Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	6-phosphofructo-2-kinase activity	PFKFB1 PFKFB3 PFKFB4	2.66e-07	4	82	3	GO:0003873
GeneOntologyMolecularFunction	fructose-2,6-bisphosphate 2-phosphatase activity	PFKFB1 PFKFB3 PFKFB4	6.64e-07	5	82	3	GO:0004331
GeneOntologyMolecularFunction	phosphofructokinase activity	PFKFB1 PFKFB3 PFKFB4	2.31e-06	7	82	3	GO:0008443
GeneOntologyMolecularFunction	sugar-phosphatase activity	PFKFB1 PFKFB3 PFKFB4	7.85e-06	10	82	3	GO:0050308
GeneOntologyMolecularFunction	carbohydrate phosphatase activity	PFKFB1 PFKFB3 PFKFB4	1.08e-05	11	82	3	GO:0019203
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR1 ITPR2	4.98e-05	3	82	2	GO:0005220
GeneOntologyMolecularFunction	carbohydrate kinase activity	PFKFB1 PFKFB3 PFKFB4	8.42e-05	21	82	3	GO:0019200
GeneOntologyMolecularFunction	C-C chemokine receptor activity	CXCR6 CCR5 CCR8	1.11e-04	23	82	3	GO:0016493
GeneOntologyMolecularFunction	C-C chemokine binding	CXCR6 CCR5 CCR8	1.27e-04	24	82	3	GO:0019957
GeneOntologyMolecularFunction	G protein-coupled chemoattractant receptor activity	CXCR6 CCR5 CCR8	1.62e-04	26	82	3	GO:0001637
GeneOntologyMolecularFunction	chemokine receptor activity	CXCR6 CCR5 CCR8	1.62e-04	26	82	3	GO:0004950
GeneOntologyMolecularFunction	chemokine binding	CXCR6 CCR5 CCR8	3.33e-04	33	82	3	GO:0019956
GeneOntologyMolecularFunction	G protein-coupled receptor activity	NPFFR2 UTS2R TAPT1 CXCR6 P2RY11 MC4R GPR141 CCR5 CCR8 LPAR1 ADGRG4	9.52e-04	884	82	11	GO:0004930
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	CCDC88A ABR KALRN MYO9A SRGAP3 SRGAP1 DENND5A ARHGAP8	1.12e-03	507	82	8	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	CCDC88A ABR KALRN MYO9A SRGAP3 SRGAP1 DENND5A ARHGAP8	1.12e-03	507	82	8	GO:0030695
GeneOntologyMolecularFunction	inositol 1,4,5 trisphosphate binding	ITPR1 ITPR2	1.47e-03	14	82	2	GO:0070679
GeneOntologyMolecularFunction	calcium channel activity	CACNA1B CACHD1 ITPR1 ITPR2	1.97e-03	129	82	4	GO:0005262
GeneOntologyBiologicalProcess	fructose 2,6-bisphosphate metabolic process	PFKFB1 PFKFB3 PFKFB4	1.11e-06	6	80	3	GO:0006003
GeneOntologyBiologicalProcess	fructose metabolic process	PFKFB1 PFKFB3 PFKFB4	3.03e-05	16	80	3	GO:0006000
Domain	6Pfruct_kin	PFKFB1 PFKFB3 PFKFB4	3.13e-07	4	81	3	IPR003094
Domain	6Phosfructo_kin	PFKFB1 PFKFB3 PFKFB4	3.13e-07	4	81	3	IPR013079
Domain	6PF2K	PFKFB1 PFKFB3 PFKFB4	3.13e-07	4	81	3	PF01591
Domain	PG/BPGM_mutase_AS	PFKFB1 PFKFB3 PFKFB4	6.48e-06	9	81	3	IPR001345
Domain	RhoGAP	ABR MYO9A SRGAP3 SRGAP1 ARHGAP8	7.22e-06	62	81	5	SM00324
Domain	RhoGAP	ABR MYO9A SRGAP3 SRGAP1 ARHGAP8	7.81e-06	63	81	5	PF00620
Domain	RHOGAP	ABR MYO9A SRGAP3 SRGAP1 ARHGAP8	8.45e-06	64	81	5	PS50238
Domain	RhoGAP_dom	ABR MYO9A SRGAP3 SRGAP1 ARHGAP8	8.45e-06	64	81	5	IPR000198
Domain	-	ABR MYO9A SRGAP3 SRGAP1 ARHGAP8	8.45e-06	64	81	5	1.10.555.10
Domain	PGAM	PFKFB1 PFKFB3 PFKFB4	9.23e-06	10	81	3	SM00855
Domain	PG_MUTASE	PFKFB1 PFKFB3 PFKFB4	9.23e-06	10	81	3	PS00175
Domain	His_Phos_1	PFKFB1 PFKFB3 PFKFB4	1.68e-05	12	81	3	PF00300
Domain	His_Pase_superF_clade-1	PFKFB1 PFKFB3 PFKFB4	1.68e-05	12	81	3	IPR013078
Domain	EamA_dom	SLC35G3 SLC35G5 SLC35G6	2.76e-05	14	81	3	IPR000620
Domain	EamA	SLC35G3 SLC35G5 SLC35G6	2.76e-05	14	81	3	PF00892
Domain	Rho_GTPase_activation_prot	ABR MYO9A SRGAP3 SRGAP1 ARHGAP8	4.00e-05	88	81	5	IPR008936
Domain	Chemokine_rcpt	CXCR6 CCR5 CCR8	4.23e-05	16	81	3	IPR000355
Domain	InsP3_rcpt-bd	ITPR1 ITPR2	5.56e-05	3	81	2	IPR000493
Domain	TRAM1	TRAM1L1 TRAM1	5.56e-05	3	81	2	PF08390
Domain	Translocation_assoc_membrane	TRAM1L1 TRAM1	5.56e-05	3	81	2	IPR016447
Domain	TRAM1	TRAM1L1 TRAM1	5.56e-05	3	81	2	IPR013599
Domain	His_PPase_superfam	PFKFB1 PFKFB3 PFKFB4	8.49e-05	20	81	3	IPR029033
Domain	-	PFKFB1 PFKFB3 PFKFB4	8.49e-05	20	81	3	3.40.50.1240
Domain	CRAL_TRIO	PRUNE2 KALRN ARHGAP8	9.88e-05	21	81	3	PF00650
Domain	ARM-type_fold	KIFAP3 PSME4 TTI1 DAAM2 LRBA ARMH3 ITPR1 ITPR2	1.10e-04	339	81	8	IPR016024
Domain	Tox-GHH_dom	TENM3 TENM1	1.11e-04	4	81	2	IPR028916
Domain	Ten_N	TENM3 TENM1	1.11e-04	4	81	2	IPR009471
Domain	Ten_N	TENM3 TENM1	1.11e-04	4	81	2	PF06484
Domain	TENEURIN_N	TENM3 TENM1	1.11e-04	4	81	2	PS51361
Domain	Tox-GHH	TENM3 TENM1	1.11e-04	4	81	2	PF15636
Domain	-	PRUNE2 KALRN ARHGAP8	1.31e-04	23	81	3	3.40.525.10
Domain	SEC14	PRUNE2 KALRN ARHGAP8	1.69e-04	25	81	3	SM00516
Domain	YD	TENM3 TENM1	1.84e-04	5	81	2	IPR006530
Domain	CRAL_TRIO	PRUNE2 KALRN ARHGAP8	2.13e-04	27	81	3	PS50191
Domain	CRAL-TRIO_dom	PRUNE2 KALRN ARHGAP8	2.38e-04	28	81	3	IPR001251
Domain	RIH_assoc	ITPR1 ITPR2	2.76e-04	6	81	2	PF08454
Domain	RIH_assoc-dom	ITPR1 ITPR2	2.76e-04	6	81	2	IPR013662
Domain	RIH_dom	ITPR1 ITPR2	2.76e-04	6	81	2	IPR000699
Domain	Ins145_P3_rcpt	ITPR1 ITPR2	2.76e-04	6	81	2	IPR014821
Domain	Ryanodine_recept-rel	ITPR1 ITPR2	2.76e-04	6	81	2	IPR015925
Domain	-	ITPR1 ITPR2	2.76e-04	6	81	2	1.25.10.30
Domain	RYDR_ITPR	ITPR1 ITPR2	2.76e-04	6	81	2	PF01365
Domain	Ins145_P3_rec	ITPR1 ITPR2	2.76e-04	6	81	2	PF08709
Domain	MIR	ITPR1 ITPR2	8.17e-04	10	81	2	PS50919
Domain	MIR	ITPR1 ITPR2	8.17e-04	10	81	2	PF02815
Domain	MIR	ITPR1 ITPR2	8.17e-04	10	81	2	SM00472
Domain	MIR_motif	ITPR1 ITPR2	8.17e-04	10	81	2	IPR016093
Domain	CRAL_TRIO_2	PRUNE2 ARHGAP8	1.19e-03	12	81	2	PF13716
Domain	NHL	TENM3 TENM1	1.40e-03	13	81	2	PS51125
Domain	TLC	TRAM1L1 TRAM1	2.14e-03	16	81	2	PS50922
Domain	TLC	TRAM1L1 TRAM1	2.14e-03	16	81	2	SM00724
Domain	TRAM_LAG1_CLN8	TRAM1L1 TRAM1	2.14e-03	16	81	2	PF03798
Domain	TLC-dom	TRAM1L1 TRAM1	2.14e-03	16	81	2	IPR006634
Domain	EGF_extracell	TENM3 TENM1 ITGB5	2.25e-03	60	81	3	IPR013111
Domain	EGF_2	TENM3 TENM1 ITGB5	2.25e-03	60	81	3	PF07974
