Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	pancreatic polypeptide receptor activity	NPY4R2 NPY4R	7.03e-05	4	69	2	GO:0001602
GeneOntologyBiologicalProcess	dopamine biosynthetic process	TGFB2 AGTR2 GCH1	2.36e-05	17	69	3	GO:0042416
GeneOntologyBiologicalProcess	establishment of cell polarity	DOCK2 FRMD4A AMOT INSC SPAG5 FOXJ1	2.81e-05	177	69	6	GO:0030010
GeneOntologyBiologicalProcess	calcium ion export	ATP2B1 ATP2B4	6.59e-05	4	69	2	GO:1901660
GeneOntologyBiologicalProcess	glutamine family amino acid catabolic process	GLS GLUL ATP2B4	9.89e-05	27	69	3	GO:0009065
GeneOntologyBiologicalProcess	catechol-containing compound biosynthetic process	TGFB2 AGTR2 GCH1	1.23e-04	29	69	3	GO:0009713
GeneOntologyBiologicalProcess	catecholamine biosynthetic process	TGFB2 AGTR2 GCH1	1.23e-04	29	69	3	GO:0042423
Domain	NPY4_rcpt	NPY4R2 NPY4R	1.27e-05	2	67	2	IPR001933
Domain	ATP2B1/4	ATP2B1 ATP2B4	1.27e-05	2	67	2	IPR030319
Domain	ATP_Ca_trans_C	ATP2B1 ATP2B4	7.57e-05	4	67	2	IPR022141
Domain	ATP_Ca_trans_C	ATP2B1 ATP2B4	7.57e-05	4	67	2	PF12424
Domain	P-type_ATPase_IIB	ATP2B1 ATP2B4	7.57e-05	4	67	2	IPR006408
Domain	DUF4704	WDFY3 LRBA	1.26e-04	5	67	2	IPR031570
Domain	DUF4704	WDFY3 LRBA	1.26e-04	5	67	2	PF15787
Domain	PH_BEACH	WDFY3 LRBA	1.88e-04	6	67	2	PF14844
Domain	ARM-type_fold	DOCK2 USP34 INSC MROH2A TTI1 WDFY3 LRBA	2.08e-04	339	67	7	IPR016024
Domain	PH-BEACH_dom	WDFY3 LRBA	3.50e-04	8	67	2	IPR023362
Domain	-	WDFY3 LRBA	3.50e-04	8	67	2	2.30.29.40
Domain	PH_BEACH	WDFY3 LRBA	3.50e-04	8	67	2	PS51783
Domain	ARM-like	DOCK2 INSC MROH2A TTI1 WDFY3 LRBA	4.12e-04	270	67	6	IPR011989
Domain	BEACH_dom	WDFY3 LRBA	4.49e-04	9	67	2	IPR000409
Domain	NPY_rcpt	NPY4R2 NPY4R	4.49e-04	9	67	2	IPR000611
Domain	BEACH	WDFY3 LRBA	4.49e-04	9	67	2	PS50197
Domain	Beach	WDFY3 LRBA	4.49e-04	9	67	2	PF02138
Domain	-	WDFY3 LRBA	4.49e-04	9	67	2	1.10.1540.10
Domain	Beach	WDFY3 LRBA	4.49e-04	9	67	2	SM01026
Domain	VWD	VWF MUC4	1.47e-03	16	67	2	SM00216
Domain	-	ATP2B1 ATP2B4	1.47e-03	16	67	2	1.20.1110.10
Domain	VWF_type-D	VWF MUC4	1.47e-03	16	67	2	IPR001846
Domain	VWFD	VWF MUC4	1.47e-03	16	67	2	PS51233
Domain	ATPase_P-typ_TM_dom	ATP2B1 ATP2B4	1.47e-03	16	67	2	IPR023298
Domain	VWD	VWF MUC4	1.47e-03	16	67	2	PF00094
Domain	ATPase_P-typ_cation-transptr_C	ATP2B1 ATP2B4	1.67e-03	17	67	2	IPR006068
Domain	Cation_ATPase_C	ATP2B1 ATP2B4	1.67e-03	17	67	2	PF00689
Domain	Cation_ATPase_N	ATP2B1 ATP2B4	1.87e-03	18	67	2	PF00690
Domain	Cation_ATPase_N	ATP2B1 ATP2B4	1.87e-03	18	67	2	SM00831
Domain	ATPase_P-typ_cation-transptr_N	ATP2B1 ATP2B4	2.08e-03	19	67	2	IPR004014
Domain	ATPase_P-typ_cyto_domN	ATP2B1 ATP2B4	6.99e-03	35	67	2	IPR023299
Pubmed	The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate.	GLS GLUL SLC1A5	1.62e-07	6	71	3	21757002
