Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA helicase activity	ERCC3 SUPV3L1 MCM9 CHD8 XRCC5	4.92e-06	62	80	5	GO:0003678
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	ERCC3 SUPV3L1 MCM9 CHD9 CHD8 XRCC5	1.20e-05	127	80	6	GO:0008094
GeneOntologyMolecularFunction	helicase activity	ERCC3 SUPV3L1 MCM9 CHD9 CHD8 XRCC5	4.14e-05	158	80	6	GO:0004386
GeneOntologyMolecularFunction	ATP hydrolysis activity	ABCG4 ERCC3 DNAH12 CCT5 SUPV3L1 MCM9 CHD9 CHD8 XRCC5	6.67e-05	441	80	9	GO:0016887
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERCC3 SUPV3L1 MCM9 CHD9 CHD8 XRCC5 POLK	8.68e-05	262	80	7	GO:0140097
GeneOntologyMolecularFunction	N-acetylglucosamine 6-O-sulfotransferase activity	CHST5 CHST4	3.29e-04	7	80	2	GO:0001517
GeneOntologyMolecularFunction	damaged DNA binding	ERCC3 XPA XRCC5 POLK	3.61e-04	84	80	4	GO:0003684
GeneOntologyMolecularFunction	ATP-dependent activity	ABCG4 ERCC3 DNAH12 CCT5 SUPV3L1 MCM9 CHD9 CHD8 XRCC5	7.70e-04	614	80	9	GO:0140657
GeneOntologyBiologicalProcess	DNA duplex unwinding	ERCC3 SUPV3L1 MCM9 CHD8 XRCC5	1.16e-05	78	78	5	GO:0032508
GeneOntologyBiologicalProcess	DNA geometric change	ERCC3 SUPV3L1 MCM9 CHD8 XRCC5	1.86e-05	86	78	5	GO:0032392
GeneOntologyBiologicalProcess	DNA conformation change	ERCC3 SUPV3L1 MCM9 CHD8 XRCC5	2.87e-05	94	78	5	GO:0071103
GeneOntologyBiologicalProcess	cellular response to sorbitol	MAPK13 MAP2K3	8.43e-05	4	78	2	GO:0072709
Domain	Maf_N	NRL MAF	9.00e-05	4	73	2	PF08383
Domain	Maf_TF_N	NRL MAF	9.00e-05	4	73	2	IPR013592
Domain	-	MPP1 RABL6 ABCG4 CHST5 ERCC3 DNAH12 SUPV3L1 CHST4 MCM9 CHD9 CHD8	1.42e-04	746	73	11	3.40.50.300
Domain	BRK	CHD9 CHD8	2.24e-04	6	73	2	SM00592
Domain	Na_trans_cytopl	SCN1A SCN8A	2.24e-04	6	73	2	PF11933
Domain	BRK_domain	CHD9 CHD8	2.24e-04	6	73	2	IPR006576
Domain	BRK	CHD9 CHD8	2.24e-04	6	73	2	PF07533
Domain	Na_trans_cytopl	SCN1A SCN8A	2.24e-04	6	73	2	IPR024583
Domain	Transciption_factor_Maf_fam	NRL MAF	3.12e-04	7	73	2	IPR024874
Domain	Carbohydrate_sulfotransferase	CHST5 CHST4	3.12e-04	7	73	2	IPR016469
Domain	P-loop_NTPase	MPP1 RABL6 ABCG4 CHST5 ERCC3 DNAH12 SUPV3L1 CHST4 MCM9 CHD9 CHD8	4.29e-04	848	73	11	IPR027417
Domain	Na_channel_asu	SCN1A SCN8A	6.64e-04	10	73	2	IPR001696
Domain	Na_trans_assoc	SCN1A SCN8A	6.64e-04	10	73	2	IPR010526
Domain	Na_trans_assoc	SCN1A SCN8A	6.64e-04	10	73	2	PF06512
Domain	Helicase_C	ERCC3 SUPV3L1 CHD9 CHD8	8.18e-04	107	73	4	PF00271
Domain	HELICc	ERCC3 SUPV3L1 CHD9 CHD8	8.18e-04	107	73	4	SM00490
Domain	Helicase_C	ERCC3 SUPV3L1 CHD9 CHD8	8.47e-04	108	73	4	IPR001650
Domain	HELICASE_CTER	ERCC3 SUPV3L1 CHD9 CHD8	8.77e-04	109	73	4	PS51194
Domain	HELICASE_ATP_BIND_1	ERCC3 SUPV3L1 CHD9 CHD8	8.77e-04	109	73	4	PS51192
Domain	Oxysterol-bd	OSBPL11 OSBPL10	9.70e-04	12	73	2	IPR000648
Domain	Oxysterol-bd_CS	OSBPL11 OSBPL10	9.70e-04	12	73	2	IPR018494
Domain	Oxysterol_BP	OSBPL11 OSBPL10	9.70e-04	12	73	2	PF01237
Domain	OSBP	OSBPL11 OSBPL10	9.70e-04	12	73	2	PS01013
Domain	bZIP_Maf	NRL MAF	1.14e-03	13	73	2	IPR004826
Domain	bZIP_Maf	NRL MAF	1.14e-03	13	73	2	PF03131
