Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

RNF144B IRF2BP1 RGPD1 ZZEF1 HERC2 MED7 SMURF2 PML RGPD2 TRIM58 PIAS2 RFWD3 TRIM45 UHRF1 LONRF2

1.52e-0439824915GO:0061659
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

OBSCN PLEKHG5 RHOU DOCK5 HERC2 ARHGEF5 ARHGEF12 RAB3GAP1 ARHGEF1 KIAA1755 GDPGP1

1.61e-0423124911GO:0005085
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

RGPD1 OBSCN PLEKHG5 RHOU DOCK5 GBP5 HERC2 PLXNB1 RGPD2 ARHGEF5 ARHGEF12 TBC1D17 RAB3GAP1 ARHGEF1 KIAA1755 ARHGAP18 GDPGP1

2.26e-0450724917GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

RGPD1 OBSCN PLEKHG5 RHOU DOCK5 GBP5 HERC2 PLXNB1 RGPD2 ARHGEF5 ARHGEF12 TBC1D17 RAB3GAP1 ARHGEF1 KIAA1755 ARHGAP18 GDPGP1

2.26e-0450724917GO:0030695
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

RNF144B IRF2BP1 RGPD1 BCOR ZZEF1 HERC2 MED7 SMURF2 PML RGPD2 TRIM58 UBA3 PIAS2 RFWD3 TRIM45 UHRF1 LONRF2

2.53e-0451224917GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

RNF144B IRF2BP1 RGPD1 BCOR ZZEF1 HERC2 MED7 SMURF2 PML RGPD2 TRIM58 UBA3 PIAS2 RFWD3 TRIM45 UHRF1 LONRF2

3.93e-0453224917GO:0016755
GeneOntologyCellularComponentfilopodium tip

VIL1 FZD3 OSBPL3 EPHB1

7.57e-05202444GO:0032433
HumanPhenoAbnormal proportion of transitional B cells

PIK3CD PIK3R1 ARHGEF1

1.65e-054833HP:0030379
HumanPhenoIncreased proportion of transitional B cells

PIK3CD PIK3R1 ARHGEF1

1.65e-054833HP:0030381
HumanPhenoAbnormal macroscopic urine appearance

OBSCN NUP205 ATP11C NUP160 NPHS1 ANKFY1 NUP93

3.63e-0558837HP:0033072
MousePhenoincreased plasmacytoid dendritic cell number

ITGAX PLD4 SIK3 ARHGEF1

2.58e-05131994MP:0008524
MousePhenoincreased Ly6C-positive NK T cell number

RHOBTB1 SIK3 ARHGEF1

2.78e-0551993MP:0013679
DomainTPR-like_helical_dom

SART3 TTC21A RGPD1 IFIT5 TTC4 TRRAP SMYD4 TOMM70 HELZ RGPD2 ST13P4 AAR2 LONRF2

1.32e-0523324513IPR011990
DomainPHR

BTBD6 BTBD1 BTBD2

2.19e-0552453IPR012983
DomainPHR

BTBD6 BTBD1 BTBD2

2.19e-0552453PF08005
Domain-

CAND2 ARMC3 TRRAP ATXN10 BRAT1 ARMC7 RTTN RICTOR IPO4 SCYL2 HEATR6 AP4B1

3.87e-05222245121.25.10.10
DomainARM-type_fold

CAND2 ARMC3 TRRAP DOCK5 PIK3CD USP35 ATXN10 BRAT1 ARMC7 RTTN RICTOR IPO4 SCYL2 HEATR6 AP4B1

4.43e-0533924515IPR016024
DomainARM-like

CAND2 ARMC3 TRRAP USP35 ATXN10 BRAT1 ARMC7 RTTN RICTOR IPO4 SCYL2 HEATR6 AP4B1

6.12e-0527024513IPR011989
DomainCadherin_CS

CDH23 PCDHGB7 PCDHGB6 CELSR1 CELSR3 CELSR2 DSG4 PCDH9

9.50e-051092458IPR020894
DomainCADHERIN_1

CDH23 PCDHGB7 PCDHGB6 CELSR1 CELSR3 CELSR2 DSG4 PCDH9

1.22e-041132458PS00232
DomainCadherin

CDH23 PCDHGB7 PCDHGB6 CELSR1 CELSR3 CELSR2 DSG4 PCDH9

1.22e-041132458PF00028
Domain-

CDH23 PCDHGB7 PCDHGB6 CELSR1 CELSR3 CELSR2 DSG4 PCDH9

1.30e-0411424582.60.40.60
DomainCADHERIN_2

CDH23 PCDHGB7 PCDHGB6 CELSR1 CELSR3 CELSR2 DSG4 PCDH9

1.30e-041142458PS50268
DomainCA

CDH23 PCDHGB7 PCDHGB6 CELSR1 CELSR3 CELSR2 DSG4 PCDH9

1.38e-041152458SM00112
DomainCadherin-like

CDH23 PCDHGB7 PCDHGB6 CELSR1 CELSR3 CELSR2 DSG4 PCDH9

1.47e-041162458IPR015919
DomainUbiquitin-rel_dom

PLEKHG5 AXIN2 PIK3CD AFDN USP47 FRMD6 UHRF1 FRMPD3 GABPA FRMD3

1.64e-0418424510IPR029071
DomainCadherin

CDH23 PCDHGB7 PCDHGB6 CELSR1 CELSR3 CELSR2 DSG4 PCDH9

1.65e-041182458IPR002126
DomainPH_dom-like

SPTBN2 RGPD1 OBSCN PLEKHG5 PLEKHH3 OSBPL7 RGPD2 ARHGEF5 ARHGEF12 DOK4 FRMD6 OSBPL3 ARHGEF1 DNM3 FRMPD3 FRMD3

1.69e-0442624516IPR011993
DomainUCR_hinge

UQCRH UQCRHL

1.71e-0422452PF02320
DomainUbol_cytC_Rdtase_hinge_dom

UQCRH UQCRHL

1.71e-0422452IPR023184
Domain-

UQCRH UQCRHL

1.71e-04224521.10.287.20
DomainCyt_b-c1_6

UQCRH UQCRHL

1.71e-0422452IPR003422
DomainTPR_1

TTC21A RGPD1 IFIT5 TTC4 TOMM70 ST13P4 LONRF2

1.82e-04902457IPR001440
DomainTPR_1

TTC21A RGPD1 IFIT5 TTC4 TOMM70 ST13P4 LONRF2

1.82e-04902457PF00515
Domain-

SPTBN2 RGPD1 OBSCN PLEKHG5 PLEKHH3 OSBPL7 RGPD2 ARHGEF5 ARHGEF12 DOK4 FRMD6 OSBPL3 ARHGEF1 DNM3 FRMD3

2.15e-04391245152.30.29.30
DomainTPR

TTC21A RGPD1 IFIT5 TTC4 TOMM70 RGPD2 ST13P4 LONRF2

3.05e-041292458SM00028
DomainBTB

BTBD6 BTBD1 RHOBTB1 KLHL18 ANKFY1 ZBTB47 BTBD2 KLHL25

3.38e-041312458PF00651
DomainGAIN_dom_N

CELSR1 CELSR3 CELSR2

3.40e-04112453IPR032471
DomainGAIN

CELSR1 CELSR3 CELSR2

3.40e-04112453PF16489
Domain-

TTC21A RGPD1 IFIT5 TTC4 TRRAP SMYD4 TOMM70 HELZ RGPD2 LONRF2

4.21e-04207245101.25.40.10
DomainRGS-like_dom

ARHGEF12 ARHGEF1

5.10e-0432452IPR015212
DomainRGS-like

ARHGEF12 ARHGEF1

5.10e-0432452PF09128
DomainGABAAb_rcpt

GABRB1 GABRB3

5.10e-0432452IPR002289
DomainBTB

BTBD6 BTBD1 RHOBTB1 KCNC1 KLHL18 ANKFY1 ZBTB47 BTBD2 KLHL25

6.35e-041802459SM00225
DomainBTB/POZ_dom

BTBD6 BTBD1 RHOBTB1 KCNC1 KLHL18 ANKFY1 ZBTB47 BTBD2 KLHL25

7.72e-041852459IPR000210
DomainTPR-contain_dom

TTC21A RGPD1 IFIT5 TTC4 TOMM70 RGPD2 ST13P4 LONRF2

8.31e-041502458IPR013026
DomainSKP1/BTB/POZ

BTBD6 BTBD1 RHOBTB1 KCNC1 KLHL18 ANKFY1 ZBTB47 BTBD2 KLHL25

8.98e-041892459IPR011333
DomainLaminin_G

GAS6 COL22A1 CELSR1 CELSR3 CELSR2

9.70e-04582455IPR001791
DomainBACK

BTBD6 BTBD1 KLHL18 BTBD2 KLHL25

1.13e-03602455SM00875
DomainPH

SPTBN2 OBSCN PLEKHG5 PLEKHH3 OSBPL7 ARHGEF5 ARHGEF12 DOK4 OSBPL3 ARHGEF1 DNM3

1.16e-0327824511SM00233
DomainPH_DOMAIN

SPTBN2 OBSCN PLEKHG5 PLEKHH3 OSBPL7 ARHGEF5 ARHGEF12 DOK4 OSBPL3 ARHGEF1 DNM3

1.19e-0327924511PS50003
DomainBACK

BTBD6 BTBD1 KLHL18 BTBD2 KLHL25

1.22e-03612455IPR011705
DomainBACK

BTBD6 BTBD1 KLHL18 BTBD2 KLHL25

1.22e-03612455PF07707
DomainPH_domain

SPTBN2 OBSCN PLEKHG5 PLEKHH3 OSBPL7 ARHGEF5 ARHGEF12 DOK4 OSBPL3 ARHGEF1 DNM3

1.23e-0328024511IPR001849
DomainBTB

BTBD6 BTBD1 RHOBTB1 KLHL18 ANKFY1 ZBTB47 BTBD2 KLHL25

1.26e-031602458PS50097
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

RGPD1 SMC5 NUP205 HERC2 NUP160 PML RGPD2 PIAS2 NUP93

1.31e-06841829MM14929
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

RGPD1 NUP205 NUP160 PML RGPD2 PIAS2 NUP93

2.17e-06471827MM14939
PathwayREACTOME_RHOD_GTPASE_CYCLE

ADD3 PIK3R1 HINT2 GOLGA2 PLXNA1 PLXNB1 ANKFY1

1.78e-05641827MM15601
PathwayREACTOME_RHOD_GTPASE_CYCLE

ADD3 PIK3R1 HINT2 PLXNA1 PLXNB1 ANKFY1

5.92e-05531826M41811
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

SMC5 NUP205 HERC2 NUP160 PML PIAS2 NUP93

5.98e-05771827M27226
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

NUP205 NUP160 PML PIAS2 NUP93

1.37e-04391825M27238
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

RGPD1 NUP205 NUP160 RGPD2 NUP93

1.55e-04401825MM14945
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

RGPD1 NUP205 NUP160 RGPD2 NUP93

1.75e-04411825MM15200
PathwayREACTOME_RHO_GTPASE_CYCLE

OBSCN PLEKHG5 RHOU ADD3 DOCK5 RHOBTB1 PIK3R1 HINT2 GOLGA2 PLXNA1 PLXNB1 ANKFY1 ARHGEF5 ARHGEF12 ARHGEF1 ARHGAP18

1.84e-0443918216MM15595
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

RGPD1 NUP205 NUP160 RGPD2 PIAS2 NUP93

1.87e-04651826MM15147
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

RGPD1 NUP205 NUP160 RGPD2 NUP93

1.96e-04421825MM15039
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

RGPD1 NUP205 NUP160 RGPD2 NUP93

2.20e-04431825MM14609
PathwayREACTOME_RHO_GTPASE_CYCLE

OBSCN PLEKHG5 RHOU ADD3 DOCK5 RHOBTB1 PIK3R1 HINT2 CDC42EP5 PLXNA1 PLXNB1 ANKFY1 ARHGEF5 ARHGEF12 ARHGEF1 ARHGAP18

2.43e-0445018216M27078
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

RGPD1 OBSCN NUF2 PLEKHG5 RHOU ADD3 DOCK5 RHOBTB1 PIK3R1 HINT2 NUP160 GOLGA2 PLXNA1 PLXNB1 RGPD2 ANKFY1 ARHGEF5 ARHGEF12 ARHGEF1 ARHGAP18

