Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	6-phosphofructokinase activity	PFKL PFKM	3.12e-05	3	65	2	GO:0003872
GeneOntologyMolecularFunction	fructose-6-phosphate binding	PFKL PFKM	1.04e-04	5	65	2	GO:0070095
GeneOntologyMolecularFunction	fructose binding	PFKL PFKM	1.55e-04	6	65	2	GO:0070061
GeneOntologyMolecularFunction	phosphofructokinase activity	PFKL PFKM	2.17e-04	7	65	2	GO:0008443
GeneOntologyMolecularFunction	calcium:sodium antiporter activity	SLC8A1 SLC3A2	4.62e-04	10	65	2	GO:0005432
GeneOntologyMolecularFunction	calcium ion binding	THBS1 SLC8A1 FBN1 DSC3 CADPS FAT3 PCDHB3 PCDHB2 PCDHA1	6.83e-04	749	65	9	GO:0005509
GeneOntologyMolecularFunction	calcium:monoatomic cation antiporter activity	SLC8A1 SLC3A2	7.95e-04	13	65	2	GO:0015368
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	DSC3 FAT3 PCDHB3 PCDHB2 PCDHA1 SDK1	2.72e-05	187	65	6	GO:0007156
GeneOntologyBiologicalProcess	cell-cell adhesion via plasma-membrane adhesion molecules	DSC3 FAT3 TENM1 PCDHB3 PCDHB2 PCDHA1 SDK1	5.68e-05	313	65	7	GO:0098742
GeneOntologyBiologicalProcess	calcium ion export	SLC8A1 ATP2B4	5.84e-05	4	65	2	GO:1901660
GeneOntologyCellularComponent	6-phosphofructokinase complex	PFKL PFKM	2.85e-05	3	65	2	GO:0005945
GeneOntologyCellularComponent	phagophore assembly site	SQSTM1 ATG9A RB1CC1	2.42e-04	39	65	3	GO:0000407
MousePheno	abnormal fluid regulation	DNAAF2 KRT2 NPR1 SLC8A1 FBN1 ADAMTS3 JMJD6 NUP133 MLLT10 RB1CC1 MYO18B NFAT5 TP73 FAN1	1.57e-06	826	53	14	MP:0001784
MousePheno	abnormal heart ventricle morphology	LRIG3 THBS1 NPR1 SLC8A1 FBN1 ADAMTS3 JMJD6 FAT3 FNIP1 RB1CC1 PFKM NFAT5	3.16e-05	793	53	12	MP:0005294
MousePheno	abnormal muscle morphology	ADAMTS10 LRIG3 THBS1 NPR1 SLC8A1 FBN1 JMJD6 FAT3 FNIP1 RB1CC1 MYO18B PFKM NFAT5 CD163	4.45e-05	1106	53	14	MP:0002108
MousePheno	edema	DNAAF2 NPR1 SLC8A1 ADAMTS3 JMJD6 NUP133 MLLT10 RB1CC1 NFAT5 TP73	5.52e-05	581	53	10	MP:0001785
MousePheno	abnormal blood circulation	LRIG3 THBS1 NPR1 SLC8A1 FBN1 ADAMTS3 ARID4A FNIP1 MLLT10 RB1CC1 MYO18B TP73	5.87e-05	845	53	12	MP:0002128
MousePheno	abnormal cardiac muscle tissue morphology	NPR1 SLC8A1 FBN1 JMJD6 FNIP1 RB1CC1 MYO18B PFKM NFAT5	8.19e-05	489	53	9	MP:0010630
MousePheno	abnormal respiratory system physiology	DNAAF2 THBS1 NPR1 FBN1 ARID4A CADPS FAT3 FNIP1 IKZF1 PTGER2 CD163 TP73	1.04e-04	897	53	12	MP:0002133
MousePheno	abnormal heart ventricle wall morphology	SLC8A1 FBN1 FAT3 FNIP1 RB1CC1 PFKM NFAT5	1.19e-04	296	53	7	MP:0031532
MousePheno	increased lung compliance	FBN1 FAT3 FNIP1	1.26e-04	26	53	3	MP:0010895
MousePheno	abnormal gland physiology	THBS1 NPR1 SLC8A1 BRCA1 ARID4A CADPS IKZF1 PFKM WDR13 TP73	2.31e-04	691	53	10	MP:0002164
MousePheno	abnormal endocrine gland morphology	LRIG3 THBS1 SLC8A1 FBN1 BRCA1 ADAMTS3 JMJD6 FAT3 FNIP1 IKZF1 NFAT5 WDR13 TP73	2.63e-04	1144	53	13	MP:0013560
MousePheno	fetal cardiomyocyte disarray	SLC8A1 MYO18B	2.93e-04	7	53	2	MP:0031613
Domain	PCDHB2/3	PCDHB3 PCDHB2	1.16e-05	2	64	2	IPR030735
Domain	PHOSPHOFRUCTOKINASE	PFKL PFKM	3.46e-05	3	64	2	PS00433
Domain	6-Pfructokinase_euk	PFKL PFKM	3.46e-05	3	64	2	IPR009161
Domain	Phosphofructokinase_CS	PFKL PFKM	3.46e-05	3	64	2	IPR015912
Domain	PFK	PFKL PFKM	3.46e-05	3	64	2	PF00365
Domain	ATP_PFK	PFKL PFKM	3.46e-05	3	64	2	IPR022953
Domain	Phosphofructokinase_dom	PFKL PFKM	3.46e-05	3	64	2	IPR000023
Domain	Cadherin_CS	DSC3 FAT3 PCDHB3 PCDHB2 PCDHA1	3.58e-05	109	64	5	IPR020894
Domain	CADHERIN_1	DSC3 FAT3 PCDHB3 PCDHB2 PCDHA1	4.25e-05	113	64	5	PS00232
Domain	Cadherin	DSC3 FAT3 PCDHB3 PCDHB2 PCDHA1	4.25e-05	113	64	5	PF00028
Domain	CADHERIN_2	DSC3 FAT3 PCDHB3 PCDHB2 PCDHA1	4.44e-05	114	64	5	PS50268
Domain	-	DSC3 FAT3 PCDHB3 PCDHB2 PCDHA1	4.44e-05	114	64	5	2.60.40.60
Domain	CA	DSC3 FAT3 PCDHB3 PCDHB2 PCDHA1	4.63e-05	115	64	5	SM00112
Domain	Cadherin-like	DSC3 FAT3 PCDHB3 PCDHB2 PCDHA1	4.82e-05	116	64	5	IPR015919
Domain	Cadherin	DSC3 FAT3 PCDHB3 PCDHB2 PCDHA1	5.23e-05	118	64	5	IPR002126
Domain	EGF-like_CS	THBS1 FBN1 FAT3 TENM1 ASTN1 EPHA8	2.67e-04	261	64	6	IPR013032
Domain	EGF_2	THBS1 FBN1 FAT3 TENM1 ASTN1 EPHA8	2.90e-04	265	64	6	PS01186
Domain	EGF_3	THBS1 FBN1 FAT3 TENM1 ASTN1	1.26e-03	235	64	5	PS50026
Domain	EGF	THBS1 FBN1 FAT3 TENM1 ASTN1	1.26e-03	235	64	5	SM00181
Domain	TSP_1	ADAMTS10 THBS1 ADAMTS3	1.32e-03	63	64	3	PF00090
Domain	TSP1	ADAMTS10 THBS1 ADAMTS3	1.44e-03	65	64	3	SM00209
Domain	TSP1_rpt	ADAMTS10 THBS1 ADAMTS3	1.44e-03	65	64	3	IPR000884
Domain	TSP1	ADAMTS10 THBS1 ADAMTS3	1.44e-03	65	64	3	PS50092
Domain	Cadherin_2	PCDHB3 PCDHB2 PCDHA1	1.44e-03	65	64	3	PF08266
Domain	Cadherin_N	PCDHB3 PCDHB2 PCDHA1	1.44e-03	65	64	3	IPR013164
Domain	A/G_cyclase_CS	NPR1 ADCY3	1.52e-03	17	64	2	IPR018297
Domain	EGF-like_dom	THBS1 FBN1 FAT3 TENM1 ASTN1	1.63e-03	249	64	5	IPR000742
Domain	Nucleotide_cyclase	NPR1 ADCY3	1.71e-03	18	64	2	IPR029787
