Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionlow voltage-gated calcium channel activity

CACNA1I CACNA1G

4.89e-063262GO:0008332
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

CACNA1I CACNA1G SCN2A

4.99e-0626263GO:0005248
GeneOntologyMolecularFunctionsodium channel activity

CACNA1I CACNA1G SCN2A

4.15e-0552263GO:0005272
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1I CACNA1G

1.47e-0414262GO:0008331
GeneOntologyMolecularFunctionlysophospholipase activity

CLC ABHD16A

6.48e-0429262GO:0004622
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

CACNA1I CACNA1G SCN2A

1.39e-03171263GO:0015081
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1I CACNA1G

1.63e-0346262GO:0005245
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CACNA1I CACNA1G SCN2A

1.66e-03182263GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CACNA1I CACNA1G SCN2A

1.71e-03184263GO:0022832
GeneOntologyMolecularFunctiontransmembrane transporter activity

TCIRG1 CACNA1I ABCC12 SLC7A4 CACNA1G SCN2A

3.48e-031180266GO:0022857
GeneOntologyMolecularFunctiontransporter activity

TCIRG1 CACNA1I ABCC12 SLC7A4 CACNA1G SCN2A

5.38e-031289266GO:0005215
GeneOntologyMolecularFunctionexonuclease activity

REXO5 POLE

6.35e-0392262GO:0004527
GeneOntologyMolecularFunctionATP-dependent activity

TCIRG1 ABCC12 HSPH1 DNAH11

7.73e-03614264GO:0140657
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

TCIRG1 CACNA1I CACNA1G SCN2A

8.31e-03627264GO:0022890
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

TCIRG1 ABCC12

8.81e-03109262GO:0042626
GeneOntologyMolecularFunctiongated channel activity

CACNA1I CACNA1G SCN2A

9.07e-03334263GO:0022836
GeneOntologyMolecularFunctionphospholipase activity

CLC ABHD16A

9.60e-03114262GO:0004620
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1I CACNA1G SCN2A

9.75e-03343263GO:0005261
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

TCIRG1 CACNA1I CACNA1G SCN2A

1.01e-02664264GO:0008324
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1I CACNA1G

1.22e-02129262GO:0005262
GeneOntologyBiologicalProcessmembrane depolarization during action potential

CACNA1I CACNA1G SCN2A

1.09e-0536253GO:0086010
GeneOntologyBiologicalProcessneuronal action potential

CACNA1I CACNA1G SCN2A

5.95e-0563253GO:0019228
GeneOntologyCellularComponentvoltage-gated sodium channel complex

CACNA1I CACNA1G SCN2A

1.15e-0617263GO:0001518
GeneOntologyCellularComponentsodium channel complex

CACNA1I CACNA1G SCN2A

6.11e-0629263GO:0034706
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1I CACNA1G

1.49e-0346262GO:0005891
GeneOntologyCellularComponentcation channel complex

CACNA1I CACNA1G SCN2A

3.01e-03235263GO:0034703
GeneOntologyCellularComponentcalcium channel complex

CACNA1I CACNA1G

3.70e-0373262GO:0034704
GeneOntologyCellularComponenttransmembrane transporter complex

