Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	extracellular matrix structural constituent	FBN1 VWF TNC SSPOP MUC5AC FBN3	7.24e-06	188	50	6	GO:0005201
GeneOntologyMolecularFunction	calcium ion binding	NELL1 THBD FBN1 PLCB2 RET ITGB1 MEX3B FBN3 NOTCH3 NOTCH4	1.37e-05	749	50	10	GO:0005509
GeneOntologyCellularComponent	extracellular matrix	FBN1 FCGBP VWF TNC ADAMTSL3 ITGB1 SSPOP MUC5AC FBN3 OTOG	1.93e-06	656	48	10	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	FBN1 FCGBP VWF TNC ADAMTSL3 ITGB1 SSPOP MUC5AC FBN3 OTOG	1.98e-06	658	48	10	GO:0030312
GeneOntologyCellularComponent	microfibril	FBN1 FBN3	3.96e-04	13	48	2	GO:0001527
Domain	VWC_out	NELL1 FCGBP VWF CRIM1 KCP SSPOP MUC5AC OTOG	1.08e-16	19	50	8	SM00215
Domain	VWF_dom	NELL1 FCGBP VWF CRIM1 KCP SSPOP MUC5AC OTOG	1.61e-13	42	50	8	IPR001007
Domain	Unchr_dom_Cys-rich	FCGBP VWF KCP SSPOP MUC5AC OTOG	4.56e-13	13	50	6	IPR014853
Domain	C8	FCGBP VWF KCP SSPOP MUC5AC OTOG	4.56e-13	13	50	6	SM00832
Domain	TIL_dom	FCGBP VWF KCP SSPOP MUC5AC OTOG	7.97e-13	14	50	6	IPR002919
Domain	VWD	FCGBP VWF KCP SSPOP MUC5AC OTOG	2.12e-12	16	50	6	SM00216
Domain	VWF_type-D	FCGBP VWF KCP SSPOP MUC5AC OTOG	2.12e-12	16	50	6	IPR001846
Domain	VWFD	FCGBP VWF KCP SSPOP MUC5AC OTOG	2.12e-12	16	50	6	PS51233
Domain	VWD	FCGBP VWF KCP SSPOP MUC5AC OTOG	2.12e-12	16	50	6	PF00094
Domain	VWC	NELL1 FCGBP VWF CRIM1 KCP SSPOP MUC5AC	7.54e-12	38	50	7	SM00214
Domain	TIL	FCGBP VWF SSPOP MUC5AC OTOG	8.74e-11	12	50	5	PF01826
Domain	C8	FCGBP VWF SSPOP MUC5AC OTOG	8.74e-11	12	50	5	PF08742
Domain	VWFC_1	NELL1 VWF CRIM1 KCP SSPOP MUC5AC	4.95e-10	36	50	6	PS01208
Domain	VWFC_2	NELL1 VWF CRIM1 KCP SSPOP MUC5AC	6.98e-10	38	50	6	PS50184
Domain	Growth_fac_rcpt_	NELL1 THBD FBN1 CRIM1 TNC FBN3 NOTCH3 NOTCH4	7.89e-09	156	50	8	IPR009030
Domain	VWC	NELL1 VWF CRIM1 KCP MUC5AC	1.05e-08	28	50	5	PF00093
Domain	EGF_3	NELL1 THBD FBN1 TNC SSPOP FBN3 NOTCH3 NOTCH4 OTOG	1.08e-08	235	50	9	PS50026
Domain	EGF-like_dom	NELL1 THBD FBN1 FCGBP TNC FBN3 NOTCH3 NOTCH4 OTOG	1.79e-08	249	50	9	IPR000742
Domain	EGF_1	NELL1 THBD FBN1 TNC ITGB1 SSPOP FBN3 NOTCH3 NOTCH4	2.20e-08	255	50	9	PS00022
Domain	EGF_CA	NELL1 THBD FBN1 FBN3 NOTCH3 NOTCH4	1.08e-07	86	50	6	PF07645
Domain	EGF	NELL1 THBD FBN1 FCGBP TNC FBN3 NOTCH3 NOTCH4	1.90e-07	235	50	8	SM00181
Domain	EGF_Ca-bd_CS	NELL1 THBD FBN1 FBN3 NOTCH3 NOTCH4	2.22e-07	97	50	6	IPR018097
Domain	EGF_CA	NELL1 THBD FBN1 FBN3 NOTCH3 NOTCH4	2.50e-07	99	50	6	PS01187
Domain	ASX_HYDROXYL	NELL1 THBD FBN1 FBN3 NOTCH3 NOTCH4	2.66e-07	100	50	6	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	NELL1 THBD FBN1 FBN3 NOTCH3 NOTCH4	3.76e-07	106	50	6	IPR000152
Domain	EGF-like_CS	NELL1 THBD FBN1 TNC ITGB1 FBN3 NOTCH3 NOTCH4	4.22e-07	261	50	8	IPR013032
Domain	EGF_2	NELL1 THBD FBN1 TNC SSPOP FBN3 NOTCH3 NOTCH4	4.74e-07	265	50	8	PS01186
Domain	Cys_knot_C	VWF SSPOP MUC5AC OTOG	5.51e-07	25	50	4	IPR006207
Domain	CTCK_2	VWF SSPOP MUC5AC OTOG	5.51e-07	25	50	4	PS01225
Domain	EGF_CA	NELL1 THBD FBN1 FBN3 NOTCH3 NOTCH4	8.62e-07	122	50	6	SM00179
Domain	EGF-like_Ca-bd_dom	NELL1 THBD FBN1 FBN3 NOTCH3 NOTCH4	9.49e-07	124	50	6	IPR001881
Domain	ZF_RING_1	RNF224 TRAF3 MEX3A TRIM28 RNF44 TRIM13 MEX3B RNF182	9.60e-07	291	50	8	PS00518
Domain	ZF_RING_2	RNF224 TRAF3 MEX3A TRIM28 RNF44 TRIM13 MEX3B RNF182	1.15e-06	298	50	8	PS50089
Domain	RING	RNF224 TRAF3 MEX3A TRIM28 RNF44 TRIM13 MEX3B RNF182	1.37e-06	305	50	8	SM00184
Domain	Znf_RING	RNF224 TRAF3 MEX3A TRIM28 RNF44 TRIM13 MEX3B RNF182	2.24e-06	326	50	8	IPR001841
Domain	-	PHF1 RNF224 TRAF3 MEX3A TRIM28 RNF44 TRIM13 MEX3B RNF182	2.59e-06	449	50	9	3.30.40.10
Domain	Znf_RING/FYVE/PHD	PHF1 RNF224 TRAF3 MEX3A TRIM28 RNF44 TRIM13 MEX3B RNF182	3.10e-06	459	50	9	IPR013083
Domain	CTCK_1	VWF SSPOP MUC5AC	1.43e-05	18	50	3	PS01185
Domain	EGF_extracell	NELL1 TNC ITGB1 NOTCH3	1.98e-05	60	50	4	IPR013111
Domain	EGF_2	NELL1 TNC ITGB1 NOTCH3	1.98e-05	60	50	4	PF07974
Domain	FBN	FBN1 FBN3	2.10e-05	3	50	2	IPR011398
Domain	EGF	THBD TNC FBN3 NOTCH3 NOTCH4	2.14e-05	126	50	5	PF00008
Domain	TSP_1	THSD7A THSD7B ADAMTSL3 SSPOP	2.41e-05	63	50	4	PF00090
Domain	CT	VWF MUC5AC OTOG	2.68e-05	22	50	3	SM00041
Domain	TSP1	THSD7A THSD7B ADAMTSL3 SSPOP	2.73e-05	65	50	4	SM00209
Domain	TSP1_rpt	THSD7A THSD7B ADAMTSL3 SSPOP	2.73e-05	65	50	4	IPR000884
Domain	TSP1	THSD7A THSD7B ADAMTSL3 SSPOP	2.73e-05	65	50	4	PS50092
Domain	Notch	NOTCH3 NOTCH4	4.20e-05	4	50	2	IPR008297
Domain	NODP	NOTCH3 NOTCH4	4.20e-05	4	50	2	PF07684
Domain	Notch_NODP_dom	NOTCH3 NOTCH4	4.20e-05	4	50	2	IPR011656
Domain	Notch_NOD_dom	NOTCH3 NOTCH4	4.20e-05	4	50	2	IPR010660
Domain	NOD	NOTCH3 NOTCH4	4.20e-05	4	50	2	PF06816
Domain	NOD	NOTCH3 NOTCH4	4.20e-05	4	50	2	SM01338
Domain	NODP	NOTCH3 NOTCH4	4.20e-05	4	50	2	SM01339
Domain	cEGF	THBD FBN1 FBN3	4.49e-05	26	50	3	IPR026823
Domain	cEGF	THBD FBN1 FBN3	4.49e-05	26	50	3	PF12662
Domain	hEGF	FBN3 NOTCH3 NOTCH4	5.64e-05	28	50	3	PF12661
Domain	LNR	NOTCH3 NOTCH4	6.99e-05	5	50	2	PS50258
Domain	TB	FBN1 FBN3	1.46e-04	7	50	2	PF00683
Domain	Notch_dom	NOTCH3 NOTCH4	1.46e-04	7	50	2	IPR000800
Domain	Notch	NOTCH3 NOTCH4	1.46e-04	7	50	2	PF00066
Domain	Hirudin/antistatin	CRIM1 MUC5AC	1.46e-04	7	50	2	IPR011061
Domain	NL	NOTCH3 NOTCH4	1.46e-04	7	50	2	SM00004
Domain	-	FBN1 FBN3	1.95e-04	8	50	2	3.90.290.10
Domain	TB	FBN1 FBN3	2.50e-04	9	50	2	PS51364
Domain	TB_dom	FBN1 FBN3	2.50e-04	9	50	2	IPR017878
Domain	Znf_RING_CS	RNF224 TRAF3 TRIM13 RNF182	9.42e-04	163	50	4	IPR017907
Domain	TNFR_c6	NGFR FAS	1.57e-03	22	50	2	PF00020
Domain	TNFR	NGFR FAS	2.19e-03	26	50	2	SM00208
Domain	DEATH	NGFR FAS	2.36e-03	27	50	2	SM00005
Domain	VWF_A	VWF TSPAN10 ITGB1	2.36e-03	99	50	3	IPR002035
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	THSD7A THSD7B ADAMTSL3 SSPOP MUC5AC NOTCH3 NOTCH4	1.04e-09	68	42	7	M27303
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	THSD7A THSD7B ADAMTSL3 SSPOP MUC5AC NOTCH3 NOTCH4	1.91e-07	143	42	7	M27275
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	THSD7A THSD7B ADAMTSL3 SSPOP	5.19e-06	39	42	4	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	THSD7A THSD7B ADAMTSL3 SSPOP	5.19e-06	39	42	4	MM15165
Pathway	REACTOME_DISEASES_OF_METABOLISM	THSD7A THSD7B ADAMTSL3 SSPOP MUC5AC NOTCH3 NOTCH4	8.06e-06	250	42	7	M27554
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	THSD7A THSD7B ADAMTSL3 SSPOP MUC5AC	1.71e-05	109	42	5	MM15164
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	THSD7A THSD7B ADAMTSL3 SSPOP MUC5AC	1.86e-05	111	42	5	M27416