Domain	-	NPR1 ADCY3	1.71e-03	18	64	2	3.30.70.1230
Domain	EGF_1	THBS1 FBN1 FAT3 TENM1 ASTN1	1.80e-03	255	64	5	PS00022
Domain	PLAC	ADAMTS10 ADAMTS3	1.90e-03	19	64	2	PS50900
Domain	GUANYLATE_CYCLASE_1	NPR1 ADCY3	1.90e-03	19	64	2	PS00452
Domain	Guanylate_cyc	NPR1 ADCY3	1.90e-03	19	64	2	PF00211
Domain	GUANYLATE_CYCLASE_2	NPR1 ADCY3	1.90e-03	19	64	2	PS50125
Domain	PLAC	ADAMTS10 ADAMTS3	1.90e-03	19	64	2	IPR010909
Domain	A/G_cyclase	NPR1 ADCY3	1.90e-03	19	64	2	IPR001054
Domain	CYCc	NPR1 ADCY3	1.90e-03	19	64	2	SM00044
Domain	ADAM_spacer1	ADAMTS10 ADAMTS3	2.79e-03	23	64	2	IPR010294
Domain	ADAM_spacer1	ADAMTS10 ADAMTS3	2.79e-03	23	64	2	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTS10 ADAMTS3	3.04e-03	24	64	2	IPR013273
Domain	EGF_CA	THBS1 FBN1 FAT3	3.21e-03	86	64	3	PF07645
Domain	-	THBS1 NBEAL1 FAT3	4.24e-03	95	64	3	2.60.120.200
Pubmed	FIP200 regulates targeting of Atg16L1 to the isolation membrane.	SQSTM1 ATG9A RB1CC1	5.19e-07	9	65	3	23392225
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	LRIG3 JMJD6 CADPS STARD9 FNIP1 MAPKBP1 NFAT5 ADCY3	9.26e-07	407	65	8	12693553
Pubmed	Exome sequencing supports a de novo mutational paradigm for schizophrenia.	THBS1 ADAMTS3 MAGEC1 RB1CC1	9.65e-07	40	65	4	21822266
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	DSC3 NBEAL1 SQSTM1 ATG9A RB1CC1 WDR13 SLC3A2	1.07e-06	285	65	7	34369648
Pubmed	WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.	SQSTM1 ATG9A RB1CC1	1.35e-06	12	65	3	24954904
Pubmed	A primary expression map of the chromosome 15q15 region containing the recessive form of limb-girdle muscular dystrophy (LGMD2A) gene.	THBS1 FBN1 STARD9	3.43e-06	16	65	3	7633422
Pubmed	Insulin specifically regulates expression of liver and muscle phosphofructokinase isoforms.	PFKL PFKM	3.44e-06	2	65	2	29655163
Pubmed	CCCP-Induced LC3 lipidation depends on Atg9 whereas FIP200/Atg13 and Beclin 1/Atg14 are dispensable.	ATG9A RB1CC1	3.44e-06	2	65	2	23402761
Pubmed	The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella.	ATG9A RB1CC1	3.44e-06	2	65	2	21525242
Pubmed	Isozyme analysis of human polymorphonuclear leukocyte phosphofructokinase from insulin resistant individuals.	PFKL PFKM	3.44e-06	2	65	2	8780720
Pubmed	A novel role of ATG9A and RB1CC1/FIP200 in mediating cell-death checkpoints to repress TNF cytotoxicity.	ATG9A RB1CC1	3.44e-06	2	65	2	36892222
Pubmed	The molecular mechanism of the inherited phosphofructokinase deficiency associated with hemolysis and myopathy.	PFKL PFKM	3.44e-06	2	65	2	6444532
Pubmed	Ikaros and its interacting partner CtBP target the metalloprotease ADAMTS10 to modulate pituitary cell function.	ADAMTS10 IKZF1	3.44e-06	2	65	2	27815209
Pubmed	BRCA1-associated epigenetic regulation of p73 mediates an effector pathway for chemosensitivity in ovarian carcinoma.	BRCA1 TP73	3.44e-06	2	65	2	20807817
Pubmed	Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells.	SQSTM1 RB1CC1	3.44e-06	2	65	2	25052093
Pubmed	ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts.	ADAMTS10 FBN1	3.44e-06	2	65	2	21402694
Pubmed	TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation.	PFKL TP73	3.44e-06	2	65	2	30409970
Pubmed	The glycolytic enzyme phosphofructokinase-1 assembles into filaments.	PFKL PFKM	3.44e-06	2	65	2	28646105
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	ADAMTS10 FBH1 ARID4A SANBR HACL1 ATG9A ZNF236 ADCY3 TP73 FAN1	8.04e-06	925	65	10	28986522
Pubmed	Functional expression of human mutant phosphofructokinase in yeast: genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency.	PFKL PFKM	1.03e-05	3	65	2	7825568
Pubmed	Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.	ADAMTS10 FBN1	1.03e-05	3	65	2	30201140
Pubmed	FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates.	SQSTM1 RB1CC1	1.03e-05	3	65	2	30853400
Pubmed	Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system.	PFKL PFKM	1.03e-05	3	65	2	6444721
Pubmed	Genomic organization, 5'flanking region and tissue-specific expression of mouse phosphofructokinase C gene.	PFKL PFKM	1.03e-05	3	65	2	11137296
Pubmed	Caveolin-1 depletion attenuates hepatic fibrosis via promoting SQSTM1-mediated PFKL degradation in HSCs.	SQSTM1 PFKL	1.03e-05	3	65	2	37116593
Pubmed	Phosphofructokinase isozyme expression during myoblast differentiation.	PFKL PFKM	1.03e-05	3	65	2	2521854
Pubmed	Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches.	PFKL PFKM	1.03e-05	3	65	2	33141153
Pubmed	Phosphofructokinase (PFK) isozymes in man. I. Studies of adult human tissues.	PFKL PFKM	1.03e-05	3	65	2	156693
Pubmed	Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system.	PFKL PFKM	1.03e-05	3	65	2	6451249
Pubmed	Correlation of BRCA1, TXR1 and TSP1 mRNA expression with treatment outcome to docetaxel-based first-line chemotherapy in patients with advanced/metastatic non-small-cell lung cancer.	THBS1 BRCA1	1.03e-05	3	65	2	21157449
