Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	tyrosine-ester sulfotransferase activity	SULT1A2 SULT1A1	4.29e-05	4	54	2	GO:0017067
GeneOntologyMolecularFunction	amine sulfotransferase activity	SULT1A2 SULT1A1	4.29e-05	4	54	2	GO:0047685
GeneOntologyMolecularFunction	flavonol 3-sulfotransferase activity	SULT1A2 SULT1A1	7.14e-05	5	54	2	GO:0047894
GeneOntologyMolecularFunction	MAP kinase kinase kinase kinase activity	MAP4K5 MAP4K1	1.07e-04	6	54	2	GO:0008349
GeneOntologyMolecularFunction	steroid sulfotransferase activity	SULT1A2 SULT1A1	1.49e-04	7	54	2	GO:0050294
GeneOntologyMolecularFunction	sulfate binding	SULT1A2 SULT1A1	2.55e-04	9	54	2	GO:0043199
GeneOntologyMolecularFunction	aryl sulfotransferase activity	SULT1A2 SULT1A1	3.19e-04	10	54	2	GO:0004062
GeneOntologyMolecularFunction	3'-phosphoadenosine 5'-phosphosulfate binding	SULT1A2 SULT1A1	5.49e-04	13	54	2	GO:0050656
GeneOntologyMolecularFunction	phosphotransferase activity, for other substituted phosphate groups	AASDHPPT PIGO	1.60e-03	22	54	2	GO:0016780
GeneOntologyMolecularFunction	telomerase RNA binding	XRN1 PARN	2.07e-03	25	54	2	GO:0070034
GeneOntologyBiologicalProcess	carbohydrate derivative metabolic process	AMPD1 SULT1A2 SPAM1 PIGP SULT1A1 ST3GAL5 ARFGEF1 GMPR AATF PIGU PIGO ADCY8 ALG1	1.22e-05	1226	54	13	GO:1901135
GeneOntologyBiologicalProcess	carbohydrate derivative biosynthetic process	AMPD1 PIGP ST3GAL5 ARFGEF1 GMPR AATF PIGU PIGO ADCY8 ALG1	1.82e-05	736	54	10	GO:1901137
GeneOntologyBiologicalProcess	glycolipid biosynthetic process	PIGP ST3GAL5 PIGU PIGO	6.01e-05	81	54	4	GO:0009247
GeneOntologyBiologicalProcess	4-nitrophenol metabolic process	SULT1A2 SULT1A1	6.69e-05	5	54	2	GO:0018960
GeneOntologyBiologicalProcess	GPI anchor biosynthetic process	PIGP PIGU PIGO	8.75e-05	33	54	3	GO:0006506
GeneOntologyBiologicalProcess	GPI anchor metabolic process	PIGP PIGU PIGO	1.05e-04	35	54	3	GO:0006505
GeneOntologyBiologicalProcess	IMP salvage	AMPD1 GMPR	2.39e-04	9	54	2	GO:0032264
GeneOntologyBiologicalProcess	glycolipid metabolic process	PIGP ST3GAL5 PIGU PIGO	2.67e-04	119	54	4	GO:0006664
GeneOntologyBiologicalProcess	liposaccharide metabolic process	PIGP ST3GAL5 PIGU PIGO	2.75e-04	120	54	4	GO:1903509
Domain	MAPKKKK	MAP4K5 MAP4K1	4.72e-05	4	53	2	IPR021160
Domain	ARM-type_fold	PPP2R5D DOCK11 CKAP5 ARFGEF1 WDFY3 TRRAP	3.83e-04	339	53	6	IPR016024
Domain	CNH	MAP4K5 MAP4K1	7.03e-04	14	53	2	SM00036
Domain	CNH	MAP4K5 MAP4K1	8.10e-04	15	53	2	PF00780
Domain	CNH	MAP4K5 MAP4K1	8.10e-04	15	53	2	PS50219
Domain	CNH_dom	MAP4K5 MAP4K1	8.10e-04	15	53	2	IPR001180
Domain	-	CKAP5 ARFGEF1 WDFY3 TRRAP	3.61e-03	222	53	4	1.25.10.10
Domain	Sulfotransferase_dom	SULT1A2 SULT1A1	4.68e-03	36	53	2	IPR000863
Domain	Sulfotransfer_1	SULT1A2 SULT1A1	4.68e-03	36	53	2	PF00685
Domain	ABC_transporter_CS	ABCA10 ABCB4	6.33e-03	42	53	2	IPR017871
Domain	-	SPAM1 GMPR	6.33e-03	42	53	2	3.20.20.70
Domain	Aldolase_TIM	SPAM1 GMPR	6.93e-03	44	53	2	IPR013785
Domain	ARM-like	CKAP5 ARFGEF1 WDFY3 TRRAP	7.18e-03	270	53	4	IPR011989
Domain	ABC_tran	ABCA10 ABCB4	8.20e-03	48	53	2	PF00005
Domain	ABC_TRANSPORTER_2	ABCA10 ABCB4	8.20e-03	48	53	2	PS50893
Domain	ABC_TRANSPORTER_1	ABCA10 ABCB4	8.53e-03	49	53	2	PS00211
Domain	ABC_transporter-like	ABCA10 ABCB4	8.87e-03	50	53	2	IPR003439
