Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionguanylate cyclase activity

GUCY1A2 GUCY1B1

1.92e-0410422GO:0004383
GeneOntologyMolecularFunctionphosphatidylinositol transfer activity

PITPNM1 PITPNM3

2.35e-0411422GO:0008526
GeneOntologyBiologicalProcessdetection of external stimulus

PITPNM1 PCDH15 ANO1 GRK4 EPHB1

2.59e-05173425GO:0009581
GeneOntologyBiologicalProcessdetection of abiotic stimulus

PITPNM1 PCDH15 ANO1 GRK4 EPHB1

2.74e-05175425GO:0009582
GeneOntologyBiologicalProcesssensory perception of temperature stimulus

ANO1 BTBD9 EPHB1

6.30e-0538423GO:0050951
GeneOntologyCellularComponentguanylate cyclase complex, soluble

GUCY1A2 GUCY1B1

2.47e-054432GO:0008074
DomainHNOB

GUCY1A2 GUCY1B1

2.81e-054412PF07700
DomainLNS2

PITPNM1 PITPNM3

7.01e-056412PF08235
DomainLNS2

PITPNM1 PITPNM3

7.01e-056412IPR013209
DomainPI_transfer

PITPNM1 PITPNM3

7.01e-056412IPR001666
DomainLNS2

PITPNM1 PITPNM3

7.01e-056412SM00775
DomainHNOB_dom_associated

GUCY1A2 GUCY1B1

7.01e-056412IPR011645
DomainDDHD

PITPNM1 PITPNM3

7.01e-056412PF02862
DomainDDHD

PITPNM1 PITPNM3

7.01e-056412PS51043
DomainLNS2/PITP

PITPNM1 PITPNM3

7.01e-056412IPR031315
DomainHNOBA

GUCY1A2 GUCY1B1

7.01e-056412PF07701
DomainDDHD_dom

PITPNM1 PITPNM3

7.01e-056412IPR004177
DomainDDHD

PITPNM1 PITPNM3

7.01e-056412SM01127
DomainNO_sig/Golgi_transp_ligand-bd

GUCY1A2 GUCY1B1

1.31e-048412IPR024096
DomainHeme_NO-bd

GUCY1A2 GUCY1B1

1.68e-049412IPR011644
DomainIBR

CUL9 RNF19A

4.21e-0414412SM00647
DomainIBR

CUL9 RNF19A

4.21e-0414412PF01485
DomainIBR_dom

CUL9 RNF19A

4.85e-0415412IPR002867
Domain-

CUL9 BTBD9 EPHB1

5.49e-04734132.60.120.260
DomainA/G_cyclase_CS

GUCY1A2 GUCY1B1

6.26e-0417412IPR018297
DomainNucleotide_cyclase

GUCY1A2 GUCY1B1

7.04e-0418412IPR029787
Domain-

GUCY1A2 GUCY1B1

7.04e-04184123.30.70.1230
DomainGUANYLATE_CYCLASE_1

GUCY1A2 GUCY1B1

7.85e-0419412PS00452
DomainGuanylate_cyc

GUCY1A2 GUCY1B1

7.85e-0419412PF00211
DomainGUANYLATE_CYCLASE_2

GUCY1A2 GUCY1B1

7.85e-0419412PS50125
DomainA/G_cyclase

GUCY1A2 GUCY1B1

7.85e-0419412IPR001054
DomainCYCc

GUCY1A2 GUCY1B1

7.85e-0419412SM00044
DomainGalactose-bd-like

CUL9 BTBD9 EPHB1

1.15e-0394413IPR008979
DomainSUGAR_TRANSPORT_1

SLC2A12 SLC22A5

1.26e-0324412PS00216
DomainSugar_transporter_CS

SLC2A12 SLC22A5

2.24e-0332412IPR005829
DomainMFS_sugar_transport-like

SLC2A12 SLC22A5

2.83e-0336412IPR005828
DomainSugar_tr

SLC2A12 SLC22A5

2.83e-0336412PF00083
DomainMFS_dom

OCLN SLC2A12 SLC22A5

3.15e-03134413IPR020846
Domain-

PITPNM1 PITPNM3

8.70e-03644123.40.50.1000
PathwayREACTOME_SYNTHESIS_OF_PI

PITPNM1 PITPNM3

7.42e-055392MM14587
PathwayREACTOME_SYNTHESIS_OF_PI

PITPNM1 PITPNM3

7.42e-055392M26962
PathwayWP_NOCGMPPKG_MEDIATED_NEUROPROTECTION

GRIN2C GUCY1A2 GUCY1B1

2.92e-0447393M39531
Pubmed

Structural and functional insights into the heme-binding domain of the human soluble guanylate cyclase α2 subunit and heterodimeric α2β1.

GUCY1A2 GUCY1B1

1.49e-06243222426988
Pubmed

BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP phosphorylation.

BLK TOLLIP

1.49e-06243238078859
