Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	L-leucine binding	UBR1 UBR2 SESN3	4.87e-06	7	105	3	GO:0070728
GeneOntologyMolecularFunction	CTP synthase activity	CTPS2 CTPS1	2.74e-05	2	105	2	GO:0003883
GeneOntologyMolecularFunction	amino acid binding	UBR1 UBR2 SESN3 MTR GRIN3B	4.13e-05	73	105	5	GO:0016597
GeneOntologyMolecularFunction	Wnt receptor activity	FZD8 PKD1 LRP6	9.11e-05	17	105	3	GO:0042813
GeneOntologyMolecularFunction	IgG receptor activity	FCGR2C FCGR2B	5.65e-04	7	105	2	GO:0019770
GeneOntologyBiologicalProcess	'de novo' CTP biosynthetic process	CTPS2 CTPS1	2.57e-05	2	105	2	GO:0044210
GeneOntologyBiologicalProcess	cellular response to L-leucine	UBR1 UBR2 SESN3	3.53e-05	13	105	3	GO:0071233
GeneOntologyBiologicalProcess	alpha-amino acid metabolic process	HGD GAMT DDO ARG1 CTPS2 MTR CTPS1 ALDH6A1	4.34e-05	251	105	8	GO:1901605
GeneOntologyBiologicalProcess	response to L-leucine	UBR1 UBR2 SESN3	6.84e-05	16	105	3	GO:0043201
GeneOntologyBiologicalProcess	non-proteinogenic amino acid metabolic process	GAMT DDO ARG1 MTR ALDH6A1	8.24e-05	87	105	5	GO:0170041
GeneOntologyBiologicalProcess	L-amino acid metabolic process	HGD GAMT DDO ARG1 CTPS2 MTR CTPS1	9.46e-05	208	105	7	GO:0170033
GeneOntologyBiologicalProcess	ubiquitin-dependent protein catabolic process via the N-end rule pathway	UBR1 UBR2	1.53e-04	4	105	2	GO:0071596
GeneOntologyBiologicalProcess	fast-twitch skeletal muscle fiber contraction	SYNM ACTN3	1.53e-04	4	105	2	GO:0031443
GeneOntologyBiologicalProcess	pyrimidine nucleobase metabolic process	CTPS2 CTPS1 ALDH6A1	1.84e-04	22	105	3	GO:0006206
GeneOntologyCellularComponent	cytoophidium	CTPS2 CTPS1	7.19e-05	3	103	2	GO:0097268
GeneOntologyCellularComponent	Wnt-Frizzled-LRP5/6 complex	FZD8 LRP6	2.38e-04	5	103	2	GO:1990851
Domain	ClpS_core	UBR1 UBR2	2.95e-05	2	102	2	IPR003769
Domain	ClpS	UBR1 UBR2	2.95e-05	2	102	2	PF02617
Domain	CTP_synthase_N	CTPS2 CTPS1	2.95e-05	2	102	2	IPR017456
Domain	GATase1_CTP_Synthase	CTPS2 CTPS1	2.95e-05	2	102	2	IPR033828
Domain	CTP_synthase	CTPS2 CTPS1	2.95e-05	2	102	2	IPR004468
Domain	CTP_synth_N	CTPS2 CTPS1	2.95e-05	2	102	2	PF06418
Domain	Ribosomal_L7/12_C/ClpS-like	UBR1 UBR2	8.83e-05	3	102	2	IPR014719
Domain	-	UBR1 UBR2	8.83e-05	3	102	2	3.30.1390.10
Domain	SCAN	SCAND2P ZSCAN32 ZKSCAN4 ZNF445	2.48e-04	56	102	4	SM00431
Domain	SCAN_BOX	SCAND2P ZSCAN32 ZKSCAN4 ZNF445	2.84e-04	58	102	4	PS50804
Domain	SCAN	SCAND2P ZSCAN32 ZKSCAN4 ZNF445	2.84e-04	58	102	4	PF02023
Domain	SCAN_dom	SCAND2P ZSCAN32 ZKSCAN4 ZNF445	2.84e-04	58	102	4	IPR003309
Domain	GATase	CTPS2 CTPS1	2.92e-04	5	102	2	PF00117
Domain	GATASE	CTPS2 CTPS1	4.37e-04	6	102	2	IPR017926
Domain	GATASE_TYPE_1	CTPS2 CTPS1	4.37e-04	6	102	2	PS51273
Domain	ZF_UBR	UBR1 UBR2	6.09e-04	7	102	2	PS51157
Domain	zf-UBR	UBR1 UBR2	6.09e-04	7	102	2	PF02207
Domain	Znf_UBR	UBR1 UBR2	6.09e-04	7	102	2	IPR003126
Domain	ZnF_UBR1	UBR1 UBR2	6.09e-04	7	102	2	SM00396
Domain	-	CTPS2 CTPS1	1.29e-03	10	102	2	3.40.50.880
Domain	Class_I_gatase-like	CTPS2 CTPS1	1.88e-03	12	102	2	IPR029062
Domain	Retrov_capsid_C	ZSCAN32 ZKSCAN4 ZNF445	4.12e-03	59	102	3	IPR008916
Domain	FRI	FZD8 COL18A1	5.26e-03	20	102	2	SM00063
Domain	-	FZD8 COL18A1	5.80e-03	21	102	2	1.10.2000.10
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	RTEL1 SYNE1 MED13L ZNF608 RAB3GAP2 HELZ2 DOP1B PCNT	4.74e-07	225	106	8	12168954
Pubmed	Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.	DCAF1 UBR1 UBR2	2.28e-06	9	106	3	17855541
Pubmed	Bound Waters Mediate Binding of Diverse Substrates to a Ubiquitin Ligase.	UBR1 UBR2	9.20e-06	2	106	2	28392261
Pubmed	Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.	FCGR2C FCGR2B	9.20e-06	2	106	2	2531080
Pubmed	Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway.	UBR1 UBR2	9.20e-06	2	106	2	20298436
Pubmed	Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.	UBR1 UBR2	9.20e-06	2	106	2	16606826