Pathway	KEGG_MEDICUS_REFERENCE_GPI_ANCHOR_BIOSYNTHESIS	PIGP PIGU PIGO	6.27e-05	24	46	3	M47625
Pathway	KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS	PIGP PIGU PIGO	7.11e-05	25	46	3	M13265
Pathway	KEGG_MEDICUS_ENV_FACTOR_PHIP_TO_DNA_ADDUCTS	SULT1A2 SULT1A1	1.04e-04	5	46	2	M47807
Pathway	WP_ARYLAMINE_METABOLISM	SULT1A2 SULT1A1	1.55e-04	6	46	2	M39437
Pubmed	Crystal structures of SULT1A2 and SULT1A1 *3: insights into the substrate inhibition and the role of Tyr149 in SULT1A2.	SULT1A2 SULT1A1	2.37e-06	2	54	2	20417180
Pubmed	Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2.	SULT1A2 SULT1A1	2.37e-06	2	54	2	10762004
Pubmed	Localisation of aryl sulfotransferase expression in human tissues using hybridisation histochemistry and immunohistochemistry.	SULT1A2 SULT1A1	2.37e-06	2	54	2	9566757
Pubmed	Single nucleotide polymorphisms in SULT1A1 and SULT1A2 in a Korean population.	SULT1A2 SULT1A1	2.37e-06	2	54	2	23358261
Pubmed	Sulfation pharmacogenetics: SULT1A1 and SULT1A2 allele frequencies in Caucasian, Chinese and African-American subjects.	SULT1A2 SULT1A1	2.37e-06	2	54	2	11207031
Pubmed	Genetic polymorphisms of sulfotransferases (SULT1A1 and SULT1A2) in a Turkish population.	SULT1A2 SULT1A1	2.37e-06	2	54	2	20936502
Pubmed	The relationship among the polymorphisms of SULT1A1, 1A2 and different types of cancers in Taiwanese.	SULT1A2 SULT1A1	2.37e-06	2	54	2	12469224
Pubmed	Genetic polymorphisms and linkage disequilibrium of sulfotransferase SULT1A1 and SULT1A2 in a Korean population: comparison of other ethnic groups.	SULT1A2 SULT1A1	2.37e-06	2	54	2	16133548
Pubmed	Structural similarity and diversity of sulfotransferases.	SULT1A2 SULT1A1	2.37e-06	2	54	2	8033246
Pubmed	Primary structures and properties of two related forms of aryl sulfotransferases in human liver.	SULT1A2 SULT1A1	2.37e-06	2	54	2	7581483
Pubmed	Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16.	SULT1A2 SULT1A1	7.09e-06	3	54	2	8912648
Pubmed	Genotypes of CYP1A1, SULT1A1 and SULT1A2 and risk of squamous cell carcinoma of esophagus: outcome of a case-control study from Kashmir, India.	SULT1A2 SULT1A1	7.09e-06	3	54	2	26455829
Pubmed	Genetic polymorphisms in platelet-related proteins and coronary artery disease: investigation of candidate genes, including N-acetylgalactosaminyltransferase 4 (GALNT4) and sulphotransferase 1A1/2 (SULT1A1/2).	SULT1A2 SULT1A1	7.09e-06	3	54	2	18259693
Pubmed	Human phenol sulfotransferase STP2 gene: molecular cloning, structural characterization, and chromosomal localization.	SULT1A2 SULT1A1	1.42e-05	4	54	2	8661000
Pubmed	Steroid sulfotransferases.	SULT1A2 SULT1A1	1.42e-05	4	54	2	8943792
Pubmed	Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7.	SULT1A2 SULT1A1	1.42e-05	4	54	2	8288252
Pubmed	A single mutation converts the nucleotide specificity of phenol sulfotransferase from PAP to AMP.	SULT1A2 SULT1A1	1.42e-05	4	54	2	12390022
Pubmed	Formation of hepatic DNA adducts by methyleugenol in mouse models: drastic decrease by Sult1a1 knockout and strong increase by transgenic human SULT1A1/2.	SULT1A2 SULT1A1	1.42e-05	4	54	2	24318996
Pubmed	Molecular cloning of cDNA encoding the phenol/aryl form of sulfotransferase (mSTp1) from mouse liver.	SULT1A2 SULT1A1	1.42e-05	4	54	2	8424956
