Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionserine-type peptidase activity

DPP7 PCSK5 TPP2 BMP1 HPR LPA MMP2 PLG CFB

1.59e-07207819GO:0008236
GeneOntologyMolecularFunctionserine hydrolase activity

DPP7 PCSK5 TPP2 BMP1 HPR LPA MMP2 PLG CFB

1.95e-07212819GO:0017171
GeneOntologyMolecularFunctioncalcium ion binding

BMP1 FAT2 DSC2 DSC3 MATN3 FSTL5 PCDHB5 PCDHB12 CAPNS2 UMOD LTBP2 EML1 SMOC1 EFCAB7 RYR2

2.89e-077498115GO:0005509
GeneOntologyMolecularFunctionserine-type endopeptidase activity

PCSK5 TPP2 BMP1 HPR LPA MMP2 PLG CFB

1.03e-06190818GO:0004252
GeneOntologyMolecularFunctionpeptidase activity

DPP7 PCSK5 TPP2 DPEP1 BMP1 HPR LPA PEPD CAPNS2 CASP6 MMP2 PLG CFB

2.15e-066548113GO:0008233
GeneOntologyMolecularFunctionendopeptidase activity

PCSK5 TPP2 BMP1 HPR LPA CAPNS2 CASP6 MMP2 PLG CFB

9.28e-064308110GO:0004175
GeneOntologyMolecularFunctionaminopeptidase activity

DPP7 TPP2 PEPD

7.06e-0443813GO:0004177
GeneOntologyMolecularFunctionserine-type exopeptidase activity

DPP7 TPP2

1.04e-0312812GO:0070008
GeneOntologyMolecularFunctionexopeptidase activity

DPP7 TPP2 DPEP1 PEPD

1.05e-03110814GO:0008238
GeneOntologyBiologicalProcessrenal urate salt excretion

UMOD ABCG2

4.23e-053782GO:0097744
GeneOntologyBiologicalProcesscell-cell adhesion

CFH FAT2 SRPX2 ABL2 DSC2 CCM2L DSC3 HLA-DRB5 PCDHB5 PCDHB12 UMOD PLG CTNND2 LILRB1

4.60e-0510777814GO:0098609
GeneOntologyBiologicalProcessextracellular matrix organization

BMP1 ABL2 LPA MATN3 PRDX4 MMP2 PLG SMOC1

8.89e-05377788GO:0030198
GeneOntologyBiologicalProcessextracellular structure organization

BMP1 ABL2 LPA MATN3 PRDX4 MMP2 PLG SMOC1

9.06e-05378788GO:0043062
GeneOntologyBiologicalProcessexternal encapsulating structure organization

BMP1 ABL2 LPA MATN3 PRDX4 MMP2 PLG SMOC1

9.22e-05379788GO:0045229
GeneOntologyBiologicalProcesspositive regulation of fibrinolysis

LPA PLG

1.40e-045782GO:0051919
GeneOntologyBiologicalProcesslearning

ABL2 CNTNAP2 SORCS3 GRIN2A CTNND2 CSMD1

1.52e-04212786GO:0007612
GeneOntologyCellularComponentcell surface

CFH SRPX2 FCRL3 ARSB LPA HLA-DRB5 ROR1 CNTNAP2 UMOD ABCG2 GRIN2A PLG OCLN LILRB1 IGSF3

1.52e-0511117915GO:0009986
GeneOntologyCellularComponentside of membrane

CFH DPEP1 PTPN4 FCRL3 LPA HLA-DRB5 UMOD ABCG2 PLG EFCAB7 LILRB1 RYR2

1.04e-048757912GO:0098552
GeneOntologyCellularComponentextracellular matrix

BMP1 SRPX2 FCGBP LPA MATN3 LTBP2 MMP2 PLG SMOC1 MUC5AC

1.77e-046567910GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

BMP1 SRPX2 FCGBP LPA MATN3 LTBP2 MMP2 PLG SMOC1 MUC5AC

1.82e-046587910GO:0030312
MousePhenoabnormal conjunctival epithelium morphology

LPA PLG MUC5AC

3.47e-067663MP:0004481
MousePhenoabnormal kidney thrombosis

CFH LPA PLG

1.18e-0510663MP:0011507
MousePhenoabnormal mammary gland connective tissue morphology

LPA PLG

2.20e-052662MP:0009507
MousePhenoectropion

LPA PLG

2.20e-052662MP:0006164
MousePhenoesophageal ulcer

LPA PLG

2.20e-052662MP:0004547
MousePhenoduodenal ulcer

LPA PLG

2.20e-052662MP:0003273
MousePhenoperianal ulcer

LPA PLG

2.20e-052662MP:0005035
MousePhenoabnormal conjunctiva morphology

LPA PLG MUC5AC

2.78e-0513663MP:0001310
MousePhenoabnormal anus morphology

PCSK5 LPA PLG

2.78e-0513663MP:0005034
MousePhenoincreased hepatocyte proliferation

LPA PLG NR1H4

6.52e-0517663MP:0003893
MousePhenoabsent cornea epithelium

LPA PLG

6.57e-053662MP:0020856
MousePhenoincreased circulating fibrinogen level

LPA PLG

1.31e-044662MP:0012331
MousePhenoproctitis

LPA PLG

1.31e-044662MP:0003305
MousePhenoabnormal uvea morphology

CFH CRYGD LPA LTBP2 PLG SMOC1 EDDM3A

1.36e-04241667MP:0005197
MousePhenodecreased tumor growth/size

CCM2L LPA MMP2 PLG

2.33e-0464664MP:0003447
MousePhenoabnormal esophagus morphology

PCSK5 LPA KEAP1 PLG

2.62e-0466664MP:0000467
MousePhenoabnormal anal canal morphology

PCSK5 LPA PLG

2.71e-0427663MP:0009053
MousePhenoabnormal ocular surface morphology

ARSB LPA PLG MUC5AC

2.78e-0467664MP:0013754
MousePhenogastric ulcer

LPA PLG

3.25e-046662MP:0003282
MousePhenoincreased acute phase protein level

LPA PLG

4.54e-047662MP:0014499
MousePhenovenoocclusion

LPA PLG

4.54e-047662MP:0006137
MousePhenopeptic ulcer

LPA PLG

4.54e-047662MP:0003301
MousePhenoabnormal stomach mucosa morphology

LPA KEAP1 PLG OCLN

4.73e-0477664MP:0010792
MousePhenoabnormal stomach wall morphology

LPA KEAP1 PLG OCLN

5.48e-0480664MP:0010783
MousePhenoabnormal trachea morphology

PCSK5 ARSB LPA PLG

5.74e-0481664MP:0002282
MousePhenoabnormal anterior eye segment morphology

CFH CRYGD ARSB DSC2 LPA PEPD CASP6 LTBP2 ABCG2 MMP2 PLG SMOC1 MUC5AC EDDM3A

6.01e-0411176614MP:0005193
MousePhenoabnormal circulating fibrinogen level

LPA PLG

6.04e-048662MP:0010213
MousePhenodecreased keratinocyte migration

LPA PLG

6.04e-048662MP:0012194
MousePhenoincreased urine uric acid level

UMOD ABCG2

6.04e-048662MP:0009810
MousePhenoabsent fibula

PCSK5 SMOC1

6.04e-048662MP:0005430
MousePhenodecreased susceptibility to neuronal excitotoxicity

LPA CASP6 PLG

6.96e-0437663MP:0008236
MousePhenoincreased stomach mucosa thickness

KEAP1 OCLN

7.74e-049662MP:0005211
MousePhenoabnormal eyelid morphology

DSC2 LPA EML1 MMP2 PLG SMOC1

7.93e-04233666MP:0001340
MousePhenodecreased susceptibility to induced choroidal neovascularization

