Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	7.62e-13	37	73	8	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	9.63e-13	38	73	8	GO:0070001
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-6 ERAP2 ERVK-8 ERVK-19 ERVK-7 MME ERVK-21 ERVK-9 ERVK-10 HTRA4 ERVK-24 CTSG	4.79e-08	430	73	12	GO:0004175
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	5.32e-08	11	73	4	GO:0004523
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	1.60e-07	14	73	4	GO:0003964
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7 ERVK-10 PRORP	2.26e-07	37	73	5	GO:0016891
GeneOntologyMolecularFunction	peptidase activity	ERVK-6 USP42 ERAP2 ERVK-8 ERVK-19 ERVK-7 MME ERVK-21 ERVK-9 ERVK-10 HTRA4 ERVK-24 CTSG	6.27e-07	654	73	13	GO:0008233
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7 ERVK-10 PRORP	6.93e-07	46	73	5	GO:0016893
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-8 ERVK-7 ERVK-10	9.39e-07	21	73	4	GO:0035613
GeneOntologyMolecularFunction	zinc ion binding	ERVK-6 KDM5B DHX58 ERAP2 POLR2A ERVK-8 ERVK-19 PGLYRP3 ERVK-7 MME ERVK-21 ERVK-9 ERVK-10 ERVK-24	3.55e-06	891	73	14	GO:0008270
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 PRORP	1.04e-05	79	73	5	GO:0004521
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10	1.10e-05	38	73	4	GO:0034061
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-6 POLR2A ERVK-8 PARP9 ERVK-7 ERVK-10	1.97e-05	152	73	6	GO:0016779
GeneOntologyMolecularFunction	transition metal ion binding	ERVK-6 KDM5B DHX58 ERAP2 POLR2A ERVK-8 ERVK-19 PGLYRP3 ERVK-7 MME ERVK-21 ERVK-9 ERVK-10 ERVK-24 ALOX15	2.13e-05	1189	73	15	GO:0046914
GeneOntologyMolecularFunction	benzoate-CoA ligase activity	ACSM2A ACSM2B	3.95e-05	3	73	2	GO:0018858
GeneOntologyMolecularFunction	decanoate-CoA ligase activity	ACSM2A ACSM2B	7.87e-05	4	73	2	GO:0102391
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 PRORP	1.41e-04	136	73	5	GO:0004540
GeneOntologyMolecularFunction	endonuclease activity	ERVK-6 ERVK-8 ERVK-7 ERVK-10 PRORP	1.41e-04	136	73	5	GO:0004519
GeneOntologyMolecularFunction	transcription corepressor activity	KDM5B HIPK1 NR0B1 TLE7 PARP9 SUFU	1.91e-04	229	73	6	GO:0003714
GeneOntologyMolecularFunction	nuclease activity	ERVK-6 EXD3 ERVK-8 ERVK-7 ERVK-10 PRORP	2.00e-04	231	73	6	GO:0004518
GeneOntologyMolecularFunction	fatty-acyl-CoA synthase activity	ACSM2A ACSM2B	3.64e-04	8	73	2	GO:0004321
GeneOntologyMolecularFunction	mannosyl-oligosaccharide mannosidase activity	MAN2A1 EDEM1	5.82e-04	10	73	2	GO:0015924
GeneOntologyMolecularFunction	medium-chain fatty acid-CoA ligase activity	ACSM2A ACSM2B	7.10e-04	11	73	2	GO:0031956
GeneOntologyMolecularFunction	catalytic activity, acting on RNA	ERVK-6 DHX58 POLR2A ERVK-8 ERVK-7 ERVK-10 PRORP	8.20e-04	417	73	7	GO:0140098
GeneOntologyMolecularFunction	alpha-mannosidase activity	MAN2A1 EDEM1	1.34e-03	15	73	2	GO:0004559
GeneOntologyMolecularFunction	structural molecule activity	ERVK-6 KRT78 ERVK-8 LAMA3 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	1.44e-03	891	73	10	GO:0005198
GeneOntologyMolecularFunction	mannosidase activity	MAN2A1 EDEM1	1.53e-03	16	73	2	GO:0015923
GeneOntologyMolecularFunction	peptidoglycan binding	PGLYRP3 NOD2	2.17e-03	19	73	2	GO:0042834
GeneOntologyMolecularFunction	C-acyltransferase activity	ACSM2A ACSM2B	2.65e-03	21	73	2	GO:0016408
GeneOntologyMolecularFunction	fatty acid ligase activity	ACSM2A ACSM2B	4.05e-03	26	73	2	GO:0015645
GeneOntologyMolecularFunction	CoA-ligase activity	ACSM2A ACSM2B	4.36e-03	27	73	2	GO:0016405
GeneOntologyMolecularFunction	transcription coregulator activity	KDM5B HIPK1 NR0B1 TLE7 SUPT20HL2 PARP9 SUFU	4.42e-03	562	73	7	GO:0003712
GeneOntologyMolecularFunction	acid-thiol ligase activity	ACSM2A ACSM2B	5.72e-03	31	73	2	GO:0016878
GeneOntologyBiologicalProcess	viral process	ERVK-6 EIF2D MAN2A1 ERVK-8 ERVK-19 PARP9 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 FCN3	6.60e-08	464	72	12	GO:0016032
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-8 ERVK-7 ERVK-10	9.53e-08	13	72	4	GO:0015074
GeneOntologyBiologicalProcess	RNA-templated DNA biosynthetic process	HMBOX1 ERVK-6 ERVK-8 ERVK-7 ERVK-10	1.06e-05	83	72	5	GO:0006278
GeneOntologyBiologicalProcess	cell-cell fusion	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	1.19e-05	85	72	5	GO:0140253
GeneOntologyBiologicalProcess	syncytium formation by plasma membrane fusion	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	1.19e-05	85	72	5	GO:0000768
GeneOntologyBiologicalProcess	syncytium formation	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	1.49e-05	89	72	5	GO:0006949
GeneOntologyBiologicalProcess	DNA synthesis involved in DNA repair	ERVK-6 ERVK-8 ERVK-7 ERVK-10	2.36e-05	48	72	4	GO:0000731
Domain	HJURP_C	MEF2A MEF2C	7.57e-05	4	67	2	IPR022102
