Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	protein dephosphorylation	DUSP12 MTMR6 FCRL3 RCAN1 DUSP7 CTDP1 CDC25B ANKLE2	1.27e-05	256	87	8	GO:0006470
GeneOntologyBiologicalProcess	dephosphorylation	DUSP12 MTMR6 FCRL3 RCAN1 DUSP7 CTDP1 PPP1R17 CDC25B ANKLE2	1.58e-05	347	87	9	GO:0016311
GeneOntologyBiologicalProcess	negative regulation of organelle organization	EXOSC10 BRCA1 TLR2 DCP2 ARHGEF18 NUF2 ARHGEF2 PLEKHH2 SLX4	7.10e-05	421	87	9	GO:0010639
GeneOntologyCellularComponent	CKM complex	CDK8 CDK19	1.90e-04	5	92	2	GO:1990508
HumanPheno	Upslanted palpebral fissure	UBR1 LIG4 BRCA1 NFIA NFIX NARS1 HERC1 ANKLE2 CERT1 SLX4 TOE1	2.94e-06	333	32	11	HP:0000582
Domain	NfI_DNAbd_pre-N	NFIA NFIC NFIX	4.31e-07	4	90	3	PF10524
Domain	CTF_NFI	NFIA NFIC NFIX	4.31e-07	4	90	3	PF00859
Domain	CTF_NFI_1	NFIA NFIC NFIX	4.31e-07	4	90	3	PS00349
Domain	CTF/NFI	NFIA NFIC NFIX	4.31e-07	4	90	3	IPR000647
Domain	CTF_NFI_2	NFIA NFIC NFIX	4.31e-07	4	90	3	PS51080
Domain	CTF/NFI_DNA-bd_N	NFIA NFIC NFIX	4.31e-07	4	90	3	IPR019548
Domain	CTF/NFI_DNA-bd_CS	NFIA NFIC NFIX	4.31e-07	4	90	3	IPR019739
Domain	CTF/NFI_DNA-bd-dom	NFIA NFIC NFIX	4.31e-07	4	90	3	IPR020604
Domain	BRCT	LIG4 PARP4 BRCA1 CTDP1	1.85e-06	19	90	4	PF00533
Domain	BRCT	LIG4 PARP4 BRCA1 CTDP1	3.45e-06	22	90	4	SM00292
Domain	-	LIG4 PARP4 BRCA1 CTDP1	4.16e-06	23	90	4	3.40.50.10190
Domain	BRCT	LIG4 PARP4 BRCA1 CTDP1	6.95e-06	26	90	4	PS50172
Domain	BRCT_dom	LIG4 PARP4 BRCA1 CTDP1	9.45e-06	28	90	4	IPR001357
Domain	MAD_homology1_Dwarfin-type	NFIA NFIC NFIX	2.31e-05	12	90	3	IPR003619
Domain	DWA	NFIA NFIC NFIX	2.31e-05	12	90	3	SM00523
Domain	MH1	NFIA NFIC NFIX	2.31e-05	12	90	3	PF03165
Domain	ssDNA-bd_transcriptional_reg	NFIC NFIX	6.87e-05	3	90	2	IPR009044
Domain	Oest-rel_rcp	ESRRA ESRRG	6.87e-05	3	90	2	IPR027289
Domain	Oest_rcpt/oest-rel_rcp	ESRRA ESRRG	2.27e-04	5	90	2	IPR024178
Domain	Retinoid-X_rcpt/HNF4	ESRRA ESRRG	1.01e-03	10	90	2	IPR000003
Domain	DUF4599	SPATA31D4 SPATA31D3	1.47e-03	12	90	2	PF15371
Domain	DUF4599	SPATA31D4 SPATA31D3	1.47e-03	12	90	2	IPR027970
Domain	uDENN	DENND2A DENND1B	2.01e-03	14	90	2	SM00800
Domain	START	STARD9 CERT1	2.31e-03	15	90	2	PF01852
Domain	START_lipid-bd_dom	STARD9 CERT1	2.31e-03	15	90	2	IPR002913
Domain	uDENN	DENND2A DENND1B	2.31e-03	15	90	2	PF03456
Domain	START	STARD9 CERT1	2.31e-03	15	90	2	PS50848
Domain	UDENN	DENND2A DENND1B	2.64e-03	16	90	2	PS50946
Domain	DDENN	DENND2A DENND1B	2.64e-03	16	90	2	PS50947
Domain	DENN	DENND2A DENND1B	2.64e-03	16	90	2	SM00799
Domain	dDENN	DENND2A DENND1B	2.64e-03	16	90	2	SM00801
Domain	DENN	DENND2A DENND1B	2.64e-03	16	90	2	PF02141
Domain	dDENN_dom	DENND2A DENND1B	2.64e-03	16	90	2	IPR005112
Domain	uDENN_dom	DENND2A DENND1B	2.64e-03	16	90	2	IPR005113
Domain	dDENN	DENND2A DENND1B	2.64e-03	16	90	2	PF03455
Domain	DENN	DENND2A DENND1B	2.64e-03	16	90	2	PS50211
Domain	DENN_dom	DENND2A DENND1B	2.64e-03	16	90	2	IPR001194
Domain	Interferon_alpha/beta/delta	IFNA8 IFNA14	2.98e-03	17	90	2	IPR000471