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	FRMD4A CARMIL1 PCDH11X KIAA1549 LRBA ATP2B1 ATP2B4 SLC1A5 FAM83B	2.38e-06	569	71	9	30639242
Pubmed	Functional and structural demonstration of the presence of Ca-ATPase (PMCA) in both microvillous and basal plasma membranes from syncytiotrophoblast of human term placenta.	ATP2B1 ATP2B4	4.11e-06	2	71	2	18657858
Pubmed	Targeting of glutamine transporter ASCT2 and glutamine synthetase suppresses gastric cancer cell growth.	GLUL SLC1A5	4.11e-06	2	71	2	29435734
Pubmed	The influence of membrane lipid structure on plasma membrane Ca2+ -ATPase activity.	ATP2B1 ATP2B4	4.11e-06	2	71	2	16412504
Pubmed	Distinct roles of PMCA isoforms in Ca2+ homeostasis of bladder smooth muscle: evidence from PMCA gene-ablated mice.	ATP2B1 ATP2B4	4.11e-06	2	71	2	16956963
Pubmed	Localization of two genes encoding plasma membrane Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and 12q21-23.	ATP2B1 ATP2B4	4.11e-06	2	71	2	1674727
Pubmed	Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4.	ATP2B1 ATP2B4	4.11e-06	2	71	2	15178683
Pubmed	Platelet count mediates the contribution of a genetic variant in LRRC16A to ARDS risk.	CARMIL1 JMJD1C	4.11e-06	2	71	2	25254322
Pubmed	Role of plasma membrane Ca2+-ATPase in contraction-relaxation processes of the bladder: evidence from PMCA gene-ablated mice.	ATP2B1 ATP2B4	4.11e-06	2	71	2	16291816
Pubmed	Regulation of plasma membrane Ca2+-ATPase by small GTPases and phosphoinositides in human platelets.	ATP2B1 ATP2B4	4.11e-06	2	71	2	10748016
Pubmed	Selective upregulation of the expression of plasma membrane calcium ATPase isoforms upon differentiation and 1,25(OH)2D3-vitamin treatment of colon cancer cells.	ATP2B1 ATP2B4	4.11e-06	2	71	2	26116539
Pubmed	Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival.	ATP2B1 ATP2B4	4.11e-06	2	71	2	23266958
Pubmed	The expression of glutamine-metabolism-related proteins in breast phyllodes tumors.	GLS SLC1A5	1.23e-05	3	71	2	23636801
Pubmed	In Silico Preliminary Association of Ammonia Metabolism Genes GLS, CPS1, and GLUL with Risk of Alzheimer's Disease, Major Depressive Disorder, and Type 2 Diabetes.	GLS GLUL	1.23e-05	3	71	2	29441491
Pubmed	A complex of Neuroplastin and Plasma Membrane Ca2+ ATPase controls T cell activation.	ATP2B1 ATP2B4	1.23e-05	3	71	2	28827723
Pubmed	Expression of enzymes regulating placental ammonia homeostasis in human fetal growth restricted pregnancies.	GLS GLUL	1.23e-05	3	71	2	19500843
Pubmed	Plasma membrane Ca2+ ATPase 1 (PMCA1) but not PMCA4 is critical for B-cell development and Ca2+ homeostasis in mice.	ATP2B1 ATP2B4	1.23e-05	3	71	2	33098669
Pubmed	Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer.	GLS SLC1A5	1.23e-05	3	71	2	23507704