Pubmed	Bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study.	SULT1A2 SULT1A1	1.42e-05	4	54	2	25370010
Pubmed	Decreased phenol sulfotransferase activities associated with hyperserotonemia in autism spectrum disorders.	SULT1A2 SULT1A1	1.42e-05	4	54	2	33414449
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	MED16 RADX XRN1 CKAP5 PDCD11 AATF DBT TRRAP	2.13e-05	759	54	8	35915203
Pubmed	Sulfation of afimoxifene, endoxifen, raloxifene, and fulvestrant by the human cytosolic sulfotransferases (SULTs): A systematic analysis.	SULT1A2 SULT1A1	2.36e-05	5	54	2	26169578
Pubmed	Identification of a new subfamily of sulphotransferases: cloning and characterization of canine SULT1D1.	SULT1A2 SULT1A1	2.36e-05	5	54	2	11389699
Pubmed	Hemoglobin adducts of furfuryl alcohol in genetically modified mouse models: Role of endogenous sulfotransferases 1a1 and 1d1 and transgenic human sulfotransferases 1A1/1A2.	SULT1A2 SULT1A1	2.36e-05	5	54	2	29908303
Pubmed	Determination of sulfotransferase forms involved in the metabolic activation of the genotoxicant 1-hydroxymethylpyrene using bacterially expressed enzymes and genetically modified mouse models.	SULT1A2 SULT1A1	2.36e-05	5	54	2	24802129
Pubmed	The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins.	MAP4K5 MAP4K1	2.36e-05	5	54	2	9788432
Pubmed	The effect of knockout of sulfotransferases 1a1 and 1d1 and of transgenic human sulfotransferases 1A1/1A2 on the formation of DNA adducts from furfuryl alcohol in mouse models.	SULT1A2 SULT1A1	2.36e-05	5	54	2	25053625
Pubmed	Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects.	XRN1 PARN	4.94e-05	7	54	2	26950371
Pubmed	The mouse Plk gene: structural characterization, chromosomal localization and identification of a processed Plk pseudogene.	SULT1A2 SULT1A1	4.94e-05	7	54	2	9370299
Pubmed	Chromosomal localization of three vacuolar-H+ -ATPase 16 kDa subunit (ATP6V0C) genes in the murine genome.	SULT1A2 SULT1A1	4.94e-05	7	54	2	12438748
Pubmed	Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain.	SULT1A2 SULT1A1	6.59e-05	8	54	2	10594240
Pubmed	The gene encoding the heart/muscle isoform of cytochrome c oxidase subunit VIII maps to mouse chromosome 7.	SULT1A2 SULT1A1	8.46e-05	9	54	2	9166597
Pubmed	Chromosomal localization of the mouse genes encoding the ERK1 and ERK2 isoforms of MAP kinases.	SULT1A2 SULT1A1	8.46e-05	9	54	2	9060415
Pubmed	Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation.	XRN1 PARN	8.46e-05	9	54	2	21876179
Pubmed	Msx3: a novel murine homologue of the Drosophila msh homeobox gene restricted to the dorsal embryonic central nervous system.	SULT1A2 SULT1A1	8.46e-05	9	54	2	8887328
Pubmed	Structure of the human gene (COX6A2) for the heart/muscle isoform of cytochrome c oxidase subunit VIa and its chromosomal location in humans, mice, and cattle.	SULT1A2 SULT1A1	8.46e-05	9	54	2	9177785
Pubmed	Ethanol sulfation by the human cytosolic sulfotransferases: a systematic analysis.	SULT1A2 SULT1A1	8.46e-05	9	54	2	23207770
Pubmed	Molecular characterization and mapping of murine genes encoding three members of the stefin family of cysteine proteinase inhibitors.	SULT1A2 SULT1A1	8.46e-05	9	54	2	8468045
Pubmed	Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases.	SULT1A2 SULT1A1	8.46e-05	9	54	2	19548878
