Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenodecreased glycogen level

FOXO1 NCOR1 IRS2

3.37e-0565143MP:0005439
PathwayWP_FOXA2_PATHWAY

FOXO1 IRS2

1.15e-0421112M42579
PathwayWP_ADIPOGENESIS

FOXO1 NCOR1 IRS2

1.23e-04131113M39505
PathwayWP_TRANSCRIPTION_FACTOR_REGULATION_IN_ADIPOGENESIS

FOXO1 IRS2

1.27e-0422112M39414
PathwayWP_ADIPOGENESIS_GENES

FOXO1 NCOR1 IRS2

1.40e-04137113MM15970
PathwayWP_IL7_SIGNALING_PATHWAY

FOXO1 IRS2

4.91e-0443112MM15864
PathwaySIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES

FOXO1 IRS2

6.91e-0451112M7955
Pubmed

Hyaluronan fragments/CD44 mediate oxidative stress-induced MUC5B up-regulation in airway epithelium.

CD44 MUC5B

2.83e-07219218757307
Pubmed

The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling.

FOXO1 IRS2

2.83e-07219216916938
Pubmed

Tamoxifen reduces fat mass by boosting reactive oxygen species.

FOXO1 IRS2

8.48e-07319225569103
Pubmed

Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation.

FOXO1 IRS2

8.48e-07319218590693
Pubmed

IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action.

FOXO1 IRS2

1.70e-06419222560222
Pubmed

Foxo1 integrates insulin signaling with mitochondrial function in the liver.

FOXO1 IRS2

1.70e-06419219838201
Pubmed

FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance.

FOXO1 IRS2

1.70e-06419233761350
Pubmed

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

FOXO1 IRS2

1.70e-06419212219087
Pubmed

Hepatic p38α MAPK controls gluconeogenesis via FOXO1 phosphorylation at S273 during glucagon signalling in mice.

FOXO1 IRS2

2.82e-06519237202506
Pubmed

Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1.

FOXO1 IRS2

2.82e-06519221081708
Pubmed

Inactivating hepatic follistatin alleviates hyperglycemia.

FOXO1 IRS2

4.24e-06619229867232
Pubmed

FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction.

FOXO1 IRS2

5.93e-06719216154098
Pubmed

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.

FOXO1 IRS2

5.93e-06719212488434
Pubmed

FOXO1-mediated activation of Akt plays a critical role in vascular homeostasis.

FOXO1 IRS2

2.56e-051419224874427
Pubmed

Loss of SET reveals both the p53-dependent and the p53-independent functions in vivo.

FOXO1 IRS2

7.10e-052319230858352
Pubmed

The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice.

CD44 NCOR1

1.14e-042919228364022
Pubmed

FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.

NFATC3 NCOR1 CLASP2

1.31e-0418319336129980
Pubmed

Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.

FOXO1 NCOR1 IRS2

3.27e-0425019318660489
Cytoband12q13.12

FAM186B TROAP

1.13e-043819212q13.12
Cytoband11p13

CD44 C11orf91

2.47e-045619211p13
CytobandEnsembl 112 genes in cytogenetic band chr11p13

CD44 C11orf91

3.32e-0465192chr11p13
CytobandEnsembl 112 genes in cytogenetic band chr3p22

ZBTB47 CLASP2

2.61e-03184192chr3p22
CytobandEnsembl 112 genes in cytogenetic band chr12q13

FAM186B TROAP

1.31e-02423192chr12q13
CoexpressionGSE2935_UV_INACTIVATED_VS_LIVE_SENDAI_VIRUS_INF_MACROPHAGE_UP

FOXO1 TMEM108 CLASP2 IRS2

6.28e-06171194M6316
CoexpressionGSE3565_CTRL_VS_LPS_INJECTED_DUSP1_KO_SPLENOCYTES_DN

FOXO1 TMEM108 CLASP2 IRS2

6.28e-06171194M6321
CoexpressionGSE19941_IL10_KO_VS_IL10_KO_AND_NFKBP50_KO_LPS_AND_IL10_STIM_MACROPHAGE_UP

NCOR1 CLASP2 AHRR ZFC3H1

1.14e-05199194M8115
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SYN3 FOXO1 TMEM108 IRS2

1.23e-06194194e93de9428c986b8943fc169258847c650cfab0e5
ToppCellE12.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SYN3 FOXO1 REPS1