Pubmed	Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.	NPY4R2 NPY4R	1.23e-05	3	71	2	8643460
Pubmed	CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity.	ATP2B1 ATP2B4	1.23e-05	3	71	2	15133509
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	USP34 AMOT RALGPS1 KIF21A KIAA1549 MTREX ZZEF1 CLOCK	1.25e-05	529	71	8	14621295
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	USP34 AMOT GLS ZMYND8 LRBA JMJD1C SPAG5	2.36e-05	418	71	7	34709266
Pubmed	Cell-specific expression of plasma membrane calcium ATPase isoforms in retinal neurons.	ATP2B1 ATP2B4	2.46e-05	4	71	2	12209837
Pubmed	Expression and role of calcium-ATPase pump and sodium-calcium exchanger in differentiated trophoblasts from human term placenta.	ATP2B1 ATP2B4	2.46e-05	4	71	2	12784250
Pubmed	Calcium pumps of plasma membrane and cell interior.	ATP2B1 ATP2B4	2.46e-05	4	71	2	15101689
Pubmed	The plasma membrane calcium pump in health and disease.	ATP2B1 ATP2B4	2.46e-05	4	71	2	23413890
Pubmed	Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.	ATP2B1 ATP2B4	2.46e-05	4	71	2	8245032
Pubmed	Plasma membrane calcium ATPases as critical regulators of calcium homeostasis during neuronal cell function.	ATP2B1 ATP2B4	2.46e-05	4	71	2	10577388
Pubmed	Structural organization, ion transport, and energy transduction of P-type ATPases.	ATP2B1 ATP2B4	2.46e-05	4	71	2	8634322
Pubmed	Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.	ATP2B1 ATP2B4	2.46e-05	4	71	2	7989379
Pubmed	Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps.	ATP2B1 ATP2B4	2.46e-05	4	71	2	11152753
Pubmed	Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.	NPY4R2 NPY4R	2.46e-05	4	71	2	7592911
Pubmed	The sarcolemmal calcium pump, alpha-1 syntrophin, and neuronal nitric-oxide synthase are parts of a macromolecular protein complex.	ATP2B1 ATP2B4	2.46e-05	4	71	2	16735509
Pubmed	PMCA1 depletion in mouse eggs amplifies calcium signaling and impacts offspring growth†.	ATP2B1 ATP2B4	2.46e-05	4	71	2	36130203
Pubmed	Ca2+ Homeostasis by Plasma Membrane Ca2+ ATPase (PMCA) 1 Is Essential for the Development of DP Thymocytes.	ATP2B1 ATP2B4	2.46e-05	4	71	2	36674959
Pubmed	Developmental expression of the four plasma membrane calcium ATPase (Pmca) genes in the mouse.	ATP2B1 ATP2B4	2.46e-05	4	71	2	10434059
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	CARMIL1 PCDH19 USP12 LRBA ATP2B1 ATP2B4 FAM83B	2.47e-05	421	71	7	36976175
Pubmed	Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.	NPY4R2 NPY4R	4.09e-05	5	71	2	7493937
Pubmed	Increased maternofetal calcium flux in parathyroid hormone-related protein-null mice.	ATP2B1 ATP2B4	4.09e-05	5	71	2	18258656