Domain	Channel_four-helix_dom	CACNA1F SCN1A SCN8A	1.44e-03	57	73	3	IPR027359
Domain	-	CACNA1F SCN1A SCN8A	1.44e-03	57	73	3	1.20.120.350
Domain	ADH_N	MECR VAT1L	1.75e-03	16	73	2	PF08240
Domain	PKS_ER	MECR VAT1L	1.75e-03	16	73	2	SM00829
Domain	-	NRL MAF	1.75e-03	16	73	2	1.10.880.10
Domain	PKS_ER	MECR VAT1L	1.75e-03	16	73	2	IPR020843
Domain	ADH_N	MECR VAT1L	1.75e-03	16	73	2	IPR013154
Domain	-	MECR VAT1L	2.21e-03	18	73	2	3.90.180.10
Domain	ADH_zinc_N	MECR VAT1L	2.47e-03	19	73	2	PF00107
Domain	ADH_SF_Zn-type	MECR VAT1L	2.47e-03	19	73	2	IPR002085
Domain	ADH_C	MECR VAT1L	2.47e-03	19	73	2	IPR013149
Domain	BTB	IVNS1ABP LZTR1 BTBD10 ZBTB40	3.57e-03	160	73	4	PS50097
Pathway	KEGG_MEDICUS_REFERENCE_CORE_NER_REACTION	ERCC3 GTF2H4 XPA POLK	5.67e-06	29	58	4	M47826
Pathway	REACTOME_DUAL_INCISION_IN_GG_NER	ERCC3 GTF2H4 XPA POLK	2.33e-05	41	58	4	M27595
Pathway	REACTOME_DUAL_INCISION_IN_GG_NER	ERCC3 GTF2H4 XPA POLK	2.57e-05	42	58	4	MM15306
Pathway	REACTOME_DUAL_INCISION_IN_TC_NER	ERCC3 GTF2H4 XPA POLK	1.28e-04	63	58	4	M27601
Pathway	REACTOME_DUAL_INCISION_IN_TC_NER	ERCC3 GTF2H4 XPA POLK	1.28e-04	63	58	4	MM15317
Pathway	WP_DNA_REPAIR_PATHWAYS_FULL_NETWORK	ERCC3 GTF2H4 XPA XRCC5 POLK	1.31e-04	120	58	5	M40049
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_RAS_UBIQUITINATION_BY_CUL3_COMPLEX	CUL3 LZTR1	2.47e-04	6	58	2	M47931
Pathway	WP_NUCLEOTIDE_EXCISION_REPAIR_IN_XERODERMA_PIGMENTOSUM	ERCC3 GTF2H4 XPA POLK	2.52e-04	75	58	4	M42538
Pathway	REACTOME_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR_TC_NER	ERCC3 GTF2H4 XPA POLK	2.52e-04	75	58	4	MM15316
Pathway	REACTOME_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR_TC_NER	ERCC3 GTF2H4 XPA POLK	2.65e-04	76	58	4	M27600
Pathway	REACTOME_FORMATION_OF_THE_EARLY_ELONGATION_COMPLEX	ERCC3 GTF2H4 NELFB	3.30e-04	33	58	3	MM14508
Pathway	REACTOME_FORMATION_OF_THE_EARLY_ELONGATION_COMPLEX	ERCC3 GTF2H4 NELFB	3.30e-04	33	58	3	M26919
Pathway	REACTOME_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR_GG_NER	ERCC3 GTF2H4 XPA POLK	3.72e-04	83	58	4	MM15305
Pathway	REACTOME_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR_GG_NER	ERCC3 GTF2H4 XPA POLK	3.90e-04	84	58	4	M27594
Pathway	REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER	ERCC3 GTF2H4 XPA	7.26e-04	43	58	3	M1005
Pathway	REACTOME_HIV_TRANSCRIPTION_ELONGATION	ERCC3 GTF2H4 NELFB	7.26e-04	43	58	3	M29569
Pathway	KEGG_NUCLEOTIDE_EXCISION_REPAIR	ERCC3 GTF2H4 XPA	7.77e-04	44	58	3	M18937
Pathway	WP_NUCLEOTIDE_EXCISION_REPAIR	ERCC3 GTF2H4 XPA	7.77e-04	44	58	3	M39847
Pathway	REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER	ERCC3 GTF2H4 XPA	8.30e-04	45	58	3	MM15302
Pathway	PID_P38_GAMMA_DELTA_PATHWAY	MAPK13 MAP2K3	8.93e-04	11	58	2	M209
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_DNA_REPAIR_GENES	ERCC3 GTF2H4 NELFB	9.42e-04	47	58	3	MM15328
Pathway	REACTOME_NUCLEOTIDE_EXCISION_REPAIR	ERCC3 GTF2H4 XPA POLK	1.01e-03	108	58	4	M7927
Pathway	REACTOME_NUCLEOTIDE_EXCISION_REPAIR	ERCC3 GTF2H4 XPA POLK	1.01e-03	108	58	4	MM15304