Domain	Interferon	IFNA8 IFNA14	2.98e-03	17	90	2	PF00143
Domain	IFabd	IFNA8 IFNA14	2.98e-03	17	90	2	SM00076
Domain	INTERFERON_A_B_D	IFNA8 IFNA14	2.98e-03	17	90	2	PS00252
Domain	ZF_RING_2	UBR1 BRCA1 VPS41 RNF213 ZNF598 RNF17	3.18e-03	298	90	6	PS50089
Domain	RNaseH-like_dom	EXOSC10 THAP12 TOE1	4.51e-03	69	90	3	IPR012337
Domain	Znf_RING	UBR1 BRCA1 VPS41 RNF213 ZNF598 RNF17	4.93e-03	326	90	6	IPR001841
Domain	RHOD	DUSP7 CDC25B	4.98e-03	22	90	2	SM00450
Domain	RHODANESE_3	DUSP7 CDC25B	5.44e-03	23	90	2	PS50206
Domain	-	STARD9 CERT1	5.44e-03	23	90	2	3.30.530.20
Domain	START-like_dom	STARD9 CERT1	5.44e-03	23	90	2	IPR023393
Domain	Rhodanese-like_dom	DUSP7 CDC25B	5.92e-03	24	90	2	IPR001763
Domain	Rhodanese	DUSP7 CDC25B	5.92e-03	24	90	2	PF00581
Domain	-	DUSP7 CDC25B	5.92e-03	24	90	2	3.40.250.10
Domain	TYR_PHOSPHATASE_1	DUSP12 MTMR6 DUSP7	8.30e-03	86	90	3	PS00383
Domain	TYR_PHOSPHATASE_2	DUSP12 MTMR6 DUSP7	8.57e-03	87	90	3	PS50056
Pathway	REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION	GTF3A NFIA NFIC NFIX	4.13e-05	41	67	4	M739
Pathway	REACTOME_RSV_HOST_INTERACTIONS	CDK8 TLR2 CDK19 IFNA8 IFNA14	1.01e-04	98	67	5	M48247
Pathway	REACTOME_RNA_POLYMERASE_III_TRANSCRIPTION_TERMINATION	NFIA NFIC NFIX	1.70e-04	23	67	3	M1024
Pathway	REACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_PATHWAY	CDK8 TLR2 CDK19 IFNA8 IFNA14	2.61e-04	120	67	5	M48233
Pathway	REACTOME_INFECTION_WITH_MYCOBACTERIUM_TUBERCULOSIS	TLR2 RNF213 GSK3A	2.77e-04	27	67	3	M29816
Pubmed	Expression patterns of the four nuclear factor I genes during mouse embryogenesis indicate a potential role in development.	NFIA NFIC NFIX	7.15e-08	4	92	3	9056636
Pubmed	Nuclear factor one transcription factors as epigenetic regulators in cancer.	NFIA NFIC NFIX	7.15e-08	4	92	3	28076901
Pubmed	Transcription factor NF 1 expression in involuting mammary gland.	NFIA NFIC NFIX	7.15e-08	4	92	3	10959417
Pubmed	Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH.	NFIA NFIC NFIX	7.15e-08	4	92	3	7590749
Pubmed	High-throughput microarray detection of olfactory receptor gene expression in the mouse.	OR2M2 OR2M5 OR2M3	7.15e-08	4	92	3	15377787
Pubmed	Altered expression of the developmentally regulated NFI gene family during phorbol ester-induced differentiation of human leukemic cells.	NFIA NFIC NFIX	7.15e-08	4	92	3	9052991
Pubmed	Genomic organization, splice products and mouse chromosomal localization of genes for transcription factor Nuclear Factor One.	NFIA NFIC NFIX	7.15e-08	4	92	3	12568726
Pubmed	Regulation of the CYP3A4 and CYP3A7 promoters by members of the nuclear factor I transcription factor family.	NFIA NFIC NFIX	1.78e-07	5	92	3	19706729
Pubmed	Temporal control of a dendritogenesis-linked gene via REST-dependent regulation of nuclear factor I occupancy.	NFIA NFIC NFIX	3.56e-07	6	92	3	21270437
Pubmed	NFI in the development of the olfactory neuroepithelium and the regulation of olfactory marker protein gene expression.	NFIA NFIC NFIX	6.22e-07	7	92	3	10762365