Domain	HJURP_C	MEF2A MEF2C	7.57e-05	4	67	2	PF12347
Domain	MADS_MEF2-like	MEF2A MEF2C	7.57e-05	4	67	2	IPR033896
Domain	MADS	MEF2A MEF2C	1.88e-04	6	67	2	SM00432
Domain	MADS_BOX_1	MEF2A MEF2C	1.88e-04	6	67	2	PS00350
Domain	SRF-TF	MEF2A MEF2C	1.88e-04	6	67	2	PF00319
Domain	MADS_BOX_2	MEF2A MEF2C	1.88e-04	6	67	2	PS50066
Domain	TF_MADSbox	MEF2A MEF2C	2.63e-04	7	67	2	IPR002100
Domain	LAM_G_DOMAIN	CELSR2 CSPG4 LAMA3	3.40e-04	38	67	3	PS50025
Domain	Laminin_G_2	CELSR2 CSPG4 LAMA3	3.96e-04	40	67	3	PF02210
Domain	LamG	CELSR2 CSPG4 LAMA3	5.26e-04	44	67	3	SM00282
Domain	Laminin_G	CELSR2 CSPG4 LAMA3	1.18e-03	58	67	3	IPR001791
Domain	AMP-bd_C	ACSM2A ACSM2B	1.67e-03	17	67	2	IPR025110
Domain	AMP-binding_C	ACSM2A ACSM2B	1.67e-03	17	67	2	PF13193
Domain	Growth_fac_rcpt_	CELSR2 INSRR LAMA3 HTRA4	2.39e-03	156	67	4	IPR009030
Domain	NACHT	NLRP5 NOD2	3.06e-03	23	67	2	PS50837
Domain	NACHT_NTPase	NLRP5 NOD2	3.06e-03	23	67	2	IPR007111
Domain	AMP-binding_CS	ACSM2A ACSM2B	3.90e-03	26	67	2	IPR020845
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-10 ERVK-24	2.22e-11	4	77	4	10469592
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	3.65e-11	12	77	5	14557543
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24	3.79e-11	94	77	8	21542922
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-19 ERVK-7 ERVK-21	1.11e-10	5	77	4	12629516
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-19 ERVK-10	4.17e-08	4	77	3	7983737
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-21 ERVK-9 ERVK-10 ERVK-24	6.64e-08	18	77	4	18664271
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-19 ERVK-9	2.08e-07	6	77	3	15063128
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-6 ERVK-19 ERVK-21	1.24e-06	10	77	3	12970426
Pubmed	The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population.	ACSM2A ACSM2B	4.84e-06	2	77	2	16521160
Pubmed	Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice.	MEF2A MEF2C	4.84e-06	2	77	2	16469744
Pubmed	Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension.	MEF2A MEF2C	4.84e-06	2	77	2	25336633
Pubmed	A function for AAMP in Nod2-mediated NF-kappaB activation.	AAMP NOD2	4.84e-06	2	77	2	19535145
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	4.84e-06	2	77	2	9060628
Pubmed	Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.	ERVK-6 ERVK-19	4.84e-06	2	77	2	9460924
Pubmed	Regulation of myocyte enhancer factor-2 transcription factors by neurotoxins.	MEF2A MEF2C	4.84e-06	2	77	2	21741404
Pubmed	Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines.	ACSM2A ACSM2B	4.84e-06	2	77	2	19634011
Pubmed	Peptidoglycan recognition protein 3 and Nod2 synergistically protect mice from dextran sodium sulfate-induced colitis.	PGLYRP3 NOD2	4.84e-06	2	77	2	25114103
Pubmed	Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B.	ACSM2A ACSM2B	4.84e-06	2	77	2	29948332
Pubmed	Overexpression of myocyte enhancer factor 2 and histone hyperacetylation in hepatocellular carcinoma.	MEF2A MEF2C	4.84e-06	2	77	2	17611778
Pubmed	The nuclear localization domain of the MEF2 family of transcription factors shows member-specific features and mediates the nuclear import of histone deacetylase 4.	MEF2A MEF2C	1.45e-05	3	77	2	11792813
Pubmed	Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.	POLR2A CSPG4	1.45e-05	3	77	2	31221773
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-19	1.45e-05	3	77	2	10516026
Pubmed	An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133.	MEF2A MEF2C	1.45e-05	3	77	2	18093911
Pubmed	MEF2 is a converging hub for histone deacetylase 4 and phosphatidylinositol 3-kinase/Akt-induced transformation.	MEF2A MEF2C	1.45e-05	3	77	2	24043307
Pubmed	Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain.	MEF2A MEF2C	1.45e-05	3	77	2	15834131
Pubmed	Comparison of EMA,CEA, CD10 and Bcl-2 Biomarkers by Immunohistochemistry in Squamous Cell Carcinoma and Basal Cell Carcinoma of the Skin.	CEACAM5 MME	1.45e-05	3	77	2	27039776
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-9	1.45e-05	3	77	2	9971820
Pubmed	In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival.	MEF2A MEF2C	1.45e-05	3	77	2	22496871
Pubmed	Inducible knockout of Mef2a, -c, and -d from nestin-expressing stem/progenitor cells and their progeny unexpectedly uncouples neurogenesis and dendritogenesis in vivo.	MEF2A MEF2C	1.45e-05	3	77	2	26286136
Pubmed	MEF2 transcription factors differentially contribute to retinal ganglion cell loss after optic nerve injury.	MEF2A MEF2C	1.45e-05	3	77	2	33315889
Pubmed	Experience-Dependent and Differential Regulation of Local and Long-Range Excitatory Neocortical Circuits by Postsynaptic Mef2c.	MEF2A MEF2C	1.45e-05	3	77	2	27989458
Pubmed	Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes.	MEF2A MEF2C	2.89e-05	4	77	2	15140898