Pathway	REACTOME_FORMATION_OF_TC_NER_PRE_INCISION_COMPLEX	ERCC3 GTF2H4 XPA	1.20e-03	51	58	3	M27599
Pathway	REACTOME_FORMATION_OF_TC_NER_PRE_INCISION_COMPLEX	ERCC3 GTF2H4 XPA	1.20e-03	51	58	3	MM15315
Pathway	BIOCARTA_GATA3_PATHWAY	MAP2K3 MAF	1.47e-03	14	58	2	MM1402
Pathway	REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX	ERCC3 GTF2H4 NELFB	1.74e-03	58	58	3	M805
Pathway	REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX	ERCC3 GTF2H4 NELFB	1.82e-03	59	58	3	MM14504
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_DNA_REPAIR_GENES	ERCC3 GTF2H4 NELFB	2.10e-03	62	58	3	M27618
Pubmed	Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters.	OR51B5 OR51V1 OR51B4 OR51J1	3.47e-08	15	80	4	11121057
Pubmed	Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.	DOCK2 CUL3 ERCC3 LZTR1 YEATS4 CCT5 XPO6 XRCC5 MAP2K3	1.04e-06	454	80	9	33226137
Pubmed	Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.	SCN1A SCN8A	5.23e-06	2	80	2	37901435
Pubmed	An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.	SCN1A SCN8A	5.23e-06	2	80	2	26410685
Pubmed	Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck.	ERCC3 XPA	5.23e-06	2	80	2	29528139
Pubmed	MKK3 sustains cell proliferation and survival through p38DELTA MAPK activation in colorectal cancer.	MAPK13 MAP2K3	5.23e-06	2	80	2	31695024
Pubmed	Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma.	CHST5 CHST4	5.23e-06	2	80	2	12107080
Pubmed	Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy.	SCN1A SCN8A	5.23e-06	2	80	2	33411788
Pubmed	Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.	SCN1A SCN8A	5.23e-06	2	80	2	31943325
Pubmed	Systematic mutagenesis of TFIIH subunit p52/Tfb2 identifies residues required for XPB/Ssl2 subunit function and genetic interactions with TFB6.	ERCC3 GTF2H4	5.23e-06	2	80	2	36041630
Pubmed	Persistent Nav1.1 and Nav1.6 currents drive spinal locomotor functions through nonlinear dynamics.	SCN1A SCN8A	5.23e-06	2	80	2	37665666
Pubmed	The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.	SCN1A SCN8A	5.23e-06	2	80	2	17881658
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	IVNS1ABP ZFYVE28 CACNA1F FRY UBR4 SCN8A NELFB XRCC5 CFAP44 NDUFS2	7.35e-06	736	80	10	29676528
Pubmed	DNA damage recognition during nucleotide excision repair in mammalian cells.	ERCC3 GTF2H4 XPA	1.30e-05	20	80	3	10214908
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	RABL6 PHKB FRY CCT5 UBR4 BTBD10 SCN8A CHD8	1.40e-05	475	80	8	31040226
Pubmed	Distinct substrate specificities of human GlcNAc-6-sulfotransferases revealed by mass spectrometry-based sulfoglycomic analysis.	CHST5 CHST4	1.57e-05	3	80	2	30093410
Pubmed	Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate.	CHST5 CHST4	1.57e-05	3	80	2	12218059
Pubmed	Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex.	CUL3 LZTR1	1.57e-05	3	80	2	38453365
Pubmed	Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair.	ERCC3 GTF2H4	1.57e-05	3	80	2	17466626
Pubmed	Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.	SCN1A SCN8A	1.57e-05	3	80	2	32845893
