Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	coumarin 7-hydroxylase activity	CYP2A6 CYP2A7 CYP2A13	4.11e-09	3	33	3	GO:0008389
GeneOntologyMolecularFunction	potassium:sodium symporter activity	SLC12A1 SLC12A2	7.94e-06	3	33	2	GO:0009674
GeneOntologyMolecularFunction	sodium:potassium:chloride symporter activity	SLC12A1 SLC12A2	7.94e-06	3	33	2	GO:0008511
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP2A6 CYP2A7 CYP2A13	8.13e-06	24	33	3	GO:0008392
GeneOntologyMolecularFunction	solute:sodium symporter activity	SLC6A5 SLC12A1 SLC12A2 SLC4A4	9.40e-06	81	33	4	GO:0015370
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP2A6 CYP2A7 CYP2A13	1.17e-05	27	33	3	GO:0008391
GeneOntologyMolecularFunction	steroid hydroxylase activity	CYP2A6 CYP2A7 CYP2A13	2.38e-05	34	33	3	GO:0008395
GeneOntologyMolecularFunction	aromatase activity	CYP2A6 CYP2A7 CYP2A13	2.60e-05	35	33	3	GO:0070330
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC6A5 SLC12A1 SLC12A2 SLC4A4	4.29e-05	119	33	4	GO:0015294
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2A6 CYP2A7 CYP2A13	7.19e-05	49	33	3	GO:0016712
GeneOntologyMolecularFunction	neuropeptide receptor activity	GPR83 TACR1 GALR2	9.11e-05	53	33	3	GO:0008188
GeneOntologyMolecularFunction	potassium:chloride symporter activity	SLC12A1 SLC12A2	9.47e-05	9	33	2	GO:0015379
GeneOntologyMolecularFunction	symporter activity	SLC6A5 SLC12A1 SLC12A2 SLC4A4	1.06e-04	150	33	4	GO:0015293
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	OCA2 SLC12A1 SLC12A2 SLC4A4	1.08e-04	151	33	4	GO:0008509
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC6A5 SLC12A1 SLC12A2 SLC4A4 ATP6V0A4	1.26e-04	301	33	5	GO:0022853
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	OCA2 SLC12A1 SLC12A2 SLC4A4	1.75e-04	171	33	4	GO:0015103
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC6A5 SLC12A1 SLC12A2 SLC4A4	1.75e-04	171	33	4	GO:0015081
GeneOntologyMolecularFunction	transporter activity	NPC1 SLC6A5 OCA2 SLC12A1 SLC12A2 SLC4A4 KCNG3 ATP10D ATP6V0A4	1.77e-04	1289	33	9	GO:0005215
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC6A5 OCA2 SLC12A1 SLC12A2 SLC4A4 KCNG3 ATP6V0A4	1.99e-04	758	33	7	GO:0015318
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC6A5 OCA2 SLC12A1 SLC12A2 SLC4A4 KCNG3 ATP6V0A4	2.62e-04	793	33	7	GO:0015075
GeneOntologyMolecularFunction	sodium:chloride symporter activity	SLC12A1 SLC12A2	3.55e-04	17	33	2	GO:0015378
GeneOntologyMolecularFunction	monoatomic anion:sodium symporter activity	SLC12A1 SLC12A2	4.45e-04	19	33	2	GO:0015373
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC6A5 SLC12A1 SLC12A2 SLC4A4 KCNG3 ATP6V0A4	5.03e-04	627	33	6	GO:0022890
GeneOntologyMolecularFunction	chloride:monoatomic cation symporter activity	SLC12A1 SLC12A2	6.56e-04	23	33	2	GO:0015377
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC6A5 SLC12A1 SLC12A2 SLC4A4 KCNG3 ATP6V0A4	6.80e-04	664	33	6	GO:0008324
GeneOntologyMolecularFunction	monoatomic anion:monoatomic cation symporter activity	SLC12A1 SLC12A2	8.40e-04	26	33	2	GO:0015296
GeneOntologyMolecularFunction	monooxygenase activity	CYP2A6 CYP2A7 CYP2A13	8.95e-04	115	33	3	GO:0004497
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC6A5 SLC12A1 SLC12A2 SLC4A4 KCNG3	9.28e-04	465	33	5	GO:0046873
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC6A5 SLC12A1 SLC12A2 SLC4A4 ATP6V0A4	1.04e-03	477	33	5	GO:0022804
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	OCA2 SLC12A1 SLC12A2	1.14e-03	125	33	3	GO:0015108
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	GPR83 TACR1 GALR2	1.36e-03	133	33	3	GO:0008528
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC6A5 SLC12A1 SLC12A2 SLC4A4	1.38e-03	296	33	4	GO:0015291
GeneOntologyMolecularFunction	peptide receptor activity	GPR83 TACR1 GALR2	1.58e-03	140	33	3	GO:0001653
GeneOntologyMolecularFunction	heme binding	CYP2A6 CYP2A7 CYP2A13	2.07e-03	154	33	3	GO:0020037
GeneOntologyMolecularFunction	tetrapyrrole binding	CYP2A6 CYP2A7 CYP2A13	2.48e-03	164	33	3	GO:0046906
GeneOntologyMolecularFunction	iron ion binding	CYP2A6 CYP2A7 CYP2A13	2.56e-03	166	33	3	GO:0005506
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	SLC12A1 SLC12A2 KCNG3	2.61e-03	167	33	3	GO:0015079
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC6A5 OCA2 SLC12A1 SLC12A2 SLC4A4 KCNG3 ATP6V0A4	2.72e-03	1180	33	7	GO:0022857
GeneOntologyMolecularFunction	G protein-coupled receptor activity	GPR83 TACR1 CMKLR1 GALR2 RHO OR4E2	2.94e-03	884	33	6	GO:0004930
GeneOntologyMolecularFunction	peptide hormone binding	CMKLR1 GALR2	3.72e-03	55	33	2	GO:0017046
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	CYP2A6 CYP2A7 CYP2A13	3.98e-03	194	33	3	GO:0016705
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	NPC1 GPR83 TACR1 CMKLR1 GALR2 RHO OR4E2	5.80e-03	1353	33	7	GO:0004888
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	ACER2 PIGL	7.91e-03	81	33	2	GO:0016811
GeneOntologyMolecularFunction	hormone binding	CMKLR1 GALR2	1.25e-02	103	33	2	GO:0042562
GeneOntologyBiologicalProcess	phenylpropanoid metabolic process	CYP2A6 CYP2A7 CYP2A13	4.44e-07	10	33	3	GO:0009698
GeneOntologyBiologicalProcess	coumarin metabolic process	CYP2A6 CYP2A7 CYP2A13	4.44e-07	10	33	3	GO:0009804
GeneOntologyBiologicalProcess	secondary metabolic process	CYP2A6 CYP2A7 CYP2A13 OCA2	3.88e-06	67	33	4	GO:0019748
GeneOntologyBiologicalProcess	arachidonate metabolic process	CYP2A6 CYP2A7 CYP2A13 DAGLA	4.11e-06	68	33	4	GO:0019369
GeneOntologyBiologicalProcess	epoxygenase P450 pathway	CYP2A6 CYP2A7 CYP2A13	5.63e-06	22	33	3	GO:0019373
GeneOntologyBiologicalProcess	excretion	LIPA TACR1 ATP6V0A4	2.79e-05	37	33	3	GO:0007588
GeneOntologyBiologicalProcess	long-chain fatty acid metabolic process	CYP2A6 CYP2A7 CYP2A13 DAGLA	4.45e-05	124	33	4	GO:0001676
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	SLC6A5 OCA2 SLC12A1 SLC12A2 SLC4A4 KCNG3 GALR2 ATP10D ATP6V0A4	4.53e-05	1115	33	9	GO:0034220
GeneOntologyBiologicalProcess	unsaturated fatty acid metabolic process	CYP2A6 CYP2A7 CYP2A13 DAGLA	5.04e-05	128	33	4	GO:0033559
GeneOntologyBiologicalProcess	phospholipase C-activating G protein-coupled receptor signaling pathway	GPR83 TACR1 CMKLR1 GALR2	5.85e-05	133	33	4	GO:0007200
GeneOntologyBiologicalProcess	icosanoid metabolic process	CYP2A6 CYP2A7 CYP2A13 DAGLA	7.54e-05	142	33	4	GO:0006690
GeneOntologyBiologicalProcess	monoatomic anion transmembrane transport	OCA2 SLC12A1 SLC12A2 SLC4A4	1.01e-04	153	33	4	GO:0098656
GeneOntologyBiologicalProcess	monocarboxylic acid metabolic process	NPC1 CYP2A6 CYP2A7 CYP2A13 LIPA SLC4A4 DAGLA	1.30e-04	731	33	7	GO:0032787
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	SLC6A5 OCA2 SLC12A1 SLC12A2 SLC4A4 KCNG3 GALR2 ATP6V0A4	1.57e-04	1017	33	8	GO:0098660
GeneOntologyBiologicalProcess	response to cadmium ion	NPC1 CYP2A6 CYP2A13	1.74e-04	68	33	3	GO:0046686
GeneOntologyBiologicalProcess	carboxylic acid metabolic process	NPC1 CYP2A6 CYP2A7 CYP2A13 OCA2 LIPA SLC4A4 DAGLA	1.77e-04	1035	33	8	GO:0019752
GeneOntologyBiologicalProcess	inorganic anion transport	OCA2 SLC12A1 SLC12A2 SLC4A4	1.88e-04	180	33	4	GO:0015698
GeneOntologyBiologicalProcess	olefinic compound metabolic process	CYP2A6 CYP2A7 CYP2A13 DAGLA	1.88e-04	180	33	4	GO:0120254
GeneOntologyBiologicalProcess	monoatomic anion transport	OCA2 SLC12A1 SLC12A2 SLC4A4	2.01e-04	183	33	4	GO:0006820
GeneOntologyBiologicalProcess	oxoacid metabolic process	NPC1 CYP2A6 CYP2A7 CYP2A13 OCA2 LIPA SLC4A4 DAGLA	2.05e-04	1058	33	8	GO:0043436
GeneOntologyBiologicalProcess	organic acid metabolic process	NPC1 CYP2A6 CYP2A7 CYP2A13 OCA2 LIPA SLC4A4 DAGLA	2.14e-04	1064	33	8	GO:0006082