Pathway	REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	FBN1 VWF TNC ITGB1	7.47e-05	76	42	4	MM14867
Pathway	REACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3	NOTCH3 NOTCH4	8.62e-05	5	42	2	M27411
Pathway	REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI	NOTCH3 NOTCH4	8.62e-05	5	42	2	MM14733
Pathway	WP_CANCER_PATHWAYS	TRAF3 PLCB2 RET NCOA4 FAS ITGB1 NOTCH3 NOTCH4	1.06e-04	507	42	8	M48302
Pathway	REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	FBN1 VWF TNC ITGB1	1.16e-04	85	42	4	M16441
Pathway	REACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM	NOTCH3 NOTCH4	1.29e-04	6	42	2	M27068
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	FBN1 ITGB1 FBN3	1.78e-04	37	42	3	M27134
Pathway	REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING	NOTCH3 NOTCH4	1.80e-04	7	42	2	MM14734
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	FBN1 ITGB1 FBN3	2.99e-04	44	42	3	M26969
Pathway	KEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION	NOTCH3 NOTCH4	4.69e-04	11	42	2	M47865
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_DEATH_RECEPTORS_AND_LIGANDS	PPP1R13B FAS	5.61e-04	12	42	2	M27631
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380	NOTCH3 NOTCH4	5.61e-04	12	42	2	M47532
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381	NOTCH3 NOTCH4	5.61e-04	12	42	2	M47533
Pathway	WP_CELL_LINEAGE_MAP_FOR_NEURONAL_DIFFERENTIATION	TNC NGFR ITGB1 SLC17A6	6.24e-04	132	42	4	M48110
Pathway	KEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY	NOTCH3 NOTCH4	6.62e-04	13	42	2	M47423
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382	NOTCH3 NOTCH4	6.62e-04	13	42	2	M47534
Pathway	PID_NOTCH_PATHWAY	SSPOP NOTCH3 NOTCH4	7.12e-04	59	42	3	M17
Pathway	WP_DEVELOPMENT_OF_URETERIC_COLLECTION_SYSTEM	CRIM1 RET ITGB1	7.48e-04	60	42	3	M40048
Pathway	PID_INTEGRIN1_PATHWAY	FBN1 TNC ITGB1	9.88e-04	66	42	3	M18
Pathway	REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN	VWF ITGB1	1.01e-03	16	42	2	M9450
Pathway	REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI	NOTCH3 NOTCH4	1.29e-03	18	42	2	M614
Pubmed	Balancing neural crest cell intrinsic processes with those of the microenvironment in Tcof1 haploinsufficient mice enables complete enteric nervous system formation.	NGFR RET ITGB1	5.57e-08	6	50	3	22228097
Pubmed	Notch controls the magnitude of T helper cell responses by promoting cellular longevity.	FAS NOTCH3 NOTCH4	5.57e-08	6	50	3	22615412
Pubmed	Beta1 integrins are required for the invasion of the caecum and proximal hindgut by enteric neural crest cells.	TNC NGFR ITGB1	1.56e-07	8	50	3	19633172
Pubmed	Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart.	VWF NOTCH3 NOTCH4	7.92e-07	13	50	3	20558824
Pubmed	Molecular Profiling of the Developing Lacrimal Gland Reveals Putative Role of Notch Signaling in Branching Morphogenesis.	NGFR NOTCH3 NOTCH4	1.01e-06	14	50	3	28192800
Pubmed	Subtypes of medulloblastoma have distinct developmental origins.	TNC TRIM28 GAS1 NGFR	1.41e-06	57	50	4	21150899
Pubmed	Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation.	TNC NGFR ITGB1	1.55e-06	16	50	3	21067603
Pubmed	Modulation of Fas-induced apoptosis by p75 neurotrophin receptor in a human neuroblastoma cell line.	NGFR FAS	2.03e-06	2	50	2	16215672
Pubmed	The epidermal Integrin beta-1 and p75NTR positive cells proliferating and migrating during wound healing produce various growth factors, while the expression of p75NTR is decreased in patients with chronic skin ulcers.	NGFR ITGB1	2.03e-06	2	50	2	23642664
Pubmed	Transcriptomic data showing differentially expressed genes between Notch3 and Notch4 deleted mice.	NOTCH3 NOTCH4	2.03e-06	2	50	2	33665264
Pubmed	Thrombomodulin and von Willebrand factor: relation to endothelial dysfunction and disease outcome in children with acute lymphoblastic leukemia.	THBD VWF	2.03e-06	2	50	2	21150180
Pubmed	Notch3 signaling is associated with MUC5AC expression and favorable prognosis in patients with small intestinal adenocarcinomas.	MUC5AC NOTCH3	2.03e-06	2	50	2	24810798
Pubmed	Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma.	NOTCH3 NOTCH4	2.03e-06	2	50	2	17696940
Pubmed	Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation.	ITGB1 NOTCH4	2.03e-06	2	50	2	11909975
Pubmed	Prognostic value of plasma levels of thrombomodulin and von Willebrand factor in Egyptian children with acute lymphoblastic leukemia.	THBD VWF	2.03e-06	2	50	2	24243921
Pubmed	Blocking Notch3 Signaling Abolishes MUC5AC Production in Airway Epithelial Cells from Individuals with Asthma.	MUC5AC NOTCH3	2.03e-06	2	50	2	31922915
Pubmed	A genetic determinant that specifically regulates the frequency of hematopoietic stem cells.	NOTCH3 NOTCH4	2.03e-06	2	50	2	11777956
Pubmed	Kynurenines and oxidative status are independently associated with thrombomodulin and von Willebrand factor levels in patients with end-stage renal disease.	THBD VWF	2.03e-06	2	50	2	19477487
Pubmed	Effect of p75NTR on the regulation of photoreceptor apoptosis in the rd mouse.	PDE6B NGFR	2.03e-06	2	50	2	16402023
Pubmed	NELL-1 promotes cell adhesion and differentiation via Integrinβ1.	NELL1 ITGB1	2.03e-06	2	50	2	22807400
Pubmed	Structural insights into the mechanism of calmodulin binding to death receptors.	NGFR FAS	2.03e-06	2	50	2	24914971
Pubmed	Intraductal carcinoma of the salivary gland with NCOA4-RET: expanding the morphologic spectrum and an algorithmic diagnostic approach.	RET NCOA4	2.03e-06	2	50	2	33991527
Pubmed	Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma.	RET NCOA4	2.03e-06	2	50	2	8290261
Pubmed	Enhanced Notch3 signaling contributes to pulmonary emphysema in a Murine Model of Marfan syndrome.	FBN1 NOTCH3	2.03e-06	2	50	2	32616814
Pubmed	Crim1 regulates integrin signaling in murine lens development.	CRIM1 ITGB1	2.03e-06	2	50	2	26681494
Pubmed	Peptide TNIIIA2 Derived from Tenascin-C Contributes to Malignant Progression in Colitis-Associated Colorectal Cancer via β1-Integrin Activation in Fibroblasts.	TNC ITGB1	2.03e-06	2	50	2	31195598
Pubmed	Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients.	FBN1 FBN3	2.03e-06	2	50	2	15221638
Pubmed	Novel Roles for Notch3 and Notch4 Receptors in Gene Expression and Susceptibility to Ozone-Induced Lung Inflammation in Mice.	NOTCH3 NOTCH4	2.03e-06	2	50	2	25658374