Pubmed	Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.	SCN1A SCN8A	1.57e-05	3	80	2	28518218
Pubmed	Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.	SCN1A SCN8A	1.57e-05	3	80	2	24704313
Pubmed	Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis.	CHST5 CHST4	1.57e-05	3	80	2	12855678
Pubmed	The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels.	SCN1A SCN8A	1.57e-05	3	80	2	28117367
Pubmed	Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.	SCN1A SCN8A	1.57e-05	3	80	2	17928448
Pubmed	Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction.	SCN1A SCN8A	1.57e-05	3	80	2	26182346
Pubmed	De novo SCN1A, SCN8A, and CLCN2 mutations in childhood absence epilepsy.	SCN1A SCN8A	1.57e-05	3	80	2	31054517
Pubmed	Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue.	CHST5 CHST4	1.57e-05	3	80	2	10491328
Pubmed	An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.	ERCC3 XPA	1.57e-05	3	80	2	19114557
Pubmed	Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.	ERCC3 XPA XRCC5 POLK	1.89e-05	68	80	4	20496165
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	CUL3 ERCC3 CCT5 UBR4 NELFB CHD9 CHD8 XPA SIN3A XRCC5 MAP2K3	2.05e-05	1014	80	11	32416067
Pubmed	Variation within DNA repair pathway genes and risk of multiple sclerosis.	ERCC3 GTF2H4 XPA XRCC5	2.37e-05	72	80	4	20522537
Pubmed	Transforming growth factor-beta1 stimulates vascular endothelial growth factor 164 via mitogen-activated protein kinase kinase 3-p38alpha and p38delta mitogen-activated protein kinase-dependent pathway in murine mesangial cells.	MAPK13 MAP2K3	3.13e-05	4	80	2	15143069
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN1A SCN8A	3.13e-05	4	80	2	17537961
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN1A SCN8A	3.13e-05	4	80	2	35031483
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN1A SCN8A	3.13e-05	4	80	2	29578003
Pubmed	Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.	SCN1A SCN8A	3.13e-05	4	80	2	21156207
Pubmed	Mouse all-cone retina models of Cav1.4 synaptopathy.	CACNA1F NRL	3.13e-05	4	80	2	37181655
Pubmed	Biogenesis of lysosome-related organelles complex 3 (BLOC-3): a complex containing the Hermansky-Pudlak syndrome (HPS) proteins HPS1 and HPS4.	HPS4 HPS3	3.13e-05	4	80	2	12847290
Pubmed	ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion.	OSBPL11 OSBPL10	3.13e-05	4	80	2	22906437
Pubmed	Platelet alpha granules in BLOC-2 and BLOC-3 subtypes of Hermansky-Pudlak syndrome.	HPS4 HPS3	3.13e-05	4	80	2	17365864
Pubmed	Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for activation of p38alpha and p38delta MAPK isoforms by TGF-beta 1 in murine mesangial cells.	MAPK13 MAP2K3	3.13e-05	4	80	2	12374793
Pubmed	Models for discovery of targeted therapy in genetic epileptic encephalopathies.	SCN1A SCN8A	3.13e-05	4	80	2	28742937
Pubmed	Structural basis for group A trichothiodystrophy.	ERCC3 GTF2H4	3.13e-05	4	80	2	19172752
Pubmed	Quality control by DNA repair.	ERCC3 GTF2H4 XPA	3.68e-05	28	80	3	10583946
Pubmed	Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.	ERCC3 XPA XRCC5 POLK	4.35e-05	84	80	4	19237606