LPA PLG

9.64e-0410662MP:0003434
MousePhenodecreased circulating phosphate level

SRPX2 RAVER2 UMOD CFB

9.65e-0493664MP:0000198
MousePhenodecreased phosphate level

SRPX2 RAVER2 UMOD CFB

1.00e-0394664MP:0014546
MousePhenoabnormal cornea epithelium morphology

ARSB LPA PLG

1.01e-0342663MP:0006000
MousePhenoabnormal rectum morphology

PCSK5 LPA PLG

1.08e-0343663MP:0000492
MousePhenoabnormal stomach morphology

LPA PEPD KEAP1 MMP2 PLG OCLN

1.10e-03248666MP:0000470
MousePhenostomach mucosa hyperplasia

KEAP1 OCLN

1.17e-0311662MP:0010799
MousePhenoabnormal keratinocyte migration

LPA PLG

1.17e-0311662MP:0012192
DomainEGF

PCSK5 BMP1 CNTNAP3B FAT2 FCGBP MATN3 CNTNAP2 CNTNAP3 UMOD LTBP2

4.89e-082357810SM00181
DomainEGF-like_dom

PCSK5 BMP1 CNTNAP3B FAT2 FCGBP MATN3 CNTNAP2 CNTNAP3 UMOD LTBP2

8.42e-082497810IPR000742
DomainSUSHI

CFH SRPX2 HPR CSMD1 CSMD2 CFB

1.20e-0756786PS50923
DomainSushi_SCR_CCP_dom

CFH SRPX2 HPR CSMD1 CSMD2 CFB

1.34e-0757786IPR000436
DomainEGF

BMP1 FAT2 MATN3 CNTNAP2 CNTNAP3 UMOD LTBP2

9.55e-07126787PF00008
DomainSushi

CFH SRPX2 CSMD1 CSMD2 CFB

2.49e-0652785PF00084
DomainCCP

CFH SRPX2 CSMD1 CSMD2 CFB

3.01e-0654785SM00032
DomainEGF_3

BMP1 CNTNAP3B FAT2 MATN3 CNTNAP2 CNTNAP3 UMOD LTBP2

6.13e-06235788PS50026
DomainKringle-like

LPA ROR1 MMP2 PLG

9.26e-0632784IPR013806
DomainEGF_2

BMP1 CNTNAP3B FAT2 MATN3 CNTNAP2 CNTNAP3 UMOD LTBP2

1.47e-05265788PS01186
DomainLAM_G_DOMAIN

CNTNAP3B FAT2 CNTNAP2 CNTNAP3

1.87e-0538784PS50025
DomainLaminin_G_2

CNTNAP3B FAT2 CNTNAP2 CNTNAP3

2.29e-0540784PF02210
DomainLamG

CNTNAP3B FAT2 CNTNAP2 CNTNAP3

3.37e-0544784SM00282
DomainKringle

LPA ROR1 PLG

4.57e-0517783IPR000001
DomainKringle_CS

LPA ROR1 PLG

4.57e-0517783IPR018056
DomainKRINGLE_2

LPA ROR1 PLG

4.57e-0517783PS50070
DomainKringle

LPA ROR1 PLG

4.57e-0517783PF00051
DomainKRINGLE_1

LPA ROR1 PLG

4.57e-0517783PS00021
DomainKR

LPA ROR1 PLG

4.57e-0517783SM00130
DomainFA58C

CNTNAP3B CNTNAP2 CNTNAP3

8.83e-0521783SM00231
DomainFA58C_3

CNTNAP3B CNTNAP2 CNTNAP3

8.83e-0521783PS50022
DomainFA58C_1

CNTNAP3B CNTNAP2 CNTNAP3

8.83e-0521783PS01285
DomainFA58C_2

CNTNAP3B CNTNAP2 CNTNAP3

8.83e-0521783PS01286
DomainCadherin_CS

FAT2 DSC2 DSC3 PCDHB5 PCDHB12

9.29e-05109785IPR020894
DomainEGF_1

BMP1 CNTNAP3B FAT2 CNTNAP2 CNTNAP3 UMOD LTBP2

9.43e-05255787PS00022
DomainLaminin_G

CNTNAP3B FAT2 CNTNAP2 CNTNAP3

1.01e-0458784IPR001791
DomainEGF-like_CS

BMP1 FAT2 MATN3 CNTNAP2 CNTNAP3 UMOD LTBP2

1.09e-04261787IPR013032
DomainCADHERIN_1

FAT2 DSC2 DSC3 PCDHB5 PCDHB12

1.10e-04113785PS00232
DomainCadherin

FAT2 DSC2 DSC3 PCDHB5 PCDHB12

1.10e-04113785PF00028
DomainCADHERIN_2

FAT2 DSC2 DSC3 PCDHB5 PCDHB12

1.15e-04114785PS50268
Domain-

FAT2 DSC2 DSC3 PCDHB5 PCDHB12

1.15e-041147852.60.40.60
DomainCA

FAT2 DSC2 DSC3 PCDHB5 PCDHB12

1.20e-04115785SM00112
DomainCadherin-like

FAT2 DSC2 DSC3 PCDHB5 PCDHB12

1.25e-04116785IPR015919
DomainF5_F8_type_C

CNTNAP3B CNTNAP2 CNTNAP3

1.33e-0424783PF00754
DomainFA58C

CNTNAP3B CNTNAP2 CNTNAP3

1.33e-0424783IPR000421
DomainCadherin

FAT2 DSC2 DSC3 PCDHB5 PCDHB12

1.35e-04118785IPR002126
DomainEGF_CA

BMP1 FAT2 MATN3 UMOD LTBP2

1.58e-04122785SM00179
DomainEGF-like_Ca-bd_dom

BMP1 FAT2 MATN3 UMOD LTBP2

1.70e-04124785IPR001881
DomainVPS10

SORCS3 SORCS1

1.71e-045782SM00602
DomainSortilin_C

SORCS3 SORCS1

1.71e-045782PF15901
DomainSortilin-Vps10

SORCS3 SORCS1

1.71e-045782PF15902
DomainVPS10

SORCS3 SORCS1

1.71e-045782IPR006581
DomainSortilin_N

SORCS3 SORCS1

1.71e-045782IPR031778
DomainSortilin_C

SORCS3 SORCS1

1.71e-045782IPR031777
DomainFIBRINOGEN_C_1

CNTNAP3B CNTNAP2 CNTNAP3

3.19e-0432783PS00514
DomainFibrinogen_a/b/g_C_dom

CNTNAP3B CNTNAP2 CNTNAP3

3.19e-0432783IPR002181
DomainFIBRINOGEN_C_2

CNTNAP3B CNTNAP2 CNTNAP3

3.19e-0432783PS51406
DomainPKD

SORCS3 SORCS1

3.57e-047782PF00801
DomainDesmosomal_cadherin

DSC2 DSC3

3.57e-047782IPR009122
DomainCadherin_pro

DSC2 DSC3

3.57e-047782PF08758
DomainHirudin/antistatin

MUC5AC ZFAND4

3.57e-047782IPR011061
DomainIGc2

IGSF10 FCRL3 FSTL5 ROR1 LILRB1 IGSF3

4.49e-04235786SM00408
DomainIg_sub2

IGSF10 FCRL3 FSTL5 ROR1 LILRB1 IGSF3

4.49e-04235786IPR003598
DomainEGF_CA

BMP1 MATN3 UMOD LTBP2

4.61e-0486784PF07645
DomainCadherin_pro_dom

DSC2 DSC3

4.74e-048782IPR014868
DomainCadherin_pro

DSC2 DSC3

4.74e-048782SM01055
DomainGrowth_fac_rcpt_

PCSK5 BMP1 MATN3 UMOD LTBP2

4.93e-04156785IPR009030
DomainPeptidase_S8_His-AS

PCSK5 TPP2

6.08e-049782IPR022398
DomainPeptidase_S8_Ser-AS

PCSK5 TPP2

6.08e-049782IPR023828
DomainSialidases

SORCS3 SORCS1

6.08e-049782IPR011040
DomainGalactose-bd-like

PCSK5 CNTNAP3B CNTNAP2 CNTNAP3

6.46e-0494784IPR008979
DomainPeptidase_S8_subtilisin-rel

PCSK5 TPP2

7.58e-0410782IPR015500
DomainSUBTILASE_ASP

PCSK5 TPP2

7.58e-0410782PS00136
DomainSUBTILASE_HIS

PCSK5 TPP2

7.58e-0410782PS00137
DomainSUBTILASE_SER

PCSK5 TPP2

7.58e-0410782PS00138
Domain-

PCSK5 TPP2

9.24e-04117823.40.50.200
DomainPeptidase_S8/S53_dom

PCSK5 TPP2

9.24e-0411782IPR000209
DomainPKD

SORCS3 SORCS1

9.24e-0411782PS50093
DomainPKD_dom

SORCS3 SORCS1

9.24e-0411782IPR000601
DomainPeptidase_S8

PCSK5 TPP2

9.24e-0411782PF00082
Domain-

SORCS3 SORCS1

9.24e-04117822.60.40.670
DomainTIL

FCGBP MUC5AC

1.11e-0312782PF01826
DomainC8

FCGBP MUC5AC

1.11e-0312782PF08742
DomainCUB

BMP1 CSMD1 CSMD2

1.12e-0349783PF00431
DomainCUB

BMP1 CSMD1 CSMD2

1.19e-0350783SM00042
DomainPeptidase_S1A

HPR LPA PLG CFB

1.28e-03113784IPR001314
DomainUnchr_dom_Cys-rich

FCGBP MUC5AC

1.30e-0313782IPR014853
DomainC8

FCGBP MUC5AC

1.30e-0313782SM00832
Domain-

BMP1 CSMD1 CSMD2

1.34e-03527832.60.120.290
DomainTRYPSIN_DOM

HPR LPA PLG CFB

1.37e-03115784PS50240
DomainCUB

BMP1 CSMD1 CSMD2

1.41e-0353783PS01180
DomainQuinoprotein_ADH-like_supfam

WDR7 EML1 WDR17

1.41e-0353783IPR011047
DomainTryp_SPc

HPR LPA PLG CFB

1.46e-03117784SM00020
DomainTIL_dom

FCGBP MUC5AC

1.52e-0314782IPR002919
DomainTrypsin

HPR LPA PLG CFB

1.65e-03121784PF00089
DomainTrypsin_dom

HPR LPA PLG CFB

1.65e-03121784IPR001254
DomainCUB_dom

BMP1 CSMD1 CSMD2

1.74e-0357783IPR000859
DomainN2O_reductase_N

EML1 WDR17

1.75e-0315782IPR011045
DomainPeptidase_S1_PA

HPR LPA PLG CFB

1.75e-03123784IPR009003
DomainVWD

FCGBP MUC5AC

1.99e-0316782SM00216
DomainVWF_type-D

FCGBP MUC5AC

1.99e-0316782IPR001846
DomainVWFD

FCGBP MUC5AC

1.99e-0316782PS51233
DomainVWD

FCGBP MUC5AC

1.99e-0316782PF00094
DomainConA-like_dom

CNTNAP3B FAT2 CNTNAP2 CNTNAP3 RYR2

2.23e-03219785IPR013320
DomainVWC_out

FCGBP MUC5AC

2.81e-0319782SM00215
DomainEF_HAND_2

FSTL5 CAPNS2 SMOC1 EFCAB7 RYR2

2.81e-03231785PS50222
DomainEF_hand_dom

FSTL5 CAPNS2 SMOC1 EFCAB7 RYR2

2.86e-03232785IPR002048
Domain-

PCSK5 CNTNAP2 CNTNAP3

3.53e-03737832.60.120.260
Domain-

MDN1 MATN3 CFB

3.67e-03747833.40.50.410
DomainKazal_1

FSTL5 SMOC1

3.77e-0322782PF00050
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

BMP1 LPA MATN3 CAPNS2 LTBP2 MMP2 PLG

5.39e-05258547MM14572
Pubmed

Skin wound healing in MMP2-deficient and MMP2 / plasminogen double-deficient mice.