Pubmed	Neurotoxin-induced selective ubiquitination and regulation of MEF2A isoform in neuronal stress response.	MEF2A MEF2C	2.89e-05	4	77	2	22764880
Pubmed	Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23.	MEF2A MEF2C	2.89e-05	4	77	2	8575763
Pubmed	Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors.	MEF2A MEF2C	2.89e-05	4	77	2	10330143
Pubmed	MEF2 transcription factors regulate distinct gene programs in mammalian skeletal muscle differentiation.	MEF2A MEF2C	2.89e-05	4	77	2	25416778
Pubmed	Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene.	MEF2A MEF2C	2.89e-05	4	77	2	10207130
Pubmed	Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins.	MEF2A MEF2C	2.89e-05	4	77	2	8548800
Pubmed	Spine growth in the anterior cingulate cortex is necessary for the consolidation of contextual fear memory.	MEF2A MEF2C	2.89e-05	4	77	2	21531906
Pubmed	Requirement of MEF2A, C, and D for skeletal muscle regeneration.	MEF2A MEF2C	2.89e-05	4	77	2	24591619
Pubmed	Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation.	MEF2A MEF2C	2.89e-05	4	77	2	7643214
Pubmed	Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells.	ACSM2A ACSM2B	2.89e-05	4	77	2	32830538
Pubmed	TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters.	MEF2A MEF2C	2.89e-05	4	77	2	12061776
Pubmed	Neuronal Myocyte-Specific Enhancer Factor 2D (MEF2D) Is Required for Normal Circadian and Sleep Behavior in Mice.	MEF2A MEF2C	2.89e-05	4	77	2	31420455
Pubmed	Early expression of the different isoforms of the myocyte enhancer factor-2 (MEF2) protein in myogenic as well as non-myogenic cell lineages during mouse embryogenesis.	MEF2A MEF2C	2.89e-05	4	77	2	8817457
Pubmed	Dermo-1, a multifunctional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation.	MEF2A MEF2C	2.89e-05	4	77	2	11809751
Pubmed	Comparative analysis of apoptosis and inflammation genes of mice and humans.	NFKBIE CUL7 NLRP5 NOD2	3.09e-05	80	77	4	12819136
Pubmed	Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis.	MEF2A MEF2C	4.82e-05	5	77	2	19093215
Pubmed	Calcineurin initiates skeletal muscle differentiation by activating MEF2 and MyoD.	MEF2A MEF2C	4.82e-05	5	77	2	12694204
Pubmed	Expression of MEF2 genes during human cardiac development.	MEF2A MEF2C	4.82e-05	5	77	2	10458488
Pubmed	Control of the SOST bone enhancer by PTH using MEF2 transcription factors.	MEF2A MEF2C	4.82e-05	5	77	2	17696759
Pubmed	Membrane hyperpolarization triggers myogenin and myocyte enhancer factor-2 expression during human myoblast differentiation.	MEF2A MEF2C	4.82e-05	5	77	2	15084602
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-7	4.82e-05	5	77	2	11401426
Pubmed	The MEF2B homologue differentially expressed in mouse embryonal carcinoma cells.	MEF2A MEF2C	4.82e-05	5	77	2	7646512
Pubmed	HDAC4 integrates PTH and sympathetic signaling in osteoblasts.	MEF2A MEF2C	4.82e-05	5	77	2	24934156
Pubmed	Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1.	MEF2A MEF2C	4.82e-05	5	77	2	9753748
Pubmed	Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors.	MEF2A MEF2C	4.82e-05	5	77	2	20833138
Pubmed	Absence of MEF2 binding to the A/T-rich element in the muscle creatine kinase (MCK) enhancer correlates with lack of early expression of the MCK gene in embryonic mammalian muscle.	MEF2A MEF2C	4.82e-05	5	77	2	8993831
Pubmed	Postsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity.	MEF2A MEF2C	4.82e-05	5	77	2	23511190
Pubmed	Regulatory role of MEF2D in serum induction of the c-jun promoter.	MEF2A MEF2C	4.82e-05	5	77	2	7760790
Pubmed	Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family.	MEF2A MEF2C	4.82e-05	5	77	2	8900141
Pubmed	Regulation of the MEF2 family of transcription factors by p38.	MEF2A MEF2C	4.82e-05	5	77	2	9858528
Pubmed	Cooperation between MEF2 and PPARgamma in human intestinal beta,beta-carotene 15,15'-monooxygenase gene expression.	MEF2A MEF2C	4.82e-05	5	77	2	16504037
Pubmed	MEF2 transcription factors are key regulators of sprouting angiogenesis.	MEF2A MEF2C	4.82e-05	5	77	2	27898394
Pubmed	Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases.	MEF2A MEF2C	7.22e-05	6	77	2	10737771
Pubmed	The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2.	MEF2A MEF2C	7.22e-05	6	77	2	22135324
Pubmed	Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation.	MEF2A MEF2C	7.22e-05	6	77	2	15173318
Pubmed	TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2.	MEF2A MEF2C	7.22e-05	6	77	2	20399744
Pubmed	The expression of MEF2 genes is implicated in CNS neuronal differentiation.	MEF2A MEF2C	7.22e-05	6	77	2	9013788
Pubmed	Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins.	MEF2A MEF2C	7.22e-05	6	77	2	11160896