Domain	GPCR_Rhodpsn_7TM	NPFFR2 UTS2R CXCR6 P2RY11 MC4R GPR141 CCR5 CCR8 LPAR1	2.43e-03	670	81	9	IPR017452
Domain	7tm_1	NPFFR2 UTS2R CXCR6 P2RY11 MC4R GPR141 CCR5 CCR8 LPAR1	2.61e-03	677	81	9	PF00001
Domain	-	KIFAP3 PSME4 TTI1 DAAM2 LRBA	2.79e-03	222	81	5	1.25.10.10
Domain	G_PROTEIN_RECEP_F1_1	NPFFR2 UTS2R CXCR6 P2RY11 MC4R GPR141 CCR5 CCR8 LPAR1	2.82e-03	685	81	9	PS00237
Domain	G_PROTEIN_RECEP_F1_2	NPFFR2 UTS2R CXCR6 P2RY11 MC4R GPR141 CCR5 CCR8 LPAR1	2.99e-03	691	81	9	PS50262
Domain	GPCR_Rhodpsn	NPFFR2 UTS2R CXCR6 P2RY11 MC4R GPR141 CCR5 CCR8 LPAR1	3.02e-03	692	81	9	IPR000276
Domain	FCH	SRGAP3 SRGAP1	4.06e-03	22	81	2	PF00611
Domain	FCH	SRGAP3 SRGAP1	4.06e-03	22	81	2	SM00055
Pathway	REACTOME_SIGNALING_BY_GPCR	NPFFR2 UTS2R ABR KALRN CXCR6 P2RY11 MC4R CCR5 CCR8 ADCY3 LPAR1 ITPR1 ITPR2	7.42e-06	702	61	13	M746
Pathway	REACTOME_REGULATION_OF_GLYCOLYSIS_BY_FRUCTOSE_2_6_BISPHOSPHATE_METABOLISM	PFKFB1 PFKFB3 PFKFB4	1.65e-05	12	61	3	M27950
Pathway	REACTOME_SIGNALING_BY_GPCR	NPFFR2 UTS2R ABR KALRN CXCR6 MC4R CCR5 CCR8 ADCY3 LPAR1 ITPR1 ITPR2	1.71e-05	646	61	12	MM14962
Pathway	REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS	NPFFR2 UTS2R KALRN P2RY11 LPAR1 ITPR1 ITPR2	4.01e-05	217	61	7	M18437
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	NPFFR2 UTS2R CXCR6 P2RY11 MC4R CCR5 CCR8 LPAR1	8.28e-05	330	61	8	M18334
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY	ITPR1 ITPR2	1.83e-04	5	61	2	M49000
Pathway	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS	NPFFR2 UTS2R CXCR6 MC4R CCR5 CCR8	2.02e-04	197	61	6	M12289
Pathway	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS	NPFFR2 UTS2R CXCR6 MC4R CCR5 CCR8	2.02e-04	197	61	6	MM14970
Pathway	WP_GPCRS_PEPTIDE	CXCR6 MC4R CCR5 CCR8	2.35e-04	70	61	4	MM15959
Pathway	KEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2	2.73e-04	6	61	2	M47960
Pathway	REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS	NPFFR2 UTS2R KALRN LPAR1 ITPR1 ITPR2	2.86e-04	210	61	6	MM15043
Pathway	WP_PEPTIDE_GPCRS	CXCR6 MC4R CCR5 CCR8	3.07e-04	75	61	4	M39696
Pathway	REACTOME_RHOA_GTPASE_CYCLE	ABR KALRN MYO9A SRGAP1 ARHGAP8	3.65e-04	142	61	5	MM15576
Pathway	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	CXCR6 CCR5 CCR8 ADCY3 LPAR1 ITPR1 ITPR2	3.96e-04	314	61	7	M600
Pathway	KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM	PFKFB1 PFKFB3 PFKFB4	4.19e-04	34	61	3	M15898
Pathway	REACTOME_RHOA_GTPASE_CYCLE	ABR KALRN MYO9A SRGAP1 ARHGAP8	4.56e-04	149	61	5	M41805
Pathway	REACTOME_INACTIVATION_OF_CDC42_AND_RAC1	SRGAP3 SRGAP1	5.07e-04	8	61	2	M27349
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	NPFFR2 UTS2R CXCR6 MC4R CCR5 CCR8 LPAR1	5.62e-04	333	61	7	MM14963
Pathway	KEGG_GAP_JUNCTION	ADCY3 LPAR1 ITPR1 ITPR2	6.14e-04	90	61	4	M4013
Pathway	KEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2	6.50e-04	9	61	2	M47852
Pathway	REACTOME_DAG_AND_IP3_SIGNALING	ADCY3 ITPR1 ITPR2	7.31e-04	41	61	3	M512
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR2	8.11e-04	10	61	2	M47661
Pathway	REACTOME_GPCR_LIGAND_BINDING	NPFFR2 UTS2R CXCR6 P2RY11 MC4R CCR5 CCR8 LPAR1	8.14e-04	463	61	8	M507
Pathway	REACTOME_CLEC7A_DECTIN_1_SIGNALING	PSME4 PSMD12 ITPR1 ITPR2	9.13e-04	100	61	4	M27467
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR2	9.88e-04	11	61	2	M49033
Pathway	REACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION	ITPR1 ITPR2	9.88e-04	11	61	2	M27466
Pathway	WP_GPCRS_NONODORANT	NPFFR2 UTS2R CXCR6 MC4R CCR8 LPAR1	9.93e-04	266	61	6	MM15843
Pathway	PID_RHOA_REG_PATHWAY	ABR SRGAP1 ARHGAP8	1.03e-03	46	61	3	M68
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	NPFFR2 UTS2R P2RY11 GLRA2 MC4R LPAR1	1.11e-03	272	61	6	M13380
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	PFKFB1 ADCY3 ITPR1 ITPR2	1.22e-03	108	61	4	M17034
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR2	1.39e-03	13	61	2	M47656
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	1.39e-03	13	61	2	M47696
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	1.39e-03	13	61	2	M47751
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	ITPR1 ITPR2	1.39e-03	13	61	2	MM14553
Pathway	KEGG_OOCYTE_MEIOSIS	SPDYC ADCY3 ITPR1 ITPR2	1.44e-03	113	61	4	M16817
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	ADCY3 ITPR1 ITPR2	1.63e-03	54	61	3	M26911
Pathway	WP_FOCAL_ADHESION_PI3KAKTMTORSIGNALING	LAMA2 PFKFB1 PFKFB3 PFKFB4 ITGB5 LPAR1	1.90e-03	302	61	6	M39719
Pathway	REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES	CXCR6 CCR5 CCR8	1.91e-03	57	61	3	M625
Pathway	REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES	CXCR6 CCR5 CCR8	2.01e-03	58	61	3	MM14978
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	ITPR1 ITPR2	2.13e-03	16	61	2	M26945
Pathway	REACTOME_GPCR_LIGAND_BINDING	NPFFR2 UTS2R CXCR6 MC4R CCR5 CCR8 LPAR1	2.47e-03	430	61	7	MM15160
Pathway	REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR	PSME4 PSMD12 ITPR1 ITPR2	2.47e-03	131	61	4	MM15717
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	WASHC4 TAPT1 PIGK VPS13C TENM1 RAI14 ATG9A LRBA SLC27A4 ITPR1 ITPR2	2.94e-08	504	82	11	34432599
Pubmed	Expression of human placental-type 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase in various cells and cell lines.	PFKFB1 PFKFB3 PFKFB4	5.04e-08	4	82	3	9464277
Pubmed	6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme.	PFKFB1 PFKFB3 PFKFB4	5.04e-08	4	82	3	7574501
Pubmed	RT-PCR of fatty acid elongases.	SLC35G3 SLC35G5 SLC35G6	5.04e-08	4	82	3	9056918
Pubmed	Emergence of primate genes by retrotransposon-mediated sequence transduction.	SLC35G3 SLC35G5 SLC35G6	5.04e-08	4	82	3	17101974
Pubmed	Cloning, expression and chromosomal localization of a human testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene.	PFKFB1 PFKFB3 PFKFB4	5.04e-08	4	82	3	10095107