LPA MMP2 PLG

1.22e-08381320163454
Pubmed

MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells.

LPA MMP2 PLG

1.21e-07581316147977
Pubmed

MT1-MMP-dependent neovessel formation within the confines of the three-dimensional extracellular matrix.

LPA MMP2 PLG

4.23e-07781315545316
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

CFH PCSK5 BMP1 SRPX2 HPR LTBP2 MMP2

1.91e-0624881724006456
Pubmed

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.

PCSK5 WDR7 ZFHX3 CSMD1

2.11e-063981419010793
Pubmed

Persistent corneal haze after excimer laser photokeratectomy in plasminogen-deficient mice.

LPA PLG

5.36e-06281210634603
Pubmed

Thrombomodulin functions as a plasminogen receptor to modulate angiogenesis.

LPA PLG

5.36e-06281223943648
Pubmed

Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.

LPA PLG

5.36e-0628127705657
Pubmed

Nucleocytoplasmic coagulation: an injury-induced aggregation event that disulfide crosslinks proteins and facilitates their removal by plasmin.

LPA PLG

5.36e-06281223041318
Pubmed

A novel role for plasmin-mediated degradation of opsonizing antibody in the evasion of host immunity by virulent, but not attenuated, Francisella tularensis.

LPA PLG

5.36e-06281219752236
Pubmed

SORCS1 and SORCS3 control energy balance and orexigenic peptide production.

SORCS3 SORCS1

5.36e-06281229440124
Pubmed

Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site.

LPA PLG

5.36e-0628126216475
Pubmed

Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus.

LPA PLG

5.36e-06281220440070
Pubmed

A central role for plasminogen in the inflammatory response to biomaterials.

LPA PLG

5.36e-06281215456492
Pubmed

Staphylococcus aureus manganese transport protein C (MntC) is an extracellular matrix- and plasminogen-binding protein.

LPA PLG

5.36e-06281225409527
Pubmed

Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen.

LPA PLG

5.36e-0628128704243
Pubmed

Plasmin promotes foam cell formation by increasing macrophage catabolism of aggregated low-density lipoprotein.

LPA PLG

5.36e-06281223702659
Pubmed

Oxidative stress and counteracting mechanisms in hormone receptor positive, triple-negative and basal-like breast carcinomas.

PRDX4 KEAP1

5.36e-06281221693047
Pubmed

Dengue virus-induced autoantibodies bind to plasminogen and enhance its activation.

LPA PLG

5.36e-06281222079981
Pubmed

Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task.

CNTNAP3B CNTNAP3

5.36e-06281226807827
Pubmed

Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice.

LPA PLG

5.36e-0628129490683
Pubmed

Kringle 5 of human plasminogen suppresses hepatocellular carcinoma growth both in grafted and xenografted mice by anti-angiogenic activity.

LPA PLG

5.36e-06281216481742
Pubmed

Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen: a novel mechanism for lipoprotein(a)-mediated inhibition of plasminogen activation.

LPA PLG

5.36e-06281218983515
Pubmed

Plasminogen Regulates Fracture Repair by Promoting the Functions of Periosteal Mesenchymal Progenitors.

LPA PLG

5.36e-06281234378815
Pubmed

Plasmin generation plays different roles in the formation and removal of arterial and venous thrombus in mice.

LPA PLG

5.36e-06281211848464
Pubmed

Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice.

LPA PLG

5.36e-0628127586361
Pubmed

Plasminogen/plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function.

LPA PLG

5.36e-06281221239499
Pubmed

Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice.

LPA PLG

5.36e-06281210642175
Pubmed

Plasminogen mRNA induction in the mouse brain after kainate excitation: codistribution with plasminogen activator inhibitor-2 (PAI-2) mRNA.

LPA PLG

5.36e-06281212225871
Pubmed

Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression.

LPA PLG

5.36e-06281237971174
Pubmed

The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis.

LPA PLG

5.36e-0628129884337
Pubmed

Colonic Lesions, Cytokine Profiles, and Gut Microbiota in Plasminogen-Deficient Mice.

LPA PLG

5.36e-06281226473342
Pubmed

Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death.

PTPN4 GRIN2A

5.36e-06281222000519
Pubmed

Selection of mutant µplasmin for amyloid-β cleavage in vivo.

LPA PLG

5.36e-06281232694536
Pubmed

Role of plasminogen in propagation of scrapie.

LPA PLG

5.36e-06281216103174
Pubmed

Loss of CSMD1 or 2 may contribute to the poor prognosis of colorectal cancer patients.

CSMD1 CSMD2

5.36e-06281224408017
Pubmed

Differential expression of oxidized/native lipoprotein(a) and plasminogen in human carotid and cerebral artery plaques.

LPA PLG

5.36e-06281221300353
Pubmed

Selective behaviors altered in plasminogen-deficient mice are reconstituted with intracerebroventricular injection of plasminogen.

LPA PLG

5.36e-06281211306011
Pubmed

Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression.

LPA PLG

5.36e-06281212149246
Pubmed

Protective effects of plasmin(ogen) in a mouse model of Staphylococcus aureus-induced arthritis.

LPA PLG

5.36e-06281218311818
Pubmed

Localization of plasminogen in mouse hippocampus, cerebral cortex, and hypothalamus.

LPA PLG

5.36e-06281221190118
Pubmed

A physiological function for apolipoprotein(a): a natural regulator of the inflammatory response.

LPA PLG

5.36e-06281218997104
Pubmed

Growth and behavioral development in plasminogen gene-targeted mice.

LPA PLG

5.36e-06281210885855
Pubmed

Cellular density regulation of plasminogen gene expression in mouse hepatocytes.

LPA PLG

5.36e-06281212559391
Pubmed

Plasminogen is a critical host pathogenicity factor for group A streptococcal infection.

LPA PLG

5.36e-06281215333838
Pubmed

Apo(a) promotes thrombosis in a vascular injury model by a mechanism independent of plasminogen.

LPA PLG

5.36e-06281216150044
Pubmed

Plasminogen has a broad extrahepatic distribution.

LPA PLG

5.36e-06281211916082
Pubmed

Delayed invasion of the kidney and brain by Borrelia crocidurae in plasminogen-deficient mice.

LPA PLG

5.36e-06281211500461
Pubmed

Role of plasminogen activation in neuronal organization and survival.

LPA PLG

5.36e-06281219683575
Pubmed

Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.

LPA PLG

5.36e-06281223555246
Pubmed

Binding of plasminogen to hepatocytes isolated from injured mouse liver and nonparenchymal-cell-dependent proliferation of hepatocytes.

LPA PLG

5.36e-06281218685433
Pubmed

Plasminogen mediates communication between the peripheral and central immune systems during systemic immune challenge with lipopolysaccharide.

LPA PLG

5.36e-06281231462325
Pubmed

Short-term inhibition of fibrinolytic system restores locomotor function after spinal cord injury in mice.

LPA PLG

5.36e-06281231690812
Pubmed

Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease.

LPA PLG

5.36e-06281230254165
Pubmed

Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice.

LPA PLG

5.36e-06281238328826
Pubmed

Reduced transplant arteriosclerosis in plasminogen-deficient mice.

LPA PLG

5.36e-0628129819364
Pubmed

Complement factor H is expressed in adipose tissue in association with insulin resistance.

CFH CFB

5.36e-06281219833879
Pubmed

The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice.

CNTNAP3B CNTNAP3

5.36e-06281231150793
Pubmed

In vivo plasminogen deficiency reduces fat accumulation.

LPA PLG

5.36e-06281212083480
Pubmed

Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice.

LPA PLG

5.36e-06281218420257
Pubmed

Plasminogen alleles influence susceptibility to invasive aspergillosis.

LPA PLG

5.36e-06281218566672
Pubmed

The generation and characterization of mice expressing a plasmin-inactivating active site mutation.

LPA PLG

5.36e-06281220653841
Pubmed

Influence of plasminogen deficiency on the contribution of polymorphonuclear leucocytes to fibrin/ogenolysis: studies in plasminogen knock-out mice.

LPA PLG

5.36e-06281212428098
Pubmed

Plasminogen deficiency causes reduced corticospinal axonal plasticity and functional recovery after stroke in mice.

LPA PLG

5.36e-06281224732409
Pubmed

Plasminogen promotes macrophage phagocytosis in mice.

LPA PLG

5.36e-06281224876560
Pubmed

Plasminogen is a joint-specific positive or negative determinant of arthritis pathogenesis in mice.

LPA PLG

5.36e-06281224574269
Pubmed

Spontaneous development of otitis media in plasminogen-deficient mice.

LPA PLG

5.36e-06281216956791
Pubmed

The mouse plasminogen locus maps to the recombination breakpoints of the tLub2 and TtOrl partial t haplotypes but is not at the tw73 locus.

LPA PLG

5.36e-0628121543918
Pubmed

Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals.

LPA PLG

5.36e-06281217267741
Pubmed

Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen on the surface of vascular endothelial and smooth muscle cells.

LPA PLG

5.36e-06281229990619
Pubmed

Reduction of experimental diabetic vascular leakage by delivery of angiostatin with a recombinant adeno-associated virus vector.

LPA PLG

5.36e-06281217293777
Pubmed

Plasminogen plays a crucial role in bone repair.

LPA PLG

5.36e-06281223456978
Pubmed

Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction.

LPA PLG

5.36e-06281210854210
Pubmed

Gender affects skin wound healing in plasminogen deficient mice.