Pubmed	Prevalence of RET/PTC1 and RET/PTC3 gene rearrangements in Chennai population and its correlation with clinical parameters.	RET NCOA4	2.03e-06	2	50	2	24957039
Pubmed	[Clinical Significance of Thrombospondin Type 1 Domain-Containing 7A and Neural Epidermal Growth Factor-Like 1 Protein in M-Type Phospholipase A2 Receptor-Negative Membranous Nephropathy].	NELL1 THSD7A	2.03e-06	2	50	2	37157070
Pubmed	Mesenteric Neural Crest Cells Are the Embryological Basis of Skip Segment Hirschsprung's Disease.	NGFR RET SLC17A6	2.25e-06	18	50	3	33340715
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	FBN1 THSD7A SSPOP MUC5AC	3.42e-06	71	50	4	33541421
Pubmed	E3 ubiquitin ligase FBXW7 balances airway cell fates.	MUC5AC NOTCH3 NOTCH4	4.22e-06	22	50	3	34998785
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	THSD7A THSD7B ADAMTSL3 SSPOP	4.26e-06	75	50	4	20637190
Pubmed	Rbpj regulates development of prosensory cells in the mammalian inner ear.	NGFR NOTCH3 NOTCH4	5.54e-06	24	50	3	21420948
Pubmed	Tenascin-C Promotes Tumor Cell Migration and Metastasis through Integrin α9β1-Mediated YAP Inhibition.	TNC ITGB1	6.07e-06	3	50	2	29259017
Pubmed	Transcript level modulates the inherent oncogenicity of RET/PTC oncoproteins.	RET NCOA4	6.07e-06	3	50	2	19487296
Pubmed	Non-canonical Ret signaling augments p75-mediated cell death in developing sympathetic neurons.	NGFR RET	6.07e-06	3	50	2	30018091
Pubmed	Notch receptor expression in human brain arteriovenous malformations.	NOTCH3 NOTCH4	6.07e-06	3	50	2	25846406
Pubmed	Gas1 reduces Ret tyrosine 1062 phosphorylation and alters GDNF-mediated intracellular signaling.	GAS1 RET	6.07e-06	3	50	2	18394855
Pubmed	The platelet glycoprotein Ib-von Willebrand factor interaction activates the collagen receptor alpha2beta1 to bind collagen: activation-dependent conformational change of the alpha2-I domain.	VWF ITGB1	6.07e-06	3	50	2	15514009
Pubmed	Upregulation of alpha 9 integrin and tenascin during epithelial regeneration after debridement in the cornea.	TNC ITGB1	6.07e-06	3	50	2	9016309
Pubmed	Valves of the deep venous system: an overlooked risk factor.	THBD VWF	6.07e-06	3	50	2	19436051
Pubmed	Molecular Profiling of Salivary Gland Intraductal Carcinoma Revealed a Subset of Tumors Harboring NCOA4-RET and Novel TRIM27-RET Fusions: A Report of 17 cases.	RET NCOA4	6.07e-06	3	50	2	30045065
Pubmed	Gas1 is related to the glial cell-derived neurotrophic factor family receptors alpha and regulates Ret signaling.	GAS1 RET	6.07e-06	3	50	2	16551639
Pubmed	Microarray-based mutation detection and phenotypic characterization in Korean patients with retinitis pigmentosa.	PDE6B RP1	6.07e-06	3	50	2	23049240
Pubmed	Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype.	NOTCH3 NOTCH4	6.07e-06	3	50	2	15645445
Pubmed	RET rearrangements are relevant to histopathologic subtypes and clinicopathological features in Thai papillary thyroid carcinoma patients.	RET NCOA4	6.07e-06	3	50	2	37188126
Pubmed	Integrins mediate adhesion of medulloblastoma cells to tenascin and activate pathways associated with survival and proliferation.	TNC ITGB1	6.07e-06	3	50	2	18794852
Pubmed	NCOA4-RET and TRIM27-RET Are Characteristic Gene Fusions in Salivary Intraductal Carcinoma, Including Invasive and Metastatic Tumors: Is "Intraductal" Correct?	RET NCOA4	6.07e-06	3	50	2	31162284
Pubmed	Association of p75(NTR) and α9β1 integrin modulates NGF-dependent cellular responses.	NGFR ITGB1	6.07e-06	3	50	2	25748048
Pubmed	The expression of von Willebrand factor, soluble thrombomodulin, and soluble p-selectin during orthotopic liver transplantation.	THBD VWF	6.07e-06	3	50	2	17275499
Pubmed	Tenascin-C and Integrin α9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment.	TNC ITGB1	6.07e-06	3	50	2	28916657
Pubmed	Novel function of tenascin-C, a matrix protein relevant to atherosclerosis, in platelet recruitment and activation under flow.	TNC ITGB1	6.07e-06	3	50	2	20651280
Pubmed	Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation.	ITGB1 NOTCH3	6.07e-06	3	50	2	29712618
Pubmed	Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development.	NELL1 FAS	6.07e-06	3	50	2	16652108
Pubmed	The C-terminal region of NELL1 mediates osteoblastic cell adhesion through integrin α3β1.	NELL1 ITGB1	6.07e-06	3	50	2	22728432
Pubmed	The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C.	TNC ITGB1	6.07e-06	3	50	2	7541634
Pubmed	Interplay between Ret and Fap-1 regulates CD95-mediated apoptosis in medullary thyroid cancer cells.	RET FAS	6.07e-06	3	50	2	21741956
Pubmed	Identification of the ligand binding site for the integrin alpha9 beta1 in the third fibronectin type III repeat of tenascin-C.	TNC ITGB1	6.07e-06	3	50	2	9565552
Pubmed	Increased levels of endothelial haemostatic markers in patients with coronary heart disease.	THBD VWF	6.07e-06	3	50	2	11864703
Pubmed	A peptide derived from tenascin-C induces beta1 integrin activation through syndecan-4.	TNC ITGB1	6.07e-06	3	50	2	17901052
Pubmed	Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development.	MUC5AC NOTCH3 NOTCH4	7.98e-06	27	50	3	21791528
Pubmed	Notch signaling in stomach epithelial stem cell homeostasis.	MUC5AC NOTCH3 NOTCH4	9.95e-06	29	50	3	21402740
Pubmed	The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors.	NOTCH3 NOTCH4	1.21e-05	4	50	2	24145721
Pubmed	A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma.	NOTCH3 NOTCH4	1.21e-05	4	50	2	20069356
Pubmed	Expression and clinical significance of Notch receptors in human renal cell carcinoma.	NOTCH3 NOTCH4	1.21e-05	4	50	2	19404845
Pubmed	Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas.	TNC ITGB1	1.21e-05	4	50	2	11668187
Pubmed	Notch signaling pathway regulates the growth and the expression of inflammatory cytokines in mouse basophils.	NOTCH3 NOTCH4	1.21e-05	4	50	2	28669409
Pubmed	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	FBN1 FBN3	1.21e-05	4	50	2	25034023
Pubmed	Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression.	MUC5AC NOTCH3	1.21e-05	4	50	2	22691042
Pubmed	Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): evolutionary conservation of multiple expression domains in amphioxus and vertebrates.	NOTCH3 NOTCH4	1.21e-05	4	50	2	11401408
Pubmed	Zic2 is required for enteric nervous system development and neurite outgrowth: a mouse model of enteric hyperplasia and dysplasia.	NGFR RET	1.21e-05	4	50	2	23413832