Pubmed	Non-canonical function of FIP200 is required for neural stem cell maintenance and differentiation by limiting TBK1 activation and p62 aggregate formation.	SQSTM1 RB1CC1	1.03e-05	3	65	2	34903812
Pubmed	FIP200 Suppresses Immune Checkpoint Therapy Responses in Breast Cancers by Limiting AZI2/TBK1/IRF Signaling Independent of Its Canonical Autophagy Function.	BRCA1 RB1CC1	1.03e-05	3	65	2	32580962
Pubmed	Autophagy gene FIP200 in neural progenitors non-cell autonomously controls differentiation by regulating microglia.	SQSTM1 RB1CC1	1.03e-05	3	65	2	28634261
Pubmed	Characterization of the enzymatic defect in late-onset muscle phosphofructokinase deficiency. New subtype of glycogen storage disease type VII.	PFKL PFKM	1.03e-05	3	65	2	2960695
Pubmed	FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells.	SQSTM1 RB1CC1	1.03e-05	3	65	2	20716775
Pubmed	Immune-Phenotyping and Transcriptomic Profiling of Peripheral Blood Mononuclear Cells From Patients With Breast Cancer: Identification of a 3 Gene Signature Which Predicts Relapse of Triple Negative Breast Cancer.	THBS1 CD163	1.03e-05	3	65	2	30254632
Pubmed	Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer.	BRCA1 RB1CC1	1.03e-05	3	65	2	29938573
Pubmed	BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62.	SQSTM1 DNAJA2 TNKS1BP1 MAGEC1 SLC3A2	1.13e-05	156	65	5	32850835
Pubmed	Methylation biomarkers for pleomorphic lobular breast cancer - a short report.	BRCA1 TP73	2.06e-05	4	65	2	26392358
Pubmed	Weill-Marchesani Syndrome	ADAMTS10 FBN1	2.06e-05	4	65	2	20301293
Pubmed	Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity.	BRCA1 SQSTM1	2.06e-05	4	65	2	20616007
Pubmed	A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.	FAT3 TENM1 SDK1 EPHA8	2.63e-05	91	65	4	28558017
Pubmed	Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.	INTS6L THBS1 SQSTM1 DNAJA2 NFAT5 ADCY3	3.08e-05	321	65	6	32098917
Pubmed	CDC25A, VAV1, TP73, BRCA1 and ZAP70 gene overexpression correlates with radiation response in colorectal cancer.	BRCA1 TP73	3.43e-05	5	65	2	21344162
Pubmed	Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.	SQSTM1 RB1CC1	3.43e-05	5	65	2	25040165
Pubmed	A Case Study on the Keap1 Interaction with Peptide Sequence Epitopes Selected by the Peptidomic mRNA Display.	SQSTM1 ASTN1	3.43e-05	5	65	2	31169361
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	KRT2 WASHC4 DSC3 SQSTM1 DNAJA2 SHCBP1 NUP133 PFKL PFKM WDR13 SLC3A2	3.85e-05	1353	65	11	29467282
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	LRIG3 BRCA1 JMJD6 CADPS SQSTM1 FAT3 DNAJA2 WDR13 TP73 SP140	4.01e-05	1116	65	10	31753913
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	DNAAF2 THBS1 CADPS STARD9 DNAJA2 TENM1 PFKL	4.85e-05	513	65	7	25798074
Pubmed	RB1CC1 protein suppresses type II collagen synthesis in chondrocytes and causes dwarfism.	SQSTM1 RB1CC1	5.13e-05	6	65	2	22049074
Pubmed	Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide.	SQSTM1 RB1CC1	5.13e-05	6	65	2	26929451
Pubmed	The tight-skin (Tsk) mutation is closely linked to B2m on mouse chromosome 2.	THBS1 FBN1	5.13e-05	6	65	2	8111131
Pubmed	Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange.	SLC8A1 ATP2B4	5.13e-05	6	65	2	12767889
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	LRIG3 THBS1 NPR1 SQSTM1 SDK1	5.15e-05	214	65	5	22199357
Pubmed	Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.	NPR1 SQSTM1	7.18e-05	7	65	2	28322253
Pubmed	A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers.	SQSTM1 DNAJA2 HDX IKZF1	9.09e-05	125	65	4	21654808
Pubmed	Retinal transcriptome of neonatal mice after optic nerve injury.	THBS1 FBN1	9.56e-05	8	65	2	37252932
Pubmed	Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy.	SQSTM1 ATG9A	9.56e-05	8	65	2	32556086
Pubmed	Autophagy Is Required for Maturation of Surfactant-Containing Lamellar Bodies in the Lung and Swim Bladder.	SQSTM1 RB1CC1	1.23e-04	9	65	2	33296658
Pubmed	Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice.	PFKL PFKM	1.23e-04	9	65	2	21074528
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZNF7 THBS1 FBN1 FBH1 WASHC4 CADPS DNAJA2 ASTN1 WDR13 FAN1	1.29e-04	1285	65	10	35914814
Pubmed	Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome.	SQSTM1 ATG9A	1.53e-04	10	65	2	31142229
Pubmed	N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis.	BRCA1 SQSTM1	1.53e-04	10	65	2	29507222
Pubmed	Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis.	SQSTM1 RB1CC1	1.53e-04	10	65	2	26764600
Pubmed	p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding.	SQSTM1 RB1CC1	1.53e-04	10	65	2	21220506
Pubmed	Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin.	SQSTM1 RB1CC1	1.53e-04	10	65	2	24100292