2.76e-0464918220MM15690
PathwayREACTOME_SUMOYLATION

RGPD1 SMC5 NUP205 HERC2 NUP160 PML RGPD2 PIAS2 NUP93

3.48e-041691829MM14919
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

SART3 ATRX PFAS ZZEF1 DOCK5 SMYD4 TOMM70 CARD6 HELZ AFDN GOLGA2 PLXNB1 SLC27A4 RBL1 ARHGEF5 RICTOR SIK3 PAPSS2 TBC1D17 RFWD3 ARNT OSBPL3 ARHGEF1 AP4B1 FIGNL1 ZC3HAV1 RAVER1

3.37e-136502512738777146
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PALD1 NDOR1 OBSCN PFAS ZZEF1 TRRAP PLEKHG5 AHDC1 PLEKHH3 MDN1 PER2 PIK3CD HERC2 BRAT1 SMURF2 PLXNA1 RTTN TRMT1 GRIN2D MED13L TBC1D17 CELSR1 SCAP KLHL25 KANSL1 CELSR3 CELSR2 DOK4 HELZ2 OGDHL ZFYVE26 IL17RD ESPL1

6.05e-1211052513335748872
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

ERCC1 ATRX ERC1 SPTBN2 IFIT5 BTBD1 ADD3 STXBP1 ADAMTS9 NFE2L2 PIK3R1 GLUL AFDN ATXN10 SMPD3 HERC2 SMURF2 USP47 BRWD1 ZBTB47 UBA3 BTBD2 MED13L PIAS2 SCYL2 HEATR6 CELSR3 PDE4DIP DNM3 LRP2 EXOC1 ATP2A2

1.24e-0912852513235914814
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

SART3 ATRX ERC1 PFAS NUF2 TTC4 TRRAP NUP205 CDAN1 PIK3R1 AFDN ATXN10 HERC2 MED7 NUP160 SLC27A4 VIL1 KRT78 KRT82 UBA3 IPO4 PAPSS2 AZIN1 FRMD6 OSBPL3 NUP93 LTF AP4B1 ATP2A2

6.49e-0812842512917353931
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

PRAMEF5 CAND2 ATRX OBSCN BCOR PRDM2 WWC2 PIK3CD FMN1 PIK3R1 TSTD2 PLXNB1 PRAMEF6 PML BRWD1 RICTOR CUBN SCAP OSBPL3 ARHGEF1 TLR4 LRP2 OGDHL ACCSL IL17RD ESPL1

1.03e-0710842512611544199
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

SART3 PALD1 CAND2 IRF2BP1 ATRX ERC1 TTC21A CDH23 STYXL2 BCKDHB NUF2 NUP205 DOCK5 PIK3R1 HELZ AFDN ATXN10 VPS51 NUP160 RBL1 IPO4 AAR2 SCYL2 OSBPL3 EXOC1 VPS53 PCDH9 ZC3HAV1 RAVER1

1.18e-0713212512927173435
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

ZZEF1 TRRAP ALMS1 HELZ NUP160 PLXNA1 KRT82 RTTN ARHGEF12 CELSR3 ARHGEF1

1.32e-071872511126460568
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

SART3 ERC1 SPTBN2 PFAS PLEKHG5 OSBPL7 PML BRWD1 ABCC1 TPCN2 TRMT1 RAD9B IPO4 KHDC4 TBC1D17 USP6 TRMT44 MZF1 ARHGEF1 CD44 UHRF1 MSLN ZC3HAV1

3.13e-079252512328986522
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

SART3 SPTBN2 PFAS TRRAP NUP205 MDN1 HELZ AFDN HERC2 NUP160 USP47 WDR36 NVL IPO4 HELZ2 NUP93 LTF ATP2A2 ZC3HAV1

3.42e-076532511922586326
Pubmed

The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development.

CELSR1 CELSR3 CELSR2

3.71e-073251311677057
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

IRF2BP1 ERC1 PFAS COL22A1 TRRAP NUP205 DOCK5 TOMM70 RHOBTB1 BRCA2 EDARADD NUP160 GOLGA2 ABCC1 RBL1 SCAP CD44 NUP93 LTF PCDH9

7.10e-077542512035906200
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SPTBN2 PFAS SMYD4 RHOBTB1 ALMS1 ADAMTS9 KLHL18 NUP160 BAZ2B RICTOR MON1B KHDC4 RAB3GAP1 SCAP OSBPL3 HELZ2

7.22e-074932511615368895
Pubmed

A dual role for planar cell polarity genes in ciliated cells.

FZD3 CELSR1 CELSR3 CELSR2

8.40e-0711251425024228
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

SPTBN2 PFAS MDN1 ALMS1 PER2 HERC2 ARHGEF12 ZFYVE26

9.33e-0710425189205841
Pubmed

Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice.

FZD3 CELSR1 CELSR3 CELSR2

1.25e-0612251420631168
Pubmed

Abolishment of proximal tubule albumin endocytosis does not affect plasma albumin during nephrotic syndrome in mice.

NDOR1 CUBN LRP2

1.48e-064251329032953
Pubmed

The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.

CELSR1 CELSR3 CELSR2

1.48e-064251337224017
Pubmed

Developmental expression profiles of Celsr (Flamingo) genes in the mouse.

CELSR1 CELSR3 CELSR2

1.48e-064251311850187
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

ERC1 SPTBN2 RGPD1 BCOR HCN2 MDN1 GLUL AFDN HERC2 GOLGA2 RGPD2 ANKFY1 ARHGEF12 GRIN2D SIK3 IPO4 CELSR2 OSBPL3 SPHKAP PDE4DIP DNM3 FRMPD3

2.29e-069632512228671696
Pubmed

A non-autonomous function of the core PCP protein VANGL2 directs peripheral axon turning in the developing cochlea.

FZD3 CELSR1 CELSR3 CD44

2.50e-0614251429784671
Pubmed

HENA, heterogeneous network-based data set for Alzheimer's disease.

NUF2 ALMS1 HERC2 NUP160 CASS4 KANSL1 PDE4DIP EXOC1

2.76e-06120251831413325
Pubmed

A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.

BTBD6 CAND2 BTBD1 RHOBTB1 KLHL18 BTBD2 KLHL25

3.35e-0687251737495603
Pubmed

Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.

FZD3 CELSR1 CELSR3 CELSR2

3.40e-0615251420473291
Pubmed

Planar cell polarity pathway regulates nephrin endocytosis in developing podocytes.

NPHS1 FZD3 CELSR2

3.67e-065251323824190
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

SART3 ERCC1 ATRX TRRAP NUP205 HERC2 NUP160 PML WDR36 NVL RICTOR NUP93 ESPL1 ZC3HAV1

4.52e-064402511434244565
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

CAND2 ERC1 BTBD1 NUP205 TOMM70 ATXN10 UQCRH VPS51 BRAT1 SLC27A4 ABCC1 IPO4 AAR2 RAB3GAP1 SCAP ARHGEF1 NUP93 ESPL1 ATP2A2 VPS53 RAVER1

5.70e-069422512131073040
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SART3 ATRX ARMC3 ERC1 SPTBN2 RGPD1 ANKRD30B IFIT5 NUP205 MDN1 STXBP1 ATP11C UQCRH SMURF2 UQCRHL SLC27A4 VIL1 RGPD2 PCDHGB7 PCDHGB6 ATP6V1G1 AAR2 DOK4 OGDHL ATP2A2 PCK1 GABPA

6.59e-0614422512735575683
Pubmed

Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption.

NDOR1 SIK3 CSF1R

7.31e-066251334160349
Pubmed

Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.

USP35 VPS51 USP47 RICTOR RFWD3 USP6 HELZ2 VPS53

1.24e-05147251829576527
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

PALD1 NUF2 ZZEF1 TTC4 TOMM70 MDN1 ALMS1 PIK3R1 HINT2 ATXN10 HERC2 NUP160 USP47 WDR36 FASTKD1 TRMT1 TBC1D17 SCYL2 RAB3GAP1 OSBPL3 LRP2 OGDHL ESPL1 ATP2A2 FIGNL1 ZC3HAV1 RAVER1

1.27e-0514962512732877691
Pubmed

Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues.

CELSR1 CELSR3 CELSR2

1.27e-057251317937400
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

PRAMEF5 CAND2 CDH23 TRRAP RHOU SMYD4 MDN1 GBP5 COG6 YDJC ATXN10 VPS51 KLHL18 PRAMEF6 ARMC7 SIK3 PIAS2 LRRC8D ZFYVE28 TRIM45 OSBPL3 ARHGEF1 ARHGAP18 VPS53

1.33e-0512422512430973865
Pubmed

Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease.

NPHS1 VIL1 CUBN LRP2

1.44e-0521251427591083
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

SART3 PALD1 CAND2 IRF2BP1 SPTBN2 NUP205 TOMM70 MDN1 COG6 UQCRH SLC27A4 PML ABCC1 WDR36 ING5 IPO4 RAB3GAP1 CD44 EXOC1 NUP93 LTF ATP2A2 VPS53 FIGNL1 ZC3HAV1 RAVER1

1.84e-0514402512630833792
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

IRF2BP1 RGPD1 BCOR MDN1 STXBP1 UQCRH USP47 ANKFY1 SIK3 PIAS2 USP6 RAB3GAP1 DSG4 IL17RD DNAH11 RAVER1

1.87e-056382511631182584
Pubmed

Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.

PCDHGB7 PCDHGB6 CELSR1 CELSR3 CELSR2 PCDH9

2.56e-0580251610716726
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

ATRX BCOR TRRAP AHDC1 PRDM2 DOCK5 MDN1 NFE2L2 UQCRH SLC27A4 ABCC1 WDR36 BAZ2B ING5 RFWD3 INTS10 ARNT KANSL1 OSBPL3 UHRF1 NUP93 ATP2A2 ZC3HAV1 RAVER1

2.57e-0512942512430804502
Pubmed

Genetic Steroid-Resistant Nephrotic Syndrome Overview

NUP160 NPHS1 NUP93

3.02e-059251334436835
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

GABRB1 GABRB3 SART3 ERC1 RGPD1 ADD3 STXBP1 GLUL HELZ AFDN VPS51 RGPD2 ATP6V1G1 RICTOR RAB3GAP1 CELSR2 SPHKAP IGHMBP2 PDE4DIP EXOC1 ATP2A2 ELP4

3.10e-0511392512236417873
Pubmed

Identification of host proteins required for HIV infection through a functional genomic screen.

TOMM70 MDN1 MED7 NUP160 TRIM58 ARHGEF12 LRRC8D USP6 IGHMBP2 VPS53

3.18e-052722511018187620
Pubmed

A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.

BTBD1 NFE2L2 PIK3R1 ARHGEF5 ARHGEF12 BTBD2

3.38e-0584251634591642
Pubmed

Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos.

AXIN2 CELSR1 CELSR3 CELSR2

3.49e-0526251437228654
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

ERC1 TOMM70 MDN1 HERC2 BRAT1 GOLGA2 SLC27A4 ABCC1 WDR36 FASTKD1 NVL TRMT1 SIK3 AAR2 HEATR6 IGHMBP2 PDE4DIP

3.93e-057542511733060197
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

ERC1 SMC5 ALMS1 ANKFY1 SIK3 MED13L SCAP HELZ2 DNM3

4.12e-05225251912168954
Pubmed

Celsr3 is required in motor neurons to steer their axons in the hindlimb.

FZD3 CELSR3 CELSR2

4.29e-0510251325108913
Pubmed

Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation.

ATP6V1B1 STXBP1 GOLGA2 SCYL2 DNM3

4.46e-0554251525496667
Pubmed

Defining the membrane proteome of NK cells.

NUF2 ITGAX NUP205 TOMM70 MDN1 GBP5 PIK3R1 HELZ ATXN10 HERC2 BRAT1 SLC27A4 ABCC1 NVL IPO4 LRRC8D OSBPL3 IGHMBP2 HELZ2 EXOC1 NUP93 MCTP2

4.50e-0511682512219946888
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PALD1 ERC1 SMC5 TOMM70 PER2 ANKFY1 ARHGEF12 MED13L KANSL1 SPHKAP PDE4DIP DNM3

4.57e-054072511212693553
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

IRF2BP1 TRRAP STXBP1 ATXN10 WDR36 NVL HEATR6 ARHGEF1 DNM3 UHRF1 ATP2A2 VPS53

4.91e-054102511226949251
Pubmed

VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.