Pubmed	Functional conservation of mouse Notch receptor family members.	NOTCH3 NOTCH4	1.21e-05	4	50	2	8898100
Pubmed	Perturbation of hoxb5 signaling in vagal neural crests down-regulates ret leading to intestinal hypoganglionosis in mice.	NGFR RET	1.21e-05	4	50	2	18395091
Pubmed	Integrin α6β1 is the main receptor for vascular laminins and plays a role in platelet adhesion, activation, and arterial thrombosis.	VWF ITGB1	1.21e-05	4	50	2	23797810
Pubmed	Expression patterns of neurturin and its receptor components in developing and degenerative mouse retina.	PDE6B RET	1.21e-05	4	50	2	10067959
Pubmed	Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma.	NOTCH3 NOTCH4	1.21e-05	4	50	2	23444212
Pubmed	Deregulated expression of Notch receptors in human hepatocellular carcinoma.	NOTCH3 NOTCH4	1.21e-05	4	50	2	17920003
Pubmed	Prognostic roles of mRNA expression of notch receptors in non-small cell lung cancer.	NOTCH3 NOTCH4	1.21e-05	4	50	2	28061457
Pubmed	CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness.	MEX3A MEX3B	1.21e-05	4	50	2	23408853
Pubmed	A mechanism to safeguard platelet adhesion under high shear flow: von Willebrand factor-glycoprotein Ib and integrin alphabeta-collagen interactions make complementary, collagen-type-specific contributions to adhesion.	VWF ITGB1	1.21e-05	4	50	2	17408410
Pubmed	Evolutionary analysis of vertebrate Notch genes.	NOTCH3 NOTCH4	1.21e-05	4	50	2	11466531
Pubmed	Abnormal expression pattern of Notch receptors, ligands, and downstream effectors in the dorsolateral prefrontal cortex and amygdala of suicidal victims.	NOTCH3 NOTCH4	1.21e-05	4	50	2	24151014
Pubmed	Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation.	NOTCH3 NOTCH4	1.21e-05	4	50	2	10194420
Pubmed	Tenascin-C is an inhibitory boundary molecule in the developing olfactory bulb.	TNC SLC17A6	1.21e-05	4	50	2	19641104
Pubmed	Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.	NOTCH3 NOTCH4	1.21e-05	4	50	2	11459941
Pubmed	MicroRNA-183 suppresses cancer stem-like cell properties in EBV-associated nasopharyngeal carcinoma.	NOTCH3 NOTCH4	1.21e-05	4	50	2	27431799
Pubmed	Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias.	NOTCH3 NOTCH4	1.21e-05	4	50	2	18184405
Pubmed	Notch signaling in the mammalian central nervous system: insights from mouse mutants.	NOTCH3 NOTCH4	1.21e-05	4	50	2	15917835
Pubmed	TBX1 is required for normal stria vascularis and semicircular canal development.	FBN1 NOTCH3 OTOG	1.22e-05	31	50	3	31550482
Pubmed	Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.	NELL1 THBD TNC NOTCH3 SCN3B	1.30e-05	210	50	5	16537572
Pubmed	NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation.	TRAF3 PPP1R13B	2.02e-05	5	50	2	25072696
Pubmed	Targeting the Hprt locus in mice reveals differential regulation of Tie2 gene expression in the endothelium.	THBD VWF	2.02e-05	5	50	2	11015584
Pubmed	ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo.	PPP1R13B FAS	2.02e-05	5	50	2	23365256
Pubmed	Synapse formation during neuron differentiation: an in situ study of the myenteric plexus during murine embryonic life.	NGFR RET	2.02e-05	5	50	2	10972938
Pubmed	Polydom/SVEP1 is a ligand for integrin α9β1.	TNC ITGB1	2.02e-05	5	50	2	22654117
Pubmed	Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system.	VWF NGFR	2.02e-05	5	50	2	1317267
Pubmed	MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.	NOTCH3 NOTCH4	2.02e-05	5	50	2	11101851
Pubmed	Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome.	FBN1 ITGB1	2.02e-05	5	50	2	24531548
Cytoband	10q11.2	RET NCOA4	1.05e-04	14	50	2	10q11.2
Cytoband	15q25.2	ADAMTSL3 MEX3B	1.02e-03	43	50	2	15q25.2
Cytoband	11p15.1	NELL1 OTOG	1.98e-03	60	50	2	11p15.1
GeneFamily	Ring finger proteins	RNF224 MEX3A TRIM28 RNF44 TRIM13 MEX3B RNF182	4.24e-07	275	32	7	58
GeneFamily	CD molecules\|Tumor necrosis factor receptor superfamily\|Death inducing signaling complex	NGFR FAS	1.20e-03	29	32	2	782
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	THBD NGFR FAS ITGB1	4.93e-03	394	32	4	471
GeneFamily	Ankyrin repeat domain containing	PPP1R13B NOTCH3 NOTCH4	8.82e-03	242	32	3	403
GeneFamily	PHD finger proteins	PHF1 TRIM28	1.10e-02	90	32	2	88
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM28 TRIM13	1.22e-02	95	32	2	59
Coexpression	NABA_ECM_GLYCOPROTEINS	NELL1 FBN1 VWF CRIM1 TNC KCP SSPOP FBN3 OTOG	1.17e-10	196	50	9	M3008
Coexpression	NABA_CORE_MATRISOME	NELL1 FBN1 VWF CRIM1 TNC KCP SSPOP FBN3 OTOG	2.33e-09	275	50	9	M5884
Coexpression	NABA_ECM_GLYCOPROTEINS	NELL1 FBN1 VWF CRIM1 TNC KCP SSPOP OTOG	2.84e-09	191	50	8	MM17059
Coexpression	NABA_CORE_MATRISOME	NELL1 FBN1 VWF CRIM1 TNC KCP SSPOP OTOG	4.22e-08	270	50	8	MM17057
Coexpression	NABA_MATRISOME	NELL1 FBN1 VWF CRIM1 TNC OGFOD2 KCP ADAMTSL3 SSPOP MUC5AC FBN3 OTOG	3.72e-07	1026	50	12	M5889
Coexpression	JONES_OVARY_NK_CELL	FBN1 CRIM1 ITGB1 NOTCH3 NOTCH4	7.57e-07	89	50	5	M48353
Coexpression	GSE6092_UNSTIM_VS_IFNG_STIM_AND_B_BURGDORFERI_INF_ENDOTHELIAL_CELL_DN	THBD FBN1 KCP RP1 THSD7B NOTCH4	2.20e-06	200	50	6	M6715
Coexpression	NABA_MATRISOME	NELL1 FBN1 VWF CRIM1 TNC OGFOD2 KCP ADAMTSL3 SSPOP MUC5AC OTOG	2.43e-06	1008	50	11	MM17056
Coexpression	GSE22601_DOUBLE_NEGATIVE_VS_CD8_SINGLE_POSITIVE_THYMOCYTE_DN	VWF PPP1R13B RP1 SSPOP SLC17A6	3.76e-05	198	50	5	M6230
Coexpression	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	FBN1 TNC GAS1 FAS ITGB1	3.94e-05	200	50	5	M5930
Coexpression	HAY_BONE_MARROW_STROMAL	FBN1 CRIM1 TNC GAS1 NGFR THSD7B ADAMTSL3 NOTCH3	9.38e-05	767	50	8	M39209
Coexpression	ATM_DN.V1_UP	CLCN6 NGFR RET SLC5A2	1.74e-04	146	50	4	M2692
Coexpression	KRAS.600_UP.V1_DN	THBD FCGBP PDE6B MUC5AC SLC5A2	1.89e-04	279	50	5	M2880
Coexpression	GERHOLD_ADIPOGENESIS_DN	THBD GAS1 ITGB1	2.28e-04	62	50	3	M1576
Coexpression	GERHOLD_ADIPOGENESIS_DN	THBD GAS1 ITGB1	2.51e-04	64	50	3	MM671
Coexpression	JONES_OVARY_ENDOTHELIAL	VWF CRIM1 ITGB1 NOTCH4	2.59e-04	162	50	4	M48350
Coexpression	INAMURA_LUNG_CANCER_SCC_DN	VWF ADAMTSL3	2.74e-04	13	50	2	M1255
Coexpression	MCMURRAY_TP53_HRAS_COOPERATION_RESPONSE_DN	FAS NOTCH3 SCN3B	2.87e-04	67	50	3	M9325
Coexpression	GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP	TRAF3 TNC ITGB1	3.00e-04	68	50	3	M1373
Coexpression	HEBERT_MATRISOME_TNBC_LIVER_METASTASIS	VWF TNC	3.20e-04	14	50	2	M48002
Coexpression	JONES_OVARY_PERICYTE	FBN1 CRIM1 ITGB1 NOTCH3	3.26e-04	172	50	4	M48351
