Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionalkenylglycerophosphocholine hydrolase activity

TMEM86B TMEM86A

7.18e-062542GO:0047408
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR8H2 CYSLTR2 OR5AC1 GALR3 GPR35 OR6C4 GPR37L1 OR10A6 CHRM2 OR6K6 GLP2R

2.01e-058845411GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR8H2 CYSLTR2 OR5AC1 NRXN3 GALR3 GPR35 OR6C4 GPR37L1 OR10A6 CHRM2 OR6K6 IL6ST GLP2R

4.84e-0513535413GO:0004888
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC5A11 SLC9A3 SLC17A3 SLC25A10 SLC35C2 SLC5A9

1.43e-04296546GO:0015291
GeneOntologyMolecularFunctionD-glucose:sodium symporter activity

SLC5A11 SLC5A9

1.49e-047542GO:0005412
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC5A11 SLC9A3 KCNU1 SLC17A3 SLC5A9 KCNH3 KCNH5

2.44e-04465547GO:0046873
GeneOntologyMolecularFunctionstructural constituent of postsynaptic actin cytoskeleton

POTEF POTEKP

3.89e-0411542GO:0098973
GeneOntologyMolecularFunctionG protein-coupled peptide receptor activity

CYSLTR2 GALR3 GPR37L1 GLP2R

4.60e-04133544GO:0008528
GeneOntologyMolecularFunctionhydrolase activity, acting on ether bonds

TMEM86B TMEM86A

5.49e-0413542GO:0016801
GeneOntologyMolecularFunctionether hydrolase activity

TMEM86B TMEM86A

5.49e-0413542GO:0016803
GeneOntologyMolecularFunctionpeptide receptor activity

CYSLTR2 GALR3 GPR37L1 GLP2R

5.58e-04140544GO:0001653
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC5A11 SLC9A3 KCNU1 SLC17A3 SLC25A10 SLC5A9 KCNH3 KCNH5

9.21e-04758548GO:0015318
GeneOntologyMolecularFunctioncarbohydrate:monoatomic cation symporter activity

SLC5A11 SLC5A9

9.51e-0417542GO:0005402
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

SLC9A3 KCNU1 KCNH3 KCNH5

1.08e-03167544GO:0015079
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC5A11 SLC9A3 KCNU1 SLC17A3 SLC25A10 SLC35C2 SLC5A9 SVOP KCNH3 KCNH5

1.11e-0311805410GO:0022857
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC5A11 SLC9A3 SLC17A3 SLC5A9

1.18e-03171544GO:0015081
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC5A11 SLC17A3 SLC5A9

1.37e-0381543GO:0015370
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC5A11 SLC9A3 KCNU1 SLC17A3 SLC5A9 KCNH3 KCNH5

1.43e-03627547GO:0022890
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC5A11 SLC9A3 SLC17A3 SLC25A10 SLC35C2 SLC5A9

1.76e-03477546GO:0022804
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC5A11 SLC9A3 KCNU1 SLC17A3 SLC5A9 KCNH3 KCNH5

1.98e-03664547GO:0008324
GeneOntologyMolecularFunctionD-glucose transmembrane transporter activity

SLC5A11 SLC5A9

2.07e-0325542GO:0055056
GeneOntologyMolecularFunctionhexose transmembrane transporter activity

SLC5A11 SLC5A9

2.07e-0325542GO:0015149
GeneOntologyMolecularFunctionprotein kinase A regulatory subunit binding

ARFGEF2 ARFGEF1

2.07e-0325542GO:0034237
GeneOntologyMolecularFunctiontransporter activity

SLC5A11 SLC9A3 KCNU1 SLC17A3 SLC25A10 SLC35C2 SLC5A9 SVOP KCNH3 KCNH5

2.14e-0312895410GO:0005215
GeneOntologyMolecularFunctionmonosaccharide transmembrane transporter activity

SLC5A11 SLC5A9

2.41e-0327542GO:0015145
GeneOntologyMolecularFunctionsugar transmembrane transporter activity

SLC5A11 SLC5A9

2.78e-0329542GO:0051119
GeneOntologyMolecularFunctionstructural constituent of postsynapse

POTEF POTEKP

3.38e-0332542GO:0099186
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC5A11 SLC17A3 SLC5A9

