Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmolecular condensate scaffold activity

UBQLN2 NUP98 DAXX WNK1 CAPRIN1

8.80e-06421345GO:0140693
GeneOntologyMolecularFunctioncytoskeletal protein binding

KIF21B RAB25 DCDC1 REEP1 SYNE1 SPTA1 NUMA1 DAXX ADCY8 SMTN TTBK1 SYNE3 NDC80 MYLIP CLTC SCNN1A DIAPH2 UTRN PALLD CAP2

4.43e-05109913420GO:0008092
GeneOntologyCellularComponentnuclear protein-containing complex

PARP11 NRIP1 EAF2 SYNE1 MED31 NUP98 RRP8 CREBZF NEUROD1 SYNE3 CDC40 CLTC PWP2 COPS4 CSTF2 CPSF1 PRKDC TAF4 ASCC3 MED17 LSM10 CSTF2T

7.06e-05137713522GO:0140513
DomainUbiquilin

UBQLN2 UBQLN1 UBQLN3

7.11e-0661343IPR015496
DomainSpectrin

SYNE1 SPTA1 SYNE3 UTRN

2.02e-05231344PF00435
DomainL_dom-like

ERBB3 NLRX1 LRRC10B LRRK1 LRG1 LRRC55 IGF1R NOD1 PXDNL SLITRK5 LRRC15

2.50e-0532813411IPR032675
DomainSTI1

UBQLN2 UBQLN1 UBQLN3

4.18e-05101343SM00727
DomainSTI1_HS-bd

UBQLN2 UBQLN1 UBQLN3

4.18e-05101343IPR006636
DomainTPR-like_helical_dom

NRDE2 TTC39C TTC19 TRANK1 CLTC COPS4 PRKDC DNAJC3 FKBP5

4.74e-052331349IPR011990
DomainCSTF2_hinge

CSTF2 CSTF2T

5.11e-0521342PF14327
DomainCSTF_C

CSTF2 CSTF2T

5.11e-0521342PF14304
DomainCSTF2_hinge

CSTF2 CSTF2T

5.11e-0521342IPR025742
DomainUbiquilin-1/2

UBQLN2 UBQLN1

5.11e-0521342IPR028430
DomainCSTF_C

CSTF2 CSTF2T

5.11e-0521342IPR026896
DomainSpectrin_repeat

SYNE1 SPTA1 SYNE3 UTRN

5.23e-05291344IPR002017
DomainUbiquitin-rel_dom

UBQLN2 UBQLN1 PTPN13 RAPGEF3 UBQLN3 MYLIP TP53BP2 PLCE1

5.52e-051841348IPR029071
DomainSPEC

SYNE1 SPTA1 SYNE3 UTRN

7.79e-05321344SM00150
DomainSpectrin/alpha-actinin

SYNE1 SPTA1 SYNE3 UTRN

7.79e-05321344IPR018159
DomainLeu-rich_rpt

NLRX1 LRRC10B LRRK1 LRG1 LRRC55 NOD1 PXDNL SLITRK5 LRRC15

1.50e-042711349IPR001611
DomainTPR_REGION

TTC39C DNAH2 TTC19 TRANK1 PRKDC DNAJC3 FKBP5

1.90e-041651347PS50293
DomainTPR

TTC39C DNAH2 TTC19 TRANK1 PRKDC DNAJC3 FKBP5

1.90e-041651347PS50005
DomainLRR_TYP

LRRC10B LRRK1 LRG1 LRRC55 PXDNL SLITRK5 LRRC15

2.91e-041771347SM00369
DomainLeu-rich_rpt_typical-subtyp

LRRC10B LRRK1 LRG1 LRRC55 PXDNL SLITRK5 LRRC15

2.91e-041771347IPR003591
DomainKASH

SYNE1 SYNE3

3.04e-0441342IPR012315
DomainNeurogenic_DUF

NEUROD1 NEUROD2

3.04e-0441342IPR022575
DomainKASH

SYNE1 SYNE3

3.04e-0441342PS51049
DomainKASH

SYNE1 SYNE3

3.04e-0441342SM01249
DomainKASH

SYNE1 SYNE3

3.04e-0441342PF10541
DomainNeuro_bHLH

NEUROD1 NEUROD2

3.04e-0441342PF12533
DomainTF_bHLH_NeuroD

NEUROD1 NEUROD2

3.04e-0441342IPR016637
DomainWnt

WNT1 WNT2 WNT8A

3.22e-04191343IPR005817
Domain6-PGluconate_DH_C-like

UBQLN2 UBQLN1 UBQLN3

3.22e-04191343IPR008927
DomainWNT1

WNT1 WNT2 WNT8A

3.22e-04191343PS00246
DomainWnt_CS

WNT1 WNT2 WNT8A

3.22e-04191343IPR018161
Domainwnt

WNT1 WNT2 WNT8A

3.22e-04191343PF00110
DomainWNT1

WNT1 WNT2 WNT8A

3.22e-04191343SM00097
Domain-

ANKRD26 LRRK1 TRANK1 CLPB KANK3 NFKBIE ANKRD52 TP53BP2

4.27e-0424813481.25.40.20
DomainANK

ANKRD26 LRRK1 TRANK1 CLPB KANK3 NFKBIE ANKRD52 TP53BP2

4.63e-042511348SM00248
DomainCys-rich_flank_reg_C

LRG1 LRRC55 PXDNL SLITRK5 LRRC15

4.76e-04901345IPR000483
DomainLRRCT

LRG1 LRRC55 PXDNL SLITRK5 LRRC15

4.76e-04901345SM00082
DomainANK_REPEAT

ANKRD26 LRRK1 TRANK1 CLPB KANK3 NFKBIE ANKRD52 TP53BP2

4.87e-042531348PS50088
DomainAnkyrin_rpt-contain_dom

ANKRD26 LRRK1 TRANK1 CLPB KANK3 NFKBIE ANKRD52 TP53BP2

5.00e-042541348IPR020683
DomainANK_REP_REGION

ANKRD26 LRRK1 TRANK1 CLPB KANK3 NFKBIE ANKRD52 TP53BP2

5.00e-042541348PS50297
Domain-

NLRX1 LRRC10B LRRK1 LRG1 LRRC55 NOD1 PXDNL SLITRK5 LRRC15

5.21e-0432113493.80.10.10
DomainAnkyrin_rpt

ANKRD26 LRRK1 TRANK1 CLPB KANK3 NFKBIE ANKRD52 TP53BP2

6.13e-042621348IPR002110
DomainLRR

LRRC10B LRRK1 LRG1 LRRC55 PXDNL SLITRK5 LRRC15

6.25e-042011347PS51450
Domain-

NRDE2 TTC39C TTC19 TRANK1 CLTC DNAJC3 FKBP5

7.43e-0420713471.25.40.10
DomainLiprin

PPFIA4 PPFIA1

7.52e-0461342IPR029515
DomainAnk_2

ANKRD26 LRRK1 CLPB KANK3 NFKBIE ANKRD52 TP53BP2

9.28e-042151347PF12796
DomainLRR_1