GeneOntologyBiologicalProcess	monoatomic ion transport	SLC6A5 OCA2 SLC12A1 SLC12A2 SLC4A4 KCNG3 GALR2 ATP10D ATP6V0A4	2.25e-04	1374	33	9	GO:0006811
GeneOntologyBiologicalProcess	regulation of membrane potential	CKAP5 LIPA TACR1 SLC4A4 KCNG3 TMEM161B	2.29e-04	559	33	6	GO:0042391
GeneOntologyBiologicalProcess	sodium ion transmembrane transport	SLC6A5 SLC12A1 SLC12A2 SLC4A4	3.27e-04	208	33	4	GO:0035725
GeneOntologyBiologicalProcess	monoatomic cation transport	SLC6A5 SLC12A1 SLC12A2 SLC4A4 KCNG3 GALR2 ATP10D ATP6V0A4	3.77e-04	1157	33	8	GO:0006812
GeneOntologyBiologicalProcess	regulation of intracellular pH	OCA2 SLC4A4 ATP6V0A4	4.53e-04	94	33	3	GO:0051453
GeneOntologyBiologicalProcess	pigment metabolic process	CYP2A6 CYP2A13 OCA2	4.53e-04	94	33	3	GO:0042440
GeneOntologyBiologicalProcess	organic hydroxy compound metabolic process	ACER2 NPC1 OCA2 LIPA ERG28 GALR2	4.76e-04	641	33	6	GO:1901615
GeneOntologyBiologicalProcess	potassium ion transmembrane transport	SLC12A1 SLC12A2 KCNG3 GALR2	4.94e-04	232	33	4	GO:0071805
GeneOntologyBiologicalProcess	positive regulation of T cell receptor signaling pathway	UBR2 LIPA	5.11e-04	21	33	2	GO:0050862
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	SLC6A5 SLC12A1 SLC12A2 SLC4A4 KCNG3 GALR2 ATP6V0A4	5.37e-04	922	33	7	GO:0098662
GeneOntologyBiologicalProcess	regulation of cellular pH	OCA2 SLC4A4 ATP6V0A4	5.59e-04	101	33	3	GO:0030641
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	SLC6A5 SLC12A1 SLC12A2 SLC4A4 KCNG3 GALR2 ATP6V0A4	6.10e-04	942	33	7	GO:0098655
GeneOntologyBiologicalProcess	chloride ion homeostasis	SLC12A1 SLC12A2	7.28e-04	25	33	2	GO:0055064
GeneOntologyBiologicalProcess	chloride transmembrane transport	OCA2 SLC12A1 SLC12A2	7.55e-04	112	33	3	GO:1902476
GeneOntologyBiologicalProcess	fatty acid metabolic process	CYP2A6 CYP2A7 CYP2A13 LIPA DAGLA	7.73e-04	461	33	5	GO:0006631
GeneOntologyBiologicalProcess	cholesterol storage	NPC1 LIPA	7.88e-04	26	33	2	GO:0010878
GeneOntologyBiologicalProcess	potassium ion transport	SLC12A1 SLC12A2 KCNG3 GALR2	8.96e-04	272	33	4	GO:0006813
GeneOntologyBiologicalProcess	monoatomic anion homeostasis	SLC12A1 SLC12A2	9.14e-04	28	33	2	GO:0055081
GeneOntologyBiologicalProcess	regulation of pH	OCA2 SLC4A4 ATP6V0A4	9.22e-04	120	33	3	GO:0006885
GeneOntologyBiologicalProcess	sodium ion transport	SLC6A5 SLC12A1 SLC12A2 SLC4A4	9.33e-04	275	33	4	GO:0006814
GeneOntologyBiologicalProcess	organic hydroxy compound biosynthetic process	ACER2 OCA2 LIPA ERG28	9.58e-04	277	33	4	GO:1901617
GeneOntologyBiologicalProcess	chloride transport	OCA2 SLC12A1 SLC12A2	1.11e-03	128	33	3	GO:0006821
GeneOntologyBiologicalProcess	positive regulation of antigen receptor-mediated signaling pathway	UBR2 LIPA	1.12e-03	31	33	2	GO:0050857
GeneOntologyBiologicalProcess	inorganic anion transmembrane transport	OCA2 SLC12A1 SLC12A2	1.27e-03	134	33	3	GO:0098661
GeneOntologyBiologicalProcess	response to xenobiotic stimulus	NPC1 CYP2A6 CYP2A7 CYP2A13 LIPA	1.38e-03	525	33	5	GO:0009410
GeneOntologyBiologicalProcess	xenobiotic metabolic process	CYP2A6 CYP2A7 CYP2A13	1.47e-03	141	33	3	GO:0006805
GeneOntologyBiologicalProcess	potassium ion homeostasis	SLC12A1 SLC12A2	1.60e-03	37	33	2	GO:0055075
GeneOntologyBiologicalProcess	response to lipid	ACER2 NPC1 CFH GPR83 LIPA TACR1 SLC12A2	1.73e-03	1126	33	7	GO:0033993
GeneOntologyBiologicalProcess	cell volume homeostasis	SLC12A1 SLC12A2	2.05e-03	42	33	2	GO:0006884
GeneOntologyBiologicalProcess	cellular response to cadmium ion	CYP2A6 CYP2A13	2.15e-03	43	33	2	GO:0071276
GeneOntologyBiologicalProcess	feeding behavior	GPR83 TACR1 GALR2	2.18e-03	162	33	3	GO:0007631
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	ITPRIP CYP2A6 CYP2A7 PIGL CYP2A13 OCA2 CALR3 ERG28 REEP4 ATP10D RHO	3.41e-06	1327	33	11	GO:0042175
GeneOntologyCellularComponent	endoplasmic reticulum membrane	CYP2A6 CYP2A7 PIGL CYP2A13 OCA2 CALR3 ERG28 REEP4 ATP10D RHO	1.97e-05	1293	33	10	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	CYP2A6 CYP2A7 PIGL CYP2A13 OCA2 CALR3 ERG28 REEP4 ATP10D RHO	2.05e-05	1299	33	10	GO:0098827
GeneOntologyCellularComponent	cytoplasmic microtubule	CYP2A6 CYP2A7 CYP2A13 REEP4	5.55e-05	133	33	4	GO:0005881
GeneOntologyCellularComponent	sperm head	TACR1 RHO	1.02e-03	30	33	2	GO:0061827
GeneOntologyCellularComponent	microtubule	CKAP5 CYP2A6 CYP2A7 CYP2A13 REEP4	1.39e-03	533	33	5	GO:0005874
MousePheno	decreased intestinal cholesterol absorption	CYP2A6 CYP2A7 CYP2A13	4.80e-06	17	28	3	MP:0002647
MousePheno	abnormal intestinal cholesterol absorption	CYP2A6 CYP2A7 CYP2A13	6.83e-06	19	28	3	MP:0002645
MousePheno	coiled cecum	SLC12A2 SLC4A4	1.16e-05	3	28	2	MP:0009478
MousePheno	abnormal alveolar macrophage morphology	NPC1 LIPA CMKLR1	2.04e-05	27	28	3	MP:0008245
MousePheno	acidosis	SLC12A1 SLC4A4 ATP6V0A4	2.28e-05	28	28	3	MP:0003031
MousePheno	abnormal intestinal lipid absorption	CYP2A6 CYP2A7 CYP2A13	3.12e-05	31	28	3	MP:0005342
MousePheno	abnormal pH regulation	SLC12A1 SLC4A4 ATP6V0A4	7.84e-05	42	28	3	MP:0004043
MousePheno	abnormal bile salt homeostasis	CYP2A6 CYP2A7 CYP2A13	1.10e-04	47	28	3	MP:0005365
MousePheno	abnormal intestinal absorption	CYP2A6 CYP2A7 CYP2A13	2.17e-04	59	28	3	MP:0001666
MousePheno	metabolic acidosis	SLC12A1 SLC4A4	2.52e-04	12	28	2	MP:0012551
MousePheno	decreased urine pH	SLC4A4 ATP6V0A4	2.52e-04	12	28	2	MP:0009350
MousePheno	retina detachment	CFH RHO	4.00e-04	15	28	2	MP:0003099
MousePheno	abnormal eye pigmentation	CFH OCA2 TMEM161B RHO	4.19e-04	179	28	4	MP:0001324
MousePheno	abnormal extracutaneous pigmentation	CFH OCA2 TMEM161B RHO	4.84e-04	186	28	4	MP:0009389
Domain	Cyt_P450_E_grp-I_CYP2A-like	CYP2A6 CYP2A7 CYP2A13	2.01e-08	4	33	3	IPR008067
Domain	Na/K/Cl_cotranspt	SLC12A1 SLC12A2	3.03e-06	2	33	2	IPR002443
Domain	AA_permease_N	SLC12A1 SLC12A2	9.07e-06	3	33	2	IPR013612
Domain	AA_permease_N	SLC12A1 SLC12A2	9.07e-06	3	33	2	PF08403
Domain	SLC12A_fam	SLC12A1 SLC12A2	6.32e-05	7	33	2	IPR004842
Domain	Cyt_P450_E_grp-I	CYP2A6 CYP2A7 CYP2A13	6.78e-05	45	33	3	IPR002401
Domain	SLC12	SLC12A1 SLC12A2	8.42e-05	8	33	2	PF03522
Domain	SLC12_C	SLC12A1 SLC12A2	8.42e-05	8	33	2	IPR018491
Domain	Cyt_P450_CS	CYP2A6 CYP2A7 CYP2A13	1.11e-04	53	33	3	IPR017972
Domain	CYTOCHROME_P450	CYP2A6 CYP2A7 CYP2A13	1.38e-04	57	33	3	PS00086
Domain	-	CYP2A6 CYP2A7 CYP2A13	1.45e-04	58	33	3	1.10.630.10
Domain	p450	CYP2A6 CYP2A7 CYP2A13	1.45e-04	58	33	3	PF00067
Domain	Cyt_P450	CYP2A6 CYP2A7 CYP2A13	1.61e-04	60	33	3	IPR001128
Domain	AA-permease/SLC12A_dom	SLC12A1 SLC12A2	6.84e-04	22	33	2	IPR004841
Domain	AA_permease	SLC12A1 SLC12A2	6.84e-04	22	33	2	PF00324
Domain	LIPASE_SER	LIPA DAGLA	9.58e-04	26	33	2	PS00120
Domain	7TM_GPCR_Srsx	GPR83 GALR2 RHO	1.00e-03	112	33	3	SM01381
Domain	GPCR_Rhodpsn_7TM	GPR83 TACR1 CMKLR1 GALR2 RHO OR4E2	1.01e-03	670	33	6	IPR017452
Domain	7tm_1	GPR83 TACR1 CMKLR1 GALR2 RHO OR4E2	1.06e-03	677	33	6	PF00001
Domain	G_PROTEIN_RECEP_F1_1	GPR83 TACR1 CMKLR1 GALR2 RHO OR4E2	1.13e-03	685	33	6	PS00237
Domain	G_PROTEIN_RECEP_F1_2	GPR83 TACR1 CMKLR1 GALR2 RHO OR4E2	1.18e-03	691	33	6	PS50262
Domain	GPCR_Rhodpsn	GPR83 TACR1 CMKLR1 GALR2 RHO OR4E2	1.19e-03	692	33	6	IPR000276
Pathway	REACTOME_CYP2E1_REACTIONS	CYP2A6 CYP2A7 CYP2A13	1.28e-06	11	29	3	M27130
Pathway	REACTOME_CYP2E1_REACTIONS	CYP2A6 CYP2A7 CYP2A13	1.70e-06	12	29	3	MM14847
Pathway	REACTOME_FATTY_ACIDS	CYP2A6 CYP2A7 CYP2A13	6.26e-06	18	29	3	MM14841
Pathway	REACTOME_XENOBIOTICS	CYP2A6 CYP2A7 CYP2A13	1.35e-05	23	29	3	M5372
Pathway	REACTOME_XENOBIOTICS	CYP2A6 CYP2A7 CYP2A13	1.75e-05	25	29	3	MM14846
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_TO_DNA_ADDUCTS	CYP2A6 CYP2A13	4.07e-05	5	29	2	M47808
Pathway	REACTOME_SLC_TRANSPORTER_DISORDERS	SLC6A5 NUP188 SLC12A1 SLC4A4	4.75e-05	99	29	4	M27474
