Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionSMAD binding

USP9Y IPO7 FERMT2 USP9X

7.02e-0686294GO:0046332
GeneOntologyMolecularFunctionciliary neurotrophic factor receptor binding

LIFR CLCF1

4.26e-057292GO:0005127
GeneOntologyMolecularFunctionco-SMAD binding

USP9Y USP9X

1.33e-0412292GO:0070410
GeneOntologyBiologicalProcesspositive regulation of wound healing, spreading of epidermal cells

FERMT2 FERMT1

2.85e-056292GO:1903691
DomainARM-like

PRKDC IPO8 USP9Y IPO7 TARBP1 USP9X

3.83e-06270306IPR011989
DomainCse1

IPO8 IPO7

7.48e-063302IPR013713
DomainCse1

IPO8 IPO7

7.48e-063302PF08506
DomainARM-type_fold

PRKDC IPO8 USP9Y IPO7 TARBP1 USP9X

1.41e-05339306IPR016024
DomainIMPORTIN_B_NT

IPO8 IPO7

2.24e-0414302PS50166
DomainIBN_N

IPO8 IPO7

2.59e-0415302PF03810
DomainIBN_N

IPO8 IPO7

2.95e-0416302SM00913
DomainImportin-beta_N

IPO8 IPO7

3.34e-0417302IPR001494
Domain-

PRKDC IPO8 IPO7 USP9X

4.18e-042223041.25.10.10
DomainFERM_N

FERMT2 FERMT1

1.28e-0333302IPR018979
DomainFERM_N

FERMT2 FERMT1

1.28e-0333302PF09379
DomainFERM_M

FERMT2 FERMT1

2.47e-0346302PF00373
DomainFERM_central

FERMT2 FERMT1

2.80e-0349302IPR019748
DomainFERM_domain

FERMT2 FERMT1

2.80e-0349302IPR000299
Domain-

FERMT2 FERMT1

2.80e-03493021.20.80.10
DomainFERM_1

FERMT2 FERMT1

2.91e-0350302PS00660
DomainFERM_2

FERMT2 FERMT1

2.91e-0350302PS00661
DomainBand_41_domain

FERMT2 FERMT1

2.91e-0350302IPR019749
DomainB41

FERMT2 FERMT1

2.91e-0350302SM00295
DomainFERM/acyl-CoA-bd_prot_3-hlx

FERMT2 FERMT1

2.91e-0350302IPR014352
DomainFERM_3

FERMT2 FERMT1

2.91e-0350302PS50057
DomainUSP_CS

USP9Y USP9X

5.02e-0366302IPR018200
DomainUSP_1

USP9Y USP9X

5.63e-0370302PS00972
DomainUCH

USP9Y USP9X

5.79e-0371302PF00443
DomainUSP_2

USP9Y USP9X

5.79e-0371302PS00973
DomainUSP_3

USP9Y USP9X

5.95e-0372302PS50235
DomainUSP_dom

USP9Y USP9X

5.95e-0372302IPR028889
DomainPeptidase_C19_UCH

USP9Y USP9X

5.95e-0372302IPR001394
Pubmed

Intrahepatic paracrine signaling by cardiotrophin-like cytokine factor 1 ameliorates diet-induced NASH in mice.

LIFR CLCF1

7.19e-07230235950514
Pubmed

UV-B-induced cutaneous inflammation and prospects for antioxidant treatment in Kindler syndrome.

FERMT2 FERMT1

7.19e-07230227798104
Pubmed

Kindlin-1 and -2 have overlapping functions in epithelial cells implications for phenotype modification.

FERMT2 FERMT1

7.19e-07230221356350
Pubmed

The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2.

USP9Y USP9X

7.19e-0723028922996
Pubmed

Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.

USP9Y USP9X

7.19e-07230212925892
Pubmed

Differential expression of Kindlin-1 and Kindlin-2 correlates with esophageal cancer progression and epidemiology.

FERMT2 FERMT1

7.19e-07230228667517
Pubmed

Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome.

USP9Y USP9X

7.19e-07230212895410
Pubmed

Preferential utilization of Imp7/8 in nuclear import of Smads.

IPO8 IPO7

2.16e-06330218519565
Pubmed

Opposite role of Kindlin-1 and Kindlin-2 in lung cancers.