Pubmed	Defective vascular development in connexin 45-deficient mice.	TGFB2 VWF	4.09e-05	5	71	2	10976050
Pubmed	Differential regulation of the apical plasma membrane Ca(2+) -ATPase by protein kinase A in parotid acinar cells.	ATP2B1 ATP2B4	4.09e-05	5	71	2	17938178
Pubmed	Association of TGFBR2 polymorphism with risk of sudden cardiac arrest in patients with coronary artery disease.	TGFB2 SMAD1	4.09e-05	5	71	2	19959123
Pubmed	Macrophage-derived glutamine boosts satellite cells and muscle regeneration.	GLS GLUL	4.09e-05	5	71	2	33116312
Pubmed	Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants.	ATP2B1 ATP2B4	6.13e-05	6	71	2	12763866
Pubmed	An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia.	GLS GLUL	6.13e-05	6	71	2	15642443
Pubmed	Novel roles of Pkd2 in male reproductive system development.	PKD2 SMAD1	6.13e-05	6	71	2	24951251
Pubmed	BMP signaling suppresses Gemc1 expression and ependymal differentiation of mouse telencephalic progenitors.	SMAD1 FOXJ1	6.13e-05	6	71	2	33436697
Pubmed	Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange.	ATP2B1 ATP2B4	6.13e-05	6	71	2	12767889
Pubmed	mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia.	GLUL PSMB8 SMAD1	7.63e-05	40	71	3	34677125
Pubmed	Serum response factor, its cofactors, and epithelial-mesenchymal signaling in urinary bladder smooth muscle formation.	TGFB2 AGTR2	8.57e-05	7	71	2	16466398
Pubmed	POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters.	ATP2B1 ATP2B4	8.57e-05	7	71	2	22084111
Pubmed	CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage.	FANCD2 SPAG5	8.57e-05	7	71	2	20805509
Pubmed	Arid3b is essential for second heart field cell deployment and heart patterning.	TGFB2 INSC SMAD1	9.49e-05	43	71	3	25336743
Pubmed	Gene knockout studies of Ca2+-transporting ATPases.	ATP2B1 ATP2B4	1.14e-04	8	71	2	10951186
Pubmed	Tubedown-1 in remodeling of the developing vitreal vasculature in vivo and regulation of capillary outgrowth in vitro.	TGFB2 VWF	1.14e-04	8	71	2	12217325
Pubmed	A transient wave of BMP signaling in the retina is necessary for Müller glial differentiation.	GLUL SMAD1	1.14e-04	8	71	2	25605781
Pubmed	LZTR1 is a regulator of RAS ubiquitination and signaling.	SEPTIN5 ATP2B1 ATP2B4 SLC1A5	1.36e-04	127	71	4	30442766
Pubmed	Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle.	ATP2B1 ATP2B4	1.47e-04	9	71	2	12660151
Pubmed	Prdm16 is required for normal palatogenesis in mice.	TGFB2 SMAD1	1.47e-04	9	71	2	20007998
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	FANCD2 USP34 FAM114A1 KIF21A GLS GLUL PSMB8 TTI1 LRBA ZZEF1 VASP	1.69e-04	1455	71	11	22863883
Pubmed	Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J.	MROH2A MUC4 JMJD1C	1.98e-04	55	71	3	29997285