Pubmed	Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase.	PFKFB1 PFKFB3 PFKFB4	5.04e-08	4	82	3	2837207
Pubmed	The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate.	PFKFB1 PFKFB3 PFKFB4	4.39e-07	7	82	3	15896703
Pubmed	Use of alternate coreceptors on primary cells by two HIV-1 isolates.	CXCR6 CCR5 CCR8	4.39e-07	7	82	3	15992849
Pubmed	Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice.	PFKFB1 PFKFB3 PFKFB4	1.05e-06	9	82	3	21074528
Pubmed	Defining the membrane proteome of NK cells.	AMFR SLC11A2 ABR PIGK CNOT10 PSMD12 ATG9A LRBA ADCY3 RUSF1 SLC27A4 ITPR1 ITPR2	3.36e-06	1168	82	13	19946888
Pubmed	CC chemokine receptor 5 and CXC chemokine receptor 6 expression by lung CD8+ cells correlates with chronic obstructive pulmonary disease severity.	CXCR6 CCR5	5.49e-06	2	82	2	17640964
Pubmed	Loss of PFKFB4 induces cell death in mitotically arrested ovarian cancer cells.	PFKFB3 PFKFB4	5.49e-06	2	82	2	28152500
Pubmed	Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta.	PFKFB3 PFKFB4	5.49e-06	2	82	2	8830046
Pubmed	An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown.	ITPR1 ITPR2	5.49e-06	2	82	2	18708078
Pubmed	Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice.	ITPR1 ITPR2	5.49e-06	2	82	2	15201137
Pubmed	Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2.	ITPR1 ITPR2	5.49e-06	2	82	2	23582047
Pubmed	Slit-Robo GTPase-activating proteins are differentially expressed in murine dorsal root ganglia: modulation by peripheral nerve injury.	SRGAP3 SRGAP1	5.49e-06	2	82	2	22271578
Pubmed	Splice isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4: expression and hypoxic regulation.	PFKFB3 PFKFB4	5.49e-06	2	82	2	16311927
Pubmed	Type 1 and 2 IP3 receptors respond differently to catecholamines and stress.	ITPR1 ITPR2	5.49e-06	2	82	2	19120126
Pubmed	Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity.	MC4R ADCY3	5.49e-06	2	82	2	29311635
Pubmed	Short communication: evidence of HIV type 1 clade C env clones containing low V3 loop charge obtained from an AIDS patient in India that uses CXCR6 and CCR8 for entry in addition to CCR5.	CXCR6 CCR5	5.49e-06	2	82	2	20854195
Pubmed	Mutations in LAMA2 and CAPN3 genes associated with genetic and phenotypic heterogeneities within a single consanguineous family involving both congenital and progressive muscular dystrophies.	CAPN3 LAMA2	5.49e-06	2	82	2	20477750
Pubmed	Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.	KALRN SRGAP3 SRGAP1 NCKIPSD	6.09e-06	50	82	4	19807924
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	WASHC4 PSME4 KALRN RAI14 PSMD12 LRBA SNRNP200	7.90e-06	304	82	7	32235678
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PRUNE2 SRD5A3 ABR MYO9A VPS13C RAI14 PFKFB1 DENND5A PFKFB4 LRBA INTS3 ARHGAP8 ITGB5 ADCY3	9.39e-06	1489	82	14	28611215
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	OTULIN OSBPL2 TAPT1 TRAM1 RUSF1 SLC27A4 ITPR1 ITPR2	1.51e-05	468	82	8	31056421
Pubmed	Use of (alternative) coreceptors for HIV entry.	CXCR6 CCR5 CCR8	1.63e-05	21	82	3	22842622
Pubmed	Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.	ITPR1 ITPR2	1.64e-05	3	82	2	10874040
Pubmed	Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.	ITPR1 ITPR2	1.64e-05	3	82	2	9808793
Pubmed	Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo.	PFKFB3 PFKFB4	1.64e-05	3	82	2	14623077
Pubmed	Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.	ITPR1 ITPR2	1.64e-05	3	82	2	20395455
Pubmed	Increased expression and phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoforms in urinary exosomes in pre-eclampsia.	PFKFB3 PFKFB4	1.64e-05	3	82	2	30819197
Pubmed	Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function.	CCR5 CCR8	1.64e-05	3	82	2	10469138
Pubmed	Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.	ITPR1 ITPR2	1.64e-05	3	82	2	17437169
Pubmed	Sustained signalling by PTH modulates IP3 accumulation and IP3 receptors through cyclic AMP junctions.	ADCY3 ITPR1	1.64e-05	3	82	2	25431134
Pubmed	Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.	ITPR1 ITPR2	1.64e-05	3	82	2	18194433
Pubmed	Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.	ITPR1 ITPR2	1.64e-05	3	82	2	18547250
Pubmed	Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.	ITPR1 ITPR2	1.64e-05	3	82	2	36350267
Pubmed	Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability.	ITPR1 ITPR2	1.64e-05	3	82	2	32320395
Pubmed	IP3 receptors regulate vascular smooth muscle contractility and hypertension.	ITPR1 ITPR2	1.64e-05	3	82	2	27777977
Pubmed	The versatility and universality of calcium signalling.	ITPR1 ITPR2	1.64e-05	3	82	2	11413485
Pubmed	Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	1.64e-05	3	82	2	26009177
Pubmed	Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.	ITPR1 ITPR2	1.64e-05	3	82	2	17581770
Pubmed	Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.	ITPR1 ITPR2	1.64e-05	3	82	2	18241669
Pubmed	Receptor-activated single channels in intact human platelets.	ITPR1 ITPR2	1.64e-05	3	82	2	1693919
Pubmed	Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.	ITPR1 ITPR2	1.64e-05	3	82	2	19068129
Pubmed	Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.	ITPR1 ITPR2	1.64e-05	3	82	2	23955339
Pubmed	Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.	ITPR1 ITPR2	1.64e-05	3	82	2	31979185
Pubmed	CCR5, GPR15, and CXCR6 are major coreceptors of human immunodeficiency virus type 2 variants isolated from individuals with and without plasma viremia.	CXCR6 CCR5	1.64e-05	3	82	2	15650194
Pubmed	Mice transgenic for CD4-specific human CD4, CCR5 and cyclin T1 expression: a new model for investigating HIV-1 transmission and treatment efficacy.	CCNT1 CCR5	1.64e-05	3	82	2	23691059