FERMT2 FERMT1

2.16e-06330223209705
Pubmed

URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas.

FERMT2 FERMT1

2.16e-06330212697302
Pubmed

Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome.

FERMT2 FERMT1

2.16e-06330218528435
Pubmed

The Kindlins: subcellular localization and expression during murine development.

FERMT2 FERMT1

2.16e-06330216876785
Pubmed

Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome.

FERMT2 FERMT1

2.16e-06330212789646
Pubmed

The role of kindlins in cell biology and relevance to human disease.

FERMT2 FERMT1

2.16e-06330219854292
Pubmed

Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail.

FERMT2 FERMT1

4.31e-06430222561348
Pubmed

The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine.

LIFR CLCF1

4.31e-06430211285233
Pubmed

Glycosylation Changes in Serum Proteins Identify Patients with Pancreatic Cancer.

LIFR VPS13A

4.31e-06430228244758
Pubmed

Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics.

FERMT2 FERMT1

4.31e-06430224165133
Pubmed

A novel class of RanGTP binding proteins.

IPO8 IPO7

7.18e-0653029214382
Pubmed

Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes.

LIFR CLCF1

7.18e-06530217436251
Pubmed

Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin.

FERMT2 FERMT1

7.18e-06530226821125
Pubmed

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

PRKDC MOGAT1 IPO8 IPO7 FERMT2 CBS USP9X

7.82e-0687830737223481
Pubmed

Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin.

IPO8 IPO7

1.51e-05730211682607
Pubmed

Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation.

FERMT2 FERMT1

1.51e-05730225086068
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

IPO7 TARBP1 USP9X POLE SYNE2 VPS13A

1.52e-0563830631182584
Pubmed

Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.

PRKDC IPO8 IPO7 USP9X

1.83e-0518330423956138
Pubmed

Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.

IPO8 IPO7

2.01e-05830227114554
Pubmed

Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor.

LIFR CLCF1

2.58e-05930215051883
Pubmed

Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene.

USP9Y USP9X

3.22e-05103029384609
Pubmed

Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation.

PRKDC IPO8 IPO7

3.32e-057230336376293
Pubmed

Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis.

USP9Y USP9X

4.72e-051230223861879
Pubmed

Kindlin-2 Is Essential for Preserving Integrity of the Developing Heart and Preventing Ventricular Rupture.

FERMT2 FERMT1

4.72e-051230230883226
Pubmed

Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla.

LIFR CLCF1

5.58e-051330216467531
Pubmed

Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication.

PRKDC POLE

7.50e-051530212393188
Pubmed

IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration.

PRKDC USP9X

7.50e-051530218303054
Pubmed

Deubiquitinating enzymes: a new class of biological regulators.

USP9Y USP9X

7.50e-05153029827704
Pubmed

Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesis.

FERMT2 FERMT1

7.50e-051530226151572
Pubmed

Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.

USP9Y USP9X

7.50e-051530214762062
Pubmed

Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells.

IPO8 IPO7 USP9X

7.60e-059530329490077
Pubmed

A strategy for modulation of enzymes in the ubiquitin system.

USP9Y USP9X

9.70e-051730223287719
Pubmed

Sex differences in sex chromosome gene expression in mouse brain.

USP9Y USP9X

1.09e-041830212023983
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

PRKDC ARIH1 IPO8 IPO7 CBS USP9X WDR87

1.13e-04133530729229926
Pubmed

Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.

PRKDC IPO8 IPO7

1.27e-0411330330352685
Pubmed

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

PRKDC IPO8 IPO7 USP9X

1.60e-0432030428685749
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

LIFR PRKDC ARIH1 IPO7 TMEM245

1.66e-0461330522268729
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

PRKDC IPO8 IPO7 CBS USP9X POLE RGS22

1.70e-04142530730948266
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

PRKDC IPO8 IPO7 CBS USP9X

1.99e-0463830533239621
Pubmed

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

PRKDC IPO7 FERMT2 USP9X

2.10e-0434430430333137
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

LIFR IPO8 IPO7 FERMT2 POLE SYNE2 VPS13A

2.20e-04148730733957083
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

PRKDC IPO7 USP9X POLE SYNE2

2.22e-0465330522586326
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

PRKDC IPO8 IPO7 USP9X VPS13A

2.28e-0465730536180527
Pubmed

Evidence that the transcriptional repressor ICER is regulated via the N-end rule for ubiquitination.