Pubmed	Rat phenol-preferring sulfotransferase genes (Stp and Stp2): localization to mouse chromosomes 7 and 17.	SULT1A2 SULT1A1	1.06e-04	10	54	2	7601475
Pubmed	Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects.	SULT1A2 SULT1A1	1.06e-04	10	54	2	11535246
Pubmed	Localization of the murine cholecystokinin A and B receptor genes.	SULT1A2 SULT1A1	1.29e-04	11	54	2	7613026
Pubmed	Sulfotransferases in the bioactivation of xenobiotics.	SULT1A2 SULT1A1	1.29e-04	11	54	2	11154739
Pubmed	Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes.	SULT1A2 SULT1A1	1.29e-04	11	54	2	9034160
Pubmed	Sulfotransferases: genetics and role in toxicology.	SULT1A2 SULT1A1	1.29e-04	11	54	2	10720750
Pubmed	Tbx6, a mouse T-Box gene implicated in paraxial mesoderm formation at gastrulation.	SULT1A2 SULT1A1	1.29e-04	11	54	2	8954725
Pubmed	Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities.	XRN1 PARN	1.55e-04	12	54	2	14527413
Pubmed	Common variants at five new loci associated with early-onset inflammatory bowel disease.	SULT1A2 SULT1A1	1.55e-04	12	54	2	19915574
Pubmed	Identification of four chromosomal loci determining obesity in a multifactorial mouse model.	SULT1A2 SULT1A1	1.55e-04	12	54	2	7706460
Pubmed	Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival.	PIGP PIGU	1.55e-04	12	54	2	31232685
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	XRN1 CKAP5 PDCD11 AATF DDX60L	1.66e-04	332	54	5	25693804
Pubmed	PHR1 encodes an abundant, pleckstrin homology domain-containing integral membrane protein in the photoreceptor outer segments.	SULT1A2 SULT1A1	1.83e-04	13	54	2	10585447
Pubmed	Structural and chemical profiling of the human cytosolic sulfotransferases.	SULT1A2 SULT1A1	1.83e-04	13	54	2	17425406
Pubmed	Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.	SULT1A2 SULT1A1	2.45e-04	15	54	2	18632753
Pubmed	cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein.	SULT1A2 SULT1A1	2.45e-04	15	54	2	1741163
Pubmed	Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.	MED16 TRRAP	2.45e-04	15	54	2	18418385
Pubmed	A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer.	SULT1A2 SULT1A1	2.80e-04	16	54	2	12419832
Pubmed	Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis.	PIGP PIGO	3.17e-04	17	54	2	11102867
Pubmed	Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples.	SULT1A2 SULT1A1	3.56e-04	18	54	2	20056724
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	ECHDC1 XRN1 CKAP5 DBT	3.59e-04	216	54	4	31519766
Pubmed	Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.	SULT1A2 SULT1A1 TTLL11	4.29e-04	94	54	3	25201988
Pubmed	Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition.	SULT1A1 ABCB4	4.42e-04	20	54	2	21072184
Pubmed	Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell transformation and defect of ovary development†.	SULT1A2 SULT1A1	4.88e-04	21	54	2	32301970
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	XRN1 CKAP5 PDCD11 AATF PARN TRRAP	5.14e-04	653	54	6	22586326
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	RADX ARFGEF1 TRRAP	5.77e-04	104	54	3	31240132
Pubmed	Functional proteomic analysis of human nucleolus.	PDCD11 AATF PARN	6.10e-04	106	54	3	12429849
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	SULT1A2 SULT1A1 ADAM20 MAP4K1 IRS1 ALG1	9.19e-04	730	54	6	34857952
