211472062
Pubmed

β3GnT2 maintains adenylyl cyclase-3 signaling and axon guidance molecule expression in the olfactory epithelium.

PLXNA4 PLXNA1

4.67e-041480221525298
Pubmed

The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1.

RBL1 GRAMD4

4.67e-041480216600870
Pubmed

A midline switch of receptor processing regulates commissural axon guidance in vertebrates.

PLXNA4 PLXNA1

4.67e-041480220159958
Pubmed

Exploration of human ORFeome: high-throughput preparation of ORF clones and efficient characterization of their protein products.

PTPRN2 PIEZO1

5.38e-041580218316326
Pubmed

Ciliopathy-associated IQCB1/NPHP5 protein is required for mouse photoreceptor outer segment formation.

OPN1SW CNGA3

6.14e-041680227328943
Pubmed

Expression of the semaphorins Sema 3D and Sema 3F in the developing parathyroid and thymus.

PLXNA4 PLXNA1

6.14e-041680218489001
Pubmed

Allocation of paraventricular and supraoptic neurons requires Sim1 function: a role for a Sim1 downstream gene PlexinC1.

PLXNA4 PLXNA1

6.14e-041680217356169
Pubmed

Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing.

PLXNA4 PLXNA1

6.14e-041680222632726
Pubmed

Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.

PLXNA4 PLXNA1

6.95e-041780211683995
Pubmed

Semaphorin signaling facilitates cleft formation in the developing salivary gland.

PLXNA4 PLXNA1

6.95e-041780217626059
Pubmed

Biochemistry of mammalian peroxisomes revisited.

FAR2 FAR1

9.66e-042080216756494
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TPRA1 MEGF8 PCNX3 PIEZO1 DOCK9 KIAA0319L TTYH3 SLC35E2B PLXNA1

9.82e-04110580935748872
Pubmed

A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP).

TACR2 GRM8

1.07e-032180215452121
Pubmed

Evolutionarily conserved regulators of tau identify targets for new therapies.

LAPTM4A KIAA0319L TTYH3 FAR1 PLXNA1 SOAT1

1.23e-0351680636610398
Pubmed

Establishment of a cone photoreceptor transplantation platform based on a novel cone-GFP reporter mouse line.

OPN1SW CNGA3

1.28e-032380226965927
Pubmed

A semaphorin code defines subpopulations of spinal motor neurons during mouse development.

PLXNA4 PLXNA1

1.40e-032480215869472
Pubmed

A radial axis defined by semaphorin-to-neuropilin signaling controls pancreatic islet morphogenesis.

PLXNA4 PLXNA1

1.40e-032480228893946
Pubmed

Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter.

PPM1L SLC6A5

1.77e-032780234709416
Pubmed

Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.

PLXNA4 PLXNA1

1.90e-032880218617019
Pubmed

The human (PEDB) and mouse (mPEDB) Prostate Expression Databases.

RASGRF1 TSPAN8 CD151

1.91e-0310680311752298
Pubmed

An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophrenia.

GPR180 DOCK9

2.04e-032980211991713
Pubmed

Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains.