LRRC10B LRRK1 LRG1 LRRC55 PXDNL SLITRK5 LRRC15

1.03e-032191347PF00560
DomainRecep_L_domain

ERBB3 IGF1R

1.05e-0371342PF01030
DomainFurin-like

ERBB3 IGF1R

1.05e-0371342PF00757
DomainRcpt_L-dom

ERBB3 IGF1R

1.05e-0371342IPR000494
DomainFurin-like_Cys-rich_dom

ERBB3 IGF1R

1.05e-0371342IPR006211
Domain-

ERBB3 IGF1R

1.05e-03713423.80.20.20
DomainUBA

UBQLN2 UBQLN1 UBQLN3

1.27e-03301343SM00165
DomainAnk

ANKRD26 LRRK1 CLPB KANK3 NFKBIE ANKRD52 TP53BP2

1.30e-032281347PF00023
DomainDHC_N1

DYNC2H1 DNAH2

1.39e-0381342PF08385
DomainDynein_heavy_dom-1

DYNC2H1 DNAH2

1.39e-0381342IPR013594
DomainLRR_8

LRRC10B LRG1 LRRC55 PXDNL SLITRK5 LRRC15

1.47e-031711346PF13855
DomainKinase-like_dom

TNIK ERBB3 LRRK1 ARHGAP35 WNK1 CHUK PTPN13 TTBK1 IGF1R PRKCB PRKDC

1.84e-0354213411IPR011009
DomainUBA

UBQLN2 UBQLN1 UBQLN3

2.17e-03361343PF00627
DomainUBIQUITIN_1

UBQLN2 UBQLN1 UBQLN3

2.35e-03371343PS00299
DomainARM-type_fold

DNAJC13 UBQLN2 UBQLN1 NCAPG CLTC DIAPH2 PKP1 PRKDC

3.13e-033391348IPR016024
DomainUBQ

UBQLN2 UBQLN1 UBQLN3

3.61e-03431343SM00213
DomainUBA

UBQLN2 UBQLN1 UBQLN3

3.86e-03441343IPR015940
DomainDynein_heavy_chain_D4_dom

DYNC2H1 DNAH2

4.39e-03141342IPR024317
DomainDynein_HC_stalk

DYNC2H1 DNAH2

4.39e-03141342IPR024743
DomainDynein_heavy_dom-2

DYNC2H1 DNAH2

4.39e-03141342IPR013602
DomainDHC_N2

DYNC2H1 DNAH2

4.39e-03141342PF08393
DomainATPase_dyneun-rel_AAA

DYNC2H1 DNAH2

4.39e-03141342IPR011704
DomainMT

DYNC2H1 DNAH2

4.39e-03141342PF12777
DomainAAA_8

DYNC2H1 DNAH2

4.39e-03141342PF12780
DomainAAA_5

DYNC2H1 DNAH2

4.39e-03141342PF07728
DomainTPR-contain_dom

TTC19 TRANK1 PRKDC DNAJC3 FKBP5

4.55e-031501345IPR013026
Domainubiquitin

UBQLN2 UBQLN1 UBQLN3

4.65e-03471343PF00240
DomainUBA

UBQLN2 UBQLN1 UBQLN3

4.65e-03471343PS50030
DomainDHC_fam

DYNC2H1 DNAH2

5.05e-03151342IPR026983
DomainDynein_heavy

DYNC2H1 DNAH2

5.05e-03151342PF03028
DomainSpectrin_alpha_SH3

SPTA1 TP53BP2

5.05e-03151342IPR013315
DomainDynein_heavy_dom

DYNC2H1 DNAH2

5.05e-03151342IPR004273
DomainLRRNT

LRRC55 PXDNL SLITRK5 LRRC15

5.44e-03981344IPR000372
DomainLRRNT

LRRC55 PXDNL SLITRK5 LRRC15

5.44e-03981344SM00013
DomainUBIQUITIN_2

UBQLN2 UBQLN1 UBQLN3

6.86e-03541343PS50053
PathwayBIOCARTA_HIVNEF_PATHWAY

NUMA1 CASP9 DAXX CHUK PRKDC

4.23e-0556985M13968
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA

CSTF2 CPSF1 LSM10 CSTF2T

4.56e-0529984M783
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA

CSTF2 CPSF1 LSM10 CSTF2T

4.56e-0529984MM15444
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION_TERMINATION

CDC40 CSTF2 CPSF1 LSM10 CSTF2T

6.93e-0562985MM15426
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION_TERMINATION

CDC40 CSTF2 CPSF1 LSM10 CSTF2T

1.01e-0467985M27694
PathwayWP_FAS_PATHWAY_AND_STRESS_INDUCTION_OF_HSP_REGULATION

CASP9 DAXX PTPN13 PRKDC

1.09e-0436984MM15967
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_ACYLATION

WNT1 WNT2 WNT8A

2.91e-0419983M47836
PathwayREACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS

CSTF2 CPSF1 CSTF2T

3.41e-0420983M497
PathwayREACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES

PPFIA4 PPFIA1 SLITRK5

3.41e-0420983M27290
PathwayREACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS

CSTF2 CPSF1 CSTF2T

3.41e-0420983MM15469
PathwayREACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES

PPFIA4 PPFIA1 SLITRK5

3.41e-0420983MM14991
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

KIF21B NRIP1 PPFIA1 NUMA1 CASP9 RRP8 TTC19 IGF1R TRANK1 DIAPH2 COPS4 CSTF2 CPSF1 TAF4 ASCC3 CDH7

1.29e-104971361636774506
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

HAUS5 NUMA1 ARHGAP35 PTPN13 NCAPG NFKBIE CLTC CSTF2 PRKDC TAF4 ASCC3 MED17 PALLD CSTF2T TP53BP2

4.67e-095491361538280479
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

TNIK PPFIA1 ARHGAP35 PTPN13 ASCC3 UTRN CAPRIN1 PALLD TP53BP2

1.49e-07209136936779422
Pubmed

Expression pattern of mouse sFRP-1 and mWnt-8 gene during heart morphogenesis.