PRKDC IPO7

2.68e-042830235227662
Pubmed

The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.

OAS2 SYNE2

3.08e-043030230480076
Pubmed

Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.

PRKDC IPO8 IPO7 CBS

3.16e-0438330429331416
Pubmed

A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.

PRKDC POLE

3.29e-043130212171929
Pubmed

Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.

IPO8 IPO7 FERMT2

3.54e-0416030331678930
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

KMT2C PRKDC IPO7 SYNE2

3.66e-0439830435016035
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

KMT2C PRKDC USP9X

4.01e-0416730320362541
Pubmed

Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.

PRKDC IPO8 USP9X VPS13A

4.02e-0440830433766124
Pubmed

Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies.

COL2A1 LIFR

4.20e-043530232179912
Pubmed

TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.

PRKDC IPO7 USP9X

4.91e-0417930336261009
Pubmed

Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.

PRKDC CBS USP9X

5.16e-0418230332239614
Pubmed

Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif.

PRKDC USP9X

5.50e-044030230865227
Pubmed

Revealing A-Raf functions through its interactome.

PRKDC IPO8 IPO7

5.58e-0418730329777862
Pubmed

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.

PRKDC IPO7 USP9X

6.30e-0419530317110338
Pubmed

Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment.

COL2A1 PRKDC

6.65e-044430221308778
Pubmed

AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.

PRKDC IPO7 CBS

6.78e-0420030335546148
Pubmed

Aire's partners in the molecular control of immunological tolerance.

PRKDC IPO7

6.96e-044530220085707
Pubmed

Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin.

KMT2C IPO7

7.92e-044830227703004
Pubmed

Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.

PRKDC IPO7 POLE

7.92e-0421130317314511
Pubmed

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.

COL2A1 KMT2C

8.25e-044930234368113
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

KMT2C USP9Y USP9X HPX

8.41e-0449730436774506
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

IPO7 FERMT2 USP9X SYNE2

8.47e-0449830436634849
Pubmed

PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.

PRKDC IPO7 USP9X

8.59e-0421730331685992
InteractionRPS6KA2 interactions

PRKDC IPO8 IPO7 FERMT2 USP9X

9.67e-06196305int:RPS6KA2
InteractionFAM234A interactions

TAS2R8 PRKDC IPO7 TARBP1

3.52e-05126304int:FAM234A
GeneFamilyFermitins|Pleckstrin homology domain containing|FERM domain containing

FERMT2 FERMT1

3.85e-063212561
GeneFamilyArmadillo repeat containing|Importins

IPO8 IPO7

1.94e-0418212596
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

FERMT2 FERMT1

1.52e-03502121293
GeneFamilyUbiquitin specific peptidases

USP9Y USP9X

1.91e-0356212366
CoexpressionGSE30083_SP1_VS_SP4_THYMOCYTE_DN

OAS2 PRKDC CLCF1 IL21R SYNE2

3.00e-06200305M5030
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

KMT2C USP9X POLE TMEM245

5.13e-05180304M8239
CoexpressionGSE34156_UNTREATED_VS_24H_NOD2_LIGAND_TREATED_MONOCYTE_UP

PRKDC FERMT2 TRPC4 VPS13A

6.46e-05191304M8681
CoexpressionGSE33162_UNTREATED_VS_4H_LPS_STIM_HDAC3_HET_MACROPHAGE_UP

COL2A1 OAS2 TMEM245 IL21R

7.42e-05198304M9035
CoexpressionGSE22140_GERMFREE_VS_SPF_ARTHRITIC_MOUSE_CD4_TCELL_UP

OAS2 USP9Y IPO7 FERMT2

7.72e-05200304M7649
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P5-P5_2-Sox4-POLYDENDROCYTE_(Neurogenesis.Sox4.Efhd2)|Hippocampus / BrainAtlas - Mouse McCarroll V32

COL2A1 SULT1B1 WDR87 POLE

2.71e-078230493b75f8822ffe8870195cd1fe0a7286478f61e79
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

OAS2 KMT2C USP9X SYNE2

6.68e-061833048f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

KMT2C ARIH1 USP9X SYNE2

7.43e-06188304ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellEntopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Pdgfa_(Mural.Rgs5Acta2.Pdgfa)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

