Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	actin filament bundle	VIL1 SYNPO PRKCZ DIAPH3	6.81e-05	118	39	4	GO:0032432
GeneOntologyCellularComponent	actin cytoskeleton	VIL1 SYNPO PRKCZ DIAPH3 MYO15A STOML2 NOS1AP	8.31e-05	576	39	7	GO:0015629
GeneOntologyCellularComponent	outer dynein arm	DNAH5 DNAH8	2.21e-04	12	39	2	GO:0036157
GeneOntologyCellularComponent	cytoplasmic region	GRIK3 PRKCZ RIMS1 DNAH5 DNAH8	5.24e-04	360	39	5	GO:0099568
GeneOntologyCellularComponent	cluster of actin-based cell projections	VIL1 DIAPH3 PLEC MYO15A	7.74e-04	223	39	4	GO:0098862
GeneOntologyCellularComponent	axonemal dynein complex	DNAH5 DNAH8	9.90e-04	25	39	2	GO:0005858
GeneOntologyCellularComponent	sarcoplasm	STIM1 PLEC NOS1AP	1.25e-03	114	39	3	GO:0016528
GeneOntologyCellularComponent	sodium channel complex	GRIK3 UNC80	1.33e-03	29	39	2	GO:0034706
GeneOntologyCellularComponent	plasma membrane raft	STIM1 JAK2 NOS1AP	2.59e-03	147	39	3	GO:0044853
GeneOntologyCellularComponent	Z disc	SYNPO PLEC NOS1AP	2.79e-03	151	39	3	GO:0030018
GeneOntologyCellularComponent	sarcoplasmic reticulum membrane	STIM1 NOS1AP	3.19e-03	45	39	2	GO:0033017
GeneOntologyCellularComponent	cell cortex region	PRKCZ RIMS1	3.19e-03	45	39	2	GO:0099738
GeneOntologyCellularComponent	I band	SYNPO PLEC NOS1AP	3.64e-03	166	39	3	GO:0031674
GeneOntologyCellularComponent	glutamatergic synapse	JAK2 SYNPO GRIK3 PRKCZ RIMS1 NOS1AP	3.79e-03	817	39	6	GO:0098978
GeneOntologyCellularComponent	membrane raft	STIM1 JAK2 STOML2 NOS1AP	4.51e-03	362	39	4	GO:0045121
GeneOntologyCellularComponent	dynein complex	DNAH5 DNAH8	4.57e-03	54	39	2	GO:0030286
GeneOntologyCellularComponent	membrane microdomain	STIM1 JAK2 STOML2 NOS1AP	4.60e-03	364	39	4	GO:0098857
GeneOntologyCellularComponent	transcription elongation factor complex	AFF1 ICE2	4.90e-03	56	39	2	GO:0008023
GeneOntologyCellularComponent	supramolecular fiber	STIM1 SYNPO DIAPH3 PLEC DNAH5 DNAH8 NOS1AP	5.61e-03	1179	39	7	GO:0099512
GeneOntologyCellularComponent	axon	STIM1 SYNPO GRIK3 PRKCZ PLEC UNC80	5.77e-03	891	39	6	GO:0030424
GeneOntologyCellularComponent	supramolecular polymer	STIM1 SYNPO DIAPH3 PLEC DNAH5 DNAH8 NOS1AP	5.82e-03	1187	39	7	GO:0099081
Domain	GOLGA6L	GOLGA6L6 GOLGA6L2	6.67e-05	6	40	2	IPR026737
Domain	Dynein_heavy_dom-1	DNAH5 DNAH8	1.24e-04	8	40	2	IPR013594
Domain	DHC_N1	DNAH5 DNAH8	1.24e-04	8	40	2	PF08385
Domain	DUF3699	GARIN5B TASOR2	1.59e-04	9	40	2	PF12480
Domain	DUF3699	GARIN5B TASOR2	1.59e-04	9	40	2	IPR022168
Domain	ATPase_dyneun-rel_AAA	DNAH5 DNAH8	4.00e-04	14	40	2	IPR011704
Domain	Dynein_heavy_chain_D4_dom	DNAH5 DNAH8	4.00e-04	14	40	2	IPR024317
Domain	Dynein_HC_stalk	DNAH5 DNAH8	4.00e-04	14	40	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH5 DNAH8	4.00e-04	14	40	2	IPR013602
Domain	DHC_N2	DNAH5 DNAH8	4.00e-04	14	40	2	PF08393
Domain	MT	DNAH5 DNAH8	4.00e-04	14	40	2	PF12777
Domain	AAA_8	DNAH5 DNAH8	4.00e-04	14	40	2	PF12780
Domain	AAA_5	DNAH5 DNAH8	4.00e-04	14	40	2	PF07728
Domain	DHC_fam	DNAH5 DNAH8	4.61e-04	15	40	2	IPR026983
