Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
HumanPhenoRecurrent myoglobinuria

OBSCN HADHB

3.39e-05772HP:0003652
DomainTUDOR

SND1 ALG13

4.28e-0423252PS50304
DomainTudor

SND1 ALG13

7.31e-0430252IPR002999
Pubmed

Sequence diversity and genomic organization of vomeronasal receptor genes in the mouse.

VN1R5 HADHB

1.49e-06325211116090
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

OBSCN PDCD11 SND1 NUP210

1.59e-0521425422199357
Pubmed

Signalling through the type 1 insulin-like growth factor receptor (IGF1R) interacts with canonical Wnt signalling to promote neural proliferation in developing brain.

TCF7L2 WNT7A

5.92e-051625222625652
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

OBSCN ARFGEF3 TCF7L2 PCGF3 WWP2 ANKAR NUP210

6.33e-05148925728611215
Pubmed

Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression.

TCF7L2 WNT7A

8.42e-051925220219685
Pubmed

Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins.

MAN2A2 ALG13

1.47e-04252522283726
Pubmed

Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.

PDCD11 HADHB SND1

1.50e-0414425335681168
Pubmed

Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system.

MAN2A2 ALG13

1.60e-04262528218172
Pubmed

Non-canonical Wnt Signaling through Ryk Regulates the Generation of Somatostatin- and Parvalbumin-Expressing Cortical Interneurons.

TCF7L2 WNT7A

1.72e-042725231257105
Pubmed

Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development.

TCF7L2 WNT7A

2.58e-043325227414999
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

PDCD11 TCF7L2 CDK12 NUP210

2.99e-0445725432344865
Pubmed

Integrated analysis of Wnt signalling system component gene expression.

TCF7L2 WNT7A

3.25e-043725235831952
Pubmed

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.

TCF7L2 WNT7A

3.25e-043725215342465
Pubmed

Tissue-specific requirements of beta-catenin in external genitalia development.

TCF7L2 WNT7A

3.43e-043825218635608
Pubmed

Distinct requirements for cranial ectoderm and mesenchyme-derived wnts in specification and differentiation of osteoblast and dermal progenitors.

TCF7L2 WNT7A

3.62e-043925224586192
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

ARFGEF3 PDCD11 TCF7L2 HADHB SND1 NUP210

4.48e-04144025630833792
Pubmed

Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein.

MAN2A2 ALG13

5.04e-04462522649653
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PDCD11 KBTBD2 CDK12 ACAP3

5.19e-0452925414621295
Pubmed

Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination.

TCF7L2 WNT7A

5.26e-044725216678101
Pubmed

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.

PDCD11 VN1R5 HADHB SND1 CDK12

5.60e-0497125533306668
Pubmed

WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth.

TCF7L2 WNT7A

5.95e-045025218351662
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

OBSCN HADHB CDK12 ANKAR

6.60e-0456425421565611
GeneFamilyTudor domain containing

SND1 ALG13

6.82e-0437192780
GeneFamilyBasic leucine zipper proteins|BTB domain containing

ZBTB38 KBTBD2

8.58e-03134192861
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_2|356C / Donor, Lineage, Cell class and subclass (all cells)

TNFRSF9 HADHB ADAM12 ANKAR

2.81e-061782548b939659f713eea50a1a6e28b571f680ca0b4c12
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

TNFRSF9 HADHB ADAM12 ANKAR

3.27e-06185254e06a784a297f357f3f8e761c24fa70722048ab42
ToppCellICU-SEP-Lymphocyte-T_NK-Treg|ICU-SEP / Disease, Lineage and Cell Type

OBSCN TNFRSF9 ADAM12

7.16e-05145253ee99b58462f955b96d036aa67e343db047d66f64
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8|TCGA-Bladder / Sample_Type by Project: Shred V9

ARFGEF3 HADHB PCGF3

7.76e-0514925389705865e94360c1288ee98c5a6b381f3c6242b3
ToppCellMS-CD4-antiviral_CD4|MS / Condition, Cell_class and T cell subcluster

ADCY10 LANCL3 DRAP1

8.23e-05152253b1eba2d5a6da3eeb83d40a92976e3e8751ed18ee
ToppCellClub_cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

