Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninositol 1,4,5-trisphosphate-gated calcium channel activity

ITPR2 ITPR3

4.98e-053822GO:0005220
GeneOntologyCellularComponentcollagen type IV trimer

COL4A2 COL4A4

2.20e-046812GO:0005587
GeneOntologyCellularComponentbasement membrane collagen trimer

COL4A2 COL4A4

4.09e-048812GO:0098651
GeneOntologyCellularComponentnetwork-forming collagen trimer

COL4A2 COL4A4

4.09e-048812GO:0098642
GeneOntologyCellularComponentcollagen network

COL4A2 COL4A4

4.09e-048812GO:0098645
GeneOntologyCellularComponentplatelet dense tubular network membrane

ITPR2 ITPR3

5.25e-049812GO:0031095
GeneOntologyCellularComponentaxonal growth cone

TRPV2 LRP2 PARD3

7.07e-0445813GO:0044295
GeneOntologyCellularComponentchaperonin-containing T-complex

CCT8L2 CCT8L1P

7.97e-0411812GO:0005832
GeneOntologyCellularComponentplatelet dense tubular network

ITPR2 ITPR3

7.97e-0411812GO:0031094
DomainInsP3_rcpt-bd

ITPR2 ITPR3

5.56e-053812IPR000493
DomainC4

COL4A2 COL4A4

2.76e-046812SM00111
DomainRIH_assoc

ITPR2 ITPR3

2.76e-046812PF08454
Domain-

COL4A2 COL4A4

2.76e-0468122.170.240.10
DomainCollagen_VI_NC

COL4A2 COL4A4

2.76e-046812IPR001442
DomainRIH_assoc-dom

ITPR2 ITPR3

2.76e-046812IPR013662
DomainRIH_dom

ITPR2 ITPR3

2.76e-046812IPR000699
DomainIns145_P3_rcpt

ITPR2 ITPR3

2.76e-046812IPR014821
DomainRyanodine_recept-rel

ITPR2 ITPR3

2.76e-046812IPR015925
DomainC4

COL4A2 COL4A4

2.76e-046812PF01413
Domain-

ITPR2 ITPR3

2.76e-0468121.25.10.30
DomainRYDR_ITPR

ITPR2 ITPR3

2.76e-046812PF01365
DomainNC1_IV

COL4A2 COL4A4

2.76e-046812PS51403
DomainIns145_P3_rec

ITPR2 ITPR3

2.76e-046812PF08709
DomainEGF_3

FBLN7 FAT2 CNTNAP5 LRP2 SSPOP LDLR

5.50e-04235816PS50026
DomainLDLR_class-A_CS

LRP2 SSPOP LDLR

6.92e-0440813IPR023415
DomainMIR

ITPR2 ITPR3

8.17e-0410812PS50919
DomainMIR

ITPR2 ITPR3

8.17e-0410812PF02815
DomainMIR

ITPR2 ITPR3

8.17e-0410812SM00472
DomainMIR_motif

ITPR2 ITPR3

8.17e-0410812IPR016093
DomainEGF_1

FBLN7 FAT2 CNTNAP5 LRP2 SSPOP LDLR

8.43e-04255816PS00022
DomainLdl_recept_a

LRP2 SSPOP LDLR

9.78e-0445813PF00057
DomainEGF_2

FBLN7 FAT2 CNTNAP5 LRP2 SSPOP LDLR

1.03e-03265816PS01186
Domain-

LRP2 SSPOP LDLR

1.04e-03468134.10.400.10
DomainLDLRA_1

LRP2 SSPOP LDLR

1.18e-0348813PS01209
DomainLDLRA_2

LRP2 SSPOP LDLR

1.25e-0349813PS50068
DomainLDrepeatLR_classA_rpt

LRP2 SSPOP LDLR

1.25e-0349813IPR002172
DomainLDLa

LRP2 SSPOP LDLR

1.25e-0349813SM00192
DomainIon_trans_dom

KCNV2 TRPV2 ITPR2 ITPR3

1.53e-03114814IPR005821
DomainIon_trans

KCNV2 TRPV2 ITPR2 ITPR3

1.53e-03114814PF00520
DomainMORN

MORN1 JPH2

1.63e-0314812SM00698
DomainTIL_dom

LRP2 SSPOP

1.63e-0314812IPR002919
DomainLdl_recept_b

LRP2 LDLR

1.63e-0314812PF00058
DomainLDLRB

LRP2 LDLR

1.63e-0314812PS51120
DomainMORN

MORN1 JPH2

1.88e-0315812IPR003409
DomainMORN

MORN1 JPH2

1.88e-0315812PF02493
DomainLY

LRP2 LDLR

1.88e-0315812SM00135
DomainLDLR_classB_rpt

LRP2 LDLR

1.88e-0315812IPR000033
DomainEGF_CA

FBLN7 FAT2 LRP2 LDLR

1.96e-03122814SM00179
DomainEGF-like_Ca-bd_dom

FBLN7 FAT2 LRP2 LDLR

2.08e-03124814IPR001881
DomainCyclophilin-type_PPIase_CS

PPIG CWC27

3.03e-0319812IPR020892
DomainEGF

FBLN7 FAT2 CNTNAP5 LRP2 LDLR

3.56e-03235815SM00181
DomainFA58C

CNTNAP5 SSPOP

3.70e-0321812SM00231
DomainCyclophilin-type_PPIase

PPIG CWC27

3.70e-0321812IPR024936
DomainFA58C_3

CNTNAP5 SSPOP

3.70e-0321812PS50022
DomainFA58C_1

CNTNAP5 SSPOP

3.70e-0321812PS01285
DomainFA58C_2

CNTNAP5 SSPOP

3.70e-0321812PS01286
DomainCyclophilin-like_dom

PPIG CWC27

4.06e-0322812IPR029000
DomainCSA_PPIASE_2

PPIG CWC27

4.06e-0322812PS50072
DomainPro_isomerase

PPIG CWC27

4.06e-0322812PF00160
Domain-

PPIG CWC27

4.06e-03228122.40.100.10
DomainCyclophilin-type_PPIase_dom

PPIG CWC27

4.06e-0322812IPR002130
DomainCSA_PPIASE_1

PPIG CWC27

4.06e-0322812PS00170
DomainEGF-like_dom

FBLN7 FAT2 CNTNAP5 LRP2 LDLR

4.55e-03249815IPR000742
DomainF5_F8_type_C

CNTNAP5 SSPOP

4.82e-0324812PF00754
DomainFA58C

CNTNAP5 SSPOP

4.82e-0324812IPR000421
DomainABC_membrane

ABCB11 TAP1

4.82e-0324812PF00664
DomainRicin_B_lectin

GALNT1 GALNT13

5.22e-0325812PF00652
DomainEGF_CA

FBLN7 LRP2 LDLR

6.21e-0386813PF07645
DomainABC_TM1F

ABCB11 TAP1

6.53e-0328812PS50929
DomainRICIN

GALNT1 GALNT13

6.53e-0328812SM00458
DomainABC1_TM_dom

ABCB11 TAP1

6.53e-0328812IPR011527
DomainRICIN_B_LECTIN

GALNT1 GALNT13

6.53e-0328812PS50231
DomainRicin_B_lectin

GALNT1 GALNT13

7.47e-0330812IPR000772
DomainGlycos_transf_2

GALNT1 GALNT13

7.47e-0330812PF00535
DomainGlyco_trans_2-like

GALNT1 GALNT13

7.47e-0330812IPR001173
Domain-

FAT2 CNTNAP5 CLSTN2

8.17e-03958132.60.120.200
DomainEGF_Ca-bd_CS

FBLN7 LRP2 LDLR

8.65e-0397813IPR018097
PathwayBIOCARTA_VITCB_PATHWAY

COL4A2 COL4A4 SLC2A14

1.73e-0512623MM1526
Pubmed

Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China.

ABCB11 LDLR ALOX5

7.28e-07883319888660
Pubmed

Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome.