TTC4 NUP205 MDN1 ATXN10 BRAT1 VIL1 RAB3GAP1 DNM3 ESPL1 VPS53

5.14e-052882511023383273
Pubmed

Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains.

NFE2L2 TLR4

5.19e-052251231717470
Pubmed

Knockout of the Complex III subunit Uqcrh causes bioenergetic impairment and cardiac contractile dysfunction.

UQCRH UQCRHL

5.19e-052251236565314
Pubmed

Epileptic encephalopathy de novo GABRB mutations impair γ-aminobutyric acid type A receptor function.

GABRB1 GABRB3

5.19e-052251226950270
Pubmed

Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential.

ARHGEF12 ARHGEF1

5.19e-052251214712228
Pubmed

Discovery of rare coding variants in OGDHL and BRCA2 in relation to breast cancer risk in Chinese women.

BRCA2 OGDHL

5.19e-052251231837001
Pubmed

Wogonin reverses multi-drug resistance of human myelogenous leukemia K562/A02 cells via downregulation of MRP1 expression by inhibiting Nrf2/ARE signaling pathway.

NFE2L2 ABCC1

5.19e-052251225264278
Pubmed

Expression and immunolocalisation of the endocytic receptors megalin and cubilin in the human yolk sac and placenta across gestation.

CUBN LRP2

5.19e-052251223978537
Pubmed

Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α.

PIK3CD PIK3R1

5.19e-052251221827948
Pubmed

Nrf2 pathway regulates multidrug-resistance-associated protein 1 in small cell lung cancer.

NFE2L2 ABCC1

5.19e-052251223667609
Pubmed

Chromosomal localization of Celsr2 and Celsr3 in the mouse; Celsr3 is a candidate for the tippy (tip) lethal mutant on chromosome 9.

CELSR3 CELSR2

5.19e-052251210790539
Pubmed

Genetic defects in PI3Kδ affect B-cell differentiation and maturation leading to hypogammaglobulineamia and recurrent infections.

PIK3CD PIK3R1

5.19e-052251228104464
Pubmed

Acute endotoxemia in mice induces downregulation of megalin and cubilin in the kidney.

CUBN LRP2

5.19e-052251222437417
Pubmed

Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains.

PLXNA1 PLXNB1

5.19e-052251212559962
Pubmed

Phosphatidylinositol 3-kinase is required for the transcriptional activation of cyclin D2 in BCR activated primary mouse B lymphocytes.

PIK3CD PIK3R1

5.19e-052251216114097
Pubmed

Celsr3 is required for Purkinje cell maturation and regulates cerebellar postsynaptic plasticity.

FZD3 CELSR3

5.19e-052251234308297
Pubmed

Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryo.

CUBN LRP2

5.19e-052251215616221
Pubmed

Hyaluronan fragments/CD44 mediate oxidative stress-induced MUC5B up-regulation in airway epithelium.

MUC5B CD44

5.19e-052251218757307
Pubmed

Celsr3 and Fzd3 in axon guidance.

FZD3 CELSR3

5.19e-052251225813877
Pubmed

Silencing Nrf2 attenuates chronic suppurative otitis media by inhibiting pro-inflammatory cytokine secretion through up-regulating TLR4.

NFE2L2 TLR4

5.19e-052251232579053
Pubmed

E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells.

BRCA2 RFWD3

5.19e-052251232391871
Pubmed

Multiple modes for conferring surface expression of homomeric beta1 GABAA receptors.

GABRB1 GABRB3

5.19e-052251218650446
Pubmed

Adipose-derived mesenchymal stem cells promote the survival of fat grafts via crosstalk between the Nrf2 and TLR4 pathways.

NFE2L2 TLR4

5.19e-052251227607584
Pubmed

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency.

PIK3CD PIK3R1

5.19e-052251224165795
Pubmed

Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24.

BTBD1 BTBD2

5.19e-052251211179693
Pubmed

Plexin signaling hampers integrin-based adhesion, leading to Rho-kinase independent cell rounding, and inhibiting lamellipodia extension and cell motility.

PLXNA1 PLXNB1

5.19e-052251214734633
Pubmed

Characterization of an epithelial approximately 460-kDa protein that facilitates endocytosis of intrinsic factor-vitamin B12 and binds receptor-associated protein.

CUBN LRP2

5.19e-05225129334227
Pubmed

PI3Kδ inhibitors in cancer: rationale and serendipity merge in the clinic.

PIK3CD PIK3R1

5.19e-052251222586681
Pubmed

Silencing megalin and cubilin genes inhibits myeloma light chain endocytosis and ameliorates toxicity in human renal proximal tubule epithelial cells.

CUBN LRP2

5.19e-052251218448595
Pubmed

The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein.

PML UHRF1

5.19e-052251222945642
Pubmed

Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit.

OBSCN PIK3R1

5.19e-052251227323778
Pubmed

The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development.

NDOR1 RICTOR

5.19e-052251233027655
Pubmed

Hyaluronate-CD44 interactions can induce murine B-cell activation.

TLR4 CD44

5.19e-05225129108410
Pubmed

Nrf2 Regulates the Sensitivity of Mouse Keratinocytes to Nitrogen Mustard via Multidrug Resistance-Associated Protein 1 (Mrp1).

NFE2L2 ABCC1

5.19e-052251226454883
Pubmed

Deregulation of the planar cell polarity genes CELSR3 and FZD3 in Hirschsprung disease.

FZD3 CELSR3

5.19e-052251227619161
Pubmed

LOSS of Mrp1 alters detoxification enzyme expression in a tissue- and hormonal-status-specific manner.

NFE2L2 ABCC1

5.19e-052251222522787
Pubmed

Germline-activating mutations in PIK3CD compromise B cell development and function.

PIK3CD PIK3R1

5.19e-052251230018075
Pubmed

Polymorphisms in LRP2 and CUBN genes and their association with serum vitamin D levels and sleep apnea.

CUBN LRP2

5.19e-052251238008818
Pubmed

Megalin and cubilin in the human gallbladder epithelium.

CUBN LRP2

5.19e-052251218791690
Pubmed

Control of antioxidative response by the tumor suppressor protein PML through regulating Nrf2 activity.

NFE2L2 PML

5.19e-052251224943846
Pubmed

Megalin and cubilin: multifunctional endocytic receptors.

CUBN LRP2

5.19e-052251211994745
Pubmed

Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins.

CUBN LRP2

5.19e-052251210766831
Pubmed

Flavonoids protect cerebrovascular endothelial cells through Nrf2 and PI3K from β-amyloid peptide-induced oxidative damage.

NFE2L2 PIK3R1

5.19e-052251222272764
Pubmed

A Novel Murine Anti-Lactoferrin Monoclonal Antibody Activates Human Polymorphonuclear Leukocytes through Membrane-Bound Lactoferrin and TLR4.

TLR4 LTF

5.19e-052251226649297
Pubmed

Cubilin and megalin expression and their interaction in the rat intestine: effect of thyroidectomy.

CUBN LRP2

5.19e-052251211595644
Pubmed

Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking.

CELSR1 CELSR2

5.19e-052251223292348
Pubmed

PI3K contributed to modulation of spinal nociceptive information related to ephrinBs/EphBs.

PIK3R1 EPHB1

5.19e-052251222879882
Pubmed

Case Study: Mechanism for Increased Follicular Helper T Cell Development in Activated PI3K Delta Syndrome.

PIK3CD PIK3R1

5.19e-052251231031754
Pubmed

Dietary flavonoid (-)epicatechin stimulates phosphatidylinositol 3-kinase-dependent anti-oxidant response element activity and up-regulates glutathione in cortical astrocytes.

NFE2L2 PIK3R1

5.19e-052251218624917
Pubmed

In vitro methylation of nuclear respiratory factor-2 binding sites suppresses the promoter activity of the human TOMM70 gene.

TOMM70 GABPA

5.19e-052251218852034
Pubmed

GABAA receptors involved in sleep and anaesthesia: β1- versus β3-containing assemblies.

GABRB1 GABRB3

5.19e-052251221735059
InteractionTOP3B interactions

PALD1 NDOR1 SPTBN2 OBSCN PFAS ZZEF1 TRRAP PLEKHG5 AHDC1 PLEKHH3 AXIN2 MDN1 PER2 FASTK PIK3CD HELZ HERC2 BRAT1 SMURF2 PLXNA1 WDR36 RTTN TRMT1 GRIN2D MED13L IPO4 TBC1D17 CELSR1 SCAP KLHL25 KANSL1 CELSR3 CELSR2 DOK4 HELZ2 OGDHL ZFYVE26 IL17RD ESPL1 ZC3HAV1

1.40e-06147024640int:TOP3B
InteractionZBBX interactions

ZZEF1 FZD3 TBC1D17 CELSR1 CELSR2 DNM3

1.77e-06312466int:ZBBX
InteractionSCN2B interactions

CAND2 MDN1 COG6 ATP11C NUP160 FASTKD1 IPO4 DNM3 EXOC1

2.45e-06952469int:SCN2B
InteractionDUSP16 interactions

NUF2 ALMS1 BRCA2 COG6 HELZ VPS51 RICTOR SIK3 RAB3GAP1 SHROOM1 ARHGEF1 ESPL1 FIGNL1

7.42e-0623724613int:DUSP16
InteractionTACSTD2 interactions

ATP6V1B1 CAND2 BTBD1 MDN1 NUP160 RTTN FASTKD1 HEATR6 CELSR2

2.99e-051292469int:TACSTD2
InteractionHRAS interactions

TTC21A ADD3 DOCK5 PIK3CD PIK3R1 TRPV2 AFDN VPS51 PLXNA1 PLXNB1 ABCC1 DUS4L RICTOR GRIN2D BTBD2 LRRC8D HEATR6 CELSR2 ARHGEF1 CD44 EXOC1 DCUN1D3 PCDH9

3.00e-0572524623int:HRAS
InteractionCLOCK interactions

NUF2 TRRAP PER2 VPS51 KHDC4 ARNT EXOC1 VPS53

3.59e-051022468int:CLOCK
InteractionGUSBP5 interactions

NUF2 BCOR ALMS1 BRCA2 HELZ RICTOR RAB3GAP1

3.63e-05752467int:GUSBP5
Cytoband1p36.21

PRAMEF5 AADACL4 PRDM2 UQCRHL PRAMEF6 TMEM82

1.35e-066325261p36.21
Cytoband20q13.31

FAM209B CASS4 PCK1

8.68e-0516252320q13.31
Cytoband3p21.31

KLHL18 PLXNB1 SCAP CELSR3 LTF

2.36e-0410025253p21.31
GeneFamilyAdhesion G protein-coupled receptors, subfamily C|CELSR cadherins

CELSR1 CELSR3 CELSR2

8.61e-0731733913
GeneFamilyAdhesion G protein-coupled receptors, subfamily C|CELSR cadherins

CELSR1 CELSR3 CELSR2

8.61e-07317331189
GeneFamilyBasic leucine zipper proteins|BTB domain containing

BTBD6 BTBD1 RHOBTB1 KLHL18 ANKFY1 ZBTB47 BTBD2 KLHL25

4.47e-051341738861
GeneFamilyUPF1 like RNA helicases

HELZ IGHMBP2 HELZ2

1.34e-041117331169
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

TTC21A RGPD1 IFIT5 TTC4 TOMM70 RGPD2

8.37e-041151736769
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

PLEKHH3 FRMD6 FRMPD3 FRMD3

1.32e-035017341293
GeneFamilyPlexins

PLXNA1 PLXNB1

3.14e-0391732683
GeneFamilyZinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors

ANKFY1 ZFYVE28 ZFYVE26

3.18e-0331173381
GeneFamilyNucleoporins

NUP205 NUP160 NUP93

3.48e-033217331051
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

OBSCN ARHGEF5 ARHGEF12 ARHGEF1

3.68e-03661734722
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

SPTBN2 PLEKHG5 PLEKHH3 OSBPL7 DOK4 OSBPL3 DNM3

3.73e-032061737682
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

GABRB3 ATRX CHRM5 AHDC1 PRDM2 MDN1 STXBP1 KCNC1 PIK3CD CACNA1I SMPD3 ST8SIA4 PLXNA1 BRWD1 TRIM58 ARHGEF12 RICTOR SIK3 MED13L PIAS2 CELSR3 DOK4 PDE4DIP DNM3 OGDHL FRMPD3 LONRF2 VPS53 PCDH9 FRMD3 EPHB1