Pubmed	Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.	SULT1A2 SULT1A1	1.00e-03	30	54	2	20529763
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	MAP4K5 XRN1 CKAP5 PDCD11 AATF DDX60L WDFY3 TRRAP	1.09e-03	1353	54	8	29467282
Pubmed	SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome.	MAP4K1 IRS1	1.14e-03	32	54	2	22974441
Pubmed	Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages.	PDCD11 ZNF844	1.14e-03	32	54	2	26142281
Pubmed	Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.	SULT1A2 IRS1	1.36e-03	35	54	2	18992148
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ZNF296 PDCD11 C15orf39 IRS1 WDFY3 TRRAP TBC1D9	1.54e-03	1105	54	7	35748872
Cytoband	16p12.1	SULT1A2 SULT1A1	4.15e-04	25	55	2	16p12.1
Cytoband	20q11.22	PXMP4 PIGU	9.14e-04	37	55	2	20q11.22
Cytoband	3q23	TRPC1 XRN1	1.29e-03	44	55	2	3q23
Cytoband	Ensembl 112 genes in cytogenetic band chr3q23	TRPC1 XRN1	2.63e-03	63	55	2	chr3q23
Cytoband	Ensembl 112 genes in cytogenetic band chr20q11	PXMP4 BPIFB6 PIGU	3.32e-03	248	55	3	chr20q11
GeneFamily	Glycosyl transferases group 1 domain containing\|Phosphatidylinositol glycan anchor biosynthesis	PIGP PIGU PIGO	7.20e-06	21	33	3	680
GeneFamily	Mitogen-activated protein kinase kinase kinase kinases	MAP4K5 MAP4K1	3.22e-05	5	33	2	655
GeneFamily	Sulfotransferases, cytosolic	SULT1A2 SULT1A1	2.90e-04	14	33	2	762
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	GALK2 ST3GAL5 MAP4K5 TRPC1 CKAP5 ARFGEF1 PARN IRS1 WDFY3 TRRAP	8.52e-06	856	54	10	M4500
Drug	MeA alpha C	SULT1A2 SULT1A1 CHRDL1 SLC38A6	2.00e-07	22	54	4	CID000062244
Drug	tryptophan pyrolysate	SULT1A2 SULT1A1 TRPC1 CHRDL1 SLC38A6	2.16e-07	56	54	5	CID005284475
Drug	Glu-P-2	SULT1A2 SULT1A1 CHRDL1 SLC38A6	6.42e-07	29	54	4	CID000049970
Drug	phenylhydroxylamine	SULT1A2 SULT1A1 GMPR SLC38A6	1.96e-06	38	54	4	CID000007518
Drug	5-hydroxymethylfurfural	SULT1A2 SULT1A1	5.52e-06	2	54	2	ctd:C008046
Drug	2,4-DNT	SULT1A2 SULT1A1 GMPR SLC38A6	7.03e-06	52	54	4	CID000008461
Drug	Cefepime hydrochloride [123171-59-5]; Down 200; 7.4uM; MCF7; HT_HG-U133A	MED16 MAP4K5 C15orf39 WDFY3 DBT TBC1D9	7.11e-06	197	54	6	6237_DN
Drug	MeIQx	SULT1A2 SULT1A1 CHRDL1 SLC38A6	8.81e-06	55	54	4	CID000062275
Drug	dimenhydrinate	SULT1A2 SULT1A1 PARN	1.00e-05	18	54	3	CID000010660
Drug	N-hydroxy-2-aminofluorene	SULT1A2 SULT1A1 SLC38A6	1.63e-05	21	54	3	CID000005895
Drug	5-hydroxy-3-methylindole	SULT1A2 SULT1A1	1.65e-05	3	54	2	CID000192734
Drug	AalphaC	SULT1A2 SULT1A1 CHRDL1	2.46e-05	24	54	3	CID000062805
Drug	2,4,6-trinitrotoluene	SULT1A2 SULT1A1 TRPC1 GMPR	3.03e-05	75	54	4	CID000008376
Drug	dimethylaminobenzoate	TBC1D9 ABCB4	3.30e-05	4	54	2	CID012241998
Drug	Chebi:32701	SULT1A2 SULT1A1	3.30e-05	4	54	2	CID005460855
Drug	AC1L1B9H	DBT ADCY8 TBC1D9 ABCB4	3.54e-05	78	54	4	CID000001341
Drug	DiMeIQx	SULT1A2 SULT1A1 SLC38A6	3.54e-05	27	54	3	CID000104739
Drug	N-hydroxy-AABP	SULT1A2 SULT1A1 SLC38A6	3.54e-05	27	54	3	CID000020527
Drug	N-hydroxy-4-aminobiphenyl	SULT1A2 SULT1A1 SLC38A6	3.96e-05	28	54	3	CID000081261
Drug	1,8-dinitropyrene	CHRDL1 GMPR SLC38A6	5.41e-05	31	54	3	CID000039185
Drug	TKPP	SULT1A2 SULT1A1	5.50e-05	5	54	2	CID000023740
Drug	AC1L2MCS	TBC1D9 ABCB4	5.50e-05	5	54	2	CID000023441