Pubmed	Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome).	UBR1 UBR2	9.20e-06	2	106	2	16311597
Pubmed	Regulation of protein catabolism by muscle-specific and cytokine-inducible ubiquitin ligase E3alpha-II during cancer cachexia.	UBR1 UBR2	9.20e-06	2	106	2	15548684
Pubmed	Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene.	FCGR2C FCGR2B	9.20e-06	2	106	2	9516136
Pubmed	Modulation of GPR133 (ADGRD1) signaling by its intracellular interaction partner extended synaptotagmin 1.	SYT1 ADGRD1	9.20e-06	2	106	2	38758649
Pubmed	Structural basis of substrate recognition and specificity in the N-end rule pathway.	UBR1 UBR2	9.20e-06	2	106	2	20835242
Pubmed	Regulation of human cytidine triphosphate synthetase 2 by phosphorylation.	CTPS2 CTPS1	9.20e-06	2	106	2	20739275
Pubmed	Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A.	CTPS2 CTPS1	2.76e-05	3	106	2	16179339
Pubmed	RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.	UBR1 UBR2	2.76e-05	3	106	2	15317757
Pubmed	Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus.	FCGR2C FCGR2B	2.76e-05	3	106	2	23261299
Pubmed	Polycystin-1 interacts with inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling with implications for polycystic kidney disease.	ITPR1 PKD1	2.76e-05	3	106	2	19854836
Pubmed	Identification of Ubr1 as an amino acid sensor of steatosis in liver and muscle.	UBR1 UBR2	2.76e-05	3	106	2	37057345
Pubmed	Functional Fcgamma receptor polymorphisms are associated with human allergy.	FCGR2C FCGR2B	2.76e-05	3	106	2	24586589
Pubmed	Insertional mutation of the motor endplate disease (med) locus on mouse chromosome 15.	SYT1 CNTN1	2.76e-05	3	106	2	7601440
Pubmed	Nonallelic homologous recombination of the FCGR2/3 locus results in copy number variation and novel chimeric FCGR2 genes with aberrant functional expression.	FCGR2C FCGR2B	2.76e-05	3	106	2	26133275
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DCAF1 UBR2 SYNE1 MED13L RAB3GAP2 CAMSAP2 DOP1B PCNT	3.65e-05	407	106	8	12693553
Pubmed	Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway.	UBR1 UBR2	5.50e-05	4	106	2	14585983
Pubmed	IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis.	FZD8 LRP6	5.50e-05	4	106	2	18528331
Pubmed	Inhibition of Wnt/β-catenin signaling by a soluble collagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8.	FZD8 COL18A1	5.50e-05	4	106	2	22303445
Pubmed	A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.	UBR1 UBR2	5.50e-05	4	106	2	16055722
Pubmed	The substrate recognition domains of the N-end rule pathway.	UBR1 UBR2	5.50e-05	4	106	2	19008229
Pubmed	The ATF3 Transcription Factor Is a Short-Lived Substrate of the Arg/N-Degron Pathway.	UBR1 UBR2	5.50e-05	4	106	2	32692156
Pubmed	Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins.	FZD8 LRP6	5.50e-05	4	106	2	15064719
Pubmed	An essential role of N-terminal arginylation in cardiovascular development.	UBR1 UBR2	5.50e-05	4	106	2	12098698
Pubmed	SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.	FZD8 LRP6	5.50e-05	4	106	2	15908424
Pubmed	Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway.	UBR1 UBR2	5.50e-05	4	106	2	11689692
Pubmed	The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments.	UBR1 UBR2	5.50e-05	4	106	2	22670058
Pubmed	Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.	FZD8 LRP6	9.15e-05	5	106	2	11448771
Pubmed	Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation.	PKD1 PCNT	9.15e-05	5	106	2	21041232
Pubmed	A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus.	PKD1 PCNT	9.15e-05	5	106	2	19774080
Pubmed	structural Studies of Wnts and identification of an LRP6 binding site.	FZD8 LRP6	9.15e-05	5	106	2	23791946
Pubmed	SNPs of Fc-gamma receptor genes and chronic periodontitis.	FCGR2C FCGR2B	9.15e-05	5	106	2	20439936
Pubmed	Copy number, linkage disequilibrium and disease association in the FCGR locus.	FCGR2C FCGR2B	9.15e-05	5	106	2	20508037