4.10e-03119543GO:0015294
GeneOntologyMolecularFunctionodorant binding

OR8H2 OR5AC1 OR6K6

4.92e-03127543GO:0005549
GeneOntologyMolecularFunctionpotassium channel activity

KCNU1 KCNH3 KCNH5

5.03e-03128543GO:0005267
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC5A11 SLC9A3 KCNU1 SLC17A3 SLC5A9 KCNH3 KCNH5

5.29e-03793547GO:0015075
GeneOntologyMolecularFunctionstructural constituent of synapse

POTEF POTEKP

5.77e-0342542GO:0098918
GeneOntologyMolecularFunctioncarbohydrate transmembrane transporter activity

SLC5A11 SLC5A9

5.77e-0342542GO:0015144
GeneOntologyMolecularFunctionolfactory receptor activity

OR8H2 OR5AC1 OR6C4 OR10A6 OR6K6

6.08e-03431545GO:0004984
GeneOntologyMolecularFunctionantiporter activity

SLC9A3 SLC25A10 SLC35C2

6.19e-03138543GO:0015297
GeneOntologyMolecularFunctionsymporter activity

SLC5A11 SLC17A3 SLC5A9

7.79e-03150543GO:0015293
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC5A11 SLC9A3 SLC17A3 SLC5A9