Pubmed

Chromosomal localization, genomic organization and evolution of the genes encoding human phosphatidylinositol transfer protein membrane-associated (PITPNM) 1, 2 and 3.

PITPNM1 PITPNM3

4.48e-06343215627748
Pubmed

Pitpnm1 is expressed in hair cells during development but is not required for hearing.

PITPNM1 PITPNM3

4.48e-06343223820044
Pubmed

Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation.

GUCY1A2 GUCY1B1

4.48e-06343217610859
Pubmed

Specific variants in WDR35 cause a distinctive form of Ellis-van Creveld syndrome by disrupting the recruitment of the EvC complex and SMO into the cilium.

WDR35 DYNC2H1

4.48e-06343225908617
Pubmed

Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein.

PITPNM1 PITPNM3

8.94e-06443210022914
Pubmed

Partial inversion of gene order within a homologous segment on the X chromosome.

CYBB MAOA

8.94e-0644328431636
Pubmed

TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells.

PCDH15 SLC26A5

1.49e-05543225467981
Pubmed

Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes.

GUCY1A2 GUCY1B1

2.23e-05643219345227
Pubmed

Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes.

GUCY1A2 GUCY1B1

2.23e-05643211572861
Pubmed

Characterization and mapping of the mouse NDP (Norrie disease) locus (Ndp).

CYBB MAOA

3.12e-0574328835523
Pubmed

Localization of monoamine oxidase A and B genes on the mouse X chromosome.

CYBB MAOA

3.12e-0574322573045
Pubmed

Ellis-van Creveld Syndrome

WDR35 DYNC2H1

5.35e-05943237903214
Pubmed

HIV-1 protein Tat produces biphasic changes in NMDA-evoked increases in intracellular Ca2+ concentration via activation of Src kinase and nitric oxide signaling pathways.

GUCY1A2 GUCY1B1

5.35e-05943224666322
Pubmed

Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea.

PCDH15 SLC26A5

5.35e-05943219339464
Pubmed

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.

CYBB GBP1

1.55e-041543225774716
Pubmed

An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studies.

GRIN2C GUCY1A2 ADAMTS6

1.56e-048443315123239
Pubmed

A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection.

CYBB GBP1

2.52e-041943221551061
Pubmed

The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord.

GUCY1A2 GUCY1B1

3.72e-042343217954614
Pubmed

A common variant in DRD3 receptor is associated with autism spectrum disorder.

ATP6V0C MAOA INPP1

5.40e-0412843319058789
Pubmed

Genetic link between renal birth defects and congenital heart disease.

ADAMTS6 DYNC2H1

5.53e-042843227002738
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

CUL9 MCM5 ATP6V0C SDCBP

6.02e-0431343438270169
CytobandEnsembl 112 genes in cytogenetic band chr11q22

GUCY1A2 DYNC2H1

4.57e-03107432chr11q22
GeneFamilyGuanylate cyclases, soluble

GUCY1A2 GUCY1B1

1.93e-054332820
GeneFamilyPhosphatidylinositol transfer proteins

PITPNM1 PITPNM3

4.82e-0563321151
GeneFamilyOlfactory receptors, family 1

OR1Q1 OR1S2

2.41e-0340332147
ToppCellTracheal-10x3prime_v2-Immune_Lymphocytic-B-B_cell-B_mature|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CYBB BLK ADGRG5 ADAMTS6 PKHD1L1