TCIRG1 CACNA1I CACNA1G SCN2A

3.74e-03523264GO:1902495
GeneOntologyCellularComponenttransporter complex

TCIRG1 CACNA1I CACNA1G SCN2A

4.47e-03550264GO:1990351
DomainVDCC_T_a1

CACNA1I CACNA1G

5.16e-063252IPR005445
DomainChannel_four-helix_dom

CACNA1I CACNA1G SCN2A

5.91e-0557253IPR027359
Domain-

CACNA1I CACNA1G SCN2A

5.91e-05572531.20.120.350
DomainVDCCAlpha1

CACNA1I CACNA1G

7.69e-0510252IPR002077
DomainGal-bind_lectin

CLC LGALS4

1.79e-0415252SM00908
DomainGALECTIN

CLC LGALS4

1.79e-0415252PS51304
DomainGalectin_CRD

CLC LGALS4

1.79e-0415252IPR001079
DomainGal-bind_lectin

CLC LGALS4

1.79e-0415252PF00337
DomainGLECT

CLC LGALS4

1.79e-0415252SM00276
DomainIon_trans_dom

CACNA1I CACNA1G SCN2A

4.62e-04114253IPR005821
DomainIon_trans

CACNA1I CACNA1G SCN2A

4.62e-04114253PF00520
Domain-

REXO5 POLE

1.79e-03472523.30.420.10
DomainRNaseH-like_dom

REXO5 POLE

3.82e-0369252IPR012337
Domain-

CLC LGALS4

7.12e-03952522.60.120.200
DomainAAA+_ATPase

ABCC12 DNAH11

1.58e-02144252IPR003593
DomainAAA

ABCC12 DNAH11

1.58e-02144252SM00382
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1I CACNA1G

3.01e-0423162M47666
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1I CACNA1G

3.57e-0425162M47948
Pubmed

Contribution of postsynaptic T-type calcium channels to parallel fibre-Purkinje cell synaptic responses.

CACNA1I CACNA1G

5.37e-07226226627919
Pubmed

Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.

CACNA1I CACNA1G

1.61e-06326228846697
Pubmed

Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures.

CACNA1I CACNA1G

1.61e-06326233547341
Pubmed

Calmodulin regulates Cav3 T-type channels at their gating brake.

CACNA1I CACNA1G

1.61e-06326228972185
Pubmed

Global genetic deletion of CaV3.3 channels facilitates anaesthetic induction and enhances isoflurane-sparing effects of T-type calcium channel blockers.

CACNA1I CACNA1G

1.61e-06326233299036
Pubmed

Ethanol inhibition of a T-type Ca²+ channel through activity of protein kinase C.

CACNA1I CACNA1G

1.61e-06326223488970
Pubmed

Growth differentiation factor-15 promotes glutamate release in medial prefrontal cortex of mice through upregulation of T-type calcium channels.

CACNA1I CACNA1G

1.61e-06326227353765
Pubmed

Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability.

CACNA1I CACNA1G

1.61e-06326211927664
Pubmed

T-type channels: release a brake, engage a gear.

CACNA1I CACNA1G

1.61e-06326226488564
Pubmed

Differential interactions of Na+ channel toxins with T-type Ca2+ channels.

CACNA1I CACNA1G

1.61e-06326218591418
Pubmed

Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse heart.

CACNA1I CACNA1G

1.61e-06326211230107
Pubmed

Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.

CACNA1I CACNA1G

1.61e-06326211897840
Pubmed

Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.

CACNA1I CACNA1G

3.22e-06426228165634
Pubmed

Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1.

FCGBP ABHD16A LGALS4

1.00e-055626320706999
Pubmed

Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.

CACNA1I CACNA1G

1.50e-05826228330839
Pubmed

Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord.

CACNA1I CACNA1G

1.50e-05826234478646
Pubmed

Intracellular calcium plays an essential role in cardiac development.

CACNA1I CACNA1G

1.50e-05826212761855
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1I CACNA1G

1.93e-05926216382099
Pubmed

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

CALCR CCNL1

1.93e-05926223202124
Pubmed

Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage.

CACNA1I CACNA1G

2.41e-051026224778262
Pubmed

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.

TCIRG1 ERMP1 OGDH HSPH1

2.59e-0442226427342126
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1I CACNA1G

3.72e-043826230786075
Pubmed

Mapping of transcription start sites of human retina expressed genes.

ELOVL4 MPP4

5.22e-044526217286855
Pubmed

Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation.

ELOVL4 CACNA1G

5.45e-044626234815492
Cytoband19q13.1

FCGBP CLC

4.50e-045526219q13.1
CytobandEnsembl 112 genes in cytogenetic band chr13q12

RNF17 HSPH1

7.76e-03234262chr13q12
GeneFamilyGalectins

CLC LGALS4

1.09e-0415192629
GeneFamilyCalcium voltage-gated channel subunits

CACNA1I CACNA1G

3.35e-0426192253
GeneFamilyRing finger proteins

RNF17 RNF133

3.32e-0227519258
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage_4|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CACNA1G ABHD16A LGALS4

6.53e-05135263c4d3c9eba2a85ac40fea5ecfcc2b442a472323d0
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ERMP1 FCGBP DNAH11

1.29e-041702635d5f208682be21ed58320f5fc083a7898f8712da
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FCGBP CALCR SCN2A