MOGAT1 CLCF1 POLE

6.12e-05114303fceb7cc590a47380145fc0d854c9f2350dbb0a59
ToppCellEntopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Pdgfa_(Mural.Rgs5Acta2.Pdgfa)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

MOGAT1 CLCF1 POLE

6.12e-051143032cc5d2da5573650c5232a01e2d2128082c4bffcb
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

KMT2C ARIH1 SYNE2

1.55e-041563031545169694f686d28648a68b552c2ae606599d66
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PRKDC SYNE2 VPS13A

1.89e-0416730383969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD8-Trm_gut_CD8|lymph-node_spleen / Manually curated celltypes from each tissue

TAS2R8 SYNE2 FERMT1

1.89e-0416730369de7d7fc69d699eab03dfea84fdb54263aa5a47
ToppCellnormal_Pleural_Fluid-Myeloid_cells-CD163+CD14+_DCs|Myeloid_cells / Location, Cell class and cell subclass

SYNE2 FERMT1 VPS13A

1.96e-04169303bea8aba1f3cc3d0e8d448c1c45f5354d26ebf850
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

FERMT2 CRAT POLE

1.96e-04169303c6e5b179461996ced6c7621dc01cec00d401f4e8
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

FERMT2 CRAT POLE

1.96e-04169303ea600c63cf9572bc4b3cad6392f67bd0d92c7fc9
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OAS2 TMEM245 RGS22

2.00e-0417030317bd7fd25a2657cb536ad47e294332920f759e95
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR CDR1 HPX

2.10e-04173303869da6a65d1b9b7529c666ec44e3c8ddec2ea408
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR CDR1 HPX

2.10e-041733030672bd8a4a9d18af343d01f09253fb3388896c10
ToppCellfacs-Brain_Myeloid-Cerebellum-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR CDR1 HPX

2.10e-04173303870e091ec30be01a900e1cb8b9ef1880e3b7b50d
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR CDR1 HPX

2.17e-041753031ea6cf9da26601646f57fa14d558a5e9e1f0b345
ToppCellHealthy_Control-Lymphoid-T-Treg|Healthy_Control / Condition, Lineage, Cell class and cell subclass

GJC3 IL21R SYNE2

2.21e-041763037765a5b04ac117d525201f8eb08e1754e55942ff
ToppCellfacs-Kidney-nan-3m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR USP9X HPX

2.44e-041823034c5d14e33ebdf117b5aa9e2f57aaa89aa51f72bf
ToppCellCOVID-19-kidney-PCT-S1|kidney / Disease (COVID-19 only), tissue and cell type

MOGAT1 SYNE2 VPS13A

2.52e-0418430351ed1ebfdef45149541917c66cbacad87072e51f
ToppCellCerebellum-Macroglia|Cerebellum / BrainAtlas - Mouse McCarroll V32

COL2A1 GJC3 CBS

2.52e-0418430391b047a01d2cad231308279ca37fa699630f7864
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L3-4_RORB_RPS3P6|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CDR1 MOGAT1 TRPC4

2.56e-0418530310da5c2a92bfb3248d3f6f94a0933996326cf590
ToppCellPBMC-Mild-cDC_12|Mild / Compartment, Disease Groups and Clusters

PRKDC CBS POLE

2.72e-04189303946c95d2ecc36b241f58e8c4ad6455fe47c762fa
ToppCellrenal_cortex_nuclei-Adult_normal_reference|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

LIFR TMEM245 SYNE2

2.72e-04189303a48df46274d51e84ffb40264646de7346104efb9
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

KMT2C ARIH1 SYNE2

2.85e-0419230347646d7e4990be85072987f92bf18d52f8da752e
ToppCellCOVID-19_Severe-Lymphoid_T/NK-CD4+_T_activated|COVID-19_Severe / Disease group, lineage and cell class

OAS2 USP9Y SYNE2

2.90e-04193303beb862d38b88572836b0a797c8efef7a2492e0b9
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

OAS2 USP9Y SYNE2

2.90e-04193303f4310faa13fc8ce99a217e2d1c9cc733683797a1
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

OAS2 USP9Y SYNE2

2.90e-041933032901d7a9672a8cf70c9f1c752685b45e4d79ac70
ToppCellAT2_cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

LIFR GJC3 TMEM245

2.90e-041933038187f976fd2d11fad3286690f1a046e894772220
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