Pubmed	Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly.	BMP5 LAMA3 TG	9.72e-05	40	77	3	27068110
Pubmed	Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2.	MEF2A MEF2C	1.01e-04	7	77	2	9418854
Pubmed	Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis.	MEF2A MEF2C	1.01e-04	7	77	2	8026334
Pubmed	Transcription enhancer factor 1 binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions.	MEF2A MEF2C	1.01e-04	7	77	2	12861002
Pubmed	Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation.	MEF2A MEF2C	1.01e-04	7	77	2	11081517
Pubmed	Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers.	MEF2A MEF2C	1.34e-04	8	77	2	17786239
Pubmed	MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters.	MEF2A MEF2C	1.34e-04	8	77	2	16043483
Pubmed	MEF2B Instructs Germinal Center Development and Acts as an Oncogene in B Cell Lymphomagenesis.	MEF2A MEF2C	1.34e-04	8	77	2	30205047
Pubmed	PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation.	PGLYRP3 NOD2	1.34e-04	8	77	2	19218085
Pubmed	Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes.	MEF2A MEF2C	1.72e-04	9	77	2	8530078
Pubmed	Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo.	MEF2A MEF2C	1.72e-04	9	77	2	9738004
Pubmed	Myocyte Enhancer Factor 2c Regulates Dendritic Complexity and Connectivity of Cerebellar Purkinje Cells.	MEF2A MEF2C	2.15e-04	10	77	2	30276662
Pubmed	Identification of Osr2 Transcriptional Target Genes in Palate Development.	BMP5 MEF2C	2.63e-04	11	77	2	28731788
Pubmed	Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C.	MEF2A MEF2C	2.63e-04	11	77	2	9162005
Pubmed	The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.	NAT16 NOD2	3.15e-04	12	77	2	22607974
Pubmed	Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.	MEF2A MEF2C	3.15e-04	12	77	2	28641113
Pubmed	Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1.	MEF2A MEF2C	3.15e-04	12	77	2	16424906
Pubmed	Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway.	MEF2A MEF2C	3.71e-04	13	77	2	21447557
Pubmed	Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation.	MEF2A MEF2C	4.33e-04	14	77	2	12130539
Pubmed	A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing.	MEF2A MEF2C	4.33e-04	14	77	2	8114702
Pubmed	Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.	CEACAM5 MDGA1 JAML IGDCC4	4.71e-04	162	77	4	25826454
Pubmed	Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development.	MEF2A MEF2C	4.99e-04	15	77	2	19782130
Pubmed	Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.	CELSR2 MDGA1	4.99e-04	15	77	2	20473291
Pubmed	Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of SARS-CoV-2.	CSPG4 TG	4.99e-04	15	77	2	36305765
Pubmed	The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction.	CEACAM5 NOD2	5.69e-04	16	77	2	23123061
Pubmed	Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.	CSPG4 LAMA3	5.69e-04	16	77	2	16880404
Pubmed	MD-2: the Toll 'gatekeeper' in endotoxin signalling.	MEF2A MEF2C NOD2	6.04e-04	74	77	3	15276183
Pubmed	Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development.	POLR2A SUFU	6.44e-04	17	77	2	32155439
Pubmed	MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders.	MEF2A MEF2C	6.44e-04	17	77	2	27779093
Pubmed	Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality.	MDGA1 MEF2C	6.44e-04	17	77	2	24441682
GeneFamily	Myocyte enhancer factor 2 proteins\|MADS box family	MEF2A MEF2C	4.66e-05	4	51	2	649
GeneFamily	Myocyte enhancer factor 2 proteins\|MADS box family	MEF2A MEF2C	7.76e-05	5	51	2	1086
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	CEACAM5 CD101 MDGA1 IGDCC4	1.09e-03	161	51	4	593
GeneFamily	Immunoglobulin like domain containing	CEACAM5 CD101 MDGA1 IGDCC4	2.13e-03	193	51	4	594
GeneFamily	NLR family	NLRP5 NOD2	2.25e-03	25	51	2	666
GeneFamily	Acyl-CoA synthetase family	ACSM2A ACSM2B	2.43e-03	26	51	2	40
ToppCell	NS-moderate-d_0-4-Myeloid-pDC\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	HMBOX1 FANCG MPEG1 EDEM1 ARHGEF17 JAML MEF2C	1.14e-08	177	69	7	de1ffe3df76100d46ca158bdd2fea2ebbd4656b4
ToppCell	Bronchus_Control_(B.)-Immune-TX-TRAM-1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	ASB9 ESYT1 CD101 MME HTRA4 SUFU	5.86e-07	195	69	6	dabf667875ed48fdce4f803f5ead39c71a6df42b
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	EIF2D EXD3 CUL7 LMBRD2 FCN3	8.39e-06	178	69	5	9d575902d3dbe33437c9d4200df093a741269803
ToppCell	Control-Endothelial-Endothelial-Activated_Alv_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HMBOX1 DHX58 PARP9 FCN3 MEF2C	9.59e-06	183	69	5	e81c142770f44fd902b0631bc360c5b5339d4c75
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BMP5 CSPG4 ARHGEF17 CPED1 MEF2C	1.01e-05	185	69	5	7092436b4db90289516ed130ade596e3021cffaf
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BMP5 CSPG4 ARHGEF17 CPED1 MEF2C	1.01e-05	185	69	5	a8ca7819066d5297ef6966e7f3e2c9f8a7673fdc