ARFGEF3 LANCL3 WNT7A

8.39e-0515325377030b0e033f3635b1bbe7552a28c074ea7bb106
ToppCell(7)_MNP-(7)_DC_activated|(7)_MNP / Spleen cell shreds - cell class (v1) and cell subclass (v1)

ADCY10 TNFRSF9 ADAM12

1.15e-041702534ab495b38a071fa8207331df2ce0d78a2dcd034e
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCF7L2 ADAM12 WWP2

1.17e-04171253a474aaed3ca4cacb0ab565c35f25d92a10f531b7
ToppCelldroplet-Spleen-SPLEEN-30m-Myeloid-macrophage_dendritic_cell_progenitor|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARFGEF3 TCF7L2 ADAM12

1.19e-0417225330916a902c151907745756d14327e24adc34afef
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TNFRSF9 HADHB ADAM12

1.43e-04183253f142b320023eef00b48d4820c46214c9794d37e7
ToppCell(1)_T_cells-(1)_T_regulatory|(1)_T_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

TNFRSF9 ZBTB38 ADAM12

1.45e-041842533cbf81757653652441843d85cb7ec1dcf25ca1b0
ToppCellILEUM-non-inflamed-(1)_T_cell-(1)_Tregs|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TNFRSF9 ZBTB38 ADAM12

1.59e-04190253f69a4733b5d1542ab4d0eb44856f2c5c34c18b9e
ToppCellILEUM-non-inflamed-(1)_Tregs|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TNFRSF9 ZBTB38 ADAM12

1.62e-04191253e065d16a1f88c91dec576d248a318534ceab1cb2
ToppCellILEUM-inflamed-(1)_Tregs|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TNFRSF9 ZBTB38 ADAM12

1.64e-041922531fe3417dfd1cf1758fd82c9ac13dbd88bdf0b548
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-T_cells-Treg|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNFRSF9 ZBTB38 ADAM12

1.64e-04192253b7e08cadb50f66c2efdde45e0fa8bab29367269b
ToppCelldistal-Hematologic-Basophil/Mast_2-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TNFRSF9 MAN2A2 ADAM12

1.67e-04193253f22d0a2ea6bbdd625909ccb6a89aca89ab670306
ToppCelldistal-Hematologic-Basophil/Mast_2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TNFRSF9 MAN2A2 ADAM12

1.67e-04193253dcdc1498726c68bf590bf84cb81e5f7fb7ba4d78
ToppCelldistal-3-Hematologic-Basophil/Mast_2|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TNFRSF9 MAN2A2 ADAM12

1.67e-0419325323c6c798525dad43eff792727902ea562bf373be
ToppCell3'_v3-blood-Lymphocytic_T_CD4-Tregs|blood / Manually curated celltypes from each tissue

TNFRSF9 ZBTB38 ADAM12

1.67e-041932532ffe44edf2b02d11a7c10513692eb697a10f911e
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARFGEF3 DRAP1 ADAM12

1.69e-04194253490645bfe9ed3dac03c191c7094df01c780b377e
ToppCellILEUM-inflamed-(1)_T_cell-(1)_Tregs|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TNFRSF9 ZBTB38 ADAM12

1.69e-041942530396457834bbfed8d0b9b2ddaaecd9f28e1d56ed
ToppCellSepsis-ICU-SEP-Lymphocyte-T/NK-Treg|ICU-SEP / Disease, condition lineage and cell class

OBSCN TNFRSF9 ADAM12

1.77e-04197253c3ee2d522fbfe67069ddba2d1abfc4f5ca230c26
Diseasecreatinine measurement

OBSCN TCF7L2 KBTBD2 SND1 CDK12 WNT7A

1.16e-04995246EFO_0004518
Diseasecreatinine measurement, glomerular filtration rate

KBTBD2 CDK12 WNT7A

1.16e-04117243EFO_0004518, EFO_0005208
Diseasebirth weight, parental genotype effect measurement

ZBTB38 TCF7L2 SND1

4.96e-04192243EFO_0004344, EFO_0005939
Diseaseschizophrenia, type 2 diabetes mellitus