Domain	Dynein_heavy_dom	DNAH5 DNAH8	4.61e-04	15	40	2	IPR004273
Domain	Dynein_heavy	DNAH5 DNAH8	4.61e-04	15	40	2	PF03028
Domain	FERM_central	JAK2 MYO15A	4.94e-03	49	40	2	IPR019748
Domain	FERM_domain	JAK2 MYO15A	4.94e-03	49	40	2	IPR000299
Domain	FERM_1	JAK2 MYO15A	5.13e-03	50	40	2	PS00660
Domain	FERM_2	JAK2 MYO15A	5.13e-03	50	40	2	PS00661
Domain	Band_41_domain	JAK2 MYO15A	5.13e-03	50	40	2	IPR019749
Domain	B41	JAK2 MYO15A	5.13e-03	50	40	2	SM00295
Domain	FERM_3	JAK2 MYO15A	5.13e-03	50	40	2	PS50057
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	STIM1 SECISBP2 DIAPH3 PLEC RBM33 ICE2 LYPLA2 NOS1AP	2.14e-06	724	42	8	36232890
Pubmed	Serine/Threonine kinase 16 phosphorylates STAT3 and confers a JAK2-Inhibition resistance phenotype in triple-negative breast cancer.	STK16 JAK2	4.27e-06	3	42	2	38723720
Pubmed	Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia.	JAK2 ERG	8.53e-06	4	42	2	23533276
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH5 DNAH8	2.98e-05	7	42	2	9256245
Pubmed	Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.	DNAH5 DNAH8	2.98e-05	7	42	2	31178125
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	VIL1 GARIN5B SYNPO RIMS1 DIAPH3 PLEC ACACB DNAH8 TASOR2	4.56e-05	1442	42	9	35575683
Pubmed	Developmental Renal Glomerular Defects at the Origin of Glomerulocystic Disease.	SYNPO PRKCZ	5.10e-05	9	42	2	33113370
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	STIM1 SYNPO RIMS1 PLEC ACACB GATAD2B STOML2 NOS1AP	5.66e-05	1139	42	8	36417873
Pubmed	[Detection of fusion genes resulting from chromosome abnormalities in childhood acute lymphoblastic leukemia].	AFF1 ERG	6.37e-05	10	42	2	16215946
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	DTX2 ACACB RFX7 RBM33	6.66e-05	180	42	4	35198878
Pubmed	The little elongation complex regulates small nuclear RNA transcription.	AFF1 ICE2	9.32e-05	12	42	2	22195968
Pubmed	Wnt5a is essential for intestinal elongation in mice.	VIL1 PRKCZ	1.10e-04	13	42	2	19100728
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH5 DNAH8	1.28e-04	14	42	2	9373155
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	MTMR1 SLC45A2 ACACB DNAH8 UNC80	1.48e-04	420	42	5	28065597
Pubmed	RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells.	PRKCZ MYO15A	1.48e-04	15	42	2	36260679
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	VIL1 GARIN5B MBOAT1 TSGA10IP	1.80e-04	233	42	4	37704626
Pubmed	Hemidesmosome integrity protects the colon against colitis and colorectal cancer.	VIL1 PLEC	2.15e-04	18	42	2	27371534
Pubmed	CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity.	VIL1 PRKCZ	2.67e-04	20	42	2	19726564
Pubmed	The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.	AFF1 RFX7 NOS1AP	2.90e-04	106	42	3	31024071
Pubmed	A human MAP kinase interactome.	SYNPO PRKCZ PLEC RBM33 MAP3K4	2.90e-04	486	42	5	20936779
Pubmed	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	KLHL29 RIMS1 AJAP1 CREB5	2.94e-04	265	42	4	19240061