COL4A2 COL4A4 MMP2

1.09e-06983310880400
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

TRMT9B HIVEP2 MCM8 MORN1 MYO6 POLG RPS6KB1 TRIOBP ZFHX2 SLITRK3 PACRG PARD3 PBX3 SSPOP CREBBP

2.18e-061489831528611215
Pubmed

Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.

ITPR2 ITPR3

5.63e-0628329065779
Pubmed

PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease.

PBX3 MEIS1

5.63e-06283226747896
Pubmed

Revisiting the human polypeptide GalNAc-T1 and T13 paralogs.

GALNT1 GALNT13

5.63e-06283227913570
Pubmed

Chinese yellow wine and red wine inhibit matrix metalloproteinase-2 and improve atherosclerotic plaque in LDL receptor knockout mice.

MMP2 LDLR

5.63e-06283220370796
Pubmed

Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

5.63e-0628328081734
Pubmed

Structures of collagen IV globular domains: insight into associated pathologies, folding and network assembly.

COL4A2 COL4A4

5.63e-06283230443360
Pubmed

Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.

ITPR2 ITPR3

5.63e-06283215632133
Pubmed

High-resolution maps of the murine Chromosome 2 region containing the cholesterol gallstone locus, Lith1.

LRP2 ABCB11

5.63e-06283210556425
Pubmed

Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.

ITPR2 ITPR3

5.63e-06283217496801
Pubmed

Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice.

LDLR ALOX5

5.63e-06283212142344
Pubmed

Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.

ITPR2 ITPR3

5.63e-06283224901844
Pubmed

Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.

ITPR2 ITPR3

5.63e-06283233854148
Pubmed

Heparin inhibits the production of matrix metalloproteinase-2 and improves atherosclerosis in LDL receptor-deficient mice.

MMP2 LDLR

5.63e-06283219940766
Pubmed

Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.

ITPR2 ITPR3

5.63e-06283219528657
Pubmed

Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.

ITPR2 ITPR3

5.63e-0628328063813
Pubmed

IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism.

ITPR2 ITPR3

5.63e-06283216195467
Pubmed

Inositol (1,4,5)-trisphosphate receptor links to filamentous actin are important for generating local Ca2+ signals in pancreatic acinar cells.

ITPR2 ITPR3

5.63e-06283215713744
Pubmed

Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation.

COL4A2 COL4A4 LDLR

1.04e-05188339160753
Pubmed

Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.

ITPR2 ITPR3

1.69e-05383210874040
Pubmed

Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.

ITPR2 ITPR3

1.69e-05383220395455
Pubmed

Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.

ITPR2 ITPR3

1.69e-05383217437169
Pubmed

Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability.

LDLR ALOX5

1.69e-05383216698924
Pubmed

Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.

ITPR2 ITPR3

1.69e-05383218547250
Pubmed

Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.

ITPR2 ITPR3

1.69e-05383236350267
Pubmed

The versatility and universality of calcium signalling.

ITPR2 ITPR3

1.69e-05383211413485
Pubmed

MMP-2 inhibits PCSK9-induced degradation of the LDL receptor in Hepa1-c1c7 cells.

MMP2 LDLR

1.69e-05383225613181
Pubmed

Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

1.69e-05383226009177
Pubmed

CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice.

LDLR RASGRP2

1.69e-05383226988592
Pubmed

Receptor-activated single channels in intact human platelets.

ITPR2 ITPR3

1.69e-0538321693919
Pubmed

Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

ITPR2 ITPR3

1.69e-05383223955339
Pubmed

Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation.

MYO6 CLRN1

1.69e-05383219414487
Pubmed

Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.

ITPR2 ITPR3

1.69e-05383231979185
Pubmed

Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.

ITPR2 ITPR3

1.69e-05383224904548
Pubmed

Cyclic AMP responsive element-binding protein induces metastatic renal cell carcinoma by mediating the expression of matrix metallopeptidase-2/9 and proteins associated with epithelial-mesenchymal transition.

MMP2 CREBBP

1.69e-05383228487942
Pubmed

Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.

ITPR2 ITPR3

1.69e-0538329858485
Pubmed

Pbx3 deficiency results in central hypoventilation.

PBX3 MEIS1

1.69e-05383215466398
Pubmed

The collagen binding domain of gelatinase A modulates degradation of collagen IV by gelatinase B.

COL4A4 MMP2

1.69e-05383219109975
Pubmed

Rescue of calcineurin Aα(-/-) mice reveals a novel role for the α isoform in the salivary gland.

ITPR2 ITPR3

1.69e-05383221435446
Pubmed

Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.

ITPR2 ITPR3

1.69e-0538329808793
Pubmed

RNA interference-mediated silencing of laminin receptor 1 (LR1) suppresses migration and invasion and down-regulates matrix metalloproteinase (MMP)-2 and MMP-9 in trophoblast cells: implication in the pathogenesis of preeclampsia.