Pubmed	ADAMTS: a novel family of extracellular matrix proteases.	ADAMTS10 ADAMTS3	1.53e-04	10	65	2	11167130
Pubmed	Genetic variants associated with breast size also influence breast cancer risk.	CADPS ZNF277 ATP2B4	1.70e-04	57	65	3	22747683
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHB3 PCDHB2 PCDHA1	1.70e-04	57	65	3	32633719
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHB3 PCDHB2 PCDHA1	1.79e-04	58	65	3	30377227
Pubmed	Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgenesis.	SQSTM1 ATG9A	1.87e-04	11	65	2	28513333
Pubmed	Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation.	SQSTM1 RB1CC1	1.87e-04	11	65	2	26764599
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	THBS1 DNAJA2 SHCBP1 MAGEC1 TP73	1.88e-04	282	65	5	23667531
Pubmed	A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation.	NFAT5 PMF1 SP140	2.08e-04	61	65	3	32911434
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	CADPS SQSTM1 DNAJA2 ETFB SANBR TENM1 ASTN1 PFKL SLC3A2	2.58e-04	1139	65	9	36417873
Pubmed	Protocadherins.	PCDHB3 PCDHB2	2.65e-04	13	65	2	12231349
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHB3 PCDHB2 PCDHA1	2.86e-04	68	65	3	11230163
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	THBS1 NPR1 WASHC4 SQSTM1 DNAJA2 SHCBP1 NUP133 TNKS1BP1 PMF1	2.86e-04	1155	65	9	20360068
Pubmed	FIP200 is required for maintenance and differentiation of postnatal neural stem cells.	SQSTM1 RB1CC1	3.08e-04	14	65	2	23542691
Pubmed	Tbr2 expression in Cajal-Retzius cells and intermediate neuronal progenitors is required for morphogenesis of the dentate gyrus.	ADCY3 TP73	3.08e-04	14	65	2	23447624
Pubmed	FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation.	SQSTM1 FNIP1	3.08e-04	14	65	2	25126726
Pubmed	Cytoplasmic short linear motifs in ACE2 and integrin β3 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy.	SQSTM1 ATG9A	3.08e-04	14	65	2	33436498
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	THBS1 FBN1 PMF1	3.25e-04	71	65	3	33541421
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHB3 PCDHB2 PCDHA1	3.39e-04	72	65	3	10380929
Pubmed	Huntingtin functions as a scaffold for selective macroautophagy.	SQSTM1 RB1CC1	3.56e-04	15	65	2	25686248
Pubmed	Age-regulated function of autophagy in the mouse inner ear.	SQSTM1 ATG9A	3.56e-04	15	65	2	26235979
Pubmed	ADAMTS2 promotes radial migration by activating TGF-β signaling in the developing neocortex.	ADAMTS10 ADAMTS3	3.56e-04	15	65	2	38871984
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	LRIG3 WASHC4 TENM1 FNIP1 ATG9A SLC3A2	3.60e-04	504	65	6	34432599
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHB3 PCDHB2 PCDHA1	3.67e-04	74	65	3	10817752
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTS10 THBS1 ADAMTS3	3.82e-04	75	65	3	20637190
Pubmed	Role of BRCA1 in brain development.	BRCA1 TP73	4.06e-04	16	65	2	24639535
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHB3 PCDHB2 PCDHA1	4.13e-04	77	65	3	10835267
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	KRT2 ETFB NUP133 IKZF1 PFKL	4.43e-04	340	65	5	29478914
Pubmed	ATF4 May Be Essential for Adaption of the Ocular Lens to Its Avascular Environment.	SQSTM1 SLC3A2	4.59e-04	17	65	2	37998373
Pubmed	Mapping of five subtype genes for muscarinic acetylcholine receptor to mouse chromosomes.	THBS1 SLC3A2	4.59e-04	17	65	2	10549128
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHB3 PCDHB2 PCDHA1	4.62e-04	80	65	3	10716726
Pubmed	Proteomic analysis identifies novel binding partners of BAP1.	SQSTM1 DNAJA2 RB1CC1	4.62e-04	80	65	3	34591877
Pubmed	High-throughput screening of functional deubiquitinating enzymes in autophagy.	SQSTM1 RB1CC1	5.16e-04	18	65	2	32453962
Pubmed	Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching.	PFKL PFKM	5.16e-04	18	65	2	28049690
Pubmed	Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.	ADAMTS10 FBN1	5.16e-04	18	65	2	35503090
Interaction	ITIH5 interactions	BRCA1 SQSTM1 RB1CC1	8.95e-06	13	65	3	int:ITIH5
Interaction	APEH interactions	BRCA1 JMJD6 DNAJA2 PFKL PFKM	8.99e-06	87	65	5	int:APEH
Cytoband	Ensembl 112 genes in cytogenetic band chr16q11	DNAJA2 SHCBP1	1.29e-04	12	65	2	chr16q11
Cytoband	5q31	PCDHB3 PCDHB2 PCDHA1	5.97e-04	115	65	3	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	PCDHB3 PCDHB2 FNIP1 PCDHA1	8.63e-04	298	65	4	chr5q31
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	CSRNP2 BRCA1 IKZF1 RB1CC1 PFKM	1.27e-04	181	49	5	694
GeneFamily	Clustered protocadherins	PCDHB3 PCDHB2 PCDHA1	6.94e-04	64	49	3	20
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS10 ADAMTS3	1.19e-03	19	49	2	50
GeneFamily	Autophagy related	ATG9A RB1CC1	3.60e-03	33	49	2	1022
Coexpression	GSE37416_0H_VS_6H_F_TULARENSIS_LVS_NEUTROPHIL_DN	FBN1 NBEAL1 ZNF277 SQSTM1 DNAJA2 SLC3A2	9.82e-06	198	65	6	M5346