Pubmed	Knockdown of interleukin-10 induces the redistribution of sigma1-receptor and increases the glutamate-dependent NADPH-oxidase activity in mouse brain neurons.	SIGMAR1 ITPR1	9.15e-05	5	106	2	26453192
Pubmed	LDL-receptor-related proteins in Wnt signal transduction.	FZD8 LRP6	9.15e-05	5	106	2	11029007
Pubmed	Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B.	FCGR2C FCGR2B	9.15e-05	5	106	2	19309690
Pubmed	Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice.	CTPS2 CTPS1	1.37e-04	6	106	2	38438357
Pubmed	Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway.	UBR1 UBR2	1.37e-04	6	106	2	10805755
Pubmed	Five enzymes of the Arg/N-degron pathway form a targeting complex: The concept of superchanneling.	UBR1 UBR2	1.37e-04	6	106	2	32366662
Pubmed	Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development.	FZD8 LRP6	1.37e-04	6	106	2	25871009
Pubmed	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	HGD MYO7A DDO CPQ PKD1	1.84e-04	171	106	5	20201926
Pubmed	Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear.	MYO7A PCNT	1.91e-04	7	106	2	17376975
Pubmed	Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.	UBR1 UBR2	1.91e-04	7	106	2	21816346
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	PLB1 DGKZ TBC1D17 ZNF512B FZD8 COL18A1 GRIN3B CTPS1 CCDC9 ZNF445	2.34e-04	832	106	10	36724073
Pubmed	Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.	FZD8 LRP6	2.55e-04	8	106	2	20093360
Pubmed	Genetic control of lipid transport in mice. II. Genes controlling structure of high density lipoproteins.	ME1 FCGR2B	2.55e-04	8	106	2	6403543
Pubmed	Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair.	FZD8 LRP6	2.55e-04	8	106	2	15035989
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	DCAF1 SYNE1 SACS ZBED1	2.65e-04	101	106	4	9872452
Pubmed	LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.	FZD8 LRP6	3.27e-04	9	106	2	11357136
Pubmed	A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum.	ADAMTS3 ITPR1	3.27e-04	9	106	2	31491533
Pubmed	Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression.	FZD8 LRP6	3.27e-04	9	106	2	16543246
Pubmed	Vpr-induced DNA double-strand breaks: molecular mechanism and biological relevance.	DCAF1 RAD17	3.27e-04	9	106	2	19275579
Pubmed	CTPS and IMPDH form cytoophidia in developmental thymocytes.	CTPS2 CTPS1	4.08e-04	10	106	2	34022203
Pubmed	Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin.	FZD8 LRP6	4.08e-04	10	106	2	15143170
Pubmed	Interstitial microRNA miR-214 attenuates inflammation and polycystic kidney disease progression.	ARG1 PKD1	4.08e-04	10	106	2	32182218
Pubmed	Postnatal refinement of auditory hair cell planar polarity deficits occurs in the absence of Vangl2.	MYO7A PCNT	4.08e-04	10	106	2	23986237
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	MYO7A BCORL1 EXOC3L4 PKD1 PCIF1 CPSF1 CTPS1 FBXO34 DOP1B	4.29e-04	736	106	9	29676528
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ZNF487 DGKZ ITPR1 COL18A1 TMEM98 EXOC3L4 SYT1 HSD3B2 RAD17 PCNT ZNF445	4.80e-04	1084	106	11	11544199
Pubmed	Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.	MYO7A TMEM98 DOP1B	4.86e-04	50	106	3	24721909
Pubmed	Neuronal cell adhesion molecule (NrCAM) is expressed by sensory cells in the cochlea and is necessary for proper cochlear innervation and sensory domain patterning during development.	MYO7A SYT1	4.97e-04	11	106	2	29536590
Pubmed	Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.	THOC1 SYNE1	4.97e-04	11	106	2	20351715
Pubmed	ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.	FZD8 LRP6	4.97e-04	11	106	2	22575959
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	GAMT SYNM SYNE1 SESN3 MED13L USP9Y ZNF512B SACS PKD1 HECTD1 DOP1B PCNT	5.53e-04	1285	106	12	35914814
Pubmed	HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.	UBR1 UBR2	5.95e-04	12	106	2	17360488
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DCAF1 SYNM SYNE1 TBC1D17 ITPR1 ZNF512B COL18A1 NEO1 SACS CASKIN2 RAB3GAP2 MTR PCNT	5.99e-04	1487	106	13	33957083