9.32e-08110625131M39071
ToppCellLPS-IL1RA-Epithelial_airway|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARMC3 SPINT1 KRT78 MUC5B LRRC46 CELSR1 OSBPL3 MSLN DNAH11

3.46e-071612519472c354f5ee148b37a5dfb795e83348ecb1643f1
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V1B1 SPTBN2 EDARADD TMEM117 PAPSS2 LRRC9 OGDHL ARHGAP18 LONRF2

4.05e-071642519d847d509bb1791638032ade6755d8164586b5bd5
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDH23 NUF2 RHOU RBL1 RFWD3 SCYL2 MZF1 LTF FIGNL1

5.75e-071712519913bae728b5e653771a27c79a309eb023699f1d0
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDH23 NUF2 RHOU RBL1 RFWD3 SCYL2 MZF1 LTF FIGNL1

5.75e-071712519f28b2336057e353b96a6ff4581ec9fd0ca0789d9
ToppCellnormal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells|normal_Lymph_Node / Location, Cell class and cell subclass

GAS6 LRRC69 SMPD3 PLD4 FZD3 MED13L USP6 CSF1R EPHB1

6.98e-07175251929fbdfe1d3bfcb063be2bced0128a33176c5b78f
ToppCellIIH-CD8-CD4_Treg|IIH / Condition, Cell_class and T cell subcluster

IRF2BP1 NAGS BRCA2 FASTK FAM209B BRAT1 AAR2 OSBPL3 IGHMBP2

8.84e-071802519d1a8b25115c80e5a5bd0b8244167a98250ab9778
ToppCellCOVID-19-kidney-Macrophages|COVID-19 / Disease (COVID-19 only), tissue and cell type

ITGAX GBP5 FMN1 GLUL ST8SIA4 CCDC170 CSF1R CD44 ARHGAP18

1.87e-0619725193912301018d0863144dcfac8d1fa8adc081748d7
ToppCellmyeloid-pro-pDC|World / Lineage and Cell class

PALD1 ERCC1 GAS6 BRCA2 SMPD3 KCNK17 PLD4 UHRF1 EPHB1

1.87e-0619725198918ee006b16f6b86ed33ce1dd5c0f01f51f88f5
ToppCellCOVID-19-lung|COVID-19 / Disease (COVID-19 only), tissue and cell type

ITGAX FMN1 GLUL SMURF2 PAPSS2 CD44 ARHGAP18 MCTP2 ZC3HAV1

2.03e-061992519155b03b859157013e9142e9248551369127d9204
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ATRX PLEKHG5 ADD3 STXBP1 AFDN BRWD1 BAZ2B ARHGEF12 ARHGAP18

2.11e-062002519dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARMC3 CCDC170 KRT78 MUC5B LRRC9 LRRC46 MSLN DNAH11

4.33e-061642518e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCellmetastatic_Brain-Myeloid_cells-pDCs|metastatic_Brain / Location, Cell class and cell subclass

GAS6 HCN2 SMPD3 KCNK17 PLD4 TRIM58 LONRF2 EPHB1

4.33e-06164251806db4cc064f0765c481ce880207823872c27bfa9
ToppCelldroplet-Marrow-nan-21m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OBSCN ITGAX RHOU DOCK5 SLC27A4 PLD4 CSF1R IL17RD

5.89e-061712518355a27ea88410a84210f7e4298c7c4f90cf2f8a9
ToppCellnormal_Pleural_Fluid-Myeloid_cells-CD1c+_DCs|normal_Pleural_Fluid / Location, Cell class and cell subclass

RNF144B ITGAX DOCK5 SMPD3 KCNK17 PLD4 CASS4 CCNG2

6.15e-061722518200b2e63313b110b8ca59ee5b72c02cc8ed907cd
ToppCellmetastatic_Brain-B_lymphocytes-GrB-secreting_B_cells|B_lymphocytes / Location, Cell class and cell subclass

PALD1 CDH23 FMN1 SMPD3 KCNK17 PLD4 ZFYVE28 UHRF1

7.59e-06177251843e1d0d3cf8f0c02e67d91f8dd1761df23d59e07
ToppCellmoderate-Myeloid-pDC|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

PALD1 GAS6 MDN1 SMPD3 KCNK17 PLD4 FZD3 PCDH9

8.58e-0618025181d8df7df03a71f49d6683554d3c948ce90dda42e
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NUF2 DOCK5 PRRG4 USP35 PLXNA1 HEATR6 ARHGAP18 FIGNL1

8.94e-0618125183fe648db1cb8326066d8bde3ca1287c5c9af19bd
ToppCelldroplet-Fat-SCAT-30m-Epithelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BRCA2 YDJC PLXNB1 MUC5B TRIM45 CELSR2 OSBPL3 LTF

1.13e-0518725185fada3c5a58c1890029ccbfff2608b33f8cd2df7
ToppCelldroplet-Fat-SCAT-30m-Epithelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BRCA2 YDJC PLXNB1 MUC5B TRIM45 CELSR2 OSBPL3 LTF

1.13e-051872518766e808138fc2cd623c2e6d57fcb5c7378da0e03
ToppCelldroplet-Fat-SCAT-30m-Epithelial-epithelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BRCA2 YDJC PLXNB1 MUC5B TRIM45 CELSR2 OSBPL3 LTF

1.13e-051872518f49d06600060deeb2fc1b1da5b93496535f20104
ToppCellpdx-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

RGPD1 FMN1 CACNA1I ABCC1 RTTN CD44 IL17RD EPHB1

1.13e-0518725187e376831a11ee72ed87abcdac631ca46ae29c250
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 ITGAX GBP5 PIK3CD FMN1 ST8SIA4 PLD4 CSF1R

1.18e-0518825180d7296ad26e97ad91c6927a6cfe4e6e70a74c5a6
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ITGAX DOCK5 GLUL PLXNB1 CSF1R TLR4 LRP2 KIAA1755

1.22e-05189251842ab4cc5fbf8580841f31889446fe4499df1a464
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 ITGAX GBP5 PIK3CD FMN1 ST8SIA4 PLD4 CSF1R

1.27e-0519025187c402aa47f1bd7decacc366c1ed1a37e39b95c73
ToppCellCOVID-19_Mild-PLT_1|World / Disease Group and Platelet Clusters

ARMC3 RHOBTB1 GLUL VIL1 ARMC7 ING5 ARHGAP18 FRMD3

1.37e-051922518c86cb4b2df5102af904c362f3cbd24fe4462ba6c
ToppCellVE-pDC-|VE / Condition, Cell_class and T cell subcluster

RNF144B PALD1 GAS6 CDH23 SMPD3 KCNK17 PLD4 EPHB1

1.42e-051932518583724de588fcde3aeda056138c522dc0225a387
ToppCellVE-pDC|VE / Condition, Cell_class and T cell subcluster

RNF144B PALD1 GAS6 CDH23 SMPD3 KCNK17 PLD4 EPHB1

1.42e-051932518bb759dc9ef0ec41d655002f59021d62d62d44289
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HCN2 RHOU ADD3 DOCK5 AK5 SIK3 DNM3 LRP2

1.48e-051942518cb0422e7607dbd77204428b7e2c70dfe14a6ca11
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D231|Adult / Lineage, Cell type, age group and donor

CDH23 ITGAX FMN1 GLUL CCDC170 CASS4 CSF1R ARHGAP18

1.48e-051942518800d3d7a9e864d2d6a100a4e4af22f45d5790a8d
ToppCellCOVID-19-Myeloid-Monocyte-derived_macrophages|COVID-19 / group, cell type (main and fine annotations)

RNF144B ITGAX FMN1 GLUL ST8SIA4 CSF1R TLR4 ARHGAP18

1.53e-051952518c172c5599379c29123340621a36bfb1fc90c2115
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|lung / Disease (COVID-19 only), tissue and cell type

RNF144B ITGAX GBP5 FMN1 GLUL ST8SIA4 CSF1R ARHGAP18

1.53e-051952518148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RNF144B ITGAX PLEKHG5 FMN1 GLUL TRPV2 CSF1R ARHGAP18

1.53e-051952518247803cf58c6d9c561a52aa34e581188ddad197e
ToppCelldistal-Hematologic-Myeloid_Dendritic_Type_2-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PALD1 BTBD1 GRAMD4 DOCK5 FMN1 ST8SIA4 PLD4 CSF1R

1.53e-0519525187606b8b40e704bb5447ac57ccf8698794e9c7890
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-F_2|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ADD3 EDARADD USP47 RGPD2 WDR36 CD44 FRMPD3 ZC3HAV1

1.59e-051962518ea8eceacc5d5e1a22b77c31e7c45985dc7bb15de
ToppCelldroplet-Mammary_Gland-nan-3m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP6V1B1 SPINT1 GAS6 RHOU PRRG4 ARHGEF5 CELSR2 LTF

1.59e-05196251822fcfb713f402ebbd43b2822f0fd919cdbfba6e4
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GABRB1 ANKRD18B KCNC1 KCNK17 USP6 CELSR3 CELSR2 OGDHL

1.59e-0519625184bdc304c0c9d8bebe1a6a8a27e44acd1e8113725
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|COVID-19 / Disease (COVID-19 only), tissue and cell type

RNF144B ITGAX GBP5 FMN1 GLUL ST8SIA4 CSF1R ARHGAP18

1.59e-0519625187026c1fc33425e5476063d17c79e4b79356a9e01
ToppCellproximal-Epithelial-Neuroendocrine|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GABRB1 HCN2 DIO2 VIL1 SPHKAP OGDHL ESPL1 PCK1

1.71e-0519825185dea6078488d584513c0bdbf5bba54877310b54a
ToppCellproximal-Epithelial-Neuroendocrine-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GABRB1 HCN2 DIO2 VIL1 SPHKAP OGDHL ESPL1 PCK1

1.71e-05198251800ccf3020667cf2130bc354b441b65c0b1b0e862
ToppCellCOVID-19-kidney-Macrophages|kidney / Disease (COVID-19 only), tissue and cell type

ITGAX GBP5 FMN1 GLUL ST8SIA4 CCDC170 CSF1R CD44

1.71e-051982518161324541fe5da5cbb58142ea94fefd39b7dfb04
ToppCellproximal-3-Epithelial-Neuroendocrine|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GABRB1 HCN2 DIO2 VIL1 SPHKAP OGDHL ESPL1 PCK1

1.71e-051982518a6bc043faf68468d46bac441cf7447c236c7bae4
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HCN2 RHOU FGF1 PLXNB1 CELSR2 DNM3 LRP2 PCDH9

1.78e-0519925185d2e85e40b6b52b1809e680b952913d77215b3d0
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HCN2 RHOU FGF1 PLXNB1 CELSR2 DNM3 LRP2 PCDH9

1.78e-0519925186fb5f931e6217142de38c1fffc011e63bda4772b
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

WWC2 PLXNA1 PLXNB1 PAPSS2 CELSR1 DOK4 OSBPL3 ARHGEF1

1.78e-051992518d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HCN2 RHOU FGF1 PLXNB1 CELSR2 DNM3 LRP2 PCDH9

1.78e-0519925189dd4b17fb8c70ab9e126b23b72600463f3db832d
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HCN2 RHOU FGF1 PLXNB1 CELSR2 DNM3 LRP2 PCDH9

1.78e-0519925181bb5797e8e0552bf9b44bf4c958d1aa6dbe6c756
ToppCellControl_saline-Endothelial-Endothelial-Gen_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

PLEKHG5 ADD3 STXBP1 AFDN PML BAZ2B ARHGEF12 ARHGAP18

1.84e-0520025183b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

WWC2 PLXNB1 PAPSS2 CELSR1 DOK4 OSBPL3 ARHGEF1 OGDHL

1.84e-0520025188683445ad5b70748c4a1f12eb77d47623085147e
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HCN2 RHOU DOCK5 AK5 FGF1 DNM3 LRP2 PCDH9

1.84e-052002518159377d904394d91e09913131e9a93e08189955a
ToppCellcontrol|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SPINT1 PLEKHH3 AFDN PRRG4 PLXNB1 ARHGEF12 CELSR1 ATP2A2

1.84e-05200251897f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HCN2 RHOU DOCK5 AK5 FGF1 DNM3 LRP2 PCDH9

1.84e-0520025183ce8a2db8c25e1169a0a544f644a63104749c5ee
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Gen_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ATRX PLEKHG5 ADD3 STXBP1 AFDN BAZ2B ARHGEF12 ARHGAP18

