Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	UBA-like	NXF1 HUWE1	1.18e-03	64	15	2	IPR009060
Domain	ARM-like	MED12 HUWE1	1.93e-02	270	15	2	IPR011989
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	RFX7 YEATS2 SCAF1 NELFA HUWE1 NFRKB	7.89e-07	774	16	6	15302935
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	YEATS2 NELFA NXF1 NFRKB	1.47e-05	339	16	4	30415952
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	YEATS2 NELFA NFRKB	3.02e-05	134	16	3	25452129
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	YEATS2 MED12 NXF1 HUWE1	3.34e-05	418	16	4	34709266
Pubmed	Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.	RFX7 HUWE1	7.45e-05	28	16	2	25752541
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	YEATS2 MED12 HUWE1 NFRKB	9.61e-05	549	16	4	38280479
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	YEATS2 NELFA MED12 NXF1 NFRKB	1.04e-04	1103	16	5	34189442
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	EIF4G3 MED12 NXF1	1.74e-04	242	16	3	34011540
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	EIF4G3 MED12 NXF1 HUWE1	1.87e-04	653	16	4	22586326
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	RFX7 YEATS2 SCAF1 NXF1 NFRKB	2.19e-04	1294	16	5	30804502
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	NELFA MED12 NFRKB	2.35e-04	268	16	3	33640491
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	YEATS2 SCAF1 NXF1 HUWE1 NFRKB	2.39e-04	1318	16	5	30463901
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	SCAF1 NELFA MED12 NXF1 NFRKB	2.47e-04	1327	16	5	32694731
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EIF4G3 SCAF1 MED12 NXF1 NFRKB	4.31e-04	1497	16	5	31527615
Interaction	PSMC3 interactions	EIF4G3 YEATS2 NXF1 HUWE1 NFRKB	1.47e-05	425	16	5	int:PSMC3
Interaction	POLR2H interactions	SCAF1 NELFA MED12 HUWE1	2.39e-05	223	16	4	int:POLR2H
Interaction	WDR37 interactions	EIF4G3 YEATS2 NXF1	3.01e-05	78	16	3	int:WDR37
Interaction	CDC16 interactions	YEATS2 SCAF1 MED12 NXF1	3.51e-05	246	16	4	int:CDC16
Interaction	POLR2A interactions	SCAF1 NELFA MED12 NXF1 HUWE1	4.47e-05	536	16	5	int:POLR2A
Interaction	RGPD5 interactions	CLEC11A NXF1 HUWE1	5.61e-05	96	16	3	int:RGPD5
Interaction	MBNL3 interactions	DAB1 NXF1	7.05e-05	16	16	2	int:MBNL3
Interaction	POLE3 interactions	YEATS2 NXF1 HUWE1	7.54e-05	106	16	3	int:POLE3
Interaction	BAG2 interactions	EIF4G3 YEATS2 MED12 HUWE1 NFRKB	9.07e-05	622	16	5	int:BAG2
Interaction	NUP43 interactions	EIF4G3 YEATS2 SCAF1 MED12 NFRKB	9.28e-05	625	16	5	int:NUP43
Interaction	SNRNP40 interactions	YEATS2 SCAF1 MED12 NXF1 NFRKB	1.02e-04	637	16	5	int:SNRNP40
Interaction	KYAT1 interactions	YEATS2 NXF1	1.11e-04	20	16	2	int:KYAT1
Interaction	POLR2C interactions	SCAF1 NELFA MED12 HUWE1	1.21e-04	338	16	4	int:POLR2C