Coexpression	MCMURRAY_TP53_HRAS_COOPERATION_RESPONSE_DN	FAS NOTCH3 SCN3B	3.27e-04	70	50	3	MM809
Coexpression	GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP	TRAF3 TNC ITGB1	3.55e-04	72	50	3	MM1131
Coexpression	ZHANG_RESPONSE_TO_CANTHARIDIN_UP	TRAF3 TRIM13	3.69e-04	15	50	2	M14118
Coexpression	GAO_LARGE_INTESTINE_ADULT_CJ_IMMUNE_CELLS	THBD FBN1 VWF CHST7 NOTCH3 NOTCH4	3.85e-04	505	50	6	M39167
Coexpression	FUKUSHIMA_TNFSF11_TARGETS	NOTCH3 NOTCH4	4.21e-04	16	50	2	MM1296
Coexpression	FUKUSHIMA_TNFSF11_TARGETS	NOTCH3 NOTCH4	4.21e-04	16	50	2	M2207
Coexpression	GSE21546_UNSTIM_VS_ANTI_CD3_STIM_SAP1A_KO_AND_ELK1_KO_DP_THYMOCYTES_UP	THSD7B TRIM13 SLC17A6 SLC5A2	4.65e-04	189	50	4	M7539
Coexpression	TABULA_MURIS_SENIS_MESENTERIC_ADIPOSE_TISSUE_ENDOTHELIAL_CELL_AGEING	THBD CRIM1 RNF44	4.66e-04	79	50	3	MM3780
Coexpression	GSE46606_DAY1_VS_DAY3_CD40L_IL2_IL5_STIMULATED_BCELL_UP	FCGBP THSD7A RDM1 NCOA4	4.75e-04	190	50	4	M9871
Coexpression	WIERENGA_STAT5A_TARGETS_DN	VWF DCLRE1A PLCB2 CAMK1	5.04e-04	193	50	4	M2213
Coexpression	GSE1791_CTRL_VS_NEUROMEDINU_IN_T_CELL_LINE_0.8H_DN	PPP1R13B CAMK1 MEX3B NOTCH3	5.13e-04	194	50	4	M6163
Coexpression	HE_LIM_SUN_FETAL_LUNG_C0_PERICYTE	NGFR KCP ADAMTSL3 NOTCH3	5.23e-04	195	50	4	M45684
Coexpression	GSE22886_IGA_VS_IGM_MEMORY_BCELL_UP	VWF FAS ITGB1 NOTCH3	5.34e-04	196	50	4	M4437
Coexpression	GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_10H_UP	PHF1 THBD TRAF3 MEX3B	5.54e-04	198	50	4	M4293
Coexpression	GSE1566_WT_VS_EZH2_KO_LN_TCELL_DN	TRAF3 PPP1R13B RP1 SLC17A6	5.54e-04	198	50	4	M6224
Coexpression	GSE36392_EOSINOPHIL_VS_NEUTROPHIL_IL25_TREATED_LUNG_DN	NGFR CHST7 OTOG SLC5A2	5.65e-04	199	50	4	M5284
Coexpression	MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED	PHF1 THBD MEX3A KCP THSD7B NCOA4	5.69e-04	544	50	6	M1936
Coexpression	GSE369_PRE_VS_POST_IL6_INJECTION_SOCS3_KO_LIVER_DN	FCGBP FMO5 TRIM28 CAMK1	5.76e-04	200	50	4	M5977
Coexpression	GSE24726_WT_VS_E2_2_KO_PDC_DAY6_POST_DELETION_DN	THBD DCLRE1A CAMK1 SCN3B	5.76e-04	200	50	4	M8056
Coexpression	GSE28737_WT_VS_BCL6_HET_FOLLICULAR_BCELL_UP	NELL1 FMO5 PPP1R13B SLC17A6	5.76e-04	200	50	4	M9391
Coexpression	GSE15750_DAY6_VS_DAY10_EFF_CD8_TCELL_DN	PHF1 CRIM1 CLCN6 PPP1R13B	5.76e-04	200	50	4	M3579
Coexpression	GSE5542_UNTREATED_VS_IFNA_TREATED_EPITHELIAL_CELLS_6H_UP	FMO5 CRIM1 FAS ITGB1	5.76e-04	200	50	4	M6514
Coexpression	GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_DN	THBD FAS CHST7 MEX3B	5.76e-04	200	50	4	M6000
Coexpression	GSE16450_IMMATURE_VS_MATURE_NEURON_CELL_LINE_12H_IFNA_STIM_UP	PHF1 CRIM1 CARNS1 MEX3B	5.76e-04	200	50	4	M7430
Coexpression	HEVNER_CORTEX_VASCULAR_ENDOTHELIAL_CELLS	VWF NOTCH4	5.97e-04	19	50	2	MM420
ToppCell	facs-Heart-LV-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 THSD7A GAS1 KCP RET ADAMTSL3 NOTCH3	1.90e-09	191	50	7	b7a57691a4742070cee640e285c1f4d0da95baf1
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBD VWF THSD7A PPP1R13B CHST7 NOTCH4 SCN3B	1.98e-09	192	50	7	0aeb5351275c0a91151ea2d52b2cdde172da6731
ToppCell	facs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 THSD7A GAS1 KCP RET ADAMTSL3	7.59e-08	192	50	6	671d4e1eee5aba03c43dbc98f4b51ce42b3df5d5
ToppCell	facs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 THSD7A GAS1 KCP RET ADAMTSL3	7.59e-08	192	50	6	840a34c1b82d218be999ab5e1bcafd6370d7a4b1
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature-endo_immature_arterial1_(12)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	THBD VWF THSD7B CHST7 NOTCH4 SCN3B	7.83e-08	193	50	6	d338a7c0585b69947c37f44aa0381619493e31ea
ToppCell	ILEUM-inflamed-(7)_CD36+_endothelial_cells\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	NELL1 THBD VWF THSD7A CRIM1 NOTCH4	9.11e-08	198	50	6	05d6558c7990ad2277db999025a073d29b273dfc
ToppCell	ILEUM-non-inflamed-(7)_CD36+_endothelial_cells\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	NELL1 THBD VWF THSD7A CRIM1 NOTCH4	9.66e-08	200	50	6	45755a597725015dc3ee36f9166f9e82f6f9c603
ToppCell	ILEUM-non-inflamed-(7)_Endothelial_cell\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	NELL1 THBD VWF THSD7A CRIM1 NOTCH4	9.66e-08	200	50	6	ec92fe4eafe527d351ee73c9735e96855ac506a3
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-mLTo\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THBD TRAF3 TNC NGFR NOTCH3	9.06e-07	157	50	5	c779a53b2c67d566f5d417e753cd17196a6bfd1c
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-5\|TCGA-Bladder / Sample_Type by Project: Shred V9	NELL1 MEX3B FBN3 OTOG SLC17A6	1.30e-06	169	50	5	9c4e83fe8225d16173a103bf5a57b17d623be923
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	THBD TRAF3 FAS NOTCH4 SCN3B	1.50e-06	174	50	5	b4f3f5334803e5903bc496decf923f2e44f7fa3c
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THBD VWF THSD7A CRIM1 RET	1.93e-06	183	50	5	fc9a7ba148c22d0c8a46f6bc56c772929ac496f7
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	VWF PPP1R13B CHST7 NOTCH4 SCN3B	2.03e-06	185	50	5	808d5e880069aff8866cd2c733b9fe568a37701f
ToppCell	COVID-19_Convalescent-PLT_4\|World / Disease Group and Platelet Clusters	TSPAN10 OGFOD2 DCLRE1A CHST7 MEX3B	2.08e-06	186	50	5	5954a1e3ffafb33f2a9bc87af3343f304fda4c92
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TNC NGFR RET ITGB1 NOTCH3	2.14e-06	187	50	5	d591a3c216997663ab77710fed0d230ffc37e41a
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CRIM1 KCP THSD7B ADAMTSL3 NOTCH3	2.14e-06	187	50	5	fa01a61bfd13feb033ba1e35cf513707b1bff8c8
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TNC NGFR RET ITGB1 NOTCH3	2.14e-06	187	50	5	d1dc8c9a2c2cd10c640257161a75e7730ec5bb41
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TNC NGFR RET ITGB1 NOTCH3	2.14e-06	187	50	5	ac8e092b37e042975e2ee057d3f7c6821e58e8b5
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBD VWF CHST7 NOTCH4 SCN3B	2.14e-06	187	50	5	dffa8447c2f3fdacf39a7258c6b4e81a25245041
ToppCell	droplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 VWF THSD7A THSD7B NOTCH4	2.14e-06	187	50	5	e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCell	E17.5-Endothelial-large_vessel_endothelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	NELL1 FBN1 VWF FMO5 THSD7A	2.25e-06	189	50	5	360f09f46231a83f99d8fa0158b72a38068e1642
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THBD VWF THSD7A FAS NOTCH4	2.25e-06	189	50	5	1e1afa66b32ae752c0a42b02b80f10205464569c