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	NPC1 SLC6A5 LIPA SLC12A1 SLC12A2 SLC4A4 ATP10D ATP6V0A4	4.94e-05	681	29	8	MM14985
Pathway	REACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS	SLC12A1 SLC12A2	8.53e-05	7	29	2	M27339
Pathway	REACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS	SLC12A1 SLC12A2	8.53e-05	7	29	2	MM15081
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	NPC1 SLC6A5 LIPA SLC12A1 SLC12A2 SLC4A4 ATP10D ATP6V0A4	8.56e-05	736	29	8	M27287
Pathway	KEGG_DRUG_METABOLISM_OTHER_ENZYMES	CYP2A6 CYP2A7 CYP2A13	1.53e-04	51	29	3	M17726
Pathway	WP_OXIDATION_BY_CYTOCHROME_P450	CYP2A6 CYP2A7 CYP2A13	2.73e-04	62	29	3	M39653
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP2A6 CYP2A7 CYP2A13	3.00e-04	64	29	3	M5650
Pathway	KEGG_RETINOL_METABOLISM	CYP2A6 CYP2A7 CYP2A13	3.00e-04	64	29	3	M9488
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP2A6 CYP2A7 CYP2A13	3.28e-04	66	29	3	MM14839
Pathway	REACTOME_FATTY_ACIDS	CYP2A7 CYP2A13	4.22e-04	15	29	2	M27126
Pathway	KEGG_DRUG_METABOLISM_CYTOCHROME_P450	CYP2A6 CYP2A7 CYP2A13	4.24e-04	72	29	3	M9257
Pathway	REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS	SLC6A5 NUP188 SLC12A1 SLC4A4	4.46e-04	177	29	4	M27476
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	GPR83 CMKLR1 GALR2 RHO	5.38e-04	186	29	4	MM15994
Pathway	WP_DEGRADATION_PATHWAY_OF_SPHINGOLIPIDS_INCLUDING_DISEASES	NPC1 LIPA	5.45e-04	17	29	2	M39638
Pathway	REACTOME_LDL_CLEARANCE	NPC1 LIPA	6.13e-04	18	29	2	MM15565
Pathway	REACTOME_LDL_CLEARANCE	NPC1 LIPA	6.84e-04	19	29	2	M27846
Pathway	REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS	CYP2A6 CYP2A7 CYP2A13	1.24e-03	104	29	3	M738
Pathway	REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS	CYP2A6 CYP2A7 CYP2A13	1.27e-03	105	29	3	MM14842
Pathway	REACTOME_AFLATOXIN_ACTIVATION_AND_DETOXIFICATION	CYP2A6 CYP2A13	1.29e-03	26	29	2	MM15190
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC6A5 SLC12A1 SLC12A2 SLC4A4	1.35e-03	238	29	4	MM15076
Pathway	REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES	SLC12A1 SLC12A2 SLC4A4	1.38e-03	108	29	3	M823
Pathway	REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES	SLC12A1 SLC12A2 SLC4A4	1.42e-03	109	29	3	MM15074
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC6A5 SLC12A1 SLC12A2 SLC4A4	1.59e-03	249	29	4	M5988
Pathway	REACTOME_SIGNALING_BY_GPCR	GPR83 TACR1 CMKLR1 GALR2 DAGLA RHO	1.74e-03	646	29	6	MM14962
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	GPR83 CMKLR1 GALR2 RHO	1.87e-03	260	29	4	M39397
Pathway	KEGG_LYSOSOME	NPC1 LIPA ATP6V0A4	1.92e-03	121	29	3	M11266
Pathway	REACTOME_PLASMA_LIPOPROTEIN_CLEARANCE	NPC1 LIPA	2.20e-03	34	29	2	MM15566
Pathway	REACTOME_PLASMA_LIPOPROTEIN_CLEARANCE	NPC1 LIPA	2.60e-03	37	29	2	M27847
Pathway	REACTOME_SIGNALING_BY_GPCR	GPR83 TACR1 CMKLR1 GALR2 DAGLA RHO	2.65e-03	702	29	6	M746
Pathway	WP_GPCRS_ODORANT	GPR83 CMKLR1 RHO	4.00e-03	157	29	3	MM15872
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	TACR1 CMKLR1 GALR2 RHO	4.41e-03	330	29	4	M18334
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	TACR1 CMKLR1 GALR2 RHO	4.55e-03	333	29	4	MM14963
Pathway	KEGG_VIBRIO_CHOLERAE_INFECTION	SLC12A2 ATP6V0A4	5.47e-03	54	29	2	M17906
Pubmed	Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.	CYP2A6 CYP2A7 CYP2A13	7.78e-10	3	33	3	1417950
Pubmed	Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.	CYP2A6 CYP2A7 CYP2A13	7.78e-10	3	33	3	31645370
Pubmed	Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.	CYP2A6 CYP2A7 CYP2A13	7.78e-10	3	33	3	24045421
Pubmed	Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.	CYP2A6 CYP2A7 CYP2A13	7.78e-10	3	33	3	32987105
Pubmed	Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.	CYP2A6 CYP2A7 CYP2A13	7.78e-10	3	33	3	3346244
Pubmed	Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.	CYP2A6 CYP2A7 CYP2A13	7.78e-10	3	33	3	22217847
Pubmed	Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.	CYP2A6 CYP2A7 CYP2A13	7.78e-10	3	33	3	2765478
Pubmed	Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.	CYP2A6 CYP2A7 CYP2A13	7.78e-10	3	33	3	2415518
Pubmed	Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.	CYP2A6 CYP2A7 CYP2A13	7.78e-10	3	33	3	2733794
Pubmed	A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.	CYP2A6 CYP2A7 CYP2A13	7.78e-10	3	33	3	8297477
Pubmed	Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.	CYP2A6 CYP2A7 CYP2A13	7.78e-10	3	33	3	22890016
Pubmed	Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.	CYP2A6 CYP2A7 CYP2A13	7.78e-10	3	33	3	8188299
Pubmed	Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.	CYP2A6 CYP2A7 CYP2A13	7.78e-10	3	33	3	8484736
Pubmed	Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.	CYP2A6 CYP2A7 CYP2A13	7.78e-10	3	33	3	8250953
Pubmed	The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.	CYP2A6 CYP2A7 CYP2A13	7.78e-10	3	33	3	2703500
Pubmed	Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver.	CYP2A6 CYP2A7 CYP2A13	3.11e-09	4	33	3	9408084
Pubmed	A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.	CYP2A6 CYP2A7 CYP2A13	3.11e-09	4	33	3	7565685
Pubmed	Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP.	CYP2A6 CYP2A7 CYP2A13	3.11e-09	4	33	3	10490589
Pubmed	Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice.	CYP2A6 CYP2A7 CYP2A13	3.11e-09	4	33	3	1970547
Pubmed	A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.	CYP2A6 CYP2A7 CYP2A13	1.55e-08	6	33	3	7668294
Pubmed	Genetic regulation of coumarin hydroxylase activity in mice. Evidence for single locus control on chromosome.	CYP2A6 CYP2A13 OCA2	1.55e-08	6	33	3	447675
Pubmed	Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19.	CYP2A6 CYP2A7 CYP2A13	1.55e-08	6	33	3	8587134
Pubmed	Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.	CYP2A6 CYP2A7 CYP2A13	2.72e-08	7	33	3	9630227
Pubmed	Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster.	CYP2A6 CYP2A7 CYP2A13	2.72e-08	7	33	3	14630516
Pubmed	Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder.	CYP2A6 CYP2A7 CYP2A13	6.51e-08	9	33	3	37838304
Pubmed	Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism.	CYP2A6 CYP2A7 CYP2A13	3.51e-07	15	33	3	29968852
Pubmed	Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.	CYP2A6 CYP2A7 CYP2A13	5.24e-07	17	33	3	27197076
Pubmed	Expression of CYP2A genes in human liver and extrahepatic tissues.	CYP2A7 CYP2A13	8.73e-07	2	33	2	10353262
Pubmed	Expression and alternative splicing of the cytochrome P-450 CYP2A7.	CYP2A6 CYP2A7	8.73e-07	2	33	2	7864805
Pubmed	Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver.	CYP2A6 CYP2A13	8.73e-07	2	33	2	28298240
Pubmed	Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice.	CYP2A6 CYP2A13	8.73e-07	2	33	2	6309775
Pubmed	The Na-K-Cl cotransporters.	SLC12A1 SLC12A2	8.73e-07	2	33	2	9672238
Pubmed	Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.	CYP2A6 CYP2A7	8.73e-07	2	33	2	12325023
Pubmed	Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo.	CYP2A6 CYP2A13	8.73e-07	2	33	2	21418183
Pubmed	Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.	CYP2A6 CYP2A13	8.73e-07	2	33	2	22696418
Pubmed	Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.	CYP2A6 CYP2A13	8.73e-07	2	33	2	22262919
Pubmed	Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice.	CYP2A6 CYP2A13	8.73e-07	2	33	2	30876690
Pubmed	Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment.	NPC1 LIPA	8.73e-07	2	33	2	21697390
Pubmed	CYP2A5 induction and hepatocellular stress: an adaptive response to perturbations of heme homeostasis.	CYP2A6 CYP2A13	8.73e-07	2	33	2	21395539
Pubmed	Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.	CYP2A6 CYP2A13	8.73e-07	2	33	2	25635819
Pubmed	Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions.	CYP2A6 CYP2A13	8.73e-07	2	33	2	12162851