8.86e-03301544GO:0022853
GeneOntologyMolecularFunctionpeptide hormone binding

GALR3 GLP2R

9.73e-0355542GO:0017046
GeneOntologyMolecularFunctionprotein kinase A binding

ARFGEF2 ARFGEF1

1.08e-0258542GO:0051018
GeneOntologyMolecularFunctiongated channel activity

KCNU1 SLC17A3 KCNH3 KCNH5

1.26e-02334544GO:0022836
GeneOntologyMolecularFunctionenzyme regulator activity

A2M MALT1 NLRP12 ARFGEF2 ARFGEF1 GCKR ITIH2 IL6ST SH3BP4

1.31e-021418549GO:0030234
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

SLC17A3 KCNH3 KCNH5

1.31e-02182543GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

SLC17A3 KCNH3 KCNH5

1.35e-02184543GO:0022832
DomainYhhN

TMEM86B TMEM86A

7.90e-062532PF07947
DomainYhhN

TMEM86B TMEM86A

7.90e-062532IPR012506
Domain7tm_1

OR8H2 CYSLTR2 GALR3 GPR35 OR6C4 GPR37L1 OR10A6 OR3A4P CHRM2 OR6K6

1.74e-056775310PF00001
DomainG_PROTEIN_RECEP_F1_1

OR8H2 CYSLTR2 GALR3 GPR35 OR6C4 GPR37L1 OR10A6 OR3A4P CHRM2 OR6K6

1.93e-056855310PS00237
DomainG_PROTEIN_RECEP_F1_2

OR8H2 CYSLTR2 GALR3 GPR35 OR6C4 GPR37L1 OR10A6 OR3A4P CHRM2 OR6K6

2.08e-056915310PS50262
DomainGPCR_Rhodpsn

OR8H2 CYSLTR2 GALR3 GPR35 OR6C4 GPR37L1 OR10A6 OR3A4P CHRM2 OR6K6

2.11e-056925310IPR000276
DomainRhs_assc_core

TENM4 TENM2

2.37e-053532IPR022385
DomainDUF1981

ARFGEF2 ARFGEF1

4.72e-054532PF09324
DomainDCB_dom

ARFGEF2 ARFGEF1

4.72e-054532IPR032629
DomainTox-GHH_dom

TENM4 TENM2

4.72e-054532IPR028916
DomainTENEURIN_N

TENM4 TENM2

4.72e-054532PS51361
DomainTen_N

TENM4 TENM2

4.72e-054532IPR009471
DomainTox-GHH

TENM4 TENM2

4.72e-054532PF15636
DomainTen_N

TENM4 TENM2

4.72e-054532PF06484
DomainSec7_N

ARFGEF2 ARFGEF1

4.72e-054532IPR032691
DomainDCB

ARFGEF2 ARFGEF1

4.72e-054532PF16213
DomainSec7_N

ARFGEF2 ARFGEF1

4.72e-054532PF12783
DomainSec7_C

ARFGEF2 ARFGEF1

4.72e-054532IPR015403
DomainYD

TENM4 TENM2

7.86e-055532IPR006530
DomainGPCR_Rhodpsn_7TM

OR8H2 CYSLTR2 GALR3 GPR35 OR6C4 GPR37L1 OR10A6 CHRM2 OR6K6

1.01e-04670539IPR017452
DomainPAS_9

KCNH3 KCNH5

3.50e-0410532PF13426
DomainNA_SOLUT_SYMP_1

SLC5A11 SLC5A9

4.27e-0411532PS00456
DomainNA_SOLUT_SYMP_2

SLC5A11 SLC5A9

5.12e-0412532PS00457
DomainSSF

SLC5A11 SLC5A9

5.12e-0412532PF00474
DomainNa/solute_symporter

SLC5A11 SLC5A9

5.12e-0412532IPR001734
DomainNA_SOLUT_SYMP_3

SLC5A11 SLC5A9

5.12e-0412532PS50283
DomainNHL

TENM4 TENM2

6.04e-0413532PS51125
DomainK_chnl_volt-dep_EAG/ELK/ERG

KCNH3 KCNH5

7.03e-0414532IPR003938
DomainSec7

ARFGEF2 ARFGEF1

8.10e-0415532PF01369
DomainSec7_alpha_orthog

ARFGEF2 ARFGEF1

8.10e-0415532IPR023394
Domain-

ARFGEF2 ARFGEF1

8.10e-04155321.10.1000.11
DomainSec7

ARFGEF2 ARFGEF1

9.24e-0416532SM00222
DomainSec7_dom

ARFGEF2 ARFGEF1

9.24e-0416532IPR000904
DomainSEC7

ARFGEF2 ARFGEF1

9.24e-0416532PS50190
DomainCarboxyPept-like_regulatory

TENM4 TENM2

1.05e-0317532IPR008969
DomainPAS-assoc_C

KCNH3 KCNH5

2.10e-0324532IPR000700
DomainPAC

KCNH3 KCNH5

2.46e-0326532SM00086
DomainPAC

KCNH3 KCNH5

2.46e-0326532PS50113
DomainPAC

KCNH3 KCNH5

2.46e-0326532IPR001610
DomainCNMP_BINDING_1

KCNH3 KCNH5

3.71e-0332532PS00888
DomainCNMP_BINDING_2

KCNH3 KCNH5

3.71e-0332532PS00889
DomainPAS

KCNH3 KCNH5

3.71e-0332532SM00091
DomainIon_trans_dom

KCNU1 KCNH3 KCNH5

4.16e-03114533IPR005821
DomainIon_trans

KCNU1 KCNH3 KCNH5

4.16e-03114533PF00520
DomaincNMP

KCNH3 KCNH5

4.18e-0334532SM00100
DomainPAS

KCNH3 KCNH5

4.18e-0334532IPR000014
DomainPAS

KCNH3 KCNH5

4.18e-0334532PS50112
DomaincNMP_binding

KCNH3 KCNH5

4.18e-0334532PF00027
DomaincNMP-bd_dom

KCNH3 KCNH5

4.43e-0335532IPR000595
DomainCNMP_BINDING_3

KCNH3 KCNH5

4.43e-0335532PS50042
DomainOlfact_rcpt

OR8H2 OR6C4 OR10A6 OR3A4P OR6K6

5.04e-03393535IPR000725
DomaincNMP-bd-like

KCNH3 KCNH5

5.20e-0338532IPR018490
Domain-

TENM4 TENM2

5.47e-03395322.120.10.30
Domain6-blade_b-propeller_TolB-like

TENM4 TENM2

7.55e-0346532IPR011042
Domain-

KCNH3 KCNH5

8.20e-03485322.60.120.10
Pubmed

Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.

ARFGEF2 ARFGEF1

2.46e-06255217360629
Pubmed

Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.

ARFGEF2 ARFGEF1

2.46e-06255210716990
Pubmed

Membrane association of the Arabidopsis ARF exchange factor GNOM involves interaction of conserved domains.

ARFGEF2 ARFGEF1

2.46e-06255218203920
Pubmed

Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.

ARFGEF2 ARFGEF1

2.46e-06255210212200
Pubmed

Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex.

ARFGEF2 ARFGEF1

2.46e-06255223918382
Pubmed

Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.

ARFGEF2 ARFGEF1

2.46e-06255218417613
Pubmed

Identification of genes related to heart failure using global gene expression profiling of human failing myocardium.

GPR35 GPR37L1

2.46e-06255220100464
Pubmed

Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity.

ARFGEF2 ARFGEF1

7.36e-06355219332778
Pubmed

Specific functions of BIG1 and BIG2 in endomembrane organization.