RPSA MMP2

1.69e-05383223729238
Pubmed

AG-9, an Elastin-Derived Peptide, Increases In Vitro Oral Tongue Carcinoma Cell Invasion, through an Increase in MMP-2 Secretion and MT1-MMP Expression, in a RPSA-Dependent Manner.

RPSA MMP2

1.69e-05383233396696
Pubmed

Collagen types in various layers of the human aorta and their changes with the atherosclerotic process.

COL4A2 COL4A4

1.69e-0538323089234
Pubmed

Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.

ITPR2 ITPR3

1.69e-05383218194433
Pubmed

Polypeptide N-Acetylgalactosaminyltransferase 13 Contributes to Neurogenesis via Stabilizing the Mucin-type O-Glycoprotein Podoplanin.

GALNT1 GALNT13

1.69e-05383227629416
Pubmed

IP3 receptors regulate vascular smooth muscle contractility and hypertension.

ITPR2 ITPR3

1.69e-05383227777977
Pubmed

Pbx3 and Meis1 cooperate through multiple mechanisms to support Hox-induced murine leukemia.

PBX3 MEIS1

1.69e-05383225911551
Pubmed

Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.

ITPR2 ITPR3

1.69e-05383217581770
Pubmed

Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.

ITPR2 ITPR3

1.69e-05383218241669
Pubmed

Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.

ITPR2 ITPR3

1.69e-05383219068129
Pubmed

Dangerous liaisons: cooperation between Pbx3, Meis1 and Hoxa9 in leukemia.

PBX3 MEIS1

1.69e-05383226130510
Pubmed

Liver receptor homolog 1 transcriptionally regulates human bile salt export pump expression.

NR5A2 ABCB11

1.69e-05383218270374
Pubmed

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

1.69e-05383217327232
Pubmed

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.

ITPR2 ITPR3

1.69e-05383216014380
Pubmed

Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen.

GALNT1 GALNT13

1.69e-05383212407114
Pubmed

SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport.

NR5A2 LDLR

1.69e-05383225176150
Pubmed

Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.

PBX3 MEIS1

1.69e-05383217942707
Pubmed

Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.

ITPR2 ITPR3

1.69e-05383217890015
Pubmed

Angiotensinogen and Megalin Interactions Contribute to Atherosclerosis-Brief Report.

LRP2 LDLR

1.69e-05383230567480
Pubmed

Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.

ITPR2 ITPR3

1.69e-05383223983250
Pubmed

Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.

ITPR2 ITPR3

1.69e-05383220427533
Pubmed

The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons.

ALDH1A1 PBX3 MEIS1

1.95e-052283322748019
Pubmed

Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.

GALNT1 LRP2 GALNT13

2.56e-052483331740596
Pubmed

Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.

ITPR2 ITPR3

3.37e-05483225215520
Pubmed

Nature and the multiple functions of the 67-kD elastin-/laminin binding protein.

COL4A2 COL4A4

3.37e-0548327827955
Pubmed

Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor.

ITPR2 ITPR3

3.37e-05483217925404
Pubmed

IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis.

ITPR2 ITPR3

3.37e-05483226193638
Pubmed

USH3A transcripts encode clarin-1, a four-transmembrane-domain protein with a possible role in sensory synapses.

MYO6 CLRN1

3.37e-05483212080385
Pubmed

PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1.

CREBBP LDLR

3.37e-05483218660751
Pubmed

Inhibition of hypoxia inducible factor-1α attenuates abdominal aortic aneurysm progression through the down-regulation of matrix metalloproteinases.

MMP2 LDLR

3.37e-05483227363580
Pubmed

Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

3.37e-05483211163362
Pubmed

Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles.

MYO6 LRP2

3.37e-05483216908842
Pubmed

Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.

ITPR2 ITPR3

3.37e-05483221424589
Pubmed

Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.

ITPR2 ITPR3

3.37e-05483228615414
Pubmed

Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease.

PBX3 MEIS1

3.37e-05483218723445
Pubmed

Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.

ITPR2 ITPR3

3.37e-05483210828023
Pubmed

IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.

ITPR2 ITPR3

3.37e-05483228419336
Pubmed

IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.

ITPR2 ITPR3

3.37e-05483235494252
Pubmed

UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree.

GALNT1 GALNT13

5.60e-05583222186971
Pubmed

Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509.

LRP2 LDLR

5.60e-05583218685438
Pubmed

In vitro interactions of oxidatively modified LDL with type I, II, III, IV, and V collagen, laminin, fibronectin, and poly-D-lysine.

COL4A2 COL4A4

5.60e-0558329409248
Pubmed

Role of nuclear receptor coactivator 3 (Ncoa3) in pluripotency maintenance.

NR5A2 CREBBP

5.60e-05583222977234
Pubmed

Expression of Meis and Pbx genes and their protein products in the developing telencephalon: implications for regional differentiation.

PBX3 MEIS1

5.60e-05583210842069
Pubmed

InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.

ITPR2 ITPR3

5.60e-05583221568942
Pubmed

Expression of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase isoforms in murine tissues determined by real-time PCR: a new view of a large family.

GALNT1 GALNT13

5.60e-05583212651884
Pubmed

Hypoxic adaptation engages the CBP/CREST-induced coactivator complex of Creb-HIF-1α in transactivating murine neuroblastic glucose transporter.

SLC2A14 CREBBP

5.60e-05583223321477
Pubmed

HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells.

PBX3 MEIS1

5.60e-05583210082572
Pubmed

Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors.

ITPR2 ITPR3

5.60e-05583221436055
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

TPR UBAP2 FAM193A MYO6 PARG COPS4 RPSA EIF3I PPP6R2 AHSA1

7.69e-05934831033916271
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

ITPR2 ITPR3

8.39e-05683223463619
Pubmed

Extracellular matrix of the human optic nerve head.

COL4A2 COL4A4

8.39e-0568322426947
Pubmed

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.

LRP2 LDLR

8.39e-0568329837937
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

ITPR2 ITPR3

8.39e-05683225966694
Pubmed

Complex inheritance of the 5-lipoxygenase locus influencing atherosclerosis in mice.

LDLR ALOX5

8.39e-05683216624897
Pubmed

Insertional mutation of the collagen genes Col4a3 and Col4a4 in a mouse model of Alport syndrome.

COL4A2 COL4A4

8.39e-05683210534397
Pubmed

Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes.