Pubmed	Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.	ITPR1 ITPR2	1.64e-05	3	82	2	24904548
Pubmed	Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	1.64e-05	3	82	2	17327232
Pubmed	Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.	ITPR1 ITPR2	1.64e-05	3	82	2	23223241
Pubmed	Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system.	SRGAP3 SRGAP1	1.64e-05	3	82	2	19137586
Pubmed	Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.	ITPR1 ITPR2	1.64e-05	3	82	2	16014380
Pubmed	Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.	ITPR1 ITPR2	1.64e-05	3	82	2	17890015
Pubmed	Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.	ITPR1 ITPR2	1.64e-05	3	82	2	23983250
Pubmed	Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.	ITPR1 ITPR2	1.64e-05	3	82	2	9858485
Pubmed	Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.	ITPR1 ITPR2	1.64e-05	3	82	2	20427533
Pubmed	Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy.	CXCR6 CCR5	1.64e-05	3	82	2	16470129
Pubmed	Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers.	PFKFB3 PFKFB4	1.64e-05	3	82	2	17143338
Pubmed	Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders.	TENM3 TENM1 LAMA2	1.88e-05	22	82	3	35245678
Pubmed	Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.	ITPR1 ITPR2	3.28e-05	4	82	2	25215520
Pubmed	Linkages between HIV-1 specificity for CCR5 or CXCR4 and in vitro usage of alternative coreceptors during progressive HIV-1 subtype C infection.	CCR5 CCR8	3.28e-05	4	82	2	24041034
Pubmed	Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues.	TENM3 TENM1	3.28e-05	4	82	2	10225957
Pubmed	Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.	ITPR1 ITPR2	3.28e-05	4	82	2	21424589
Pubmed	Polymorphisms in the NPY2R gene show significant associations with BMI that are additive to FTO, MC4R, and NPFFR2 gene effects.	NPFFR2 MC4R	3.28e-05	4	82	2	21818152
Pubmed	[EXPRESSION OF PFKFB, HK2, NAMPT, TSPAN13 AND HSPB8 GENES IN PEDIATRIC GLIOMA].	PFKFB3 PFKFB4	3.28e-05	4	82	2	27491149
Pubmed	Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.	ITPR1 ITPR2	3.28e-05	4	82	2	21818117
Pubmed	Viral entry through CXCR4 is a pathogenic factor and therapeutic target in human immunodeficiency virus type 1 disease.	CXCR6 CCR5	3.28e-05	4	82	2	10590105
Pubmed	Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.	ITPR1 ITPR2	3.28e-05	4	82	2	28615414
Pubmed	Beta1 integrins control the formation of cell chains in the adult rostral migratory stream.	LAMA2 ITGB5	3.28e-05	4	82	2	17344408
Pubmed	Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.	ITPR1 ITPR2	3.28e-05	4	82	2	10828023
Pubmed	IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.	ITPR1 ITPR2	3.28e-05	4	82	2	28419336
Pubmed	All four members of the Ten-m/Odz family of transmembrane proteins form dimers.	TENM3 TENM1	3.28e-05	4	82	2	12000766
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	ITPR1 ITPR2	3.28e-05	4	82	2	19120137
Pubmed	Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	3.28e-05	4	82	2	11163362
Pubmed	IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.	ITPR1 ITPR2	3.28e-05	4	82	2	35494252
Pubmed	T lymphocyte recruitment into renal cell carcinoma tissue: a role for chemokine receptors CXCR3, CXCR6, CCR5, and CCR6.	CXCR6 CCR5	3.28e-05	4	82	2	22079021
Pubmed	Functional impact of HIV coreceptor-binding site mutations.	CCR5 CCR8	3.28e-05	4	82	2	16631222
Pubmed	The chemokine CCL1 facilitates pulmonary fibrosis by promoting macrophage migration and M2 polarization.	AMFR CCR8	3.28e-05	4	82	2	37220693
Pubmed	[EXPRESSION OF GENES, WHICH CONTROL GLUCOSE METABOLISM, IN BLOOD CELLS OF THE OBESE BOYS WITH INSULIN RESISTANCE].	PFKFB1 PFKFB3	3.28e-05	4	82	2	26827442
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	TRAM1L1 TRAM1 CNOT10 NCKIPSD MC4R TTI1 CCR5 CCR8 LPAR1	3.94e-05	697	82	9	28298427
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	CCNT1 TENM3 TTI1 POLR1B RAI14 PSMD12 SCAF4 ITPR1	4.07e-05	538	82	8	10512203
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	CCDC88A ABR MYO9A CCT8 RAI14 CACHD1 PSMD12 LRBA SNRNP200	4.45e-05	708	82	9	39231216
Pubmed	IL-4/CCL22/CCR4 axis controls regulatory T-cell migration that suppresses inflammatory bone loss in murine experimental periodontitis.	CCR5 CCR8	5.47e-05	5	82	2	25264308
Pubmed	HIV-1 infection and chemokine receptor modulation.	CXCR6 CCR8	5.47e-05	5	82	2	15053339
Pubmed	InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.	ITPR1 ITPR2	5.47e-05	5	82	2	21568942
Pubmed	Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells.	CCR5 CCR8	5.47e-05	5	82	2	21217759
Pubmed	Melanocortin 4 receptor signals at the neuronal primary cilium to control food intake and body weight.	MC4R ADCY3	5.47e-05	5	82	2	33938449
Pubmed	BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor.	ITPR1 ITPR2	5.47e-05	5	82	2	11782428
Pubmed	Coreceptor usage of HIV-1 isolates representing different genetic subtypes obtained from pregnant Cameroonian women. European Network for In Utero Transmission of HIV-1.	CXCR6 CCR5	5.47e-05	5	82	2	10877489
Pubmed	Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade.	CXCR6 CCR5	5.47e-05	5	82	2	33357452
Pubmed	Genome-wide association study of smoking behaviours among Bangladeshi adults.	TAPT1 TENM3 ITPR2	7.17e-05	34	82	3	24665060
Pubmed	Stable association between G alpha(q) and phospholipase C beta 1 in living cells.	NPFFR2 UTS2R P2RY11 LPAR1	7.76e-05	95	82	4	16754659
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	ITPR1 ITPR2	8.19e-05	6	82	2	23463619