ARFGEF2 ARFGEF1

7.36e-06355220360857
Pubmed

A C-terminal sequence in the guanine nucleotide exchange factor Sec7 mediates Golgi association and interaction with the Rsp5 ubiquitin ligase.

ARFGEF2 ARFGEF1

7.36e-06355218832381
Pubmed

AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors.

ARFGEF2 ARFGEF1

7.36e-06355216866877
Pubmed

Involvement of BIG1 and BIG2 in regulating VEGF expression and angiogenesis.

ARFGEF2 ARFGEF1

7.36e-06355231199673
Pubmed

Distinct functions for Arf guanine nucleotide exchange factors at the Golgi complex: GBF1 and BIGs are required for assembly and maintenance of the Golgi stack and trans-Golgi network, respectively.

ARFGEF2 ARFGEF1

7.36e-06355218003980
Pubmed

Enhancement of β-catenin activity by BIG1 plus BIG2 via Arf activation and cAMP signals.

ARFGEF2 ARFGEF1

7.36e-06355227162341
Pubmed

The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).

ARFGEF2 ARFGEF1

7.36e-06355223386609
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

A2M PHKA2 CTR9 PRKAA1 SLC25A10 ELOVL1 SSR3 SH3BP4

8.01e-0665055838777146
Pubmed

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

SLC5A11 A2M SLC5A9 GCKR GLP2R KCNH5

1.01e-0531355620800603
Pubmed

Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2).

ARFGEF2 ARFGEF1

1.47e-05455212571360
Pubmed

Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues.

TENM4 TENM2

1.47e-05455210225957
Pubmed

Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing.

ARFGEF2 ARFGEF1

1.47e-05455222084092
Pubmed

Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members.

ARFGEF2 ARFGEF1

1.47e-05455211013081
Pubmed

Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans.

DNAH10 GCKR

1.47e-05455224891332
Pubmed

All four members of the Ten-m/Odz family of transmembrane proteins form dimers.

TENM4 TENM2

1.47e-05455212000766
Pubmed

Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506.

ARFGEF2 ARFGEF1

1.47e-05455212606707
Pubmed

The mammalian Odz gene family: homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles.

TENM4 TENM2

5.13e-05755210625539
Pubmed

Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women.

TMEM86A ITIH2

5.13e-05755222116950
Pubmed

The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain.

TENM4 TENM2

5.13e-05755212915301
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

A2M ALCAM ITGA1 ITIH2 IL6ST

5.45e-0525755516335952
Pubmed

Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice.

TENM4 ALCAM ITGA1

5.78e-054755315172686
Pubmed

Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25.

TENM4 TENM2

6.83e-05855210331952
Pubmed

Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series.

SLC17A3 GCKR

6.83e-05855220162743
Pubmed

Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate.

KCNH3 KCNH5

1.10e-041055226503718
Pubmed

The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics.

WASHC4 VPS29

1.10e-041055220923837
Pubmed

Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development.

TENM4 TENM2

1.10e-041055238713721
Pubmed

Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study.

KCTD10 GCKR

1.34e-041155220570916
Pubmed

Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease.

SLC17A3 GCKR

1.34e-041155219890391
Pubmed

Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.

OSTC SLC17A3 ELOVL1 ALCAM ITIH2 VPS29

1.52e-0451055616712791
Pubmed

Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

A2M ALCAM ITIH2

1.98e-047155312754519
Pubmed

Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.

OSTC MALT1 PRKAA1 ARFGEF1

2.05e-0418355431932471
Pubmed

The human olfactory receptor gene family.

OR8H2 OR5AC1 OR6C4 OR10A6 OR3A4P OR6K6

2.09e-0454155614983052
Pubmed

Identification of a novel actin isoform in hepatocellular carcinoma.

POTEF POTEKP

2.54e-041555216824795
Pubmed

BCAP31 drives TNBC development by modulating ligand-independent EGFR trafficking and spontaneous EGFR phosphorylation.

WASHC4 VPS29

3.70e-041855231588230
Pubmed

A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.

TENM4 ALCAM TENM2

4.12e-049155328558017
Pubmed

A crucial role for Arf6 in the response of commissural axons to Slit.

ARFGEF2 ARFGEF1

4.13e-041955230674481
Pubmed

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.

CABLES2 TENM4 GPR37L1 SVOP VPS29

4.50e-0440555538187761
Pubmed

CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma.