Pubmed	A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.	IVNS1ABP CUL3 LZTR1 BTBD10	5.00e-05	87	80	4	37495603
Pubmed	RIT1 oncoproteins escape LZTR1-mediated proteolysis.	CUL3 LZTR1	5.20e-05	5	80	2	30872527
Pubmed	Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer.	CUL3 MAF	5.20e-05	5	80	2	16785233
Pubmed	GlcNAc6ST3 is a keratan sulfate sulfotransferase for the protein-tyrosine phosphatase PTPRZ in the adult brain.	CHST5 CHST4	5.20e-05	5	80	2	30867513
Pubmed	Activation of the c-myc p1 promoter in Burkitt's lymphoma by the hs3 immunoglobulin heavy-chain gene enhancer.	SIN3A MAF	5.20e-05	5	80	2	17287852
Pubmed	Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations.	ERCC3 GTF2H4	5.20e-05	5	80	2	8612585
Pubmed	TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus.	ERCC3 GTF2H4	5.20e-05	5	80	2	14980221
Pubmed	MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation.	MAPK13 MAP2K3	5.20e-05	5	80	2	35971771
Pubmed	alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus.	ERCC3 XPA XRCC5	6.66e-05	34	80	3	16889989
Pubmed	Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.	CHST5 VAT1L MAF	7.27e-05	35	80	3	19844255
Pubmed	Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases.	FPR1 MAPK13	7.79e-05	6	80	2	22447027
Pubmed	KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination.	IVNS1ABP CUL3	7.79e-05	6	80	2	25619834
Pubmed	p52 Mediates XPB function within the transcription/repair factor TFIIH.	ERCC3 GTF2H4	7.79e-05	6	80	2	12080057
Pubmed	The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH.	ERCC3 GTF2H4	7.79e-05	6	80	2	28977422
Pubmed	Dominant Noonan syndrome-causing LZTR1 mutations specifically affect the Kelch domain substrate-recognition surface and enhance RAS-MAPK signaling.	CUL3 LZTR1	7.79e-05	6	80	2	30481304
Pubmed	LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases.	CUL3 LZTR1	7.79e-05	6	80	2	31337872
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN1A SCN8A	7.79e-05	6	80	2	23652591
Pubmed	Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades.	MAPK13 MAP2K3	7.79e-05	6	80	2	9841871
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZFYVE28 CHD8 VAT1L ANKH	8.94e-05	101	80	4	10997877
Pubmed	TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation.	XPA TG	1.09e-04	7	80	2	9214635
Pubmed	Murine leukemia virus spreading in mice impaired in the biogenesis of secretory lysosomes and Ca2+-regulated exocytosis.	HPS4 HPS3	1.09e-04	7	80	2	18629000
Pubmed	BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor.	HPS4 HPS3	1.09e-04	7	80	2	23084991
Pubmed	Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.	SCN1A SCN8A	1.09e-04	7	80	2	25818041
Pubmed	Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis.	MAPK13 MAP2K3	1.09e-04	7	80	2	23202732
Pubmed	Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family.	CHST5 CHST4	1.09e-04	7	80	2	11181564
Pubmed	Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes.	SCN1A SCN8A	1.09e-04	7	80	2	15272007
Pubmed	A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy.	ERCC3 XPA	1.09e-04	7	80	2	10447254