Drug	DCNP	SULT1A2 SULT1A1 GMPR	6.54e-05	33	54	3	CID000012066
Drug	dehydroacetic acid	SULT1A2 SULT1A1 SLC38A6	7.16e-05	34	54	3	CID000122903
Drug	chromium picolinate	SULT1A2 SULT1A1 GPR85	7.16e-05	34	54	3	CID000151932
Drug	DNOC	SULT1A2 SULT1A1 GMPR	7.82e-05	35	54	3	CID000010800
Drug	2-Sulfotrehalose	SULT1A2 SULT1A1	8.23e-05	6	54	2	CID000124677
Drug	N-hydroxy-2-acetylaminophenanthrene	SULT1A2 SULT1A1	8.23e-05	6	54	2	CID000017102
Drug	v 104	TBC1D9 ABCB4	8.23e-05	6	54	2	CID000107262
Drug	AC1L99H3	TBC1D9 ABCB4	8.23e-05	6	54	2	CID000440540
Drug	adenosine 3'-5'-diphosphate	SULT1A2 SULT1A1 XRN1 AASDHPPT	8.65e-05	98	54	4	CID000000073
Drug	Moroxidine hydrochloride [3160-91-6]; Down 200; 19.2uM; PC3; HT_HG-U133A	PPP2R5D MED16 CHRDL1 TOP6BL WDFY3	9.61e-05	194	54	5	6705_DN
Drug	Clofazimine [2030-63-9]; Down 200; 8.4uM; PC3; HT_HG-U133A	SPAM1 GALK2 CHRDL1 GMPR PIGO	9.61e-05	194	54	5	4682_DN
Drug	Biotin [58-85-5]; Down 200; 16.4uM; PC3; HT_HG-U133A	SPAM1 ST3GAL5 CHRDL1 GMPR PIGO	9.85e-05	195	54	5	6689_DN
Drug	Chlorambucil [305-03-3]; Down 200; 13.2uM; MCF7; HT_HG-U133A	SPAM1 MED16 TRPC1 GMPR TOP6BL	9.85e-05	195	54	5	4345_DN
Drug	Chicago sky blue 6B [2610-05-1]; Up 200; 4uM; MCF7; HT_HG-U133A	AMPD1 MED16 ANTXR1 BRINP1 WDFY3	9.85e-05	195	54	5	3266_UP
Drug	wortmannin from Penicillium funiculosum; Up 200; 0.01uM; PC3; HT_HG-U133A	AMPD1 MED16 AVIL CHRDL1 GMPR	9.85e-05	195	54	5	4467_UP
Drug	Trimeprazine tartrate [4330-99-8]; Down 200; 5.4uM; PC3; HT_HG-U133A	GALK2 MED16 MAP4K5 ANTXR1 DBT	1.01e-04	196	54	5	5881_DN
Drug	Racecadotril [81110-73-8]; Up 200; 10.4uM; MCF7; HT_HG-U133A	ST3GAL5 GMPR TOP6BL PIGO ABCB4	1.01e-04	196	54	5	2774_UP
Drug	Mesoridazine besylate [32672-69-8]; Down 200; 7.4uM; MCF7; HT_HG-U133A	PPP2R5D MED16 MAP4K5 ARFGEF1 PIGO	1.01e-04	196	54	5	7017_DN
Drug	Zuclopenthixol hydrochloride [633-59-0]; Down 200; 9.2uM; MCF7; HT_HG-U133A	SPAM1 MED16 PDCD11 WDFY3 PIGO	1.01e-04	196	54	5	7356_DN
Drug	(+,-)-Octopamine hydrochloride [770-05-8]; Up 200; 21uM; HL60; HT_HG-U133A	MED16 TRPC1 BRINP1 TBC1D9 ABCB4	1.03e-04	197	54	5	3112_UP
Drug	Sulfadiazine [68-35-9]; Down 200; 16uM; PC3; HT_HG-U133A	ST3GAL5 MED16 TRPC1 C15orf39 PIGO	1.03e-04	197	54	5	1810_DN
Drug	Dichlorphenamide [120-97-8]; Down 200; 13.2uM; PC3; HT_HG-U133A	SPAM1 ST3GAL5 CHRDL1 GMPR WDFY3	1.03e-04	197	54	5	6686_DN
Drug	PF-00539745-00 [351321-33-0]; Down 200; 10uM; PC3; HT_HG-U133A	MED16 MAP4K5 GPR85 GMPR PIGO	1.03e-04	197	54	5	5939_DN
Drug	Guanethidine sulfate [60-02-6]; Up 200; 13.4uM; PC3; HT_HG-U133A	PXMP4 AMPD1 SPAM1 ST3GAL5 TBC1D9	1.08e-04	199	54	5	5731_UP
Drug	AC1L577W	SULT1A2 SULT1A1	1.15e-04	7	54	2	CID000171279
Drug	dopamine-4-O-sulfate	SULT1A2 SULT1A1	1.15e-04	7	54	2	CID000123932
Drug	2-naphthylsulfate	SULT1A2 SULT1A1	1.15e-04	7	54	2	CID000074428
Drug	2-iodo-4-azidophenol	SULT1A2 SULT1A1	1.15e-04	7	54	2	CID003035977
Drug	N-acetyl-2-naphthylhydroxylamine	SULT1A2 SULT1A1	1.15e-04	7	54	2	CID000017272
Drug	luciferyl sulfate	SULT1A2 SULT1A1	1.15e-04	7	54	2	CID011953812
Drug	Phosphoadenosine Phosphosulfate	SULT1A2 SULT1A1	1.15e-04	7	54	2	ctd:D010724
Drug	2-AF	SULT1A2 SULT1A1 GMPR	1.26e-04	41	54	3	CID000005800
Drug	octopamine	SULT1A2 SULT1A1 DBT ADCY8	1.31e-04	109	54	4	CID000004581
Drug	N-hydroxy-PhIP	SULT1A2 SULT1A1 SLC38A6	1.46e-04	43	54	3	CID000104954