CTR9 ITGA1 KCNH5

4.53e-049455337468549
Pubmed

Cbln1 regulates axon growth and guidance in multiple neural regions.

NRXN3 ALCAM

5.56e-042255236395107
Pubmed

Topoisomerase IIβ Selectively Regulates Motor Neuron Identity and Peripheral Connectivity through Hox/Pbx-Dependent Transcriptional Programs.

ALCAM IL6ST

7.20e-042555229379870
Pubmed

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

SLC25A10 ELOVL1 ARFGEF2 ARFGEF1 SSR3 VPS29 SH3BP4

7.28e-0495255738569033
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

OSTC CYSLTR2 NRXN3 GPR35 CHRM2 SVOP

7.98e-0469755628298427
Pubmed

Little skate genome provides insights into genetic programs essential for limb-based locomotion.

SERINC1 ALCAM

8.40e-042755236288084
Pubmed

Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults.

NRXN3 TENM2

8.40e-042755225133637
Pubmed

Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.

OR8H2 OR5AC1

8.40e-042755232061665
Pubmed

SOSTDC1 promotes invasion and liver metastasis in colorectal cancer via interaction with ALCAM/CD166.

ALCAM ITGA1

9.04e-042855232801337
Pubmed

Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.

DNAH10 GCKR

1.04e-033055219936222
Pubmed

Tangential Intrahypothalamic Migration of the Mouse Ventral Premamillary Nucleus and Fgf8 Signaling.

FOXB1 ALCAM

1.11e-033155234095148
Pubmed

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.

OSTC SERINC1 PRKAA1 SSR3 CHRM2

1.15e-0349955522810586
Pubmed

Newly identified loci that influence lipid concentrations and risk of coronary artery disease.

KCTD10 GCKR

1.41e-033555218193043
Pubmed

A probabilistic classifier for olfactory receptor pseudogenes.

OR10A6 OR3A4P

1.41e-033555216939646
Pubmed

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.

A2M POTEF ITIH2

1.53e-0314355322516433
InteractionKCNH4 interactions

ARFGEF2 ARFGEF1 KCNH3 KCNH5

1.64e-0812504int:KCNH4
InteractionUPK2 interactions

ARFGEF2 ARFGEF1 ALCAM ITIH2 IL6ST

2.66e-05142505int:UPK2
Cytoband12q24.11

WASHC4 KCTD10 SVOP

8.65e-063355312q24.11
CytobandEnsembl 112 genes in cytogenetic band chr12q24

DNAH10 KCTD10 SVOP VPS29

1.56e-03415554chr12q24
Cytoband5q11.2

ITGA1 IL6ST

1.80e-03525525q11.2
Cytoband2q21.1

POTEF POTEKP

2.23e-03585522q21.1
GeneFamilySolute carriers

SLC5A11 SLC9A3 SLC17A3 SLC25A10 SLC35C2 SLC5A9

1.86e-04395396752
GeneFamilyAnkyrin repeat domain containing|POTE ankyrin domain containing

POTEF POTEKP

3.48e-0413392685
GeneFamilyPotassium voltage-gated channels

KCNH3 KCNH5

3.36e-0340392274
GeneFamilyOlfactory receptors, family 6

OR6C4 OR6K6

5.41e-0351392153
GeneFamilyG protein-coupled receptors, Class A orphans

GPR35 GPR37L1

1.23e-0278392262
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN3 DNAH10 SVOP TENM2 KCNH5

1.51e-06158555f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN3 DNAH10 SVOP TENM2 KCNH5

1.51e-061585558c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

A2M TENM4 ITGA1 CHRM2 TENM2

3.46e-06187555bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM4 CHRM2 TENM2 KCNH3 KCNH5

4.03e-06193555461919ab422bc9d1fcff7a3a4757c75239041d7e
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM4 CHRM2 TENM2 KCNH3 KCNH5

4.03e-061935550dd810ad900d3e586551622b2c1de39d76fd6a7f
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

A2M TENM4 ITGA1 CHRM2 TENM2

4.45e-061975556d0d68d460243a0259ada93ebda40fa7b3088eeb
ToppCellControl-PLT_5|World / Disease Group and Platelet Clusters

NBEAL1 SVOP TENM2 KCNH5

1.79e-051265544ba753c4e83eb1d41964edfa22135e047f06c481
ToppCellfacs-Liver-Hepatocytes-3m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRP12 SLC17A3 TMEM86B ITIH2