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PLCD3 CUL3 POGK SUPV3L1 OSBPL11 OSBPL10 CHD8 SIN3A	1.27e-04	650	80	8	38777146
Pubmed	Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH.	ERCC3 GTF2H4	1.45e-04	8	80	2	9118947
Pubmed	Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene.	CUL3 XRCC5	1.45e-04	8	80	2	20463177
Pubmed	Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH.	ERCC3 GTF2H4	1.86e-04	9	80	2	9130708
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN1A SCN8A	1.86e-04	9	80	2	16382098
Pubmed	Survival and lung pathology of mouse models of Hermansky-Pudlak syndrome and Chediak-Higashi syndrome.	HPS4 HPS3	1.86e-04	9	80	2	10193444
Pubmed	Xeroderma Pigmentosum	ERCC3 XPA	1.86e-04	9	80	2	20301571
Pubmed	ORP/Osh mediate cross-talk between ER-plasma membrane contact site components and plasma membrane SNAREs.	OSBPL11 OSBPL10	1.86e-04	9	80	2	32734583
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN1A SCN8A	1.86e-04	9	80	2	15746173
Pubmed	The Role of XPB/Ssl2 dsDNA Translocase Processivity in Transcription Start-site Scanning.	ERCC3 GTF2H4	1.86e-04	9	80	2	33453189
Pubmed	Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.	SCN1A SCN8A	1.86e-04	9	80	2	17884088
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	IVNS1ABP CUL3 ZFYVE28 CCT5 HPS4 CHD8 ANKH	2.21e-04	529	80	7	14621295
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	ERCC3 GTF2H4 YEATS4 NELFB CHD9 CHD8 NDUFS2	2.31e-04	533	80	7	30554943
Pubmed	Sulfation of the human immunodeficiency virus envelope glycoprotein.	CHST5 CHST4	2.32e-04	10	80	2	1433500
Pubmed	Hermansky-Pudlak syndrome protein complexes associate with phosphatidylinositol 4-kinase type II alpha in neuronal and non-neuronal cells.	HPS4 HPS3	2.32e-04	10	80	2	19010779
Pubmed	A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A.	ERCC3 GTF2H4	2.32e-04	10	80	2	15220921
Pubmed	Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH.	ERCC3 GTF2H4	2.32e-04	10	80	2	26340423
Pubmed	Melanosome morphologies in murine models of hermansky-pudlak syndrome reflect blocks in organelle development.	HPS4 HPS3	2.32e-04	10	80	2	12445206
Pubmed	Regulation of lens fiber cell differentiation by transcription factor c-Maf.	NRL MAF	2.32e-04	10	80	2	10383433
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	PHKB ERCC3 GTF2H4 YEATS4 SIN3A CPLANE1 MAPK13 USP27X MAP2K3	2.43e-04	910	80	9	36736316
Pubmed	Hermansky-Pudlak Syndrome	HPS4 HPS3	2.84e-04	11	80	2	20301464
Pubmed	The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.	MPP1 CUL3	2.84e-04	11	80	2	27621083
Pubmed	The OSBP-related protein family in humans.	OSBPL11 OSBPL10	2.84e-04	11	80	2	11483621
Pubmed	Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome.	ERCC3 XPA	2.84e-04	11	80	2	11259578
Pubmed	Three functional classes of transcriptional activation domain.	ERCC3 GTF2H4	2.84e-04	11	80	2	8628270
Pubmed	Tat activates human immunodeficiency virus type 1 transcriptional elongation independent of TFIIH kinase.	ERCC3 GTF2H4	2.84e-04	11	80	2	10082552