Coexpression	GSE1791_CTRL_VS_NEUROMEDINU_IN_T_CELL_LINE_6H_DN	DNAAF2 THBS1 ETFB NUP133 PTGER2 NFAT5	1.01e-05	199	65	6	M6172
Coexpression	KANG_DOXORUBICIN_RESISTANCE_DN	WASHC4 RB1CC1 NFAT5	1.37e-05	19	65	3	M3323
Coexpression	OHM_METHYLATED_IN_ADULT_CANCERS	THBS1 BRCA1 TP73	4.08e-05	27	65	3	M1233
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_top-relative-expression-ranked_1000	THBS1 DSC3 ADAMTS3 ARID4A CADPS FAT3 TENM1 NUP133 PCDHB3 FNIP1 ASTN1 ICE1	6.39e-06	836	64	12	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_1000
ToppCell	(07)_Ionocytes-(1)_GFP\|(07)_Ionocytes / shred by cell type by condition	INTS6L THBS1 SLC8A1 ATG9A MYO18B	2.45e-06	147	65	5	d398f49553ece2786c51e16e4bee028fb3833149
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 FBN1 ADAMTS3 FAT3 SDK1	8.35e-06	189	65	5	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 FBN1 ADAMTS3 FAT3 SDK1	8.79e-06	191	65	5	b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 FBN1 ADAMTS3 FAT3 SDK1	9.01e-06	192	65	5	6f4ef24dab544681304b7f8a9dc073e7edaa4cf5
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 FBN1 ADAMTS3 FAT3 SDK1	9.48e-06	194	65	5	89b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell	Parenchymal-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FBN1 JMJD6 FAT3 ADCY3 SP140	1.07e-05	199	65	5	6f5ef959b51eccf1ffc2e5ddf0d83c62ca2257b2
ToppCell	Parenchymal-NucSeq-Stromal-Peri/Epineurial_\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FBN1 JMJD6 FAT3 ADCY3 SP140	1.07e-05	199	65	5	1aa99d21bf61b86df4a966dc47634044430aa39f
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6-Excitatory_Neuron.Slc17a7.Bcl6-Ptgfr_(Postsubiculum)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	KRT2 PCDHB2 PCDHA1 ATG9A	1.29e-05	98	65	4	9865a9de11dea6db0b75dd04fee523cd2da44766
ToppCell	droplet-Liver-nan-3m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC8A1 FBH1 IKZF1 CD163	3.59e-05	127	65	4	39fa20a55de3af1a62ab5dfa4877879db3935ac2
ToppCell	Adult-Immune-mast_cell-D122\|Adult / Lineage, Cell type, age group and donor	INTS6L DNAAF2 CADPS TENM1	7.79e-05	155	65	4	7c9de0591d1bf756b8e268b278bbe10bd5415dcd
ToppCell	Adult-Immune-mast_cell\|Adult / Lineage, Cell type, age group and donor	INTS6L CADPS TENM1 IKZF1	9.02e-05	161	65	4	44f5c0256b3ce264a6c7b62740f32dcd45ee052d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC8A1 ADAMTS3 SHCBP1 SDK1	9.24e-05	162	65	4	285e6d553f485fd9f1075c4e1b940da251b5ea35
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC8A1 PTGER2 ADCY3 CD163	1.06e-04	168	65	4	4ae9e9d93bcd6f4d5815e57fd5afa7a3398a0ec1
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC8A1 PTGER2 ADCY3 CD163	1.06e-04	168	65	4	04e168fe1d6f5f9e3d3bf9d7c13e800e3594868a
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC8A1 PTGER2 ADCY3 CD163	1.09e-04	169	65	4	454b92b9b67299a64278c010db033ca5b9d217a0
ToppCell	COVID-19-Heart-CM_+_Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	SLC8A1 IKZF1 MYO18B CD163	1.11e-04	170	65	4	4232fe937909f93d3736988c707b8f95ce993398
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRIG3 WASHC4 HACL1 MAPKBP1	1.11e-04	170	65	4	8465c3069bbc08705d070927e712b6bc85ac7c5b
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	FBN1 TENM1 IKZF1 SP140	1.24e-04	175	65	4	06eace2e681980456299167b48bd49bcfea5e940
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC8A1 ASTN1 SDK1 ADCY3	1.24e-04	175	65	4	d52794426f2703a80e91ae0a8ff2d8e0ce4aa4a8
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC8A1 ASTN1 SDK1 ADCY3	1.24e-04	175	65	4	454f03e6109d65f5db08dbb41ecc19ffb6bbc4e0
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRIG3 ADAMTS3 FAT3 FRMPD2	1.33e-04	178	65	4	0e1bedf991189d0ef9b40dac9281bdf4739333a1
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS1 ADAMTS3 HDX ATP2B4	1.39e-04	180	65	4	d67d3196e6cc3dcd31023a4dc69310226181d583
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS1 ADAMTS3 HDX ATP2B4	1.39e-04	180	65	4	573308d43425d9fba20787abdb7f8efefc48efb5
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	SLC8A1 NBEAL1 FAT3 SDK1	1.48e-04	183	65	4	818fd886e0188091310825f9145fa53328f2c979
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS3 SHCBP1 MYO18B SDK1	1.48e-04	183	65	4	b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCell	COVID-19-B_cells-Plasma_cells\|COVID-19 / group, cell type (main and fine annotations)	FBH1 SHCBP1 TP73 SP140	1.48e-04	183	65	4	130c109f63a5e3c8f83cb96e32f4addf513b6415
ToppCell	COVID-19-B_cells\|COVID-19 / group, cell type (main and fine annotations)	FBH1 SHCBP1 TP73 SP140	1.48e-04	183	65	4	2c016bb59f131a0e821853b085289a3583f0a729