ToppCell	Bronchus_Control_(B.)-Immune-TX-DCs\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	NFKBIE MPEG1 EDEM1 JAML MEF2C	1.47e-05	200	69	5	e0beacb88bbdc353a3e883171613027feafcf1ef
ToppCell	PBMC-Mild-Myeloid-Neutrophil-Neutrophil-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PLIN4 MME BPIFA3 JAML	2.41e-05	108	69	4	c647f6595e7cccea91429a2377c9de6cc1acff4d
ToppCell	PBMC-Mild-Myeloid-Neutrophil-Neutrophil-Neu_0\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SYT14 INSRR MME JAML	5.28e-05	132	69	4	fe87cb22e13e17df29ad43327f1aa71361907582
ToppCell	PBMC-Mild-Myeloid-Neutrophil-Neutrophil-Neu_0\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYT14 INSRR MME JAML	5.28e-05	132	69	4	82f312a561d9fdd2ebc2c25926dfc2b333ff0a4f
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	INSRR HSD11B2 LINC02694 TG	5.93e-05	136	69	4	7cd22169fb71c6caf9feb203ad98be8480a54fba
ToppCell	343B-Myeloid-Dendritic-pDC\|343B / Donor, Lineage, Cell class and subclass (all cells)	MPEG1 EDEM1 JAML MEF2C	1.01e-04	156	69	4	547e2debfc09c07c049a880dded5fda7dd53e156
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Enterocyte_(Proximal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FANCG DHX58 MPEG1 ALOX15	1.09e-04	159	69	4	709b57f992a29878cc899d760d144d36cb5cb280
ToppCell	facs-Lung-EPCAM-3m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD101 MPEG1 JAML NOD2	1.11e-04	160	69	4	b73f07a0088936fbc3656a05710a67f38b4ae551
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD101 MPEG1 JAML NOD2	1.11e-04	160	69	4	b88876a58fea2066468e74dcc439c8561130a910
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD8-Tem/emra_CD8\|GI_small-bowel / Manually curated celltypes from each tissue	ASB9 MME ARHGEF17 CTSG	1.19e-04	163	69	4	1a8c79903ed416f286ebe8a9922233affbc55d82
ToppCell	NS-control-d_0-4-Myeloid-pDC\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MPEG1 CPED1 JAML MEF2C	1.25e-04	165	69	4	8b2d43d7c4ee07bd999bd51bc15117ce1fbb2d86
ToppCell	control-Myeloid-pDC\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MPEG1 CPED1 JAML MEF2C	1.25e-04	165	69	4	243c74adf8d993ff92acbff2768bdc5a1693eca3
ToppCell	normal_Lymph_Node-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	MPEG1 PARP9 JAML MEF2C	1.31e-04	167	69	4	820472887f43b42ae7e44513ca3d5465fb4f71a7
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EXD3 CEACAM5 LAMA3 HSD11B2	1.31e-04	167	69	4	7cb5b52aaa5b595fe2e97d9e175294ea8d63b165
ToppCell	NS-moderate-d_07-13-Myeloid-pDC\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MPEG1 CPED1 JAML MEF2C	1.34e-04	168	69	4	d03e91f0e0518b33555c0ec98124fc5ed0f11be5
ToppCell	LPS-antiTNF-Myeloid-Dendritic_cells-mDC\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CD101 MPEG1 JAML NOD2	1.34e-04	168	69	4	2dca1c4a33b6da9357fa3b2a523af19baab1c21c
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-T_cells-Th17\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HMBOX1 CD101 PARP9 JAML	1.34e-04	168	69	4	97bf074b91c9ae0064edc31fa4a2658ffdcfefa3
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DHX58 EIF2B5 IGLV10-54 SUFU	1.37e-04	169	69	4	c8691c4f707d46b2865fe46eabe24ea4d03c7b43
ToppCell	LPS-antiTNF-Myeloid-Dendritic_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LIPM CD101 MPEG1 JAML	1.40e-04	170	69	4	3cbeea6bfa500928c413b1c6129f6dedc769cd1e
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CSPG4 ARHGEF17 CPED1 MEF2C	1.40e-04	170	69	4	5570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NAT16 NFKBIE MME CPED1	1.44e-04	171	69	4	ff4ab7753320874600e5694f2681e672c144c294
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CSPG4 ARHGEF17 CPED1 MEF2C	1.47e-04	172	69	4	08a3fe536b1b064c5ee7779bc2b1115a5963a26b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CSPG4 ARHGEF17 CPED1 MEF2C	1.47e-04	172	69	4	553701349444eb366df3c11f54bb093434f153c6
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EXD3 CEACAM5 LAMA3 HSD11B2	1.50e-04	173	69	4	b75353fcbc9f8cdb21d4f10ddbc93a83fd797a3c
ToppCell	Globus_pallidus-Endothelial-MURAL-M1(Rgs5Acta2)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	BMP5 CSPG4 CPED1 JAML	1.50e-04	173	69	4	51328a60ffaf34fa0f7df6084d348b5efc9917f5
ToppCell	droplet-Kidney-nan-18m-Lymphocytic-CD45____plasma_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EDEM1 MDGA1 CPED1 TG	1.50e-04	173	69	4	60e427f6c7d953cef5f692043670ff0b49cdce72
ToppCell	Globus_pallidus-Endothelial-MURAL\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	BMP5 CSPG4 CPED1 JAML	1.50e-04	173	69	4	b77cd5dbda3a206922f20224f4e10a3bf712f7db
ToppCell	droplet-Kidney-nan-18m-Lymphocytic-plasma_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EDEM1 MDGA1 CPED1 TG	1.54e-04	174	69	4	c92eec5a14ca5269673582dd115ead8516e64c3e