OAS2 USP9Y SYNE2

2.90e-04193303f8af695457d2a0a911a5ac491742465864ebda37
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

OAS2 USP9Y SYNE2

2.90e-04193303089aece40130034a89a5213be778f10b0787eeba
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

USP9Y SYNE2 VPS13A

2.90e-041933039337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2C USP9X VPS13A

2.99e-041953033e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2C USP9X VPS13A

2.99e-041953037796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellBronchial-10x5prime-Immune_Lymphocytic-T-T_CD4-T_reg|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TAS2R8 IL21R SYNE2

3.03e-04196303b60e5bf9a45c08e0ca12c7e2ac2009ea53e04f4e
ToppCellCV-Moderate-6|CV / Virus stimulation, Condition and Cluster

KMT2C ARIH1 IL21R

3.03e-041963037bced0cc2112697593c478fa291b8ed3941fb811
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-skeletal_muscle_satellite_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IPO7 CLCF1 USP9X

3.08e-041973035bc11aff92da2a0aca8473f997fe7a99f3cae75d
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

KMT2C SYNE2 VPS13A

3.08e-0419730357ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellmild-low-quality_cells|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

USP9Y SYNE2 VPS13A

3.08e-04197303e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCellLPS_only-Endothelial-Endothelial-FOXM1|LPS_only / Treatment groups by lineage, cell group, cell type

OAS2 TMEM245 RGS22

3.08e-04197303038fd92750257d43d5e980fd06d77742b543f11a
ToppCellControl-Control-Lymphocyte-T/NK-NK_activated|Control / Disease, condition lineage and cell class

OAS2 POLE SYNE2

3.12e-0419830376d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCellTracheal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_pulmonary_venous|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

LIFR SULT1B1 IL21R

3.12e-041983036fd984da5d2c419aeb34c8cbd8a00440e2f820a5
ToppCellTracheal-10x5prime-Stromal-Chondrocytic-Chondrocyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

COL2A1 LIFR CDR1

3.12e-0419830355f013e9e6587d9ece59751fa131b1d22d6cceea
ToppCellTracheal-10x5prime-Stromal-Chondrocytic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

COL2A1 LIFR CDR1

3.12e-04198303c72ef2ddcbb6dacbed4c6200d89e17d57314dcdc
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CLCF1 IL21R SYNE2

3.17e-041993030902b08e3386e64d7347c186d9ce5b67f2deaabb
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

USP9Y SYNE2 VPS13A

3.17e-04199303f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LIFR KMT2C PRKDC

3.17e-04199303a900ef002e1ae583b70be0253d8c44dae6754916
ToppCellLPS_IL1RA-Endothelial-Endothelial-FOXM1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

POLE RGS22 SYNE2

3.17e-04199303be2276c9a1994579ba1d2998b49bf549c1324d44
ToppCellVE-CD4-antiviral_CD4|VE / Condition, Cell_class and T cell subcluster

OAS2 TARBP1 SYNE2

3.17e-04199303056a0538ca5e825ae6195b4c76c208708a014533
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

LIFR KMT2C SYNE2

3.22e-04200303dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated|COVID-19_Mild / Disease, condition lineage and cell class

OAS2 USP9Y SYNE2

3.22e-042003032281debd86e5d92e8fe0397aec9ef670800f7471
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.

COL2A1 CBS SYNE2

3.22e-042003037c495030e6566b81d97b5516d1972e335ce5ed8c
ToppCellCOVID-19|World / Disease, condition lineage and cell class

OAS2 KMT2C SYNE2

3.22e-042003037dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

OAS2 FERMT2 SYNE2

3.22e-04200303edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCellControl_saline-Endothelial-Endothelial-Alv_Gen_Intermediate|Control_saline / Treatment groups by lineage, cell group, cell type

LIFR OAS2 FERMT2

3.22e-04200303041a34080120c9f613373c20dcc366292f558040
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-T/NK-CD4+_T_activated|COVID-19_Severe / Disease, condition lineage and cell class

OAS2 USP9Y SYNE2

3.22e-04200303deeed668b129e66156b5f6abe1a07a9bf842a14d
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

OAS2 FERMT2 SYNE2

3.22e-0420030379e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

OAS2 KMT2C SYNE2

3.22e-0420030312f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated|COVID-19_Mild / Disease, condition lineage and cell class

OAS2 USP9Y SYNE2

3.22e-04200303d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.