2.63e-0513955482bf5ba69a907fbd9b4e2b2dd1dd27b8c4c75f25
ToppCellfacs-Liver-Hepatocytes-3m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRP12 SLC17A3 TMEM86B ITIH2

2.63e-05139554fc4b39ac9a10cf0acacfebbc4295edf324d930d5
ToppCellfacs-Liver-Hepatocytes-3m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRP12 SLC17A3 TMEM86B ITIH2

2.63e-051395544ddfbc36a0560fb70594627178bff652ab1ea3e9
ToppCellfacs-Liver-Hepatocytes-3m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRP12 SLC17A3 TMEM86B ITIH2

2.63e-05139554fc9ac09c2106e88104a52575832d71d17765eec8
ToppCellTCGA-Bile_Duct|World / Sample_Type by Project: Shred V9

TMEM86B SLC5A9 GCKR ITIH2

2.71e-05140554ca8a0ccbc2f501b759864fe9bb06dc8b44b6b31f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NLRP12 KCNU1 SVOP KCNH5

5.39e-051675543edb0570e583bb527165bcd8a4c25a042054043b
ToppCellhuman_hepatoblastoma-Tumor_cells-T6|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

MALT1 CYSLTR2 NRXN3 ALCAM

7.05e-0517955414fc8ccb6b215063d747643f47d780d2b237eb67
ToppCelldroplet-Heart-4Chambers-18m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A2M NRXN3 SLC5A9 IL6ST

7.68e-051835546c4a09c02e30e1f24dde39f8cb8c5b453826ee2e
ToppCellControl-Neu_4|World / 5 Neutrophil clusters in COVID-19 patients

DNAH10 NBEAL1 ARFGEF2 ALCAM

7.85e-05184554ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

NRXN3 SLC5A9 CHRM2 KCNH5

8.35e-051875548e8f1f2a78ac5f13a414fd448af7d7ff1ea86f0f
ToppCellRA-10._Endothelium_II|World / Chamber and Cluster_Paper

NRXN3 SLC17A3 ITGA1 IL6ST

8.70e-0518955475c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTR9 ALCAM TMEM86A ITIH2

9.06e-05191554b94e66ac71e73f46b0323d424e7b8b906751d584
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

A2M NRXN3 NBEAL1 ITGA1

9.06e-0519155404c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

NRXN3 CHRM2 SVOP TENM2

9.06e-051915545d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCellEntopeduncular-Neuronal-Inhibitory|Entopeduncular / BrainAtlas - Mouse McCarroll V32

NRXN3 CHRM2 SVOP TENM2

9.06e-0519155473dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCellEntopeduncular-Neuronal|Entopeduncular / BrainAtlas - Mouse McCarroll V32

NRXN3 CHRM2 SVOP TENM2

9.25e-051925544c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCellhuman_hepatoblastoma-Tumor_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

NRXN3 POTEF ARFGEF2 SH3BP4

9.43e-05193554503a979328c68b096680b71359a26f02fafdff35
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN3 TENM4 SVOP KCNH3

9.43e-05193554be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN3 TENM4 SVOP KCNH3

9.43e-051935540c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN3 TENM4 SVOP KCNH3

9.43e-051935548689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellRV-10._Endothelium_II|World / Chamber and Cluster_Paper

NRXN3 SLC17A3 ITGA1 IL6ST

9.43e-051935542531266bc57339d4e2b22a88817008e32b8c1598
ToppCelldroplet-Mammary_Gland-nan-3m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN3 ALCAM TMEM86A ITIH2

9.62e-05194554715e02e5f3250b1bfdc26b7dfd656ba4e705ea84
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLC9A3 TENM4 CHRM2 TENM2

9.82e-05195554f5e91ce20a7ce528dc4c1a968c7bf096bf45c528
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-myocytic|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NRXN3 ALCAM ITGA1 CHRM2

9.82e-0519555426a3a5daf389606ef1ebb35533f12e60853b3a12
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM4 SVOP TENM2 KCNH3

9.82e-05195554ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TENM4 ALCAM ITGA1 IL6ST

1.02e-041975546668f0da54f3bf96769275e668cd57e00b8a5ef9
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TENM4 ALCAM ITGA1 IL6ST

1.02e-041975547c275a2ac24a9a4f83fceda93a067e754837102f
ToppCellIPF|World / Disease state, Lineage and Cell class

A2M OSTC ALCAM VPS29

1.04e-041985547f8734729194caccab8ec98e6c1a00ff5c3655af
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC9A3 GPR35 TMEM86B SLC5A9