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC8A1 FAT3 TENM1 SDK1	1.51e-04	184	65	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC8A1 FAT3 TENM1 SDK1	1.51e-04	184	65	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC8A1 FAT3 TENM1 SDK1	1.51e-04	184	65	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS3 SHCBP1 MYO18B SDK1	1.54e-04	185	65	4	d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NPR1 FBN1 FAT3 TNKS1BP1	1.54e-04	185	65	4	a6874dd3030d04380cc3c01de1069461aad4ef45
ToppCell	mild-unassigned\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CSRNP2 NUP133 PFKL ADCY3	1.57e-04	186	65	4	5b2e1a58916f392fa1156bf9210df528775248ff
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	SLC8A1 CADPS FRMPD2 MYO18B	1.64e-04	188	65	4	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	SLC8A1 NBEAL1 FAT3 SDK1	1.64e-04	188	65	4	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	10x3'2.3-week_14-16-Mesenchymal_fibro-stroma-endosteal_fibroblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	LRIG3 FBN1 TENM1 SDK1	1.64e-04	188	65	4	0e2d1b21f0a7ee306e7dae16fc8c19d16a467883
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 ADAMTS3 FAT3 SDK1	1.67e-04	189	65	4	a153b83314cf52808f685296cff8c95af3f4983d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC8A1 MYO18B SDK1 ATP2B4	1.67e-04	189	65	4	127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC8A1 MYO18B SDK1 ATP2B4	1.67e-04	189	65	4	2cfb4d12f75678d1619f4743838a0e954bd57761
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	THBS1 FBN1 FAT3 SDK1	1.71e-04	190	65	4	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 NBEAL1 STARD9 ADCY3	1.74e-04	191	65	4	04c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	SLC8A1 FBN1 FAT3 ADCY3	1.74e-04	191	65	4	78c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CADPS IKZF1 CD163 SP140	1.74e-04	191	65	4	468b5149d1533f03521844d3cce8633d44eb6ed4
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	LRIG3 RB1CC1 NFAT5 SDK1	1.78e-04	192	65	4	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ASTN1 MYO18B SDK1 ADCY3	1.78e-04	192	65	4	bfab13793e54de2550ee171397f7ece0625cdb4a
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 ADAMTS3 FAT3 SDK1	1.78e-04	192	65	4	dcd924d6eb67d33ee9f5d3e8ab6e1d4283d6b708
ToppCell	LPS_only-Stromal_mesenchymal\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 FBN1 FAT3 SDK1	1.78e-04	192	65	4	162d8b5858d150ecbbd1c9bf2b19c6c9cd50a158
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ASTN1 MYO18B SDK1 ADCY3	1.78e-04	192	65	4	b54b0d5b88139905521c8d5d58332e89c08d589c
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 FBN1 FAT3 SDK1	1.78e-04	192	65	4	3d0cb19f037f604253d7d728689aeaa94251e92b
ToppCell	LPS-IL1RA-Stromal_mesenchymal\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 FBN1 FAT3 SDK1	1.78e-04	192	65	4	4e47a02007f562f29ba5910df64d32a0167d0bd1
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 ADAMTS3 FAT3 SDK1	1.78e-04	192	65	4	deeecd26972241846b4cb998edf0c7a87ff0c4df
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 ADAMTS3 FAT3 SDK1	1.81e-04	193	65	4	fb28717fadd06c3840636d25409ce80c9254bd34
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	THBS1 FBN1 ADAMTS3 SDK1	1.81e-04	193	65	4	261cafc167c86ab277be4ea7f08b0173e2dde26e
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 ADAMTS3 FAT3 SDK1	1.85e-04	194	65	4	60622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCell	LPS-antiTNF-Stromal_mesenchymal\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBS1 FBN1 FAT3 SDK1	1.85e-04	194	65	4	6e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC8A1 IKZF1 CD163 SP140	1.88e-04	195	65	4	ce8215d503cad3a9bc7d5d2be4adb57408015593
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS10 FBN1 DSC3 FAT3	1.88e-04	195	65	4	f5e91ce20a7ce528dc4c1a968c7bf096bf45c528
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC8A1 IKZF1 CD163 SP140	1.96e-04	197	65	4	c9b1f2ee7eb31a66af331c5aae29e1bbb5186f5a
ToppCell	control-Myeloid-Non-resident_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	THBS1 SLC8A1 WASHC4 CD163	1.96e-04	197	65	4	df2fe36cb96e2565a9d21c24cb4e451e8befd4be
ToppCell	TCGA-Skin-Metastatic-Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	SLC8A1 NBEAL1 PTGER2 CD163	2.00e-04	198	65	4	af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCell	COVID-19-lung-Fibroblast\|COVID-19 / Disease (COVID-19 only), tissue and cell type	THBS1 FBN1 FAT3 SDK1	2.00e-04	198	65	4	3ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCell	TCGA-Skin-Metastatic\|TCGA-Skin / Sample_Type by Project: Shred V9	SLC8A1 NBEAL1 PTGER2 CD163	2.00e-04	198	65	4	ad39cce004867f083f8da1954e0cf5a263815184
ToppCell	background-Hepatic_Stellate_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	THBS1 SLC8A1 FBN1 FAT3	2.00e-04	198	65	4	79f32f965aed6a10c5cb803173e3db7b32e07a91
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLC8A1 FAT3 TENM1 MYO18B	2.00e-04	198	65	4	d1827e3707b929e3a3562989a0c11537d344e164