Pubmed	AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development.	PRKCZ ACACB	2.95e-04	21	42	2	19217427
Pubmed	Characterization of the zinc-induced Shank3 interactome of mouse synaptosome.	MYO15A STOML2 TASOR2	3.14e-04	109	42	3	29111324
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	AFF1 RIMS1 PLEC ERG RFX7 GATAD2B	3.16e-04	774	42	6	15302935
Pubmed	Gene expression in the developing mouse retina by EST sequencing and microarray analysis.	AFF1 AJAP1 RFX7	6.81e-04	142	42	3	11812828
Pubmed	Primary Ciliary Dyskinesia	DNAH5 DNAH8	6.90e-04	32	42	2	20301301
Pubmed	Functional proteomics mapping of a human signaling pathway.	SECISBP2 AFF1 DIAPH3 PLEC GATAD2B	7.05e-04	591	42	5	15231748
Pubmed	Cdx2 regulates endo-lysosomal function and epithelial cell polarity.	VIL1 PRKCZ	7.34e-04	33	42	2	20551175
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	STIM1 JAK2 AFF1 PLEC GATAD2B MAP3K4	7.41e-04	910	42	6	36736316
Pubmed	Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.	TSGA10IP CREB5 GATAD2B	7.83e-04	149	42	3	25184681
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	DTX2 RFX7 RBM33	8.29e-04	152	42	3	38360978
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	STK16 VIL1 SECISBP2 SYNPO DTX2 PLEC RBM33	8.33e-04	1293	42	7	15342556
Pubmed	Novel loci regulating bone anabolic response to loading: expression QTL analysis in C57BL/6JXC3H/HeJ mice cross.	JAK2 MAP3K4	9.74e-04	38	42	2	17543594
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	MTMR1 STOML2 NOS1AP	1.09e-03	167	42	3	25659891
Interaction	GOLGA6L6 interactions	GOLGA6L6 GOLGA6L2	1.27e-05	3	42	2	int:GOLGA6L6
Cytoband	2q35	STK16 VIL1 UNC80	5.36e-05	79	42	3	2q35
GeneFamily	Dyneins, axonemal	DNAH5 DNAH8	1.90e-04	17	22	2	536
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	JAK2 MYO15A	1.67e-03	50	22	2	1293
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DIAPH3 AJAP1 DNAH5 CREB5 NOS1AP	9.80e-07	191	42	5	9032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DIAPH3 AJAP1 DNAH5 CREB5 NOS1AP	9.80e-07	191	42	5	5717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-Proliferative_Immature_MyoFibroblast\|E16.5-samps / Age Group, Lineage, Cell class and subclass	JAK2 PRKCZ RIMS1 CREB5	7.94e-06	135	42	4	ed0f94d3839eea3b60217c4352159ed481361f13
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLC45A2 GRIK3 RIMS1 UNC80	1.84e-05	167	42	4	c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KLHL29 VIL1 DIAPH3 CREB5	2.41e-05	179	42	4	58ae5a97fe2a14e1c6fdeb886397eb06fdaf0428
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIK3 MYO15A DNAH5 UNC80	2.68e-05	184	42	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIK3 MYO15A DNAH5 UNC80	2.68e-05	184	42	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIK3 MYO15A DNAH5 UNC80	2.68e-05	184	42	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KLHL29 VIL1 SYNPO PRKCZ	3.04e-05	190	42	4	3cf464664d6aa22b212e60b70885953887e92483
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DTX2 RIMS1 DNAH5 NOS1AP	3.57e-05	198	42	4	af399569c718f5fd971d73a7926768c9311002a3