Pubmed	TGF-β/NF1/Smad4-mediated suppression of ANT2 contributes to oxidative stress in cellular senescence.	NFIA NFIC NFIX	6.22e-07	7	92	3	25220407
Pubmed	Nfix regulates fetal-specific transcription in developing skeletal muscle.	NFIA NFIC NFIX	2.91e-06	11	92	3	20178747
Pubmed	BRCA1 is a component of the RNA polymerase II holoenzyme.	CDK8 BRCA1 CTDP1	3.87e-06	12	92	3	9159119
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	ARHGAP5 MTMR6 RCAN1 RNF213 COPG2 HID1 CRYBG3 ARHGEF2 HERC1 CDC25B ANKLE2 SDAD1 GSK3A	3.91e-06	1049	92	13	27880917
Pubmed	Nuclear factor I coordinates multiple phases of cerebellar granule cell development via regulation of cell adhesion molecules.	NFIA NFIC NFIX	5.03e-06	13	92	3	17553984
Pubmed	Estrogen-related receptor α (ERRα) and ERRγ are essential coordinators of cardiac metabolism and function.	ESRRA ESRRG	6.92e-06	2	92	2	25624346
Pubmed	Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.	CDK8 CDK19	6.92e-06	2	92	2	35181333
Pubmed	Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma.	ESRRA ESRRG	6.92e-06	2	92	2	17488637
Pubmed	Regulatory functions of the Mediator kinases CDK8 and CDK19.	CDK8 CDK19	6.92e-06	2	92	2	30585107
Pubmed	Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1.	BRCA1 EDC4	6.92e-06	2	92	2	29511213
Pubmed	HIV Transcription Is Independent of Mediator Kinases.	CDK8 CDK19	6.92e-06	2	92	2	31044597
Pubmed	Identification and characterization of estrogen receptor-related receptor alpha and gamma in human glioma and astrocytoma cells.	ESRRA ESRRG	6.92e-06	2	92	2	19822186
Pubmed	Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection.	CDK8 CDK19	6.92e-06	2	92	2	32560467
Pubmed	[Mechanisms of transcriptional regulation upon protein phosphorylation by mediator complexes].	CDK8 CDK19	6.92e-06	2	92	2	20408451
Pubmed	Isolation and functional characterization of a novel endogenous inverse agonist of estrogen related receptors (ERRs) from human pregnancy urine.	ESRRA ESRRG	6.92e-06	2	92	2	30954508
Pubmed	Interplay between estrogen-related receptor alpha (ERRalpha) and gamma (ERRgamma) on the regulation of ERRalpha gene expression.	ESRRA ESRRG	6.92e-06	2	92	2	17157980
Pubmed	Expression of estrogen receptor-related receptor isoforms and clinical significance in endometrial adenocarcinoma.	ESRRA ESRRG	6.92e-06	2	92	2	16681769
Pubmed	Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis.	ESRRA ESRRG	6.92e-06	2	92	2	17229846
Pubmed	Mediator kinase inhibition further activates super-enhancer-associated genes in AML.	CDK8 CDK19	6.92e-06	2	92	2	26416749
Pubmed	CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.	CDK8 CDK19	6.92e-06	2	92	2	28855340
Pubmed	Repression of osteoblast maturation by ERRα accounts for bone loss induced by estrogen deficiency.	ESRRA ESRRG	6.92e-06	2	92	2	23359549
Pubmed	Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.	CDK8 CDK19	6.92e-06	2	92	2	27678455
Pubmed	CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF.	CDK8 CDK19	6.92e-06	2	92	2	36006697