Drug	tBCEU	TBC1D9 ABCB4	1.53e-04	8	54	2	CID000164059
Drug	2-iodophenol	SULT1A2 SULT1A1	1.53e-04	8	54	2	CID000010784
Drug	dopamine 3-O-sulfate	SULT1A2 SULT1A1	1.53e-04	8	54	2	CID000122136
Drug	tri-n-butylmethylammonium	TBC1D9 ABCB4	1.53e-04	8	54	2	CID000036208
Drug	N-hydroxy-4-aminobiphenyl	SULT1A2 SULT1A1	1.53e-04	8	54	2	ctd:C014593
Drug	hydrocodone/acetaminophen	AMPD1 AVIL	1.53e-04	8	54	2	CID005748525
Drug	tXMP	TBC1D9 ABCB4	1.53e-04	8	54	2	CID003081384
Drug	6-anilino-2-thiouracil	SULT1A2 SULT1A1	1.53e-04	8	54	2	CID003037707
Drug	3-hydroxy-3-methyloxindole	SULT1A2 SULT1A1	1.97e-04	9	54	2	CID000151066
Drug	dichlorobiphenyl	CHRDL1 DBT	1.97e-04	9	54	2	CID000027959
Drug	So324	TBC1D9 ABCB4	1.97e-04	9	54	2	CID000462261
Drug	M977	SULT1A2 SULT1A1 CHRDL1	2.02e-04	48	54	3	CID000015419
Drug	sulfamethazine	SULT1A2 SULT1A1 SLC38A6	2.02e-04	48	54	3	CID000005327
Drug	N-hydroxy-2-acetylaminofluorene	SULT1A2 SULT1A1 SLC38A6	2.02e-04	48	54	3	CID000005896
Drug	PhIP-HCl	SULT1A2 SULT1A1 CHRDL1 SLC38A6	2.08e-04	123	54	4	CID000001530
Drug	Emd 51921	TBC1D9 ABCB4	2.45e-04	10	54	2	CID000164353
Drug	AC1NN9F1	TBC1D9 ABCB4	2.45e-04	10	54	2	CID000000410
Drug	Dolicholp	GALK2 PIGP ALG1	2.87e-04	54	54	3	CID000000680
Drug	DAPM	SULT1A2 SULT1A1 TRRAP SLC38A6	2.97e-04	135	54	4	CID000007577
Drug	2-amino-3-methyl-9H-pyrido(2,3-b)indole	SULT1A2 SULT1A1	3.00e-04	11	54	2	ctd:C017821
Drug	physcione	SULT1A1 ABCB4	3.00e-04	11	54	2	ctd:C008905
Drug	sultopride	SULT1A2 SULT1A1	3.00e-04	11	54	2	CID000005357
Drug	trequinsin	ADCY8 TBC1D9 ABCB4	3.55e-04	58	54	3	CID000005537
Drug	2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct	SULT1A2 SULT1A1	3.59e-04	12	54	2	ctd:C502239
Drug	2-aminoacetophenone	SULT1A2 SULT1A1	3.59e-04	12	54	2	CID000011952
Drug	2-nitrosopropane	SULT1A2 SULT1A1	3.59e-04	12	54	2	CID000079121
Drug	IC-1	TBC1D9 ABCB4	3.59e-04	12	54	2	CID000049829
Drug	aniline	SULT1A2 SULT1A1 GMPR SLC38A6	3.60e-04	142	54	4	CID000006115
Drug	AC1O4QIW	SULT1A2 SULT1A1 RXFP2	3.73e-04	59	54	3	CID006398478
Drug	4-hydroxybiphenyl	SULT1A2 SULT1A1 DBT	3.73e-04	59	54	3	CID000007103
Drug	acetaminophen glucuronide	SULT1A2 SULT1A1 ABCB4	3.73e-04	59	54	3	CID000083944
Drug	sulfallate	SULT1A2 SULT1A1	4.24e-04	13	54	2	CID000007216
Drug	S 16020-2	TBC1D9 ABCB4	4.24e-04	13	54	2	CID000177329
Drug	3-methyloxindole	SULT1A2 SULT1A1	4.24e-04	13	54	2	CID000150923
Drug	I mAb	TBC1D9 ABCB4	4.24e-04	13	54	2	CID003082777
Drug	EM-139	SULT1A2 SULT1A1	4.24e-04	13	54	2	CID000131427
Drug	tryptophan-P-1	TRPC1 CHRDL1 SLC38A6	4.32e-04	62	54	3	CID005232175
Disease	X-12707 measurement	SULT1A2 SULT1A1	2.14e-04	12	54	2	EFO_0800720
Disease	Colorectal Carcinoma	AMPD1 ARFGEF1 BRINP1 ABCA10 PIGO ADCY8 ABCB4	2.81e-04	702	54	7	C0009402
Disease	ascorbic acid 3-sulfate measurement	SULT1A2 SULT1A1	2.95e-04	14	54	2	EFO_0800173
Disease	leucine measurement	MAP4K5 IRS1 DBT	3.29e-04	73	54	3	EFO_0009770
Disease	Autosome Abnormalities	SULT1A2 SULT1A1	3.88e-04	16	54	2	C0004403
Disease	Chromosome Aberrations	SULT1A2 SULT1A1	3.88e-04	16	54	2	C0008625
Disease	Intrahepatic cholestasis of pregnancy	MAP4K5 ABCB4	3.88e-04	16	54	2	EFO_0009048
Disease	Cholecystitis	MAP4K5 ABCB4	5.51e-04	19	54	2	HP_0001082
Disease	Seizures	PIGP DBT PIGU TRRAP	6.86e-04	218	54	4	C0036572