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Artery\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 VWF THSD7A RP1 NOTCH4	2.31e-06	190	50	5	aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCell	21-Trachea-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	THBD VWF GAS1 CHST7 NOTCH4	2.31e-06	190	50	5	bce09634acbc2cfd53666328e8aed8bf8835f845
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THBD VWF THSD7A CRIM1 ITGB1	2.31e-06	190	50	5	9b0ad888eb20acc011904d8593bc32bdef18d050
ToppCell	21-Trachea-Endothelial-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	THBD VWF GAS1 CHST7 NOTCH4	2.31e-06	190	50	5	08437396a98ca9526f69c3a74bbf2929f3c68b8e
ToppCell	PCW_05-06-Endothelial-Endothelial_immature-endo_immature2_(1)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	THBD VWF CHST7 NOTCH4 SCN3B	2.44e-06	192	50	5	f68e6cbde87678122da1b5c0061904cfb7d04bf5
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THBD VWF THSD7A CRIM1 ITGB1	2.44e-06	192	50	5	c157981b9a179925edcaabc0cb3b8805f0929004
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBD VWF THSD7A NOTCH4 SCN3B	2.50e-06	193	50	5	e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCell	PCW_07-8.5-Endothelial-Endothelial_cycling-endo_proliferating3_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	THBD VWF THSD7B NOTCH4 SCN3B	2.50e-06	193	50	5	72128ece598070f8e752a0691e024e26ab364989
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature-endo_immature4_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	THBD VWF THSD7B NOTCH4 SCN3B	2.50e-06	193	50	5	72d20ee257149b238016b44d183ce3fc24b8f621
ToppCell	390C-Endothelial_cells-Endothelial-B_(Artery)\|390C / Donor, Lineage, Cell class and subclass (all cells)	THBD VWF THSD7A CRIM1 NOTCH4	2.56e-06	194	50	5	f8a59bd4609d147d8a706bf606e9e8173c9992a3
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature-endo_immature1_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	THBD VWF THSD7B NOTCH4 SCN3B	2.56e-06	194	50	5	2e3a64bda7c76fd0c99e93de0215f236e8045d83
ToppCell	PCW_07-8.5-Endothelial-Endothelial_mature\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	THBD VWF THSD7B NOTCH4 SCN3B	2.56e-06	194	50	5	8c88a0ddd61ad900426e312ca4ab13061c0380b8
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MEX3A THSD7A MEX3B SCN3B SLC17A6	2.56e-06	194	50	5	4e93bd903cddfd0c8f220b6a35b449895de4119b
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature-endo_immature2_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	THBD VWF CHST7 NOTCH4 SCN3B	2.56e-06	194	50	5	760f98bbcb669e599c389ef7892043eee3a05edf
ToppCell	390C-Endothelial_cells-Endothelial-B_(Artery)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	THBD VWF THSD7A CRIM1 NOTCH4	2.56e-06	194	50	5	04b1acc2e879feafb43f75435281c5acd8d23be2
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	VWF CRIM1 PPP1R13B CHST7 NOTCH4	2.63e-06	195	50	5	56efeb58df19f357d7d5ce87348d4f196a595421
ToppCell	PCW_07-8.5-Endothelial\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	THBD VWF THSD7B NOTCH4 SCN3B	2.63e-06	195	50	5	f2cc94d5e1652203ca38bea57f37d3deec73ef04
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	THBD VWF THSD7B NOTCH4 SCN3B	2.63e-06	195	50	5	c7abcb674e4a25a5354c4947fffd0d17bc8c1fab
ToppCell	PCW_13-14-Endothelial\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	THBD VWF THSD7B NOTCH4 SCN3B	2.69e-06	196	50	5	7286de29a34e13834cd6347c67a1443897fa4ade
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature1_(0)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	THBD VWF THSD7B NOTCH4 SCN3B	2.69e-06	196	50	5	29ed8b1c4cd730db8632fde6eece404f1883a86d
ToppCell	PCW_10-12-Endothelial-Endothelial_immature\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	THBD VWF THSD7B NOTCH4 SCN3B	2.69e-06	196	50	5	c65b8c7ea34a21897c390e6fb42ee8ca41e9c976
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature2_(1)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	THBD VWF THSD7B NOTCH4 SCN3B	2.69e-06	196	50	5	0e8d649b50be2d707510b897bb97767b5847dff9
ToppCell	PCW_10-12-Endothelial\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	THBD VWF THSD7B NOTCH4 SCN3B	2.69e-06	196	50	5	2c60dcf9132ee156f25b349e2ac5313709def4f6
ToppCell	3'-Child09-12-SmallIntestine-Endothelial\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THBD VWF THSD7A NOTCH4 SCN3B	2.76e-06	197	50	5	86a02fd7b4762b3278e5e60b5483b5fc1206e597
ToppCell	390C-Endothelial_cells\|390C / Donor, Lineage, Cell class and subclass (all cells)	THBD VWF THSD7A CRIM1 NOTCH4	2.76e-06	197	50	5	aa381acea0f7882d39435a6f713386bf0588b5f8
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FBN1 TNC GAS1 NGFR ADAMTSL3	2.83e-06	198	50	5	9541d68a1a6247dbd7161a62644eea6527c2c8ff
ToppCell	3'-Pediatric_IBD-SmallIntestine-Endothelial-blood_vessel_EC\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THBD VWF THSD7A CRIM1 NOTCH4	2.83e-06	198	50	5	5b86dc00acf8ac2ede008f5d79c09996485bf250
ToppCell	5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THBD VWF THSD7A CRIM1 NOTCH4	2.83e-06	198	50	5	d1f54ed3ef5e05ebda7da999e172d168dc6802cd
ToppCell	5'-Adult-Distal_Rectal-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THBD VWF THSD7A CRIM1 NOTCH4	2.83e-06	198	50	5	8d6b0b9da7c1e64155cbcbb04ad38d129a29030c
ToppCell	Tracheal-NucSeq-Endothelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	THBD VWF THSD7A NOTCH4 SCN3B	2.83e-06	198	50	5	77e31b6edeeb5ccd5cd3f080898c96bf9ab9f98d
ToppCell	3'-Pediatric_IBD-SmallIntestine-Endothelial\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THBD VWF THSD7A CRIM1 NOTCH4	2.83e-06	198	50	5	13203249e5743ba2699871c184d141207e550a86
ToppCell	Transplant_Alveoli_and_parenchyma-Endothelial\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	VWF THSD7A CRIM1 NOTCH4 SCN3B	2.83e-06	198	50	5	56b746e5791b47fe33a7872f0942ae0747b13d4a
ToppCell	5'-Adult-Appendix-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THBD VWF THSD7A NOTCH4 SCN3B	2.83e-06	198	50	5	90e85fe7a0ab376a41666dfff6c0e95b7f1c9475
ToppCell	ILEUM-inflamed-(7)_Endothelial_cell\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	NELL1 VWF THSD7A CRIM1 NOTCH4	2.90e-06	199	50	5	97052c28e354833901f28d339b09f97f50a5b752
ToppCell	Lung_Parenchyma-Severe-Myeloid-Macrophage-Macrophages-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	THBD VWF THSD7A CRIM1 NOTCH4	2.97e-06	200	50	5	e6d36be0c4c569e27303bb4e4f34cd2187e9759d