Pubmed	CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.	CDK8 CDK19	6.92e-06	2	92	2	37378433
Pubmed	Breast cancer risk and the DNA double-strand break end-joining capacity of nonhomologous end-joining genes are affected by BRCA1.	LIG4 BRCA1	6.92e-06	2	92	2	15256476
Pubmed	Estrogen receptor (ER) and ER-related receptor expression in normal and atrophic human vagina.	ESRRA ESRRG	6.92e-06	2	92	2	18328649
Pubmed	mRNA profiling identifies low levels of phosphatases dual‐specific phosphatase‐7 (DUSP7) and cell division cycle‐25B (CDC25B) in patients with early arthritis.	DUSP7 CDC25B	6.92e-06	2	92	2	28253537
Pubmed	Identification of target genes for the CDK subunits of the Mediator complex.	CDK8 CDK19	6.92e-06	2	92	2	22117896
Pubmed	Frontline Science: Estrogen-related receptor γ increases poly(I:C)-mediated type I IFN expression in mouse macrophages.	ESRRG IFNA8 IFNA14	7.96e-06	15	92	3	33615540
Pubmed	Exon structure of the nuclear factor I DNA-binding domain from C. elegans to mammals.	NFIA NFIC NFIX	9.78e-06	16	92	3	10087299
Pubmed	Bacterial ligand of TLR2 signals Stat activation via induction of IRF1/2 and interferon-alpha production.	TLR2 IFNA8 IFNA14	9.78e-06	16	92	3	18652890
Pubmed	Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88.	TLR2 IFNA8 IFNA14	1.68e-05	19	92	3	17942529
Pubmed	Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.	DUSP12 DUSP7	2.07e-05	3	92	2	8670865
Pubmed	Identification and characterization of protein interactions in the mammalian mRNA processing body using a novel two-hybrid assay.	DCP2 EDC4	2.07e-05	3	92	2	21672539
Pubmed	Mediator complex cooperatively regulates transcription of retinoic acid target genes with Polycomb Repressive Complex 2 during neuronal differentiation.	CDK8 CDK19	2.07e-05	3	92	2	26002960
Pubmed	A PPARα promoter variant impairs ERR-dependent transactivation and decreases mortality after acute coronary ischemia in patients with diabetes.	ESRRA ESRRG	2.07e-05	3	92	2	20838448
Pubmed	Estrogen-Related Receptors Mediate the Adaptive Response of Brown Adipose Tissue to Adrenergic Stimulation.	ESRRA ESRRG	2.07e-05	3	92	2	29888756
Pubmed	Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification.	NFIA NFIX	2.07e-05	3	92	2	31128945
Pubmed	The p53 tumor suppressor gene is regulated in vivo by nuclear factor 1-C2 in the mouse mammary gland during pregnancy.	NFIA NFIC	2.07e-05	3	92	2	12955085
Pubmed	Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues.	ESRRA ESRRG	2.07e-05	3	92	2	15598686
Pubmed	Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage.	BRCA1 SLX4	2.07e-05	3	92	2	34272385
Pubmed	New azaphilones and chlorinated phenolic glycosides from Chaetomium elatum with caspase-3 inhibitory activity.	EXOSC10 DCP2	2.07e-05	3	92	2	22890540
Pubmed	Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.	CDK8 CDK19	2.07e-05	3	92	2	28151579
Pubmed	PGC-1alpha induces dynamic protein interactions on the ERRalpha gene multi-hormone response element nucleosome in kidney cells.	ESRRA ESRRG	2.07e-05	3	92	2	18673300