5.09e-051721933b9be685fcd1634498a603b692f5ac6ddd0de176
ToppCellfacs-SCAT-Fat-3m-Lymphocytic-B_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFATC3 TMEM108 IRS2

6.42e-05186193d5d990d8b6ccd8ca8fe7d0d7dedbe2359ae7b582
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Proximal_secretory_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

TROAP C5orf63 MUC5B

7.16e-051931930ef076417ffe2dd1cbc2c3d1e35c7f8522af143b
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

SYN3 FOXO1 TMEM108

7.16e-05193193b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXO1 TMEM108 IRS2

7.27e-051941933a1f95639d5f239f001bd67d4213e8938e7f299d
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXO1 TMEM108 IRS2

7.27e-0519419311709704079f24a730476572dc2f01e9d2226e2c
ToppCellIPF-Endothelial-VE_Capillary_B|Endothelial / Disease state, Lineage and Cell class

SYN3 CD44 TMEM108

7.49e-051961938f0f72ead06abe02b575e443552eacc2151077ef
ToppCellT_cells-Treg_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

CD44 FOXO1 IRS2

7.61e-05197193ec9398ae3577f61d6b1e6aba50ef4261aaaa7610
ToppCell(5)_Fibroblasts-(5)_Fibroblast-G|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

CD44 TMEM108 IRS2

7.61e-05197193a21a710c824f9e5c7ef1674168d1ce5aef85bd35
ToppCell(1)_T_cell-(11)_Activated_CD4_T|(1)_T_cell / shred on Cell_type and subtype

CD44 IRS2 GCSAM

7.72e-051981934b9ad91342f622c63e476d4f6a0ae5bf282a7ef5
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4|GI_small-bowel / Manually curated celltypes from each tissue

CD44 FOXO1 IRS2

7.72e-051981936333e46cd1ccf5841ce15aea98a4b2f5e3ae4675
ToppCell343B-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

CD44 TMEM108 IRS2

7.84e-05199193212e89d097753790061310373a1fafba773488b6
ToppCell343B-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

CD44 TMEM108 IRS2

7.84e-0519919314b676aa289c0578a37be32cec3ea285c79d97cc
DrugChlorpromazine hydrochloride [69-09-0]; Up 200; 11.2uM; MCF7; HT_HG-U133A

SYN3 CD44 NFATC3 IRS2

1.58e-051881945493_UP
DrugTicarcillin sodium [4697-14-7]; Down 200; 9.4uM; MCF7; HT_HG-U133A

CD44 FOXO1 NFATC3 TROAP

1.90e-051971947185_DN
DiseaseAcute Myeloid Leukemia, M1

CD44 FOXO1

2.90e-03125192C0026998
DiseaseAcute Myeloid Leukemia (AML-M2)

CD44 FOXO1

2.90e-03125192C1879321
DiseaseLeukemia, Myelocytic, Acute

CD44 FOXO1

5.47e-03173192C0023467

Protein segments in the cluster

PeptideGeneStartEntry
RRSPSSPSHPHMASQ

C5orf63

71

A6NC05
ASDRSHPATFPTRMH

AHRR

561

A9YTQ3
LHMPSTDPRHARSPE

GCSAM

131

Q8N6F7
AHQSRRPHLPMSPST

FAM186B

586

Q8IYM0
HTPPVPNTMATTHGR

MUC5B

2186

Q9HC84
QHSRSMSMPVAHSPP

IRS2

426

Q9Y4H2
GRPLPHTVSTMPHTS

FOXO1

536

Q12778
AHTSHPMQGRTTPSP

CD44

431

P16070
SQEHTPHPCRSAMAP

NYAP1

66

Q6ZVC0
STSSPASPAMERRHP

SYN3

31

O14994
PRPQPSHSRSSSLDM

REPS1

551

Q96D71
PRMHHFPRNSSSTQM

RNF165

191

Q6ZSG1
RPYNSASMSPGHPTH

NCOR1

1691

O75376
HSMPTHSSPRSRDYN

CLASP2

1006

O75122
RGSHSPTMSQRSAPP

C11orf91

6

Q3C1V1
TRDSHDSHLMPSPAP

TROAP

296

Q12815
SSPSPATRMHSGQHS

NFATC3

961

Q12968
SSRADPPPHSHMATR

ZBTB47

366

Q9UFB7
PPPHSHMATRSRENA

ZBTB47

371

Q9UFB7
RSHPPSVRMPSSSLS

ZFC3H1

111

O60293
PPGTMVTAPHSSTRH

TMEM108

46

Q6UXF1