WNT1 WNT2 WNT8A

2.33e-074136310640709
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DYNC2H1 PPFIA4 ANKRD26 ARHGEF18 ARHGAP35 WNK1 PIKFYVE TTBK1 SLITRK5 PALLD CSTF2T UNC80

5.97e-074931361215368895
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

NRIP1 ERBB3 UBQLN2 UBQLN1 GTPBP6 SYNE1 BTBD2 CREBZF CHUK PTPN13 NEUROD2 CLPB CLTC COPS4 PRKDC USP54 UTRN CAPRIN1 CAP2

6.70e-0712851361935914814
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TNIK KIF21B DNAJC13 SYNE1 PPFIA1 NUMA1 ARHGEF18 GRM3 CLTC DIAPH2 PRKCB TAF4 CAPRIN1 CAP2 TP53BP2 LRRC15

1.24e-069631361628671696
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

NUMA1 NUP98 DAXX RRP8 CLPB CLTC PWP2 USP54 ASCC3 MED17 CAPRIN1

1.39e-064401361134244565
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

TNIK DNAJC13 DYNC2H1 SYNE1 PPFIA1 ANKRD26 RRP8 PTPN13 NCAPG SYNE3 RPAP1 CLPB CLTC PWP2 COPS4 ASCC3 ANKRD52 DNAJC3 CAPRIN1 FKBP5

1.43e-0614871362033957083
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

TNIK SYNE1 PPFIA1 ARHGEF18 GRM3 CLTC PKP1 PRKCB TP53BP2

1.77e-06281136928706196
Pubmed

FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.

NUP98 RRP8 NCAPG CLPB COPS4 CPSF1 FBXO32 ASCC3

2.01e-06212136833462405
Pubmed

The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation.

CSTF2 CPSF1 CSTF2T

3.23e-06813637590244
Pubmed

Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.

CSTF2 CPSF1 CSTF2T

4.83e-069136314749727
Pubmed

Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.

HAUS5 ANKRD26 ARHGAP35 PTPN13 ASCC3 PALLD TP53BP2

4.87e-06169136731462741
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

UBQLN2 UBQLN1 NUMA1 NUP98 ARHGEF18 WNK1 CDC40 UBQLN3 CLTC TP53BP2

8.00e-064301361035044719
Pubmed

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

DNAJC13 NUP98 RRP8 FAAH SYNE3 PWP2 PRKDC ASCC3 CSTF2T

8.27e-06340136929478914
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

OR11L1 DNAJC13 RAB25 DYNC2H1 SLC44A2 LAP3 ACE2 PTPN13 RAPGEF3 CLTC MMRN2 SCPEP1 UTRN FKBP5 LRRC15

1.12e-0510161361519056867
Pubmed

A family of splice variants of CstF-64 expressed in vertebrate nervous systems.

CSTF2 CSTF2T

1.52e-052136219284619
Pubmed

Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein.

CSTF2 CSTF2T

1.52e-052136212773396
Pubmed

Dual targeting of IGF-1R and ErbB3 as a potential therapeutic regimen for ovarian cancer.

ERBB3 IGF1R

1.52e-052136231728045
Pubmed

Polyadenylation proteins CstF-64 and tauCstF-64 exhibit differential binding affinities for RNA polymers.

CSTF2 CSTF2T

1.52e-052136217029590
Pubmed

LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein.

ACE2 LRRC15

1.52e-052136236735681
Pubmed

The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion.

NEUROD1 NEUROD2

1.52e-052136211900979
Pubmed

LRRC15 inhibits SARS-CoV-2 cellular entry in trans.

ACE2 LRRC15

1.52e-052136236228039
Pubmed

A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities.

UBQLN2 UBQLN1

1.52e-052136229247619
Pubmed

Towards a molecular understanding of the overlapping and distinct roles of UBQLN1 and UBQLN2 in lung cancer progression and metastasis.

UBQLN2 UBQLN1

1.52e-052136235063704
Pubmed

Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs.

ACE2 LRRC15

1.52e-052136236757924
Pubmed

Cytoskeletal interactions at the nuclear envelope mediated by nesprins.

SYNE1 SYNE3

1.52e-052136222518138
Pubmed

Overexpression of the CstF-64 and CPSF-160 polyadenylation protein messenger RNAs in mouse male germ cells.

CSTF2 CPSF1

1.52e-052136211369601
Pubmed

Overlapping and distinct functions of CstF64 and CstF64τ in mammalian mRNA 3' processing.

CSTF2 CSTF2T

1.52e-052136224149845
Pubmed

IGF1R inhibition in mammary epithelia promotes canonical Wnt signaling and Wnt1-driven tumors.

WNT1 IGF1R

1.52e-052136225092896
Pubmed

Developmental distribution of the polyadenylation protein CstF-64 and the variant tauCstF-64 in mouse and rat testis.

CSTF2 CSTF2T

1.52e-052136214681198
Pubmed

IGF-1R and ErbB3/HER3 contribute to enhanced proliferation and carcinogenesis in trastuzumab-resistant ovarian cancer model.

ERBB3 IGF1R

1.52e-052136223792093
Pubmed

Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts.

WNT1 WNT2

1.52e-05213629652750
Pubmed

Elevated levels of the 64-kDa cleavage stimulatory factor (CstF-64) in lipopolysaccharide-stimulated macrophages influence gene expression and induce alternative poly(A) site selection.

CSTF2 CSTF2T

1.52e-052136216207706
Pubmed

NeuroD2 controls inhibitory circuit formation in the molecular layer of the cerebellum.

NEUROD1 NEUROD2

1.52e-052136230723302
Pubmed

MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors.

ERBB3 IGF1R

1.52e-052136224282274
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

DNAJC13 NUMA1 CLTC CPSF1 PRKDC USP54 ASCC3

1.56e-05202136724639526
Pubmed

Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.

BRPF3 NDC80 CLTC COPS4 CSTF2 PRKCB MED17 CSTF2T

1.67e-05283136828533407
Pubmed

Roles of Wnt8a during formation and patterning of the mouse inner ear.

WNT1 WNT8A NEUROD1

2.06e-0514136323041177
Pubmed

Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.