USP9Y CBS SYNE2

3.22e-042003032d167b6e3f4b47e537b2e5b9b2f104f80573970b
DrugApramycin [37321-09-8]; Up 200; 7.4uM; HL60; HT_HG-U133A

COL2A1 OAS2 SULT1B1 CLCF1 IL21R

5.37e-061963052914_UP
Drugchlorophenols

CBS POLE TMEM245

1.43e-0536303CID000006028
Drugmevaldate(1-)

CDR1 CBS SYNE2

2.64e-0544303CID000164657
DrugD -Adonose

CRAT CBS HPX

2.82e-0545303CID000079021
DrugNSC-277174

COL2A1 ARIH1 CBS

3.43e-0548303CID000002171
Drugdehydroalanine

OAS2 SULT1B1 CBS

4.12e-0551303CID000123991
DrugRisarestat

COL2A1 ARIH1

4.68e-058302CID000133264
Diseaseovarian cancer (implicated_via_orthology)

CBS POLE

2.42e-058282DOID:2394 (implicated_via_orthology)
DiseaseDrug-induced depressive state

OAS2 CBS

5.70e-0512282C0338715
Diseaseosteochondrodysplasia (is_implicated_in)

COL2A1 LIFR

1.47e-0419282DOID:2256 (is_implicated_in)
DiseaseSevere Combined Immunodeficiency

PRKDC IL21R

1.63e-0420282C0085110
DiseaseCombined immunodeficiency

PRKDC IL21R

6.96e-0441282C0494261

Protein segments in the cluster

PeptideGeneStartEntry
LWWEQKHCWLLKTHW

FERMT1

61

Q9BQL6
ARKTENWLSEWWLKT

CRAT

91

P43155
LTDWKTWISFWKTLI

CDR1

231

P51861
WWSSKSKEKKHIWFG

COL2A1

1336

P02458
WHDPVKCKWLKKWIK

ARIH1

311

Q9Y4X5
RSSWIKNWTLWKHFK

MOGAT1

71

Q96PD6
VLLGLGRWWRTWKHK

GJC3

211

Q8NFK1
GRWWRTWKHKSSSSK

GJC3

216

Q8NFK1
KWRGMKWKKWSIHIV

KMT2C

4351

Q8NEZ4
PWWKCKKWALHILAR

IPO7

256

O95373
EEWLVWLRFHKKKWQ

POLE

1266

Q07864
WCWHLLAKEAKEWLS

OAS2

651

P29728
DLTEKKPWWWHLRVQ

CBS

401

P35520
AFWSLKTHPLWRLWK

IL21R

251

Q9HBE5
KTHPLWRLWKKIWAV

IL21R

256

Q9HBE5
KLDVKKDWSDHALWW

FERMT2

51

Q96AC1
KDWSDHALWWEKKRT

FERMT2

56

Q96AC1
HALWWEKKRTWLLKT

FERMT2

61

Q96AC1
FWKWSKWSNKKQHLT

LIFR

516

P42702
LVWWKCKKWALHIVA

IPO8

256

O15397
WKSHKWDRELISERW

HPX

76

P02790
LKRKWTWAVEWLGDE

USP9X

2411

Q93008
LWEKWLSLLEAAKEW

SYNE2

3446

Q8WXH0
WWLWMDIERLKVLKD

RGS22

431

Q8NE09
GSWFTHVKNWWKKKE

SULT1B1

171

O43704
WLLKELQTWLWRSAK

CLCF1

186

Q9UBD9
RLWMWSWKHIRKHRQ

VPS13A

346

Q96RL7
DLKRKWTWAVEWLGD

USP9Y

2411

O00507
TILQHWKKCDSWWAK

PRKDC

1621

P78527
LWHWLNKKMIIWLEK

TMEM245

441

Q9H330
WLKWKIDMVVHWILL

TAS2R8

121

Q9NYW2
WWSERKKDELLKFWE

TARBP1

316

Q13395
HGETRKSWKAWKEEW

WDR87

1471

Q6ZQQ6
KSWKAWKEEWEKRLL

WDR87

1476

Q6ZQQ6
LWYLIKWIWTHLCKK

TRPC4

666

Q9UBN4