TPRA1 TAS2R7

2.18e-033080217273929
InteractionSNX19 interactions

TSPAN15 DERL1 PTPRN2 TSPAN8 SLC6A5

1.92e-0656745int:SNX19
InteractionSLC30A7 interactions

TSPAN15 TSPAN8 FHIP2A GPR45 TMEM63A

1.52e-0585745int:SLC30A7
InteractionFAM241B interactions

TSPAN15 TPRA1 ADRA1A TSPAN8 GPR45

2.01e-0590745int:FAM241B
InteractionVNN2 interactions

FAR2 TSPAN6 SLC30A9 SOAT1

3.13e-0549744int:VNN2
InteractionSTUM interactions

PIEZO1 TSPAN6 SOAT1

6.03e-0521743int:STUM
InteractionSIGMAR1 interactions

TSPAN15 TMEM72 SLC6A5 GPR45 TMEM63A

7.08e-05117745int:SIGMAR1
InteractionTTYH1 interactions

FAR2 PCNX3 PIEZO1 PPM1L CERS4 SOAT1 TMEM63A

1.16e-04300747int:TTYH1
InteractionTSPAN2 interactions

TSPAN15 PIEZO1 CD151 TTYH3

1.21e-0469744int:TSPAN2
InteractionTMEM186 interactions

TSPAN15 PTPRN2 TSPAN8 SLC6A5

1.21e-0469744int:TMEM186
InteractionRETREG3 interactions

TSPAN15 DERL1 TNFSF18 TSPAN8 SLC6A5 TTYH3

1.66e-04222746int:RETREG3
InteractionUGT2B28 interactions

UGT2B28 UGT2B11

1.98e-046742int:UGT2B28
InteractionTMEM63B interactions

TSPAN15 TPRA1 TSPAN8 SOAT1 TMEM63A

2.07e-04147745int:TMEM63B
InteractionATP2A3 interactions

GPR180 TSPAN15 FAR2 PIEZO1 CNGA3 GPR45

2.10e-04232746int:ATP2A3
InteractionLPCAT3 interactions

TSPAN15 TNFSF18 TMEM72 TSPAN8

2.14e-0480744int:LPCAT3
InteractionSEMA5A interactions

PLXNA4 PLXNA1

2.76e-047742int:SEMA5A
InteractionUGT2B11 interactions

UGT2B28 UGT2B11

2.76e-047742int:UGT2B11
InteractionENTREP1 interactions

PCNX3 TTYH3 SOAT1 TMEM63A

2.83e-0486744int:ENTREP1
InteractionPTDSS2 interactions

TSPAN15 TMEM72 GPR45 TMEM63A

3.23e-0489744int:PTDSS2
InteractionTMEM41B interactions

DERL1 TMEM72 HEATR1 SOAT1 TMEM63A

3.25e-04162745int:TMEM41B
InteractionASGR2 interactions

DERL1 TTYH3 SLC30A9 SOAT1

3.52e-0491744int:ASGR2
InteractionSLC25A52 interactions

TSPAN15 TSPAN8

3.67e-048742int:SLC25A52
InteractionMS4A15 interactions

PCNX3 PIEZO1 TMEM63A

3.95e-0439743int:MS4A15
InteractionTMEM68 interactions

TSPAN15 TNFSF18 TSPAN8

4.26e-0440743int:TMEM68
InteractionTMEM126A interactions

TSPAN15 TNFSF18 SLC6A5 TMEM63A

4.66e-0498744int:TMEM126A
InteractionSCN4A interactions

TSPAN15 PPM1L TSPAN6 SOAT1

4.66e-0498744int:SCN4A
InteractionSC5D interactions

TSPAN15 TPRA1 TMEM63A

4.92e-0442743int:SC5D
InteractionTSPAN15 interactions

TSPAN15 FAR2 PCNX3 PIEZO1 TSPAN6 SLC30A9

5.31e-04276746int:TSPAN15
InteractionMBOAT7 interactions

TSPAN15 TPRA1 ADRA1A SOAT1 TMEM63A

5.53e-04182745int:MBOAT7
InteractionTMEM63A interactions

GPR180 TPRA1 DERL1 TMEM63A

5.63e-04103744int:TMEM63A
InteractionKDSR interactions

TSPAN15 TNFSF18 TSPAN6 TTYH3

5.63e-04103744int:KDSR
InteractionGPRC5C interactions

TSPAN15 TNFSF18 GPR45 TMEM63A

5.63e-04103744int:GPRC5C
InteractionATL2 interactions

DERL1 SLC6A5 CNGA3 GPR45

5.84e-04104744int:ATL2
InteractionCERS6 interactions

TSPAN15 TNFSF18 SLC6A5 CERS4

5.84e-04104744int:CERS6