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MPEG1 CTSG JAML NOD2	1.57e-04	175	69	4	e991ffa4d1d278a011592b9915cd35fe76db20cc
ToppCell	facs-Heart-RV-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP5 CSPG4 LAMA3 ARHGEF17	1.57e-04	175	69	4	d8e385320f554d974538b7cdc4f8e4767f1455f2
ToppCell	facs-Heart-RV-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP5 CSPG4 LAMA3 ARHGEF17	1.57e-04	175	69	4	cf15465855602ba135752c18755e3e058dbd42ec
ToppCell	10x3'2.3-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast-basophil\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	RGPD2 EXD3 ESYT1 LINC02694	1.60e-04	176	69	4	581d78811b2d99f38a2c7cc268aeb1cf932379c2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CSPG4 ARHGEF17 CPED1 MEF2C	1.64e-04	177	69	4	4943d040eee0f9dceaddc7498171281d170e271f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CSPG4 ARHGEF17 CPED1 MEF2C	1.64e-04	177	69	4	3f2272b577c862dba8ccfb41184054bbd0ace6f5
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	EIF2D CUL7 LMBRD2 FCN3	1.64e-04	177	69	4	eb0cfe8e9a91910f9979608ed47add48d98ce4dd
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HMBOX1 MAN2A1 INSRR HSD11B2	1.68e-04	178	69	4	51d2188406f04329311b2efd1108fc36617a860e
ToppCell	Striatum-Endothelial-MURAL\|Striatum / BrainAtlas - Mouse McCarroll V32	BMP5 CSPG4 CPED1 JAML	1.71e-04	179	69	4	3d58babf44e47462c3d4129dd2e94a2339fd7ce0
ToppCell	COVID-19-kidney-REN+Pericyte\|kidney / Disease (COVID-19 only), tissue and cell type	CSPG4 ARHGEF17 CPED1 MEF2C	1.71e-04	179	69	4	342c1cc4444f51b8dcb30d3adc98285a25669c6e
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSPG4 SUFU ARHGEF17 CPED1	1.71e-04	179	69	4	f99500c4a590e5152ded5862690f7fa614d64a80
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSPG4 SUFU ARHGEF17 CPED1	1.71e-04	179	69	4	7d61466181ab73088de3ec8a129d7cfa8cac7ecc
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)\|Striatum / BrainAtlas - Mouse McCarroll V32	BMP5 CSPG4 CPED1 JAML	1.71e-04	179	69	4	99167ac678cae5c35b1d4f4a81b32000437c00c2
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSPG4 SUFU ARHGEF17 CPED1	1.71e-04	179	69	4	6c98ce32cb55cf9cee557449e41b23bdb22f5efd
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BMP5 CNKSR2 CPED1 IGDCC4	1.75e-04	180	69	4	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	COVID-19-Heart-Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	BMP5 CSPG4 ARHGEF17 MEF2C	1.79e-04	181	69	4	33cac65ed1ea5e7bd72250495df4f850b143d5aa
ToppCell	11.5-Distal-Immune-Immune\|Distal / Age, Tissue, Lineage and Cell class	CD101 MPEG1 CTSG JAML	1.79e-04	181	69	4	193ee02f547a218b2fc13e1174ea4cff4f8a3450
ToppCell	PCW_05-06-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_monocyte_(14)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	MPEG1 CTSG JAML NOD2	1.79e-04	181	69	4	3457c1d431db4282be5a6243119e48960748ede7
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	HMBOX1 RGPD2 CNKSR2 LMBRD2	1.82e-04	182	69	4	21744c9c792e57d5d41b25986f419b2358c7057b
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA3 MPEG1 JAML MEF2C	1.82e-04	182	69	4	33afbb7c4352b03266501b1f4f0e751c12c7350d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CSPG4 ARHGEF17 CPED1 MEF2C	1.94e-04	185	69	4	51dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CSPG4 ARHGEF17 CPED1 MEF2C	1.94e-04	185	69	4	a8c02cec3c414f3a0da9f2d6d28ce563b0030705
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CSPG4 ARHGEF17 CPED1 MEF2C	2.02e-04	187	69	4	ec4b694487cc446999c7b27b119950a4f252c4b3
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CSPG4 ARHGEF17 CPED1 MEF2C	2.02e-04	187	69	4	48bfdb3504c3fefe5db3abac4b790c369680ab4e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CSPG4 ARHGEF17 CPED1 MEF2C	2.02e-04	187	69	4	530e4e6d91b5c0d9aa4543caa2b734a1674c5788
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CSPG4 ARHGEF17 CPED1 MEF2C	2.02e-04	187	69	4	958402fcc78f4c7a7d13d659d776f3817137975f
ToppCell	LAM-Lymphoid-pDC\|Lymphoid / Condition, Lineage and Cell class	MPEG1 CPED1 JAML MEF2C	2.02e-04	187	69	4	4d9ffd2bbdf1c9869e28991ce9331e4ccf3c0166
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CSPG4 ARHGEF17 CPED1 MEF2C	2.06e-04	188	69	4	b2d68a32314e9b099ed74d974079ad96359d1ae3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CSPG4 ARHGEF17 CPED1 MEF2C	2.11e-04	189	69	4	7fbe855bfdb47d35e040b04a80fe4b729a3764e8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CSPG4 ARHGEF17 CPED1 MEF2C	2.11e-04	189	69	4	06b35abecd29f902cf251fcc1f6ad33db7ab08a2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CSPG4 ARHGEF17 CPED1 MEF2C	2.11e-04	189	69	4	127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCell	Striatum-Endothelial\|Striatum / BrainAtlas - Mouse McCarroll V32	BMP5 ESYT1 CPED1 JAML	2.11e-04	189	69	4	95ee3b6d7fbbfcf91c780dfcd0926acec05f0a2d