Pubmed	Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.	ITPR1 ITPR2	8.19e-05	6	82	2	21762810
Pubmed	Increased responsiveness of murine eosinophils to MIP-1beta (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8.	CCR5 CCR8	8.19e-05	6	82	2	12050188
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	ITPR1 ITPR2	8.19e-05	6	82	2	20519450
GeneFamily	6-phosphofructo-2-kinases/fructose-2,6-biphosphatases	PFKFB1 PFKFB3 PFKFB4	1.32e-07	4	59	3	1077
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR1 ITPR2	3.13e-05	3	59	2	297
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	PRUNE2 ARHGAP8	2.18e-04	7	59	2	1299
GeneFamily	TLC domain containing	TRAM1L1 TRAM1	4.63e-04	10	59	2	1374
GeneFamily	CD molecules\|C-C motif chemokine receptors	CCR5 CCR8	4.63e-04	10	59	2	1091
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	SRGAP3 SRGAP1 ARHGAP8	5.80e-04	50	59	3	721
GeneFamily	Solute carriers	SLC11A2 SLC16A3 SLC35G3 SLC35G5 SLC35G6 SLC27A4	1.78e-03	395	59	6	752
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	SRGAP3 SRGAP1	2.53e-03	23	59	2	1288
GeneFamily	Proteasome	PSME4 PSMD12	8.68e-03	43	59	2	690
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN LAMA2 DAAM2 SLC35G6 LPAR1	6.86e-07	168	82	6	d19a115365c5415e51c039718d7669de788fcf33
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN SRGAP1 LAMA2 DENND5A LPAR1	1.41e-06	190	82	6	1121eb607a984c59fbffe7220837fc178745aa55
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN SRGAP1 LAMA2 DENND5A LPAR1	1.41e-06	190	82	6	048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN LAMA2 DAAM2 ADCY3 LPAR1	1.54e-06	193	82	6	c8c21eee8c6c086dc2faf416669cd4a002870fbe
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN LAMA2 DAAM2 ADCY3 LPAR1	1.54e-06	193	82	6	5b602b1702283184bd3943c2a6f2290b7c37e407
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN LAMA2 DAAM2 ADCY3 LPAR1	1.59e-06	194	82	6	e03ba6caed59fa64d4d9b042593469d4a6a3dc10
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN LAMA2 DAAM2 ADCY3 LPAR1	1.63e-06	195	82	6	cad6563cc51d212554152c727fc2c249c6a07e4d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN LAMA2 DAAM2 ADCY3 LPAR1	1.63e-06	195	82	6	edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN LAMA2 DAAM2 ADCY3 LPAR1	1.63e-06	195	82	6	783bfa8110161cbd6def50ce849cae676c39c458
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN LAMA2 DAAM2 ADCY3 LPAR1	1.73e-06	197	82	6	09946ee8dfb15a2a32da06e5b331f3277ee934f4
ToppCell	facs-Brain_Myeloid-Cortex_-18m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC3 AMFR TRAM1 CCR5 LRBA ITGB5	1.73e-06	197	82	6	e73ca8c8f42cbcc56eaa5fe3d69abd1ce7b7bbca
ToppCell	facs-Brain_Myeloid-Cortex_\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC3 AMFR TRAM1 CCR5 LRBA ITGB5	1.73e-06	197	82	6	81379fe6bd14a1ba26f4a159497262adcb600b18
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN LAMA2 DAAM2 ADCY3 LPAR1	1.73e-06	197	82	6	ae0435f4b4a9cdedb1c201fc56921048390097bf
ToppCell	facs-Brain_Myeloid-Cortex_-18m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC3 AMFR TRAM1 CCR5 LRBA ITGB5	1.73e-06	197	82	6	271c75f491d03bd248c7ec037ef02e39456f3ac0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN LAMA2 DAAM2 ADCY3 LPAR1	1.73e-06	197	82	6	37f6b6f2809b952382eaebb642b0aad6371f4251
ToppCell	facs-Brain_Myeloid-Cortex_-18m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC3 AMFR TRAM1 CCR5 LRBA ITGB5	1.73e-06	197	82	6	9db329c6fea532dd1afb624f4c29c92407f45568
ToppCell	facs-Brain_Myeloid-Cortex_-18m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC3 AMFR TRAM1 CCR5 LRBA ITGB5	1.73e-06	197	82	6	173c0c8de4e69882a9f91189deeb4a651fefe551
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN SRGAP1 LAMA2 ADCY3 LPAR1	1.73e-06	197	82	6	9b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN SRGAP1 LAMA2 DENND5A LPAR1	1.79e-06	198	82	6	a860246bcea847249a78fd2e86ed8e04371060db
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	OTOP2 LAMA2 DAAM2 ITGB5 ADCY3	1.07e-05	157	82	5	bfec34182f052cf1c0d847ba53ea335d4d1190de
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 LAMA2 DAAM2 ATG9A LPAR1	1.13e-05	159	82	5	e812cbde59188924c6277c3feadf1a9592fa62a4
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 LAMA2 DAAM2 ATG9A LPAR1	1.13e-05	159	82	5	2607b562903228274fbd96168ba826782fab0b53
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CASD1 CXCR6 CAPN3 TENM1 LRBA	1.17e-05	160	82	5	8e2b51d7b42e0b6e62641efdbbc73d31561d6a3e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 P2RY11 SRGAP1 LAMA2 LPAR1	1.61e-05	171	82	5	972fab891135bd755d5526cbc5a963200067b0a6
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 P2RY11 SRGAP1 LAMA2 LPAR1	1.61e-05	171	82	5	2a77ed79c6f2e700e789c80451a70ecb31639719
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN LAMA2 DAAM2 ADCY3 LPAR1	1.95e-05	178	82	5	d4ecb84e9b1f4ec49c519321156aa10f9bd34cce
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 LAMA2 DAAM2 ADCY3 LPAR1	1.95e-05	178	82	5	78a0c6340001a77f5b2d890b6263f574af2e72da
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	TENM3 OLFML1 SETD6 LAMA2 LPAR1	2.17e-05	182	82	5	812dac35b9aa05be48258082e007f6c00e7b4dd8
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TENM3 SRGAP1 LAMA2 DAAM2 LPAR1	2.17e-05	182	82	5	e3248d108b51c49ca2c978636e13017e23b53860
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN LAMA2 DAAM2 LPAR1	2.17e-05	182	82	5	44764676ed3f51ba171ce63f669390392fa50a43
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN LAMA2 DAAM2 LPAR1	2.17e-05	182	82	5	d82f59a3f930a840dde27dc6ab024f227a26d446