1.25e-061964354b9eb163b9dbbf5eebb160f6554f6f28cb234d31
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-Myeloid-pDC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CYBB BLK ADGRG5 EPHB1

2.27e-051724343aed10e6db48254f4cae12fbe52d1a1fc6cf2dce
ToppCellfacs-Heart-LV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 SYT5 GUCY1A2 GUCY1B1

2.32e-05173434d78397e65e997ddb995111a810f0e2a4f67d0765
ToppCellfacs-Heart-LV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 SYT5 GUCY1A2 GUCY1B1

2.32e-051734343c852ffe22f4a5b632463086b08c669310684e80
ToppCelldroplet-Heart-nan-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 SYT5 GUCY1A2 GUCY1B1

2.53e-05177434dbdbdc8ed9ef0b529694242ef9f9f07a42e16005
ToppCelldroplet-Heart-nan-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 SYT5 GUCY1A2 GUCY1B1

2.59e-05178434416f85e51f45ec7949451fd47611a84e33e87245
ToppCell3'-GW_trimst-1-SmallIntestine-Hematopoietic-Myeloid-pDC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CYBB BLK ADGRG5 EPHB1

2.59e-05178434b7d1d8f76c1c2467b1a39a9b4150ed4a47144a15
ToppCelldroplet-Liver-LIVER_HEP-30m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BLK PCDH15 PITPNM3 PKHD1L1

2.65e-051794344135f9e8cd8494cbc189e5210dded84659643fb8
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 SYT5 GUCY1A2 GUCY1B1

2.65e-05179434bfc226bcf0b93525992344f968268a261d86fcbf
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 SYT5 GUCY1A2 GUCY1B1

2.65e-0517943436ad18f52e175ab636ceaa3be81212fa362c96c1
ToppCellmoderate-Myeloid-pDC|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CYBB BLK ADGRG5 EPHB1

2.71e-05180434a0751ad5e42a21cb107d900abfa9ee967a0069fc
ToppCellfacs-Heart-RV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 PITPNM3 SYT5 GUCY1B1

2.71e-051804340059e5acade6c895fd629767bea1c15f40b0d1b0
ToppCellNS-moderate-d_16-33-Myeloid-pDC|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CYBB BLK ADGRG5 EPHB1

2.71e-05180434144818e69613296cde43f29cb8c20899c670b319
ToppCellfacs-Heart-RV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 PITPNM3 SYT5 GUCY1B1

2.71e-05180434dfb8412e1e06fa7349e66eea2ef27d9ea98b7893
ToppCelldroplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 SYT5 GUCY1A2 GUCY1B1

2.71e-0518043478fdcfb3fdbf36469cae78407cda5bd0996930d8
ToppCell15-Trachea-Immune-Hematopoietic,_B_Cells|Trachea / Age, Tissue, Lineage and Cell class

CYBB BLK ADGRG5 PKHD1L1

2.83e-051824341424d990598d37b22fa44df032be97c1cd1363d1
ToppCellfacs-Heart-RA-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 SYT5 GUCY1A2 GUCY1B1

2.89e-051834340f02136359787bd78146617990968baa47a65d86
ToppCellfacs-Heart-RA-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 SYT5 GUCY1A2 GUCY1B1

2.89e-051834342f0dcc65ad4d90ef946919b4462280fdd20c5ea0
ToppCelldroplet-Lung-30m-Mesenchymal-myofibroblast|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ANO1 SYT5 GUCY1A2 GUCY1B1

2.95e-0518443455dde9c4eebac2a33788c1ff1d8fe312d150fad4
ToppCelldroplet-Lung-30m-Mesenchymal-myofibroblast-pericyte_cell-pericyte|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ANO1 SYT5 GUCY1A2 GUCY1B1

2.95e-051844347128a2be291544d3df3ed6c80f21ddda8437dcba
ToppCelldroplet-Lung-30m-Mesenchymal-myofibroblast-pericyte_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ANO1 SYT5 GUCY1A2 GUCY1B1