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	UBR2 SEPTIN5 RTEL1 SIGMAR1 ZNF236 COL18A1 EXD3 ZNF608 TMEM98 CYB5D1 HECTD1 ADGRD1 PCNT	6.06e-04	1489	106	13	28611215
Pubmed	The DNA sequence and analysis of human chromosome 6.	UBR2 ZSCAN12 C6orf62 SYNE1 DDO ME1 ARG1 ZKSCAN4	6.50e-04	622	106	8	14574404
Pubmed	Genetic ablation of androgen receptor signaling in fetal Leydig cell lineage affects Leydig cell functions in adult testis.	THBS2 HSD3B2	8.18e-04	14	106	2	25713029
Pubmed	Glycine prevents metabolic steatohepatitis in diabetic KK-Ay mice through modulation of hepatic innate immunity.	ARG1 CIITA	8.18e-04	14	106	2	27659424
Pubmed	Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.	SACS SYT1	8.18e-04	14	106	2	15082773
Pubmed	A genome-wide association study identifies protein quantitative trait loci (pQTLs).	FZD8 SACS CNTN1	8.71e-04	61	106	3	18464913
Pubmed	UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.	DCAF1 UBR1 UBR2	9.13e-04	62	106	3	18775313
Pubmed	Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy.	ACTN3 MTR	9.41e-04	15	106	2	11440986
Pubmed	Phenotypic analysis of mice completely lacking netrin 1.	NEO1 CNTN1	9.41e-04	15	106	2	26395479
Pubmed	Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.	UBR1 UBR2 OMA1 MRM3 GFM1 HECTD1 DOP1B	1.04e-03	515	106	7	31617661
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	SEPTIN5 SYNE1 DGKZ SYT1 CNTN1	1.05e-03	251	106	5	27507650
Pubmed	Localization of septin proteins in the mouse cochlea.	SEPTIN5 MYO7A	1.07e-03	16	106	2	22575789
Pubmed	ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family.	ADAMTS3 FCGR2B	1.21e-03	17	106	2	10464288
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	DCAF1 RTEL1 SYNE1 ADGRD1	1.23e-03	152	106	4	34299191
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	ASPHD1 SYNE1 SACS TMEM98 PKD1 SYT1 TMCO3 CNTN1	1.35e-03	697	106	8	28298427
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	RTEL1 MED13L ZNF730	1.35e-03	71	106	3	33541421
Pubmed	Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.	MYO7A ITPR1 CNTN1	1.41e-03	72	106	3	25917818
Pubmed	Bardet-Biedl Syndrome proteins regulate cilia disassembly during tissue maturation.	MYO7A PCNT	1.52e-03	19	106	2	30446775
Pubmed	Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.	FZD8 LRP6	1.52e-03	19	106	2	21623369
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	DCAF1 SIGMAR1 MRM3 HECTD1 PCNT	1.84e-03	285	106	5	32838362
Pubmed	A series of recombinant inbred strains between the BALB/cHeA and STS/A mouse strains.	ME1 FCGR2B	1.86e-03	21	106	2	4042679
Pubmed	Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection.	DCAF1 UBR2	1.86e-03	21	106	2	22190037
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	OMA1 SYNM SYNE1 TBC1D17 ITPR1 ZNF512B MRM3 RAB3GAP2 MTR CPSF1 GFM1 PCNT	2.03e-03	1496	106	12	32877691
Pubmed	DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.	SYNE1 PCNT	2.04e-03	22	106	2	12812986
Pubmed	Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.	FZD8 LRP6	2.04e-03	22	106	2	17064353
Pubmed	EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia.	MYO7A PCNT	2.04e-03	22	106	2	34001891
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MYO7A MED13L ZNF236 TBC1D17 PKD1 HELZ2 CPSF1 HECTD1 LTBP4 PCNT	2.04e-03	1105	106	10	35748872
Pubmed	GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.	SEPTIN5 CPQ	2.23e-03	23	106	2	23725790
Pubmed	A role for Wnt/beta-catenin signaling in lens epithelial differentiation.	FZD8 LRP6	2.64e-03	25	106	2	12812787
Pubmed	Hereditary Ataxia Overview	SYNE1 ITPR1 SACS	2.84e-03	92	106	3	20301317
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR1 UBR2	2.56e-04	7	64	2	785
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7A FCGR2B EXOC3L4 CD38 C1QTNF1 LTBP4	6.14e-06	191	105	6	1924af7d8b0a0b892e480a9fd6d874941b0c0b5d