1.84e-052002518a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HCN2 RHOU DOCK5 AK5 FGF1 DNM3 LRP2 PCDH9

1.84e-0520025180bfd41c12887479ceb62c3db0a3c3ba5007eb62b
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HCN2 RHOU DOCK5 AK5 FGF1 DNM3 LRP2 PCDH9

1.84e-052002518d30316836494f33ca46d4e415fd2ed179e9cb5ee
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK5 ADAMTS9 FGF1 NPHS1 TRIM58 FRMPD3 FRMD3

2.85e-0515525175a872ca70ae8c30b57f45a6772d7bf565e0c2663
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK5 ADAMTS9 FGF1 NPHS1 TRIM58 FRMPD3 FRMD3

2.85e-051552517e7f49e2fdaf184fa6b4e685518004e7deff1316d
ToppCellPND14-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RNF144B ITGAX TRPV2 PLD4 CCDC170 UHRF1 FIGNL1

2.97e-0515625178349604bd801e20d33770f7d8243598c3756302b
ToppCellPBMC-Control-cDC_1|Control / Compartment, Disease Groups and Clusters

IFIT5 PML ZBTB47 ZNF23 HELZ2 PNMA6A ZC3HAV1

2.97e-0515625179b6c5bcac516a62bcc1f5be32ffa8c92735ef0bc
ToppCellControl-Epithelial_airway|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARMC3 SPINT1 KRT78 LRRC46 CELSR1 OSBPL3 DNAH11

3.22e-05158251735aee1c3b92169e73569331022833cb44ab7e7e8
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLXNA1 ZFYVE28 TRMT44 UHRF1 KIAA1755 GASK1A DNAH11

3.36e-0515925177ed659163f45e0c4df4782997c0786900c8186c8
ToppCellURO-Other-RBC|URO / Disease, Lineage and Cell Type

GAS6 BCKDHB SMPD3 KCNK17 PLD4 FZD3 IL17RD

3.49e-051602517558f3b0719e2461a69e1b93b08e21675e8d07a5a
ToppCellCOVID_non-vent-Lymphocytic-Dendritic-pDC|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

PALD1 GAS6 SMPD3 KCNK17 PLD4 RNASE10 EPHB1

3.49e-05160251761f4cb4eb4313d8318aadbb99595a6cb7fd919f7
ToppCellURO-Other|URO / Disease, Lineage and Cell Type

GAS6 BCKDHB SMPD3 KCNK17 PLD4 FZD3 IL17RD

3.49e-051602517b0923e6bacfaba8ca40aa5706bf270eea0938b0a
ToppCellCOVID_non-vent-Lymphocytic-Dendritic|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

PALD1 GAS6 SMPD3 KCNK17 PLD4 RNASE10 EPHB1

3.49e-05160251734b4f710cfcb6ec370b8b074f3cbfe272f392cec
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FMN1 CARD6 HERC2 BRWD1 ANKFY1 CUBN ARHGEF1

3.64e-0516125175fba13f0aa5002f7eefe219e2c6a07e163f1a50d
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Myeloid-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GDF9 TMEM117 PLD4 TPCN2 ZBTB47 CSF1R ESPL1

3.78e-051622517b502d6af6868425b5c919740e011330c0d3cf3b8
ToppCellBac-SEP-Myeloid-tDC|Bac-SEP / Disease, Lineage and Cell Type

GAS6 AHDC1 RHOU NAGS PLD4 MSLN EPHB1

4.25e-0516525178728f927502e56f2768b4224e9111939d3d7815a
ToppCellLPS-IL1RA-Epithelial_airway-Club_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SPINT1 KRT78 MUC5B CELSR1 OSBPL3 MSLN DNAH11

4.25e-0516525171a114eacaab598f755a173a3fed842ba91f689dd
ToppCellLPS-IL1RA-Epithelial_airway-Club_cells-Airway|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SPINT1 KRT78 MUC5B CELSR1 OSBPL3 MSLN DNAH11

4.25e-0516525179cfd3c1d2c6d714fde83b90465f1f9741b0e50ce
ToppCellCerebellum-Macroglia-ASTROCYTE-Gja1-Gfap+_astrocytes_(Gfap)--|Cerebellum / BrainAtlas - Mouse McCarroll V32

NUF2 ADAMTS9 DIO2 PAPSS2 CELSR1 TMEM82

4.36e-051132516fed408864201218295bac0cc6647953fda8d688e
ToppCellCerebellum-Macroglia-ASTROCYTE-Gja1-Gfap+_astrocytes_(Gfap)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

NUF2 ADAMTS9 DIO2 PAPSS2 CELSR1 TMEM82

4.36e-051132516c0b8d7a2e3722029e850051bdff77f31f34a8cca
ToppCellCerebellum-Macroglia-ASTROCYTE-Gja1-Gfap+_astrocytes_(Gfap)|Cerebellum / BrainAtlas - Mouse McCarroll V32

NUF2 ADAMTS9 DIO2 PAPSS2 CELSR1 TMEM82

4.36e-0511325167e24c0f6a80e10a2a41325d48a87628bd330a1e2
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SPTBN2 EDARADD TMEM117 PAPSS2 LRRC9 ARHGAP18 LONRF2

4.42e-0516625176fe8db8d45177a78605681f22e04fa8d0594f2df
ToppCell10x5'-Liver-Myeloid_Dendritic-pDC|Liver / Manually curated celltypes from each tissue

GAS6 SMPD3 KCNK17 PLD4 USP6 PCDH9 EPHB1

4.42e-05166251724dfa9f3e0842f9ab8350bf6a52ae0d10f2a0c44
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-cDC2|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNF144B PALD1 HCN2 ITGAX PLD4 CSF1R IGHMBP2

4.59e-0516725171bd0aa7a3c8649f342bb856cf861c4c5984ad889
ToppCellfacs-Marrow-KLS-3m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP6V1B1 TTC21A BCOR AXIN2 CDC42EP5 ZBTB47 SHROOM1

4.59e-0516725172812353ff66e76f10bd327ceb0e6b009502a5258
ToppCellfacs-Marrow-KLS-3m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP6V1B1 TTC21A BCOR AXIN2 CDC42EP5 ZBTB47 SHROOM1

4.59e-051672517d15168f46c1599d9fc68a05a7b822c4b439f2987
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-mesothelial_cell-mesothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SPTBN2 SMPD3 TMEM117 ZNF23 MCTP2 MSLN FRMD3

4.59e-0516725171adb566f98af0109c8cc6e36033b89651e2c75e7
ToppCellmild_COVID-19_(asymptomatic)-pDC|World / disease group, cell group and cell class (v2)

PALD1 GAS6 AHDC1 KCNK17 PLD4 GASK1A EPHB1

4.59e-051672517bf08f17965a4dd03f371b4ed0ab0d5e62ed61307
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-mesothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SPTBN2 SMPD3 TMEM117 ZNF23 MCTP2 MSLN FRMD3

4.59e-051672517743df5908c1ceb43b34b240d9f9649f30f4142fa
ToppCell367C-Lymphocytic-ILC-ILC-1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

NDOR1 ITGAX PIK3R1 NPHS1 FASTKD1 LONRF2 DCUN1D3

4.77e-05168251780233a13135fd159f5764336a1fe67fba237776b
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AXIN2 FGF1 NPHS1 AMHR2 SPHKAP LRP2 MSLN

4.95e-0516925170cece9b2bb1f58e465c20ec8735a4fc3c1021f03
ToppCell3'_v3-Lung-Myeloid_Mac-Intestinal_macrophages|Lung / Manually curated celltypes from each tissue

PALD1 GAS6 RHOBTB1 FMN1 PCDHGB7 CSF1R PNMA6A

4.95e-051692517241644823e6f949aaf4c671d4579721d7ef6b0e5
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AXIN2 FGF1 NPHS1 AMHR2 SPHKAP LRP2 MSLN

4.95e-0516925176937c46b119d4ce382fc8c2fa5925ede5ae89c81
ToppCellBronchial_Brush-Immune-B_cells|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

ARMC3 PLEKHH3 ADD3 NUP160 TRIM58 FZD3 AP4B1

5.14e-05170251753e9372cb06a2dc5c8ecb3f9af42f3c23da96431
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-8|TCGA-Liver / Sample_Type by Project: Shred V9

TDRD15 SPTBN2 GAS6 GRAMD4 PAPSS2 OGDHL UPP2

5.33e-051712517c4a919fe3d56ae6df2fcab6686abacc10befc053
ToppCell368C-Myeloid-Dendritic-pDC|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

PFAS SMPD3 KCNK17 PLD4 DUS4L RICTOR EPHB1

5.33e-051712517714a0b0d0c9886fef64170cf53eb64f0d8a47280
ToppCellmetastatic_Lymph_Node-Myeloid_cells-pDCs|metastatic_Lymph_Node / Location, Cell class and cell subclass

PALD1 GAS6 SMPD3 KCNK17 PLD4 LONRF2 EPHB1

5.33e-0517125171f8e66073088fc1969782e443bf00f8c1877ea91
ToppCelldroplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SPINT1 PFAS ITGAX ALMS1 LRRC46 UHRF1 PCK1

5.53e-051722517b043d4f81dced7fb3326043f68474123be47cc5d
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_12|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AADACL4 SPINT1 GAS6 PLD4 CSF1R UHRF1 MSLN

5.74e-0517325179c7386bf0a899882c733f0b4921a96afde032a7d
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_12|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

AADACL4 SPINT1 GAS6 PLD4 CSF1R UHRF1 MSLN

5.74e-051732517a55f310c533432e9e26e400026a5b47245152976
ToppCellCTRL-Lymphoid-pDC|Lymphoid / Disease state, Lineage and Cell class

PALD1 GAS6 PFAS BRCA2 DIO2 SMPD3 EPHB1

5.95e-051742517ff4315e9fad198cc323fc987deb8652da137cf98
ToppCellIPF-Myeloid-pDC|World / Disease state, Lineage and Cell class

PALD1 GAS6 PFAS SMPD3 KCNK17 PLD4 EPHB1

6.17e-051752517a06785a4ded01adfd29ca4c20f7759eccbe274cb
ToppCellmild-Myeloid-pDC|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PALD1 GAS6 SMPD3 KCNK17 PLD4 FZD3 C17orf113

6.39e-05176251759a9c262c252b7d220a025837922d98e9d6b0a24
ToppCellCOVID-19-kidney-CD-IC-A|COVID-19 / Disease (COVID-19 only), tissue and cell type

SPTBN2 EDARADD TMEM117 ARMC7 OGDHL ARHGAP18 LONRF2

6.39e-05176251745028197364c64e93e3ffe86aff773d47a477d49
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Plasmacytoid_Dendritic_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 PIK3CD SMPD3 KCNK17 PLD4 ZFYVE26 EPHB1

6.39e-0517625178488997e0f02e874f53fae1690da63e0dd1d0780
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRRC39 NUF2 NUP160 KLHL25 TLR4 CD44 ZFYVE26

6.62e-0517725171d5a071157c755f3a27a5c3143015da04ee0b0dc
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ERC1 SPTBN2 COL22A1 EDARADD TMEM117 LRRC9 ARHGAP18

6.62e-051772517f35b04c3557ebbdeba37dec54c8f45880eafb422
ToppCellLA-17._Lymphocyte|World / Chamber and Cluster_Paper

TDRD15 GBP5 PIK3CD CD44 ARHGAP18 MCTP2 ZC3HAV1

6.86e-05178251734ec499d03cc198cfefa19a724d4c81974052f65
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NDOR1 NUF2 TPCN2 LRRC9 KANSL1 EXOC1

7.00e-051232516a45d6907c041ad3f3218cd46dccfc25d4bd961cb
Drugradicicol, diheterospora chlamydosporia; Down 200; 0.1uM; HL60; HT_HG-U133A

PFAS BCKDHB AHDC1 RHOBTB1 PIK3R1 PML ANKFY1 TRIM58 DUS4L PAPSS2 OSBPL3 ATP2A2

1.63e-06194249126178_DN
DrugSe-methylselenocysteine

ITGAX PER2 PIK3CD PIK3R1 ABCC1 PAPSS2 PCK1

9.45e-06682497CID000114835
DrugMetanephrine hydrochloride DL [881-95-8]; Down 200; 17.2uM; PC3; HT_HG-U133A