2.95e-05184434d14238f7b0b55a4c8d7040bea854bd221a66ac30
ToppCelldroplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 SYT5 GUCY1A2 GUCY1B1

2.95e-05184434f4344f3c407b2d4d703fe56e43d84dbfe60ba833
ToppCellmoderate-Lymphoid-B_cell|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

BLK ADGRG5 MCM5 ADAMTS6

3.08e-05186434fd2c4c3e8929ca5d64f6c5064e5f3d3d6ba07b5f
ToppCelldroplet-Heart-4Chambers-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 PITPNM3 SYT5 GUCY1B1

3.14e-05187434dba4924d914a7dcd4901142684ba920c2404860b
ToppCelldroplet-Heart-4Chambers-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 PITPNM3 SYT5 GUCY1B1

3.14e-051874349688141beef4f62613d7a810c5872ccb9afc1a71
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

PCDH15 ANO1 GBP1 ADAMTS6

3.21e-0518843474f7d216209cabdc96b2d46685b0ae017fdcc8fc
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 SYT5 GUCY1A2 GUCY1B1

3.27e-05189434de51fbd6fdb24fc4549393cf41a020005444b2aa
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 SYT5 GUCY1A2 GUCY1B1

3.34e-051904341d8e169d2448a34180c415843bb49aa45ed540c5
ToppCellfacs-Heart-RA-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 SYT5 GUCY1A2 GUCY1B1

3.34e-05190434bfbdf16d488359d7935a419c4c1823288f39c183
ToppCellfacs-Heart-RA-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 SYT5 GUCY1A2 GUCY1B1

3.34e-05190434eb1f8bb4d903b08e50c2dc173b06c0c79d8e316e
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYBB GBP1 ATP6V0C SDCBP

3.41e-05191434bd0f8adfb2a508babee73477d0e9300330471e7a
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 GUCY1A2 GUCY1B1 GPA33

3.41e-0519143460bc1f3efa7bbad5cb7944fe5e049ea79cd1745a
ToppCellTracheal-10x3prime_v2-Immune_Lymphocytic-B-B_cell|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CYBB BLK ADGRG5 PKHD1L1

3.77e-05196434f37ffb916480281e5905733ac304102dd2e0c05f
ToppCellControl_saline-Hematopoietic_Myeloid-Dendritic_cells-pDC|Control_saline / Treatment groups by lineage, cell group, cell type

CYBB BLK ADGRG5 EPHB1

4.00e-0519943434b95e27581bb127e0b921e9c068dc094cb86b37
ToppCellsevere-Neutrophil|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

GBP1 MGAM SDCBP EPHB1

4.08e-05200434f04d5951bac4dee47c22aaf7973312ca797f322e
ToppCellControl_saline-Hematopoietic_Myeloid-Dendritic_cells|Control_saline / Treatment groups by lineage, cell group, cell type

CYBB BLK ADGRG5 EPHB1

4.08e-052004341559844b3116d41a69081e4ee89e64744a760181
ToppCellSubstantia_nigra-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6_(Thalamus,_glutamatergic)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ADGRG5 MGAM ATP6V0C

5.03e-0574433ef4c9eafc794c7d50aef28b37d21b52d3c511499
ToppCellSubstantia_nigra-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6_(Thalamus,_glutamatergic)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ADGRG5 MGAM ATP6V0C

5.03e-05744336ecbdf4186039a031410e09ecd5afa66b6d5e2dc
ToppCellLPS-antiTNF-Myeloid-Dendritic_cells-pDC|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BLK ADGRG5 EPHB1

2.61e-04129433454bae525f6db3d0dd6347d2a2c3ea9dda9cd212
ToppCellCOVID-19_Moderate-B_cell|World / disease group, cell group and cell class

BLK SYT5 SERPIND1

3.25e-04139433b93e1da87d44e55d75e8cc1b87c2970645679c01
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Monocytic|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

MGAM SDCBP EPHB1

3.39e-041414339f26b2a5ccdf8762f16b673e59543b694fbacc10
ToppCellCOVID-19_Moderate-B_cell|COVID-19_Moderate / disease group, cell group and cell class