LPA PLG

5.36e-06281223527289
Pubmed

Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice.

LPA PLG

5.36e-0628129770530
Pubmed

A genetic association study of CSMD1 and CSMD2 with cognitive function.

CSMD1 CSMD2

5.36e-06281227890662
Pubmed

Plasminogen activation is required for the development of radiation-induced dermatitis.

LPA PLG

5.36e-06281230323258
Pubmed

Subcellular localization of ATBF1 regulates MUC5AC transcription in gastric cancer.

ZFHX3 MUC5AC

5.36e-06281217330845
Pubmed

Nonfibrinolytic functions of plasminogen.

LPA PLG

5.36e-06281210816371
Pubmed

Plasminogen is a critical regulator of cutaneous wound healing.

LPA PLG

5.36e-06281226791370
Pubmed

Identification and characterization of SorCS, a third member of a novel receptor family.

SORCS3 SORCS1

5.36e-06281210600506
Pubmed

Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.

LPA PLG

5.36e-0628127525077
Pubmed

The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia.

CSMD1 CSMD2

5.36e-06281221439553
Pubmed

Contrasting roles of plasminogen deficiency in different rheumatoid arthritis models.

LPA PLG

5.36e-06281216052596
Pubmed

Functional corpora lutea are formed in matrix metalloproteinase inhibitor-treated plasminogen-deficient mice.

LPA PLG

5.36e-06281217122079
Pubmed

Beta-amyloid (Abeta) causes detachment of N1E-115 neuroblastoma cells by acting as a scaffold for cell-associated plasminogen activation.

LPA PLG

5.36e-06281215737740
Pubmed

Plasminogen deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis.

LPA PLG

5.36e-06281222056679
Pubmed

The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain.

LPA PLG

5.36e-06281218039665
Pubmed

Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice.

LPA PLG

5.36e-0628129671388
Pubmed

A Novel Complotype Combination Associates with Age-Related Macular Degeneration and High Complement Activation Levels in vivo.

CFH CFB

5.36e-06281227241480
Pubmed

Physiologic variations in blood plasminogen levels affect outcomes after acute cerebral thromboembolism in mice: a pathophysiologic role for microvascular thrombosis.

LPA PLG

5.36e-06281227319402
Pubmed

Lipid rafts regulate PCB153-induced disruption of occludin and brain endothelial barrier function through protein phosphatase 2A and matrix metalloproteinase-2.

MMP2 OCLN

5.36e-06281226080028
Pubmed

Unaltered prion protein cleavage in plasminogen-deficient mice.

LPA PLG

5.36e-06281216543819
Pubmed

Association of CFH and CFB gene polymorphisms with retinopathy in type 2 diabetic patients.

CFH CFB

5.36e-06281223864767
Pubmed

Essential role of DNA-PKcs and plasminogen for the development of doxorubicin-induced glomerular injury in mice.

LPA PLG

5.36e-06281234423816
Pubmed

Growth of human squamous cell carcinoma xenografts in mice is inhibited by local angiostatin gene therapy.

LPA PLG

5.36e-06281212167431
Pubmed

Impaired wound healing in mice with a disrupted plasminogen gene.

LPA PLG

5.36e-0628128612226
Pubmed

Ovulation in plasminogen-deficient mice.

LPA PLG

5.36e-06281210537128
Pubmed

Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis.

LPA PLG

5.36e-0628129242524
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

DPP7 CFH DPEP1 FCGBP ARSB DSC2 HPR PEPD UMOD LTBP2 PLG CFB

6.78e-061070811223533145
InteractionGNG8 interactions

CFH FCGBP HPR EXOG PLG MUC5AC CFB

6.51e-07125807int:GNG8
InteractionSLURP1 interactions

PCSK5 BMP1 CNTNAP3B ARSB DSC2 CNTNAP3 SMOC1

1.69e-06144807int:SLURP1
InteractionEDDM3A interactions

ARSB DSC2 CNTNAP3 EDDM3A

1.38e-0537804int:EDDM3A
InteractionPHF11 interactions

CFH FCGBP HPR CASP6 PLG CFB

1.76e-05137806int:PHF11
InteractionDEFA1 interactions

BMP1 ARSB CNTNAP3 SMOC1 IGSF3

4.87e-05100805int:DEFA1
Cytoband10q23-q25

SORCS3 SORCS1

1.84e-05481210q23-q25
CytobandEnsembl 112 genes in cytogenetic band chr6q26

LPA PLG

3.63e-0416812chr6q26
Cytoband6q26

LPA PLG

4.62e-04188126q26
Cytoband18q12.1

DSC2 DSC3

9.72e-042681218q12.1
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

CFH SRPX2 HPR CSMD1 CSMD2 CFB

2.15e-08575661179
GeneFamilyDesmosomal cadherins

DSC2 DSC3

1.96e-0475621188
CoexpressionKIM_GLIS2_TARGETS_UP

CFH IGSF10 HLA-DRB5 LTBP2 LILRB1

1.64e-05102815MM1064
CoexpressionGSE36826_NORMAL_VS_STAPH_AUREUS_INF_IL1R_KO_SKIN_UP

BLVRB FCGBP DSC2 WDR7 PEPD CASP6

3.59e-05199816M9531
CoexpressionGSE1432_CTRL_VS_IFNG_24H_MICROGLIA_UP

PASK ROR1 ZFHX3 LTBP2 ABCG2 MMP2

3.69e-05200816M3407
CoexpressionGSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_DN

BLVRB PCSK5 FCGBP DSC2 WDR7 CASP6

3.69e-05200816M9535
CoexpressionAtlasStromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4

CFH IGSF10 DPEP1 BMP1 SRPX2 DSC2 DSC3 LTBP2 MMP2 CSMD1 CFB

1.07e-064558011GSM777055_500
CoexpressionAtlasStromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5

CFH IGSF10 DPEP1 BMP1 SRPX2 DSC2 DSC3 MMP2 CSMD1 CFB TMED3

1.36e-064668011GSM777050_500
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_top-relative-expression-ranked_500

CFH IGSF10 PTPN4 DSC2 CASP6 MMP2 SMOC1 RYR2

5.97e-05357808gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#2_top-relative-expression-ranked_1000

DSC2 DSC3 PCDHB12 ZFHX3 SLC2A13 ZFAND4 IGSF3 SORCS1

8.72e-05377808gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000_k2
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_top-relative-expression-ranked_1000

CFH IGSF10 BMP1 PTPN4 DSC2 CASP6 MMP2 SMOC1 PCMTD1 RYR2 AKAP7

1.00e-047408011gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_1000
CoexpressionAtlasDevelopingKidney_e15.5_early proxim tubul_emap-28005_k-means-cluster#4_top-relative-expression-ranked_200

DPEP1 NR1H4 CFB

1.12e-0425803gudmap_developingKidney_e15.5_early proxim tubul_200_k4
CoexpressionAtlasMESO-30 blastocyst_vs_MESO-30 amniotic fluid MSC-Confounder_removed-fold2.0_adjp0.05

BLVRB PCSK5 SRPX2 MATN3 SYNGR2 LTBP2 MMP2 PLG OCLN CFB AKAP7

1.28e-047618011PCBC_ratio_MESO-30 blastocyst_vs_MESO-30 amniotic fluid MSC_cfr-2X-p05
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_top-relative-expression-ranked_1000

DSC2 DSC3 PCDHB12 ZFHX3 SLC2A13 PLG CTNND2 PCMTD1 ZFAND4 IGSF3 SORCS1

1.41e-047698011gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

FSTL5 CNTNAP2 GRIN2A CTNND2 CSMD1 CSMD2 RYR2

9.33e-09146817c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCellMesenchymal_cells-Adipo-CAR|World / Lineage and Cell class

CFH DPEP1 LTBP2 SMOC1 CSMD1 CFB IGSF3

4.95e-081868176ca8ce7ced91d6308b7c056032ffec1b37c974bf
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFH IGSF10 DPEP1 MMP2 SMOC1 CFB IGSF3

5.93e-081918172b73fcd592d16cae8ded5e45c8fbf2d9adc8caad
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFH IGSF10 DPEP1 MMP2 SMOC1 CFB IGSF3

6.15e-08192817011634a24b0c61d9b463fe755502edbc5cd70b7a
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Mesenchymal-mesenchymal_stem_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH IGSF10 DPEP1 BMP1 SRPX2 MMP2 TMED3

6.37e-08193817160691b671710be10220803d788c2c961c236af1
ToppCellLA-02._Fibroblast_II|LA / Chamber and Cluster_Paper

CFH PCSK5 SRPX2 ZFHX3 LTBP2 SLC2A13 SORCS1

6.60e-08194817234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo4_Rxfp1_Chat|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FSTL5 CNTNAP2 SORCS3 SLC2A13 IGSF3 SORCS1

3.98e-071558163b8def9e8f66511736ea37f259511f7c8b7743af
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

FSTL5 CNTNAP2 CTNND2 CSMD1 CSMD2 RYR2

4.62e-071598165335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCelldroplet-Heart-nan-18m-Mesenchymal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH DPEP1 PCDHB5 ROR1 RAVER2 IGSF3

5.95e-071668169adceb746e67e955fd8b3e0984f4eed44b64a270
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FSTL5 CNTNAP2 CTNND2 CSMD1 CSMD2 SORCS1

6.16e-071678163edb0570e583bb527165bcd8a4c25a042054043b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH PCSK5 DSC3 LTBP2 MMP2 SMOC1

6.38e-071688164b2d29a7843bf45922038c093ca7ec0600756adc
ToppCellRA-01._Fibroblast_I|RA / Chamber and Cluster_Paper