Pubmed	Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh.	CYP2A6 CYP2A13	8.73e-07	2	33	2	1302041
Pubmed	Structural alteration of mouse P450coh by mutation of glycine-207 to proline: spin equilibrium, enzyme kinetics, and heat sensitivity.	CYP2A6 CYP2A13	8.73e-07	2	33	2	8395817
Pubmed	Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice.	CYP2A6 CYP2A13	8.73e-07	2	33	2	25804444
Pubmed	Expression of the basolateral Na-K-Cl cotransporter during mouse nephrogenesis and embryonic development.	SLC12A1 SLC12A2	8.73e-07	2	33	2	16814616
Pubmed	Genetic variation between mice in their metabolism of coumarin and its derivatives.	CYP2A6 CYP2A13	8.73e-07	2	33	2	566237
Pubmed	Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression.	CYP2A6 CYP2A13	8.73e-07	2	33	2	1520280
Pubmed	Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model.	CYP2A6 CYP2A13	8.73e-07	2	33	2	19923441
Pubmed	Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.	CYP2A6 CYP2A13	8.73e-07	2	33	2	23917075
Pubmed	Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression.	CYP2A6 CYP2A13	8.73e-07	2	33	2	12499123
Pubmed	Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5.	CYP2A6 CYP2A13	8.73e-07	2	33	2	30222954
Pubmed	CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.	CYP2A6 CYP2A7	8.73e-07	2	33	2	16636685
Pubmed	Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization.	CYP2A6 CYP2A13	8.73e-07	2	33	2	8611142
Pubmed	Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver.	CYP2A6 CYP2A13	8.73e-07	2	33	2	7543189
Pubmed	Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.	CYP2A6 CYP2A13	8.73e-07	2	33	2	27902773
Pubmed	Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver.	CYP2A6 CYP2A13	8.73e-07	2	33	2	22497566
Pubmed	Molecular cloning and chromosome localization of a putative basolateral Na(+)-K(+)-2Cl- cotransporter from mouse inner medullary collecting duct (mIMCD-3) cells.	SLC12A1 SLC12A2	8.73e-07	2	33	2	7929272
Pubmed	Characterization and regulation of sex-specific mouse steroid hydroxylase genes.	CYP2A6 CYP2A13	8.73e-07	2	33	2	2372744
Pubmed	Coumarin toxicity in different strains of mice.	CYP2A6 CYP2A13	8.73e-07	2	33	2	665441
Pubmed	The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.	CYP2A6 CYP2A7	8.73e-07	2	33	2	2322567
Pubmed	Increased Slc12a1 expression in β-cells and improved glucose disposal in Slc12a2 heterozygous mice.	SLC12A1 SLC12A2	8.73e-07	2	33	2	26400961
Pubmed	Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.	CYP2A6 CYP2A13	8.73e-07	2	33	2	21473878
Pubmed	Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.	CYP2A6 CYP2A13	8.73e-07	2	33	2	24104196
Pubmed	The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.	CYP2A6 CYP2A13	8.73e-07	2	33	2	7581481
Pubmed	Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2.	SLC12A1 SLC12A2	8.73e-07	2	33	2	8640224
Pubmed	The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.	CYP2A6 CYP2A13	8.73e-07	2	33	2	26363552
Pubmed	Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ.	CYP2A6 CYP2A13	8.73e-07	2	33	2	30154104
Pubmed	Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes.	CYP2A6 CYP2A13	8.73e-07	2	33	2	2712571
Pubmed	Molecular genetics of the human cytochrome P450 monooxygenase superfamily.	CYP2A6 CYP2A7 CYP2A13	8.77e-07	20	33	3	9890157
Pubmed	Resveratrol improves health and survival of mice on a high-calorie diet.	CYP2A6 CYP2A7 CYP2A13	1.99e-06	26	33	3	17086191
Pubmed	Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes.	CYP2A6 CYP2A13	2.62e-06	3	33	2	18602936
Pubmed	Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress.	CYP2A6 CYP2A13	2.62e-06	3	33	2	18068688
Pubmed	CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.	CYP2A6 CYP2A7	2.62e-06	3	33	2	11960914
Pubmed	Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA.	CYP2A6 CYP2A13	2.62e-06	3	33	2	3219345
Pubmed	Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to Cyp2b and Coh on mouse chromosome 7.	CYP2A6 CYP2A13	2.62e-06	3	33	2	1973143
Pubmed	Zfp30, a KRAB domain containing zinc finger protein gene, maps to mouse chromosome 7.	CYP2A6 CYP2A13	2.62e-06	3	33	2	7849402
Pubmed	A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression.	CYP2A6 CYP2A13	2.62e-06	3	33	2	21252290
Pubmed	Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress.	CYP2A6 CYP2A13	2.62e-06	3	33	2	25478736
Pubmed	Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.	CYP2A6 CYP2A13	2.62e-06	3	33	2	20840855
Pubmed	Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box site.	CYP2A6 CYP2A13	2.62e-06	3	33	2	17466327
Pubmed	Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway.	CYP2A6 CYP2A13	2.62e-06	3	33	2	22552773
Pubmed	CYP2A7 pseudogene transcript affects CYP2A6 expression in human liver by acting as a decoy for miR-126.	CYP2A6 CYP2A7	2.62e-06	3	33	2	25710939
Pubmed	High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis.	CYP2A6 CYP2A13	2.62e-06	3	33	2	32877213
Pubmed	Limited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital.	CYP2A6 CYP2A13	2.62e-06	3	33	2	11106424
Pubmed	Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family.	SLC12A1 SLC12A2	2.62e-06	3	33	2	8663127
Pubmed	Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation.	CYP2A6 CYP2A13	2.62e-06	3	33	2	24191237
Pubmed	Regulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2.	CYP2A6 CYP2A13	2.62e-06	3	33	2	17303623
Pubmed	Cytosolic sodium regulation in mouse cortical astrocytes and its dependence on potassium and bicarbonate.	SLC12A2 SLC4A4	2.62e-06	3	33	2	30132845
Pubmed	Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse model.	CYP2A6 CYP2A13	2.62e-06	3	33	2	23073733
Pubmed	Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations.	NPC1 LIPA	2.62e-06	3	33	2	21289032
Pubmed	Analysis of RNA-protein interactions of mouse liver cytochrome P4502A5 mRNA.	CYP2A6 CYP2A13	5.23e-06	4	33	2	10215609
Pubmed	Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome.	SLC12A1 SLC12A2	5.23e-06	4	33	2	21972418
Pubmed	Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5.	CYP2A6 CYP2A13	5.23e-06	4	33	2	24494203
Pubmed	Altered expression of regulators of the cortical chloride transporters NKCC1 and KCC2 in schizophrenia.	SLC12A1 SLC12A2	5.23e-06	4	33	2	20819979
Pubmed	Evidence for induced microsomal bilirubin degradation by cytochrome P450 2A5.	CYP2A6 CYP2A13	5.23e-06	4	33	2	16183037
Pubmed	Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity.	SLC12A1 SLC12A2	5.23e-06	4	33	2	22989884
Pubmed	The genes for mouse salivary androgen-binding protein (ABP) subunits alpha and gamma are located on chromosome 7.	CYP2A6 CYP2A13	5.23e-06	4	33	2	3569880
Pubmed	DNA sequence polymorphism in an androgen-regulated gene is associated with alteration in the encoded RNAs.	CYP2A6 CYP2A13	5.23e-06	4	33	2	6188152
Pubmed	Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models.	CYP2A6 CYP2A13	5.23e-06	4	33	2	22228748
Pubmed	Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China.	CYP2A6 CYP2A13	8.72e-06	5	33	2	19303722
Interaction	CYP2A7 interactions	CYP2A6 CYP2A7 CYP2A13	4.00e-09	3	33	3	int:CYP2A7
Interaction	YIPF3 interactions	NPC1 SLC6A5 TACR1 CMKLR1 REEP4 TMEM161B	5.13e-07	186	33	6	int:YIPF3
Interaction	SIGMAR1 interactions	NPC1 SLC6A5 TACR1 CMKLR1	3.88e-05	117	33	4	int:SIGMAR1
Interaction	CYP2A13 interactions	CYP2A7 CYP2A13	3.88e-05	6	33	2	int:CYP2A13
Interaction	CYP2A6 interactions	CYP2A6 CYP2A7	9.29e-05	9	33	2	int:CYP2A6
Cytoband	19q13.2	CYP2A6 CYP2A7 CYP2A13	2.26e-04	164	33	3	19q13.2
GeneFamily	Cytochrome P450 family 2	CYP2A6 CYP2A7 CYP2A13	1.48e-05	35	25	3	1001
GeneFamily	Lipases\|Arylacetamide deacetylase family	LIPA DAGLA	4.17e-04	22	25	2	464