TRIM64 CHUK TRIM64B

2.57e-0515136319703589
Pubmed

Expression patterns of Wnt genes in mouse gut development.

WNT1 WNT2 WNT8A

2.57e-0515136311429295
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

NRIP1 SYNE1 ANKRD26 WNK1 TTC19 CLTC FBXO32 UTRN PALLD PLCE1

2.77e-054971361023414517
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

NRIP1 UBQLN2 UBQLN1 PPFIA4 PPFIA1 WNK1 TTC19 CSTF2 USP54 CSTF2T TP53BP2

2.89e-056081361116713569
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

UBQLN1 NUMA1 WNK1 LAP3 COPS4 CSTF2 CAPRIN1 PALLD CSTF2T

2.92e-05399136935987950
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

GTPBP6 NLRX1 TBC1D25 LRRK1 ARHGAP35 WNK1 PIKFYVE IGF1R SYNE3 RPAP1 KANK3 DIAPH2 CPSF1 PRKDC LSM10

2.96e-0511051361535748872
Pubmed

Regulatory pathway analysis by high-throughput in situ hybridization.

WNT1 GRM3 ADCY8 NEUROD1 SAMD3

3.02e-0591136517953485
Pubmed

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

NUP98 CHUK NDC80 CLTC COPS4 PRKCB PRKDC CAPRIN1 FKBP5

3.04e-05401136925852190
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

RAB25 PCDHB14 DNAH2 NEUROD2 RPAP1 CLTC CSTF2 CPSF1 PRKCB PRKDC SAMD3 UTRN

3.43e-057361361229676528
Pubmed

Proximity labeling reveals dynamic changes in the SQSTM1 protein network.

DNAJC13 ARHGAP35 CHUK CLPB USP54 ASCC3 PALLD TP53BP2

4.17e-05322136839098523
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

NRIP1 DNAJC13 PPFIA1 PTPN13 ASCC3 ANKRD52 UTRN CSTF2T TP53BP2

4.19e-05418136934709266
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

PARP11 DYNC2H1 NUP98 RRP8 BTBD2 CLPB PWP2 COPS4 PKP1 ASCC3 ANKRD52 UTRN FKBP5 LRRC15

4.20e-0510051361419615732
Pubmed

ERBB3-induced furin promotes the progression and metastasis of ovarian cancer via the IGF1R/STAT3 signaling axis.

ERBB3 IGF1R

4.54e-053136232029900
Pubmed

A new PKCα/β/TBX3/E-cadherin pathway is involved in PLCε-regulated invasion and migration in human bladder cancer cells.

PRKCB PLCE1

4.54e-053136224316392
Pubmed

Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.

RAPGEF3 PLCE1

4.54e-053136218957419
Pubmed

EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.

RAPGEF3 PRKDC

4.54e-053136218728186
Pubmed

Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin.

ERBB3 IGF1R

4.54e-053136220103628
Pubmed

Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy.

UBQLN2 UBQLN1

4.54e-053136220529957
Pubmed

Induction of pancreatic islet cell differentiation by the neurogenin-neuroD cascade.

NEUROD1 NEUROD2

4.54e-053136217924961
Pubmed

DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties.

CHUK PRKDC

4.54e-05313629632806
Pubmed

Extracellular modulation of the Hedgehog, Wnt and TGF-beta signalling pathways during embryonic development.

WNT1 WNT2

4.54e-053136210449357
Pubmed

The RNA 3' cleavage factors CstF 64 kDa and CPSF 100 kDa are concentrated in nuclear domains closely associated with coiled bodies and newly synthesized RNA.

CSTF2 CPSF1

4.54e-05313628654386
Pubmed

The Epac-Phospholipase Cε Pathway Regulates Endocannabinoid Signaling and Cocaine-Induced Disinhibition of Ventral Tegmental Area Dopamine Neurons.

RAPGEF3 PLCE1

4.54e-053136228209735
Pubmed

Nuclear IGF1R interacts with NuMA and regulates 53BP1‑dependent DNA double‑strand break repair in colorectal cancer.

NUMA1 IGF1R

4.54e-053136234165167
Pubmed

Ubiquitin receptor proteins hHR23a and hPLIC2 interact.

UBQLN2 UBQLN1

4.54e-053136217098253
Pubmed

Conserved region I of human coactivator TAF4 binds to a short hydrophobic motif present in transcriptional regulators.

CREBZF TAF4

4.54e-053136217483474
Pubmed

erbB3 recruitment of insulin receptor substrate 1 modulates insulin-like growth factor receptor signalling in oestrogen receptor-positive breast cancer cell lines.

ERBB3 IGF1R

4.54e-053136221939528
Pubmed

Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke.

RAPGEF3 PLCE1

4.54e-053136225103224
Pubmed

NeuroD1 is an upstream regulator of NSCL1.

NEUROD1 NEUROD2

4.54e-053136222310718
Pubmed

NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family.

NEUROD1 NEUROD2

4.54e-05313628816493
Pubmed

Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension.

WNK1 SCNN1A

4.54e-053136220921400
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

GTPBP6 MED31 NUMA1 DAXX PTPN13 CLTC PWP2 TAF4 MED17 CAP2

4.98e-055331361030554943
Pubmed

Coronary Artery Formation Is Driven by Localized Expression of R-spondin3.

WNT1 WNT2 WNT8A

5.41e-0519136328834739
Pubmed

Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis.

WNT1 WNT2 WNT8A

5.41e-0519136311520664
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

NUMA1 NUP98 RRP8 CLTC PWP2 CPSF1 PRKDC ASCC3 ANKRD52 UTRN CAPRIN1

5.50e-056531361122586326
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

DNAJC13 NUMA1 NUP98 DAXX ARHGAP35 SMTN RPAP1 CLTC CPSF1 PRKDC FKBP5 CSTF2T

5.56e-057741361215302935
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

PPFIA1 ANKRD26 WNK1 PTPN13 PRKDC USP54 ANKRD52 UTRN TP53BP2

6.89e-05446136924255178
Pubmed

Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis.

WNT1 WNT2 WNT8A

7.39e-0521136317943183
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

NRIP1 DNAJC13 RAB25 GTPBP6 ARHGEF18 ARHGAP35 DENND2B TTC19 PTPN13 IGF1R SCNN1A TAF4 UTRN DNAJC3 FKBP5 CAP2 PDZD2

7.44e-0514891361728611215
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

DNAJC13 NUMA1 SMTN ACSL1 NCAPG CDC40 CLTC PKP1 CPSF1 PRKDC ASCC3 ANKRD52 UTRN CAPRIN1 PALLD TP53BP2

8.19e-0513531361629467282
Pubmed

Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis.