CFH SRPX2 MATN3 ZFHX3 SLC2A13 SORCS1

6.60e-071698166373562ab3b1765060212a6a53d6543e7e942e80
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFH DPEP1 MMP2 PLG CFB IGSF3

6.60e-07169816031465190cd3623a25ef2b868daab8d932c8ff08
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH PCSK5 DSC3 LTBP2 MMP2 SMOC1

7.08e-071718165d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCellASK440-Epithelial-Transformed_epithelium|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

MATN3 SELENOO CNTNAP3 LTBP2 MMP2 IGSF3

7.32e-07172816df3800bcd9777d02900eba0cfc26ab73de8a1d95
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FSTL5 CNTNAP2 SORCS3 SLC2A13 IGSF3 SORCS1

7.32e-071728167e1a7700a4c2b1d100da1d6e475e73498ebb605a
ToppCellASK440-Epithelial-Transformed_epithelium|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

MATN3 SELENOO CNTNAP3 LTBP2 MMP2 IGSF3

8.94e-0717881686f1741636ed3e85bb4a65f84949b718fc38c290
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CNTNAP3B CCM2L CNTNAP3 ABCG2 RPGR EML1

9.54e-0718081627e8bbee388e64dd79d70b160b76d45b1f398006
ToppCellfacs-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH IGSF10 PCSK5 DPEP1 SRPX2 MMP2

9.86e-07181816269b39ac65790061d54eab47a8eeb024403f0348
ToppCellfacs-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH IGSF10 PCSK5 DPEP1 SRPX2 MMP2

9.86e-07181816cd4f744b6b64ba6c22ec07afd1d3058a2546909d
ToppCellfacs-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH IGSF10 PCSK5 DPEP1 SRPX2 MMP2

9.86e-07181816c8395ae872aa80b3ae1ab7c53e57b3ca15aeb0e2
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

CNTNAP2 UMOD LTBP2 GRIN2A CSMD1 RYR2

9.86e-07181816c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 ARSB ROR1 LTBP2 RYR2 SORCS1

1.05e-061838167eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCellfacs-Liver-Hepatocytes-24m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP1 DSC2 PLG SMOC1 OCLN CFB

1.05e-06183816d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCellCOVID-19-kidney-PCT-S1/S2|kidney / Disease (COVID-19 only), tissue and cell type

PCSK5 CNTNAP3B ROR1 PEPD PLG SORCS1

1.08e-06184816dc71f22583fc54b89b242cbb602f4bbe86f576ec
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CFH ZFHX3 LTBP2 MMP2 CSMD1 RYR2

1.12e-061858167dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFH IGSF10 CNTNAP2 LTBP2 MMP2 SMOC1

1.16e-061868164e983de6d2515082f9e555f4f949cec84281c140
ToppCellfacs-Pancreas-Exocrine-24m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH IGSF10 DPEP1 SRPX2 UMOD MMP2

1.19e-061878160f90bce2087aecfdbb377e6f46c6e468efbb6e28
ToppCellfacs-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH IGSF10 DPEP1 SRPX2 UMOD MMP2

1.19e-0618781676c957b2976d38adb45e07bcf96c689442e1fc20
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 DPEP1 CNTNAP3B PEPD PLG SORCS1

1.19e-06187816dcf6475ece5b34d9d58a0d1f51c18acedb19c119
ToppCellfacs-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH IGSF10 DPEP1 SRPX2 UMOD MMP2

1.19e-0618781690a1078b0303799fba5d2ca4fa12076fd75b78b1
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 DPEP1 CNTNAP3B PEPD PLG SORCS1

1.19e-06187816f1356273bd3587b6883295edf15cb9cdb706c057
ToppCellCOVID-19-kidney-Stressed_PCT|kidney / Disease (COVID-19 only), tissue and cell type

PCSK5 CNTNAP3B ROR1 PEPD PLG SORCS1

1.19e-06187816acd305475f3609800af0d7bc68d83ef41228080b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DPEP1 CNTNAP3B ARSB PEPD PLG SORCS1

1.23e-06188816f3edcefeef2ce19086032d98b243c02a6d542b38
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DPEP1 CNTNAP3B ARSB PEPD PLG SORCS1

1.23e-061888160792432cd4c564dea1102241ea9884f7ced7658c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DPEP1 CNTNAP3B ARSB PEPD PLG SORCS1

1.27e-06189816204ab61ae606b2d9be0cb6bf6a83a011740693a8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DPEP1 CNTNAP3B ARSB PEPD PLG SORCS1

1.27e-0618981613fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCell(1)_Osterolineage_cells-(10)_OLC-1|World / Cell class and subclass of bone marrow stroma cells in homeostatis

CFH NHSL1 BMP1 SRPX2 MMP2 IGSF3

1.27e-0618981646c5b975fb9d33017f2d9b7770d45a8bdf95baa2
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Mgp_(Mgp)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SRPX2 ABL2 MATN3 LTBP2 NR1H4

1.27e-0610381539d8cfb899ca88c72ebe021d66cc21ae2eb6a1cc
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Mgp_(Mgp)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SRPX2 ABL2 MATN3 LTBP2 NR1H4

1.27e-0610381501a7baaa0c3903bd00e37717856d2c1ac21bf2c8
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CFH DPEP1 CCM2L MATN3 ABCG2 RPGR

1.31e-0619081606bfb62b94b0faf467ef93d5bc5d08924c770098
ToppCellMonocytes-Tissue-resident_macrophages|World / Immune cells in Kidney/Urine in Lupus Nephritis

NHSL1 FCGBP DSC2 HLA-DRB5 ZFHX3 MMP2

1.31e-0619081607215e8f292cb54c670037aaf28393cddbe5548c
ToppCellASK454-Mesenchymal|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

CFH PCSK5 PCDHB12 LTBP2 MMP2 RYR2

1.35e-06191816e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCellASK454-Mesenchymal-Fibroblast|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

CFH PCSK5 PCDHB12 LTBP2 MMP2 RYR2

1.35e-061918161726add3f392a061536b7aff72ba84303f4a0b1f
ToppCelldroplet-Kidney-nan-18m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH IGSF10 SRPX2 LTBP2 MMP2 CSMD1

1.39e-0619281638d7a24ae205ef91ed2e0f402d8022f2a9cdb243
ToppCellfacs-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH IGSF10 DPEP1 BMP1 MMP2 CFB

1.39e-06192816a2c31390da4962bda9a936470b0b68fa1f5d47d1
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFH DPEP1 BMP1 MMP2 CFB TMED3

1.39e-061928160e7e55505bd5454d7cf952a63fdcb46ec76f1973
ToppCelldroplet-Kidney-nan-18m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH IGSF10 SRPX2 LTBP2 MMP2 CSMD1

1.39e-0619281604d155897ed075c359933080e36a4ab2150b6e9f
ToppCellfacs-Lung-nan-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH IGSF10 DPEP1 BMP1 MMP2 CFB

1.39e-06192816eeab1cef7c36ae824381952c5b2c982368c379fd
ToppCelldroplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFH IGSF10 DPEP1 ROR1 MMP2 IGSF3

1.39e-061928161b228f0929b505de82a39bf64c837887b0e56701
ToppCelldroplet-Kidney-nan-18m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH IGSF10 SRPX2 LTBP2 MMP2 CSMD1

1.39e-0619281684149a5c6c3b3c9b86aed77cf8e72d99ef099fab
ToppCellfacs-Lung-EPCAM-18m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH DPEP1 MMP2 SMOC1 CFB IGSF3

1.43e-0619381692048d2e9e43513e6185e09553be3ee47d7e5207
ToppCellfacs-MAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH IGSF10 PCSK5 DPEP1 BMP1 MMP2

1.43e-06193816f95b95c58a6edb8a03dd15ae166f47f9f33d8bd6
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFH IGSF10 DPEP1 MMP2 CFB IGSF3

1.43e-06193816e27885a9e1a2a3e165c5366d4cfcda05c5454483
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFH DPEP1 BMP1 MMP2 CFB TMED3

1.43e-06193816025836c5c5a711e477c326559e618e47cae42d11
ToppCelldistal-Hematologic-IGSF21+_Dendritic-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

BLVRB FCGBP DSC2 HLA-DRB5 ZFHX3 LTBP2

1.43e-0619381648ce11778252ae2ef902b30816061b59a3c81695
ToppCellfacs-Lung-EPCAM-18m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH DPEP1 MMP2 SMOC1 CFB IGSF3

1.43e-06193816ac088c8f27b5b1888610e461ff45870ca60da886
ToppCellfacs-MAT-Fat-3m-Mesenchymal-mesenchymal_progenitor|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH IGSF10 PCSK5 DPEP1 BMP1 MMP2

1.43e-0619381685faf6c5ce4769615a4eca036e2ba307e176bb52
ToppCellfacs-MAT-Fat-3m-Mesenchymal|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH IGSF10 PCSK5 DPEP1 BMP1 MMP2

1.43e-06193816110a7d2ba7d066c2be38be98b643b76c520dd980
ToppCellLV-02._Fibroblast_II|LV / Chamber and Cluster_Paper

CFH PCSK5 SRPX2 ZFHX3 LTBP2 SLC2A13

1.48e-06194816014d2feb5db2a6a35ef759761a41e466e108c3c1
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFH IGSF10 DPEP1 MMP2 CFB IGSF3

1.48e-06194816c9e589fe7df6a9b377654581a2aebb607cbb03b9
ToppCellfacs-GAT-Fat-3m-Mesenchymal-mesenchymal_progenitor|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH IGSF10 PCSK5 DPEP1 BMP1 MMP2

1.52e-0619581669a29d03e664b72f32d41876510c62345c3aed31
ToppCellfacs-GAT-Fat-3m-Mesenchymal|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH IGSF10 PCSK5 DPEP1 BMP1 MMP2