GeneFamily	Solute carriers	SLC6A5 SLC12A1 SLC12A2 SLC4A4	1.97e-03	395	25	4	752
Coexpression	GSE5542_UNTREATED_VS_IFNA_AND_IFNG_TREATED_EPITHELIAL_CELLS_6H_DN	NPC1 ITPRIP TACR1 SLC4A4 ATP10D	4.79e-06	199	33	5	M6519
Coexpression	WENG_POR_DOSAGE	CYP2A6 CYP2A7 CYP2A13	7.21e-06	30	33	3	MM1199
Coexpression	WENG_POR_TARGETS_LIVER_UP	CYP2A6 CYP2A7 CYP2A13	4.08e-05	53	33	3	MM1203
Coexpression	BENPORATH_ES_WITH_H3K27ME3	SLC6A5 CYP2A6 CYP2A7 CYP2A13 OCA2 TACR1 CDH4 GALR2	5.61e-05	1115	33	8	M10371
Coexpression	UEDA_PERIFERAL_CLOCK	NPC1 CYP2A6 CYP2A7 CYP2A13	7.06e-05	177	33	4	MM1145
Coexpression	TABULA_MURIS_SENIS_KIDNEY_BRUSH_CELL_AGEING	CYP2A6 CYP2A7 CYP2A13	1.15e-04	75	33	3	MM3718
CoexpressionAtlas	kidney_adult_RenalCortexMixed_Std_k-means-cluster#2_top-relative-expression-ranked_200	SLC12A1 SLC4A4 ATP6V0A4	1.64e-05	33	32	3	gudmap_kidney_adult_RenalCortexMixed_Std_k2_200
CoexpressionAtlas	kidney_adult_JuxtaGlom_Ren1_top-relative-expression-ranked_500	CFH CYP2A13 LIPA SLC12A1 SLC4A4 ATP6V0A4	2.58e-05	400	32	6	gudmap_kidney_adult_JuxtaGlom_Ren1_500
CoexpressionAtlas	kidney_adult_JuxtaGlom_Ren1_Captopr_top-relative-expression-ranked_500	CFH CYP2A13 SLC12A1 SLC12A2 SLC4A4 ATP6V0A4	2.80e-05	406	32	6	gudmap_kidney_adult_JuxtaGlom_Ren1_Captopr_500
CoexpressionAtlas	kidney_adult_RenalCortexMixed_Std_k-means-cluster#2_top-relative-expression-ranked_1000	CYP2A13 LIPA SLC12A1 SLC4A4 ATP6V0A4	5.69e-05	279	32	5	gudmap_kidney_adult_RenalCortexMixed_Std_k2_1000
CoexpressionAtlas	kidney_adult_RenalCortexMixed_Std_k-means-cluster#4_top-relative-expression-ranked_500	CYP2A13 SLC12A1 SLC4A4 ATP6V0A4	5.96e-05	142	32	4	gudmap_kidney_adult_RenalCortexMixed_Std_k4_500
CoexpressionAtlas	kidney_adult_CortVasc_Tie2_k-means-cluster#4_top-relative-expression-ranked_500	LIPA SLC12A1 SLC4A4 ATP6V0A4	6.29e-05	144	32	4	gudmap_kidney_adult_CortVasc_Tie2_k4_500
CoexpressionAtlas	kidney_adult_JuxtaGlom_Ren1_Captopr_top-relative-expression-ranked_200	CFH SLC12A1 SLC4A4 ATP6V0A4	8.80e-05	157	32	4	gudmap_kidney_adult_JuxtaGlom_Ren1_Captopr_200
CoexpressionAtlas	kidney_adult_CortVasc_Tie2_k-means-cluster#1_top-relative-expression-ranked_1000	CYP2A13 LIPA SLC12A1 SLC4A4 ATP6V0A4	9.94e-05	314	32	5	gudmap_kidney_adult_CortVasc_Tie2_k1_1000
CoexpressionAtlas	kidney_adult_JuxtaGlom_Ren1_Captopr_top-relative-expression-ranked_1000	CFH CYP2A13 LIPA SLC12A1 SLC12A2 SLC4A4 ATP6V0A4	1.30e-04	778	32	7	gudmap_kidney_adult_JuxtaGlom_Ren1_Captopr_1000
CoexpressionAtlas	kidney_adult_RenalCapsule_k-means-cluster#4_top-relative-expression-ranked_200	SLC4A4 ATP6V0A4	1.44e-04	12	32	2	gudmap_kidney_adult_RenalCapsule_k4_200
CoexpressionAtlas	kidney_adult_JuxtaGlom_Ren1_k-means-cluster#1_top-relative-expression-ranked_200	SLC12A1 SLC4A4 ATP6V0A4	2.03e-04	76	32	3	gudmap_kidney_adult_JuxtaGlom_Ren1_k1_200
CoexpressionAtlas	kidney_adult_JuxtaGlom_Ren1_Captopr_top-relative-expression-ranked_100	CFH SLC12A1 SLC4A4	2.11e-04	77	32	3	gudmap_kidney_adult_JuxtaGlom_Ren1_Captopr_100
CoexpressionAtlas	kidney_adult_CortVasc_Tie2_top-relative-expression-ranked_1000	ACER2 CYP2A13 LIPA CALR3 SLC12A1 SLC4A4 ATP6V0A4	2.19e-04	846	32	7	gudmap_kidney_adult_CortVasc_Tie2_1000
CoexpressionAtlas	kidney_adult_JuxtaGlom_Ren1_top-relative-expression-ranked_100	SLC12A1 SLC4A4 ATP6V0A4	2.36e-04	80	32	3	gudmap_kidney_adult_JuxtaGlom_Ren1_100
CoexpressionAtlas	kidney_adult_RenalCortexMixed_Std_k-means-cluster#1_top-relative-expression-ranked_100	SLC12A1 SLC4A4	2.61e-04	16	32	2	gudmap_kidney_adult_RenalCortexMixed_Std_k1_100
CoexpressionAtlas	kidney_adult_CortVasc_Tie2_top-relative-expression-ranked_500	ACER2 LIPA SLC12A1 SLC4A4 ATP6V0A4	3.71e-04	417	32	5	gudmap_kidney_adult_CortVasc_Tie2_500
CoexpressionAtlas	kidney_adult_JuxtaGlom_Ren1_Captopr_k-means-cluster#2_top-relative-expression-ranked_1000	CYP2A13 LIPA SLC12A1 SLC4A4 ATP6V0A4	4.79e-04	441	32	5	gudmap_kidney_adult_JuxtaGlom_Ren1_Captopr_k2_1000
CoexpressionAtlas	kidney_P0_JuxtaGlom_Ren1_top-relative-expression-ranked_500	CFH SLC12A1 SLC12A2 SLC4A4 ATP6V0A4	5.57e-04	456	32	5	gudmap_kidney_P0_JuxtaGlom_Ren1_500
CoexpressionAtlas	kidney_adult_JuxtaGlom_Ren1_Captopr_k-means-cluster#1_top-relative-expression-ranked_100	SLC12A1 SLC4A4	6.46e-04	25	32	2	gudmap_kidney_adult_JuxtaGlom_Ren1_Captopr_k1_100
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-Club\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CFH CYP2A6 CYP2A7 CYP2A13 SLC4A4	3.20e-07	196	33	5	4e4c632db73b1340d80bf40a7657cb4821084d3c
ToppCell	Club_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	CFH CYP2A6 CYP2A13 TACR1	6.89e-06	167	33	4	dbdaaeb3bd9139cb008d9fe24ec031fc5628f136
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CFH CYP2A13 TACR1 SLC4A4	7.92e-06	173	33	4	464267a2ff3f5c387b6c9c6fa4dab135a221f448
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A6 CYP2A7 CYP2A13 SLC4A4	8.10e-06	174	33	4	42f2ba54b4ea4c62482582b0ccdadffae0a5eb4a
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TACR1 PKHD1L1 ATP6V0A4 RHO	8.29e-06	175	33	4	59249c9e83952d7277010e7be3c779e26399eb5d
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TACR1 PKHD1L1 ATP6V0A4 RHO	8.29e-06	175	33	4	b35cc1357495f2a03a6500f807c6e6f8c877734d
ToppCell	nucseq-Epithelial-Epithelial_Airway-Secretory/RAS\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFH CYP2A7 TACR1 SLC4A4	8.67e-06	177	33	4	779ba86f53650772755b52460be03f18bb204e55
ToppCell	nucseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFH CYP2A7 TACR1 SLC4A4	8.67e-06	177	33	4	0f210cfb61b873c5fd77dc17eadf4d017306500e
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CFH CYP2A13 TACR1 SLC4A4	9.67e-06	182	33	4	3f1a666fe27dd7529c114539ed5f6b8ca585c875
ToppCell	facs-Lung-nan-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACER2 CMKLR1 SLC4A4 PKHD1L1	9.88e-06	183	33	4	12e876d6205af8aad74265c668b5e95b9e7487f3
ToppCell	facs-Heart-LA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACER2 CFH PKHD1L1 CDH4	1.03e-05	185	33	4	1ecfca049c0c1110fd1b2256db7cb7abda6afb04
ToppCell	facs-Heart-LA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACER2 CFH PKHD1L1 CDH4	1.03e-05	185	33	4	b6df1412b579d40ed5df806f9c54bd1fbb9a1e15
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH CYP2A6 CYP2A7 DAGLA	1.08e-05	187	33	4	f5a202d5f8eb57b57d80815ce98774e04c387383
ToppCell	18-Distal-Epithelial-Secretory_progenitor\|Distal / Age, Tissue, Lineage and Cell class	CFH CYP2A6 CYP2A7 CYP2A13	1.19e-05	192	33	4	9fae988ecd2ef1231bfd42a678a4903517694cbe
ToppCell	Club_cells\|World / lung cells shred on cell class, cell subclass, sample id	CFH CYP2A6 CYP2A7 SLC4A4	1.22e-05	193	33	4	9d3165dc5763a07a7d873f497624d9d6528fa2db
ToppCell	Club_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	CFH CYP2A6 CYP2A7 SLC4A4	1.22e-05	193	33	4	6582c0367052b9d10fb629c383ee0c55872afd2d
ToppCell	Goblet\|World / shred by cell class for turbinate	CYP2A6 CYP2A13 SLC12A2 SLC4A4	1.24e-05	194	33	4	03b62e7cff5e7a6e7bd7d9dda273c74bf9c1f42e
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH CYP2A13 SLC12A2 SLC4A4	1.27e-05	195	33	4	576142b4e75457c0973051bccc4163bd624496af
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ACER2 CFH ITPRIP TACR1	1.27e-05	195	33	4	6bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH CYP2A13 SLC12A2 SLC4A4	1.27e-05	195	33	4	8f151066ad3ebd9661ea0b733f03c2ce1518f9ad
ToppCell	Epithelial_cells-Club_cells\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	CFH CYP2A6 CYP2A7 SLC4A4	1.27e-05	195	33	4	b758676abfc4e6930b696d270ecc0ea461b87a54
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH CYP2A13 SLC12A2 SLC4A4	1.27e-05	195	33	4	2a9a36df1dbc4eac77a8ddbe939ec8a8d6c41464