Pubmed	CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP) gene transcription.	NFIA NFIC	2.07e-05	3	92	2	10085123
Pubmed	Estrogen-related receptor-gamma and peroxisome proliferator-activated receptor-gamma coactivator-1alpha regulate estrogen-related receptor-alpha gene expression via a conserved multi-hormone response element.	ESRRA ESRRG	2.07e-05	3	92	2	15821111
Pubmed	ERRα and ERRγ coordinate expression of genes associated with Alzheimer's disease, inhibiting DKK1 to suppress tau phosphorylation.	ESRRA ESRRG	2.07e-05	3	92	2	39231208
Pubmed	Kaempferol is an estrogen-related receptor alpha and gamma inverse agonist.	ESRRA ESRRG	2.07e-05	3	92	2	19171140
Pubmed	Human DNA ligase IV is able to use NAD+ as an alternative adenylation donor for DNA ends ligation.	LIG4 BRCA1	2.07e-05	3	92	2	30496552
Pubmed	NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing.	NFIC NFIX	2.07e-05	3	92	2	9099724
Pubmed	A protein interaction framework for human mRNA degradation.	EXOSC10 BRCA1 ESRRA DCP2 NARS1 FTL EDC4	3.92e-05	347	92	7	15231747
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	EXOC6 GPS1 DNAH2 UTP20 COPG2 EDC4 ARHGEF2 ZNF598 ANKLE2 TBL2 GSK3A	3.96e-05	942	92	11	31073040
Pubmed	Differential neuronal and glial expression of nuclear factor I proteins in the cerebral cortex of adult mice.	NFIA NFIX	4.14e-05	4	92	2	28295292
Pubmed	Gene regulatory networks controlling vertebrate retinal regeneration.	NFIA NFIX	4.14e-05	4	92	2	33004674
Pubmed	NFIA and GATA3 are crucial regulators of embryonic articular cartilage differentiation.	NFIA NFIX	4.14e-05	4	92	2	29247144
Pubmed	Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.	CDK8 CDK19	4.14e-05	4	92	2	29440396
Pubmed	The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa.	DCP2 EDC4	4.14e-05	4	92	2	20543818
Pubmed	Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development.	CDK8 CDK19	4.14e-05	4	92	2	32439758
Pubmed	HELB Is a Feedback Inhibitor of DNA End Resection.	LIG4 BRCA1	4.14e-05	4	92	2	26774285
Pubmed	ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency.	ESRRA ESRRG	4.14e-05	4	92	2	25865501
Pubmed	RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin.	NFIC NFIX	4.14e-05	4	92	2	12624117
Pubmed	Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha.	ESRRA ESRRG	4.14e-05	4	92	2	12181319
Pubmed	Target specificities of estrogen receptor-related receptors: analysis of binding sequences and identification of Rb1-inducible coiled-coil 1 (Rb1cc1) as a target gene.	ESRRA ESRRG	4.14e-05	4	92	2	18039682
Pubmed	Estrogen-related receptors alpha, beta and gamma expression and function is associated with transcriptional repressor EZH2 in breast carcinoma.	ESRRA ESRRG	4.14e-05	4	92	2	29940916
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PARP4 NFIA ARHGEF18 RNF213 PLEKHH2 MORC2 SLX4 UNC80	5.06e-05	493	92	8	15368895
Pubmed	Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.	BRCA1 NFIA NFIC ESRRA	5.35e-05	77	92	4	19505873