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	AMOT KIAA1549 LRBA JMJD1C FAM83B	2.06e-04	263	71	5	34702444
Pubmed	Multiple steps characterise ventricular layer attrition to form the ependymal cell lining of the adult mouse spinal cord central canal.	SMAD1 FOXJ1	2.23e-04	11	71	2	31670387
Pubmed	Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.	GLUL RYK	2.23e-04	11	71	2	20084116
Pubmed	Precise spatial restriction of BMP signaling in developing joints is perturbed upon loss of embryo movement.	COL26A1 SMAD1	2.23e-04	11	71	2	29467244
Pubmed	Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum.	TGFB2 SMAD1	2.68e-04	12	71	2	15923624
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	FRMD4A PCDH19 PCDH11X JMJD1C	2.78e-04	153	71	4	10718198
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	FANCD2 TGFB2 USP34 TTI1 MFSD8 WDFY3 LRBA ATP2B4 VASP	3.02e-04	1061	71	9	33845483
Pubmed	FISH mapping of three ammonia metabolism genes (Glul, Cps1, Glud1) in rat, and the chromosomal localization of GLUL in human and Cps1 in mouse.	GLS GLUL	3.16e-04	13	71	2	9107685
Pubmed	Initial Suppression of Transforming Growth Factor-β Signaling and Loss of TGFBI Causes Early Alveolar Structural Defects Resulting in Bronchopulmonary Dysplasia.	TGFB2 VWF	3.16e-04	13	71	2	26878215
Pubmed	Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis.	GLUL SMAD1	3.16e-04	13	71	2	20065295
Pubmed	Tbx6 controls left-right asymmetry through regulation of Gdf1.	PKD2 FOXJ1	3.16e-04	13	71	2	29650695
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	AMOT CARMIL1 PKD2 CCDC150 TTI1 CLOCK NDUFS1 VASP SPAG5 FOXJ1	3.39e-04	1321	71	10	27173435
Pubmed	140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.	SEPTIN5 KIF21A ATP2B1 ATP2B4	3.54e-04	163	71	4	16512683
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	PSMB8 TTI1 LRBA ATP2B1 ATP2B4 NDUFS1 ITIH2	3.54e-04	647	71	7	26618866
Pubmed	Mutation in Bmpr1b Leads to Optic Disc Coloboma and Ventral Retinal Gliosis in Mice.	GLUL SMAD1	3.68e-04	14	71	2	32106289
Pubmed	A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.	CARMIL1 JMJD1C	3.68e-04	14	71	2	22423221
Pubmed	An atypical canonical bone morphogenetic protein (BMP) signaling pathway regulates Msh homeobox 1 (Msx1) expression during odontogenesis.	TGFB2 SMAD1	3.68e-04	14	71	2	25274628
Pubmed	Absence of layer-specific cadherin expression profiles in the neocortex of the reeler mutant mouse.	PCDH19 PCDH11X	3.68e-04	14	71	2	20847152
Pubmed	E3 ubiquitin ligase MDM2 acts through p53 to control respiratory progenitor cell number and lung size.	SMAD1 FOXJ1	4.24e-04	15	71	2	31767619
Pubmed	The characterization of mice with a targeted combined deficiency of protein c and factor XI.	TGFB2 VWF	4.24e-04	15	71	2	11159184