Disease	retinal vasculature measurement	KLHL29 SLC45A2 ERG AJAP1 MBOAT1 DNAH5 CREB5 NOS1AP	3.95e-07	517	40	8	EFO_0010554
Disease	basophil count	STIM1 KLHL29 JAK2 AFF1 ERG TSGA10IP CREB5	3.52e-06	483	40	7	EFO_0005090
Disease	granulocyte percentage of myeloid white cells	KLHL29 GLMN ERG CREB5 NOS1AP	3.02e-05	268	40	5	EFO_0007997
Disease	leukemia	JAK2 PRKCZ ERG	5.77e-05	55	40	3	C0023418
Disease	Paranoia	DNAH8 ICE2	9.78e-05	11	40	2	C1456784
Disease	platelet-to-lymphocyte ratio	JAK2 VIL1 AFF1 PLEC ERG	1.27e-04	363	40	5	EFO_0008446
Disease	response to methotrexate, neurotoxicity	STIM1 MBOAT1	3.02e-04	19	40	2	EFO_0011057, GO_0031427
Disease	creatinine measurement	VIL1 GLMN PRKCZ PLEC MBOAT1 ICE2 UNC80	3.42e-04	995	40	7	EFO_0004518
Disease	atopic eczema	AFF1 ERG CREB5 GATAD2B	3.73e-04	252	40	4	EFO_0000274
Disease	mean platelet volume	STIM1 KLHL29 JAK2 MTMR1 AFF1 PLEC NOS1AP	3.97e-04	1020	40	7	EFO_0004584
Disease	Ovarian Serous Adenocarcinoma	JAK2 MAP3K4	4.45e-04	23	40	2	C1335177
Disease	smoking cessation	KLHL29 PRKCZ RBM33 NOS1AP	9.66e-04	325	40	4	EFO_0004319
Disease	red blood cell density measurement	VIL1 AFF1 PLEC ERG MYO15A RFX7	1.12e-03	880	40	6	EFO_0007978
Disease	multiple sclerosis	JAK2 AFF1 PLEC ERG TSGA10IP	1.20e-03	594	40	5	MONDO_0005301
Disease	valine measurement	AFF1 ACACB	1.35e-03	40	40	2	EFO_0009792
Disease	guilt measurement	KLHL29 GRIK3	1.35e-03	40	40	2	EFO_0009595

Protein segments in the cluster

Peptide	Gene	Start	Entry
PEMPHSPAQTERMQK	C1orf140	61	Q5VVS0
KHMPPPNMTTNERRV	ERG	111	P11308
PRPPRVERIHGQMQM	AJAP1	81	Q9UKB5
RTPMPKDVRQSLSPM	DIAPH3	1081	Q9NSV4
PRMRPQMPIHQNLKE	MTMR1	606	Q13613
SKRPMQQMQPTAPRN	RBM33	691	Q96EV2
TQPPPAQSHRMDLMI	INTS9	476	Q9NV88
PTSPTLQRPTHMNQM	JAK2	521	O60674
MLPSSHPNRMTVPIS	ACACB	1326	O00763
HLHNRQRQPMPASMP	CREB5	166	Q02930
ASPQVQPMHSEAKMR	CREB5	221	Q02930
MSTRPQPQEHMPKVL	MYO15A	2331	Q9UKN7
VPMQMPKPSRVQQAL	DTX2	321	Q86UW9
PHREMRMNPKAITAP	DNAH8	2151	Q96JB1
HLPPHPMMSEKTRQN	GOLGA6L2	6	Q8N9W4
PHLPTHPMMSKETRQ	GOLGA6L6	31	A8MZA4
LPHMLMSQRVIAPNP	GATAD2B	256	Q8WXI9
VKPPPEEQQMRMHAR	RIMS1	366	Q86UR5
MPTRSHRNPVSMETK	ICE2	946	Q659A1
LPMKPQAHTQRRPQT	MBOAT1	471	Q6ZNC8
CPHAPRIPVTLNMKM	LYPLA2	56	O95372
SHPQEPMLTASPRML	NOS1AP	256	O75052
TCQRRVKHKPQPPMM	GRIK3	871	Q13003
EPPKRPTSRLIMHSM	SLC45A2	26	Q9UMX9
HREMRMNPKAITAPQ	DNAH5	2286	Q8TE73
PPQLSSRMKHIRQAM	LGSN	66	Q5TDP6
PSTPRQMKRMSTKHQ	MAP3K4	86	Q9Y6R4
IPNMPPEMQLKVLHS	GLMN	546	Q92990
MGVRMEHSPQRPPRT	TSGA10IP	521	Q3SY00
SMMTVDPHQRPHIPL	STK16	271	O75716
PRPQRHIMSRSPMVE	SYNPO	526	Q8N3V7
RRMSQMKTPHNPLDS	SECISBP2	496	Q96T21
HMSDRQRVAPKPPQM	STIM1	526	Q13586
HNPKMAQPRTEPMPS	AFF1	131	P51825
RKPTHVNMNRDIKMP	C12orf40	71	Q86WS4
QIRVPMGKEPPHLMS	VIL1	476	P09327
MRKLCNQVPIPEMPH	UNC80	596	Q8N2C7
SSPVKPMQRPMATHP	RFX7	946	Q2KHR2
HVPPRVKESMQMQVE	STOML2	181	Q9UJZ1
MVMPARRTPHVQAVQ	PLEC	106	Q15149
KPSTMQRHEMVANPS	ZNF66	61	Q6ZN08
RVQPKRKASMPHMVQ	TASOR2	346	Q5VWN6
KRVSQEPMRMPAQHP	GARIN5B	851	Q8N5Q1
MLPHARQEMQTPRTR	KLHL29	561	Q96CT2
RKHMDSVMPSQEPPV	PRKCZ	181	Q05513