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CSPG4 ARHGEF17 CPED1 MEF2C	2.11e-04	189	69	4	fac5c291a9a87418bb0878c3d624829bdbf1f428
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CSPG4 ARHGEF17 CPED1 MEF2C	2.11e-04	189	69	4	2cfb4d12f75678d1619f4743838a0e954bd57761
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CD101 MME CPED1 JAML	2.15e-04	190	69	4	0eef5a8bd88ef8a25a67d9dd522d9472fa4b3d2f
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CD101 MME CPED1 JAML	2.15e-04	190	69	4	2724e8f375d8d9f5f2a77444e0491af264babac5
ToppCell	droplet-Kidney-nan-21m-Epithelial-Stroma____kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLIN4 KRT78 CSPG4 ARHGEF17	2.15e-04	190	69	4	e04f47705851563515b6a66a2634cf7a574f7bda
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CSPG4 ARHGEF17 CPED1 MEF2C	2.15e-04	190	69	4	5681c211baeed4af82a2bbc13420f6a7b487581c
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LAMA3 CNKSR2 MEF2A MEF2C	2.15e-04	190	69	4	1bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCell	hematopoetic_progenitors-CD34+_CLP\|hematopoetic_progenitors / Lineage and Cell class	RNASEH2B MME MEF2A MEF2C	2.15e-04	190	69	4	117abdafd294c85ccb5d8ea907e3c0491b7200b2
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CD101 MME CPED1 JAML	2.15e-04	190	69	4	11fbd4e9f02750354b3aadf30edc991f8d4f8f41
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CD101 MME CPED1 JAML	2.15e-04	190	69	4	148d43dd72e2e22b2cd68e17fedae6bd98b32aee
ToppCell	Severe_COVID-19-Myeloid-TRAM1\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	CD101 MME CPED1 JAML	2.19e-04	191	69	4	bd641aab36276dd952a7265ee79ba455b38d8e6b
ToppCell	Bronchial_Brush-Immune-Luminal_Macrophages\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	MME HTRA4 CPED1 JAML	2.19e-04	191	69	4	88cb6f828407845918c946f8cee5f940cb81800a
ToppCell	COVID-19-Myeloid-DC2\|COVID-19 / Condition, Lineage and Cell class	CPED1 JAML MEF2A MEF2C	2.19e-04	191	69	4	1304ab7b5713f29f3966ffc020ea1b52e8e2f375
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CSPG4 ARHGEF17 CPED1 MEF2C	2.19e-04	191	69	4	7b0d42a877540dbb346a76a62403e0d5d3e07fa6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CSPG4 ARHGEF17 CPED1 MEF2C	2.19e-04	191	69	4	cd854b9c426924fdc84bf7f411f6dea447143e79
ToppCell	Nasal_Brush-Immune-Neutrophils\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	MPEG1 CPED1 JAML MEF2C	2.24e-04	192	69	4	20a7f7beb01df1c4f915ec2f9b5a9dbcab157187
ToppCell	10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-ELP\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	RNASEH2B ERAP2 MEF2A MEF2C	2.24e-04	192	69	4	38ec82aa2ec4f2c0a843e83f7fe54f6b2483ca3d
ToppCell	P07-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	BMP5 MME HSD11B2 CPED1	2.24e-04	192	69	4	0afb9dbe468e0be442c326e11c5fc0f699b32f23
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MPEG1 JAML MEF2C NOD2	2.28e-04	193	69	4	3e3d7cb3e7242ec9c9677e07e303835649852b52
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_0\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NFKBIE MPEG1 CPED1 NOD2	2.28e-04	193	69	4	6b3a2a32ec6dc96230cee4bbf03932f8a81e6683
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_0\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NFKBIE MPEG1 CPED1 NOD2	2.28e-04	193	69	4	b18c61e360f5f094f260007a56b189e2a48369e4
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BMP5 MME HSD11B2 CPED1	2.28e-04	193	69	4	8d05805295c5d3aa93aeb38be5fbefa81e1be1f0
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BMP5 MME HSD11B2 CPED1	2.28e-04	193	69	4	1b2cc627b2aa002b442358bd1188d470e67ce7d9
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LIPM ACSM2A MEF2C ACSM2B	2.28e-04	193	69	4	1b69f92c6a7a2516e393d3f3c371407ec791343d
ToppCell	Mild_COVID-19\|World / Disease group,lineage and cell class （2021.01.30）	DHX58 ERAP2 PARP9 JAML	2.28e-04	193	69	4	325b0768827bf8701bfb7f686bb11fd8b1a41a5c
ToppCell	PBMC-Mild\|PBMC / Compartment, Disease Groups and Clusters	DHX58 ERAP2 PARP9 MEF2A	2.33e-04	194	69	4	d1366b169d14011194e61d16b6b0953349febc78
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MPEG1 JAML MEF2C NOD2	2.33e-04	194	69	4	badefcec2af86cbcd97305f4843e84db0f3ebc66
ToppCell	10x5'-Liver-Myeloid_Dendritic\|Liver / Manually curated celltypes from each tissue	MPEG1 JAML MEF2C ALOX15	2.33e-04	194	69	4	e6391bc7073831847c469ef0b0c437118e1f151f
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CSPG4 ARHGEF17 CPED1 MEF2C	2.37e-04	195	69	4	e10b21e4dba4483efc4c82d6e395524246ca14a8