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SEPTIN5 SYNE1 ITPR1 SYT1 C1QTNF1 LTBP4	6.14e-06	191	105	6	7853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7A FCGR2B EXOC3L4 CD38 C1QTNF1 LTBP4	6.14e-06	191	105	6	88f91e57a1409bdeb91e9bf47510a6fb998a1bf5
ToppCell	renal_papilla_nuclei-Adult_normal_reference\|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	USP9Y ME1 ITPR1 ZNF608 MTR SYT1	6.33e-06	192	105	6	6c106b91e46eabbe686a52a65a9c94ad9cbe9390
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS3 THBS2 SYT1 LTBP4 ADGRD1 CNTN1	6.72e-06	194	105	6	c49f72441b3557e2c3a9c4239e68c0cf0652814b
ToppCell	368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	GAMT MYO7A SYNE1 FCGR2B CCDC9 ZNF445	6.72e-06	194	105	6	58046894446cb250814252a23f60fdd59c114d77
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SEPTIN5 SYNM SYNE1 ITPR1 COL18A1 C1QTNF1	7.99e-06	200	105	6	a3a1e35934d676c39f917652e50c502cb2f613c1
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SEPTIN5 SYNM SYNE1 ITPR1 COL18A1 C1QTNF1	7.99e-06	200	105	6	c06426f877919bdd267ea2fd7e7973c6619832ae
ToppCell	COVID-19-Heart-CM_5_(RYR2-)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SYNM ACTN3 MRM3 ASB5 PCNT	2.34e-05	144	105	5	f92e03dd784e31a9e5dbd4f4c3a6517ea19210cf
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PLB1 DGKZ EXD3 PIK3R6 TMEM98	3.65e-05	158	105	5	74aa4f75307575ac3b2b1aa9f727753692f88742
ToppCell	lung-Type_I_Pneumocytes\|lung / shred on tissue and cell subclass	HGD STK17A MOB3B LRP6	4.26e-05	82	105	4	6023212a51f8b3e05e6c3dcf4e8fbf53ba696fb2
ToppCell	facs-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGD GAMT DDO ME1 ALDH6A1	5.02e-05	169	105	5	ee27bcfe3f9a295ec5fb0a375d77d1050e5cbaad
ToppCell	facs-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGD GAMT DDO ME1 ALDH6A1	5.02e-05	169	105	5	922086f218135b734b7d370b871923e50141edce
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FCGR2B CIITA SACS SYT1 CNTN1	5.77e-05	174	105	5	ebe6ce173ad12d4a2afa39f8d6185c0e4f97fb1e
ToppCell	IPF-Epithelial-Mesothelial\|IPF / Disease state, Lineage and Cell class	ADAMTS3 FERMT1 THBS2 C1QTNF1 ADGRD1	6.77e-05	180	105	5	1fa54bf4dba72866b2295639d991af639341bc08
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7A FCGR2B EXOC3L4 C1QTNF1 LTBP4	7.14e-05	182	105	5	000ff26c51c6a1ea8770c02722523e55be83b46f
ToppCell	facs-Liver-Liver_non-hepato/SCs_st\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7A FCGR2B EXOC3L4 C1QTNF1 LTBP4	7.14e-05	182	105	5	b906e6e584ecbe92d3030bbdc4426f244fbe0045
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SEPTIN5 COL18A1 LRP6 C1QTNF1 CNTN1	7.51e-05	184	105	5	102b6f621a5b551e622f97b12d787c080b052a72
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3R6 FCGR2B ASB5 C1QTNF1 LTBP4	7.71e-05	185	105	5	742350093d90f96735dc73e3360cdd749bae63fd
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(RGS5+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ASPHD1 ADAMTS3 COL18A1 NEO1 TMEM98	7.71e-05	185	105	5	11fbea1eb1d9a3e4480d0d2b0f7b02e2866b8142
ToppCell	COPD-Epithelial-Mesothelial\|COPD / Disease state, Lineage and Cell class	ADAMTS3 FERMT1 THBS2 TMEM98 C1QTNF1	8.53e-05	189	105	5	79bb2593ad5d17f94b17972884241f03a0f43770
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ITPR1 ZNF608 FCGR2B CIITA MOB3B	8.74e-05	190	105	5	112706d64ee73b55dcf76f33ca064ab1fc6ce87f
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PLB1 MYO7A ME1 FCGR2B CIITA	8.74e-05	190	105	5	f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ZNF512B THBS2 CPQ C1QTNF1 LTBP4	8.96e-05	191	105	5	9bbafdf316c1fa3a9f1ee30d41dd7158b5c97279
ToppCell	critical-Lymphoid-B_cell\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	STK17A SESN3 FCGR2B CIITA SYT1	8.96e-05	191	105	5	0716cfaeb11d9c90c18fa8f9d50c9c6fb5182848
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	THBS2 CPQ C1QTNF1 LTBP4 ADGRD1	9.18e-05	192	105	5	fc940f91ff8e051631dbf25e6e8d73cf8337eccb