BLK SYT5 SERPIND1

3.46e-0414243388bb8d9bca66131df4ee7021b88248e146aa7aa6
ToppCellControl-Myeloid-Dendritic_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CYBB BLK ADGRG5

3.53e-04143433bb8d4c335682d1a6798bed0de8bb0603054a4944
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Monocytic-Classical_Monocyte|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

MGAM SDCBP EPHB1

3.53e-041434335d5ba2717126a0d4e4464f3604cb282cb977d5b2
ToppCellControl-Myeloid-Dendritic_cells-pDC|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CYBB BLK ADGRG5

3.68e-04145433bab85a72142b6257f7d424e5301f65b6dcdf745d
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PITPNM3 GRIN2C MAOA

3.91e-041484331186ee0d15244fee74c1d09df3967c1b69f8ddce
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PITPNM1 GBP1 MCM5

3.99e-04149433c773c2b9685ec44a35246180a93456c8765353f5
ToppCellLPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-pDC|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BLK ADGRG5 EPHB1

4.23e-041524330c6dd41142e4ca1e54ca41e05e42ed29fbf0e570
ToppCellfacs-Aorta-Heart-3m-Mesenchymal-valve_cells|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 GUCY1A2 GUCY1B1

4.31e-041534331440f2716fea74e2c3eb2924eba3d63ebd08c997
ToppCellLPS-IL1RA+antiTNF-Myeloid-Dendritic_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BLK ADGRG5 EPHB1

4.31e-04153433c81a88d3f707487c511020d3960a1c41e706c6a0
ToppCelldroplet-Liver-Npc-21m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYBB SYT5 ADAMTS6

4.39e-04154433d883b3e2a65e4375bea1216eb9bbc86c64ee449c
ToppCelltumor_Lymph_Node_/_Brain-B_lymphocytes-Undetermined|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

CUL9 SYT5 GRIN2C

4.39e-04154433e16f200391537aa1002b0079481b94e1fb86b9ad
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BLK ADGRG5 MCM5

4.39e-04154433d0a1ff02a7e91f6923aa85b65094f78e357e377d
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADGRG5 OCLN SLC26A5

4.64e-041574334766f7d545bf2d775390589460677519cb92f4d5
ToppCellsevere_COVID-19-NK_CD56bright|severe_COVID-19 / disease group, cell group and cell class (v2)

PITPNM3 CROT OCLN

4.73e-04158433c2e8d96fc29aa2388b92b4fd81d2726e1f7a053f
ToppCellChildren_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ANO1 GUCY1A2 GUCY1B1

4.73e-0415843384c0a215dabf697ada036c2b9592d0c61b5077de
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CYBB PITPNM3 GRIN2C

4.82e-04159433210ac7fa89514a84f38d9f42254e38fbc2bc5f42
ToppCell390C-Epithelial_cells-Epithelial-A_(AT2)|390C / Donor, Lineage, Cell class and subclass (all cells)

PITPNM3 ATP6V0C OCLN

4.91e-04160433731def6d82814ebac1a400bc7aea5f6da43ec960
ToppCell390C-Epithelial_cells-Epithelial-A_(AT2)-|390C / Donor, Lineage, Cell class and subclass (all cells)

PITPNM3 ATP6V0C OCLN

4.91e-04160433cf27b4ac4d0caa6f9b068dc8ea93472470a01a4d
ToppCellLPS-IL1RA-Myeloid-Dendritic_cells-pDC|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BLK ADGRG5 EPHB1

4.91e-04160433dee756a2dc9725520d439e7273c489c2284015d8
ToppCellBac-SEP-Lymphocyte-B-B_intermediate|Bac-SEP / Disease, Lineage and Cell Type

BLK PKHD1L1 SLC26A5

5.00e-04161433bcd122af09cbb99d1816200d9c367af8b7f36873
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCDH15 GBP1 PKHD1L1

5.09e-04162433bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellnormal_Lymph_Node-Myeloid_cells-Monocytes|Myeloid_cells / Location, Cell class and cell subclass

PITPNM1 CYBB GRIN2C

5.18e-041634337d7f18e5c99be125e95bc180823430291b770d05
ToppCell367C-Myeloid-Dendritic-pDC|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