Pubmed	Betaglycan is required for the establishment of nephron endowment in the mouse.	TGFB2 SMAD1	4.24e-04	15	71	2	21533152
Pubmed	Impairment of endothelial-mesenchymal transformation during atrioventricular cushion formation in Tmem100 null embryos.	TGFB2 SMAD1	4.84e-04	16	71	2	25318679
Pubmed	A global genomic transcriptional code associated with CNS-expressed genes.	TGFB2 INSC CARMIL1 LRBA NDUFS1	4.92e-04	318	71	5	16919269
Pubmed	Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.	HTR1E NPY4R AGTR2	4.95e-04	75	71	3	2834384
Pubmed	An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.	TGFB2 SMAD1	6.16e-04	18	71	2	17350578
Pubmed	Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86.	MARCHF8 VASP	6.16e-04	18	71	2	35411049
Pubmed	E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta.	TGFB2 SMAD1	6.16e-04	18	71	2	20530870
Pubmed	Smad1 and its target gene Wif1 coordinate BMP and Wnt signaling activities to regulate fetal lung development.	SMAD1 FOXJ1	6.16e-04	18	71	2	21270055
Pubmed	New gene functions in megakaryopoiesis and platelet formation.	VWF CARMIL1 JMJD1C	6.21e-04	81	71	3	22139419
Pubmed	Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation.	SMAD1 FOXJ1	6.87e-04	19	71	2	18258849
Pubmed	Sequential Ligand-Dependent Notch Signaling Activation Regulates Valve Primordium Formation and Morphogenesis.	TGFB2 SMAD1	6.87e-04	19	71	2	27056911
Pubmed	Systematic Affinity Purification Coupled to Mass Spectrometry Identified p62 as Part of the Cannabinoid Receptor CB2 Interactome.	FANCD2 ZZEF1 ATP2B1	6.90e-04	84	71	3	31616248
Pubmed	An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studies.	AGTR2 ATP2B1 ATP2B4	6.90e-04	84	71	3	15123239
Pubmed	Chronic otitis media is initiated by a bulla cavitation defect in the FBXO11 mouse model.	SMAD1 FOXJ1	7.62e-04	20	71	2	30898767
Pubmed	Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex.	FANCD2 TGFB2 SPAG5	7.64e-04	87	71	3	33798452
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FRMD4A ZMYND8 WDFY3	7.64e-04	87	71	3	12465718
Pubmed	Mendelian randomization and experimental IUGR reveal the adverse effect of low birth weight on lung structure and function.	VWF SMAD1	8.41e-04	21	71	2	33372189
Pubmed	A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.	TGFB2 PCDH19 PCDH11X	8.71e-04	91	71	3	28558017
Cytoband	3q22	ACKR4 RYK	2.42e-05	5	72	2	3q22
GeneFamily	ATPases Ca2+ transporting	ATP2B1 ATP2B4	2.77e-04	9	51	2	1209
GeneFamily	WD repeat domain containing\|BEACH domain containing	WDFY3 LRBA	2.77e-04	9	51	2	1230
GeneFamily	Non-clustered protocadherins	PCDH19 PCDH11X	5.06e-04	12	51	2	21
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	TGFB2 USP34 ZMYND8 PKD2 USP12 WDFY3 MTREX ZZEF1 CLOCK ATP2B1 ATP2B4 RYK	1.85e-06	856	68	12	M4500