PBX3 MEIS1

8.39e-05683211438208
Pubmed

Characterization of TALE genes expression during the first lineage segregation in mammalian embryos.

PBX3 MEIS1

8.39e-05683222987645
Pubmed

Developmental distribution of collagen IV isoforms and relevance to ocular diseases.

COL4A2 COL4A4

8.39e-05683219275937
GeneFamilyInositol 1,4,5-triphosphate receptors|Protein phosphatase 1 regulatory subunits

ITPR2 ITPR3

2.43e-053522297
GeneFamilyATP binding cassette subfamily B

ABCB11 TAP1

4.39e-0411522806
GeneFamilyLow density lipoprotein receptors

LRP2 LDLR

6.20e-0413522634
GeneFamilyCadherin related

FAT2 CLSTN2

1.07e-031752224
GeneFamilyCyclophilin peptidylprolyl isomerases

PPIG CWC27

1.34e-0319522909
GeneFamilyPolypeptide N-acetylgalactosaminyltransferases

GALNT1 GALNT13

1.49e-0320522433
GeneFamilyTALE class homeoboxes and pseudogenes

PBX3 MEIS1

2.52e-0326522526
GeneFamilyCollagens

COL4A2 COL4A4

7.74e-0346522490
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CAPN12 DLGAP1 LRP2 CLSTN2 PARD3 ALPK2

1.38e-061878369d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CAPN12 DLGAP1 LRP2 CLSTN2 PARD3 ALPK2

1.46e-061898363b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CAPN12 DLGAP1 LRP2 CLSTN2 PARD3 ALPK2

1.46e-0618983628b502611829e4a24caff2562545c7db97686099
ToppCellCOVID-19-kidney-PCT-S2|kidney / Disease (COVID-19 only), tissue and cell type

CAPN12 DLGAP1 LRP2 CLSTN2 PARD3 ALPK2

1.46e-061898360be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CAPN12 DLGAP1 LRP2 CLSTN2 PARD3 ALPK2

1.51e-06190836989d4eefd22d66ecb857836f8fdbcf41e3047f84
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A2 DLGAP1 LRP2 CLSTN2 PARD3 ALPK2

1.56e-061918361cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CAPN12 COL4A2 DLGAP1 LRP2 CLSTN2 ALPK2

1.92e-06198836be305d89d48c67ce922fa71aaf15e24d00c89ff6
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WDR64 KCNV2 LRP2 PTCHD4 GALNT13

1.24e-05160835c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WDR64 KCNV2 LRP2 PTCHD4 GALNT13

1.24e-0516083525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A2 COL4A4 IGFN1 GAL3ST4 MEIS1

1.32e-051628355f009b231f21861afee9cc0c569082e1135f929c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A2 COL4A4 IGFN1 GAL3ST4 MEIS1

1.32e-05162835b936f8040dcd4db621ccded19237af8df7d0ed6e
ToppCellControl|World / group, cell type (main and fine annotations)

DLGAP1 MYO6 LRP2 PARD3 LDLR

1.57e-05168835a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCellControl-Epithelial_cells-ECM-high_epithelial|Control / group, cell type (main and fine annotations)

COL4A2 COL4A4 MYO6 PARD3 LDLR

1.66e-05170835e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCellAT1-AT2_cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

COL4A2 COL4A4 DLGAP1 ERVW-1 EHD2

1.91e-051758359a95ab5c361ebaa8747983c5a0d69025682a19ad
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL4A2 COL4A4 PTCHD4 SSPOP RASGRP2

2.43e-05184835ae0a77e3e520a246b17776bb19503519636b02ee
ToppCell3'_v3-bone_marrow-Hematopoietic_progenitors-Progenitor_MEMP|bone_marrow / Manually curated celltypes from each tissue

CNTNAP5 ZNRF1 ALDH1A1 MEIS1 EHD2

2.43e-05184835b81a2a95944cee8fec13d63dc0d95496e67aa937
ToppCellCOVID-19_Moderate-HSPC|COVID-19_Moderate / disease group, cell group and cell class

ZNRF1 ALDH1A1 MMP2 MEIS1 EHD2

2.49e-05185835cacc6ab5f26f6c803894567fb838ea06eaa7efe5
ToppCell(8)_CD34_progenitor|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

ZNRF1 ALDH1A1 MMP2 MEIS1 EHD2

2.56e-05186835943c604a7cd873faf510096d094100512ba2d6bc
ToppCell(8)_CD34_progenitor|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

ZNRF1 ALDH1A1 MMP2 MEIS1 EHD2

2.56e-05186835e69a986b8618effd61875fda528a2e44aab11868
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CAPN12 DLGAP1 LRP2 PARD3 ALPK2

2.56e-05186835b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCellCOVID-19-kidney-tDL|kidney / Disease (COVID-19 only), tissue and cell type

CAPN12 DLGAP1 LRP2 PARD3 ALPK2

2.62e-05187835d35d27ca3c0e65f92f4508e1cb98a743f44fdcdf
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CAPN12 DLGAP1 LRP2 CLSTN2 ALPK2

2.76e-05189835204ab61ae606b2d9be0cb6bf6a83a011740693a8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CAPN12 DLGAP1 LRP2 CLSTN2 ALPK2

2.76e-0518983513fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-bronchial_smooth_muscle_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A4 JPH2 GAL3ST4 CLSTN2 PTCHD4

2.76e-051898354dc32b463546bbe7250dddd281b92ad17ec22da1
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Airway_Smooth_Muscle|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A4 JPH2 GAL3ST4 CLSTN2 PTCHD4

2.76e-051898350d06bf0d7191d13a1c4f30a7881e7ea1093bfd6f
ToppCellLPS_only-Stromal_mesenchymal|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

COL4A2 DLGAP1 ALDH1A1 MMP2 MEIS1

2.98e-05192835162d8b5858d150ecbbd1c9bf2b19c6c9cd50a158
ToppCellLA-14._Fibroblast_III|LA / Chamber and Cluster_Paper

COL4A2 COL4A4 HIVEP2 LDLR MEIS1

3.05e-051938357426c291bac59e539c427bcaae18abc7d397d44e
ToppCell18-Airway-Mesenchymal-Pericyte|Airway / Age, Tissue, Lineage and Cell class