ToppCell	normal_Lung-Epithelial_cells-Club\|normal_Lung / Location, Cell class and cell subclass	CYP2A6 CYP2A7 CYP2A13 SLC4A4	1.27e-05	195	33	4	b46544ad5af04f4dbc2643637caa3d2d50d922ae
ToppCell	normal_Lung-Epithelial_cells-Club\|Epithelial_cells / Location, Cell class and cell subclass	CFH CYP2A6 CYP2A7 CYP2A13	1.35e-05	198	33	4	a9d0109ca05eb3e9c588f9677ec471dd5c092a75
ToppCell	Biopsy_Control_(H.)-Epithelial-SCGB3A2+_SCGB1A1+\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	CFH CYP2A6 CYP2A7 CYP2A13	1.35e-05	198	33	4	a3d4b6e4259ded2193d94d2ff6d48cf67214fc35
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX-Club\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	CYP2A6 CYP2A7 CYP2A13 SLC4A4	1.37e-05	199	33	4	111cfd589ec6795075d8d88d7664bfb23eba5bf6
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Club-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CYP2A6 CYP2A7 CYP2A13 SLC4A4	1.37e-05	199	33	4	d583290a1d288b749ad17bc501c1487268c6551c
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CYP2A13 TACR1 SLC4A4 ATP6V0A4	1.37e-05	199	33	4	527aae1d9d37a50deefc01fc0c064a53673681bd
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Club\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CYP2A6 CYP2A7 CYP2A13 SLC4A4	1.37e-05	199	33	4	2b17694cffbec28a2c8f165dfcff6bab94aa0f4c
ToppCell	Biopsy_Control_(H.)-Epithelial-MUC5B+\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	CFH CYP2A13 TACR1 SLC4A4	1.37e-05	199	33	4	4ab45996e6bca406c77895a5998982b8ab1cf210
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Cbln1_(VTA_(dorsal_VTA))-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SLC12A1 KCNG3 ATP6V0A4	1.45e-05	64	33	3	1b75c6ea17ba7efa83ffe8ae07a863abcdad542c
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Cbln1_(VTA_(dorsal_VTA))\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SLC12A1 KCNG3 ATP6V0A4	1.45e-05	64	33	3	275b4c418dc631a0925d6516cee6bf217cb7240a
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Ductal_and_Mucinous_Carcinoma-1\|TCGA-Breast / Sample_Type by Project: Shred V9	CYP2A6 CYP2A7 CYP2A13	1.67e-04	145	33	3	1e52e3c615b49e7388cd58a04e74cafac9552447
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CFH TACR1 SLC4A4	1.91e-04	152	33	3	1b2a39ae159e79f1fb18d6d164bd7acab5299fca
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CMKLR1 GALR2 DAGLA	1.99e-04	154	33	3	ea5d0da5dd8ccfc19969aec35f044db77d589f54
ToppCell	Club_cells-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	CFH CYP2A6 CYP2A13	2.39e-04	164	33	3	4e25e6362ef793b08de2f4d1dccb6b1fc9c072a5
ToppCell	COVID-19-lung-Mesothelial\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CFH SLC4A4 PKHD1L1	2.39e-04	164	33	3	83303e2ba52008391b8dc3fae8225ab5bcb20063
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A7 CYP2A13 SLC4A4	2.48e-04	166	33	3	60060b03f2abfa3cc08107ab5a9f578e60e4ae16
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A7 CYP2A13 SLC4A4	2.48e-04	166	33	3	ec9161d388db5a257b8d125c14f9dd911d5d5d4a
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A7 CYP2A13 SLC4A4	2.48e-04	166	33	3	4586d6725403f879fc96f67be579022587ce1906
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A13 SLC12A2 SLC4A4	2.52e-04	167	33	3	31633899aae852873a4887e72c621474b0a51a33
ToppCell	Adult-Epithelial-lung_goblet_cell-D122\|Adult / Lineage, Cell type, age group and donor	CFH TACR1 SLC4A4	2.52e-04	167	33	3	6efbb2ef6adc8da5dd67210969f825f5cc8ed022
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-Goblet-Goblet\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYP2A7 CYP2A13 SLC4A4	2.71e-04	171	33	3	25c1979e972c959e1ce4c57804f976f53a247ad7
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	OCA2 LIPA RHO	2.71e-04	171	33	3	9e00c8191ca9d52151a49baf39f8581cb176fb76
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-Goblet\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYP2A7 CYP2A13 SLC4A4	2.71e-04	171	33	3	fe27bf581c75ef33c2848878e51ed16b275a4c8e
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A13 SLC12A2 SLC4A4	2.80e-04	173	33	3	e8afef5ae68983eb8d6515b43952636a47e9d3d4
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A13 SLC12A2 SLC4A4	2.80e-04	173	33	3	3aa1d28d4814798a772808ed29e1dbbdf92abd03
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	REEP4 CDH4 DAGLA	2.80e-04	173	33	3	ab6d3507301038f944ad59ccd848b5e6eeb76d04
ToppCell	Basal_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	CFH GPR83 CYP2A13	2.85e-04	174	33	3	a0060be3940043015dcc49a5157de5541aed24a1
ToppCell	10x5'-bone_marrow-Myeloid_Mac-Intestinal_macrophages\|bone_marrow / Manually curated celltypes from each tissue	LIPA GALR2 DAGLA	2.85e-04	174	33	3	0746344d62aa7ab77c378e9d5a9f9238e741a76b
ToppCell	droplet-Marrow-nan-18m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH PIGL SLC12A2	2.85e-04	174	33	3	55cc8300489d11322724159ec7d0e1d32a702e91
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A6 SLC12A2 SLC4A4	2.85e-04	174	33	3	3f0a5ce074675d57d479fa069385a1b3071e884e
ToppCell	356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)\|356C / Donor, Lineage, Cell class and subclass (all cells)	CFH CYP2A13 SLC4A4	2.90e-04	175	33	3	4bfae78ac3a2cb9404382aae96d291504a9cfa14
ToppCell	356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	CFH CYP2A13 SLC4A4	2.90e-04	175	33	3	af9c5104c86231cfdb93a0f7d7032379efaa009e
ToppCell	Club_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	CFH CYP2A6 SLC4A4	2.95e-04	176	33	3	88c4ed0ab4a4ede8cad21385d799b723b5786cd9
ToppCell	3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Differentiating_glia\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GPR83 CDH4 DAGLA	2.99e-04	177	33	3	0417460bdb012bc43d7254377fa53d79cdab3f34
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CYP2A6 CYP2A7 SLC12A2	3.04e-04	178	33	3	f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCell	Adult-Epithelial-club_cell-D122\|Adult / Lineage, Cell type, age group and donor	CFH CYP2A6 CYP2A7	3.04e-04	178	33	3	35a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCell	P28-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CFH PKHD1L1 ATP6V0A4	3.04e-04	178	33	3	1e05bc26591fea16e29bcfc5f538dda1dc427f05
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NPC1 KCNG3 ATP6V0A4	3.09e-04	179	33	3	e6ae070b4c52ba08167c7d64ea4cfbac0454c1bf
ToppCell	metastatic_Brain-Endothelial_cells-Lymphatic_ECs\|metastatic_Brain / Location, Cell class and cell subclass	NUP188 ATP10D TMEM161B	3.09e-04	179	33	3	56fe381ffbaba3a4f2f587a3e367b0d11fbd4a2a
ToppCell	10x5'-Lung-Lymphocytic_B_plasma-Plasmablasts\|Lung / Manually curated celltypes from each tissue	CKAP5 CALR3 PKHD1L1	3.09e-04	179	33	3	3fa75eec3e86fd1797eaa33362257df7f9b2a0bf
ToppCell	Control-Epithelial-Goblet\|Control / Disease state, Lineage and Cell class	CFH CYP2A13 SLC4A4	3.15e-04	180	33	3	5293d23b8b8ea587239ffde561b70bad01632521
ToppCell	droplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ACER2 SLC4A4 PKHD1L1	3.20e-04	181	33	3	2c44c41b4e8a75ebdbaeb0c6cc5a03f17c44758c
ToppCell	Club-club-8\|World / Class top	CFH SLC12A2 SLC4A4	3.25e-04	182	33	3	8111d917e588008d947021460ddf8f1e7ae1337a
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GALR2 DAGLA ATP6V0A4	3.25e-04	182	33	3	a1c0e4090a9e7aa4941a40c817d178de144888b6
ToppCell	COVID-19-kidney-Mito-rich_EC\|kidney / Disease (COVID-19 only), tissue and cell type	ITPRIP CYP2A7 CMKLR1	3.30e-04	183	33	3	3c4153479fc4ab2d073d92cee120480015555914
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACER2 CFH PKHD1L1	3.30e-04	183	33	3	6c4a09c02e30e1f24dde39f8cb8c5b453826ee2e
ToppCell	Control-Epithelial-Goblet\|Epithelial / Disease state, Lineage and Cell class	CFH CYP2A13 TACR1	3.30e-04	183	33	3	bdd461349a1ef43a015843937d26e8d3571ecc22