InteractionYIPF3 interactions

PCNX3 PIEZO1 SLC6A5 GPR45 SOAT1

6.11e-04186745int:YIPF3
Cytoband12p13

TAS2R42 TAS2R9 TAS2R7 LTBR

5.02e-066480412p13
CytobandEnsembl 112 genes in cytogenetic band chr13q32

GPR180 FARP1 DOCK9

6.48e-0496803chr13q32
Cytoband4q13.2

UGT2B28 UGT2B11

1.35e-03318024q13.2
Cytoband10q22.1

TSPAN15 TACR2

2.95e-034680210q22.1
CytobandEnsembl 112 genes in cytogenetic band chr12p13

TAS2R42 TAS2R9 TAS2R7 LTBR

3.43e-03353804chr12p13
GeneFamilyTaste 2 receptors

TAS2R42 TAS2R9 TAS2R7 TAS2R5 TAS2R40

1.26e-07395651162
GeneFamilyCD molecules|Tetraspanins

TSPAN15 TSPAN8 TSPAN6 CD151

3.16e-0633564768
GeneFamilySolute carriers

SLC37A1 SLC35E2A SLC6A5 SLC35E2B SLC30A9 SLC48A1 SLC44A3 SLC35F4

2.75e-05395568752
GeneFamilyPlexins

PLXNA4 PLXNA1

3.35e-049562683
GeneFamilyUDP glucuronosyltransferases

UGT2B28 UGT2B11

4.40e-0332562363
CoexpressionMILI_PSEUDOPODIA_HAPTOTAXIS_DN

SGMS1 PCNX3 SLC35E2A PIEZO1 TMBIM4 PPM1L TSPAN6 CD151 CTNS SLC35E2B GRAMD4 PLXNA1 SOAT1 TMEM63A

1.30e-087037614MM1055
CoexpressionMILI_PSEUDOPODIA_HAPTOTAXIS_DN

SGMS1 PCNX3 PIEZO1 TMBIM4 PPM1L TSPAN6 CD151 CTNS SLC35E2B GRAMD4 PLXNA1 SOAT1 TMEM63A

7.45e-086817613M5314
CoexpressionHE_LIM_SUN_FETAL_LUNG_C2_APOE_POS_M2_MACROPHAGE_CELL

TSPAN15 DERL1 FARP1 GPR137B CD151 SLC48A1 GRAMD4 PLXNA1 CERS4

9.66e-06476769M45717
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TSPAN15 LAPTM4A SCN7A TSPAN8 CD151 SLC48A1

1.29e-0619280653d438e35c14e7656585942b788459e6d843c555
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TSPAN15 LAPTM4A SCN7A TSPAN8 CD151 SLC48A1

1.29e-061928069a1aeac3ecf31f865a23d8ee15a82aef31779089
ToppCellfacs-Lung-18m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TSPAN15 SCN7A TSPAN8 TTYH3 SLC48A1 PLXNA1

1.41e-061958067e0ef92059ff34e368d2324815f49b50e3ca7332
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLC37A1 PTPRN2 FARP1 PPM1L SLC44A3 TMEM63A

1.64e-062008060eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PIEZO1 DOCK9 DNAJC5G CD151 KLKB1

2.49e-051928055388f3115ab285f3f3001af1d71543ed64b9e044
ToppCelldroplet-Lung-nan-21m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN15 DOCK9 SCN7A TSPAN8 CD151

2.55e-05193805ae35c5757a88b02f8b9f94a0af4c3396ca828cc3
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLC37A1 PTPRN2 TSPAN8 SLC44A3 TMEM63A

3.03e-05200805c450a15e21fa72d071ed6e3b9f22de557a0f3cea
ToppCellTracheal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PTPRN2 FARP1 PPM1L SLC44A3 TMEM63A

3.03e-05200805d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
Drug(+) -Levobunolol hydrochloride [47141-41-3]; Up 200; 12.2uM; HL60; HT_HG-U133A

SLC37A1 ADRA1A SGMS1 TNFSF18 RASGRF1 FARP1 TMEM63A

5.40e-061967973016_UP
Drugrotenone; Down 200; 1uM; MCF7; HT_HG-U133A

OVGP1 CASD1 MEGF8 TNFSF18 RBL1 CTNS GRAMD4

5.78e-061987975915_DN
DrugAustricine [10180-88-8]; Down 200; 14.2uM; PC3; HT_HG-U133A