1.06e-04199554f26c20f5d7470e90eaa79613d0b87bd4865585a8
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-3|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

A2M TENM4 ITGA1 CHRM2

1.08e-0420055407641f476cb1a131c2a50258b88cc13bb38c8379
ToppCellParenchyma_Control_(B.)-Stromal-TX-Fibroblasts-3|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

A2M TENM4 ITGA1 CHRM2

1.08e-04200554343fa6ba1f52d816d2e41466f674ff8360aecd81
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-3-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

A2M TENM4 ITGA1 CHRM2

1.08e-04200554d0c00cdd52c2e001aec9b935f4e981ba77d0386a
ToppCellStriatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Chat-Inhibitory_Neuron.Gad1Gad2-Chat-Slc17a8.Chat_(cholinergic_interneuron)|Striatum / BrainAtlas - Mouse McCarroll V32

NLRP12 SLC5A9 GCKR

1.14e-04765533073a8ace46ad18bddd22ec8f3a1b59ee2fd989d
ToppCellStriatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Chat-Inhibitory_Neuron.Gad1Gad2-Chat-Slc17a8.Chat_(cholinergic_interneuron)-|Striatum / BrainAtlas - Mouse McCarroll V32

NLRP12 SLC5A9 GCKR

1.14e-04765533f5865b9cb6648b88eb873018e513c5efb457ae5
ToppCellStriatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Chat|Striatum / BrainAtlas - Mouse McCarroll V32

NLRP12 SLC5A9 GCKR

1.14e-0476553041a8984b3ae4bb03ae6db8234c1333ac73098fa
ToppCellStriatum-Neuronal-Inhibitory-iN2(Gad1Gad2)|Striatum / BrainAtlas - Mouse McCarroll V32

NLRP12 SLC5A9 GCKR

1.54e-04845539417fffe0ba79f5851920258dcd0f6c09218be13
Diseasetyrosine-protein phosphatase non-receptor type 7 measurement

NLRP12 GPR37L1

3.05e-062522EFO_0802173
DiseaseAP-4 complex subunit mu-1 measurement

NLRP12 ITIH2

3.04e-055522EFO_0801385
Diseaseannexin A2 measurement

FOXB1 NLRP12

6.36e-057522EFO_0008027
Diseasemannose measurement

SLC5A9 GCKR

8.47e-058522EFO_0006958
Diseasesialic acid-binding Ig-like lectin 12 measurement

NLRP12 GCKR

8.47e-058522EFO_0802066
Diseaseovarian reserve

TMEM86A ITIH2

1.99e-0412522EFO_0004770
Diseasetriglyceride measurement, body mass index

DNAH10 GCKR

5.11e-0419522EFO_0004340, EFO_0004530
Diseasetriglyceride measurement, body fat percentage

KCNU1 DNAH10

6.26e-0421522EFO_0004530, EFO_0007800
Diseasetaurine measurement

NLRP12 TENM4

9.64e-0426522EFO_0010536
DiseaseL lactate dehydrogenase measurement

TENM4 GCKR

9.64e-0426522EFO_0004808
DiseaseDrug habituation

NRXN3 CHRM2 TENM2

1.11e-03115523C0013170
DiseaseDrug abuse

NRXN3 CHRM2 TENM2

1.11e-03115523C0013146
DiseasePrescription Drug Abuse

NRXN3 CHRM2 TENM2

1.11e-03115523C4316881
DiseaseSubstance-Related Disorders

NRXN3 CHRM2 TENM2

1.11e-03115523C0236969
DiseaseDrug Use Disorders

NRXN3 CHRM2 TENM2

1.11e-03115523C0013222
DiseaseDrug Dependence

NRXN3 CHRM2 TENM2

1.11e-03115523C1510472
DiseaseSubstance Dependence

NRXN3 CHRM2 TENM2

1.11e-03115523C0038580
DiseaseSubstance Use Disorders

NRXN3 CHRM2 TENM2

1.11e-03115523C0038586
DiseaseOrganic Mental Disorders, Substance-Induced

NRXN3 CHRM2 TENM2

1.11e-03115523C0029231
DiseaseSubstance abuse problem

NRXN3 CHRM2 TENM2

1.14e-03116523C0740858
Diseasevery low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