IRF2BP1 ZZEF1 CACNA1I VGLL1 PLXNB1 CASS4 BTBD2 ARNT CELSR2 PDE4DIP DNM3

9.69e-06193249116734_DN
DrugDehydroisoandosterone 3-acetate [853-23-6]; Up 200; 12.2uM; PC3; HT_HG-U133A

NDOR1 PRDM2 PER2 AFDN KLHL18 PML ARHGEF12 SCYL2 ARNT PDE4DIP CD44

1.02e-05194249116673_UP
DiseaseNEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE

NUP205 NUP160 NPHS1 ANKFY1 NUP93

3.96e-06302385C1868672
Diseasetotal lipids in small VLDL

ANKRD31 TDRD15 GAS6 SIK3 INTS10 CELSR2

1.71e-05672386EFO_0022148
DiseaseAdenoid Cystic Carcinoma

ATRX GAS6 BCOR KANSL1 UHRF1 IL17RD ESPL1

1.72e-051002387C0010606
DiseaseActivated PI3K-delta syndrome

PIK3CD PIK3R1

6.48e-0522382cv:CN295305
Diseaselung small cell carcinoma (is_implicated_in)

ATRX AXIN2 PIK3R1 RICTOR

7.26e-05282384DOID:5409 (is_implicated_in)
Diseaseovarian neoplasm

BRCA2 PIK3R1 FGF1 LRRC46 KANSL1 TLR4 MSLN

1.12e-041342387C0919267
Diseasephospholipids in VLDL measurement

TDRD15 GAS6 SIK3 INTS10 CELSR2

1.15e-04592385EFO_0022301
Diseasetotal lipids in VLDL measurement

TDRD15 GAS6 SIK3 INTS10 CELSR2

1.25e-04602385EFO_0022314
DiseaseMalignant neoplasm of ovary

BRCA2 PIK3R1 FGF1 LRRC46 KANSL1 TLR4 MSLN

1.29e-041372387C1140680
Diseasecholesterol in large VLDL measurement

TDRD15 GAS6 SIK3 INTS10 CELSR2

1.82e-04652385EFO_0021902
DiseaseACTIVATED PI3K-DELTA SYNDROME

PIK3CD PIK3R1

1.93e-0432382C3714976
Diseasebreast ductal carcinoma (is_implicated_in)

RICTOR CD44

1.93e-0432382DOID:3007 (is_implicated_in)
Diseasefree cholesterol in large VLDL measurement

ANKRD31 TDRD15 SIK3 INTS10 CELSR2

2.26e-04682385EFO_0022265
Diseaselung small cell carcinoma (is_marker_for)

ATRX RICTOR CSF1R

2.68e-04162383DOID:5409 (is_marker_for)
Diseaseresponse to acetylsalicylate

KLHL18 SCAP EPHB1

2.68e-04162383GO_1903492
Diseasefree cholesterol measurement

ANKRD31 TDRD15 IRF2BP1 GAS6 NUP160 CELSR2

3.18e-041132386EFO_0008591
DiseaseVitiligo

NFE2L2 PIK3R1 CD44

3.24e-04172383C0042900
Diseaseomega-3 polyunsaturated fatty acid measurement

TDRD15 GAS6 BRWD1 KANSL1 CELSR2 IGHMBP2

4.01e-041182386EFO_0010119
Diseaselow density lipoprotein cholesterol measurement, phospholipid measurement

TDRD15 GAS6 BRCA2 BRWD1 CELSR2 DNAH11

4.39e-041202386EFO_0004611, EFO_0004639
DiseaseMalignant neoplasm of kidney

BCOR BRCA2 DNM3 FIGNL1

4.74e-04452384C0740457
DiseaseAcute Promyelocytic Leukemia

BCOR ITGAX PML CD44

5.16e-04462384C0023487
Diseasevery low density lipoprotein cholesterol measurement, phospholipid measurement

TDRD15 GAS6 PIK3R1 BRWD1 SIK3 INTS10 CELSR2 DNAH11

5.74e-042292388EFO_0004639, EFO_0008317
Diseasecortical surface area measurement

PALD1 RGPD1 LRRC69 COL22A1 ADAMTS9 PIK3CD PIK3R1 YDJC USP35 ATXN10 AMHR2 FZD3 BAZ2B ARHGEF12 MED13L CELSR1 KANSL1 UHRF1 KIAA1755 IL17RD MCTP2 DNAH11 EPHB1

5.98e-04134523823EFO_0010736
DiseaseMalignant Neoplasms

ERCC1 PIK3R1 CSF1R LTF DCUN1D3 MSLN

6.18e-041282386C0006826
Diseaseesterified cholesterol measurement

ANKRD31 TDRD15 IRF2BP1 NUP160 SIK3 CELSR2

6.18e-041282386EFO_0008589
Diseaselung adenocarcinoma (is_marker_for)

ATRX NUF2 PIK3R1 CSF1R CD44

6.35e-04852385DOID:3910 (is_marker_for)
Diseasewhole-brain volume

CUBN DNAH11

6.38e-0452382EFO_0005089
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

GABRB1 GABRB3 PLXNB1 GRIN2D

6.58e-04492384DOID:0060037 (implicated_via_orthology)
Diseasecholine measurement

TDRD15 YDJC SIK3 KANSL1 CELSR2 NUP93

6.71e-041302386EFO_0010116
DiseaseBronchiectasis

PIK3CD PIK3R1 DNAH11

7.12e-04222383C0006267
Diseasetotal cholesterol measurement, diastolic blood pressure, triglyceride measurement, systolic blood pressure, hematocrit, ventricular rate measurement, glucose measurement, body mass index, high density lipoprotein cholesterol measurement

ANKRD31 TDRD15 SIK3 CELSR2

7.66e-04512384EFO_0004340, EFO_0004348, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928
Diseasecholesterol to total lipids in small VLDL percentage

ANKRD31 TDRD15 SIK3 CELSR2

7.66e-04512384EFO_0022242
DiseaseCarcinoma of lung

ERCC1 BRCA2 RICTOR

8.14e-04232383C0684249
Diseasetotal lipids in medium VLDL

TDRD15 GAS6 SIK3 CELSR2

9.51e-04542384EFO_0022153
Diseasetriglycerides in medium VLDL measurement

TDRD15 SIK3 INTS10 CELSR2

1.02e-03552384EFO_0022155
Diseasecholesterol to total lipids in large HDL percentage

SIK3 INTS10 CELSR2 NUP93

1.02e-03552384EFO_0022234
DiseaseFanconi Anemia

ERCC1 BRCA2 RFWD3

1.05e-03252383C0015625
Diseaseapolipoprotein B measurement

ANKRD31 TDRD15 ERCC1 GAS6 NAGS BRCA2 KCNK17 UQCRHL BRWD1 AMHR2 SIK3 CELSR2 NUP93 DNAH11

1.06e-0366323814EFO_0004615
Diseasetriglycerides in LDL measurement

TDRD15 GAS6 SIK3 CELSR2

1.09e-03562384EFO_0022320
Diseasecholesterol to total lipids in large LDL percentage

TDRD15 SIK3 CELSR2 NUP93

1.09e-03562384EFO_0022235
Diseasefree cholesterol to total lipids in medium VLDL percentage

ANKRD31 TDRD15 SIK3 CELSR2

1.17e-03572384EFO_0022284
Diseasecholesteryl ester measurement

ANKRD31 TDRD15 GAS6 YDJC SIK3 INTS10 CELSR2 NUP93

1.21e-032572388EFO_0010351
Diseasetriglycerides in IDL measurement

TDRD15 GAS6 SIK3 CELSR2

1.24e-03582384EFO_0022149
Diseasetriglycerides to total lipids in small VLDL percentage

ANKRD31 TDRD15 SIK3 CELSR2

1.24e-03582384EFO_0022338
Diseaselow density lipoprotein cholesterol measurement, alcohol consumption measurement

TDRD15 GAS6 RAB3GAP1 CELSR2 DNAH11

1.26e-03992385EFO_0004611, EFO_0007878
Diseasevery low density lipoprotein cholesterol measurement

ANKRD31 TDRD15 GAS6 BRWD1 SIK3 INTS10 CELSR2 DNAH11

1.30e-032602388EFO_0008317
Diseasefish oil supplement exposure measurement, high density lipoprotein cholesterol measurement

SIK3 INTS10

1.32e-0372382EFO_0004612, EFO_0600007
Diseaselaurylcarnitine measurement

AK5 ABCC1

1.32e-0372382EFO_0021041
Diseaseinfertility (implicated_via_orthology)

BRCA2 CSF1R

1.32e-0372382DOID:5223 (implicated_via_orthology)
Diseaseendometrial adenocarcinoma (is_implicated_in)

AXIN2 PIK3R1

1.32e-0372382DOID:2870 (is_implicated_in)
Diseasecholesterol in medium HDL measurement

YDJC SIK3 INTS10 CELSR2

1.33e-03592384EFO_0021903
DiseaseAcute kidney injury

GAS6 NFE2L2 TLR4 CD44 LRP2

1.38e-031012385C2609414
DiseaseAcute Kidney Insufficiency

GAS6 NFE2L2 TLR4 CD44 LRP2

1.38e-031012385C1565662
DiseaseKidney Failure, Acute

GAS6 NFE2L2 TLR4 CD44 LRP2

1.38e-031012385C0022660
Diseaseobsolete_red blood cell distribution width

IRF2BP1 GAS6 RGPD1 CDH23 ITGAX PLEKHG5 DOCK5 PIK3R1 AFDN YDJC ATP11C USP47 ABCC1 TRIM58 BAZ2B RBL1 NVL TRMT1 SIK3 INTS10 KANSL1 HELZ2

1.42e-03134723822EFO_0005192
Diseaselow density lipoprotein cholesterol measurement, alcohol drinking

TDRD15 GAS6 RAB3GAP1 CELSR2 DNAH11

1.44e-031022385EFO_0004329, EFO_0004611
Diseaseglucose metabolism disease (implicated_via_orthology)

PIK3CD DIO2 TLR4

1.46e-03282383DOID:4194 (implicated_via_orthology)
Diseasefree cholesterol in very large VLDL measurement

ANKRD31 TDRD15 SIK3 INTS10

1.50e-03612384EFO_0022274
Diseasefree cholesterol in VLDL measurement

TDRD15 GAS6 SIK3 CELSR2

1.50e-03612384EFO_0022276
Diseasecancer (implicated_via_orthology)

CAND2 AXIN2 BRCA2 PIK3CD RBL1 CSF1R FRMD6 PROX2

1.58e-032682388DOID:162 (implicated_via_orthology)
Diseasetriglycerides in medium LDL measurement

TDRD15 GAS6 SIK3 CELSR2

1.60e-03622384EFO_0022322
Diseasecutaneous melanoma, hair color

ADD3 HERC2 TPCN2 MED13L

1.60e-03622384EFO_0000389, EFO_0003924
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

ALMS1 ADAMTS9 PIK3CD ATP2A2 PCK1

1.64e-031052385DOID:9352 (implicated_via_orthology)
Diseasebreast carcinoma

SPTBN2 ADD3 BRCA2 PIK3R1 ATXN10 KLHL18 CCDC170 TPCN2 ARHGEF5 ARHGEF12 SIK3 KHDC4 INTS10 KANSL1 DNM3 AP4B1 LRRD1 DNAH11

1.65e-03101923818EFO_0000305
Diseaseurate measurement, bone density

ATP6V1B1 ERC1 HCN2 DOCK5 RHOBTB1 GBP5 BAZ2B SCYL2 HEATR6 HELZ2 KIAA1755 DNAH11 EPHB1

1.67e-0361923813EFO_0003923, EFO_0004531
Diseasetriglycerides to total lipids in medium VLDL percentage

ANKRD31 TDRD15 SIK3 CELSR2

1.69e-03632384EFO_0022335
Diseasecholesterol to total lipids in medium VLDL percentage

ANKRD31 TDRD15 SIK3 CELSR2

1.69e-03632384EFO_0022239
Diseasefamilial hyperlipidemia

TDRD15 ERCC1 GAS6 INTS10 CELSR2

1.71e-031062385MONDO_0001336
Diseaseesterified cholesterol measurement, intermediate density lipoprotein measurement