Pubmed	Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors.	ESRRA ESRRG	6.89e-05	5	92	2	18509053
Pubmed	Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif.	ESRRA ESRRG	6.89e-05	5	92	2	18063693
Pubmed	Growth factor signaling pathways modulate BRCA1 repression of estrogen receptor-alpha activity.	BRCA1 GSK3A	6.89e-05	5	92	2	17505062
Pubmed	Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation.	ESRRA ESRRG	6.89e-05	5	92	2	19690166
Pubmed	CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.	CDK8 CDK19	6.89e-05	5	92	2	36545778
Pubmed	Control of neurogenic competence in mammalian hypothalamic tanycytes.	NFIA NFIX	6.89e-05	5	92	2	34049878
Pubmed	The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1.	DCP2 EDC4	6.89e-05	5	92	2	24510189
Pubmed	The transcription factor gene Nfib is essential for both lung maturation and brain development.	NFIA NFIC NFIX	6.91e-05	30	92	3	15632069
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DENND1B STARD9 DCP2 FRYL CRYBG3 EDC4 ARHGEF2 CDC25B ZNF598 GSK3A	9.49e-05	861	92	10	36931259
Pubmed	The BRCT domain is a phospho-protein binding domain.	BRCA1 CTDP1	1.03e-04	6	92	2	14576433
Pubmed	Parkin degrades estrogen-related receptors to limit the expression of monoamine oxidases.	ESRRA ESRRG	1.03e-04	6	92	2	21177257
Pubmed	Peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells.	ESRRA ESRRG	1.03e-04	6	92	2	23836911
Pubmed	K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping.	DCP2 EDC4	1.03e-04	6	92	2	27315556
Pubmed	Absence of the transcription factor Nfib delays the formation of the basilar pontine and other mossy fiber nuclei.	NFIA NFIX	1.03e-04	6	92	2	19107796
Pubmed	Receptor-interacting protein 140 differentially regulates estrogen receptor-related receptor transactivation depending on target genes.	ESRRA ESRRG	1.03e-04	6	92	2	16439465
Pubmed	Involvement of p114-RhoGEF and Lfc in Wnt-3a- and dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells.	ARHGEF18 ARHGEF2	1.03e-04	6	92	2	20810787
Pubmed	DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa.	DCP2 EDC4	1.03e-04	6	92	2	19966221
Pubmed	Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects.	EXOSC10 DCP2	1.44e-04	7	92	2	26950371
Pubmed	Factors associated with the mammalian RNA polymerase II holoenzyme.	CDK8 BRCA1	1.44e-04	7	92	2	9443979
Pubmed	Mediator CDK subunits are platforms for interactions with various chromatin regulatory complexes.	CDK8 CDK19	1.44e-04	7	92	2	22668559
Pubmed	Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model.	TACC2 NUF2	1.92e-04	8	92	2	14602875
Pubmed	The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7.	CDK8 CDK19	1.92e-04	8	92	2	30695077
Pubmed	Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes.	CDK8 CDK19	1.92e-04	8	92	2	23749998
Pubmed	Sequence variant discovery in DNA repair genes from radiosensitive and radiotolerant prostate brachytherapy patients.	LIG4 BRCA1	1.92e-04	8	92	2	19638463
Cytoband	1q21-q22	DUSP12 FCRL3 ARHGEF2	1.38e-05	23	93	3	1q21-q22