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	USP34 KIF21A WDFY3 CHML CLOCK NDUFS1	7.12e-07	193	72	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	CCNH USP34 GLS LRBA JMJD1C	1.12e-05	181	72	5	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	ILEUM-inflamed-(3)_MNP-(3)_moDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	CCNH FRMD4A ZMYND8 CHML JMJD1C	1.31e-05	187	72	5	0099def970fbc828756fbf853eca2ce77b8cd342
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK2 GLUL ATP2B1 JMJD1C VASP	1.65e-05	196	72	5	fe8d3f45a64323947c36b127355d5940eb56c0ca
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK2 GLUL ATP2B1 JMJD1C VASP	1.65e-05	196	72	5	526d037bb12d81f1c235c60ddc787fbad0bbad77
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK2 GLUL ATP2B1 JMJD1C VASP	1.69e-05	197	72	5	3cd1c816bc7a57278b2ef615b69545356ab8f522
Computational	Genes in the cancer module 205.	FANCD2 FAM114A1 SEPTIN5 GLS TSHR CHML CLOCK	1.85e-04	305	43	7	MODULE_205
Disease	immature platelet fraction	VWF SEPTIN5 CARMIL1 ZMYND8 JMJD1C	8.97e-06	114	72	5	EFO_0009187
Disease	immature platelet measurement	VWF SEPTIN5 CARMIL1 ZMYND8 JMJD1C	1.11e-05	119	72	5	EFO_0803541
Disease	Antihypertensive use measurement	SEPTIN5 RALGPS1 LRBA ATP2B1 ATP2B4 RYK	4.72e-05	265	72	6	EFO_0009927
Disease	Hailey-Hailey disease (implicated_via_orthology)	ATP2B1 ATP2B4	8.75e-05	6	72	2	DOID:0050429 (implicated_via_orthology)
Disease	end stage renal disease (is_implicated_in)	SLC9A5 VWF AGTR2	1.39e-04	41	72	3	DOID:783 (is_implicated_in)
Disease	Early Pregnancy Loss	GLS ACKR4 MUC4 SPAG5	1.49e-04	109	72	4	C3830362
Disease	Miscarriage	GLS ACKR4 MUC4 SPAG5	1.49e-04	109	72	4	C4552766
Disease	Spontaneous abortion	GLS ACKR4 MUC4 SPAG5	1.49e-04	109	72	4	C0000786
Disease	Abortion, Tubal	GLS ACKR4 MUC4 SPAG5	1.49e-04	109	72	4	C0000822
Disease	cystic fibrosis, lung disease severity measurement	AGTR2 MUC4	2.09e-04	9	72	2	EFO_0007744, MONDO_0009061
Disease	hypertension (biomarker_via_orthology)	VWF AGTR2 GCH1 CLOCK ATP2B1	2.37e-04	227	72	5	DOID:10763 (biomarker_via_orthology)
Disease	C-C motif chemokine 28 measurement	JMJD1C NDUFS1	3.81e-04	12	72	2	EFO_0020199
Disease	juvenile idiopathic arthritis	CARMIL1 JMJD1C SMAD1	7.98e-04	74	72	3	EFO_0002609
Disease	Hypertensive disease	VWF AGTR2 GCH1 ATP2B1	1.22e-03	190	72	4	C0020538
Disease	liver fibrosis measurement	VWF CARMIL1 JMJD1C	1.23e-03	86	72	3	EFO_0010576
Disease	cholelithiasis	MARCHF8 LRBA JMJD1C	1.32e-03	88	72	3	EFO_0004799
Disease	antiphospholipid syndrome	FRMD4A TSHR	1.57e-03	24	72	2	EFO_0002689
Disease	Lymphatic Metastasis	CCNH TSHR	1.84e-03	26	72	2	C0024232
Disease	immature platelet count	VWF CARMIL1 JMJD1C	2.24e-03	106	72	3	EFO_0803544