BLK ADGRG5 EPHB1

5.27e-0416443395b800c78871354c859abaa832d778786ef7bcc0
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CYBB MCM5 ADAMTS6

5.37e-04165433ba68090d79e2243af2bdee0c27a32e65f540f8ac
ToppCell10x5'-Lung-Lymphocytic_B-Naive_B_cells|Lung / Manually curated celltypes from each tissue

BLK SLC2A12 PKHD1L1

5.37e-041654331776e7db80d7cf6b449fa8635a111705a59231b4
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANO1 PKHD1L1 EPHB1

5.56e-04167433c042d6cdddd0e1ddef1e3ac6f4fe23151127b0f2
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GRIN2C PKHD1L1 EPHB1

5.56e-041674337abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BLK ADGRG5 MCM5

5.56e-0416743353e32d6687a07f486141df9f4ab998af4c03a507
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GRIN2C PKHD1L1 EPHB1

5.56e-04167433d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANO1 PKHD1L1 EPHB1

5.56e-04167433351f8de1fbdf742ac74f9099b254d515ab539bb2
ToppCellfacs-Liver-Non-hepatocytes-3m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYBB GBP1 SDCBP

5.75e-041694330f5e737b265ba333275a0cd289dab029a1542075
ToppCell3'-Adult-SmallIntestine-Hematopoietic-B_cells-Cycling_B_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GRIN2C ADAMTS6 SERPIND1

5.75e-04169433203971cceeba150d0e8891c92662545e84c77837
ToppCellInfluenza_Severe-Neutrophil|World / Disease group and Cell class

MGAM SDCBP EPHB1

5.75e-041694336e8e2580e19c96bcf7fa6a6d8c183df65f428396
ToppCellB_cell|World / lung cells shred on cell class, cell subclass, sample id

BLK ADGRG5 EPHB1

5.85e-04170433cec4090ba6a9c934d5f6f9e4aa7823f3713319b7
ToppCellURO-Lymphocyte-B-B_intermediate|URO / Disease, Lineage and Cell Type

BLK ADAMTS6 PKHD1L1

5.85e-04170433e11d1510518cedabeece96d4adbb90999e6326fa
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Myeloid|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYBB ADGRG5 MCM5

5.85e-04170433d582087a983fe20d811d92f0de0458f3cfd71d2b
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Myeloid-macrophage|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYBB ADGRG5 MCM5

5.85e-04170433dfbe7ba11b867a4e10fa915f282a2e5cb2f5fb8c
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial-N_cells_(NTS+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SYT5 GRIN2C FBLL1

5.85e-0417043302f0be0aab8ba2d35a83238609352ef3677511c9
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

BLK ANO1 ADAMTS6

5.95e-04171433a5634b76476b8b2488a706bbab5141f7bd94631f
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Myeloid-new-cluster|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYBB ADGRG5 MCM5

5.95e-04171433d0d92eb5152410c3b4dd4a3f1dc3cca0e18a85fd
ToppCell367C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MCM5 ADAMTS6 MEX3D

5.95e-04171433e3cab55f39879e2bd3e8bda91802181075839bc4
ToppCell367C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

MCM5 ADAMTS6 MEX3D

5.95e-0417143352fdc2a4ec36fb91583b1215362548ceb6740ae1
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PITPNM1 CYBB GBP1

6.06e-041724333f784aed340b50ddbec3f7dc0a5279180d38a2bb
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BLK ADGRG5 CROT

6.06e-041724334bdcf1ae2a1cfba0272c54072e37fb7958904321
ToppCelldroplet-Kidney-nan-3m-Epithelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 GUCY1A2 EPHB1

6.06e-04172433073a503dc922e3e3ac3528e249b0f8b74402110b
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-pDC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BLK ADGRG5 EPHB1

6.06e-04172433b84610f1e5889a655652800c2b3270d264bfe1a9
ToppCellsevere_COVID-19-Neutrophil|severe_COVID-19 / disease group, cell group and cell class (v2)

GBP1 MGAM EPHB1

6.06e-041724338f4bcb9b2bbf8b4333f673d8ad6bb88dfda4792a
ToppCellBAL-Severe-Myeloid-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GBP1 SDCBP EPHB1