ToppCell	droplet-Kidney-nan-18m\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIPA SLC4A4 ATP6V0A4	3.35e-04	184	33	3	e02859bbac36dbbd55d7ae8cb5e46b764d7c6381
ToppCell	Control-Epithelial-Club\|Epithelial / Disease state, Lineage and Cell class	CYP2A6 CYP2A7 CYP2A13	3.41e-04	185	33	3	6814b3c94c7558443c038a227b5c8563d2cfeac4
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Degenerative_Cortical_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NPC1 KCNG3 ATP6V0A4	3.41e-04	185	33	3	9438097e94219c1db922b8507e3a29106d32a923
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	NPC1 UBR2 TMEM161B	3.41e-04	185	33	3	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	NPC1 UBR2 TMEM161B	3.46e-04	186	33	3	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	facs-Heart-LA-24m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACER2 CFH PKHD1L1	3.52e-04	187	33	3	7b13c3b67d66f3afb410141d5471c9e78a4d8623
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH CMKLR1 PKHD1L1	3.52e-04	187	33	3	4e553721fa5598cb211f44e3226280b7e6885484
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH CMKLR1 PKHD1L1	3.52e-04	187	33	3	d36e7fc6125e7a4310499365022d38f34b757a73
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH CMKLR1 PKHD1L1	3.52e-04	187	33	3	827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell	facs-Heart-LA-24m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACER2 CFH PKHD1L1	3.52e-04	187	33	3	d9943e65eedab73d141eae524e2411653a751705
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-Proximal_secretory_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CFH CYP2A6 CYP2A13	3.57e-04	188	33	3	07705bed928683470a52c8ccfa40ffb9a0971318
ToppCell	facs-Heart-RA-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACER2 CFH CDH4	3.57e-04	188	33	3	4ddb11a90bf3baa7237bde304db44dfcc56aed52
ToppCell	facs-Heart-RA-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACER2 CFH CDH4	3.57e-04	188	33	3	e47e66906922d5c69b1aafe28face0787d3fc563
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFH ITPRIP TACR1	3.57e-04	188	33	3	a37edd8f9e4a4e336b5acbb0407d3d275975cee8
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ACER2 CFH TACR1	3.63e-04	189	33	3	6463890d8dbee4bc198f91628a5f784970de786a
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|kidney / Disease (COVID-19 only), tissue and cell type	ACER2 CFH TACR1	3.68e-04	190	33	3	1519f34d31fe0817184c5865a0bc9f0cb479b1a4
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACER2 CFH PKHD1L1	3.68e-04	190	33	3	6f71a9f74af7cd9a674753cfc9833ebe5bba0fa2
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.4\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A7 CYP2A13 SLC4A4	3.74e-04	191	33	3	e96184aee03175fd9f1da11fa2b89d95ba58b817
ToppCell	Children_(3_yrs)-Epithelial-club_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CFH CYP2A6 CYP2A7	3.74e-04	191	33	3	23776c7302cead3881b39127398f3b3e0d27885e
ToppCell	IPF-Epithelial-Goblet\|Epithelial / Disease state, Lineage and Cell class	NPC1 TACR1 SLC4A4	3.74e-04	191	33	3	267e1192aaec468c1a59eb24848b37e0e18cbc44
ToppCell	droplet-Heart-HEART-1m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACER2 PKHD1L1 CDH4	3.74e-04	191	33	3	4bfdf44d4402a42530d30c89d94946acdda4321b
ToppCell	IPF-Epithelial-Club\|World / Disease state, Lineage and Cell class	CYP2A6 CYP2A7 SLC4A4	3.74e-04	191	33	3	3c88a6f1d74bb3b9173cd0ea3a63c6d9570e3954
ToppCell	droplet-Heart\|droplet / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACER2 CFH LIPA	3.80e-04	192	33	3	67a7e07a11091120edbccf739836235c422ec9c6
ToppCell	NS-critical-d_16-33-Epithelial-Secretory-diff\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CYP2A7 CYP2A13 SLC12A2	3.80e-04	192	33	3	02b11233b4da2d85b96498b3c6e22e3a31b3d049
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-G_(Club-Clara_cells)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	CFH CYP2A13 TACR1	3.80e-04	192	33	3	c7c232545fad8ad327ab94bd0def8dc5daacd03d
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-Club\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CFH CYP2A13 SLC4A4	3.80e-04	192	33	3	044c7ae56da17cacf2705efa8ac2c8aeba6cfeee
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1\|TCGA-Endometrium / Sample_Type by Project: Shred V9	CKAP5 NUP188 SLC12A2	3.86e-04	193	33	3	c2673d86f7d7b849788036032a93a6d136a70040
ToppCell	PND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NPC1 SLC12A2 ATP6V0A4	3.86e-04	193	33	3	1fdfe08b0c82248545c29b504ac259b093fde29b
ToppCell	343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CFH CYP2A13 TACR1	3.86e-04	193	33	3	8ede7038a222c7e7ecaf7e86520823cf606cbee7
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CFH OCA2 CDH4	3.86e-04	193	33	3	9f69edc97b868d23998abc98928a2e89a885ef8a
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A6 CYP2A7 CYP2A13	3.86e-04	193	33	3	605fc2a25ed6846fb283b2918cfed98df6039d6b
Drug	2'-methoxyacetophenone	CYP2A6 CYP2A7 CYP2A13	2.77e-09	3	33	3	CID000068481
Drug	N-nitrosomethylaniline	CYP2A6 CYP2A7 CYP2A13	9.99e-07	14	33	3	CID000011957
Drug	nicotine imine	CYP2A6 CYP2A13	2.04e-06	2	33	2	ctd:C034629
Drug	propargyl ether	CYP2A6 CYP2A13	2.04e-06	2	33	2	ctd:C531209
Drug	alpha-nicotyrine	CYP2A6 CYP2A13	2.04e-06	2	33	2	ctd:C008615
Drug	Hempa	CYP2A6 CYP2A13	2.04e-06	2	33	2	ctd:D006492
Drug	N-nitrosoguvacoline	CYP2A6 CYP2A13	2.04e-06	2	33	2	ctd:C036676
Drug	8(9)-EET	CYP2A6 CYP2A7 CYP2A13 SLC12A2	2.96e-06	69	33	4	CID000001901
Drug	NSC35549	CYP2A6 CYP2A7 CYP2A13	4.19e-06	22	33	3	CID000411697
Drug	bromide;iodide	SLC12A1 SLC12A2	6.11e-06	3	33	2	CID009907214
Drug	C14845	CYP2A6 CYP2A7 CYP2A13	7.92e-06	27	33	3	CID011954064
Drug	BP-9,10-oxide	CYP2A6 CYP2A7 CYP2A13	7.92e-06	27	33	3	CID000037456
Drug	Brn 4136738	CYP2A6 CYP2A7 CYP2A13	7.92e-06	27	33	3	CID000050331
Drug	14(15)-EpETrE	CYP2A6 CYP2A7 CYP2A13 SLC12A2	8.18e-06	89	33	4	CID000001431
Drug	9-OH-BaP-4,5-oxide	CYP2A6 CYP2A7 CYP2A13	8.87e-06	28	33	3	CID000115064
Drug	parathion	CKAP5 CYP2A6 CYP2A7 CYP2A13	8.94e-06	91	33	4	CID000000991
Drug	aspirin, USP; Up 200; 100uM; PC3; HT_HG-U133A	OCA2 TACR1 NUP188 GALR2 DAGLA	9.21e-06	198	33	5	4428_UP
Drug	AC1L1BEQ	CYP2A6 CYP2A7 CYP2A13 SLC12A2	9.75e-06	93	33	4	CID000001407
Drug	11-H-14,15-EETA	CYP2A6 CYP2A7 CYP2A13	1.10e-05	30	33	3	CID011954058
Drug	glycine methyl ester	NPC1 SLC6A5 OCA2	1.10e-05	30	33	3	CID000069221
Drug	19-hydroxytestosterone	CYP2A6 CYP2A7 CYP2A13	1.10e-05	30	33	3	CID000150968
Drug	NMPA	CYP2A6 CYP2A13	1.22e-05	4	33	2	CID000132101
Drug	N'-nitrosoanatabine	CYP2A6 CYP2A13	1.22e-05	4	33	2	ctd:C032978
Drug	BP-7,8-oxide	CYP2A6 CYP2A7 CYP2A13	1.34e-05	32	33	3	CID000037455
Drug	12(13)-EpOME	CYP2A6 CYP2A7 CYP2A13	1.61e-05	34	33	3	CID000001416
Drug	TCEO	CYP2A6 CYP2A7 CYP2A13	1.61e-05	34	33	3	CID000028167
Drug	AC1O5XSP	CYP2A6 CYP2A7 CYP2A13	1.61e-05	34	33	3	CID006442739
Drug	AC1L1CJI	CYP2A6 CYP2A7 CYP2A13	1.76e-05	35	33	3	CID000001929
Drug	15-H-11,12-EETA	CYP2A6 CYP2A7 CYP2A13	1.92e-05	36	33	3	CID011954042
Drug	AC1L3NGJ	CYP2A6 CYP2A7 CYP2A13	1.92e-05	36	33	3	CID000092121
Drug	hexamethylphosphoramide	CYP2A6 CYP2A7 CYP2A13	1.92e-05	36	33	3	CID000012679
Drug	Quinethazone	SLC12A1 SLC12A2	2.03e-05	5	33	2	DB01325
Drug	N-methyl-N-2-(methylsulfinyl)ethylpropionic acid amide	CYP2A6 CYP2A13	2.03e-05	5	33	2	ctd:C062567
Drug	benzyl selenocyanate	CYP2A6 CYP2A13	2.03e-05	5	33	2	ctd:C054108
Drug	Bumetanide	SLC12A1 SLC12A2	2.03e-05	5	33	2	DB00887
Drug	3 -hydroxypregn-5-en-20-one	NPC1 CYP2A6 CYP2A7 CYP2A13 LIPA	2.24e-05	238	33	5	CID000001027
Drug	11,14,15-THET	CYP2A6 CYP2A7 CYP2A13	2.45e-05	39	33	3	CID006439531
Drug	acenaphthene-1-ol	CYP2A6 CYP2A13	3.04e-05	6	33	2	ctd:C023723