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	THBS2 CPQ C1QTNF1 LTBP4 ADGRD1	9.18e-05	192	105	5	7a2e79490e4f7058bb76b46c45b5df9f729e3146
ToppCell	343B-Lymphocytic-ILC-ILC-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MYO7A DPP3 ZSCAN32 DSTYK RAB3GAP2	9.18e-05	192	105	5	445985fe1bcd33e4f0a1704b27988fbfc9334538
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS2 CPQ C1QTNF1 LTBP4 ADGRD1	9.41e-05	193	105	5	92048d2e9e43513e6185e09553be3ee47d7e5207
ToppCell	facs-Lung-nan-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEO1 CPQ C1QTNF1 LTBP4 ADGRD1	9.41e-05	193	105	5	d9c20a092b507c43fcf7ccb04073fecd27d1749c
ToppCell	LA-14._Fibroblast_III\|LA / Chamber and Cluster_Paper	COL18A1 THBS2 C1QTNF1 CYB5D1 ADGRD1	9.41e-05	193	105	5	7426c291bac59e539c427bcaae18abc7d397d44e
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS2 CPQ C1QTNF1 LTBP4 ADGRD1	9.41e-05	193	105	5	ac088c8f27b5b1888610e461ff45870ca60da886
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7A FCGR2B EXOC3L4 C1QTNF1 LTBP4	9.87e-05	195	105	5	12ba6d95e42d06b1991b011043c0e3370a7b4131
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS3 THBS2 LTBP4 ADGRD1 CNTN1	9.87e-05	195	105	5	3c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCell	343B-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	GAMT MYO7A SYNE1 FCGR2B SYT1	9.87e-05	195	105	5	67b05a0cd2ca9924eca81a92cc6330eecb9d963c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PLB1 ME1 FCGR2B CIITA CD38	9.87e-05	195	105	5	34a9462f4e843f3065cc58c17ad71c1b5b836ae1
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7A FCGR2B CD38 C1QTNF1 LTBP4	1.01e-04	196	105	5	81900dcc9451ff6606ec940c16b559d73247590e
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SYNE1 SESN3 NEO1 TMEM98 LTBP4	1.01e-04	196	105	5	b04ca69b0ed44e09c989b575f747e1e819cd8008
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SYNE1 SESN3 NEO1 TMEM98 LTBP4	1.01e-04	196	105	5	a31e227de2dc077b81881295b012d22fedbd65ed
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	THBS2 SYT1 LTBP4 ADGRD1 CNTN1	1.04e-04	197	105	5	6d027119a5f7ca2aac1b10837e43f9a2bb54db85
ToppCell	distal-Hematologic-IGSF21+_Dendritic-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PLB1 MYO7A ME1 FCGR2C FCGR2B	1.04e-04	197	105	5	e77c91f5a1f5a292eda41abf3b1e31180f2c61e1
ToppCell	distal-3-Hematologic-IGSF21+_Dendritic\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PLB1 MYO7A ME1 FCGR2C FCGR2B	1.04e-04	197	105	5	52e9dc35dd8cc2605fa4894bb16bb5c6086faa76
ToppCell	proximal-3-Hematologic-Myeloid_Dendritic_Type_2\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CHRNA6 PLB1 FCGR2C FCGR2B CIITA	1.06e-04	198	105	5	2e07e62ed230763a6859a8ce19429b5ca8b365a6
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SYNE1 ITPR1 PKD1 SYT1 CNTN1	1.06e-04	198	105	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	proximal-Hematologic-Myeloid_Dendritic_Type_2\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CHRNA6 PLB1 FCGR2C FCGR2B CIITA	1.06e-04	198	105	5	3b0143efc33486c1e340ca57981c83cf7e2cad29
ToppCell	distal-Hematologic-Myeloid_Dendritic_Type_2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CHRNA6 PLB1 FCGR2C FCGR2B CIITA	1.06e-04	198	105	5	f44eb16695ea52e3f99073f5976590069b1d9c5a
ToppCell	normal_Lung-Myeloid_cells-mo-Mac\|Myeloid_cells / Location, Cell class and cell subclass	GAMT MYO7A SESN3 ME1 FCGR2B	1.06e-04	198	105	5	fbd72ebaba73cc30e79dc8a8c3d46b6f863c1494
ToppCell	Tracheal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SYNM ITPR1 ASB5 C1QTNF1 CNTN1	1.06e-04	198	105	5	1e1ea54f0c234f3b6d29064c4881d8a0c0949a75
ToppCell	proximal-Hematologic-Myeloid_Dendritic_Type_2-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CHRNA6 PLB1 FCGR2C FCGR2B CIITA	1.06e-04	198	105	5	f254287e13328a8f3b14bf4e44736041ad35593e