1.52e-061958161cffae2b08dbfa1c633ce24023e89b66d28b5431
ToppCellfacs-GAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH IGSF10 PCSK5 DPEP1 BMP1 MMP2

1.52e-061958169cef6f18664518060af7c192310dddce6d70345a
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Il33_(Il33)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

SRPX2 ABL2 MATN3 LTBP2 NR1H4

1.54e-06107815d446ffbe93cd49669f1cf91411aae07cc15d9e2a
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Il33_(Il33)|Hippocampus / BrainAtlas - Mouse McCarroll V32

SRPX2 ABL2 MATN3 LTBP2 NR1H4

1.54e-061078155c9e745d0b08a4aa1f3a93f9cc094fac57061a30
ToppCellfacs-Thymus-Thymus_Epithelium|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH IGSF10 PCSK5 MMP2 CSMD1 CFB

1.57e-061968166bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCellfacs-Thymus-Thymus_Epithelium-18m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH IGSF10 PCSK5 MMP2 CSMD1 CFB

1.57e-06196816c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCellIPF-Stromal-Myofibroblast|World / Disease state, Lineage and Cell class

CFH SRPX2 ROR1 LTBP2 MMP2 RYR2

1.57e-061968167fc9894ceb79dab9f0495acc84e2d6d0d1c69bb7
ToppCellIPF-Stromal-Myofibroblast|IPF / Disease state, Lineage and Cell class

CFH SRPX2 ROR1 LTBP2 MMP2 RYR2

1.57e-061968162d0a48e49b3b37bb66e33e74c52915911e1f8a74
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CFH DPEP1 CCM2L MATN3 ABCG2 OCLN

1.57e-06196816889c9fed857f64664ca1f47fcec9fecb15ed103c
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CFH DPEP1 CCM2L MATN3 ABCG2 RPGR

1.57e-06196816ed818de15f84f7f28bd06fd69d7876710da232a0
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CFH DPEP1 CCM2L MATN3 ABCG2 OCLN

1.61e-06197816e567f91fa398fd306d025dcfe89bd50a60216537
ToppCellCOVID-19-Fibroblasts-Intermediate_pathological_FB|COVID-19 / group, cell type (main and fine annotations)

CFH ROR1 LTBP2 MMP2 CSMD2 RYR2

1.61e-06197816f1c8936986123a3151140c374fcd62d6705c530b
ToppCellmLN-(2)_B_cell-(20)_B_cell_IgA_Plasma|mLN / shred on region, Cell_type, and subtype

DPEP1 SRPX2 PRDX4 CTNND2 SMOC1 CEP170B

1.61e-06197816a39b384ee9824a08c3b544a9c3c7f0f95f08d6a7
ToppCellCOVID-19-Fibroblasts|COVID-19 / group, cell type (main and fine annotations)

CFH ROR1 LTBP2 MMP2 CSMD2 RYR2

1.61e-06197816fb847f2277609c31fffcdf49517243ce0684facf
ToppCellmLN-B_cell-B_cell_IgA_Plasma|mLN / Region, Cell class and subclass

DPEP1 SRPX2 PRDX4 CTNND2 SMOC1 CEP170B

1.61e-0619781620822fce311326765b71337ce501ba44ea14f58f
ToppCellParenchymal-10x3prime_v2-Stromal-Mesofibroblastic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CFH DSC3 PCDHB12 LTBP2 MMP2 CSMD2

1.66e-061988160cd930e374c2c48d1991b51c025f9801b22ecee7
ToppCellIPF-Stromal|IPF / Disease state, Lineage and Cell class

CFH SRPX2 ROR1 LTBP2 MMP2 RYR2

1.66e-06198816ece914c32c9b123b779aa9624b92e6230763a20e
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CFH IGSF10 SRPX2 LTBP2 MMP2 RYR2

1.66e-06198816f1374f7a50244d59c766ac41f44c08c9117407d2
ToppCellParenchymal-10x3prime_v2-Stromal-Mesofibroblastic-Mesothelia|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CFH DSC3 PCDHB12 LTBP2 MMP2 CSMD2

1.66e-06198816e0df6d6ff2a9c41d813f84a2a5ee7cb5f6fc3e30
ToppCelldistal-mesenchymal-Alveolar_Fibroblast-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CFH IGSF10 SRPX2 PCDHB5 LTBP2 MMP2

1.71e-0619981628c1722deef3b8347371c7359be7c64b95780de3
ToppCellBiopsy_Control_(H.)-Epithelial-Basal|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

CFH FAT2 DSC3 FSTL5 CNTNAP2 CAPNS2

1.71e-061998166a274a5db02c55bbf31d602b9d5c8394241acdca
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_2|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CFH IGSF10 SRPX2 LTBP2 MMP2 RYR2

1.71e-0619981666a79732caf2f04c09b4d9832377aa01ca477677
ToppCell343B-Fibroblasts-Fibroblast-G|343B / Donor, Lineage, Cell class and subclass (all cells)

CFH IGSF10 SRPX2 LTBP2 MMP2 RYR2

1.71e-06199816f4b6c095cbe7a38b310adc49be4069e4d56e6a66
ToppCell343B-Fibroblasts-Fibroblast-G-|343B / Donor, Lineage, Cell class and subclass (all cells)

CFH IGSF10 SRPX2 LTBP2 MMP2 RYR2

1.71e-061998169c6d1c328bfbb6547f4c7bb2a784576a56bd72af
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

SORCS3 SLC2A13 SMOC1 CSMD1 CSMD2 SORCS1

1.76e-06200816f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

SORCS3 SLC2A13 SMOC1 CSMD1 CSMD2 SORCS1

1.76e-06200816cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellParenchymal-10x5prime-Stromal-Fibroblastic-Fibro_alveolar|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFH IGSF10 SRPX2 LTBP2 MMP2 RYR2

1.76e-062008168c62f05c6042f24287a73fbdf80ff4a56f7ff403
ToppCellParenchyma_Control_(B.)-Stromal-TX-Fibroblasts-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

CFH IGSF10 SRPX2 LTBP2 MMP2 RYR2

1.76e-06200816aa1a35dcca3b799241eef4237f6eb94660e019f0
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

SORCS3 SLC2A13 SMOC1 CSMD1 CSMD2 SORCS1

1.76e-06200816c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CFH IGSF10 SRPX2 LTBP2 MMP2 RYR2

1.76e-06200816a510deaada669e690329183e18df02870bd204b3
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

SORCS3 SLC2A13 SMOC1 CSMD1 CSMD2 SORCS1

1.76e-062008164fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CFH DPEP1 CCM2L MATN3 ABCG2 RPGR

1.76e-06200816c239e6f5d23caa9a59b83e9b352b2d6a691dcb28
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

SORCS3 SLC2A13 SMOC1 CSMD1 CSMD2 SORCS1

1.76e-06200816310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CFH DPEP1 CCM2L MATN3 ABCG2 RPGR

1.76e-06200816061ba851f941c616ddb462512e826c412881c3ce
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

SORCS3 SLC2A13 SMOC1 CSMD1 CSMD2 SORCS1

1.76e-06200816961858738ce35db8760c8c2e136f8369bc444ccf
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CFH IGSF10 SRPX2 LTBP2 MMP2 RYR2

1.76e-06200816dd4228cbed8a4395166a6332e08d44d88bebe3b9
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Hippocampus / BrainAtlas - Mouse McCarroll V32

SRPX2 ABL2 MATN3 LTBP2 NR1H4

4.65e-06134815b959899c89d3a0363a3cd2309155280e0fe5ba88
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

FSTL5 CNTNAP2 SORCS3 GRIN2A SORCS1

5.56e-06139815a1945b07f177cde40e7eea03a19236ce76165857
ComputationalGenes in the cancer module 107.

BMP1 PEPD MMP2 PLG CFB

4.50e-0579545MODULE_107
ComputationalCatabolic peptidases.

BMP1 PEPD MMP2 PLG CFB

7.98e-0589545MODULE_209
ComputationalGenes in the cancer module 172.

BMP1 PEPD MMP2 PLG CFB

1.14e-0496545MODULE_172
ComputationalMMPs.

BMP1 PEPD MMP2

1.50e-0421543MODULE_562
ComputationalHeart, liver, kidney and pancreas metabolic and xenobiotic response genes.

CFH BLVRB BMP1 FAT2 FCGBP WDR7 HPR PEPD UMOD MMP2 PLG OCLN CFB

1.90e-048355413MODULE_88
ComputationalGenes in the cancer module 55.