NUMA1 PRKDC

9.06e-05413629586635
Pubmed

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV.

PIKFYVE ACE2

9.06e-054136232221306
Pubmed

Mdm2-mediated ubiquitination of PKCβII in the nucleus mediates clathrin-mediated endocytic activity.

CLTC PRKCB

9.06e-054136231634457
Pubmed

UBQLN2 undergoes a reversible temperature-induced conformational switch that regulates binding with HSPA1B: ALS/FTD mutations cripple the switch but do not destroy HSPA1B binding.

UBQLN2 UBQLN1

9.06e-054136236423739
Pubmed

Additive impact of HER2-/PTK6-RNAi on interactions with HER3 or IGF-1R leads to reduced breast cancer progression in vivo.

ERBB3 IGF1R

9.06e-054136225241146
Pubmed

Herp enhances ER-associated protein degradation by recruiting ubiquilins.

UBQLN2 UBQLN1

9.06e-054136218307982
Pubmed

Prognostic Significance of Wnt1, Wnt2, E-Cadherin, and β-catenin Expression in Operable Non-small Cell Lung Cancer.

WNT1 WNT2

9.06e-054136234666560
Pubmed

A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis.

CASP9 NOD1

9.06e-054136211113115
Pubmed

The gene for a variant form of the polyadenylation protein CstF-64 is on chromosome 19 and is expressed in pachytene spermatocytes in mice.

CSTF2 CSTF2T

9.06e-054136211113135
Pubmed

Dimerization of ubiquilin is dependent upon the central region of the protein: evidence that the monomer, but not the dimer, is involved in binding presenilins.

UBQLN2 UBQLN1

9.06e-054136216813565
Pubmed

Regulation of insulin-like growth factor receptors by Ubiquilin1.

UBQLN1 IGF1R

9.06e-054136229054976
Pubmed

mTOR kinase inhibition disrupts neuregulin 1-ERBB3 autocrine signaling and sensitizes NF2-deficient meningioma cellular models to IGF1R inhibition.

ERBB3 IGF1R

9.06e-054136233273014
Pubmed

Silencing of ErbB3/ErbB2 signaling by immunoglobulin-like Necl-2.

ERBB3 PTPN13

9.06e-054136219561085
Pubmed

Mammalian sperm head formation involves different polarization of two novel LINC complexes.

SYNE1 SYNE3

9.06e-054136220711465
Pubmed

Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha.

CHUK PRKCB

9.06e-054136212070292
Pubmed

NeuroD factors regulate cell fate and neurite stratification in the developing retina.

NEUROD1 NEUROD2

9.06e-054136221593321
Pubmed

Functional genetic approach identifies MET, HER3, IGF1R, INSR pathways as determinants of lapatinib unresponsiveness in HER2-positive gastric cancer.

ERBB3 IGF1R

9.06e-054136224973425
Pubmed

E6AP AZUL interaction with UBQLN1/2 in cells, condensates, and an AlphaFold-NMR integrated structure.

UBQLN2 UBQLN1

9.06e-054136236827983
Pubmed

Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling.

WNT1 WNT2

9.06e-054136210347172
Pubmed

Rae1 interaction with NuMA is required for bipolar spindle formation.

NUMA1 NUP98

9.06e-054136217172455
InteractionFBXO22 interactions

KIF21B NRIP1 PPFIA1 NUMA1 CASP9 RRP8 TTC19 IGF1R TRANK1 DIAPH2 COPS4 CSTF2 CPSF1 TAF4 ASCC3 CDH7

5.08e-0754013216int:FBXO22
InteractionAGAP2 interactions

TNIK SYNE1 PPFIA1 ARHGEF18 GRM3 CLTC PKP1 PRKCB TP53BP2

1.02e-052101329int:AGAP2
InteractionBAG2 interactions

TNIK BRPF3 DNAJC13 HAUS5 DNAH2 LRRK1 ARHGAP35 WNK1 RPAP1 CLTC PRKCB ASCC3 PALLD CSTF2T TP53BP2

1.43e-0562213215int:BAG2
InteractionTOLLIP interactions

TNIK UBQLN2 GTPBP6 PPFIA1 WNK1 ACE2 CLTC COPS4 PRKDC USP54 PALLD

2.43e-0535813211int:TOLLIP
GeneFamilyUbiquilin family

UBQLN2 UBQLN1 UBQLN3

1.22e-065913783
GeneFamilyWnt family|Endogenous ligands

WNT1 WNT2 WNT8A

1.13e-0419913360
GeneFamilySpectrin repeat containing nuclear envelope family

SYNE1 SYNE3

1.49e-0449121252
GeneFamilyAnkyrin repeat domain containing

ANKRD26 TRANK1 CLPB KANK3 NFKBIE ANKRD52 TP53BP2

2.20e-04242917403
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

TTC39C TTC19 TRANK1 DNAJC3 FKBP5

2.87e-04115915769
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

NRIP1 DNAJC13 PPFIA1 PEX3 NUP98 ARHGAP35 DENND2B PIKFYVE PTPN13 IGF1R NDC80 TAF4 ASCC3 CAP2 TP53BP2 PLCE1

8.96e-0685613516M4500
CoexpressionGSE16450_IMMATURE_VS_MATURE_NEURON_CELL_LINE_12H_IFNA_STIM_UP

NRIP1 SYNE1 ARHGEF18 DAXX PTPN13 NOD1 MYLIP UTRN

9.67e-062001358M7430
CoexpressionBROWNE_HCMV_INFECTION_20HR_DN

SYNE1 DENND2B PTPN13 DIAPH2 CAP2 LRRC15

1.50e-051021356M5601
CoexpressionBROWNE_HCMV_INFECTION_14HR_DN

SYNE1 NUMA1 DENND2B NEUROD1 NDC80 DIAPH2 SLITRK5 CPSF1 CAP2

2.03e-052901359M13251
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

NRIP1 DNAJC13 PPFIA1 PEX3 NUP98 PIKFYVE NDC80 TAF4 ASCC3 CAP2 TP53BP2

3.09e-0546613511M13522
CoexpressionGSE3982_BCELL_VS_NKCELL_DN

KIF21B REEP1 SYNE1 ARHGAP35 UBQLN3 MMRN2 PALLD

7.49e-051971357M5548
CoexpressionGSE14350_TREG_VS_TEFF_UP

SYNE1 ASTE1 SLC44A2 PRKDC FBXO32 MED17 CSTF2T

7.98e-051991357M3417
CoexpressionGSE11961_MARGINAL_ZONE_BCELL_VS_GERMINAL_CENTER_BCELL_DAY7_DN