ToppCell	Bronchial_Biopsy\|World / Tissue, Lineage and Cell class of Lung Cells from 10X	GAMT FERMT1 SESN3 ZNF608 LTBP4	1.06e-04	198	105	5	f5b7013045b61fc56894f80092f799770dde1c8f
ToppCell	(1)_Osterolineage_cells-(11)_OLC-2\|(1)_Osterolineage_cells / Cell class and subclass of bone marrow stroma cells in homeostatis	SYNM SYNE1 THBS2 PKD1 LTBP4	1.06e-04	198	105	5	9f9dcf23ffb333105263132d87b90095642294cf
ToppCell	Transverse-(2)_B_cell-(23)_Follicular_B_cell\|Transverse / shred on region, Cell_type, and subtype	STK17A CIITA MOB3B HSD3B2 ADGRD1	1.09e-04	199	105	5	9c49e114e17cdefc2651050fc3251e59ea251289
ToppCell	Transverse-B_cell-Follicular_B_cell\|Transverse / Region, Cell class and subclass	STK17A CIITA MOB3B HSD3B2 ADGRD1	1.09e-04	199	105	5	1fa6e464fc929e721738e175389b85018c5e975f
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SEPTIN5 SYNE1 ITPR1 SYT1 ADGRD1	1.11e-04	200	105	5	f599e4b051ac3dad11ad437e98dc8ea6754cca53
ToppCell	Parenchymal-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SYNM ZNF512B COL18A1 LTBP4 ZNF445	1.11e-04	200	105	5	36de49593cf6ff1c9229fcceb150c1d68658a360
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_2\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CHRNA6 PLB1 PIK3R6 FCGR2B CIITA	1.11e-04	200	105	5	f0e7c2f07a7065511bf0b6521ce2e74e04e48544
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SEPTIN5 COL18A1 LRP6 C1QTNF1 CNTN1	1.11e-04	200	105	5	cf883ba5dbe6350b93142d625a52b25ff2a8bb63
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SYNM COL18A1 SACS ASB5 C1QTNF1	1.11e-04	200	105	5	a66449b22b39dd6987fc2c3ed160d24564234ced
ToppCell	Control_saline-Mesenchymal_myocytic\|Control_saline / Treatment groups by lineage, cell group, cell type	SEPTIN5 SYNE1 SYT1 C1QTNF1 ADGRD1	1.11e-04	200	105	5	5ed4261157cd51109b314818133ac3a0d34ee5fa
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial-Astrocyte\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	ZNF487 FZD8 HELZ2 MSS51 TMEM220	1.11e-04	200	105	5	b9bd6c4381c92bfc1bfff9aa778a62a41d08f1ef
ToppCell	Sigmoid-T_cell-Tfh\|T_cell / Region, Cell class and subclass	PLB1 ZNF613 COL18A1 HELZ2 ZKSCAN4	1.11e-04	200	105	5	dd7dcf25520f065bf0d33d589f3c176f63875dc9
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-NK_CD56bright\|ICU-NoSEP / Disease, condition lineage and cell class	STK17A ZNF236 CTPS2 CD38 TMEM220	1.11e-04	200	105	5	c2df917900872453ea17a39928e39d071a6d3339
ToppCell	LPS_IL1RA-Mesenchymal_myocytic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SEPTIN5 SYNE1 ITPR1 SYT1 C1QTNF1	1.11e-04	200	105	5	77631c471cc5d453a749784f838cfa6408caf09b
Drug	Pancuronium bromide [15500-66-0]; Up 200; 5.4uM; MCF7; HT_HG-U133A	DCAF1 ACTN3 ZNF236 ITPR1 FZD8 RAB3GAP2 CPSF1 ALDH6A1 LTBP4	3.76e-07	198	106	9	4393_UP
Drug	Methacycline hydrochloride [3963-95-9]; Down 200; 8.4uM; HL60; HT_HG-U133A	DCAF1 SYNE1 TBC1D17 ZNF512B DSTYK RAB3GAP2 LRP6 CAMSAP2	3.69e-06	195	106	8	2901_DN
Disease	Amino Acid Metabolism, Inherited Disorders	GAMT ARG1 ALDH6A1	1.12e-05	13	102	3	C0750905
Disease	Amino Acid Metabolism, Inborn Errors	GAMT ARG1 ALDH6A1	1.12e-05	13	102	3	C0002514
Disease	plexin-B2 measurement	FCGR2C FCGR2B	4.19e-04	9	102	2	EFO_0021867
Disease	malaria (implicated_via_orthology)	FCGR2C FCGR2B	4.19e-04	9	102	2	DOID:12365 (implicated_via_orthology)
Disease	silicosis (biomarker_via_orthology)	RTEL1 ARG1	1.05e-03	14	102	2	DOID:10325 (biomarker_via_orthology)
Disease	congenital myasthenic syndrome (implicated_via_orthology)	CHRNA6 SYT1	1.38e-03	16	102	2	DOID:3635 (implicated_via_orthology)
Disease	low affinity immunoglobulin gamma Fc region receptor II-a measurement	FCGR2C FCGR2B	1.56e-03	17	102	2	EFO_0021969
Disease	Abdominal Aortic Aneurysm	OMA1 FERMT1 PCIF1	1.71e-03	68	102	3	EFO_0004214
Disease	sphingosine 1-phosphate measurement	OMA1 ITPR1	1.75e-03	18	102	2	EFO_0800185
Disease	anorectal malformation	RTEL1 THBS2	1.95e-03	19	102	2	MONDO_0019938