Drug	AC1L196J	CYP2A6 CYP2A13	3.04e-05	6	33	2	CID000000415
Drug	menthofuran	CYP2A6 CYP2A13	3.04e-05	6	33	2	ctd:C054487
Drug	Potassium Chloride	SLC12A1 SLC12A2	3.04e-05	6	33	2	DB00761
Drug	N'-nitrosoanabasine	CYP2A6 CYP2A13	3.04e-05	6	33	2	ctd:C010257
Drug	11,12,15-trihydroxyeicosatrienoic acid	CYP2A6 CYP2A7 CYP2A13	3.06e-05	42	33	3	CID006439610
Drug	barium chloride dihydrate	GPR83 SLC12A1 SLC12A2	3.29e-05	43	33	3	CID000025157
Drug	polybrominated biphenyl	CYP2A6 CYP2A7 CYP2A13	3.53e-05	44	33	3	CID000042948
Drug	naphthalene-1,2-dihydrodiol	CYP2A6 CYP2A7 CYP2A13	3.78e-05	45	33	3	CID000000362
Drug	cholestatrienol	NPC1 RHO	4.26e-05	7	33	2	CID000171103
Drug	acenaphthene	CYP2A6 CYP2A13	4.26e-05	7	33	2	ctd:C042552
Drug	C14802	CYP2A6 CYP2A7 CYP2A13	4.31e-05	47	33	3	CID011954053
Drug	aminoglutethimide	NPC1 CYP2A6 CYP2A7 CYP2A13	4.48e-05	137	33	4	CID000002145
Drug	C14800	CYP2A6 CYP2A7 CYP2A13	4.59e-05	48	33	3	CID011954051
Drug	nitro-L	CYP2A6 CYP2A7 CYP2A13	4.59e-05	48	33	3	CID000006849
Drug	19-HETE	CYP2A6 CYP2A7 CYP2A13	4.88e-05	49	33	3	CID006439528
Drug	bromobenzene-3,4-oxide	CYP2A6 CYP2A7 CYP2A13	4.88e-05	49	33	3	CID000108121
Drug	bromobenzene-2,3-oxide	CYP2A6 CYP2A7 CYP2A13	5.19e-05	50	33	3	CID003036760
Drug	6-hydroxymelatonin	CYP2A6 CYP2A7 CYP2A13	5.19e-05	50	33	3	CID000001864
Drug	1,1-dichloroethylene epoxide	CYP2A6 CYP2A7 CYP2A13	5.19e-05	50	33	3	CID000119521
Drug	naphthalene epoxide	CYP2A6 CYP2A7 CYP2A13	5.51e-05	51	33	3	CID000108063
Drug	mepivacaine	CYP2A6 CYP2A7 CYP2A13	5.51e-05	51	33	3	CID000004062
Drug	Elvis	OCA2 SLC12A2	5.67e-05	8	33	2	CID003083357
Drug	9-hydroxybenzo(a)pyrene	CYP2A6 CYP2A7 CYP2A13	6.19e-05	53	33	3	CID000028598
Drug	dichloroacetaldehyde	CYP2A6 CYP2A7 CYP2A13	6.54e-05	54	33	3	CID000006576
Drug	chloroacetyl chloride	CYP2A6 CYP2A7 CYP2A13	6.91e-05	55	33	3	CID000006577
Drug	H atom	CYP2A6 SLC4A4 ATP6V0A4 RHO	7.07e-05	154	33	4	CID005362549
Drug	N-nitrosoguvacoline	CYP2A6 CYP2A13	7.29e-05	9	33	2	CID000062103
Drug	3-(methylnitrosamino)propionaldehyde	CYP2A6 CYP2A13	7.29e-05	9	33	2	CID000098533
Drug	acenaphthylene	CYP2A6 CYP2A13	7.29e-05	9	33	2	ctd:C042553
Drug	potassium	SLC6A5 ERG28 SLC12A1 SLC12A2 SLC4A4 KCNG3 GALR2 ATP6V0A4	7.42e-05	1008	33	8	CID000000813
Drug	1,2-dihydroxynaphthalene	CYP2A6 CYP2A7 CYP2A13	7.70e-05	57	33	3	CID000011318
Drug	bromoacetaldehyde	CYP2A6 CYP2A7 CYP2A13	8.11e-05	58	33	3	CID000105131
Drug	1,1-dichloroethylene	CYP2A6 CYP2A7 CYP2A13	8.97e-05	60	33	3	CID000006366
Drug	paraoxon	CYP2A6 CYP2A7 CYP2A13 LIPA	9.02e-05	164	33	4	CID000009395
Drug	BP-4,5-oxide	CYP2A6 CYP2A7 CYP2A13	9.43e-05	61	33	3	CID000037786
Drug	chlorzoxazone	CYP2A6 CYP2A7 CYP2A13	1.04e-04	63	33	3	CID000002733
Drug	D-702	CYP2A6 CYP2A13	1.11e-04	11	33	2	CID000054077
Drug	nonyl-beta-D-glucopyranoside	TACR1 RHO	1.11e-04	11	33	2	CID000113558
Drug	propoxyphene	CYP2A6 CYP2A7 CYP2A13	1.25e-04	67	33	3	CID000010100
Drug	piperonyl butoxide	CYP2A6 CYP2A7 CYP2A13	1.25e-04	67	33	3	CID000005794
Drug	5,6-epoxyeicosatrienoic acid	CYP2A6 CYP2A7 CYP2A13	1.30e-04	68	33	3	CID000001778
Drug	Sv 5	OCA2 SLC12A1	1.33e-04	12	33	2	CID000088360
Drug	1h1q	CYP2A6 CYP2A7 CYP2A13	1.42e-04	70	33	3	CID000001540
Drug	4-bromophenol	CYP2A6 CYP2A7 CYP2A13	1.42e-04	70	33	3	CID000007808
Drug	1-aminobenzotriazole	CYP2A6 CYP2A13 SLC12A2	1.48e-04	71	33	3	CID000001367
Drug	1,2-dibromoethane	CYP2A6 CYP2A7 CYP2A13	1.48e-04	71	33	3	CID000007839
Drug	pseudococaine	SLC6A5 CFH CYP2A6 LIPA TACR1 CMKLR1	1.49e-04	570	33	6	CID000002826
Drug	carteolol	CYP2A6 CYP2A7 CYP2A13	1.55e-04	72	33	3	CID000002583
Drug	Skatole	CYP2A6 CYP2A13	1.57e-04	13	33	2	ctd:D012862
Drug	d 6-20	CYP2A6 CYP2A13	1.57e-04	13	33	2	CID000161569
Drug	2,2,2-trichloroethanol	CYP2A6 CYP2A7 CYP2A13	1.61e-04	73	33	3	CID000008259
Drug	chloral	CYP2A6 CYP2A7 CYP2A13	1.61e-04	73	33	3	CID000006407
Drug	hydride	CYP2A6 CYP2A7 CYP2A13 SLC12A1 SLC4A4 ATP6V0A4 RHO	1.61e-04	835	33	7	CID000000783
Drug	dicyclohexyl phthalate	GPR83 CYP2A6 CYP2A13 CMKLR1 SLC12A2 SLC4A4 GALR2	1.63e-04	836	33	7	ctd:C036042
Drug	7-hydroxycoumarin	CYP2A6 CYP2A7 CYP2A13	1.74e-04	75	33	3	CID005281426
Drug	debrisoquine	CYP2A6 CYP2A7 CYP2A13	1.74e-04	75	33	3	CID000002965
Drug	Rapamycin; Up 200; 0.1uM; HL60; HT_HG-U133A	TACR1 GALR2 DAGLA RHO	1.76e-04	195	33	4	2702_UP
Drug	Felbinac [5728-52-9]; Down 200; 18.8uM; MCF7; HT_HG-U133A	PIGL ERG28 SLC4A4 ATP10D	1.79e-04	196	33	4	5700_DN
Drug	MnPN	CYP2A6 CYP2A13	1.83e-04	14	33	2	CID000062163
Drug	Alprostadil [745-65-3]; Up 200; 11.2uM; MCF7; HT_HG-U133A	OCA2 TACR1 ERG28 SLC4A4	1.86e-04	198	33	4	4179_UP
Drug	rofecoxib; Up 200; 10uM; MCF7; HG-U133A	SLC6A5 OCA2 NUP188 RHO	1.86e-04	198	33	4	256_UP
Drug	C20H32O4	CYP2A6 CYP2A7 CYP2A13	1.96e-04	78	33	3	CID000001440
Disease	Niemann-Pick Disease, Type C1	NPC1 LIPA	1.14e-06	2	32	2	C3179455
Disease	Niemann-Pick Disease, Type D	NPC1 LIPA	1.14e-06	2	32	2	C0268247
Disease	Niemann-Pick Disease, Type C	NPC1 LIPA	1.14e-06	2	32	2	C0220756
Disease	renal tubular acidosis (is_implicated_in)	SLC4A4 ATP6V0A4	6.83e-06	4	32	2	DOID:14219 (is_implicated_in)
Disease	Distal Renal Tubular Acidosis	SLC4A4 ATP6V0A4	1.14e-05	5	32	2	C1704380
Disease	renal tubular acidosis (implicated_via_orthology)	SLC4A4 ATP6V0A4	3.18e-05	8	32	2	DOID:14219 (implicated_via_orthology)
Disease	C-reactive protein measurement	NPC1 UBR2 CYP2A6 CYP2A7 PIGL LIPA CDH4 DAGLA	3.33e-05	1206	32	8	EFO_0004458
Disease	nicotine metabolite ratio	CYP2A6 CYP2A7	7.47e-05	12	32	2	EFO_0007794
Disease	neutrophil count, eosinophil count	NPC1 UBR2 PIGL LIPA	8.10e-05	213	32	4	EFO_0004833, EFO_0004842
Disease	caffeine metabolite measurement	CYP2A6 CYP2A7	1.93e-04	19	32	2	EFO_0007872
Disease	cotinine measurement	CYP2A6 CDH4	2.84e-04	23	32	2	EFO_0007813
Disease	Brain Diseases	SLC6A5 CYP2A6	3.37e-04	25	32	2	C0006111
Disease	Encephalopathies	SLC6A5 CYP2A6	3.93e-04	27	32	2	C0085584
Disease	serum albumin measurement	CFH CYP2A6 CYP2A7 SLC12A2 DAGLA	4.11e-04	592	32	5	EFO_0004535
Disease	bitter non-alcoholic beverage consumption measurement	CYP2A6 TMEM161B	5.54e-04	32	32	2	EFO_0010093
Disease	sleep apnea measurement, obstructive sleep apnea	GPR83 CDH4	5.89e-04	33	32	2	EFO_0003918, EFO_0007817
Disease	lymphocyte percentage of leukocytes	UBR2 PIGL LIPA CALR3 SLC12A1	6.97e-04	665	32	5	EFO_0007993
Disease	multiple system atrophy	PKHD1L1 CDH4	8.66e-04	40	32	2	EFO_1001050
Disease	complement factor H measurement	CFH CYP2A6	9.10e-04	41	32	2	EFO_0008097
Disease	bitter beverage consumption measurement	CYP2A6 TMEM161B	9.55e-04	42	32	2	EFO_0010089

Protein segments in the cluster

Peptide	Gene	Start	Entry
MARALVQLWAICMLR	CALR3	1	Q96L12
LLVCLTVMVLMSVWQ	CYP2A6	11	P11509
MLDELAVLWVLMCAL	ACER2	91	Q5QJU3
MRLLAKIICLMLWAI	CFH	1	P08603
DVLWCVMLLVIMCLT	ATP10D	321	Q9P241
RVWAMIIMLCLIAAV	OCA2	421	Q04671
TLCMILFLMIEVWRQ	ITPRIP	91	Q8IWB1
TRMVIIMVIAFLICW	RHO	251	P08100
VTLRVLRMMRIFWVI	KCNG3	286	Q8TAE7
NVLRSWLVMVSIIAM	ERG28	6	Q9UKR5
IKMLMLVVVLFALCW	GPR83	291	Q9NYM4
LWSAVIMCATIAMVL	NPC1	1121	O15118
RMILIVAALFCLCWM	GALR2	236	O43603
SELVMKCLWRMVRLL	CKAP5	1706	Q14008
LLACLTVMVLMSVWR	CYP2A13	11	Q16696
LLACLTVMVLMSVWQ	CYP2A7	11	P20853
CILILLTMVLLFVMW	CDH4	741	P55283
LLSCMIAEMAIIWLS	DAGLA	66	Q9Y4D2
MVSWMICRLVVLVFG	REEP4	1	Q9H6H4
LWLIILLCALRLAMM	TMEM161B	316	Q8NDZ6
MLACSVIWIPIMFVI	SLC6A5	721	Q9Y345
MEAMWLLCVALAVLA	PIGL	1	Q9Y2B2
VVVMWIILAHKRMRT	TACR1	51	P25103
RCMLNIWGVMLFIRL	SLC12A1	186	Q13621
RSVRLAYMACMVIWV	CMKLR1	151	Q99788
MNMRVCIQLVFALWL	OR4E2	136	Q8NGC2
VLVRCMLNIWGVMLF	SLC12A2	291	P55011
QMLVSAWRMLLIIAT	NUP188	1101	Q5SRE5
IMTVVISCLVGRMWL	PKHD1L1	4211	Q86WI1
TVMLLAALWMILNER	ATP6V0A4	416	Q9HBG4
VAILMVICSLMALPW	SLC4A4	826	Q9Y6R1
VMLCIMGTILQWAVE	UBR2	896	Q8IWV8
MKMRFLGLVVCLVLW	LIPA	1	P38571