Cytoband	Ensembl 112 genes in cytogenetic band chr13q12	CDK8 PARP4 MTMR6 GTF3A RNF17	1.19e-04	234	93	5	chr13q12
Cytoband	9q21.32	SPATA31D4 SPATA31D3	6.79e-04	19	93	2	9q21.32
Cytoband	13q12	CDK8 MTMR6	1.09e-03	24	93	2	13q12
Cytoband	17q25.3	CYBC1 GPS1 RNF213	1.16e-03	101	93	3	17q25.3
Cytoband	9p22	IFNA8 IFNA14	1.18e-03	25	93	2	9p22
Cytoband	1q44	OR2M2 OR2M5 OR2M3	1.48e-03	110	93	3	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2M2 OR2M5 OR2M3	2.29e-03	128	93	3	chr1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr17q25	CYBC1 GPS1 RNF213 HID1	3.59e-03	307	93	4	chr17q25
GeneFamily	Olfactory receptors, family 2	OR2M2 OR2M5 OR2M3 OR2Z1	6.49e-04	113	63	4	149
GeneFamily	StAR related lipid transfer domain containing	STARD9 CERT1	1.22e-03	15	63	2	759
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	BRCA1 SLX4	2.18e-03	20	63	2	548
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND2A DENND1B	3.40e-03	25	63	2	504
GeneFamily	Cyclin dependent kinases	CDK8 CDK19	3.68e-03	26	63	2	496
GeneFamily	Interferons	IFNA8 IFNA14	5.54e-03	32	63	2	598
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF18 ARHGEF2 PLEKHH2 CERT1	5.77e-03	206	63	4	682
GeneFamily	Cyclins\|Mediator complex	CDK8 CDK19	5.89e-03	33	63	2	1061
Coexpression	ONGUSAHA_BRCA1_TARGETS_DN	CDK8 DUSP12 ARHGAP5	6.33e-06	11	90	3	MM881
Coexpression	ONGUSAHA_BRCA1_TARGETS_DN	CDK8 DUSP12 ARHGAP5	6.33e-06	11	90	3	M2068
Coexpression	DING_LUNG_CANCER_EXPRESSION_BY_COPY_NUMBER	CDK8 MTMR6 GTF3A ANKRD10 VPS41	2.48e-05	100	90	5	M14670
Coexpression	GSE40685_NAIVE_CD4_TCELL_VS_TREG_UP	RCAN1 PPIL6 OR2M3 CCNYL3 MORC2 THAP12	6.33e-05	198	90	6	M9305
Coexpression	GSE14308_TH2_VS_NATURAL_TREG_DN	UBR1 CLCN2 ACTR10 ZNF598 ANKLE2 GSK3A	6.51e-05	199	90	6	M3369
Coexpression	GSE17721_CTRL_VS_CPG_12H_BMDC_UP	UBR1 ANKRD10 GPR87 FRYL NUF2 CDC25B	6.69e-05	200	90	6	M3769
Coexpression	GSE17721_CTRL_VS_GARDIQUIMOD_6H_BMDC_UP	ABHD15 HLA-DMA ANKRD10 DUSP7 NUF2 CDC25B	6.69e-05	200	90	6	M3785
Coexpression	GSE15735_2H_VS_12H_HDAC_INHIBITOR_TREATED_CD4_TCELL_DN	BRCA1 RCAN1 STARD9 CRYBG3 ARHGEF2 PCOLCE	6.69e-05	200	90	6	M7162
Disease	developmental and epileptic encephalopathy 87 (implicated_via_orthology)	CDK8 CDK19	8.01e-06	2	84	2	DOID:0112221 (implicated_via_orthology)
Disease	acylcarnitine measurement	NFIA CDK19 NARS1 HERC1	4.84e-04	127	84	4	EFO_0005059
Disease	MYELODYSPLASTIC SYNDROME	BRCA1 TLR2 SLX4	9.35e-04	67	84	3	C3463824
Disease	Fanconi Anemia	BRCA1 SLX4	2.30e-03	25	84	2	C0015625
Disease	Acute monocytic leukemia	BRCA1 SLX4	2.49e-03	26	84	2	C0023465
Disease	azoospermia (implicated_via_orthology)	ESRRA ESRRG	2.68e-03	27	84	2	DOID:14227 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SPRAHFSVLETCFDK	NAIP	926	Q13075
LFSHRILSRDECIDP	CTDP1	266	Q9Y5B0
CHTVPDIAFFSLLLF	SLC4A9	621	Q96Q91
LFPCADDLLETHSHF	ARHGEF18	491	Q6ZSZ5
HTRCSAFPLEQEADL	ANKLE2	671	Q86XL3
SEELLSLRFPLHRAC	ANKRD10	16	Q9NXR5
GCIFAELLTSEPIFH	CDK19	221	Q9BWU1
ELLTSEPIFHCRQED	CDK19	226	Q9BWU1