TPRA1 PTPRN2 KIAA0319L AKR1C4 CTNS GRM8 TMEM63A

6.17e-062007974213_DN
DiseaseColor Blindness, Blue

OPN1SW CNGA3

1.03e-046782C0155017
Diseasepersulfide dioxygenase ETHE1, mitochondrial measurement

SLC48A1 KLKB1

4.48e-0412782EFO_0008258
Diseasetransmembrane protein 87B measurement

SLC48A1 KLKB1

5.28e-0413782EFO_0802158
Diseaseneuronal ceroid lipofuscinosis (implicated_via_orthology)

ATP13A4 DNAJC5G

6.15e-0414782DOID:14503 (implicated_via_orthology)
Diseasea disintegrin and metalloproteinase with thrombospondin motifs 13 measurement

SLC48A1 KLKB1

9.14e-0417782EFO_0008011
Diseasephosphatidylcholine 36:4 measurement

UGT2B28 UGT2B11

1.03e-0318782EFO_0010382
Diseaseresponse to xenobiotic stimulus

ADRA1A SGMS1 PTPRN2 FARP1

1.40e-03182784GO_0009410
Diseasepartial thromboplastin time

SLC48A1 KLKB1

1.83e-0324782EFO_0004310
Diseaselifestyle measurement

CWH43 FARP1 FHIP2A GRM8

3.53e-03235784EFO_0010724

Protein segments in the cluster

PeptideGeneStartEntry
FWSFIYSVAALACIA

ABCA5

1136

Q8WWZ7
REDIFYTSKLWCTFF

AKR1C4

76

P17516
KKFCEASWRFLFYLS

CERS4

131

Q9HA82
FYIFQLFSVCLWFSE

ATP13A4

206

Q4VNC1
TVFKIVFWLGYLNSC

ADRA1A

306

P35348
QKLYVALWAAFLASC

GRAMD4

336

Q6IC98
CLPFLAAFYLSLQAW

GPR31

66

O00270
FFALASALWFLICKR

C1orf185

26

Q5T7R7
LFFLLYRWCSNKKNA

KIR3DL2

356

P43630
WCEDFLVRSFYLKNL

PTPRN2

881

Q92932
NVWFFIVSFCYKFLS

FAR2

491

Q96K12
FEWNLFLFTYRDCLS

TCTE1

256

Q5JU00
NIWYFVVSLCYKFLS

FAR1

491

Q8WVX9
WILCLSGFLKFFFYS

TMBIM4

161

Q9HC24
KWLRSLYLFYTCFCF

KIAA0319L

26

Q8IZA0
LFIIFKAYLINCVWN

LAPTM4A

171

Q15012
TLLFGALTSLFLWYC

ASPHD1

81

Q5U4P2
SNCFHLYVWIFLLIF

PCNX3

31

Q9H6A9
LLKGFFTDIWVFQFC

PCNX3

811

Q9H6A9
LTNWFTFLLYKFLKE

PLXNA1

1441

Q9UIW2
WFTFLLYKFLKECAG

PLXNA4

1441

Q9HCM2
IVSFWFGTRFKACYL

DERL1

141

Q9BUN8
FSCFFLFLSLCVLLW

MEGF8

2656

Q7Z7M0
FYITFAKGCILWFLC

GPR180

356

Q86V85
ILCLFWLYFFSFLRL

TMEM63A

676

O94886
CPCFFLLTAKFYWIL

GRM8

11

O00222
YLCVSFLKTIFWSRN

NPIPB15

81

A6NHN6
FCRLSATLYWFFVLE

GPR45

106

Q9Y5Y3
SFISFKWAFLLSLYA

SLC48A1

116

Q6P1K1
ICKKWFPYFLVRFTV