Interaction	CDYL2 interactions	NXF1 HUWE1	1.48e-04	23	16	2	int:CDYL2
Interaction	POLR2I interactions	SCAF1 NELFA MED12	1.54e-04	135	16	3	int:POLR2I
Interaction	POLR2B interactions	SCAF1 NELFA MED12 HUWE1	1.73e-04	371	16	4	int:POLR2B
Interaction	FBXO38 interactions	YEATS2 NXF1 NFRKB	1.91e-04	145	16	3	int:FBXO38
Interaction	RFXANK interactions	RFX7 NXF1 HUWE1	1.95e-04	146	16	3	int:RFXANK
Interaction	POLR2J interactions	SCAF1 NELFA CLEC11A	2.19e-04	152	16	3	int:POLR2J
Interaction	CRYBG2 interactions	EIF4G3 YEATS2	2.37e-04	29	16	2	int:CRYBG2
Interaction	SUPT5H interactions	SCAF1 NELFA NXF1 NFRKB	2.48e-04	408	16	4	int:SUPT5H
Interaction	RGPD6 interactions	NXF1 HUWE1	3.08e-04	33	16	2	int:RGPD6
Interaction	ANKRA2 interactions	RFX7 HUWE1	3.27e-04	34	16	2	int:ANKRA2
Interaction	EPHB3 interactions	HUWE1 NFRKB	3.46e-04	35	16	2	int:EPHB3
Interaction	B4GALT4 interactions	CLEC11A NXF1	3.87e-04	37	16	2	int:B4GALT4
Interaction	WDR81 interactions	NXF1 HUWE1	4.30e-04	39	16	2	int:WDR81
Interaction	NOMO2 interactions	NXF1 HUWE1	4.76e-04	41	16	2	int:NOMO2
Cytoband	Ensembl 112 genes in cytogenetic band chr11q12	NXF1 CD5	6.30e-03	345	16	2	chr11q12
Coexpression	GSE40274_FOXP3_VS_FOXP3_AND_XBP1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN	EIF4G3 NELFA CD5	1.14e-04	158	16	3	M9147
Coexpression	GSE11386_NAIVE_VS_MEMORY_BCELL_DN	EIF4G3 RFX7 CD5	1.14e-04	158	16	3	M372
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	RFX7 YEATS2 TMEM245	1.67e-04	180	16	3	M8239
Coexpression	GSE22342_CD11C_HIGH_VS_LOW_DECIDUAL_MACROPHAGES_UP	EIF4G3 YEATS2 CABYR	2.21e-04	198	16	3	M8131
Coexpression	GSE36392_MAC_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP	MED12 NXF1 CD5	2.28e-04	200	16	3	M5285
Coexpression	GOLDRATH_NAIVE_VS_EFF_CD8_TCELL_UP	MED12 TMEM245 CD5	2.28e-04	200	16	3	M3035
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte-Chondrocyte_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DAB1 CLEC11A COL27A1	2.67e-05	166	16	3	37794a84601a2a949d579663d4a4bb8bc8fb5923
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DAB1 CLEC11A COL27A1	2.67e-05	166	16	3	81c546c6d847e49e662b81e71992ca0f7a99e890
ToppCell	IIH-Treg-proli_CD4\|IIH / Condition, Cell_class and T cell subcluster	YEATS2 SCAF1 NXF1	3.51e-05	182	16	3	5c7d02da9ca2bca49db9832704b6894dfaa08a71
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	DAB1 TMEM245 COL27A1	3.68e-05	185	16	3	1d874608aa2062024323512f68889219471b2f00
ToppCell	human_hepatoblastoma-Tumor_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	DAB1 TMEM245 COL27A1	4.18e-05	193	16	3	503a979328c68b096680b71359a26f02fafdff35
Drug	Nafronyl oxalate [3200-06-4]; Down 200; 8.4uM; MCF7; HT_HG-U133A	EIF4G3 RFX7 CABYR NFRKB	8.76e-06	195	16	4	2622_DN