TTC39C DENND2B NCAPG SYNE3 CLTC PRKCB FKBP5

8.23e-052001357M9321
CoexpressionGSE22935_24H_VS_48H_MBOVIS_BCG_STIM_MACROPHAGE_UP

PARP11 WNT2 SPTA1 NLRX1 WNK1 CLTC DIAPH2

8.23e-052001357M7776
CoexpressionHALLMARK_MYOGENESIS

ERBB3 REEP1 PPFIA4 DENND2B CHRNG SMTN ACSL1

8.23e-052001357M5909
CoexpressionGSE22886_IGG_IGA_MEMORY_BCELL_VS_BM_PLASMA_CELL_UP

TNIK NRIP1 ARHGEF18 PIKFYVE CDC40 MYLIP PRKCB

8.23e-052001357M4449
CoexpressionGSE5503_LIVER_DC_VS_SPLEEN_DC_ACTIVATED_ALLOGENIC_TCELL_DN

TNIK TTC39C DENND2B DIAPH2 FBXO32 MED17 DNAJC3

8.23e-052001357M6997
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CIB3 LRRC10B IGF1R NEUROD1 ENTPD3 CLTC PRKCB UNC80

1.58e-071951368bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCellcontrol|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ERBB3 DENND2B PTPN13 IGF1R SCNN1A PKP1 SCPEP1 PALLD

1.92e-07200136897f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCellCiliated_cells-B-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

DCDC1 DYNC2H1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

1.78e-0618713672b4262c2e7c7830a976be168cee6eeb738d4feda
ToppCell21-Trachea-Epithelial-Multiciliated_cell|Trachea / Age, Tissue, Lineage and Cell class

DCDC1 DYNC2H1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

1.84e-061881367803bf76a85b3033d2a04b08dd2c03ce9c15529ba
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DCDC1 DYNC2H1 SYNE1 C1orf87 LRRC10B DNAH2 DIAPH2

2.35e-0619513673486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCellControl-Epithelial|Control / Disease state, Lineage and Cell class

ERBB3 RAB25 SYNE1 SLC9C1 PTPN13 SCNN1A USP54

2.35e-0619513671798c3b89b1b5ff4f5777d2b9f52dc81cdad28fa
ToppCellPSB-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DCDC1 DYNC2H1 SYNE1 C1orf87 LRRC10B RIBC1 IQCD

2.51e-0619713676865f4831eb23794fb88a8649d48d497bbae3f44
ToppCellcritical-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DCDC1 DYNC2H1 SYNE1 C1orf87 LRRC10B DNAH2 DIAPH2

2.60e-061981367ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TNIK WNT1 SYNE1 GRM3 LDHD RAPGEF3 TP53BP2

2.78e-0620013677a8160e6477708f22e48c609bf8f43f3715dcb03
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Interneuron|GW09 / Sample Type, Dataset, Time_group, and Cell type.

WNT2 TTC39C LHFPL3 GRM3 EDARADD SAMD3 PDZD2

2.78e-062001367a6500d0d2e8bcac92381ab771dbdee66b0e1d48e
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated|COVID-19_Mild / Disease, condition lineage and cell class

KIF21B SYNE1 TRANK1 PWP2 SAMD3 UTRN PALLD

2.78e-0620013672281debd86e5d92e8fe0397aec9ef670800f7471
ToppCellNS-control|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ERBB3 PTPN13 IGF1R SCNN1A PKP1 SCPEP1 PALLD

2.78e-062001367ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DCDC1 DYNC2H1 C1orf87 LRRC10B DNAH2 IQCD

1.54e-051731366c3762655caa79ac4879876f470d32578a3c93b01
ToppCellfacs-Heart-RA-3m-Lymphocytic-T_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF21B ARHGEF18 FAAH NCAPG EDARADD SAMD3

1.64e-051751366db977f18a71845ecb16ee3e6b3fb03dea4a1a8bc
ToppCellfacs-Heart-RA-3m-Lymphocytic-T_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF21B ARHGEF18 FAAH NCAPG EDARADD SAMD3

1.64e-0517513667b38cbd73be26cf33393c6e6c804d62856a91ec3
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRRK1 GRM3 ADCY8 BMP8A SAMD3 UTRN

1.70e-05176136640993c41c1017b53039a337174fc56632b278609
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DCDC1 REEP1 DYNC2H1 LRRC10B DNAH2 NEUROD1

1.93e-05180136692fb01b91261b3103454924cde56add337b41844
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPFIA4 NEUROD1 NEUROD2 SAMD3 CDH7 UNC80

1.93e-051801366f6a2208960d0df1500c974cc44c3c054cd7475a9
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

TNIK LHFPL3 ADCY8 SLC9C1 PTPN13 PDZD2

2.12e-0518313666847c1252d6bb105524f812658112517fd351eab
ToppCelldroplet-Spleen-nan-18m-Lymphocytic-T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNIK NRIP1 TTC39C PTPN13 IGF1R UTRN

2.18e-0518413668c23945bafe8926f25836bc208115edd5214a2b0
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LHFPL3 ADCY8 SMTN MMEL1 UTRN PLCE1

2.18e-0518413667d41784eac0935e77d6bc701f20c693adf998730
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-Granular_Neuron_CB_Gabra6|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPFIA4 NEUROD1 TRANK1 NEUROD2 SAMD3 UNC80

2.32e-051861366d6c8ce2a32c218dcc63d861cc247152430ed3c8c
ToppCell3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|lymph-node_spleen / Manually curated celltypes from each tissue

UBQLN2 LRG1 SMTN IGF1R KANK3 CAPRIN1

2.39e-0518713663c10b8501226c69d71bcd99dc1c064a3c2154f87
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic-effector_CD4-positive,_alpha-beta_T_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TNIK SYNE1 TTC39C WNK1 FBXO32 FKBP5

2.39e-051871366e61c1755531469dd3850c9740474b5ad4e0499c1
ToppCellCiliated_cells-B-HP_01|World / lung cells shred on cell class, cell subclass, sample id