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NPFFR2 LAMA2 DAAM2 ITGB5 ADCY3	2.29e-05	184	82	5	689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCell	E17.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TENM3 OLFML1 LAMA2 ITGB5 LPAR1	2.35e-05	185	82	5	c85bba1210f1d389add3e40be9b96abac40cf8c1
ToppCell	RA-11._Adipocyte\|World / Chamber and Cluster_Paper	PRUNE2 TENM3 PFKFB1 PFKFB3 ITPR2	2.54e-05	188	82	5	4dac9d636e5cad4cda540b93d4bfed6b5732c880
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN LAMA2 DAAM2 ADCY3	2.67e-05	190	82	5	70c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN LAMA2 DAAM2 LPAR1	2.74e-05	191	82	5	a6c57627077fa980b7ec1d3894b5f31bfb11b738
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CACNA1B MYO9A GLRA2 TENM1 UNC80	2.74e-05	191	82	5	5d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCell	Entopeduncular-Neuronal-Inhibitory\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CACNA1B MYO9A GLRA2 TENM1 UNC80	2.74e-05	191	82	5	73dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN LAMA2 DAAM2 LPAR1	2.74e-05	191	82	5	8f6d592edc32fdb901af30501d4360512334e8c2
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN LAMA2 DAAM2 LPAR1	2.81e-05	192	82	5	bc84b9ce01b4d826a682842ab8a395dac9b91183
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 LAMA2 DAAM2 ADCY3 LPAR1	2.81e-05	192	82	5	d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCell	renal_papilla_nuclei-Adult_normal_reference\|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 SRGAP3 DAAM2 LRBA ITPR1	2.81e-05	192	82	5	6c106b91e46eabbe686a52a65a9c94ad9cbe9390
ToppCell	CD8+_Memory_T_cell-RSV-5\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	SLC16A3 CXCR6 CCR8 PFKFB3 PFKFB4	2.81e-05	192	82	5	6357af0fb60a13a0ac727bc922b7606ab520ef5c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN LAMA2 DAAM2 LPAR1	2.81e-05	192	82	5	0ab1176cfbb0de8dd1f22c6e2c41265cf6c10ee1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 LAMA2 DAAM2 ADCY3 LPAR1	2.88e-05	193	82	5	f1199518c3626fd29bfce65070dd21a660671213
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 LAMA2 DAAM2 ADCY3 LPAR1	2.95e-05	194	82	5	81713e0409e8be695ba5dfdc67a997b33435dd9e
ToppCell	facs-Heart-RA-18m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TENM3 OLFML1 LAMA2 ITGB5 LPAR1	2.95e-05	194	82	5	bc945450b350f597c3ff910d3a14a533d90086a8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 LAMA2 DAAM2 ADCY3 LPAR1	2.95e-05	194	82	5	627cffe2d448e74fc5df92e74e5b922a73304137
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 LAMA2 DAAM2 ADCY3 LPAR1	3.02e-05	195	82	5	d9a5c75d31c6e8bb1e1ab7fd115ac5deb5fb1c8d
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN LAMA2 DAAM2 LPAR1	3.02e-05	195	82	5	803f714d91f2d97ecbee8c15a5139fd9310f66c7
ToppCell	facs-Heart-RA-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TENM3 OLFML1 LAMA2 ITGB5 LPAR1	3.02e-05	195	82	5	690d6e15d7c863fc8f2d33b1f7bf86f019f415c9
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN LAMA2 DAAM2 LPAR1	3.02e-05	195	82	5	4f70157d42a16ff0259bc24a62803c4df4285c44
ToppCell	facs-Heart-RA-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TENM3 OLFML1 LAMA2 ITGB5 LPAR1	3.02e-05	195	82	5	5c05e2bcea3d5d7ebe6325f7187ccf83301053d8
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 LAMA2 DAAM2 ADCY3 LPAR1	3.10e-05	196	82	5	a12dd986df65c36f248cf10815c3b8b6238613b0
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 LAMA2 DAAM2 ADCY3 LPAR1	3.10e-05	196	82	5	3e6803587d8566fd08cb8b290be3b6461743d79c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN SRGAP1 LAMA2 LPAR1	3.18e-05	197	82	5	85a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 LAMA2 DAAM2 ADCY3 LPAR1	3.18e-05	197	82	5	6d027119a5f7ca2aac1b10837e43f9a2bb54db85
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 KALRN SRGAP1 LAMA2 LPAR1	3.18e-05	197	82	5	e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 LAMA2 DAAM2 ADCY3 LPAR1	3.18e-05	197	82	5	b349f8e96d61a4c296af64711e11fc44459a9413
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 LAMA2 DAAM2 ADCY3 LPAR1	3.18e-05	197	82	5	80e153790cef37b743e22a7370ff5b3a6abf147d
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 LAMA2 DAAM2 ADCY3 LPAR1	3.18e-05	197	82	5	c2e390653d5dee7e731c1840cfdab41987dede9b
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B KIFAP3 KALRN UNC80 ITPR1	3.25e-05	198	82	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN LAMA2 DAAM2 ADCY3 LPAR1	3.25e-05	198	82	5	79576525a10ed3e3a9d1608077cd16ecda23376f
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B KIFAP3 KALRN UNC80 ITPR1	3.25e-05	198	82	5	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B KIFAP3 KALRN UNC80 ITPR1	3.25e-05	198	82	5	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Fetal_29-31_weeks-Mesenchymal\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TENM3 KALRN SRGAP1 LAMA2 LPAR1	3.25e-05	198	82	5	21cf4d81386761d09d0f6829c01c198e5524176d
ToppCell	LPS-IL1RA+antiTNF-Unknown-Endothelial\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRUNE2 NPFFR2 NCKIPSD ADCY3	1.04e-04	132	82	4	46c80eab16a70da9f363a9fbdf50bccab0b287d7
ToppCell	LPS-IL1RA+antiTNF-Unknown\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRUNE2 NPFFR2 NCKIPSD ADCY3	1.04e-04	132	82	4	a022c3c41654166cb106f27dc54fa88e8c40f898
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN LAMA2 DAAM2 ADCY3	1.70e-04	150	82	4	8645b9c7f9511ed6cc9afe04440c2873a3094150
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_4\|390C / Donor, Lineage, Cell class and subclass (all cells)	CXCR6 CCR5 CCR8 LRBA	1.88e-04	154	82	4	a90c4c45685eae8d21d03479cfd5a23f6ed3ca07