ToppCell	Parenchyma_COVID-19-Endothelial-TX\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	THBD VWF THSD7A CRIM1 NOTCH4	2.97e-06	200	50	5	abcbd5a156aa4fd51d284441388975c81c0b88ae
ToppCell	Parenchyma_COVID-19-Endothelial-TX-Macrophages\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	THBD VWF THSD7A CRIM1 NOTCH4	2.97e-06	200	50	5	c0c51719cf81512c50bfcc2fed883c867e522d2a
ToppCell	Lung_Parenchyma-Severe-Endothelial\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	THBD VWF THSD7A CRIM1 NOTCH4	2.97e-06	200	50	5	d9d0ffa18e5b4647966e19ad9830cbba6120677e
ToppCell	Lung_Parenchyma-Severe-Myeloid-Macrophage\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	THBD VWF THSD7A CRIM1 NOTCH4	2.97e-06	200	50	5	758840c31f2ddd7ccf7bf13252ebb48d33e89479
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	THBD VWF THSD7A CRIM1 NOTCH4	2.97e-06	200	50	5	e9d5ba140cabae11c437012d519b85f5412dcc94
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THBD VWF THSD7A PPP1R13B NOTCH4	2.97e-06	200	50	5	90061284a80d29a4ca6078f578e13d32b8cc80e1
ToppCell	Lung_Parenchyma-Severe-Myeloid-Macrophage-Macrophages\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	THBD VWF THSD7A CRIM1 NOTCH4	2.97e-06	200	50	5	c37fe06a94e5779c56e01389869bb432d3bbaebc
ToppCell	(54)_pDC\|World / shred on Cell_type and subtype	NELL1 THBD NGFR RET NOTCH4	3.20e-06	203	50	5	b8ba3e51770ff7b45cd02472f3e63aa4d5816f6f
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Col3a1_(Mural.Rgs5Acta2.Col3a1)-\|Striatum / BrainAtlas - Mouse McCarroll V32	THBD FBN1 CHST7 NOTCH3	1.56e-05	134	50	4	a3547a68012d879d4dfe80394eace70808722e43
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Col3a1_(Mural.Rgs5Acta2.Col3a1)\|Striatum / BrainAtlas - Mouse McCarroll V32	THBD FBN1 CHST7 NOTCH3	1.56e-05	134	50	4	9458e2d0dbc18d9025b66b59f3ecc2fbc5384940
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Pltp\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NELL1 THSD7A THSD7B RET	1.80e-05	139	50	4	9e9f29f92dbe65b26cc78b3a1c00778c6a701f5b
ToppCell	E16.5-samps-Mesenchymal-Pericyte\|E16.5-samps / Age Group, Lineage, Cell class and subclass	CRIM1 PPP1R13B ADAMTSL3 NOTCH3	2.30e-05	148	50	4	e697a7fb037873c9b11703d1bf836a69fc276e23
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF224 FCGBP SSPOP RNF182	2.30e-05	148	50	4	f58804d24fe524b42b5090c8658050ea4b14793e
ToppCell	E16.5-samps-Mesenchymal-Pericyte-pericyte_A\|E16.5-samps / Age Group, Lineage, Cell class and subclass	CRIM1 PPP1R13B ADAMTSL3 NOTCH3	2.30e-05	148	50	4	c87fe2373418ec0cfe37279003d1c4df4c0d0aac
ToppCell	PND07-28-samps-Mesenchymal-Pericyte-pericyte_F\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	FMO5 CRIM1 ADAMTSL3 NOTCH3	2.43e-05	150	50	4	2d0d6dc07dcfe28e3d7694c52d15d17dae2fd47b
ToppCell	PND07-28-samps-Mesenchymal-Pericyte\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	FMO5 CRIM1 ADAMTSL3 NOTCH3	2.43e-05	150	50	4	5b111ec11a642d63fafa7e1422e36f81a2776531
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MEX3A VWF THSD7A NOTCH4	2.90e-05	157	50	4	275a4c6fef1fff8da2bdc48e3924ad05c5e5cfc8
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D231\|Adult / Lineage, Cell type, age group and donor	CRIM1 TNC CAMK1 NOTCH3	2.97e-05	158	50	4	8d64c0c9de910a3f4658778642d183c8b9b6f6a2
ToppCell	NS-critical-d_16-33-Myeloid-Mast_cell\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NELL1 THSD7A CAMK1 SCN3B	3.12e-05	160	50	4	c61869d9dbba250270e59366e15af204e5b4395d
ToppCell	Basal_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	MEX3A TNC NGFR THSD7B	3.44e-05	164	50	4	85487a303194f5244956ec1ca2d1758d38117f41
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBN1 TNC GAS1 NGFR	3.52e-05	165	50	4	4e13fccd32029e2879e85f8966e582a46c09e4aa
ToppCell	Mild-Myeloid-Mast\|Mild / Condition, Lineage, Cell class and cell subclass	VWF THSD7A RET MEX3B	3.52e-05	165	50	4	5fa9552c37890c5cc7e672a47038aebba2413cb4
ToppCell	Mild-Myeloid-Mast-\|Mild / Condition, Lineage, Cell class and cell subclass	VWF THSD7A RET MEX3B	3.52e-05	165	50	4	93d3909a0f5f43d473d5005c842d7d73e25eceed
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF THSD7A CRIM1 NOTCH4	3.61e-05	166	50	4	7a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF THSD7A CRIM1 NOTCH4	3.61e-05	166	50	4	bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCell	Healthy_donor-HSPC\|World / disease group, cell group and cell class (v2)	MEX3A TNC MEX3B NOTCH3	3.69e-05	167	50	4	70630ebdfee8171d625811844f8a7c94736d101e
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBN1 TNC GAS1 NGFR	3.69e-05	167	50	4	fe3338f99f94c0dac37e3d649dfdce82e4a56022
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD8-Tnaive/CM_CD8\|GI_small-bowel / Manually curated celltypes from each tissue	FMO5 CLCN6 PDE6B SLC5A2	3.78e-05	168	50	4	c51244b4bdbfd961e2725306aa9cb25dd66d58bd
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THBD VWF THSD7A RET	3.87e-05	169	50	4	58136b8a0bf2dab45c91a053ef7225ea49ccb871
ToppCell	facs-Heart-LV-18m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 THSD7A GAS1 ADAMTSL3	3.87e-05	169	50	4	849a8f8509c58d65462a09c84d58b6ecdc8934f5
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THBD VWF THSD7A RET	3.87e-05	169	50	4	04c6ed38e1d1befba5ef5f37a3c1e045a0b163d6
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-mLTo\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THBD TNC NGFR NOTCH3	3.87e-05	169	50	4	559e98216720e4babf0b0941100f1b485c35b11b
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	VWF THSD7A CARNS1 NOTCH4	4.05e-05	171	50	4	1597459c971d6befa991d59dc66b41b6a522f797
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THBD VWF CRIM1 ITGB1	4.14e-05	172	50	4	fc092a0631555d79e00ef9890cbd806e15bca2d4
ToppCell	Adult-Mesenchymal-pericyte_cell-D231\|Adult / Lineage, Cell type, age group and donor	CRIM1 KCP ADAMTSL3 NOTCH3	4.14e-05	172	50	4	858cee96c1c06160863b4adcd7023c0d678bd50f
ToppCell	Healthy_donor-HSPC\|Healthy_donor / disease group, cell group and cell class (v2)	MEX3A TNC MEX3B NOTCH3	4.14e-05	172	50	4	bc7549faadfc92c683c0e26bea380458706774b5
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THBD VWF CRIM1 ITGB1	4.14e-05	172	50	4	745725bd10c82017d678463b8fef0d2dcf09a8fd