DCDC1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

2.39e-051871366bc1f33f332ac939c2425f510173430ca2ba0c3ee
ToppCellCOVID-19-Epithelial_cells|COVID-19 / group, cell type (main and fine annotations)

ERBB3 SLC9C1 PTPN13 SCNN1A USP54 PDZD2

2.46e-051881366c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCellControl-Epithelial_cells|Control / group, cell type (main and fine annotations)

LHFPL3 SLC9C1 PTPN13 SCNN1A USP54 PDZD2

2.46e-051881366707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell(7)_Epithelial-F_(Ciliated)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

DCDC1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

2.46e-0518813669a8b9f745eed9f129b6c582f48fbbaaacbebb4b3
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

EAF2 ADCY8 SMTN PXDNL CDH7 PLCE1

2.54e-05189136678cf414b98bcb19deb934409acddaad1cd51b67f
ToppCellCiliated|World / shred by cell class for parenchyma

DCDC1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

2.54e-051891366711181ca3b9102fb155168b646b0a9b09ff215b2
ToppCell343B-Epithelial_cells-Epithelial-F_(Ciliated)|343B / Donor, Lineage, Cell class and subclass (all cells)

DCDC1 DYNC2H1 LRRC10B DNAH2 RIBC1 IQCD

2.61e-051901366169e600e95878000acf5d11f813f9028c7249646
ToppCell343B-Epithelial_cells-Epithelial-F_(Ciliated)-|343B / Donor, Lineage, Cell class and subclass (all cells)

DCDC1 DYNC2H1 LRRC10B DNAH2 RIBC1 IQCD

2.61e-0519013660cc36117c793d83cf4a1f66f47758a07d6712bd3
ToppCelldroplet-Skin-nan-21m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNIK RAB25 ACSL1 ACE2 SCNN1A PKP1

2.69e-051911366c5ef34d138cd797029dfefaf4c52d16ba6a76c38
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC10B SMTN ACE2 PALLD CAP2 PLCE1

2.69e-051911366cb75e6c36dbe2e091e407d691c063ec7c4fd5f90
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC10B SMTN ACE2 PALLD CAP2 PLCE1

2.69e-051911366b2cffea7860dd590b505ee0ebd51aa1978cb5e64
ToppCellnormal_Lung-Epithelial_cells-Ciliated|normal_Lung / Location, Cell class and cell subclass

DCDC1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

2.77e-051921366097a13121820ab4e5cd2365600efccf5ea4ce8c3
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC10B SMTN ACE2 PALLD CAP2 PLCE1

2.77e-051921366e5117cdb8af220f60bd1410262078c0306667b4a
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

REEP1 LRRC10B ACE2 PALLD CAP2 PLCE1

2.85e-0519313661043b28503bfaa0d5a82ec358bc86cbde73ea8f2
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

REEP1 DENND2B SMTN FBXO32 PALLD CAP2

2.85e-051931366a402e736440684ebe123673b6b0c6fcd8fa057b2
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC55 NEUROD1 ENTPD3 CLTC PRKCB UNC80

2.85e-051931366471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC55 NEUROD1 ENTPD3 CLTC PRKCB UNC80

2.85e-051931366fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

REEP1 LRRC10B ACE2 PALLD CAP2 PLCE1

2.85e-0519313660266a4fdf436d83ec1d9392abba8c6ec5166970a
ToppCellfacs-Tongue-nan-3m-Epithelial-keratinocyte|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC44A2 ACSL1 ACE2 ENTPD3 SCNN1A PKP1

2.85e-05193136633437fdb417d78463caee14a9f0e094da1733829
ToppCellfacs-Tongue-nan-18m-Epithelial-keratinocyte|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAB25 TTC39C ACSL1 ACE2 ENTPD3 SCNN1A

2.94e-051941366afc997879e031b49d22a85e107c5849140709b44
ToppCellNS-critical-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DCDC1 DYNC2H1 C1orf87 LRRC10B DNAH2 RIBC1

2.94e-0519413661ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

TNIK SYNE1 PTPN13 SCNN1A USP54 PDZD2

2.94e-05194136697534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UBQLN2 CIB3 LRRC10B NEUROD1 ENTPD3 PRKCB

2.94e-051941366490645bfe9ed3dac03c191c7094df01c780b377e
ToppCellcellseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DYNC2H1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

3.02e-051951366d8bf15aa7cdbc5f29b58e1e6cff76c257f0ea12e
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DYNC2H1 NEUROD1 CLTC PRKCB ASCC3 UNC80

3.02e-0519513663e519cffa6144a62b06124642a14c9ff39b76554
ToppCellnucseq-Epithelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SYNE1 SLC9C1 PTPN13 SCNN1A USP54 PDZD2

3.02e-0519513669406866f99555198a9be311fbd65751b70f35446
ToppCell(1)_Control_(PBS)-(1)_VE-Cad+_vascular_cells|World / Stress and Cell class

LRG1 KANK3 MYLIP CLTC DIAPH2 PDZD2

3.02e-0519513666b5d3ecec0c00ebfc889dc6235390ff53b5c0b6a
ToppCellcellseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DYNC2H1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

3.02e-051951366e7f069f557a59ee7b502ff82ad4c9f47fa619ba8
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DYNC2H1 NEUROD1 CLTC PRKCB ASCC3 UNC80

3.02e-0519513667796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DYNC2H1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

3.11e-051961366a37ba02446eef5d1fab703204583f6550a8ec3e1
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-F_2|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SYNE1 NUP98 WNK1 PTPN13 EDARADD UTRN

3.11e-051961366ea8eceacc5d5e1a22b77c31e7c45985dc7bb15de
ToppCellcritical-Epithelial-Ciliated|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DCDC1 DYNC2H1 C1orf87 LRRC10B DNAH2 IQCD

3.11e-05196136627b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DYNC2H1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

3.11e-051961366a156840330630e518bc85633dded6f2c3ead3b30
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DYNC2H1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

3.11e-051961366009e83c7251cf300be78b263634d233a8d972a68
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DYNC2H1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

3.11e-05196136689ea4d2086e1c769c5a87f1471a6cd4acabcfe33
ToppCellNS-control-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DCDC1 DYNC2H1 SYNE1 C1orf87 LRRC10B DNAH2

3.11e-051961366d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DCDC1 DYNC2H1 SYNE1 C1orf87 DNAH2 ANKRD26

3.20e-05197136674a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellNS-critical-d_07-13|critical / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ERBB3 RAB25 DENND2B LRG1 SCNN1A PALLD