TDRD15 CELSR2

1.76e-0382382EFO_0008589, EFO_0008595
DiseaseVentricular Dysfunction, Left

NFE2L2 TLR4 ATP2A2

1.79e-03302383C0242698
Diseasetriglycerides in small LDL measurement

TDRD15 GAS6 SIK3 CELSR2

1.90e-03652384EFO_0022323
Diseasecholesterol in very large VLDL measurement

TDRD15 SIK3 INTS10 CELSR2

1.90e-03652384EFO_0022230
Diseaselow density lipoprotein cholesterol measurement, physical activity

TDRD15 PFAS CELSR2 DNAH11

2.01e-03662384EFO_0003940, EFO_0004611
Diseasenon-alcoholic fatty liver disease, type 2 diabetes mellitus

BCKDHB RICTOR MON1B DNM3 VPS53

2.02e-031102385EFO_0003095, MONDO_0005148
Diseasetriglyceride measurement, intermediate density lipoprotein measurement

GAS6 BRCA2 BRWD1 INTS10 CELSR2

2.10e-031112385EFO_0004530, EFO_0008595
Diseasetotal lipids in large VLDL

TDRD15 SIK3 INTS10 CELSR2

2.13e-03672384EFO_0022175
Diseasesquamous cell carcinoma

BRCA2 HERC2 TPCN2 DNAH11

2.13e-03672384EFO_0000707
DiseaseMYELODYSPLASTIC SYNDROME

ATRX BRCA2 SMPD3 CSF1R

2.13e-03672384C3463824
DiseaseBenign Neoplasm

ERCC1 CSF1R LTF MSLN

2.24e-03682384C0086692
DiseaseNeoplasms

ERCC1 CSF1R LTF MSLN

2.24e-03682384C0027651
DiseaseOsteitis Deformans

NUP205 PML

2.25e-0392382C0029401
Diseaseglucose metabolism decline measurement, cingulate cortex measurement

CDH23 VPS53

2.25e-0392382EFO_0007738, EFO_0009392
Diseasevery low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

ANKRD31 TDRD15 IRF2BP1 INTS10 CELSR2 HELZ2 NUP93

2.25e-032222387EFO_0008317, EFO_0020943
DiseaseSchizophrenia

GABRB1 GABRB3 SPTBN2 TRRAP CHRM5 STXBP1 GLUL PML FZD3 GRIN2D TLR4 LRP2 ARHGAP18 ATP2A2 MCTP2 PCK1

2.31e-0388323816C0036341
Diseasetriglyceride measurement, low density lipoprotein cholesterol measurement

TDRD15 GAS6 BRCA2 BRWD1 INTS10 CELSR2

2.35e-031662386EFO_0004530, EFO_0004611
Diseaselow density lipoprotein cholesterol measurement, lipid measurement

TDRD15 GAS6 BRCA2 BRWD1 CELSR2

2.36e-031142385EFO_0004529, EFO_0004611
Diseaseintracranial volume measurement

CCNG2 KANSL1 ATP2A2

2.36e-03332383EFO_0004886
Diseasetotal cholesterol measurement, hematocrit, stroke, ventricular rate measurement, body mass index, atrial fibrillation, high density lipoprotein cholesterol measurement, coronary artery disease, diastolic blood pressure, triglyceride measurement, systolic blood pressure, heart failure, diabetes mellitus, glucose measurement, mortality, cancer

ANKRD31 TDRD15 SIK3 CELSR2

2.37e-03692384EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004340, EFO_0004348, EFO_0004352, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928, MONDO_0004992
Disease4-vinylphenol sulfate measurement

GABRB3 EPHB1

2.79e-03102382EFO_0021149
Diseaseotitis media (is_marker_for)

MUC5B TLR4

2.79e-03102382DOID:10754 (is_marker_for)
DiseaseFanconi anemia (is_implicated_in)

BRCA2 RFWD3

2.79e-03102382DOID:13636 (is_implicated_in)
DiseaseCOVID-19 symptoms measurement

MUC5B KANSL1 LTF

2.80e-03352383EFO_0600019
Diseaseendometrial cancer (is_implicated_in)

BRCA2 PIK3CD PIK3R1

3.04e-03362383DOID:1380 (is_implicated_in)
Diseasecholesteryl esters to total lipids in very large HDL percentage

TDRD15 SIK3 CELSR2

3.04e-03362383EFO_0022257
Diseasecutaneous melanoma

ADD3 FMN1 HERC2 TPCN2 MED13L

3.05e-031212385EFO_0000389
Diseasecreatinine measurement

ATP6V1B1 CAND2 OBSCN ALMS1 NFE2L2 PIK3R1 NPHS1 VIL1 TPCN2 ATP6V1G1 CUBN RFWD3 CELSR3 CELSR2 LRP2 KIAA1755 PCK1

3.11e-0399523817EFO_0004518
Diseasehepatocellular carcinoma (is_marker_for)

ERCC1 PFAS NUF2 AXIN2 PML RICTOR CSF1R TLR4

3.22e-033012388DOID:684 (is_marker_for)
Diseasecolorectal carcinoma (is_marker_for)

AXIN2 BRCA2 CSF1R

3.29e-03372383DOID:0080199 (is_marker_for)
Diseasepigmentation disease (is_implicated_in)

HERC2 TPCN2

3.40e-03112382DOID:10123 (is_implicated_in)
Diseaseheart disease (implicated_via_orthology)

PIK3CD KCNK17 ATP2A2

3.55e-03382383DOID:114 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
PQLSDCEAAFVNRDL