Pubmed	Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine.	CHST5 CHST4	2.84e-04	11	80	2	8419650
Cytoband	11p15.4	OR51B5 OR51V1 OR51J1 OR52B6	4.27e-04	200	80	4	11p15.4
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	OR51B5 BTBD10 OR51V1 OR51B4 OR51J1 OR52B6	4.66e-04	564	80	6	chr11p15
Cytoband	Ensembl 112 genes in cytogenetic band chr16q23	CHST5 VAT1L MAF	1.12e-03	116	80	3	chr16q23
GeneFamily	Olfactory receptors, family 51	OR51B5 OR51V1 OR51B4 OR51J1	1.35e-05	44	60	4	164
GeneFamily	WD repeat domain containing\|Xeroderma pigmentosum complementation groups\|Nucleotide excision repair	ERCC3 XPA	2.99e-04	8	60	2	1125
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN1A SCN8A	3.84e-04	9	60	2	1203
GeneFamily	Oxysterol binding proteins\|Pleckstrin homology domain containing	OSBPL11 OSBPL10	7.00e-04	12	60	2	670
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	IVNS1ABP LZTR1 BTBD10 ZBTB40	1.02e-03	134	60	4	861
GeneFamily	General transcription factors\|Xeroderma pigmentosum complementation groups\|DNA helicases\|ERCC excision repair associated	ERCC3 GTF2H4	3.09e-03	25	60	2	565
GeneFamily	Sulfotransferases, membrane bound	CHST5 CHST4	6.69e-03	37	60	2	763
Coexpression	GSE27786_LIN_NEG_VS_NEUTROPHIL_UP	MCM9 DPY19L4 CHD9 MIGA1 SLC43A3 ANKH RUSF1	2.60e-06	199	80	7	M4794
Disease	Mental Retardation, Psychosocial	RABL6 FRY SCN1A SCN8A ZBTB40 CHD8 SIN3A	7.37e-08	139	76	7	C0025363
Disease	Profound Mental Retardation	RABL6 FRY SCN1A SCN8A ZBTB40 CHD8 SIN3A	7.37e-08	139	76	7	C0020796
Disease	Mental deficiency	RABL6 FRY SCN1A SCN8A ZBTB40 CHD8 SIN3A	7.37e-08	139	76	7	C0917816
Disease	Intellectual Disability	RABL6 FRY SCN1A SCN8A ZBTB40 CHD8 XPA SIN3A USP27X	2.25e-06	447	76	9	C3714756
Disease	xeroderma pigmentosum (is_implicated_in)	ERCC3 XPA	9.75e-05	6	76	2	DOID:0050427 (is_implicated_in)
Disease	Hermansky-Pudlak syndrome (is_implicated_in)	HPS4 HPS3	1.36e-04	7	76	2	DOID:3753 (is_implicated_in)
Disease	CHARGE syndrome (implicated_via_orthology)	CHD9 CHD8	1.36e-04	7	76	2	DOID:0050834 (implicated_via_orthology)
Disease	Xeroderma pigmentosum	ERCC3 XPA	2.33e-04	9	76	2	cv:C0043346
Disease	Hermanski-Pudlak Syndrome	HPS4 HPS3	2.91e-04	10	76	2	C0079504
Disease	Hermansky-Pudlak syndrome	HPS4 HPS3	2.91e-04	10	76	2	cv:C0079504
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN1A SCN8A	2.91e-04	10	76	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN1A SCN8A	2.91e-04	10	76	2	DOID:0080422 (implicated_via_orthology)
Disease	Basal cell carcinoma	ERCC3 XPA	3.55e-04	11	76	2	C0007117
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN1A SCN8A	4.25e-04	12	76	2	DOID:0060170 (implicated_via_orthology)
Disease	platelet storage pool deficiency (implicated_via_orthology)	HPS4 HPS3	6.73e-04	15	76	2	DOID:2223 (implicated_via_orthology)
Disease	Autism Spectrum Disorders	SCN1A CHD8 SIN3A	1.39e-03	85	76	3	C1510586
Disease	hypertrophic cardiomyopathy (is_implicated_in)	LZTR1 NDUFS2	1.46e-03	22	76	2	DOID:11984 (is_implicated_in)