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMA2 DAAM2 ITGB5 ADCY3	1.97e-04	156	82	4	6365b69ede98bc866e996bc52736b00401aacf6f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACHD1 PFKFB1 ADGRG4 ITPR1	2.07e-04	158	82	4	7960337d87afecf2692ab65e5991f052ceddfacc
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CXCR6 TENM1 CCR5 LRBA	2.12e-04	159	82	4	03d77e7fee40262bf0942aab96b273f1c4f5d8e3
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1B WDR64 LAMA2 UNC80	2.17e-04	160	82	4	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1B WDR64 LAMA2 UNC80	2.17e-04	160	82	4	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 LAMA2 DAAM2 LPAR1	2.28e-04	162	82	4	bfaeff19bb56598fdc8c82be71d51787cf13928f
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 LAMA2 DAAM2 LPAR1	2.33e-04	163	82	4	bbc078761c5043af13d9a6fcf3145a3e300bae5e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 LAMA2 DAAM2 LPAR1	2.33e-04	163	82	4	8e32b6431e1862572663aa6ddc4ea299c6acc8a6
ToppCell	356C-Fibroblasts-Fibroblast-D\|356C / Donor, Lineage, Cell class and subclass (all cells)	TRAM1L1 TENM3 OLFML1 LAMA2	2.50e-04	166	82	4	7286a37b2827f3747469ffd0d76cbe81116db7ee
ToppCell	356C-Fibroblasts-Fibroblast-D-\|356C / Donor, Lineage, Cell class and subclass (all cells)	TRAM1L1 TENM3 OLFML1 LAMA2	2.50e-04	166	82	4	7c2eee0a4f45795a956acf936b85bdb35f1b1624
ToppCell	TCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma-Intrahepatic-2\|TCGA-Bile_Duct / Sample_Type by Project: Shred V9	KIFAP3 MYO9A FASTKD2 DENND5A	2.61e-04	168	82	4	c70bf73bb800e4722cedc35bbc17ea3113d1012d
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition,_dividing_(more_DN)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SRGAP3 POLR1B RBBP9 SLC27A4	2.61e-04	168	82	4	b9db0b1e4fe54a1fe79530d15d206155a1bfac39
ToppCell	Control-Lymphoid-ILC_B\|Lymphoid / Disease state, Lineage and Cell class	SLC16A3 SRGAP3 DENND5A LPAR1	2.61e-04	168	82	4	d7118d39253ed9790908b850088ebfc5a86f4065
ToppCell	COVID-19-Heart-Adipocyte\|Heart / Disease (COVID-19 only), tissue and cell type	PRUNE2 TENM3 CCR8 PFKFB1	2.67e-04	169	82	4	bd39f85b48207955f80ca120a11e15a0124117b9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TENM3 LAMA2 DAAM2 LPAR1	2.67e-04	169	82	4	a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCell	droplet-Lung-nan-21m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC3 CCDC88A SRGAP3 NCKIPSD	2.74e-04	170	82	4	71c52fadecc6b4bfe98692b266adaa1406f6d56d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYO9A SRGAP3 PFKFB3	2.74e-04	170	82	4	5d5f208682be21ed58320f5fc083a7898f8712da
ToppCell	facs-Marrow-T-cells-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SRGAP3 NCKIPSD CCR5 ITPR1	2.80e-04	171	82	4	6a0fafb8fd9fc7671618eeb2bf528ce8ce86b794
ToppCell	facs-Marrow-Granulocytes\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC16A3 GPR141 PFKFB4 SLC27A4	2.80e-04	171	82	4	1701dedf0c18751db6c9fee3d93fff150ed0e17f
ToppCell	facs-Marrow-T-cells-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SRGAP3 NCKIPSD CCR5 ITPR1	2.80e-04	171	82	4	e02b5831768dbb1b68998b672e55c9680ab0cc86
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 DAAM2 PSMD12 LPAR1	2.80e-04	171	82	4	2a34685f7d83d1cf9a88d304173cbca868c5f9fd
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KALRN OLFML1 CXCR6 PFKFB3	2.92e-04	173	82	4	f0eb48c1283bdde313bb75f6ffc0d2626922d24b
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KALRN SRGAP3 TTI1 ATG9A	2.99e-04	174	82	4	a1f745962a104c6f4b86b7e482da8755384c773a
ToppCell	droplet-Lung-18m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_l12\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRUNE2 LRRC3 CCR5 ITGB5	2.99e-04	174	82	4	33e5903adb746f693433bdca11a75c508bbf50c0
ToppCell	droplet-Lung-18m-Hematologic-myeloid-interstitial_macrophage\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRUNE2 LRRC3 CCR5 ITGB5	2.99e-04	174	82	4	ca0c2f42544092848541863c4a47b334e6828b8a
ToppCell	CV-Healthy-4\|Healthy / Virus stimulation, Condition and Cluster	SLC16A3 NCKIPSD PFKFB3 PFKFB4	2.99e-04	174	82	4	26544cc5f51cb4dc1251e62d9f80b6c956194d38
ToppCell	droplet-Lung-nan-21m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC3 SRGAP3 NCKIPSD LRBA	2.99e-04	174	82	4	2afa5eea54b67c549c5058ece98296eee3829c11
ToppCell	343B-Epithelial_cells-Epithelial-A_(AT2)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SLC35G5 DAAM2 SLC35G6	3.05e-04	71	82	3	499262154a694d9f84358de9f5deff0d022c7632
ToppCell	343B-Epithelial_cells-Epithelial-A_(AT2)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SLC35G5 DAAM2 SLC35G6	3.05e-04	71	82	3	00ca08c442de977f909f1691c6fa40e7382d02dd
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC88A PSME4 MYO9A VPS13C	3.12e-04	176	82	4	749b47eac5436fa34e0d243ffbc6f1897f4e431e
Computational	Membranal receptors.	SLC16A3 CXCR6 GLRA2 CCR5 CCR8 PFKFB1 PFKFB3 PFKFB4 ITGB5 LPAR1	9.15e-05	517	49	10	MODULE_64
Drug	glipentide	PFKFB1 PFKFB3 PFKFB4	1.56e-06	7	82	3	CID000065779
Drug	2-MP	PFKFB1 PFKFB3 PFKFB4	2.49e-06	8	82	3	CID003015569
Drug	mitiglinide	CAPN3 PFKFB1 PFKFB3 PFKFB4	2.57e-06	27	82	4	CID000121891
Drug	fructose 2-phosphorothioate 6-phosphate	PFKFB1 PFKFB3 PFKFB4	7.28e-06	11	82	3	CID000195184
Drug	benzoate	SLC16A3 SRGAP3 SRGAP1 PFKFB1 PFKFB3 PFKFB4 ARHGAP8	1.51e-05	221	82	7	CID000000242
Drug	carboxytolbutamide	PFKFB1 PFKFB3 PFKFB4	1.59e-05	14	82	3	CID000159651
Drug	PK-F	PFKFB1 PFKFB3 PFKFB4	1.59e-05	14	82	3	CID000448133
Drug	2-hexulofuranose	CAPN3 PFKFB1 PFKFB3 PFKFB4 ADCY3	1.66e-05	88	82	5	CID000000716
Drug	Thr-Ala	PFKFB1 PFKFB3 PFKFB4	1.99e-05	15	82	3	CID006427021
Drug	dibenzyl succinate	PFKFB1 PFKFB3 PFKFB4	2.44e-05	16	82	3	CID000007653
Drug	N-bromoacetylethanolamine phosphate	PFKFB1 PFKFB3 PFKFB4	2.95e-05	17	82	3	CID000188343