DNAH10 KCTD10 GCKR ITGA1

1.21e-03264524EFO_0008317, EFO_0020944

Protein segments in the cluster

PeptideGeneStartEntry
ALYYTTMQTLTKQDT

KCTD10

41

Q9H3F6
AMYVAIQAVLSLYTS

POTEKP

131

Q9BYX7
ADTAYVLAYSIIMLT

ARFGEF1

821

Q9Y6D6
ADTAYVLAYSIIMLT

ARFGEF2

766

Q9Y6D5
IIGVFSMNLYTLYTV

CHRM2

71

P08172
QMTYSLTRFAIYETV

SLC25A10

71

Q9UBX3
VEMTSYVLLAYLTAQ

A2M

1206

P01023
GTCSYINYVITMTTL

NBEAL1

111

Q6ZS30
MTVYALVVVSYFLIT

OSTC

31

Q9NRP0
RYSQYSAVVLTLLMA

KCNH3

351

Q9ULD8
AMYVAIQAVLSLYTS

POTEF

831

A5A3E0
TLMVSLFTISASYVF

OR8H2

206

Q8N162
LVSTMVVYIPTYISS

SLC17A3

231

O00476
TLYSYKVQSTITSRM

ITIH2

71

P19823
AEFSNVMIIYTSIVY

MALT1

606

Q9UDY8
DSLYVSSLYFTMTSL

KCNH5

416

Q8NCM2
YLAICQSLTYSSRMS

OR3A4P

126

P47883
ILTTTGYTQEDYTML

NRXN3

361

Q9Y4C0
ISYFESIYLVMATTS

KCNU1

261

A8MYU2
YLMENVTIYLSATSD

ITGA1

911

P56199
MVTLVLVTLSYTYII

OR6C4

206

Q8NGE1
YLTNRYMSISLVTAI

GPR35

96

Q9HC97
YSYISLTAMAIQSSP

FOXB1

16

Q99853
YQRLYSESILTTMVQ

GCKR

71

Q14397
IQVFTFMTLIVSYSY

OR5AC1

206

P0C628
FMTLIVSYSYILSAI

OR5AC1

211

P0C628
LIYLTMYASSFTLAA

GALR3

101

O60755
EYTLSSLTSDTLYMV

IL6ST

576

P40189
STLQLMYTVGYSFSL

GLP2R

176

O95838
SSYSAYAIMLLALVV

GPR37L1

126

O60883
SVTTSYNLARLYEAM

CTR9

496

Q6PD62
MTSILLTYVYFVLSL

ELOVL1

31

Q9BW60
TDRIYLTLTQALSMY

DNAH10

1811

Q8IVF4
TQLYTMTSTLEYKTT

ALCAM

196

Q13740
VLIFASYMTTVIEYV

CABLES2

321

Q9BTV7
TMTYLTRAVASYLQE

PHKA2

1211

P46019
TSVTLFYGTASMTYL

OR10A6

246

Q8NH74
LVTALYSLYMFTTTQ

MT-ND4

401

P03905
SVAVMYLRFSATYSV

OR6K6

281

Q8NGW6
VMLESSVYLTLAVYS

SVOP

481

Q8N4V2
LTYIYASVRTLLMEN

SH3BP4

751

Q9P0V3
FIISYLSYLTSEMLS

SLC9A3

291

P48764
QVYMSVLSLILYIFT

SLC5A9

151

Q2M3M2
YLYFSMILSTVTLIT

SLC5A11

521

Q8WWX8
YYDINQIITTAVMTL

TENM2

2136

Q9NT68
LLQSSVITVYTMYLT

SERINC1

261

Q9NRX5
LYSVMTLVSTYLVAF

SSR3

61

Q9UNL2
VTSTYSKMSLQLYQV

PRKAA1

451

Q13131
NMYSSIYFLTVLSVV

CYSLTR2

121

Q9NS75
STYYVAQMLVALSAV

TMEM86A

211

Q8N2M4
LYVTVSLYTMTKSSA

SLC35C2

106

Q9NQQ7
IYYDINQIITTAVMT

TENM4

2126

Q6N022
VIMTTYYAAQLLITL

TMEM86B

201

Q8N661
QVLSTVLSMYVVYST

PIGN

656

O95427
VLSMYVVYSTQSSLL

PIGN

661

O95427
VLMDIQASTVVTYVY

VPS29

151

Q9UBQ0
YAYSISTIIKTTMNL

WASHC4

446

Q2M389
QTSRTTTAVYMLYLL

NLRP12

426

P59046