METTL7A

31

Q9H8H3
YFILNSCWFKTLVIL

DNAJC5G

116

Q8N7S2
LLFAKLVSYTFLFWL

SLC37A1

336

P57057
AWFGKISLELFICQY

CASD1

701

Q96PB1
LTSNKLLKYSWFFFD

DOCK9

951

Q9BZ29
KLWVVFTNFCLFFYK

FARP1

951

Q9Y4F1
EWACKLYTGFVFLTF

GPR32P1

111

Q8NGA4
TLCFSKLDYAVAWFI

UGCG

341

Q16739
KYLFPKFTLCWTEFV

FKTN

391

O75072
NCLFFTFYTNVWKIE

KLKB1

236

P03952
WILLFHFYFTCSFKT

CXorf1

66

O96002
YRKCTDTAWLFLFFL

SLC44A3

26

Q8N4M1
FQLFKFCSVLWTYGS

HEATR1

861

Q9H583
TWLQFLFCFSYIKLA

CTNS

261

O60931
ALISFLSWFDYCDQL

FHIP2A

356

Q5W0V3
LKYLLFTYNCCFWLA

CD151

16

P48509
CHKFIQQVYLALFWL

TACR2

281

P21452
LCIFWFSLKEINFNA

OR52N5

91

Q8NH56
FLAYFEICSFVWGAK

OVGP1

296

Q12889
KWYSSPLLFCFELVL

PGBD3

481

Q8N328
RSESYTWFLFIFCFI

OPN1SW

196

P03999
IFYLLEIFFCAWCTA

CWH43

321

Q9H720
SYQSVFLFLCLFWAS

GPR137B

76

O60478
FAAWLKVFYCLRIAN

TAS2R40

111

P59535
TTWLATCLSIFYFFK

TAS2R42

96

Q7RTR8
ILFLTFFAFLHCWLN

SOAT1

376

P35610
PTILTFILCFSFYQW

SLC6A5

686

Q9Y345
KDLFNFCWTLFVYTK

RBL1

171

P28749
KNRTLDEYFTCLFLW

PRAMEF20

156

Q5VT98
LFLLCISLALWSYFF

PPM1L

26

Q5SGD2
LLYLTLWFFFSFCTL

SLC35E2A

76

P0CK97
LWFFFSFCTLFLNKY

SLC35E2A

81

P0CK97
LFCCNKAFVFLLSWI

SLC35F4

281

A4IF30
TKWFALLQNLLFYFE

RASGRF1

41

Q13972
WNACIYFAISKFIGF

CNGA3

316

Q16281
SIWFATCLSIYYFFK

TAS2R7

96

Q9NYW3
ASLWFATFLSVFYCK

TAS2R5

91

Q9NYW4
RQFWLVSSCFFFLVY

TPRA1

191

Q86W33
CLLRAQFSDFKWELY

THAP9

186

Q9H5L6
SLWFTSCLSIFYLLK

TAS2R9

96

Q9NYW1
FLLYFSCSLFTAALW

TMEM250

56

H0YL14
LFLCSFSWLIFIFLQ

TNFSF18

36

Q9UNG2
YCARFSYLWLKFSLI

TSPAN15

11

O95858
EWGKTFLAFLYALSC

SGMS1

131

Q86VZ5
CFKSVLLIYTFIFWI

TSPAN6

16

O43657
LLYLTLWFFFSFCTL

SLC35E2B

76

P0CK96
LWFFFSFCTLFLNKY

SLC35E2B

81

P0CK96
FIITKFCLFCFWKFA

UGT2B11

506

O75310
FFLLLATVFSCIWKS

LTBR

236

P36941
INGLNCFFKFLAWIY

SLC30A9

246

Q6PML9
CFFKFLAWIYTGSAS

SLC30A9

251

Q6PML9
KLIAFRCFYFTIAWN

SCN7A

1301

Q01118
CLTLFQVYYSLWRKL

PIEZO1

611

Q92508
WLGCFQKFLAYLLLS

TMEM72

86

A0PK05
FVVTKFCLFCFWKFA

UGT2B28

506

Q9BY64
LDLLFLLFYSFWLCC

TTYH3

56

Q9C0H2
ACIKYSMFTFNFLFW

TSPAN8

6

P19075