COL4A2 IGFN1 SLC2A14 JPH2 EHD2

3.05e-051938359f4ba9c29ab8071d57e4187085ec3a47ab61e968
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DLGAP1 MYO6 LRP2 PACRG PARD3

3.13e-051948357002937e8903e037332a215d00fbc7c7843b33f2
ToppCellLA-14._Fibroblast_III|World / Chamber and Cluster_Paper

COL4A2 COL4A4 HIVEP2 CLSTN2 MEIS1

3.13e-05194835803fa83ceada17c38ca9f933b888f7e7b0b90761
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

MYO6 CNIH4 TRPV2 ALDH1A1 ALOX5

3.29e-05196835fe90501010128b72e6711c567cb04b012f1520a4
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL4A2 MMP2 PBX3 MEIS1 EHD2

3.45e-05198835ebceb11f50b8a6ebb7629fdbd3d31fb131ace6fd
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

COL4A2 HIVEP2 MYO6 TAP1 EHD2

3.62e-05200835edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CAPN12 LRP2 CLSTN2 ALDH1A1 ALPK2

3.62e-05200835105564ee05bd11685b5747ee32d5350cf3c2e2e1
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Serpinf1-Serpinf1_Clrn1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ST6GALNAC1 FBLN7 PBX3 CLRN1

3.69e-051008342e1c6fa2b48a6e3367b76b79dec58aea9c4662e0
ToppCell(09)_Ionocytes-(3)_72hpi|(09)_Ionocytes / shred by cell type and Timepoint

UBAP2 POLG ZFHX2 ALOX5

5.36e-05110834fce7d5a0617fc664b657f5bb9abb290e7cc234cb
ToppCellControl-Epithelial_alveolar-AT_2-AT1-AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ST6GALNAC1 ZFHX2 GRHL3 ALPK2

6.81e-05117834c6fc72608d56a389bcd87b5dc98a11e39b79bcb2
ToppCellSmart-seq2-blood_(Smart-seq2)-hematologic-hematopoietic_progenitor-hematopoietic_stem_cell|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ZFHX2 ALDH1A1 MEIS1 EHD2

1.73e-04149834e99b7cd3728ce76b365526734c2e7f845b2e62c8
ToppCellSmart-seq2-blood_(Smart-seq2)-hematologic-hematopoietic_progenitor|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ZFHX2 ALDH1A1 MEIS1 EHD2

1.73e-041498346a28dd4530ed411747fdfe743db138a1b5547ed7
ToppCellileum-BEST4+_Enterocytes|ileum / shred on tissue and cell subclass

GRHL3 PBX3 MEIS1 ITPR2

1.97e-04154834608e9c982125e0c2c15b86b1920813845a0db81f
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_1|343B / Donor, Lineage, Cell class and subclass (all cells)

PCF11 FBLN7 FAM193A SLC2A14

2.02e-04155834a4ff78e2efc6fe9a513bb2b64e5848f2ce65a09f
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Vcan_(SNc)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

NUTM1 NR5A2 CCT8L1P

2.02e-046183312de8c495c7f47ecd720f29a573471705603732a
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Vcan_(SNc)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

NUTM1 NR5A2 CCT8L1P

2.02e-0461833a655232c6d92335eb086723ab9b05eb3a5479b68
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Nefm|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

FAT2 WDR64 ALPK2

2.12e-04628333eec7f31de7cc24762c5b180475650676437dc76
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Nefm-Inhibitory_Neuron.Chat-Gad1Gad2-Slc17a8.Nefm_(Globus_Pallidus/Nucleus_Basalis_(GP/NB),_cholinergic)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

FAT2 WDR64 ALPK2

2.12e-0462833f5f5441f5be00ab80a7827c4af1afbe45c552c2e
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Nefm-Inhibitory_Neuron.Chat-Gad1Gad2-Slc17a8.Nefm_(Globus_Pallidus/Nucleus_Basalis_(GP/NB),_cholinergic)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

FAT2 WDR64 ALPK2

2.12e-04628336e81a37b9defa96528654bee1b23152108d9c0b7
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A4 SLITRK3 MEIS1 RASGRP2

2.22e-04159834e812cbde59188924c6277c3feadf1a9592fa62a4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A4 SLITRK3 MEIS1 RASGRP2

2.22e-041598342607b562903228274fbd96168ba826782fab0b53
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ST6GALNAC1 RWDD2B ALDH1A1 PARD3

2.33e-041618349cfbbcd38ec2e75376bbc26001964b6991ad0e21
ToppCellfacs-Trachea-18m-Epithelial-glandular_epithelial-lung_secretory_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL4A4 LRP2 CLSTN2 ALPK2

2.50e-04164834cdb8cd2d6b369189ea77e4946738e2816d502e03
ToppCellfacs-Trachea-18m-Epithelial-glandular_epithelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL4A4 LRP2 CLSTN2 ALPK2

2.50e-041648345dbfcdd450f652b16d97da53b528d4584b0eabcf
ToppCellfacs-Trachea-18m-Epithelial-glandular_epithelial-lung_secretory_cell-mucous|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL4A4 LRP2 CLSTN2 ALPK2

2.50e-04164834f1423f4434af4af9c60c8a5b0b0abec4a7df9401
ToppCell356C-Endothelial_cells-Endothelial-E|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PPIG ZFHX2 MMP2 LDLR

2.80e-041698340425d2580ed325178f522c0093ff4623de6ce7a8
ToppCell356C-Endothelial_cells-Endothelial-E-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PPIG ZFHX2 MMP2 LDLR

2.80e-04169834fec669968a77060bd77ee8695034e35a642c984f
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL4A2 CLSTN2 PTCHD4 RASGRP2

2.87e-041708341f994b690e881106a5d54b3080ccce6260bc3ac5
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-9|TCGA-Bladder / Sample_Type by Project: Shred V9

ST6GALNAC1 FAT2 GALNT1 ABCB11

2.93e-04171834adbcfa4bf6bc1c604535a24435924cdb091e2dd7
ToppCellprimary_auditory_cortex_(A1C)|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL4A2 SLC2A14 PARD3 MEIS1

3.00e-0417283420ea9db009370aa6235365ce93e153eb5b28db94
ToppCellAT1_cells-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

COL4A2 COL4A4 LDLR EHD2

3.06e-041738343afca2a429c634af0220c1aa19ce4cf4ee3e8b3e
ToppCellIonocyte-iono-2|World / Class top