1.36e-041732630c74bdb40e635d906fd180412c23bf7fed61621e
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1I FCGBP LGALS4

1.38e-04174263e7cca4b6a3935fad61cf2a3d9984ab1ffa1a9447
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1I FCGBP LGALS4

1.38e-04174263ad5b56f0ace6455c033834b931ec870cc0dc9290
ToppCell3'-GW_trimst-1-LargeIntestine-Epithelial-progenitor-Germ|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1I ABCC12 RNF17

1.43e-04176263eea554ea75580f8dd5fefb57e7f33441ab86b884
ToppCell3'-GW_trimst-1-LargeIntestine-Epithelial-progenitor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1I ABCC12 RNF17

1.43e-04176263d5cee483d2a60f82fdc67ad447b589d022fe8c97
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Granulocytic-Mast_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC7A4 REXO5 DNAH11

1.46e-0417726386c41d262142eeaa95ea7fa6668169eb1bb2953f
ToppCellControl-Epithelial_cells-Airway_mucous|Control / group, cell type (main and fine annotations)

FCGBP SCN2A LGALS4

1.61e-0418326315d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCellwk_20-22-Hematologic-Myeloid-Basophil|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CLC REXO5 CXorf65

1.61e-0418326393d821d5340caed0eef455d3d738be213ce5fff8
ToppCellFrontal_cortex-Neuronal-Excitatory|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SLC7A4 SCN2A HSPH1

1.63e-041842636e17c8151d6dc543de16d804db956c63c3fda414
ToppCellfacs-Heart-LV-24m-Myeloid-macrophage|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC7A4 FCGBP LGALS4

1.66e-04185263a835f821a5e6568d648df831ec4c2d0048d67093
ToppCellfacs-Heart-LV-24m-Myeloid-macrophage|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC7A4 FCGBP LGALS4

1.66e-04185263386b08bcb304db543e3c5ff75f85e99bf0c592df
ToppCellfacs-Limb_Muscle|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CALCR HSPH1 CCNL1

1.77e-0418926321ec43859d21ffc565acbe36489da1d2d0f9877d
ToppCellNS-moderate-d_0-4-Myeloid-Resident_Macrophage|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FCGBP POLE LGALS4

1.88e-04193263e530d4349b257f2590c799bf082ed6318700c526
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-keratinocyte|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL4 IL15 ERMP1

1.94e-04195263c54b19e31efe2c9ae690062569da7c0f1120a1d8
ToppCell343B-Lymphocytic-NK_cells-NK_cell_A|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

TCIRG1 HSPH1 CCNL1

2.00e-04197263cd54e6ad175529327fa0372033016b3b978dd452
ToppCellParenchyma_COVID-19-Immune-TX-MoAM-4|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

TCIRG1 CACNA1G CALCR

2.03e-04198263a7eed9eeb728a8796e2780090cc244856efd8c65
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CACNA1I SLC7A4 SCN2A

2.09e-042002632f481e2fd248c02a5aa2e0248c16808df142fed2
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CACNA1I SLC7A4 SCN2A

2.09e-04200263dc674124475edf83908b51a4e1454bc2dc4f06fa
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CACNA1I SLC7A4 SCN2A

2.09e-04200263bd4b9f6b37f4a3c960c4149cf0cfd2caf3327d2d
DrugZonisamide

CACNA1I CACNA1G SCN2A

8.89e-0717263DB00909
Drug1,3-dioxoisoindoline-5-carboxamide

CACNA1I CACNA1G

3.76e-063262CID010679219
DrugFlunarizine

CACNA1I CACNA1G

1.25e-055262DB04841
Drug3,4-dihydroquinazoline

CACNA1I CACNA1G

1.88e-056262CID000583065
DrugLY215840

CACNA1I CACNA1G

2.62e-057262CID000132049
DrugAC1L1FXZ

CALCR OGDH

3.50e-058262CID000003441
DrugCinildipine

CACNA1I CACNA1G CALCR

3.52e-0556263CID000002752
DrugCinnarizine

CACNA1I CACNA1G

4.49e-059262DB00568
DrugEbna

IL15 CALCR POLE LGALS4

5.26e-05183264CID000018835
Drugadefovir

ABCC12 CALCR POLE

5.26e-0564263CID000060172
DrugMibefradil

CACNA1I CACNA1G

6.85e-0511262DB01388
DrugEBNs

CACNA1I CACNA1G

6.85e-0511262CID000150695
Drugsodium 4-phenylbutyrate; Up 200; 1000uM; PC3; HG-U133A