Disease	corpus callosum central volume measurement	SLC9A4 PIGO	1.21e-03	28	54	2	EFO_0010296
Disease	Ischemic stroke, factor VII measurement	MAP4K5 PIGU	1.29e-03	29	54	2	EFO_0004619, HP_0002140
Disease	Intellectual Disability	PPP2R5D PIGP ST3GAL5 PIGU TRRAP	1.34e-03	447	54	5	C3714756
Disease	obese body mass index status	SULT1A1 ADCY8	1.67e-03	33	54	2	EFO_0007041
Disease	Global developmental delay	PIGP PIGU TRRAP	1.88e-03	133	54	3	C0557874
Disease	venous thromboembolism, factor VII measurement	MAP4K5 PIGU	2.22e-03	38	54	2	EFO_0004286, EFO_0004619
Disease	ciliopathy (implicated_via_orthology)	MAP4K5 MAP4K1	2.45e-03	40	54	2	DOID:0060340 (implicated_via_orthology)
Disease	lysophosphatidylcholine 20:3 measurement	MAP4K5 PARN	2.45e-03	40	54	2	EFO_0010362
Disease	nasopharyngeal neoplasm	IRS1 PIGU ADCY8	2.69e-03	151	54	3	EFO_0004252
Disease	autism spectrum disorder (implicated_via_orthology)	TRPC1 BRINP1 WDFY3	2.74e-03	152	54	3	DOID:0060041 (implicated_via_orthology)
Disease	reticulocyte count	MED16 MAP4K5 ANTXR1 GMPR IRS1 ADCY8 ABCB4	2.84e-03	1045	54	7	EFO_0007986
Disease	coffee consumption measurement, tea consumption measurement	MAP4K5 XRN1	2.96e-03	44	54	2	EFO_0006781, EFO_0010091
Disease	reticulocyte measurement	MED16 MAP4K5 ANTXR1 GMPR IRS1 ADCY8 ABCB4	2.96e-03	1053	54	7	EFO_0010700

Protein segments in the cluster

Peptide	Gene	Start	Entry
DKLRREHIKPFSLMF	ADCY8	681	P40145
IPEFFHIMKRKFTNK	AASDHPPT	141	Q9NRN7
EPRHFMAIFKGKLVI	AVIL	481	O75366
FFKETPLDLQHRLFM	ALG1	221	Q9BT22
HKFISPQLRMSFIVF	ANTXR1	71	Q9H6X2
HPLSRAFFKLEAMKQ	ABCA10	1481	Q8WWZ4
KSFMKRLPSNHFLTI	BRINP1	311	O60477
MRVNKLLFAAHLPVF	ADAM20	76	O43506
RFQKDFLRPFEHIMK	ARFGEF1	1231	Q9Y6D6
FALPLKEEHKMFLIR	PPP2R5D	311	Q14738
FRSKNFLPHFGKMLE	AMPD1	466	P23109
RSKLIEPFFNKLFLM	PARN	411	O95453
IPRKFMFEHRKFLSD	RADX	706	Q6NSI4
RGIKLSFMPFFLKAA	DBT	301	P11182
FRLMTPESKIRFVHK	ECHDC1	171	Q9NTX5
LRQMDKLPAIFFLFK	DDX60L	1101	Q5H9U9
HPRLLKLKEMFNSKF	GALK2	16	Q01415
KPKSMHKRFFVLRAA	IRS1	21	P35568
VCFVKRLKFPSVMHF	OOSP4B	96	A0A2R8Y4Y8
IKLKEHPIFFMFIQI	PIGU	306	Q9H490
KFPAITHLKFLARDM	MED16	276	Q9Y2X0
KLSAAHLFMLFERQP	ABCB4	1001	P21439
RILLDIHIFMKVFPK	CKAP5	1731	Q14008
PLMKKVFDIHLAFLK	DOCK11	1431	Q5JSL3
KRMFEELPHFKLVTR	CHRDL1	396	Q9BU40
RSKAPMSLFLLEVHF	BPIFB6	346	Q8NFQ5
IFFVHDRRKMKPVQF	GPR85	206	P60893
MGVLKFKHIFFRSFV	SPAM1	1	P38567
FVKLVRAKFPEHTIM	GMPR	141	P36959
IVFLFHRLSKAPGKM	PIGP	11	P57054
IMKNSFPRKTRLKHF	HELB	936	Q8NG08
QKFMLIKHFDFPLPS	MAP4K5	656	Q9Y4K4
FDVHPLRVLFLMTKS	MAP4K1	216	Q92918
LRIANFNHPLFFLMK	TAS2R40	121	P59535
FNHPLFFLMKRKIIV	TAS2R40	126	P59535
RKIIMVHPKVRFHFS	TOP6BL	131	Q8N6T0
LIHFPARKAVTMMFF	SLC38A6	346	Q8IZM9
IPMKSLHRGRKAFSF	SLC9A4	711	Q6AI14
RPKFAKTSMALLFEH	ST3GAL5	121	Q9UNP4
VFKHLFSLRLITMFF	RXFP2	6	Q8WXD0
RFHVLSKLLSFMAPI	AATF	516	Q9NY61
SVAFMFRKFKILRPA	C15orf39	646	Q6ZRI6
FGRIIHTPFMKFIIH	TRPC1	376	P48995
VIHLSLAPKRMKFFF	PDCD11	1821	Q14690
FLAQRKFKMLPLHEQ	TTLL11	716	Q8NHH1
HPAKKFVFDFMRVLI	WDFY3	1956	Q8IZQ1
HRAPIFMRVPFLEFK	SULT1A1	71	P50225
HRAPIFMRVPFLEFK	SULT1A2	71	P50226
FKEAIVKFHRLFGMP	TBC1D9	141	Q6ZT07
LFRIIKPRKVFFMAV	XRN1	71	Q8IZH2
TFKFMKRHTLERNPI	ZNF844	546	Q08AG5
RHLMVWKVFAPKFIF	PIGO	1036	Q8TEQ8
AKIRAPHALVMTFLF	PXMP4	41	Q9Y6I8
LRPHTKNVLSVMFRF	TRRAP	106	Q9Y4A5
MEVKHPRFFALFEKH	PPIP5K1	411	Q6PFW1
FPLEAITAFMDHKKL	ZNF296	121	Q8WUU4