PDPR ABCB11 GALNT13 ITPR2

3.06e-04173834e5ec28ccc5e048fd98de4c876e5c53b866b66228
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

CNIH4 CWC27 CRAT RASGRP2

3.13e-04174834eaaf17a06efc09ed4752b449827b1f0f424d3dad
ToppCellAT1-AT2_cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

COL4A2 COL4A4 ERVW-1 EHD2

3.20e-04175834bdd85ba280648a0283c1984662a34c7b840f64dd
ToppCellfacs-Aorta|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A2 NR5A2 LRP2 SSPOP

3.27e-041768340b3491451be02c18a16cdb875645be47eb867a7f
ToppCellAT1_cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

COL4A2 COL4A4 GALNT13 EHD2

3.27e-04176834458720776b0151cd55acc352d509599cb62f0ca8
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CAPN12 SLC2A14 LRP2 ALPK2

3.27e-041768341595dbeee336a81e581325d63208ec6262664ee9
ToppCellAT1_cells-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

COL4A2 COL4A4 LDLR EHD2

3.34e-041778343128b8d04687acee1ac4190b2569d6328b98eaf3
ToppCelldroplet-Lung-nan-3m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAPN12 TRMT9B CLSTN2 SSPOP

3.34e-0417783465709bd546cb1ec6aa2ddd8b2adb46e174eb9a9a
ToppCelldroplet-Lung-nan-3m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAPN12 TRMT9B CLSTN2 SSPOP

3.34e-041778348684d47a547e2a06496f15e8da0200ecddc431e0
ToppCellcontrol-Others-CD34+_GATA2+_cells|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ZNRF1 MMP2 MEIS1 EHD2

3.41e-041788342120bd3e099b0b271bf079db9827a2f3eee2f909
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DLGAP1 SLITRK3 RWDD2B GRHL3

3.41e-04178834ef490b45901b2e6dedb519540fa3ae4e4db3a9ba
ToppCellCOVID-19-kidney-Epi_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

DLGAP1 LRP2 PARD3 ALPK2

3.41e-04178834544379f5a6145429762258d426b876bb36c112f5
ToppCellCOVID-19-Epithelial_cells-AT1|COVID-19 / group, cell type (main and fine annotations)

COL4A4 MYO6 PARD3 GALNT13

3.48e-04179834a0b33bd69ffdfd5d38d80207fb40058a490aa19e
ToppCellCOVID-19-kidney-Epi_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

JPH2 PTCHD4 MEIS1 ALPK2

3.48e-04179834e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCellPBMC-Mild-Hematopoietic-HSPC-HSPC-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNRF1 MMP2 MEIS1 EHD2

3.48e-041798344bb2debfc9e9f258cd38e797ef160bd440aad6af
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CAPN12 LRP2 PARD3 ALPK2

3.48e-0417983458ae5a97fe2a14e1c6fdeb886397eb06fdaf0428
ToppCellPBMC-Mild-Hematopoietic-HSPC|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNRF1 MMP2 MEIS1 EHD2

3.48e-041798342f690f933bf6b99abeb31766e0b22bdbe36c1ba0
ToppCellPBMC-Mild-Hematopoietic-HSPC-HSPC|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNRF1 MMP2 MEIS1 EHD2

3.48e-041798343e2c937369b8190fd5d5a31689d029e6e89fb5e2
ToppCellCOVID-19-kidney-PCT-S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

CAPN12 DLGAP1 LRP2 ALPK2

3.56e-04180834358923e4228035a3e90e2957392089219e90dcd7
ToppCelldroplet-Limb_Muscle-nan-18m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A2 FBLN7 RPSA MMP2

3.56e-04180834d3d0be136fff5d3e39ecf5a5dbefc1d0d0a6c814
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NR5A2 JPH2 PTCHD4 TAP1

3.56e-04180834455d1e3ccf2ab609954f3b870e8f514ddca735f4
ToppCelldroplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRMT9B CLSTN2 GRHL3 RASGRP2

3.56e-0418083478fdcfb3fdbf36469cae78407cda5bd0996930d8
ToppCellLPS-antiTNF-Endothelial-Endothelial-Alv_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

COL4A2 MYO6 ZNRF1 EHD2

3.56e-0418083430cf3c7ee29694eaccb89bf8053a82037d5c9f1d
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_GGT8P|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL4A2 COL4A4 PTCHD4 SSPOP

3.63e-041818349842537f9a607d8557c43790008d175edab1f32c
ToppCellPBMC-Mild-Hematopoietic-HSPC-HSPC-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ZNRF1 MMP2 MEIS1 EHD2

3.63e-04181834e7f7b519c2a01c15f26df11ec9b434c0d1630c7a
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CAPN12 DLGAP1 LRP2 ALPK2

3.63e-041818349542c19edc9bd2cba68c01c2a8407705398e3011
ToppCelldroplet-Heart-nan-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A2 MYO6 NR5A2 ITPR2

3.63e-0418183492d44892bb15771f0ab5fe61879b204b0acbd9b3
ToppCellPBMC-Mild-Hematopoietic-HSPC-HSPC|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

ZNRF1 MMP2 MEIS1 EHD2

3.63e-0418183454a19cf6a3b752e2391feb8b316bebee0e602d17
ToppCellPBMC-Mild-Hematopoietic-HSPC|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

ZNRF1 MMP2 MEIS1 EHD2

3.63e-041818345b84625b1d3737708001b64f6da9360330d39a27
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CAPN12 DLGAP1 LRP2 ALPK2

3.63e-041818348f04f8cac5d705dc5f6cf6f4516d6e45b0aa4ae5
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRP2 PARD3 PTCHD4 ALPK2

3.63e-041818346956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCellPBMC-Control-Hematopoietic-HSPC-HSPC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNRF1 MMP2 MEIS1 EHD2

3.71e-04182834d0ebf2f0d5370458ab81485a0017c311077133d5
ToppCellPBMC-Control-Hematopoietic-HSPC-HSPC-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNRF1 MMP2 MEIS1 EHD2

3.71e-041828342a6d1246bfb5899a0861c7f2f8fb9b43b0df8acc
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FAT2 SLC39A6 GRHL3 ALOX5

3.71e-04182834678eadd57e7e830fc2bf9fd35616d3badce01705
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FAT2 SLC39A6 GRHL3 ALOX5

3.71e-041828348d1229fa5aa6e2e38f2ac6fe4f4dc89752fe9344
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