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CPED1 JAML MEF2A MEF2C	2.37e-04	195	69	4	7bb3bdfb8caaae357b1f7841d8d00936c4373dfe
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)-DC2_L.1.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NFKBIE MPEG1 JAML MEF2C	2.37e-04	195	69	4	c26c62522b6e0599f6a1256fefe26e1ed9badcc2
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NFKBIE MPEG1 JAML MEF2C	2.37e-04	195	69	4	60ba7be0c333ddc57885263a1103faffe06051c7
ToppCell	PBMC-Mild-cDC_1\|Mild / Compartment, Disease Groups and Clusters	PARP9 JAML MEF2A MEF2C	2.37e-04	195	69	4	674355ca00314bde90ef7f6ddb83afe2d5323130
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MPEG1 CPED1 JAML MEF2C	2.37e-04	195	69	4	42bfdff88da1d07828c0ad65d412fb1752f0cee4
Disease	X-21319 measurement	ACSM2A ACSM2B	5.55e-06	2	70	2	EFO_0800807
Disease	X-11478 measurement	ACSM2A ACSM2B	1.66e-05	3	70	2	EFO_0021242
Disease	relapsing-remitting multiple sclerosis (is_implicated_in)	CSPG4 NOD2	5.52e-05	5	70	2	DOID:2378 (is_implicated_in)
Disease	3-hydroxyhexanoate measurement	ACSM2A ACSM2B	5.52e-05	5	70	2	EFO_0800378
Disease	indoleacetoylcarnitine measurement	ACSM2A ACSM2B	8.27e-05	6	70	2	EFO_0800106
Disease	tumor necrosis factor receptor superfamily member EDAR measurement	SUFU MEF2C	3.61e-04	12	70	2	EFO_0008310
Disease	intellectual disability (implicated_via_orthology)	KDM5B MEF2A MEF2C	7.64e-04	75	70	3	DOID:1059 (implicated_via_orthology)
Disease	noggin measurement	SUFU MEF2C	8.28e-04	18	70	2	EFO_0021995
Disease	diabetes mellitus (implicated_via_orthology)	BMP5 INSRR	1.74e-03	26	70	2	DOID:9351 (implicated_via_orthology)
Disease	unipolar depression, depressive symptom measurement	CNKSR2 LINC02694	1.74e-03	26	70	2	EFO_0003761, EFO_0007006
Disease	attention deficit hyperactivity disorder (implicated_via_orthology)	MEF2A MEF2C	2.02e-03	28	70	2	DOID:1094 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QGGQGQVHLRLEWLS	ESYT1	436	Q9BSJ8
VQIQGNQVHHLGWLL	EIF2D	546	P41214
HGHQLSLRNLISQGW	ASB9	46	Q96DX5
GWIQLQVSDGQHQAT	CSPG4	1101	Q6UVK1
LVVGGVQWLNSNHLQ	CPED1	856	A4D0V7
QHQSGIVQLLWEAGT	AAMP	356	Q13685
NSRQLVSLQWGHQEV	ACSM2A	26	Q08AH3
SWRINGIPQQHTQVL	CEACAM5	626	P06731
LIQQTEGGTAWLLQH	CELSR2	2126	Q9HCU4
LWGLVNNAGHNEVVA	HSD11B2	161	P80365
QPEHQWTLLTTQGNI	IGDCC4	891	Q8TDY8
NLTLQIVQGHIEWQT	PARP9	316	Q8IXQ6
GITLQAWQQGITNHL	MPEG1	286	Q2M385
QTWHAQQKVGALLVQ	ARHGEF17	1136	Q96PE2
SLSGNKGNVWQQAHV	MDGA1	866	Q8NFP4
FWLGNENLHQLTLQG	FCN3	161	O75636
IRTWQKTHQGENNGL	LAMA3	2006	Q16787
QLIEGHQWLENNIGV	MAN2A1	266	Q16706
LQHGLVGGASNWISN	LIPM	96	Q5VYY2
SVQNILHWSQAVNSG	LIPM	301	Q5VYY2
TWQQLPGVALHNSVQ	HIPK1	761	Q86Z02
GTSHSLDLQLQNWQG	NFKBIE	356	O00221
LVGWLISGRKHQQQQ	BPIFA3	76	Q9BQP9
HNLIEQVSLGLGQPW	FBXO33	511	Q7Z6M2
LWQGVRVAAGAQIHQ	EIF2B5	396	Q13144
GISQSRISHWLLQQG	HMBOX1	196	Q6NT76
WNIQGLHTQGYNNIS	PGLYRP3	101	Q96LB9
GAQVQSQLLWHLQRQ	NAT16	306	Q8N8M0
LGWAELQFGNQTLHV	CUL7	1451	Q14999
WDLAGGQHLNGINTL	MME	631	P08473
TKWHLLQQQGLSGSQ	KRT78	141	Q8N1N4
AGSNNQVQLWLVGQH	ALOX15	16	P16050
QVQLWLVGQHGEAAL	ALOX15	21	P16050
ALHLGSVTGWQQQHL	MEF2C	341	Q06413
NWQHRAQQLLSSGNL	KDM5B	1261	Q9UGL1
LHWVSLLGQQPNATT	NLRP5	666	P59047
HLLQGQAWVQLGAQK	FANCG	456	O15287
LGQVSAWQQHHLGQA	MEF2A	361	Q02078
QGLQWGTQQILSEHT	NR0B1	401	P51843
LGIGQNWSTISQQAL	ERVK-10	396	P87889
LGIGQNWSTISQQAL	ERVK-19	396	Q9YNA8
LGIGQNWSTISQQAL	ERVK-21	396	P62683
LGIGQNWSTISQQAL	ERVK-24	396	P63145
LGIGQNWSTISQQAL	ERVK-6	396	Q7LDI9
LGIGQNWSTISQQAL	ERVK-7	396	P63130
LGIGQNWSTISQQAL	ERVK-8	396	P62685
LGIGQNWSTISQQAL	ERVK-9	396	P63126
LGIGQNWSTISQQAL	HERVK_113	396	P62684
GLIITNAHVVRNQQW	HTRA4	211	P83105
QQGSIQDINHRVWVL	IL36A	11	Q9UHA7
QLIRITHNGTIEWGN	CD101	591	Q93033
HSLLLWLQQQQGLQT	DHX58	381	Q96C10
SNHWVINPQNNLGLQ	BMP5	256	P22003
LLGNVVNIQTGHWVG	EDEM1	346	Q92611
VNIQTGHWVGKQSGL	EDEM1	351	Q92611
NIVGNQGAAWLQQHQ	IGLV10-54	46	A0A075B6I4
WKAGGSIQATIQNVH	ITIH6	331	Q6UXX5
NLQQLGSWVAAGLTI	INSRR	421	P14616
EGHGWDQLITQLNQN	ERAP2	636	Q6P179
WGSNINVTLGAHNIQ	CTSG	66	P08311
AWQGLEQLLEGLQHN	PLIN4	1326	Q96Q06
NRTGGNSWQVHLVLL	SYT14	291	Q8NB59
QLQTIGIAAANTWGL	LMBRD2	181	Q68DH5
GQHGNNVQWQALSEL	RGPD2	301	P0DJD1
SQSWGHFQNRVNLVG	JAML	196	Q86YT9
IQGALLHQDVNTAWN	PRORP	251	O15091
LGIGQNWSTISQQAL	ERVK-9	396	P63128
GWAVLTGPQQQSHQL	SUPT20HL2	656	P0C7V6
NSRQLVSLQWGHQEV	ACSM2B	26	Q68CK6
NHQTVVGWQLKNLVN	CNKSR2	266	Q8WXI2
LTQGHQQELRDWNLG	LINC02694	56	Q8NAA6
LKWQQTHRVGAGLQN	USP42	101	Q9H9J4
HQSLRWLSLVGNNIG	NOD2	926	Q9HC29
HSWFINQSVQSGGLL	RNASEH2B	71	Q5TBB1
NIQTVINNWLLIEGH	POLR2A	671	P24928
LGVSAWLNHLNELGQ	TBC1D16	396	Q8TBP0
EELHSAQQWNGQGIL	SUFU	206	Q9UMX1
TQQQWHLQGLGRSEL	TLE7	71	A0A1W2PR48
LQWGTIVQGILQSQG	RHAG	91	Q02094
CQRPQLWQTIQTQGH	TG	1281	P01266
LWQTIQTQGHFQLQL	TG	1286	P01266
TLQQLGTVGLWQFLH	UHRF1BP1	1221	Q6BDS2
NQAGEIQVWSLQQGH	WDR87	221	Q6ZQQ6
SQENWTDHVQGLVGQ	EXD3	281	Q8N9H8