CFH BLVRB BMP1 FAT2 WDR7 HPR PEPD UMOD MMP2 PLG OCLN CFB

7.03e-048325412MODULE_55
DrugPHA-00851261E [724719-49-7]; Down 200; 1uM; PC3; HT_HG-U133A

BMP1 PASK DSC2 EXOG MMP2 CTNND2 RYR2

5.88e-061968073776_DN
DrugLynestrenol [52-76-6]; Down 200; 14uM; MCF7; HT_HG-U133A

BMP1 PASK ARSB DSC2 EML1 RYR2 AKAP7

6.28e-061988071537_DN
DrugFonofos

FCGBP DSC3 LPA MATN3 FSTL5 ROR1 CNTNAP2 ZFHX3 SLC2A13 CTNND2 CFB RYR2

7.05e-067148012ctd:D004397
Drugterbufos

FCGBP DSC3 LPA MATN3 FSTL5 ROR1 CNTNAP2 ZFHX3 SLC2A13 CTNND2 CFB RYR2

8.12e-067248012ctd:C012568
DrugVanadates

DPP7 SRPX2 ARSB DSC2 DSC3 ROR1 SYNGR2 RAVER2 PCDHB12 ZFHX3 LTBP2 ABCG2 MMP2 PCMTD1 WDR17 ZFAND4

9.97e-0613028016ctd:D014638
Drugalbendazole sulfoxide

ABCG2 NR1H4

1.22e-052802ctd:C027186
Diseaseautosomal recessive intellectual developmental disorder (implicated_via_orthology)

CNTNAP3B CNTNAP2 CNTNAP3

9.86e-078783DOID:0060308 (implicated_via_orthology)
Diseasemonokine induced by gamma interferon measurement

LPA FSTL5 PLG SMOC1

1.11e-0552784EFO_0008236
DiseaseHepatomegaly

CRYGD PEPD KEAP1 NR1H4

1.29e-0554784C0019209
Diseasecomplement C3D fragment measurement

CFH CFB

2.07e-053782EFO_0020277
DiseaseEpilepsy, Rolandic

SRPX2 GRIN2A

2.07e-053782C0376532
Diseasecysteine and glycine-rich protein 2 measurement

CFH CFB

2.07e-053782EFO_0802444
Diseaseneurogenic locus notch homolog protein 2 measurement

CFH NBPF10

2.07e-053782EFO_0020599
DiseaseBenign Rolandic Epilepsy

SRPX2 GRIN2A

2.07e-053782C2363129
Diseasesorting nexin-7 measurement

CFH CFB

4.12e-054782EFO_0803094
Diseaseuromodulin measurement

CFH TSBP1 UMOD

4.42e-0526783EFO_0021778
Diseasemacular degeneration (is_implicated_in)

CFH MMP2 CFB

4.97e-0527783DOID:4448 (is_implicated_in)
DiseaseAge related macular degeneration

CFH RPGR CFB

6.85e-0530783C0242383
Diseasechronic kidney disease, APOL1 risk genotype carrier status

LPA PLG

6.86e-055782EFO_0003884, EFO_0009324
Diseasearrhythmogenic right ventricular cardiomyopathy (implicated_via_orthology)

DSC2 DSC3

6.86e-055782DOID:0050431 (implicated_via_orthology)
Diseasedesmocollin-2 measurement

DSC2 DSC3

6.86e-055782EFO_0021936
Diseaseplasma plasminogen measurement

LPA PLG

6.86e-055782EFO_0006309
Diseasemucinous adenocarcinoma (is_marker_for)

ZFHX3 MUC5AC

6.86e-055782DOID:3030 (is_marker_for)
Diseasesynaptotagmin-like protein 4 measurement

CFH SRPX2

6.86e-055782EFO_0802109
Diseaseinterleukin-10 receptor subunit beta measurement

CFH CFB

6.86e-055782EFO_0020489
Diseasehyperuricemia

DPEP1 UMOD ABCG2

9.16e-0533783EFO_0009104
Diseaseaurora kinase B measurement

CFH CFB

1.03e-046782EFO_0020169
DiseaseDNA-binding protein SATB2 measurement

CFH CFB

1.03e-046782EFO_0802484
Diseasethymidine kinase, cytosolic measurement

CFH CFB

1.03e-046782EFO_0020773
DiseaseNKG2-E type II integral membrane protein measurement

CFH CFB

1.03e-046782EFO_0801842
Diseasetranscription factor AP-1 measurement

CFH CFB

1.03e-046782EFO_0021909
DiseaseCCAAT/enhancer-binding protein beta measurement

CFH CFB

1.03e-046782EFO_0021905
Diseaseangiostatin measurement

LPA PLG

1.03e-046782EFO_0008024
Diseaselow density lipoprotein cholesterol measurement, alcohol consumption measurement

PCSK5 HPR LPA PLG

1.41e-0499784EFO_0004611, EFO_0007878
Diseasetriglyceride measurement, alcohol drinking

HPR LPA PEPD PLG

1.41e-0499784EFO_0004329, EFO_0004530
Diseasemast/stem cell growth factor receptor kit measurement

CFH CFB

1.44e-047782EFO_0020554
DiseaseGlomerulonephritis, Membranoproliferative

CFH CFB

1.44e-047782C0017662
Diseaselipoprotein A measurement, apolipoprotein A 1 measurement

LPA PLG

1.44e-047782EFO_0004614, EFO_0006925
Diseasetriglyceride measurement, alcohol consumption measurement

HPR LPA PEPD PLG

1.52e-04101784EFO_0004530, EFO_0007878
Diseaselow density lipoprotein cholesterol measurement, alcohol drinking

PCSK5 HPR LPA PLG

1.58e-04102784EFO_0004329, EFO_0004611
Diseaselipoprotein-associated phospholipase A(2) measurement

LPA ABCG2 PLG

1.64e-0440783EFO_0004746
Diseaseclinical treatment

SORCS3 PLG NR1H4

1.76e-0441783EFO_0007056
Diseaseanterior uveitis (is_implicated_in)

CFH CFB

1.91e-048782DOID:1407 (is_implicated_in)
DiseasePH and SEC7 domain-containing protein 1 measurement

CFH CFB

1.91e-048782EFO_0803302
Diseaseatypical hemolytic-uremic syndrome (is_implicated_in)

CFH CFB

1.91e-048782DOID:0080301 (is_implicated_in)
Diseasecomplement C1q and tumor necrosis factor-related protein 9A measurement

CFH CFB

2.45e-049782EFO_0803293
DiseaseAtypical hemolytic-uremic syndrome

CFH CFB

2.45e-049782cv:C2931788
Diseasebringing up phlegm, sputum or mucus on most days, self-reported

HLA-DRB5 MUC5AC

2.45e-049782EFO_0009824
Diseasetumor necrosis factor ligand superfamily member 14 measurement

CFH CFB

2.45e-049782EFO_0010613
DiseaseC3 glomerulopathy

CFH CFB

2.45e-049782C4087273
DiseaseHemolytic-uremic syndrome

CFH CFB

2.45e-049782cv:C0019061
Diseasecomplement factor B measurement

CFH CFB

2.45e-049782EFO_0008096
DiseaseHLA class II histocompatibility antigen, DQ alpha 2 chain measurement

CFH HLA-DRB5

2.45e-049782EFO_0801686
Diseaseglycoprotein measurement

CFH LPA ZFHX3 PLG

2.85e-04119784EFO_0004555
Diseasecholestasis (biomarker_via_orthology)

HPR MMP2 NR1H4

3.00e-0449783DOID:13580 (biomarker_via_orthology)
DiseaseAtypical Hemolytic Uremic Syndrome

CFH CFB

3.06e-0410782C2931788
Diseasenon-receptor tyrosine-protein kinase TYK2 measurement

CFH TSBP1

3.06e-0410782EFO_0008251
Diseasehydroxyproline measurement

CSMD1 SORCS1

3.06e-0410782EFO_0010498
Diseasearrhythmogenic right ventricular cardiomyopathy (is_implicated_in)

DSC2 RYR2

3.06e-0410782DOID:0050431 (is_implicated_in)
Diseaseinterleukin-37 measurement

CFH CFB

3.06e-0410782EFO_0020506
Diseasediabetic retinopathy (is_implicated_in)

CFH MMP2 CFB

3.18e-0450783DOID:8947 (is_implicated_in)
DiseaseSemantic-Pragmatic Disorder

CNTNAP2 GRIN2A

3.74e-0411782C0454655
DiseaseAuditory Processing Disorder, Central

CNTNAP2 GRIN2A

3.74e-0411782C0751257
DiseaseLanguage Delay

CNTNAP2 GRIN2A

3.74e-0411782C0023012
DiseaseLanguage Development Disorders

CNTNAP2 GRIN2A

3.74e-0411782C0023014
Diseasevascular dementia (is_marker_for)

LPA GRIN2A

3.74e-0411782DOID:8725 (is_marker_for)
DiseaseMarfan Syndrome

LTBP2 MMP2

3.74e-0411782C0024796
DiseaseSpeech Delay

CNTNAP2 GRIN2A

3.74e-0411782C0241210
Diseasebitter alcoholic beverage consumption measurement

CNTNAP2 PEPD ZFHX3 CSMD1

4.35e-04133784EFO_0010092
Diseasetriglycerides in LDL measurement

HPR LPA PLG

4.45e-0456783EFO_0022320
DiseaseMalignant neoplasm of breast

BMP1 FCRL3 DSC3 ROR1 ABCG2 KEAP1 MMP2 OCLN DDX3X SORCS1

5.22e-0410747810C0006142
Diseasecholangiocarcinoma (biomarker_via_orthology)

MMP2 NR1H4

5.28e-0413782DOID:4947 (biomarker_via_orthology)
Diseasetriglycerides in medium LDL measurement

HPR LPA PLG

6.01e-0462783EFO_0022322
Diseasewet macular degeneration

CFH CFB

6.15e-0414782EFO_0004683
DiseaseC-C motif chemokine 19 measurement

CFH HLA-DRB5

6.15e-0414782EFO_0008047
Diseasesusceptibility to hepatitis B infection measurement

GRIN2A CSMD1 WDR17

6.59e-0464783EFO_0008405
Diseasediabetic nephropathy

CNTNAP2 UMOD SORCS3 PLG

6.83e-04150784EFO_0000401
Diseaseresponse to statin, LDL cholesterol change measurement

LPA ABCG2

7.08e-0415782EFO_0007804, GO_0036273
DiseaseDrug-Induced Liver Disease

CFH BLVRB DSC2 MMP2 PLG NR1H4

7.11e-04404786C0860207
DiseaseChemical and Drug Induced Liver Injury

CFH BLVRB DSC2 MMP2 PLG NR1H4

7.11e-04404786C4277682
DiseaseDrug-Induced Acute Liver Injury

CFH BLVRB DSC2 MMP2 PLG NR1H4

7.11e-04404786C3658290
DiseaseHepatitis, Toxic

CFH BLVRB DSC2 MMP2 PLG NR1H4

7.11e-04404786C0019193
DiseaseChemically-Induced Liver Toxicity

CFH BLVRB DSC2 MMP2 PLG NR1H4

7.11e-04404786C4279912
DiseaseHepatitis, Drug-Induced

CFH BLVRB DSC2 MMP2 PLG NR1H4

7.11e-04404786C1262760
Diseaseautism spectrum disorder (implicated_via_orthology)