Disease	low affinity immunoglobulin gamma Fc region receptor II-b measurement	FCGR2C FCGR2B	3.37e-03	25	102	2	EFO_0021970

Protein segments in the cluster

Peptide	Gene	Start	Entry
QGNPHWIVEEREDGT	AHSA2P	6	Q719I0
EQSHWAAAEVPEVLQ	EXOC3L4	401	Q17RC7
IIQNGHEEEPLENTW	HSD3B2	136	P26439
LPQEQLTHWAVGTIE	C6orf62	206	Q9GZU0
PEQVVLVSGHLDSWD	CPQ	281	Q9Y646
PIWGDTVNVEIQAED	CCDC33	291	Q8N5R6
PEEWVLLHVVQGQIG	C6orf120	36	Q7Z4R8
WPLENVDGIHELQDT	ADGRD1	46	Q6QNK2
AEEAGIWQHVVQELP	CIITA	816	P33076
EWLVLQTPHLEFQEG	FCGR2B	131	P31994
TAQIWIEGVVEGHII	GPR32	201	O75388
IHQGEEEGPLDIWAV	FBXO34	96	Q9NWN3
SWELVVRVDHPNEEQ	FERMT1	11	Q9BQL6
PVHDAVVNDNLETIW	BCORL1	1566	Q5H9F3
IVEVAGQDISHWFDP	CYB5D1	61	Q6P9G0
PDLGVIWVDAHTDIN	ARG1	116	P05089
QPEKVQTLEAWVIHG	CD38	231	P28907
SKEHGIQVQEWINPV	RAD17	151	O75943
IVQGHIEWQTADVIV	PARP9	321	Q8IXQ6
PSGEDQNDWVAVHVV	MOB3B	51	Q86TA1
WQPEVQELINHLEGV	CFAP99	156	D6REC4
GWIQTVEDLHERVPE	RAB3GAP2	431	Q9H2M9
WIDIHNPATNEVIGR	ALDH6A1	56	Q02252
FHPNGLEVIINTEIW	DCAF1	1266	Q9Y4B6
GHIASVLNAWPEDVI	ME1	131	P48163
GVIHHELQVVEEGLW	MED13L	96	Q71F56
LWEVEVVQHDPCRGG	ITPR1	281	Q14643
WEEQVETGQTHHPDL	MSS51	336	Q4VC12
IVDLWHPNVAGAERQ	ASPHD1	366	Q5U4P2
LGQDQIWSEHPLQIE	DOP1B	1426	Q9Y3R5
AIPNARIELQEWEHV	CPSF1	1086	Q10570
EWLVLQTPHLEFQEG	FCGR2C	131	P31995
GQVHEVPEGWLIFVA	COL18A1	1456	P39060
QIAHPDGIAVDWVAR	LRP6	401	O75581
EAAQQHPEEVRGLWQ	DPP3	131	Q9NY33
HQEEQEDVNKPAWGV	MFSD6	676	Q6ZSS7
ELPWVHLQGVQDGDL	PCNT	646	O95613
GDVITVLEQHPDGRW	CASKIN2	306	Q8WXE0
TLVAHQGNWETIPEE	DSTYK	176	Q6XUX3
WHETDVNIDGDIVPA	MAB21L3	126	Q8N8X9
GQVLQVQAPWVEHFI	DDO	201	Q99489
TQDEAGLEVHQFWPL	FZD8	61	Q9H461
GLEVHQFWPLVEIQC	FZD8	66	Q9H461
LQWVVENSEHSPEVE	CHRNA6	416	Q15825
AVVEWHETSLVPGNI	ADAMTS3	106	O15072
NGILTWEDFELVNPH	HECTD1	2341	Q9ULT8
RVPHVQGEQQEWEGT	C1QTNF1	26	Q9BXJ1
LVQDLPEELVHAGWE	PCIF1	36	Q9H4Z3
HQPVSDWGEEVELNS	CCDC9	496	Q9Y3X0
ILDAHIEVNVGWAEP	GALNT8	276	Q9NY28
PEWVEHINDTEVDIG	CNTN1	331	Q12860
ILISWGIDVDQEIPH	ASB5	186	Q8WWX0
SVVVHQVERVSGPWE	LTBP4	231	Q8N2S1
APIDEHWIIECNDGV	GAMT	81	Q14353
GNVVQLDRWDLHAEP	DGKZ	411	Q13574
WHQAVDTLPEEQLVV	HELZ2	481	Q9BYK8
WKDVNINIIDTPGHV	GFM1	111	Q96RP9
ENQEHSLGTEPIITW	SLC13A4	441	Q9UKG4
NAVFTPEDWHGIQEI	SACS	161	Q9NZJ4
EGSELNIPHVVAWAQ	CAMSAP2	726	Q08AD1
NIPHVVAWAQIPEET	CAMSAP2	731	Q08AD1
WLSEGEHVVDVVVEN	PKD1	901	P98161
IDEGQVTHNWDEVDP	HGD	76	Q93099
AAWLGQDVVPLHTQV	OR52I2	291	Q8NH67
VLVAVLQAHAWEDVG	GRIN3B	161	O60391
ENPHIIDKHQIWVGV	RTEL1	501	Q9NZ71
PIAQWHTLQVEEEVD	SYT1	401	P21579
HIGRVVELQLEDNPW	SLITRK4	201	Q8IW52
PWGIVEVENQAHCDF	SEPTIN5	266	Q99719
LPWAVQAVEHEEVAQ	TMCO3	16	Q6UWJ1
AWIVEAEEILQGQDP	SYNE1	7366	Q8NF91
EGESNPEIVIWAEHV	SYNM	316	O15061
ETGASQDWLPHVEVQ	MRM3	326	Q9HC36
APWLNLHGQQEVEAI	PIK3R6	721	Q5UE93
VVGFWPAQSIQDDIH	MTR	1031	Q99707
TDVNAEIHDWVIEPV	NEO1	996	Q92859
EIHDWVIEPVVGNRL	NEO1	1001	Q92859
GHVLPDEELQWVFVN	SIGMAR1	71	Q99720
VQVVPHITDAIQEWV	CTPS1	111	P17812
AVSEAVRQLWHEGPQ	SLC25A53	61	Q5H9E4
RVIPHDGAEDLWIQA	PLB1	131	Q6P1J6
DVPGISQINWVIHVV	OMA1	276	Q96E52
IHEIAVLELAQDNPW	STK17A	106	Q9UEE5
GAVEDLQDVWLVHSV	ACTN3	541	Q08043
QVSVVHPNLWEEVTD	ASPRV1	216	Q53RT3
VQVVPHITDAVQEWV	CTPS2	111	Q9NRF8
LHWAPVEEAGDSTQI	TBC1D17	46	Q9HA65
EEIQTWVREQHPENG	ZSCAN32	91	Q9NX65
WVREQHPENGEEAVA	ZSCAN32	96	Q9NX65
ALVQVNDPDAEVWVV	TMEM220	21	Q6QAJ8
GENNWSLPELVHAVV	SESN3	181	P58005
QVGQHIEVDPDWEAA	UBR1	521	Q8IWV7
IQIWVRQQHPESGEE	SCAND2P	101	Q9GZW5
WGEPVNLREQHDALE	USP9Y	1676	O00507
VICSHIAQDLWPEQG	ZNF730	76	Q6ZMV8
PEEQWQRAIHERGEA	ZNF512B	496	Q96KM6
SWVREQHPESGEEVV	ZKSCAN4	111	Q969J2
LRVWVQLHNPESGEE	ZNF445	111	P59923
VWHETEEGVLVVNVT	ZNF608	381	Q9ULD9
EQGEPWTVENEIHSQ	ZNF613	61	Q6PF04
HLEEVVQEAAGEWQA	ZNF236	1826	Q9UL36
WVREHNPESGEEVVT	ZBED9	111	Q6R2W3
DPNWVIRHQGKELVQ	THBS2	976	P35442
GGVEDQEEWHAQVVE	ZBED1	556	O96006
TRQVGQHIEMEPEWE	UBR2	521	Q8IWV8
ELQAWVQEQHPESGE	ZSCAN12	101	O43309
LLVAWQDQEGVHATP	THOC1	616	Q96FV9
HGQVLWILEEESPSQ	ZNF487	91	B1APH4
NPHIEAILENEDWIE	TMEM98	71	Q9Y2Y6
QCHQVVGVDVEWTPV	EXD3	391	Q8N9H8
VQVVDDEDNEHWISP	MYO7A	36	Q13402