Drug	Phenylpropanolamine hydrochloride [154-41-6]; Down 200; 21.4uM; HL60; HG-U133A	EIF4G3 NELFA CLEC11A NFRKB	9.12e-06	197	16	4	1602_DN
Drug	minocycline; Down 200; 10.5uM; MCF7; HT_HG-U133A_EA	RFX7 CABYR MED12 NFRKB	9.30e-06	198	16	4	1135_DN
Drug	tetrachlorobisphenol A	MED12 TMEM245	6.26e-05	17	16	2	CID000006619
Drug	AC1L3UEY	RFX7 MED12 HUWE1	6.36e-05	113	16	3	CID000122342
Disease	stem Cell Growth Factor beta measurement	DAB1 CLEC11A	6.55e-04	75	15	2	EFO_0008292
Disease	eosinophil percentage of leukocytes	EIF4G3 MUC2 CD5	5.84e-03	746	15	3	EFO_0007991

Protein segments in the cluster

Peptide	Gene	Start	Entry
PTTRPPPTTTPEPTA	CD5	141	P06127
TPKTTTPPSSPPPTA	CABYR	146	O75952
PPTPVTPVTPTTPAL	NFRKB	716	Q6P4R8
PTPAAPTSPLTPTTP	NELFA	386	Q9H3P2
PAPTPSSSPVPTLSP	NXF1	551	Q9UBU9
ITTPSPPTTTPSPPP	MUC2	1396	Q02817
PPTTTPSPPPTTTTT	MUC2	1401	Q02817
PSPPPTTTTTLPPTT	MUC2	1406	Q02817
TTTTTLPPTTTPSPP	MUC2	1411	Q02817
LPPTTTPSPPTTTTT	MUC2	1416	Q02817
TPSPPTTTTTTPPPT	MUC2	1421	Q02817
TPPPTTTPSPPITTT	MUC2	1431	Q02817
TTPSPPITTTTTPLP	MUC2	1436	Q02817
TTPLPTTTPSPPIST	MUC2	1446	Q02817
TTTPSPPISTTTTPP	MUC2	1451	Q02817
PPISTTTTPPPTTTP	MUC2	1456	Q02817
TTTPPPTTTPSPPTT	MUC2	1461	Q02817
PTTTPSPPTTTPSPP	MUC2	1466	Q02817
SPPTTTPSPPTTTPS	MUC2	1471	Q02817
TPSPPTTTPSPPTTT	MUC2	1476	Q02817
PPTTTTTTPPPTTTP	MUC2	1486	Q02817
TTTPPPTTTPSPPMT	MUC2	1491	Q02817
PTTTPSPPMTTPITP	MUC2	1496	Q02817
TLPPTTTPSPPTTTT	MUC2	1516	Q02817
TTPSPPTTTTTTPPP	MUC2	1521	Q02817
TTPPPTTTPSPPTTT	MUC2	1531	Q02817
TTTPSPPTTTPITPP	MUC2	1536	Q02817
PPTTTPITPPTSTTT	MUC2	1541	Q02817
PITPPTSTTTLPPTT	MUC2	1546	Q02817
TSTTTLPPTTTPSPP	MUC2	1551	Q02817
LPPTTTPSPPPTTTT	MUC2	1556	Q02817
TPSPPPTTTTTPPPT	MUC2	1561	Q02817
PTTTTTPPPTTTPSP	MUC2	1566	Q02817
TPPPTTTPSPPTTTT	MUC2	1571	Q02817
TTPSPPTTTTPSPPT	MUC2	1576	Q02817
PSPPTITTTTPPPTT	MUC2	1586	Q02817
ITTTTPPPTTTPSPP	MUC2	1591	Q02817
PPPTTTPSPPTTTTT	MUC2	1596	Q02817
TPSPPTTTTTTPPPT	MUC2	1601	Q02817
TPPPTTTPSPPTTTP	MUC2	1611	Q02817
TTPSPPTTTPITPPT	MUC2	1616	Q02817
STTTLPPTTTPSPPP	MUC2	1631	Q02817
PPTTTPSPPPTTTTT	MUC2	1636	Q02817
PSPPPTTTTTPPPTT	MUC2	1641	Q02817
TTTTTPPPTTTPSPP	MUC2	1646	Q02817
PPPTTTPSPPTTTTP	MUC2	1651	Q02817
TPSPPTTTTPSPPIT	MUC2	1656	Q02817
SPPITTTTTPPPTTT	MUC2	1666	Q02817
TTTTPPPTTTPSSPI	MUC2	1671	Q02817
PPTTTPSSPITTTPS	MUC2	1676	Q02817
PSSPITTTPSPPTTT	MUC2	1681	Q02817
PSPPPTTMTTPSPTT	MUC2	1721	Q02817
TPAPQPPTSSTPSTP	MED12	331	Q93074
TPTPPTAPTPVTSAP	HUWE1	3501	Q7Z6Z7
STPPDITSPPTPATP	DAB1	286	O75553
PPPSTRPLPPTTSSS	COL27A1	436	Q8IZC6
ITPSTVPSFPPTPPT	EIF4G3	406	O43432
TPTPSSGPSPSPTPE	CLEC11A	91	Q9Y240
SPSPSPSSSSPSPPP	SCAF1	196	Q9H7N4
TPIHTPTPTPTPTPT	RFX7	846	Q2KHR2
TPTPTPTPTPTPTSE	RFX7	856	Q2KHR2
PSPSSPSPTSPSPTL	TMEM245	321	Q9H330
PISTPSPSPLPRTPT	YEATS2	466	Q9ULM3