Drug	Ciclopirox ethanolamine [41621-49-2]; Up 200; 15uM; PC3; HT_HG-U133A	SRD5A3 SLC16A3 DAAM2 PFKFB3 PFKFB4 ITPR1	3.14e-05	167	82	6	6677_UP
Drug	AC1L1AO2	PFKFB1 PFKFB3 PFKFB4	3.53e-05	18	82	3	CID000001073
Drug	brazilin	PFKFB1 PFKFB3 PFKFB4	3.53e-05	18	82	3	CID000073384
Drug	Homatropine hydrobromide (R,S) [51-56-9]; Down 200; 11.2uM; MCF7; HT_HG-U133A	CCNT1 AMFR SLC11A2 SLC16A3 HAUS2 ADCY3	7.67e-05	196	82	6	1684_DN
Drug	3-nitropropionic acid; Up 200; 10uM; MCF7; HT_HG-U133A	KALRN CXCR6 GLRA2 TENM1 ITPR1 ITPR2	7.89e-05	197	82	6	6367_UP
Drug	Tetramisole hydrochloride [16595-80-5]; Down 200; 16.6uM; HL60; HT_HG-U133A	AMFR SLC11A2 SLC16A3 FASTKD2 SNRNP200 LPAR1	8.11e-05	198	82	6	2489_DN
Drug	Thalidomide [50-35-1]; Down 200; 15.4uM; HL60; HG-U133A	CCNT1 CCDC88A SETD6 TRAM1 SCAF4 ITPR1	8.11e-05	198	82	6	1411_DN
Drug	Dapsone [80-08-0]; Down 200; 16.2uM; HL60; HT_HG-U133A	SLC11A2 SRD5A3 ABR ITGB5 LPAR1 SCAF4	8.11e-05	198	82	6	1868_DN
Drug	melarsen oxide	PFKFB1 PFKFB3 PFKFB4	8.63e-05	24	82	3	CID000030830
Disease	Anoxic Encephalopathy	ITPR1 ITPR2	7.08e-06	2	79	2	C0003132
Disease	Brain Hypoxia	ITPR1 ITPR2	7.08e-06	2	79	2	C1527348
Disease	Anoxia of brain	ITPR1 ITPR2	7.08e-06	2	79	2	C0995195
Disease	Hypoxic Brain Damage	ITPR1 ITPR2	7.08e-06	2	79	2	C1140716
Disease	Malignant neoplasm of breast	AMFR UTS2R SLC16A3 KALRN SRGAP3 TENM1 LAMA2 PFKFB4 LRBA LPAR1 RUSF1	1.33e-04	1074	79	11	C0006142
Disease	focal segmental glomerulosclerosis (implicated_via_orthology)	MYO9A SRGAP1	1.47e-04	7	79	2	DOID:1312 (implicated_via_orthology)
Disease	Obesity, Morbid	MC4R ADCY3	1.47e-04	7	79	2	C0028756
Disease	vesicular integral-membrane protein VIP36 measurement	KALRN ITGB5	3.14e-04	10	79	2	EFO_0022012
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR1 ITPR2	4.59e-04	12	79	2	DOID:1441 (implicated_via_orthology)
Disease	phosphatidylcholine 36:5 measurement	TRAM1 MC4R	6.31e-04	14	79	2	EFO_0010383
Disease	dental caries, dentures	PRUNE2 MC4R ADCY3	8.89e-04	70	79	3	EFO_0003819, EFO_0010078
Disease	dentures	PRUNE2 MC4R ADCY3	8.89e-04	70	79	3	EFO_0010078
Disease	muscular dystrophy (is_implicated_in)	CAPN3 LAMA2	9.38e-04	17	79	2	DOID:9884 (is_implicated_in)
Disease	citrate measurement	OTULIN CAPN3 PFKFB3	1.26e-03	79	79	3	EFO_0010114
Disease	sex interaction measurement, body mass index, age at assessment	MC4R ADCY3	1.73e-03	23	79	2	EFO_0004340, EFO_0008007, EFO_0008343
Disease	diet measurement, bilirubin measurement	LAMA2 CACHD1	2.21e-03	26	79	2	EFO_0004570, EFO_0008111

Protein segments in the cluster

Peptide	Gene	Start	Entry
DVMAQVQVLLYYLQH	ABR	826	Q12979
VECYMYRRIHEAIIQ	ARMT1	116	Q9H993
IQSRTVYYLMNIHVT	PFKFB1	236	P16118
FHYTIMVTEAIAYLR	CXCR6	266	O00574
AVHMYLALVKVFNIY	ADGRG4	2831	Q8IZF6
CIMVLVLAVYAYRHQ	CACHD1	1106	Q5VU97
LYYEIIRMHQSFDNL	ARMH3	551	Q5T2E6
QLTINTAIVYMHRFY	CCNT1	56	O60563
HRAVRLIFTIMIVYF	CCR5	231	P51681
RFCHYIVTMRYFEVV	CACNA1B	1141	Q00975
EVISVYRMHLLYAVQ	RAI14	941	Q9P0K7
AVMLHVQEEKYYRVR	NPFFR2	281	Q9Y5X5
IAMAVYTYLRLIVDH	INTS3	206	Q68E01
HIHMYLTFLFYVVIL	GPR141	96	Q7Z602
GYRAVILDMAFLYHV	ITPR2	2336	Q14571
ILDMAFLYHVAYVLV	ITPR2	2341	Q14571
AMRYAETHRVYAIVL	RBBP9	81	O75884
VLQAMLHYQVYAAER	DAAM2	236	Q86T65
YVPYHIMRVLNVDAR	P2RY11	261	Q96G91
AVYHRYMVHLLELAV	HAUS2	126	Q9NVX0
YRAMVLDVEFLYHLL	ITPR1	2391	Q14643
KLLDATHVYMYVFIL	SLC16A3	376	O15427
AMVIAYVVYYVRHNQ	LRRC3	216	Q9BY71
MVAIYVNRRFHFPIY	LPAR1	71	Q92633
MVVLYAHIFGYVRQR	LPAR1	221	Q92633
MHNLSILVRQIKFYY	CCDC88A	76	Q3V6T2
RVQDHIQSRIVYYLM	PFKFB3	226	Q16875
IQSRIVYYLMNIHVQ	PFKFB3	231	Q16875
ADHIQSRIVYYLMNI	PFKFB4	231	Q16877
AFYIRDIMEALQYLH	KALRN	2781	O60229
ITEMVYAIFRILLYH	LRBA	886	P50851
NMYFVVVYVRDLGHV	SLC11A2	491	P49281
IHYILIKATYGNFMR	LAMA2	1336	P24043
NRVVEHNIRIMAKYY	PSMD12	356	O00232
INLIFAVTKNHYMLY	ITGB5	331	P18084
IGVHLMDRYTFYVLE	PIGK	241	Q92643
MVHYIYQRFRVLEQG	OLFML1	31	Q6UWY5
FYRMHAVSSLLEVYV	OTOP2	546	Q7RTS6
VMIHVVQYCFGLVYY	SRD5A3	156	Q9H8P0
MFLLAYAVRHTIQVY	OTULIN	291	Q96BN8
VYMHIRVLVAAYLFQ	CASD1	456	Q96PB1
LMSVDRYLAVVHAVY	CCR8	126	P51685
LDIYHRILRFQNYMV	ATG9A	206	Q7Z3C6
YMYRHENVSILFADI	ADCY3	311	O60266
ILLYSQHYQRLMTVA	DENND5A	311	Q6IQ26
VKFHLERQMGYYLIQ	GLRA2	246	P23416
IFYALQYHNIMTVKR	MC4R	151	P32245
FHLNNQLYDIITMRY	CAPN3	756	P20807
AYIVMVHRQDAYRAL	SCAF4	546	O95104
IIYVFYQMVFHQATR	KIFAP3	611	Q92845
MEVIERLIYLYHKFH	NR6A1	366	Q15406
AEFFVLMERYQHYRQ	MRPS26	51	Q9BYN8
HIYANYRAVRALVME	RUSF1	271	Q96GQ5
LHSEVVVALILQYYM	SLC35G5	286	Q96KT7
VVALILQYYMLHETV	SLC35G5	291	Q96KT7
LHSEVVVALILQYYM	SLC35G3	286	Q8N808
VVALILQYYMLHETV	SLC35G3	291	Q8N808
SVLIVMRYLFAFLNH	SRGAP1	626	Q7Z6B7
HYVMENLFLYVISTL	PRUNE2	2936	Q8WUY3
IMQYKYLLFSLHAIV	FASTKD2	226	Q9NYY8
ELYHQLVALVMAYSF	SETD6	211	Q8TBK2
VMLLLHSQRRYIFEY	TENM1	1891	Q9UKZ4
LSFLQRITEYMEHVY	OSBPL2	101	Q9H1P3
VLALVAYYQMEHRAS	NCKIPSD	441	Q9NZQ3
SLVIFMQLRYLFHEV	AMFR	291	Q9UKV5
MLYYNQAVILYHLRQ	CNOT10	111	Q9H9A5
ATVFFYMLVAIIIHA	TRAM1L1	81	Q8N609
YMLVAIIIHATIQEY	TRAM1L1	86	Q8N609
HILFNYLVGLIMYFV	UNC80	1926	Q8N2C7
VVIVVMRYLFAFLNH	SRGAP3	626	O43295
AIVVHSRYYRMAALV	SLC27A4	256	Q6P1M0
KYLLAMVLVYFQRAH	SPDYC	86	Q5MJ68
IMSVIHYFITELQYR	TTC41P	381	Q6P2S7
LLLHSQRQYIFEYDM	TENM3	1871	Q9P273
VVRHYSEQFLKQMYV	VPS13C	3401	Q709C8
HARYTVLTYLQTMVF	PSME4	1656	Q14997
LHSEVVVALILQYYM	SLC35G6	286	P0C7Q6
VVALILQYYMLHETV	SLC35G6	291	P0C7Q6
YVVLRYLMGFLHAVS	ARHGAP8	346	P85298
VAAHLVIIMDTQYYN	SNRNP200	1656	O75643
RAVASMYVYVVNLAL	UTS2R	81	Q9UKP6
ATVFFYMLVAIIIHA	TRAM1	81	Q15629
YMLVAIIIHAVIQEY	TRAM1	86	Q15629
MRNIHIFVSRYLYNL	WASHC4	786	Q2M389
HFFMAVLYVFLHAIL	TAPT1	241	Q6NXT6
DIFIGVVYYQRLRHM	POLR1B	991	Q9H9Y6
VVYYQRLRHMVSDKF	POLR1B	996	Q9H9Y6
ALHYANKYNIMLVRL	CCT8	301	P50990
LYHQSVVYRKQAAMI	TTI1	511	O43156
REINVMLYNKYFHQV	WDR64	456	B1ANS9
YAVADVAYHAMLQRK	MYO9A	216	B2RTY4