CNTNAP3B CNTNAP2 CNTNAP3 CTNND2

7.18e-04152784DOID:0060041 (implicated_via_orthology)
Diseaselow density lipoprotein cholesterol measurement, physical activity

HPR LPA CNTNAP2

7.21e-0466783EFO_0003940, EFO_0004611
Diseaseanti-anoctamin 2 antibody measurement

HLA-DRB5 CFB

9.14e-0417782EFO_0010150
Diseasemajor depressive disorder (is_implicated_in)

CNTNAP2 CTNND2

9.14e-0417782DOID:1470 (is_implicated_in)
DiseaseAge-related macular degeneration

CFH CFB

1.03e-0318782cv:C0242383
Diseaseinterleukin 18 measurement

OCLN LILRB1 TMED3

1.09e-0376783EFO_0004581
Diseasesquamous cell carcinoma (is_marker_for)

CFH MMP2

1.15e-0319782DOID:1749 (is_marker_for)
Diseaseschizophrenia (is_implicated_in)

CNTNAP2 GRIN2A CTNND2

1.17e-0378783DOID:5419 (is_implicated_in)
Diseasesevere acute respiratory syndrome, COVID-19

PTPN4 ZFHX3 LTBP2 CSMD1 EFCAB7 TMED3

1.20e-03447786EFO_0000694, MONDO_0100096
Diseaseunipolar depression

CFH ARSB SORCS3 ZFHX3 LTBP2 EML1 CTNND2 CSMD1 PCMTD1 CFB

1.26e-0312067810EFO_0003761
Diseaseatherosclerosis (biomarker_via_orthology)

HPR MMP2

1.27e-0320782DOID:1936 (biomarker_via_orthology)
Diseaseglaucoma (is_marker_for)

CFH MUC5AC

1.27e-0320782DOID:1686 (is_marker_for)
DiseaseEpilepsy, Cryptogenic

CNTNAP2 GRIN2A DDX3X

1.35e-0382783C0086237
DiseaseAwakening Epilepsy

CNTNAP2 GRIN2A DDX3X

1.35e-0382783C0751111
DiseaseAura

CNTNAP2 GRIN2A DDX3X

1.35e-0382783C0236018
DiseaseCOVID-19 (is_implicated_in)

CFH PLG

1.40e-0321782DOID:0080600 (is_implicated_in)
Diseasegastric ulcer (biomarker_via_orthology)

MMP2 MUC5AC

1.40e-0321782DOID:10808 (biomarker_via_orthology)
DiseaseDeep Vein Thrombosis

LPA PLG

1.40e-0321782C0149871
Diseasehaptoglobin measurement

HPR ZFHX3

1.40e-0321782EFO_0004640
DiseaseVenous Thrombosis

LPA PLG

1.40e-0321782C0042487
Diseasefacial morphology measurement

NHSL1 FSTL5 SORCS3 ZFHX3 CTNND2 CSMD1

1.48e-03466786EFO_0007841
DiseaseSplenomegaly

PEPD OCLN

1.54e-0322782C0038002

Protein segments in the cluster

PeptideGeneStartEntry
SYIEFHCGVDGYVDN

EDDM3A

121

Q14507
VSAHGNFYEGDCYVI

AVIL

31

O75366
TGYTGETCHSSLYEQ

CNTNAP3

576

Q9BZ76
TYGAVVHYSCRGSES

CSMD1

2876

Q96PZ7
TYYCHGGYEVEGTST

CSMD2

1581

Q7Z408
DTGHQLLDYCSGYVD

ABL2

1111

P42684
SNGYYHCESSIVIGE

AKAP7

271

Q9P0M2
QEALGYFESAGYHCE

ABCG2

271

Q9UNQ0
LRCLTTDEYDGHSTY

BLVRB

186

P30043
YEYSERGDAVCTESG

CFH

241

P08603
TLDYECHDGYESNTG

CFH

531

P08603
GYQCSGNDEHTSYGE

DTL

31

Q9NZJ0
DYTSTSEEEYGSRHG

CEP170B

1256

Q9Y4F5
DQSIECVDRAGYHYT

CCM2L

331

Q9NUG4
RSESCHTDGTYAYDA

CCM2L

356

Q9NUG4
DSCAYDYLEVRDGHS

BMP1

486

P13497
RKTDYECTGSNATYH

CTNND2

1086

Q9UQB3
GGHTEVDNCRYTYSE

DSC2

811

Q02487
SYDSCTTEGRTDGYR

MMP2

301

P08253
VECVDQHSQGTGAYY

RAVER2

666

Q9HCJ3
QSYHYEVCLTGDSGA

PCDHB5

746

Q9Y5E4
ELESLFEHYCYSRGG

PEPD

221

P12955
DHYETDYTTGGESCD

OCLN

396

Q16625
YGCYQVTCHSEEGNT

PTPN4

776

P29074
GDRASGYHYNALTCE

NR1H4

141

Q96RI1
EISFHCYDGYTLRGS

CFB

126

P00751
LYHEGYACTSIHGDR

DDX3X

461

O00571
QREIQEGAYSGSCYH

PASK

886

Q96RG2
HEHTDIQEYIGCYTS

MDN1

1111

Q9NU22
DRTGSHHCECYEGYT

MATN3

366

O15232
TYCRHNYGVGESFTV

HLA-DRB5

106

Q30154
ADQYDCITHYEGSTC

HPR

246

P00739
SVAEGYYSHRETVNG

CASP6

211

P55212
GSLYSEDHDGYCASV

NHSL1

601

Q5SYE7
DSHQYDRIYCGAGVQ

PCMTD1

156

Q96MG8
TSCGADNYGREHFLY

PCSK5

951

Q92824
TATDRDHGENGYVTY

FAT2

481

Q9NYQ8
GTEARCYTNHALSYD

EXOG

71

Q9Y2C4
ATCAVYGDGHYLTFD

MUC5AC

901

P98088
SQSYHYEVCVTGGSR

PCDHB12

746

Q9Y5F1
VTTTHVGNYTCYADG

FSTL5

311

Q8N475
LYEDRGFQGRHYECS

CRYGD

6

P07320
TGVYHCISSNYDDAD

IGSF10

546

Q6WRI0
RAEVSDSGSYYCHVE

IGSF3

771

O75054
GGHTEVDNCRYTYSE

DSC3

806

Q14574
DGYENIIVHTYSCDT

EFCAB7

546

A8K855
TLDGRVYDLHGSCSY

FCGBP

4866

Q9Y6R7
CVYKQYDRDHSGSLG

CAPNS2

156

Q96L46
VQDCYHGDGQSYRGS

LPA

1271

P08519
DCYHGDGRSYRGISS

LPA

1501

P08519
TNTEGSYHCECDQGY

LTBP2

946

Q14767
SDAGRYYCAADNVHS

FCRL3

351

Q96P31
GSEDYYSHERCTLID

ARSB

171

P15848
GYDGHTFLDSVECYD

KEAP1

571

Q14145
DETGYSGATCHNSIY

CNTNAP2

581

Q9UHC6
LERYHGYSCDCSNTA

CNTNAP2

981

Q9UHC6
HDNCIYIYGVSDNGR

EML1

646

O00423
DQLGGSCRTHYGYSS

DPEP1

371

P16444
YGDSVCYIQHVDTGL

RYR2

356

Q92736
GLVYNASGSEHCYDI

DPP7

311

Q9UHL4
TGYTGETCHSSLYEQ

CNTNAP3B

576

Q96NU0
CGTSDSDEGRYIEYI

SLC2A13

616

Q96QE2
SCGYYHSAFVTTDGE

RPGR

196

Q92834
TREEECHFYAGGQVY

PRDX4

46

Q13162
EHAGRYRCYYGSDTA

LILRB1

91

Q8NHL6
EECAITYSNSHGSYD

NBPF10

476

Q6P3W6
DFECDYGYERHGESQ

SORCS3

751

Q9UPU3
DHVCNASDNTGRYAY

SELENOO

361

Q9BVL4
DTVYDHGADVYGLTC

WDR17

646

Q8IZU2
DCYHGDGQSYRGTSS

PLG

376

P00747
HKCYNSTGVDYRGTV

ROR1

311

Q01973
DGSFTQVQCHTYTGY

SMOC1

121

Q9H4F8
STEYGEGYACDTDLR

UMOD

186

P07911
DYSCSSGYHLEGDRS

SRPX2

146

O60687
CAVQDYTYRGSISGH

SMRP1

66

Q8NCR6
QVITGGHYDVDCYVE

TMED3

56

Q9Y3Q3
EGLHYTEVCGYDIAS

TPP2

606

P29144
SCIYGEGYSNAHESK

SYNGR2

41

O43760
YEECGKITHSGEESY

ZNF355P

321

Q9NSJ1
ETHGCTYDYKSAGRR

ZFAND4

696

Q86XD8
ADFDCDYGYERHSNG

SORCS1

726

Q8WY21
YEDGRGSRHAYSTQS

TSBP1

51

Q5SRN2
SDDYLVVGCSDGSVY

WDR7

571

Q9Y4E6
EAYEEAALRCYGHEG

ZFTA

641

C9JLR9
QHESGVEGESCYYHC

ZFHX3

1076

Q15911
YCSRDSRGHNDVYIS

GRIN2A

1411

Q12879