6.16e-041734335b76d9cc56bbb29017e64a2d0a3c76c0be003d96
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil-Neu_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GBP1 SDCBP EPHB1

6.16e-04173433bf685025961e79b379f2c35464b6c8ce3e31ace0
ToppCellBAL-Severe-Myeloid-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GBP1 SDCBP EPHB1

6.16e-04173433a6e73a40b0d5356564a594053e772f9d061a5919
ToppCellsevere_influenza-Neutrophil|severe_influenza / disease group, cell group and cell class (v2)

MGAM SDCBP EPHB1

6.16e-04173433615e266419b9f06e964eff73cb466f05451ba0dd
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GBP1 SDCBP EPHB1

6.16e-04173433a8b5370f4c893a20c58e97659f3ac168699693f8
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil-Neu_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GBP1 SDCBP EPHB1

6.16e-041734331edef5aeab626cbf2c09468e77b02cfa2d21ba03
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GBP1 SDCBP EPHB1

6.16e-04173433c37dba3804df7c3151e18e6ae4e0b6e7a92bae97
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PCDH15 MGAM SLC22A5

6.16e-041734338888434641ea554a9b62c436e87920378eef29cd
ToppCellChildren_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

ANO1 GUCY1A2 GUCY1B1

6.16e-041734335416b092321c7d9b63f0418c60f2402a138355bf
ToppCellsevere_influenza-Neutrophil|World / disease group, cell group and cell class (v2)

MGAM SDCBP EPHB1

6.26e-04174433f9f07436b7d3f190800cd85d229f007032f391e1
ToppCell356C-Lymphocytic-NK_cells-NK_cell_E|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

MED13L GUCY1B1 INPP1

6.26e-04174433a79ebb01a5849c314e02594a9c95009dbb03cb8c
ToppCellFetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ANO1 GUCY1A2 GUCY1B1

6.26e-04174433015d3742d3d79a57413a333f00ef2d380a9848dd
ComputationalGenes in the cancer module 445.

MAOA GUCY1A2 GUCY1B1

7.86e-0615293MODULE_445
ComputationalGenes in the cancer module 65.

GUCY1A2 GUCY1B1

3.12e-0410292MODULE_65
Drugnitroxyl

ATP6V0C GRIN2C GUCY1A2 GUCY1B1 RNF19A MEX3D

1.26e-06185436CID000000945
DrugK m2 6

MGAM SLC22A5

3.48e-062432CID000133256
DrugAC1L9MYN

MGAM GUCY1A2 GUCY1B1

5.02e-0618433CID000449297
Drug4-phenylbutylamine

MAOA GUCY1A2 GUCY1B1 EPHB1

1.28e-0576434CID000083242
DrugAC1L2PB2

CROT SLC22A5

2.09e-054432CID000125849
Drugstrontium chromate

MGAM SYT5 GUCY1A2 GUCY1B1

3.64e-0599434CID000024599
DrugProbucol [23288-49-5]; Up 200; 7.8uM; MCF7; HT_HG-U133A

PITPNM1 GBP1 SYT5 MAOA GUCY1B1

3.65e-052004355626_UP
DiseaseShort rib-polydactyly syndrome, Verma-Naumoff type

WDR35 DYNC2H1

1.97e-055422C0432197
DiseaseShort Rib-Polydactyly Syndrome

WDR35 DYNC2H1

1.53e-0413422C0036996
DiseaseSaldino-Noonan Syndrome

WDR35 DYNC2H1

1.78e-0414422C0036069
DiseaseMajewski Syndrome

WDR35 DYNC2H1

1.78e-0414422C0024507
Diseaseresponse to platinum based chemotherapy, magnesium measurement

PCDH15 GUCY1A2

2.05e-0415422EFO_0004647, EFO_0004845
Diseasematrix metalloproteinase 12 measurement