TCF7L2 CDK12

5.61e-0443242MONDO_0005090, MONDO_0005148
Diseaseinsulin measurement

CNBD1 TCF7L2 WWP2

1.29e-03267243EFO_0004467
Diseasecortical thickness

CNBD1 TCF7L2 SND1 ADAM12 WNT7A

1.77e-031113245EFO_0004840
DiseaseNeurodevelopmental Disorders

TCF7L2 ALG13

2.59e-0393242C1535926
Diseasegrip strength measurement

ZBTB38 TCF7L2 WWP2

2.78e-03350243EFO_0006941
DiseaseHypermetropia

ZBTB38 CDK12

3.17e-03103242HP_0000540
Diseaseforced expiratory volume

ZBTB38 CDK12 WWP2 WNT7A

3.52e-03789244EFO_0004314
Diseasecortical surface area measurement

CNBD1 TCF7L2 SND1 ADAM12 WNT7A

4.02e-031345245EFO_0010736
Diseaseloneliness measurement

TCF7L2 ADAM12

4.55e-03124242EFO_0007865
Diseasewaist circumference

ZBTB38 TCF7L2 WWP2

4.92e-03429243EFO_0004342
Diseaseovarian neoplasm

CDK12 WNT7A

5.29e-03134242C0919267
DiseaseMalignant neoplasm of ovary

CDK12 WNT7A

5.52e-03137242C1140680
Diseasetotal blood protein measurement

ZBTB38 TCF7L2 SND1

5.59e-03449243EFO_0004536
Diseaseage at onset, Myopia

ZBTB38 TCF7L2

6.58e-03150242EFO_0004847, HP_0000545
Diseasenasopharyngeal neoplasm

ADAM12 CDK12

6.67e-03151242EFO_0004252
DiseaseColonic Neoplasms

TNFRSF9 TCF7L2

6.75e-03152242C0009375
Diseaseworry measurement

TCF7L2 SND1

6.93e-03154242EFO_0009589
DiseaseMalignant tumor of colon

TNFRSF9 TCF7L2

7.37e-03159242C0007102

Protein segments in the cluster

PeptideGeneStartEntry
LPYFNTMKPKKQYRR

CDK12

966

Q9NYV4
NPSKMPFPYKVLKAL

ALG13

446

Q9NP73
KYVEKKFLRKAPMAP

ACAP3

511

Q96P50
PMKSATNRYKLFPAK

ADAM12

156

O43184
NLPAYFFKELPKKVM

ADCY10

436

Q96PN6
LEQMAKLKPAFIKPY

HADHB

286

P55084
MPSKKKKYNARFPPA

DRAP1

1

Q14919
FKKAPLLLHYRPKMD

PCGF3

226

Q3KNV8
KKMKVPYLSSLLQPF

ANKAR

331

Q7Z5J8
KKPFLAKYFPFMDLK

NUP210

1006

Q8TEM1
VQGLYKSMPKFFKPR

KBTBD2

246

Q8IY47
QYAIKKRKPFPLMYS

LANCL3

211

Q6ZV70
KYLPFEFMIFRKVPK

OBSCN

7316

Q5VST9
LLAKIYKMPLKPIFL

ARFGEF3

1401

Q5TH69
RYLKKLPLQANFYPM

MAN2A2

911

P49641
KNKKLRPLYDIPYMF

SND1

386

Q7KZF4
FMKQYPKVFLHQKPR

CNBD1

66

Q8NA66
LAPKRMKFFFKRYLD

PDCD11

1826

Q14690
FTLPFYKRMLNKRPT

WWP2

626

O00308
KKPHIKKPLNAFMLY

TCF7L2

346

Q9NQB0
GRKKLLYIFKQPFMR

TNFRSF9

216

Q07011
FKYLSPPKLMLKFNR

VN1R5

336

Q7Z5H4
FLKIKKPLSYRKPMD

WNT7A

251

O00755
YRLLPMKCKRAPYKS

ZBTB38

566

Q8NAP3
CNRKMKPPYLKELYV

LRRCC1

376

Q9C099