TCIRG1 CACNA1I CLC RNF17

7.14e-05198264434_UP
Drugthemisone

CACNA1I CACNA1G

8.22e-0512262CID000016235
DrugAC1L2VU3

CACNA1I CACNA1G

8.22e-0512262CID000129572
Drugtetralol

CACNA1I CACNA1G

9.71e-0513262CID000010747
DrugMibefradil

CACNA1I CACNA1G

9.71e-0513262ctd:D020748
Drugphorbol acetate myristate

CACNA1I IL15 CACNA1G CLC CALCR POLE HSPH1 LGALS4

1.15e-041399268CID000004792
DrugAC1L1CS9

TCIRG1 IL15

1.30e-0415262CID000002037
Drugpentasulfane

CACNA1I CACNA1G

1.49e-0416262CID000448216
DrugAC1L3XKM

TCIRG1 SCN2A

1.49e-0416262CID000123930
DrugVerapamil

CACNA1I CACNA1G

1.49e-0416262DB00661
Drugcyclopropanecarboxylic acid

CACNA1I CACNA1G

2.12e-0419262CID000015655
Drugpyraclofos

CACNA1I CACNA1G SCN2A

2.36e-04106263CID000093460
Diseasepyridoxate measurement

IL15 ABHD16A

2.67e-0431232EFO_0010527
Diseaselow density lipoprotein cholesterol measurement, physical activity

OGDH DNAH11

1.21e-0366232EFO_0003940, EFO_0004611
Diseasebehavioural disinhibition measurement

CACNA1I DNAH11

1.56e-0375232EFO_0006946
DiseaseHodgkins lymphoma

CACNA1I FCGBP

1.86e-0382232EFO_0000183
Diseasesmoking cessation

OGDH SCN2A CCNL1

1.99e-03325233EFO_0004319
Diseaset-tau measurement

IL15 MPP4

4.32e-03126232EFO_0004760

Protein segments in the cluster

PeptideGeneStartEntry
MFIFIKHGDNQQFLV

CXorf65

1

A6NEN9
IHGPVMAALVVNFFF

CALCR

301

P30988
MDVVVQFAIHRLGFQ

ABHD16A

331

O95870
IDDIVVEGFFQAIMH

DNAH11

911

Q96DT5
AMAADGLFFQVFAHV

SLC7A4

346

O43246
QVAMATGQVLFHRFF

CCNL1

101

Q9UK58
HGNMVFFDVLGLFVI

ERMP1

396

Q7Z2K6
EHMKRFFVNFVVGQD

LGALS4

41

P56470
AFFGAQLNSFIHVIM

ELOVL4

181

Q9GZR5
EFLQSFVHIVQMFIN

IL15

146

P40933
RIVVFVDMGHSAFQV

HSPH1

196

Q92598
RMETQFGQFFDHVIV

MPP4

586

Q96JB8
VFHFQVCFGRRVVMN

CLC

51

Q05315
IHTQVFMEQIGIFRN

POLE

2246

Q07864
MTQVFGEHFFRGVEV

OR4C13

96

Q8NGP0
HLQFERFVVAAGENM

METTL7A

116

Q9H8H3
QHIGVEFMFINDLEQ

OGDH

216

Q02218
MFVGVVVENFHKCRQ

CACNA1G

1531

O43497
VGQVHIFFQDGMVTL

FCGBP

5291

Q9Y6R7
FVLNMFVGVVVENFH

CACNA1I

1421

Q9P0X4
GNQVFPMFHQAFEDV

RNF133

136

Q8WVZ7
HAENFLQQFFMVVFI

ABCC12

926

Q96J65
FVHEVALIQIFMVDF

RNF17

506

Q9BXT8
NVVVFVLQGMSQLHF

REXO5

96

Q96IC2
VFTTMEALQEHVQFG

FAM170A

236

A1A519
QGMVFDFVTKQVFDI

SCN2A

1521

Q99250
MAFGVVLGVFNHVHF

TCIRG1

546

Q13488