COL4A2 MYO6 ZNRF1 MEIS1

3.71e-04182834a20017b6a4f9a6a29e090e4dbd7c02ed1495bd50
ToppCellPBMC-Control-Hematopoietic-HSPC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNRF1 MMP2 MEIS1 EHD2

3.71e-04182834918286422b3eab32d962b49aa07b1b9512e51d9d
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PCF11 FBLN7 FAM193A SLC2A14

3.79e-04183834807d64deaf4e50dccf6f831f88578a6d903c1421
ToppCellCOPD-Epithelial-ATII|World / Disease state, Lineage and Cell class

MYO6 LRP2 PARD3 LDLR

3.79e-041838348e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCellfacs-Heart-RA-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRMT9B TRPV2 GRHL3 RASGRP2

3.79e-041838340f02136359787bd78146617990968baa47a65d86
ToppCell3'-Child09-12-SmallIntestine-Mesenchymal-myocytic-myofibroblast|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL4A2 JPH2 MMP2 EHD2

3.79e-041838346b5eef96b28911c752a8b6c0975918c4572cec38
ToppCellfacs-Heart-RA-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRMT9B TRPV2 GRHL3 RASGRP2

3.79e-041838342f0dcc65ad4d90ef946919b4462280fdd20c5ea0
DrugAcemetacin [53164-05-9]; Up 200; 9.6uM; HL60; HT_HG-U133A

COL4A2 TRMT9B MORN1 COQ6 PPP6R2 ALOX5 MVK

6.71e-061958272411_UP
DrugE 5110

PPIG COQ6 ALOX5

7.28e-0611823CID006438164
Drugbenzoquinone

TPR POLG RPS6KB1 COQ6 MMP2 TAP1 ALOX5

1.05e-05209827CID000004650
Drugadenophostin A

ITPR2 ITPR3

1.28e-052822ctd:C085029
Diseasearteriosclerosis (is_implicated_in)

MMP2 LDLR ALOX5

8.47e-0531813DOID:2349 (is_implicated_in)
Diseaseautosomal dominant polycystic kidney disease (biomarker_via_orthology)

RPS6KB1 LRP2

1.55e-047812DOID:898 (biomarker_via_orthology)
Diseaseomega-6 polyunsaturated fatty acid measurement

ABCB11 PTCHD4 PPP6R2 LDLR MVK

2.14e-04197815EFO_0005680
DiseaseMotor retardation

ERCC6 HACE1

2.65e-049812C0424230
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

ITPR2 ITPR3

4.83e-0412812DOID:1441 (implicated_via_orthology)
DiseaseMetabolic Bone Disorder

LRP2 MMP2

6.63e-0414812C0005944
DiseaseTesticular Germ Cell Tumor

MMP2 ALOX5

6.63e-0414812C1336708
DiseaseHereditary hearing loss and deafness

COL4A4 MYO6 TRIOBP CLRN1

7.12e-04146814cv:C0236038
DiseaseOsteopenia

LRP2 MMP2

7.64e-0415812C0029453
Diseasemyelodysplastic syndrome (implicated_via_orthology)

POLG CREBBP

7.64e-0415812DOID:0050908 (implicated_via_orthology)
DiseaseAlcohol abuse

ALDH1A1 MMP2 LDLR

8.41e-0467813C0085762
DiseaseNon-alcoholic Fatty Liver Disease

NR5A2 ALDH1A1 LDLR

9.55e-0470813C0400966
DiseaseNonalcoholic Steatohepatitis

NR5A2 ALDH1A1 LDLR

9.55e-0470813C3241937
Diseaseesophagus squamous cell carcinoma (is_marker_for)

MMP2 PBX3 TAP1

1.12e-0374813DOID:3748 (is_marker_for)
Diseasecortisol measurement

CNTNAP5 LDLR

1.37e-0320812EFO_0005843
DiseaseRenal glomerular disease

COL4A4 CREBBP

1.81e-0323812C0268731
DiseaseGlomerulopathy Assessment

COL4A4 CREBBP

1.81e-0323812C4521256
Diseaselipid measurement, lipoprotein measurement

PPP6R2 LDLR MVK

1.97e-0390813EFO_0004529, EFO_0004732
Diseasenephrotic syndrome (implicated_via_orthology)

COQ6 ALOX5

1.98e-0324812DOID:1184 (implicated_via_orthology)
DiseaseDyslipidemias

NR5A2 LDLR

1.98e-0324812C0242339
DiseaseDyslipoproteinemias

NR5A2 LDLR

1.98e-0324812C0598784
Diseaseage-related hearing impairment

MYO6 TRIOBP CLSTN2 MMP2 PBX3

2.01e-03324815EFO_0005782
Diseasecorpus collosum mid-posterior volume measurement

CNTNAP5 KCNV2

2.14e-0325812EFO_0010300
DiseaseSquamous cell carcinoma of esophagus

FAT2 SLC39A6 CREBBP

2.30e-0395813C0279626
Diseaseretinitis pigmentosa (implicated_via_orthology)

CWC27 CLRN1

2.50e-0327812DOID:10584 (implicated_via_orthology)
Diseasehearing impairment

ERCC6 TRIOBP CLRN1

2.51e-0398813C1384666
DiseaseCerebral Hemorrhage

COL4A2 MMP2

2.69e-0328812C2937358
Diseaseprimary biliary cholangitis (biomarker_via_orthology)

RPS6KB1 MMP2

2.69e-0328812DOID:12236 (biomarker_via_orthology)
DiseaseAutosomal Dominant Parkinsonism

POLG ALDH1A1

2.69e-0328812C0752098
DiseaseAutosomal Dominant Juvenile Parkinson Disease

POLG ALDH1A1

2.69e-0328812C0752097
DiseaseParkinsonism, Experimental

POLG ALDH1A1

2.69e-0328812C0752101
DiseaseAutosomal Recessive Parkinsonism

POLG ALDH1A1

2.69e-0328812C0752100
DiseaseFamilial Juvenile Parkinsonism

POLG ALDH1A1

2.69e-0328812C0752104
DiseaseRamsay Hunt Paralysis Syndrome

POLG ALDH1A1

2.69e-0328812C0242423
DiseasePARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE

POLG ALDH1A1

2.69e-0328812C1868675
Diseasepancreatic cancer (is_marker_for)

ALDH1A1 MMP2 ALOX5

2.74e-03101813DOID:1793 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
RGLVAMANAGSHDNG