EPSISLFALEHCEGR	CRYBG3	2751	Q68DQ2
PCVDELSDIHTRFLS	ARHGEF2	281	Q92974
LCSRFILHIPSEERD	DCP2	16	Q8IU60
LCPSHFRETLTRVLF	ACTR10	96	Q9NZ32
SRSLREFEEALFCHT	ABHD15	311	Q6UXT9
CLTQDEFHPFIEALL	NFIA	6	Q12857
SATIACHLDPRVFVD	RCAN1	66	P53805
DLFHCVSFTLPRISA	PZP	81	P20742
SLSFRVFDLELHPAC	PCOLCE	76	Q15113
CFSSISEFLLTHPVL	EDC4	446	Q6P2E9
LSKAVITPHDFDECR	CERT1	71	Q9Y5P4
ITPHDFDECRFDISV	CERT1	76	Q9Y5P4
TAPFCQALLEELEHF	OGFOD2	146	Q6N063
RISPFSCLKDRHDFE	IFNA14	46	P01570
CLTQDEFHPFIEALL	NFIX	6	Q14938
PLSGFSARCLEDEHL	MTMR6	206	Q9Y217
RTDPHLCDFLETHFL	FTL	121	P02792
RDRFLFNPSACLDEH	HERC1	4561	Q15751
SREIAHFFCEFPSLL	OR2M2	171	Q96R28
SREIAHFFCDFPSLL	OR2M3	171	Q8NG83
SREIAHFFCDFPSLL	OR2M5	171	A3KFT3
SRIVDHFFCEVPALL	OR2Z1	171	Q8NG97
HLDSFLPICRVNDFE	NUF2	91	Q9BZD4
LLASFDHCDFPELLS	GPS1	271	Q13098
VAEHCLPSLLRTLFD	FRYL	66	O94915
VILIFHCEFSSERGP	CDC25B	481	P30305
SRDSRDCPFLISSHF	PARP4	176	Q9UKK3
LEPLGLHCTFIDDFT	PADI3	621	Q9ULW8
HDFVFLDICIDSSPI	PPIL6	141	Q8IXY8
CTLPFVLHSLRDTSD	GPR35	71	Q9HC97
LRAHSSYCTDPDLVL	EXOC6	376	Q8TAG9
CRIPFTFSHLDRLLD	GPR87	271	Q9BY21
LFTDDPSGRDLEHCL	PLEKHH2	1166	Q8IVE3
ELISCDLERIPHSIF	LRRC8B	591	Q6P9F7
TCLFLSRTFHEEEGI	MORC2	126	Q9Y6X9
EVCSFFHRSPQLLLE	THAP12	386	O43422
PDSFLEHLTSLCFLN	LRRC32	331	Q14392
LSSEDEELPCFQHLL	BRCA1	1216	P38398
TCFLLHPEDSTLERF	CCNYL3	271	P0C7X3
TPCHFISSLDELVEL	EXOSC10	286	Q01780
RLSPLEACAHSFFDE	GSK3A	391	P49840
ASHVPFADLCSTLER	LIG4	11	P49917
CRPLDSRLEHVDFES	DENND2A	731	Q9ULE3
QAARSCPELHSLFLD	FBXL8	156	Q96CD0
LCLPESFSLHYEEEL	ESRRG	6	P62508
EPFTDTHYLSLTRDC	GCNT3	96	O95395
LITSFLELHCLESPT	CYBC1	156	Q9BQA9
PSDIFSCIVTHEIDR	HLA-DMA	196	P28067
SLLLLDCRPHELFES	DUSP7	71	Q16829
GHESPLFDFIESCLR	COPG2	246	Q9UBF2
DLLELHCESLRGSFP	FCRL3	491	Q96P31
RISPFSCLKDRHDFE	IFNA8	46	P32881
GCIFAELLTSEPIFH	CDK8	221	P49336
ELLTSEPIFHCRQED	CDK8	226	P49336
EPITFCEESFVKHRS	DENND1B	351	Q6P3S1
FSTISVFCHLPDILT	DNAH2	901	Q9P225
PETDLLSHLDRCVAF	DUSP12	86	Q9UNI6
HLPAVATLCDLFDRE	ESRRA	221	P11474
TFFECLQESLLDLHT	UTP20	291	O75691
THVEAECPFLTFDDL	NARS1	336	O43776
DLLFCPDFTVQSHRR	HID1	151	Q8IV36
IDHCAPLLFTFVLAT	PTCHD4	726	Q6ZW05
LSPDSHCLDIDLNFI	SPATA31D4	16	Q6ZUB0
SVDLILSPFLDSHSC	ARHGAP5	791	Q13017
SSLLELFFELFRCHD	SDAD1	116	Q9NVU7
LLSRTEFCTAPLHQD	STARD9	2316	Q9P2P6
LCLTQDEFHPFIEAL	NFIC	6	P08651
RLLDFLDTHCITFTT	SLX4	1796	Q8IY92
RDVPHVALSCTFRDL	CLCN2	586	P51788
FCNRSSHLDPSDILE	RNF17	451	Q9BXT8
DPRCSHLDDLSDQFI	PPP1R17	21	O96001
FSRLLTSHDCEILES	RNF213	3321	Q63HN8
LSPDSHCLDIDLNFI	SPATA31D3	16	P0C874
DSETLSLDCDHRLFF	LINC02912	86	Q8N9X5
SLDCDHRLFFSLPFT	LINC02912	91	Q8N9X5
CLIEDPSTVLRHFLE	UNC80	1881	Q8N2C7
TERCKDLNTFLHEPF	RNASE8	61	Q8TDE3
PLEDSLFLNHSERLC	TEX43	76	Q6ZNM6
FLFSCDASHPDTLRI	TERB2	36	Q8NHR7
SEDTPCLLSIDLFHV	UBR1	1391	Q8IWV7
LAELLTPEECGHFRS	TMDD1	36	P0DPE3
TDDLEFLRACHLPRS	TACC2	301	O95359
FLRDSTHCPLEKALE	VPS41	631	P49754
PHFDSRSVIFELDSC	TPGS2	136	Q68CL5
ELLSAHTDFCNREKP	ZNF598	826	Q86UK7
HILSFHEESRPFVCE	GTF3A	266	Q92664
CLELRDTDLDTFHFS	TLR2	226	O60603
ETLPLHLCAITSFDV	WDR87	561	Q6ZQQ6
LDHATLVRFSPDCRA	TBL2	136	Q9Y4P3
HLPESLGTFTADLCE	TOE1	206	Q96GM8