ACCSL

121

Q4AC99
EIILDDDECPLQIFR

AFDN

316

P55196
IVEFCHPEDQQLLRD

ARNT

396

P27540
DFRCALLASEVPQLA

BRAT1

536

Q6PJG6
ELEEEFCRLRPLLSQ

ARHGEF1

886

Q92888
ESFLETLLQNDVCLP

ANKRD30B

731

Q9BXX2
NRLQILTEVAADRPC

CASS4

66

Q9NQ75
LDQIVESCLLPELNV

AZIN1

361

O14977
ILQSPAFREDLECLI

ADD3

61

Q9UEY8
VELACRDPSQVENLA

ATXN10

61

Q9UBB4
ACVLLSQSRLFEEPE

BTBD6

241

Q96KE9
QDLLVRLLSAAVCDP

BAZ2B

1136

Q9UIF8
REELDLLECYNSPQV

ARHGEF5

1501

Q12774
FNLTENERPLAVCEN

GRAMD4

451

Q6IC98
ENRQICAFSDVLPVL

AAR2

151

Q9Y312
NRDLFCSPLLVIQDS

ALMS1

206

Q8TCU4
LPSCIFLEQRELFEQ

ALMS1

2876

Q8TCU4
FLLAARIVEEDCNIP

CCNG2

106

Q16589
ELPCVENLNSIELNR

ANKRD18B

956

A2A2Z9
SLLRDQDPIVVVNCL

AP4B1

166

Q9Y6B7
IQCLQETEFPQTRIL

DNAH11

346

Q96DT5
PNTLAQLEEACRRLA

AXIN2

691

Q9Y2T1
EVIAQLPEAFLVSCE

AADACL4

331

Q5VUY2
LPEAFLVSCENDILR

AADACL4

336

Q5VUY2
CLQEPSDLRAVLLIN

ARMC3

591

Q5W041
TQRVLPFDDNICLRE

CELSR1

1296

Q9NYQ6
AQRVLPFDDNICLRE

CELSR2

1221

Q9HCU4
LTCPEAQLLEAQALE

AHDC1

251

Q5TGY3
RCNFPNVEIVTIAEA

BCOR

1681

Q6W2J9
VIQVLDVNDCRPQFS

CDH23

2496

Q9H251
SCIAENLVPNLFLEL

CDAN1

311

Q8IWY9
NDLCVDPTEFRVLLL

DCUN1D3

116

Q8IWE4
CVELLLSRNADPNVA

ASZ1

131

Q8WWH4
ELQELPELCFSQVIR

AMHR2

196

Q16671
DPEARLTAECVQQRL

AMHR2

491

Q16671
PQQDFEALLAECLRN

CAPN14

26

A8MX76
FVQDAESNPLCRRLQ

ARHGEF12

911

Q9NZN5
EDVPNDRCSALLELQ

C17orf113

141

A0A1B0GUU1
LQPNLVDLCASVAEL

NUP93

201

Q8N1F7
PLRELGQVVECSLDF

MUC5B

2926

Q9HC84
PLRELGQVVECSLDF

MUC5B

3626

Q9HC84
RELSVQLQPTDALLC

RAVER1

121

Q8IY67
DLERFVSCLLEQPEV

RAB3GAP1

866

Q15042
EPCVAELTEENFQRL

ERC1

256

Q8IUD2
AVREFLENNAELCQP

PCK1

26

P35558
LVDPLTTVREQCEQL

UQCRHL

26

A0A096LP55
LVDPLTTVREQCEQL

UQCRH

26

P07919
LLQDLQTDQPVLDIC

RFWD3

736

Q6PCD5
LAQIPNFAERAQCII

FMN1

1131

Q68DA7
SRQECPRQEQDIVFL

ITGAX

141

P20702
LRELFEQAVSNAPCI

NVL

346

O15381
NAPCIIFIDEIDAIT

NVL

356

O15381
DCEFLVQRARELVPQ

INTS10

6

Q9NVR2
ACPQDLIQAEDRQLI

NUP205

1296

Q92621
RCELQLEAVVENPLN

PCDHGB6

101

Q9Y5F9
RCELQLEAVVENPLN

PCDHGB7

101

Q9Y5F8
CAPREEDFDQLLEAL

PALD1

631

Q9ULE6
QLASIPRELCFLENL

LRRC69

141

Q6ZNQ3
PRELCFLENLVELQL

LRRC69

146

Q6ZNQ3
RTVDLIPVDQFRNVC

LRRC9

1106

Q6ZRR7
TLERNLCISQDVEFP

ZFYVE28

281

Q9HCC9
LCISQDVEFPIRADV

ZFYVE28

286

Q9HCC9
RNVLAECRLDPADLQ

MON1B

291

Q7L1V2
LQEAEIACLVPVDQF

RNF144B

86

Q7Z419
LPIFRCLNSLERNIE

RAD9B

91

Q6WBX8
INEILLISDQEFLPC

ANKRD31

1841

Q8N7Z5
RAIDENNEPTACFLI

ANKFY1

731

Q9P2R3
QEECFLNLEAPISRV

BCKDHB

346

P21953
NVEFVPRQLGLTECR

EPHB1

376

P54762
DLSQLIIRNCPSFDI

FASTK

141

Q14296
NRQLLVCEASSPALE

NPHS1

211

O60500
IFVDAPLNICESRDV

PAPSS2

146

O95340
CQQPAVIFIDEIDSL

FIGNL1

491

Q6PIW4
RCAAAQQLLERFSLP

DIO2

191

Q92813
FPRELCTLENLQVLD

LRRD1

571

A4D1F6
FCNPSVLDRLNALLE

MDN1

2246

Q9NU22
EDQQCLVFRDVAPQA

HINT2

71

Q9BX68
RTRACDLLLQPDNLA

IL17RD

181

Q8NFM7
DPFCLLELGNDRLQT

MCTP2

531

Q6DN12
AQDDPILLSFIRCLQ

MED13L

51

Q71F56
VRIQICPFENDTEAL

IL17REL

191

Q6ZVW7
PRDVAQALSFEDQIC

AK5

221

Q9Y6K8
TPDLVVFLACANQRL

AK5

236

Q9Y6K8
LFNELRPAVCNDLSI

HERC2

1516

O95714
FVDDRPQVVNALCQA

KIAA1755

186

Q5JYT7
ELCSLNQEDFFQRVP

GABPA

221

Q06546
RCRALEEELENPLNV

CFAP58

696

Q5T655
GNQFQCDDLIIRPLE

MED7

46

O43513
PEFQLICTNLDELRE

KIAA2026

761

Q5HYC2
VNRDICDLPQELSNL

LRRC39

161

Q96DD0
RTLAEICLNTEIEPF

DSG4

841

Q86SJ6
RENCLILAVTPANTD

DNM3

166

Q9UQ16
EQLIAASREDLALCP

ERCC1

261

P07992
CLFQDVDERAVPLLG

PER2

341

O15055
DEPQRFAADLLQCVQ

PLXNA1

551

Q9UIW2
LCAFPLDEVDRLANR

PLXNB1

321

O43157
ELLQNFTCLDRPALD

KCNK17

61

Q96T54
AAARAPEQVQRLIFC

OGDHL

876

Q9ULD0
LPICRVNDFETADIL

NUF2

96

Q9BZD4
ENECFFELEVVILPN

PCDH9

106

Q9HC56
LLSIPELQCLNIEND

NFE2L2

191

Q16236
AVVPFVILQCQRDSE

FAM209B

66

Q5JX69
APEDVSALLVQACRL

HEATR6

71

Q6AI08
EVEEQCRQLGLPLAA

PDZD3

301

Q86UT5
EAPLLERLSQLDSCV

KANSL1

651

Q7Z3B3
QGLEPVFEACLDQLR

KRT78

156

Q8N1N4
DLPCIENAVLALAQR

GBP5

306

Q96PP8
RRYPLDEQNCTLEIE

GABRB1

166

P18505
TEAAAVALIQDCRLP

GDPGP1

351

Q6ZNW5
RRYPLDEQNCTLEIE

GABRB3

166

P28472
QDLDTCDPRQLDVLY

MSLN

471

Q13421
ELSLRPCVENEFVAL

KRT82

211

Q9NSB4
RQVENLLDLPCLQFL

LRRC46

101

Q96FV0
VLSNVNLPADLDLVC

NAGS

306

Q8N159
DLLNCLRDDQPFLIT

LRP2

1736

P98164
QQPEAALLRCDQALE

LONRF2

211

Q1L5Z9
QIFLEDFCSPRQVAE

ARMC7

161

Q9H6L4
SNLAELRQLLDCDTP

PIK3R1

156

P27986
VCLLPDSLARVNNLF

SMPD3

131

Q9NY59
ELLLQQFSSRCEAPD

GOLGA2

346

Q08379
LRPDCDTQVELQFQL

HELZ

581

P42694
ICELALQNPEVVALR

RICTOR

191

Q6R327
DCLTLIPAFSREQEQ

NDOR1

506

Q9UHB4
EPRLQGCTAELVLQD

OBSCN

3936

Q5VST9
RDSCQLVLVESIPQD

PLD4

91

Q96BZ4
EVPDCFLEIASLTLQ

PROX2

536

Q3B8N5
RQADFVQVLSCVLDP

COG6

466

Q9Y2V7
LQFEDRFDIEVTPNC

CUBN

2261

O60494
RALPRNSILVCAEEQ

GASK1A

81

Q9UFP1
LSFLCEIRQTPEFEQ

FRMD3

556

A2A2Y4
RSVCIFLPNDESLNI

FRMD6

16

Q96NE9
EFDELNPSAQRDACL

ATP2A2

656

P16615
EPLLDLVTACNSVFE

ATRX

271

P46100
LVVCQRSNGERFPDL

ADAMTS9

1406

Q9P2N4
VVFEDQDALLPCLLT

CSF1R

116

P07333
QERFNIICDLLELSP

ESPL1

601

Q14674
PENAEFLTALCELRL

IFIT5

466

Q13325
LCRPQFLSDRVQQDD

KLHL18

231

O94889
VRLALLPSDCLQEAV

KLHL25

236

Q9H0H3
DTCPLAQEEILEINR

KCNC1

486

P48547
EIRDIQTINPLDVLC

CARD6

366

Q9BX69
QSECREVLLPLLTDQ

DOCK5

871

Q9H7D0
EFANRCLSPERVLLQ

BRCA2

2641

P51587
PLSLAQIDLNITCRF

CD44

16

P16070
DDQELIIPCLALVRA

CCNDBP1

236

O95273
DLPFRIQSCAAQAVL

FRMPD3

846

Q5JV73
ECALAALLPAREATQ

GAS6

26

Q14393
QARLFDEPQLASLCL

BTBD1

186

Q9H0C5
FLNCITIALERPQIE

CACNA1I

1181

Q9P0X4
ISRIEAVLPQCDLNN

FASTKD1

436

Q53R41
PVECLRENIAFELPQ

IFNK

56

Q9P0W0
DCALVQTLPIEEREN

COL22A1

381

Q8NFW1
VNLIFQCEDSEPFRQ

BRWD1

1326

Q9NSI6
QARCRPNADLELNDV

CDC42EP5

131

Q6NZY7
LDSIENLPCELQRNF

ING5

11

Q8WYH8
DELCFLEQRPQSPTL

EDARADD

151

Q8WWZ3
FLLEDRVACNASIPA

FZD3

256

Q9NPG1
EVEINDVPLTCRNLL

KHDC4

106

Q7Z7F0
DCPLIVQFAANDARL

DUS4L

81

O95620
IFRCIEPELNNLIAL

EXOC1

586

Q9NV70
FLLPQNECELHDFRL

GDF9

346

O60383
FLTQLRDCLDPDERN

CCDC170

171

Q8IYT3
VCDNLLNVPDDILQL

DPEP3

296

Q9H4B8
RQIPRLNNLICDESD

ELP4

351

Q96EB1
RSLLDVLPFDDNVCL

CELSR3

1366

Q9NYQ7
RSLLDFCEAQQTLVP

HELZ2

2621

Q9BYK8
LFDEPQLASLCLENI

BTBD2

231

Q9BX70
LDRLVPLVEDFCNLD

CAND2

256

O75155
LIFERALVENCLVPD

SART3

331

Q15020
PARQILVLDNAAIVC

SCAP

1246

Q12770
ELNGPLREEIVNFNC

HCN2

521

Q9UL51
LCDLLASAADPQIRQ

IPO4

41

Q8TEX9
VQCEQTDRFNVFLLP

DOK4

131

Q8TEW6
IPTVCEELFRAIENQ

KIF28P

131

B7ZC32
EQLLALSACAPFNVR

IRF2BP1

231

Q8IU81
ELQNCELERIPHAIF

LRRC8D

641

Q7L1W4
CSGEEQNLFPLEINR

PRDM2

106

Q13029
EPLNTLQRLCEELEY

OSBPL3

551

Q9H4L5
NEPLNTLQRLCEELE

OSBPL7

501

Q9BZF2
QQVREICISRDFLPG

PIAS2

186

O75928
NAPESICILDLEVFL

RGPD1

466

P0DJD0
SLRENILFGCQLEEP

ABCC1

721

P33527
IRTCLLNETGDEPFQ

GLUL

356

P15104
LLEQCESFIPVLQDT

RTL3

301

Q8N8U3
LNRFLQVLPACTEDE

RTTN

1126

Q86VV8
VTLLDRLDCDQINLP

UPP2

276

O95045
VCLFLNLANDPTIER

ATP6V1B1

251

P15313
NAAIRDCDRAIEINP

ST13P4

161

Q8IZP2
LCSREVPLIQIETDQ

SPHKAP

1421

Q2M3C7
PVQEFNRDLTCAVIT

TRMT1

76

Q9NXH9
TCLEQLEPFSVVDIR

TRIM45

51

Q9H8W5
CAALPRDFIDQVVLQ

TRMT44

601

Q8IYL2
CRQLEAASLQAIPTE

SMYD4

451

Q8IYR2
LQTCRDLPALRDELF

PLEKHH3

291

Q7Z736
PIQCIQAIAENRADA

LTF

61

P02788
LSCILAQQPDRLRDE

TRADD

136

Q15628
LCAINPRFLLLESQA

TDRD15

846

B5MCY1
QLINIFESCVRNPVE

RBL1

411

P28749
FEECQRLLLDIPLQT

RGPD2

1156

P0DJD1
LCRLRQEEPQSLQAA

PML

356

P29590
SQTPNEECLFLERLE

FGF1

91

P05230
DADPNFDRLIAECQQ

SIK3

321

Q9Y2K2
VIRCNLAPVVEFAAD

ST8SIA4

166

Q92187
LEAAVRQACAPQELE

SHROOM1

686

Q2M3G4
ELCLNIIPTFANLID

SCYL2

466

Q6P3W7
DNPLCADVLFILQDQ

RHOBTB1

261

O94844
FTPLQLQELECIFQR

RHOXF2B

141

P0C7M4
LQELECIFQREQFPS

RHOXF2B

146

P0C7M4
NPILERLAEQIATLC

STXBP1

166

P61764
CTAAPTNRQIEILEL

NUP160

1166

Q12769
ALLAENPARTAQDCL

PNMA6A

211

P0CW24
RTVPLDECQIQFLSE

CHRM5

176

P08912
EVQADETFPCDLILL

ATP11C

151

Q8NB49
PVRLQLCDTAGQDEF

RHOU

96

Q7L0Q8
GQVVDCSRLFDNDLP

SMURF2

146

Q9HAU4
QVNAILPALSRCFEL

PRAMEF6

366

Q5VXH4
EVAAEFLNDRVPNCN

UBA3

126

Q8TBC4
CEVEAERLFSNIPEI

PLEKHG5

376

O94827
LPSFRAIQDDCQVIT

VPS51

216

Q9UID3
QEENLVITPRLFECS

VIL1

611

P09327
RVLDPLLCDFLDSQD

TBC1D17

471

Q9HA65
CPVRTSLDLELDLQA

WWC2

1061

Q6AWC2
RPFDLTLCELSQPDQ

RNASE10

171

Q5GAN6
VTRDQADPQCLFLRQ

SPTBN2

1131

O15020
ADPQCLFLRQRLEAL

SPTBN2

1136

O15020
PTGNCDLERFAQVLE

SLC27A4

556

Q6P1M0
CAPSNIAVDNLVERL

IGHMBP2

241

P38935
NCNLALVELQPDRGE

SPINT1

96

O43278
NTPCVLDLQRALVQD

STYXL2

111

Q5VZP5
FQLDRLQAEPRCVAE

PFAS

1016

O15067
LEAARQPLEREQCLA

USP35

26

Q9P2H5
FEFCDSLQQIVIPER

nan

66

Q6ZSR6
QVNAILPALSRCFEL

PRAMEF5

366

Q5TYX0
VNACILPLLQIDRDS

TRPV2

131

Q9Y5S1
CPTVQLEDIRNLQDL

TRPV2

281

Q9Y5S1
FLQIENAAEEPRVLC

USP47

31

Q96K76
NAAEEPRVLCIIQDT

USP47

36

Q96K76
LLQDFRDQNIPGCES

TTMP

191

Q5BVD1
LDNLLAFVCDIRPEI

ATP6V1G1

96

O75348
LPQVREELEAQLSCF

YDJC

106

A8MPS7
ELEDEQRRLCDVQPF

PIK3CD

81

O00329
ECIRLRPESALAQAQ

TOMM70

426

O94826
DLELFTPGNLERECN

PRRG4

56

Q9BZD6
SPDQGDDLENCILRF

TSTD2

6

Q5T7W7
RTLLDLCQIQDFPSQ

TMEM82

306

A0PJX8
QSILQRCLELDPASV

TTC21A

521

Q8NDW8
NVLRDACLVANILDP

VPS53

236

Q5VIR6
SIQLLVQDLDAACDP

VPS53

601

Q5VIR6
EQRLFQPDLCDVDLV

ZBTB47

6

Q9UFB7
LFCVPLTALLEQDQR

ARHGAP18

321

Q8N392
RALALNCFAPINDQE

UHRF1

506

Q96T88
NPREECVSAQTLLLQ

ZZEF1

781

O43149
LNDPSLVCIRSDFNE

TMEM117

461

Q9H0C3
LLQEIALSEPQLCEV

ZC3HAV1

26

Q7Z2W4
EELVEPFRCDSQLIQ

ZNF23

171

P17027
ALQELNRCPFRVVDE

SMC5

1006

Q8IY18
SFPELQVLDLSRCEI

TLR4

76

O00206
RENPDLACLQSIIFD

TTC4

56

O95801
LACLQSIIFDEERSP

TTC4

61

O95801
LLQQDRCLARPQESA

VGLL1

171

Q99990
QVARECERLLEQFPL

ZFYVE26

1351

Q68DK2
LRTLELCVDNLQPDF

TRRAP

846

Q9Y4A5
AQAEPINLDSCLRAF

USP6

1026

P35125
PAERDDFILGILNCV

TPCN2

461

Q8NHX9
ELADELQERCQRPAL

TRIM58

231

Q8NG06
RDSQRAPEAVLCLQL

WDR36

11

Q8NI36
VPIDDLCQFLIVATN

PP2D1

441

A8MPX8
SIPQLCNENRVLRED

PDE4DIP

1896

Q5VU43
LLPEEAQRCGTVLDQ

MZF1

211

P28698
AQIRLLFCAREEAEP

GRIN2D

241

O15399