Disease	Neurodevelopmental Disorders	CUL3 SCN1A SCN8A	1.80e-03	93	76	3	C1535926
Disease	Dwarfism	SIN3A TG	1.89e-03	25	76	2	C0013336
Disease	Micronuclei, Chromosome-Defective	XPA POLK	2.04e-03	26	76	2	C1449861
Disease	Micronuclei, Genotoxicant-Induced	XPA POLK	2.04e-03	26	76	2	C1449862

Protein segments in the cluster

Peptide	Gene	Start	Entry
FPLEMAVFMREHLNY	ABCG4	446	Q9H172
EFYLEEMILPLMVAS	BTBD10	286	Q9BSF8
QDPDFSFLAARMNYM	CHD8	1951	Q9HCK8
MFEDDTFVYMIEPLE	ADAM23	221	O75077
YLAMPFATPMEAELA	CTAG1A	91	P78358
FMEKERMEYFLSTLP	ANKRD18B	936	A2A2Z9
YDYMELASMPFVTLD	CFAP44	111	Q96MT7
IAAQMLSFVMDDPDF	RABL6	561	Q3YEC7
LTQDMIDDYEPALMF	ZFYVE28	211	Q9HCC9
APFNYAMDILNMVFT	CACNA1F	1216	O60840
YFEAMFRSFMPEDGQ	LZTR1	691	Q8N653
PLAMEYVNDFDLMKF	MAF	16	O75444
MIPNGYLMFEDENFI	IVNS1ABP	1	Q9Y6Y0
MHSEFAQLPALYEMT	HPS4	636	Q9NQG7
PMYYFLAMLADTDLG	OR51B4	56	Q9Y5P0
PMYFFLAMLAATDLG	OR51B5	56	Q9H339
SPLLQAMMANAYLFF	OR51J1	271	Q9H342
QPMFYFLSMLALTDL	OR51V1	66	Q9H2C8
HEPMYIFLSMLASAD	OR52B6	76	Q8NGF0
FTEDDEKVMQMYLPF	PDE11A	351	Q9HCR9
SPLAMEYVNDFDLMK	NRL	6	P54845
EEDLRNLMFGDYMNP	DNAH12	2176	Q6ZR08
TRFLPMLMSFLVDDY	NELFB	371	Q8WX92
YDFYLVMPFMQTDLQ	MAPK13	101	O15264
MRMNYETVLSLEFPF	POGK	76	Q9P215
QALPYFDRLDYVSMM	NDUFS2	131	O75306
MTDPMMDFFDDANLF	CHD9	1	Q3L8U1
PTYMAEEMQEASLFF	GKN1	146	Q9NS71
ATIPIFFDMMLCEYQ	DOCK2	1106	Q92608
EISYFQFPGELLMRM	SLC1A7	46	O00341
MLPFSRFFNMEELIQ	CPLANE1	1331	Q9H799
EAPFLEMSAEFFQME	CUL3	206	Q13618
FPRLMTELMELQEFY	DPY19L4	546	Q7Z388
TDFHPLMDQFMNDYV	DNAAF9	1136	Q5TEA3
AFLYLAAFPFMDAMA	ANKH	131	Q9HCJ1
SAPLFMLDLYNAMTN	BMP5	76	P22003
LDYKSNFEPFFMMIA	GNS	216	P15586
AYRMLMDFEQLQPGD	MECR	171	Q9BV79
LPALQMFMRAQFDYD	MPP1	156	Q00013
KSDIPMDLFDFYEQM	ERCC3	241	P19447
MYPVEDFEASLQFMQ	FRY	281	Q5TBA9
TEMDPFYAENFMANT	CCDC168	2521	Q8NDH2
FLYISLADMFPEMNE	SLC39A14	436	Q15043
FARNAFTVLAMMDYP	DPP7	261	Q9UHL4
IECEFPIFFLYMMID	PHKB	361	Q93100
MYADFMSHPDLFIAI	OSBPL11	401	Q9BXB4
AERMSYLELMEHPFF	MAP2K3	311	P46734
FGDMDIFLPATMAYD	OR1P1	121	Q8NH06
VMTEEEFALKVFPMY	MROH2A	246	A6NES4
NMEIGEYFNMFPSEV	MCM9	51	Q9NXL9
PENLYLMGMELFEEA	MIGA1	206	Q8NAN2
LNDVAMFLEIMAPVY	RUSF1	171	Q96GQ5
EEFMDPATFINMYNR	TEX47	221	Q8TBZ9
PFSKAFRDQMYIIEM	HPS3	116	Q969F9
LNPMLYVFMGQDFRE	FPR1	296	P21462
DLEMLAPYISMDDDF	HIF3A	486	Q9Y2N7
MDVDVEDYYPAFLDM	SIN3A	951	Q96ST3
YAMRAFADALEVIPM	CCT5	446	P48643
LQNDPFYVNVMFMLA	SLC43A3	451	Q8NBI5
NFDFDQMYPVALVML	SYAP1	161	Q96A49
LSYRFMDMFPDASLI	SUPV3L1	641	Q8IYB8
RSLLEMYADFMAHPD	OSBPL10	426	Q9BXB5
FTAEMFLKIIAMDPY	SCN1A	811	P35498
VFLCDMSVFDAYMEP	CHST4	101	Q8NCG5
IFLCDMDVFDAYMPQ	CHST5	121	Q9GZS9
EEMFYQLSNMLPQIF	C12orf4	526	Q9NQ89
FSEMLYRFPNMVVAQ	GTF2H4	331	Q92759
YISFPLELDMTPFMA	USP27X	326	A6NNY8
FMMYLLSPEGAALDN	PLCD3	316	Q8N3E9
YVIDNYFPEMERMDL	PLEKHG4B	826	Q96PX9
VKEILADYDPNFMAM	POLK	181	Q9UBT6
FTAEMFLKLIAMDPY	SCN8A	796	Q9UQD0
FPMNFVTAYVMLFEV	VAT1L	161	Q9HCJ6
EFMDSYLMNHFDLPT	XPA	111	P23025
PMEFEEYLLRMFQQT	XPO6	326	Q96QU8
SEFYDEMIFQDPTAM	YEATS4	136	O95619
SFAPLVLDMLNFLMD	UBR4	1806	Q5T4S7
DMMIFDLVHSYNRFP	TG	201	P01266
LMRAYMQEPLFVEFA	ZNHIT3	126	Q15649
YVQLPFMEDLRQYMF	XRCC5	421	P13010
VSPEEFALLLEMMYT	ZBTB40	66	Q9NUA8