CWC27

96

Q6UX04
RGGKFHMVDGNVSGE

AHSA1

246

O95433
REGGQSNDGNMGHEA

ALPK2

1431

Q86TB3
EVGVQGGAFEGTHMG

EHD2

406

Q9NZN4
TGHAGLNTAQAGGMA

CREBBP

251

Q92793
FLMHTGAGDQGGGQA

COL4A4

1601

P53420
LMHTAAGDEGGGQSL

COL4A2

1626

P08572
VHPLAGQGVNMGFGD

COQ6

371

Q9Y2Z9
QQFDTLVGEGGGQMS

ABCB11

546

O95342
MSGNGRELGEYGFHE

ALDH1A1

471

P00352
GQMLHGGGSRLNSGN

CRAT

306

P43155
MDGQGQRGDIISQSG

DLGAP1

571

O14490
EEEEGMGRGRHGQNG

CLSTN2

926

Q9H4D0
ANMNGIHSELNGGGE

FAM193A

321

P78312
LHCQQAGGILGDEMG

ERCC6

521

Q03468
HEALFTMGGNAEGQP

MMP2

276

P08253
FARQGIHDMLEHGGN

PACRG

126

Q96M98
QDGGNNVMRTIHGVG

ITPR2

911

Q14571
MNHGLRNGGGVGDIL

ITPR3

2466

Q14573
DGQPMGGFVMDGQQH

MEIS1

351

O00470
GGFVMDGQQHMGIRA

MEIS1

356

O00470
GMREGHGFLVDRDGQ

MORN1

116

Q5T089
VGGNSRGHFVMQRSD

FBLN7

376

Q53RD9
LAGVNLAGHSVQGGM

PBX3

11

P40426
GQFTNGMRHGYGVRQ

JPH2

131

Q9BR39
FGNLDFERSQHGSGM

MCM8

756

Q9UJA3
LGGRMGFVHNFQESN

RASGRP2

491

Q7LDG7
GEDEFQGGMVGKIHA

FAT2

3541

Q9NYQ8
LHFQFEGGESRTGMN

PARG

366

Q86W56
VHTGMLNEGGGYEND

PDPR

561

Q8NCN5
GRMNGFIDQIDGIVH

COPS4

346

Q9BT78
GIAVRFHGEEGMGQG

HACE1

581

Q8IYU2
RGLHEQIFGQGGEMP

POLG

81

P54098
EGGQLNESMDHGGVG

RPS6KB1

46

P23443
GHRAYIGRVGMDGTN

LRP2

3341

P98164
GLDDVVGFMHNAQAG

GAL3ST4

321

Q96RP7
GQAHGADRSGKDGVM

SLC2A14

491

Q8TDB8
VHGGQEQALDSPRGM

NUTM1

536

Q86Y26
DFMVQGGDFSEGNGR

PPIG

71

Q13427
EKVGIFNCHGMGGNQ

GALNT13

451

Q8IUC8
GVGMRFEGPHGQSVA

PCF11

951

O94913
NEKVGIFNCHGMGGN

GALNT1

451

Q10472
RGGHMNEAFVDFTGG

CAPN12

196

Q6ZSI9
SHPVTQVRNMGFGDG

GRHL3

586

Q8TE85
GMVQAGGQGHGLARV

LINC00304

16

Q8N9R0
MEALLEGIQNRGHGG

CEP63

1

Q96MT8
NGERLGTYMGHTGAV

EIF3I

41

Q13347
GHFSQGLADMEVQPG

IGFN1

456

Q86VF2
SMQGDGVLFHGEGQR

CNTNAP5

211

Q8WYK1
EANDHTQAAGGMRRG

PPP6R2

461

O75170
GGHGFNARVMLETQE

PARD3

1271

Q8TEW0
GLARSHGEQGQMPEN

NR5A2

51

O00482
AGTHLGGTNLDFQME

RPSA

21

P08865
EGGVNHENGMNRDGG

RHOXF1

51

Q8NHV9
QTGMSDGGGVQDQAR

ERVW-1

111

Q9UQF0
GHNIGKRMTCGDFIG

PSD

666

A5PKW4
GAMAGSGQEGRQQAV

SSPOP

426

A2VEC9
NATGGGGHVQMVQRA

ALOX5

426

P09917
MGGDENRGVTGHFTF

PSG8

126

Q9UQ74
TVEEMQQHSGQGEGG

KCNV2

281

Q8TDN2
MKDGRNSFIGHQLGG

PTCHD4

141

Q6ZW05
IQMQCHRLFEDGGGG

SLITRK3

701

O94933
AVVGNGGILNNSHMG

ST6GALNAC1

366

Q9NSC7
EGGAIREGGTHQQLM

TAP1

716

Q03518
HQGGNLLMGVGAEGI

CCT8L1P

471

A6NM43
HQGGNLLMGVGTEGI

CCT8L2

471

Q96SF2
DQLRGFIASQGMGNG

TRIOBP

2256

Q9H2D6
MGDGLHNFSDGLAIG

SLC39A6

601

Q13433
MQYGLFHGEGVRQCG

CLRN1

61

P58418
GNMGVFDPTEIHNRG

CNIH4

91

Q9P003
TIMNGHGGGRSQQTL

UBAP2

641

Q5T6F2
YQLAAHLREGGGAMG

ZFHX2

786

Q9C0A1
TETEESMGGGEGNHR

TPR

2016

P12270
SMGGGEGNHRAADSQ

TPR

2021

P12270
FNRQRGVSHAMGGRG

TPR

2341

P12270
QGERMIHGNPSGVDN

MVK

191

Q03426
GMGELAFQEQLHFRG

TRPV2

606

Q9Y5S1
VFSVNGARGNHMDFG

RWDD2B

281

P57060
DHQGEMRRNGGGNFL

TRMT9B

336

Q9P272
QGIFMGEHREGFETQ

ZNF699

86

Q32M78
EGVRSGFAMAGHENL

HIVEP2

736

P31629
EMFVSRGGHGQQDLF

TBC1D10A

166

Q9BXI6
NGYQETGGGHHRDGM

ZNRF1

101

Q8ND25
LQVFHDSQGGPGDMQ

WDR64

401

B1ANS9
TMSHQALGDVAGRGN

LDLR

766

P01130
HPTDGFQMGNIVDIG

MYO6

11

Q9UM54