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC8A1 WASHC4 CD163 SLC3A2	2.00e-04	198	65	4	885cbd3695b466a161cf318d35ebbdfcc0c19cec
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	SLC8A1 NBEAL1 PTGER2 CD163	2.00e-04	198	65	4	62cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Mesenchymal-Cilia-bearing_cell\|10w / Sample Type, Dataset, Time_group, and Cell type.	LRIG3 FBN1 FRMPD2 TP73	2.04e-04	199	65	4	2d8ab4aee300c7c4baf662940ce855da2b6d2cae
ToppCell	moderate-Myeloid-Non-resident_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	THBS1 PTGER2 CD163 SLC3A2	2.04e-04	199	65	4	3895e367a33ac0316f96a64c07574de99684f4b7
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 SLC8A1 ADAMTS3 NFAT5	2.04e-04	199	65	4	3cd6383c50ce342fe5c175e2e50784d634a90e80
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	THBS1 FBN1 ADAMTS3 SDK1	2.08e-04	200	65	4	9b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	THBS1 FBN1 FAT3 SDK1	2.08e-04	200	65	4	e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCell	Transverse-Dendritic_cell-cycling_DCs\|Transverse / Region, Cell class and subclass	SLC8A1 BRCA1 SHCBP1 CD163	2.08e-04	200	65	4	f588d8889f351c797963616a3575fa43efd46b9a
ToppCell	Parenchymal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	THBS1 FBN1 FAT3 SDK1	2.08e-04	200	65	4	cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCell	Skin-Fibroblasts\|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.	ADAMTS10 THBS1 FBN1 CADPS	2.08e-04	200	65	4	f777eadf571a1a6d246da87346a9cb9d511c2e81
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	THBS1 FBN1 FAT3 SDK1	2.08e-04	200	65	4	cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCell	Transverse-(5)_Dendritic_cell-(52)_cycling_DCs\|Transverse / shred on region, Cell_type, and subtype	SLC8A1 BRCA1 SHCBP1 CD163	2.08e-04	200	65	4	51e643d48b5e97a0e117b578a6ea7d429c6cdd1e
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	THBS1 FBN1 FAT3 SDK1	2.08e-04	200	65	4	311fab076f2ceb258e3970eb21e39344b894042a
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	THBS1 FBN1 FAT3 SDK1	2.08e-04	200	65	4	34f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Intermediate\|3m / Sample Type, Dataset, Time_group, and Cell type.	NBEAL1 ETFB FNIP1 PFKM	2.08e-04	200	65	4	cbd0b9188a94778ffa539912aeb2a4378f0ab88f
Computational	Neighborhood of TFDP2	KRT2 BRCA1 MLLT10 RB1CC1 NFAT5 ADCY3 SP140	3.66e-05	230	44	7	MORF_TFDP2
Computational	Neighborhood of ERCC4	KRT2 BRCA1 MAGEC1 MLLT10 RB1CC1 NFAT5 ADCY3	2.94e-04	321	44	7	MORF_ERCC4
Computational	Neighborhood of IL16	KRT2 BRCA1 MLLT10 RB1CC1 NFAT5 ADCY3	3.95e-04	239	44	6	MORF_IL16
Computational	Neighborhood of NF1	KRT2 BRCA1 NFAT5 ADCY3 SP140	6.15e-04	170	44	5	MORF_NF1
Computational	Neighborhood of BRCA1	KRT2 BRCA1 MLLT10 RB1CC1 NFAT5 ADCY3	6.55e-04	263	44	6	MORF_BRCA1
Computational	Neighborhood of PPP2R5B	KRT2 BRCA1 MLLT10 RB1CC1 ADCY3	6.66e-04	173	44	5	MORF_PPP2R5B
Computational	Neighborhood of MDM2	KRT2 BRCA1 MLLT10 RB1CC1 NFAT5 ADCY3	8.92e-04	279	44	6	MORF_MDM2
Computational	Neighborhood of BCL2L11	KRT2 BRCA1 MLLT10 RB1CC1 NFAT5	9.24e-04	186	44	5	MORF_BCL2L11
Computational	Neighborhood of BNIP1	KRT2 BRCA1 MLLT10 RB1CC1 ADCY3	1.02e-03	190	44	5	MORF_BNIP1
Computational	Neighborhood of CASP10	MLLT10 NFAT5 ADCY3 SP140	1.29e-03	117	44	4	MORF_CASP10
Computational	Neighborhood of MLLT10	KRT2 BRCA1 MLLT10 RB1CC1 NFAT5 ADCY3	1.34e-03	302	44	6	MORF_MLLT10
Computational	Neighborhood of ARL3	KRT2 BRCA1 MLLT10 RB1CC1 NFAT5 ADCY3	1.39e-03	304	44	6	MORF_ARL3
Computational	Neighborhood of ATF2	KRT2 BRCA1 ADAMTS3 MLLT10 RB1CC1 NFAT5	2.11e-03	330	44	6	MORF_ATF2
Disease	Weill-Marchesani syndrome	ADAMTS10 FBN1	1.30e-05	3	62	2	C0265313
Disease	Weill-Marchesani Syndrome, Autosomal Dominant	ADAMTS10 FBN1	1.30e-05	3	62	2	C1869115
Disease	Weill-Marchesani Syndrome, Autosomal Recessive	ADAMTS10 FBN1	1.30e-05	3	62	2	C1869114
Disease	Weill-Marchesani syndrome (implicated_via_orthology)	ADAMTS10 FBN1	1.30e-05	3	62	2	DOID:0050475 (implicated_via_orthology)
Disease	glycogen storage disease (implicated_via_orthology)	PFKL PFKM	2.60e-05	4	62	2	DOID:2747 (implicated_via_orthology)
Disease	Weill-Marchesani syndrome	ADAMTS10 FBN1	2.60e-05	4	62	2	cv:C0265313
Disease	Weill-Marchesani syndrome (is_implicated_in)	ADAMTS10 FBN1	2.60e-05	4	62	2	DOID:0050475 (is_implicated_in)
Disease	vital capacity	ADAMTS10 THBS1 SLC8A1 ADAMTS3 PCDHA1 MLLT10 MAPKBP1 MYO18B SDR16C5 NFAT5 ADCY3	4.75e-05	1236	62	11	EFO_0004312
Disease	body weight	ADAMTS10 ADAMTS3 NBEAL1 CADPS HDX FNIP1 PCDHA1 DCST2 MLLT10 SDR16C5 ATP2B4	5.69e-05	1261	62	11	EFO_0004338
Disease	grip strength measurement	SLC8A1 CADPS IKZF1 MLLT10 NFAT5 ADCY3	9.38e-05	350	62	6	EFO_0006941