GUCY1A2 DYNC2H1

2.98e-0418422EFO_0010590
DiseaseHearing Loss, Extreme

PCDH15 SLC26A5

3.70e-0420422C0086395
DiseaseComplete Hearing Loss

PCDH15 SLC26A5

3.70e-0420422C0581883
DiseaseDeaf Mutism

PCDH15 SLC26A5

3.70e-0420422C4082305
DiseasePrelingual Deafness

PCDH15 SLC26A5

3.70e-0420422C0011052
DiseaseBilateral Deafness

PCDH15 SLC26A5

3.70e-0420422C3665473
DiseaseDeafness, Acquired

PCDH15 SLC26A5

3.70e-0420422C0751068
DiseaseCiliopathies

PCDH15 WDR35 DYNC2H1

5.21e-04110423C4277690
DiseaseDeafness

PCDH15 SLC26A5

5.81e-0425422C0011053
DiseaseCrohn's disease (is_implicated_in)

OCLN SLC22A5

8.39e-0430422DOID:8778 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
GYMEVVQIPRGSVHI

ADAMTS6

731

Q9UKP5
VFIATIVYIMGVNPT

OCLN

186

Q16625
GLVIPLGVLQAIAMY

SLC2A12

201

Q8TD20
QLEYVGGISMLIVVP

SERPIND1

346

P05546
MTQYGRVIRQPVGRI

MAOA

416

P21397
ARIDGLRPGMVYVVQ

EPHB1

491

P54762
IGVYDIQTGVPLMGV

INPP1

186

P49441
PVAVEVIVGGVRMVY

MED13L

266

Q71F56
VIVGGVRMVYPSAFV

MED13L

271

Q71F56
PSMNVALYVGIAVGV

GPA33

231

Q99795
KVVPGNRVTIMGIYS

MCM5

256

P33992
IGILVVIIRVYHGMN

AQP7P3

206

A6NL99
VTQQYTELIGRPVMV

MGAM

2121

O43451
LNMVPGQSVYGERRV

FBLL1

121

A6NHQ2
IQVRVPYRVVGLVVG

MEX3D

276

Q86XN8
AVNVMVYVGIPIGEG

KDM3B

1566

Q7LBC6
QPMVVVAIVGLYRTG

GBP1

36

P32455
GEVVTGVIGQRMPRY

GUCY1B1

526

Q02153
GVYTQMLIPASIVGI

ANO1

336

Q5XXA6
SMYVVTVVGNGLIIV

OR1S2

46

Q8NGQ3
TIAPGVEMIVGRTYA

PCDH15

566

Q96QU1
YEQLCQRMGVVIVGP

DYNC2H1

1966

Q8NCM8
FGVLLMEVVTYGRVP

BLK

421

P51451
YEVVMLVGAGIGVTP

CYBB

401

P04839
GEYVQQTLQPGMRVR

CUL9

376

Q8IWT3
RVGTVGYMAPEVVNN

GRK4

346

P32298
IVVQLAQPYMIGSIR

BTBD9

471

Q96Q07
YMVAPVTGNDVGIRR

SDCBP

91

O00560
AELYPTVVRNMGVGV

SLC22A5

451

O76082
VGYLRVQGVVVPMVH

CROT

546

Q9UKG9
GRIITVVYTVVTPML

OR1Q1

271

Q15612
SVLAGVVGVRMPRYC

GUCY1A2

621

P33402
VPYVELGGRVLVMAV

SYT5

181

O00445
YTVLAMIAVTQRGVP

SYNRG

356

Q9UMZ2
PFAVISLMIGGVAVR

SLC26A5

136

P58743
VRSPVVHSVLVMGYG

ADGRG5

406

Q8IZF4
LGIGVYPVRMVVRGD

PITPNM1

991

O00562
IIPVVMAGIIAIYGL

ATP6V0C

56

P27449
AAVTVGIGVPIMLAY

RNF19A

431

Q9NV58
VVLMPTVYQQGVGYV

TOLLIP

186

Q9H0E2
PVPGANMVTGRIEYV

PKHD1L1

2446

Q86WI1
RLGVGVYPVKMVVRG

PITPNM3

706

Q9BZ71
NPVLIDTGMYVVGIQ

WDR35

246

Q9P2L0
GYLVQPTMVVIALNR

GRIN2C

351

Q14957