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D122\|Adult / Lineage, Cell type, age group and donor	FBN1 THSD7A CRIM1 SCN3B	4.24e-05	173	50	4	dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCell	facs-Lung-Endomucin-24m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 PDE6B ADAMTSL3 NOTCH3	4.24e-05	173	50	4	a37f38478473290fe35aea8684befc3bf95b161f
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	VWF THSD7A NOTCH4 SCN3B	4.33e-05	174	50	4	cb0109661e8c9ca04d67d33f2d926f0e649bf67d
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NELL1 VWF THSD7A ITGB1	4.43e-05	175	50	4	2e54961846c65b185d9bd6e305dd81205579d890
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 NGFR RET NOTCH3	4.43e-05	175	50	4	1b4cefae400bf756d09ece32d3f5c0bd4c6ad73f
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CRIM1 ADAMTSL3 SSPOP NOTCH3	4.43e-05	175	50	4	2a53d4f140d5ab096efe8118d8aa351db7838b49
Computational	ECM and collagens.	FBN1 VWF THSD7A TNC GAS1 NOTCH3	5.43e-05	225	33	6	MODULE_47
Computational	Placenta genes.	FCGBP VWF CRIM1 GAS1 PLCB2 NOTCH3 SLC5A2	4.24e-04	463	33	7	MODULE_38
Computational	Metal / Ca ion binding.	NELL1 THBD FBN1 RET	6.94e-04	133	33	4	MODULE_324
Computational	Ovary genes.	FBN1 VWF CRIM1 TNC GAS1 NOTCH3	7.82e-04	368	33	6	MODULE_1
Computational	Adhesion molecules.	NELL1 FBN1 VWF TNC	8.64e-04	141	33	4	MODULE_122
Computational	DRG (dorsal root ganglia) genes.	FBN1 VWF CRIM1 TNC NGFR NOTCH3	9.76e-04	384	33	6	MODULE_2
Computational	Genes in the cancer module 311.	VWF TNC	1.36e-03	18	33	2	MODULE_311
Computational	Trachea genes.	FCGBP VWF CRIM1 TNC GAS1 NOTCH3	1.46e-03	415	33	6	MODULE_6
Drug	(-)-MK 801 hydrogen maleate [77086-19-2]; Down 200; 11.8uM; PC3; HT_HG-U133A	PHF1 TRAF3 GALK2 TNC ITGB1 SLC5A2	4.63e-06	198	50	6	6657_DN
Drug	Altretamine [654-05-6]; Up 200; 19uM; MCF7; HT_HG-U133A	FBN1 FMO5 PDE6B FAS ADAMTSL3 MUC5AC	4.63e-06	198	50	6	6467_UP
Drug	Rgd Peptide	THBD FBN1 VWF TNC ITGB1 FBN3	1.36e-05	239	50	6	CID000104802
Disease	connective tissue disease (implicated_via_orthology)	FBN1 FBN3	7.44e-06	3	47	2	DOID:65 (implicated_via_orthology)
Disease	familial combined hyperlipidemia (is_marker_for)	THBD VWF	3.71e-05	6	47	2	DOID:13809 (is_marker_for)
Disease	Squamous cell carcinoma	FAS ITGB1 NOTCH3 NOTCH4	4.61e-05	124	47	4	C0007137
Disease	cigarettes per day measurement	PHF1 THSD7A PPP1R13B PLCB2 THSD7B RET	6.63e-05	438	47	6	EFO_0006525
Disease	cancer (implicated_via_orthology)	TSPAN10 RET ITGB1 NOTCH3 NOTCH4	6.69e-05	268	47	5	DOID:162 (implicated_via_orthology)
Disease	mesangial proliferative glomerulonephritis (biomarker_via_orthology)	FBN1 VWF	6.91e-05	8	47	2	DOID:4783 (biomarker_via_orthology)
Disease	bringing up phlegm, sputum or mucus on most days, self-reported	NELL1 MUC5AC	8.88e-05	9	47	2	EFO_0009824
Disease	body weight	NELL1 TRAF3 MEX3A CRIM1 THSD7B RET TRIM13 FAS ADAMTSL3	1.45e-04	1261	47	9	EFO_0004338
Disease	Hirschsprung's disease (implicated_via_orthology)	RET ITGB1	1.62e-04	12	47	2	DOID:10487 (implicated_via_orthology)
Disease	interstitial lung disease	THSD7B MUC5AC NOTCH4	1.69e-04	67	47	3	EFO_0004244
Disease	dermatomyositis (is_marker_for)	THBD FAS	3.33e-04	17	47	2	DOID:10223 (is_marker_for)
Disease	serum iron measurement	NELL1 GALK2 NOTCH4	3.53e-04	86	47	3	EFO_0006332
Disease	glaucoma (is_marker_for)	FAS MUC5AC	4.63e-04	20	47	2	DOID:1686 (is_marker_for)
Disease	glomerulonephritis (biomarker_via_orthology)	FBN1 ITGB1	4.63e-04	20	47	2	DOID:2921 (biomarker_via_orthology)
Disease	gastric ulcer (biomarker_via_orthology)	FAS MUC5AC	5.12e-04	21	47	2	DOID:10808 (biomarker_via_orthology)
Disease	pancreatic cancer (is_marker_for)	NGFR RET MUC5AC	5.66e-04	101	47	3	DOID:1793 (is_marker_for)
Disease	Sjogren's syndrome (is_marker_for)	FAS MUC5AC	6.70e-04	24	47	2	DOID:12894 (is_marker_for)
Disease	Carcinoma, Pancreatic Ductal	NOTCH3 NOTCH4	6.70e-04	24	47	2	C0887833
Disease	systemic scleroderma (is_implicated_in)	FBN1 NOTCH4	6.70e-04	24	47	2	DOID:418 (is_implicated_in)
Disease	Colorectal Carcinoma	NELL1 TRIM28 RET ADAMTSL3 RNF182 SCN3B	8.31e-04	702	47	6	C0009402
Disease	phosphatidylcholine measurement	PHF1 NELL1 THSD7B NOTCH4	1.08e-03	284	47	4	EFO_0010226
Disease	Thyroid Gland Follicular Adenoma	RET NCOA4	1.43e-03	35	47	2	C0151468
Disease	facial emotion recognition measurement	TRAF3 THSD7A	1.43e-03	35	47	2	EFO_0008329
Disease	triacylglycerol 58:8 measurement	GAS1 NGFR	1.43e-03	35	47	2	EFO_0010442
Disease	pulse pressure measurement	FBN1 CRIM1 CLCN6 DCLRE1A FAS ADAMTSL3 SSPOP NOTCH3	1.46e-03	1392	47	8	EFO_0005763

Protein segments in the cluster

Peptide	Gene	Start	Entry
AVPCCPLESEADVER	CARNS1	526	A5YM72
CTDIDECRISPDLCG	FBN3	1026	Q75N90
RPPSAVACEDCSCRD	DPH1	421	Q9BZG8
PITPETTCRDVVEFC	PPP1R13B	21	Q96KQ4
ICECECQSEGIPESP	ITGB1	461	P05556
CALEVVLPSCDCRSP	RDM1	161	Q8NG50
LCPMCCREPDLVDDE	OGFOD2	316	Q6N063
PPDCDSLRDLCQVEE	PDE6B	41	P35913
ECSCPELDQLVDICR	GALK2	376	Q01415
PRCETDVNECLSGPC	NOTCH3	426	Q9UM47
DCVCDGLERPICESV	GAS1	221	P54826
CESPRSVECRAEDAP	MUC5AC	1421	P98088
PSADLFCCPECDTRV	NELL1	676	Q92832
CRDCCVEPGTELSPT	CAMK1	351	Q14012
DPCKVEEVCRANEPC	NCOA4	396	Q13772
CCCGERETRTPEELT	CLCN6	16	P51797
ECRGSCPTCPEDRLE	FCGBP	1856	Q9Y6R7
DECRGSCPTCPEDRL	FCGBP	3056	Q9Y6R7
CEDIDECSTIPGICE	FBN1	286	P35555
CCVEEGLEPVCFERT	FMO5	21	P49326
VCLPCDESKCEEPRN	CRIM1	36	Q9NZV1
ECCPVCEEPTIITVD	CRIM1	451	Q9NZV1
VFECLDSPPRSETEC	DCLRE1A	141	Q6PJP8
KSCECDCDTIPVPRC	OTOG	2641	Q6ZRI0
APEVCVLEVTCSPCE	RP1	1246	P56715
EELLCCVCRSETVVP	PHF1	86	O43189
ECANRICEKSEPECP	MEX3B	541	Q6ZN04
ICEKSEPECPVCHTA	MEX3B	546	Q6ZN04
ECVEPVDPCFRANCE	THBD	361	P07204
EEMVLEPGSCCPSCR	SSPOP	5031	A2VEC9
RVCKLPCPEDCVISE	THSD7A	1156	Q9UPZ6
GEVSCEEQECPVTPC	KCP	401	Q6ZWJ8
GPPEERTDCIICCSA	RNF224	16	P0DH78
VIVCPFCRFETCLPD	RNF182	61	Q8N6D2
CQTEVDECLSDPCPV	NOTCH4	586	Q99466
EDTACERSCPPVAIR	CHST7	221	Q9NS84
EVPERKAPLCDCTCF	SLC17A6	51	Q9P2U8
KHEDTDCPCVVVSCP	TRAF3	191	Q13114
EDLTCPICCSLFDDP	TRIM13	6	O60858
LLQTCVDPEDCPVCE	VWF	1186	P04275
DEVACVVPEVCRRVC	SLC5A2	341	P31639
RDCTVNGDEPDCVPC	FAS	71	P25445
VDPCLPCTVCEDTER	NGFR	161	P08138
PCTVCEDTERQLREC	NGFR	166	P08138
RICERTDPECPVCHI	MEX3A	496	A1L020
TCPICRADASEVPRE	RNF44	416	Q7L0R7
DCSREICPVPCSEEH	TNC	246	P24821
VCFPVCVEVPSETEA	SCN3B	21	Q9NY72
DKPERACECPPELCE	PLCB2	1156	Q00722
EKCFCEPEDIQDPLC	RET	616	P07949
ACSLPASCCIDPRED	TSPAN10	236	Q9H1Z9
ACLIPCPRDCVVSEF	THSD7B	171	Q9C0I4
CVECSEPLCETCVEA	TRIM28	166	Q13263
TERPCLLEACDESPA	ADAMTSL3	616	P82987