Disease	waist-hip ratio	ADAMTS10 ARID4A CADPS DCST2 MLLT10 MAPKBP1 NFAT5 ATP2B4 ADCY3 TP73	2.22e-04	1226	62	10	EFO_0004343
Disease	comparative body size at age 10, self-reported	ADAMTS10 CADPS SANBR RB1CC1 SDR16C5 ADCY3	2.52e-04	420	62	6	EFO_0009819
Disease	non-lobar intracerebral hemorrhage	NBEAL1 MYO18B PMF1	3.21e-04	63	62	3	EFO_0010178
Disease	neuroimaging measurement	THBS1 CSRNP2 BRCA1 ADAMTS3 NBEAL1 CADPS FAT3 MLLT10 SDR16C5	3.75e-04	1069	62	9	EFO_0004346
Disease	Malignant neoplasm of breast	THBS1 BRCA1 DSC3 JMJD6 ZNF277 TENM1 NUP133 RB1CC1 TP73	3.88e-04	1074	62	9	C0006142
Disease	Diabetic Angiopathies	THBS1 ADCY3	5.11e-04	16	62	2	C0011875
Disease	Microangiopathy, Diabetic	THBS1 ADCY3	5.11e-04	16	62	2	C0025945
Disease	disease free survival	ICE1 SLC3A2	6.50e-04	18	62	2	EFO_0000409
Disease	diet measurement, HOMA-B	FAT3 NFAT5	7.26e-04	19	62	2	EFO_0004469, EFO_0008111
Disease	Mammary Carcinoma, Human	THBS1 BRCA1 DSC3 JMJD6 RB1CC1 TP73	8.16e-04	525	62	6	C4704874
Disease	Mammary Neoplasms, Human	THBS1 BRCA1 DSC3 JMJD6 RB1CC1 TP73	8.16e-04	525	62	6	C1257931
Disease	Mammary Neoplasms	THBS1 BRCA1 DSC3 JMJD6 RB1CC1 TP73	8.32e-04	527	62	6	C1458155
Disease	Headache, HbA1c measurement	NBEAL1 PFKM	8.89e-04	21	62	2	EFO_0004541, HP_0002315
Disease	disease of metabolism (implicated_via_orthology)	PFKL PFKM	8.89e-04	21	62	2	DOID:0014667 (implicated_via_orthology)
Disease	BREAST CANCER	BRCA1 RB1CC1	8.89e-04	21	62	2	114480
Disease	Breast Carcinoma	THBS1 BRCA1 DSC3 JMJD6 RB1CC1 TP73	9.25e-04	538	62	6	C0678222
Disease	Nephritis, Interstitial	THBS1 FAN1	1.16e-03	24	62	2	C0027707
Disease	stomach carcinoma (is_marker_for)	BRCA1 SLC3A2	1.16e-03	24	62	2	DOID:5517 (is_marker_for)
Disease	Endogenous Hyperinsulinism	FBN1 CD163	1.37e-03	26	62	2	C1257963
Disease	Exogenous Hyperinsulinism	FBN1 CD163	1.37e-03	26	62	2	C1257964
Disease	Compensatory Hyperinsulinemia	FBN1 CD163	1.37e-03	26	62	2	C1257965
Disease	Glycogen Storage Disease	PFKL PFKM	1.47e-03	27	62	2	C0017919
Disease	Malignant tumor of breast	BRCA1 RB1CC1	1.47e-03	27	62	2	cv:C0006142
Disease	Breast neoplasm	BRCA1 RB1CC1	1.47e-03	27	62	2	cv:C1458155
Disease	Familial cancer of breast	BRCA1 RB1CC1	1.47e-03	27	62	2	cv:C0346153
Disease	Hyperinsulinism	FBN1 CD163	1.59e-03	28	62	2	C0020459
Disease	Hyperglycemia, Postprandial	FBN1 CD163	1.82e-03	30	62	2	C1855520
Disease	cervical cancer (is_implicated_in)	BRCA1 TP73	1.82e-03	30	62	2	DOID:4362 (is_implicated_in)
Disease	Hyperglycemia	FBN1 CD163	1.82e-03	30	62	2	C0020456

Protein segments in the cluster

Peptide	Gene	Start	Entry
VSQERTSDCIGSEGM	ARID4A	881	P29374
RTDNEEGCGMVKTSQ	CSRNP2	511	Q9H175
GDTVNTASRMESNGE	NPR1	996	P16066
ANSMAESREGDFGCT	ATP2B4	11	P23634
ECMNGGEDFASQVTR	ASTN1	256	O14525
VGGMCERERSCSVNE	ADAMTS10	366	Q9H324
SGIDSCEMSDSGSQV	NBEAL1	1376	Q6ZS30
GNEETCKMAREAGAT	SDR16C5	76	Q8N3Y7
TDESAITQMCEVTGG	INTS6L	191	Q5JSJ4
DCFVVSEGANTMDIG	HACL1	391	Q9UJ83
DSGDNGRMVCSIQDD	PCDHB2	376	Q9Y5E7
RMQDTNVCGKEDFGD	RB1CC1	776	Q8TDY2
MVQSGGCSANDSREV	CADPS	196	Q9ULU8
EDNGCQMSDAVTVEV	NUP133	376	Q8WUM0
SMVGNGDTTSQDDCV	JMJD6	381	Q6NYC1
GNCLSIAMETGDAED	HDX	291	Q7Z353
DLTSEGCLSDEQGMS	MAGEC1	981	O60732
EESEGTGGQRSACAM	DNAAF2	496	Q9NVR5
TCEMSNTLGTERGNV	LRIG3	766	Q6UXM1
GEECRMSGDLSSNVT	KRT2	486	P35908
DNDFCGTDMTIGTDS	PFKL	166	P17858
DNDFCGTDMTIGTDS	PFKM	166	P08237
MGNASNDSQSEDCET	PTGER2	1	P43116
MAEASSANLGSGCEE	PMF1	1	Q6P1K2
TQSDEENGRACEMNG	IKZF1	61	Q13422
RMSCQDEGCGLESEQ	NFAT5	156	O94916
DRDSGANGQVTCSLM	PCDHA1	376	Q9Y5I3
RGNNEVVGGTDSSMD	TP73	36	O15350
MDSNLGEAASGCESE	BRCA1	1361	P38398
QMQSVCSDCNGEGEV	DNAJA2	181	O60884
VRTSADGQAGNEEMV	ADAMTS3	16	O15072
VGQDSCQDSEGDMIF	FBH1	81	Q8NFZ0
TGMSTVAKCDGERDD	ICE1	896	Q9Y2F5
GDDRVCSANGFMTQT	DSC3	741	Q14574
GMTSAGSDINECALD	FBN1	716	P35555
QCPSANDSMGDERTA	FRMPD2	1041	Q68DX3
GESDTQNMVSEEPCE	FNIP1	806	Q8TF40
EVVGVGDTCSFAQMD	ATG9A	511	Q7Z3C6
TSAGCGRFSQAMEVE	EPHA8	516	P29322
SDGNTDSCFNIDMET	FAT3	766	Q8TDW7
ASQNAEMIETGSDCV	SLC3A2	61	P08195
NATAGMETEGSCLEN	ADCY3	736	O60266
AASDGQVRMISCGAD	MAPKBP1	576	O60336
QDEGDMENTVSCSTP	DCST2	606	Q5T1A1
DAGVTCSDGSNLEMR	CD163	146	Q86VB7
SCEIVSEGGNDSRMA	SDK1	646	Q7Z5N4
SDLDSGDNGRVMCSI	PCDHB3	371	Q9Y5E6
DSMEDEDAACGGQGQ	FAN1	556	Q9Y2M0
AIDDDCNQTGQMTAG	ETFB	126	P38117
IEIMDDCSTNCNGNG	TENM1	526	Q9UKZ4
MSFRQGACVVTGSED	WDR13	416	Q9H1Z4
CNSDSEQENISMVEG	SHCBP1	271	Q8NEM2
RDSEAGAMEVNSIGN	STARD9	2126	Q9P2P6
ESENCTTHNGGEMTE	SANBR	126	Q6NSI8
RPEEQMESDNCSGGD	SQSTM1	321	Q13501
DEQGRESKAATGACM	MLLT10	141	P55197
QRDTDMDGVGDQCDN	THBS1	821	P07996
ASRCGIGQEEMEASS	TNKS1BP1	791	Q9C0C2
VDCGSSGRKEMDNVS	MYO18B	2101	Q8IUG5
ARMQEDRDGSCSTVG	ZNF277	11	Q9NRM2
EGATDASMVEGDCQI	WASHC4	121	Q2M389
SATGETEGGDICMEE	ZNF236	1081	Q9UL36
RTESDQACGTMDTVD	SP140	471	Q13342
MTAVSSNRNPEDDGC	nan	1	Q8N7P7
SQGESAEGMSQRCEE	ZNF7	186	P17097
ETEMEGEGNETGECT	SLC8A1	36	P32418