Disease	Mental Retardation, X-Linked	PCDH19 AGTR2	2.28e-03	29	72	2	C1136249
Disease	gallstones	MARCHF8 LRBA JMJD1C	2.37e-03	108	72	3	EFO_0004210

Protein segments in the cluster

Peptide	Gene	Start	Entry
SSSSATLPLMMKCVE	SLC1A5	351	Q15758
TEQLSCMRPAKSLMS	AMOT	776	Q4VCS5
NRTCLSQLLDIMKSM	CCNH	241	P51946
MNITNCTTEASMAIR	HTR1E	1	P28566
SMSCRKSSSLREMET	AGTR2	346	P50052
AICSDKTGTLTMNRM	ATP2B1	471	P20020
AICSDKTGTLTMNRM	ATP2B4	461	P23634
VTELCSSTMTCMKDT	CHML	491	P26374
NMMCQLSVVESKSAT	RALGPS1	346	Q5JS13
VAMTAKDCSIMIALS	IPPK	396	Q9H8X2
KECMDMLRLTLQTTS	GLS	176	O94925
SLQERTSSMANISMC	MFSD8	161	Q8NHS3
ISVSAASKLLSNMMC	PSMB8	146	P28062
LCMTVLEESSISLMS	KIAA1549	451	Q9HCM3
LITSCNMSKRMDIAI	ACKR4	271	Q9NPB9
SPKCIISLEVMSSSM	PCDH19	96	Q8TAB3
CSVTNTSMMTSEKIT	MUC4	251	Q99102
SSSLAIREMQIKTTM	nan	1096	O00370
KVQSTITSRMATTMI	ITIH2	76	P19823
MSAFIQCMSVTVSIL	NPY4R	116	P50391
PSSVMSAVNTMCNTK	JMJD1C	1381	Q15652
EMSTCIINKVMSAIS	FSIP2	4176	Q5CZC0
KDVSSLRMMLCTTSQ	CWF19L1	131	Q69YN2
METSSMLSSLNDECK	FAM83B	1	Q5T0W9
LVCMKSSSSVVELVM	LRBA	1841	P50851
QMTSSERRKIMCSVT	MARCHF8	146	Q5T0T0
VVRSCTPMKESTTME	PCDH11X	1016	Q9BZA7
MKTSVLLAITAMCSD	OOSP4B	1	A0A2R8Y4Y8
ITLILNVTRLCMMSS	MFAP3	161	P55082
SRVTRMPQMCKATSA	FRMD4A	971	Q9P2Q2
ATMLCSDSSLQRQVM	CARD6	381	Q9BX69
LSCMLQTVTMEKARI	CCDC150	356	Q8NCX0
RQMSIISLASMNSDC	DOCK2	1641	Q92608
MIQSSQPMSLKLTCS	GDF5-AS1	1	Q5U4N7
LLSSLCMAMVRKSSA	IDI2-AS1	21	Q9NZ38
CMAMQASKATKITLS	FOXJ1	131	Q92949
SMKACVSETLSMLGQ	INSC	211	Q1MX18
SAQMIVETEKCSISM	CARMIL1	81	Q5VZK9
AECIETQSKAMTMLT	ZMYND8	136	Q9ULU4
SEIQVTMMLTESCKL	RYK	371	P34925
LSLCTQISMLEMRNS	BVES	281	Q8NE79
MNCTRLSDMSERLTT	COL26A1	131	Q96A83
LESMSAKERSFMCSL	FANCD2	771	Q9BXW9
RTKTLMERTVSLSQM	FAM114A1	251	Q8IWE2
KMTVFQTTMCSILTR	MROH2A	1566	A6NES4
TNLRHTCKRIMDMVS	GLUL	111	P15104
AEMSIMTTELQSLCS	SPAG5	971	Q96R06
CIQQMTSKLTQDSRM	SEPTIN5	311	Q99719
MTDSISRASQTMAKC	NDUFS1	696	P28331
MNSKTVTSTMLGVFR	GCH1	221	P30793
KSMMLRARSSECLSQ	SHROOM4	656	Q9ULL8
TMKTLASCAETVIFM	SLC9A5	331	Q14940
ETVYELTKMCTIRMS	SMAD1	401	Q15797
MLFTVSCSKMSSIVD	CLOCK	1	O15516
LSTCSTLDMDQFMRK	TGFB2	21	P61812
SLDISSKCMMNTLSS	ZNF320	46	A2RRD8
VDCMTTMSVPSTLVK	WDFY3	141	Q8IZQ1
MKQTMVDSSCRILTS	VWF	1051	P04275
TASCLVMTTEILRSM	MTREX	221	P42285
TTRTVNTESEMMQCL	KIF21A	191	Q7Z4S6
MEILMTVSKFASICT	USP12	1	O75317
MSAFIQCMSVTVSIL	NPY4R2	116	P0DQD5
SESEMRKTSNSCIME	SMTNL2	141	Q2TAL5
RTMSQLSTTMSRCAK	PKD2	581	Q13563
TTELSLCRITGMKEM	TRIML1	266	Q8N9V2
SLDISSKCMMEFSSI	ZNF888	46	P0CJ79
MCTMRSSVLKESLDQ	ZZEF1	211	O43149
KCMESLMIASSSLEQ	USP34	1141	Q70CQ2
TNTLMVALSSCTMVL	TGM7	631	Q96PF1
LISQVATSTMMDVCR	TTI1	666	O43156
LESLMCNESSMQSLR	TSHR	296	P16473
MSETVICSSRATVML	VASP	1	P50552
TMNLTSLCEKVRAEM	NLRP13	91	Q86W25
VDMTLCTDMSDITKS	NAT8	86	Q9UHE5