3.29e-051981366a6e11c87b31beffb6af190c64b4ef3ee1d9dab8d
ToppCelldistal-Epithelial-Ciliated-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DCDC1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

3.39e-0519913662de1fe124737a6cca4b3805ab3056f9d9d7c16c7
ToppCelldistal-Epithelial-Ciliated|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DCDC1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

3.39e-05199136618ca031cfe702afb9bf94e03c0f3680c38e7599e
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SYNE1 LHFPL3 AKR1E2 BMP8A UNC80 PDZD2

3.39e-05199136619a97e27a4758e794ce7246d295e112b47931a48
ToppCelldistal-3-Epithelial-Ciliated|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DCDC1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

3.39e-0519913667e5f29f4ec1fea92f2c0064eea151d2d474ef904
ToppCelldistal-Epithelial-Ciliated-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DCDC1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

3.39e-0519913666ce0df4a6f4d9353919e26ffab97c9ec89911da6
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

RAB25 FAAH PTPN13 SCNN1A USP54 UTRN

3.48e-052001366c89f3cb36bb14c476d6a392bfd3ded1c8feecfeb
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DCDC1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

3.48e-05200136652aef65f01b06cd98056f17977efe525aee6eb6f
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DCDC1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

3.48e-05200136655c148238d5c80c1faa3428a917ae8075be2c145
ToppCellBronchus_Control_(B.)-Epithelial-TX-Ciliated|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

DCDC1 DYNC2H1 SYNE1 C1orf87 LRRC10B IQCD

3.48e-0520013666a2ccc71a0cbe04a542c379b28b5006de53981c3
ToppCellLung_Parenchyma-Control-Epithelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ERBB3 RAB25 SYNE1 PTPN13 SCNN1A USP54

3.48e-052001366c2bde99b3bc7a8740441c1a0c1394892b940b857
ToppCellLPS_IL1RA|World / Treatment groups by lineage, cell group, cell type

LAP3 NFKBIE DIAPH2 ASCC3 TP53BP2 LRRC15

3.48e-052001366a02fa5b3c4723a6eaa3c685588666c710478dd25
ToppCellBiopsy_Other_PF-Epithelial-Ciliated|Biopsy_Other_PF / Sample group, Lineage and Cell type

DCDC1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

3.48e-052001366721371698bce8890853fb6b6b01a2c20293b39e9
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DCDC1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

3.48e-05200136685c98da55f7cd4ffdf9d309b56c8cc5d43f3c04c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TNIK SYNE1 GRM3 LDHD RAPGEF3 TP53BP2

3.48e-052001366d0812817ef99608994193787a62d39adeb2070ca
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ERBB3 RAB25 SYNE1 PTPN13 SCNN1A USP54

3.48e-0520013663ff9abd5e07780a59d5571da906fa15f00a1d5c2
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_ciliated|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

DCDC1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

3.48e-0520013665abd6d81e1cc354484ae693fcd708d78926e75b5
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_ciliated-Ciliated|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

DCDC1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

3.48e-0520013669c9d2b0276c7b0709c2eeeb0673a2f58106fb14e
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DCDC1 C1orf87 LRRC10B DNAH2 RIBC1 IQCD

3.48e-05200136612bc7d95c4166d12487081a76d210b7abe5991b0
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SYNE1 SMTN DIAPH2 FBXO32 PALLD CAP2

3.48e-052001366dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCellParenchyma_Control_(B.)-Epithelial-TX|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

ERBB3 RAB25 SYNE1 PTPN13 SCNN1A USP54

3.48e-0520013669970e9bde6aa2ff3aef60dcb065ff15b7463e147
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TNIK SYNE1 GRM3 LDHD RAPGEF3 TP53BP2

3.48e-052001366cd54ddf1919c98e84b7e4aba85b374fc8b407206
ToppCellLPS_IL1RA-Mesenchymal_myocytic|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SYNE1 SMTN FBXO32 PALLD CAP2 PLCE1

3.48e-05200136677631c471cc5d453a749784f838cfa6408caf09b
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PPFIA4 ENTPD3 PALLD CAP2 PLCE1

1.04e-0415213650cb5f4dfae04e3f4eba502bbf229007d5fa3884d
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PPFIA4 ENTPD3 PALLD CAP2 PLCE1

1.04e-041521365ba89ffb5a8bb33c188f854f54b39123b6d73496a
ToppCell10x5'-Lung-Myeloid_Monocytic-Cycling_mono|Lung / Manually curated celltypes from each tissue

HAUS5 FAAH SMTN NCAPG TP53BP2

1.17e-04156136563b8cf14361b282872bc1c5b65d9fbc83e81a089
ToppCellBasal_cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

ARHGEF18 SLITRK5 PKP1 FBXO32 PLCE1

1.25e-041581365dd069a822e9698e6dddc155d9a5b52383f7879d5
ToppCellfacs-Lung-EPCAM-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF18 FAAH EDARADD CSTF2 SAMD3

1.36e-0416113658e787cc7f5e818cad1a6ed143a5fe310993e030b
ToppCellfacs-Lung-EPCAM-3m-Lymphocytic-CD8+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF18 FAAH EDARADD CSTF2 SAMD3

1.36e-041611365ca9233370490e27b9a1892669d6b82db2136180e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RTL5 PPFIA4 SAMD3 CDH7 PALLD

1.48e-041641365b6df1e67a5ce5f2d86f4e1420f4ee931f760bf4d
ToppCelldroplet-Fat-Gat-18m-Hematologic|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTA1 ACSL1 NCAPG TRANK1 ENTPD3

1.48e-0416413657dbe34a98a3b475c1ba678db8a5494c0c6a91e2d
ToppCelldroplet-Fat-Gat-18m-Hematologic-erythroblast|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTA1 ACSL1 NCAPG TRANK1 ENTPD3

1.48e-041641365febcb8f8b305aa94e21131fa83d2890f7a6838fc
ToppCellPND14-Epithelial-Epithelial_Airway-Neurosecretory|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RAB25 ACE2 PTPN13 ENTPD3 SCNN1A

1.53e-0416513656fdce8b23736409a23884ef3918638ffc067a86f
ToppCellPND14-Epithelial-Epithelial_Airway-Neurosecretory-Secretory|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RAB25 ACE2 PTPN13 ENTPD3 SCNN1A

1.53e-041651365dd4d36ff8efb89fee1fb4c48d1b8f46902119909
ToppCellPND14-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RAB25 ACE2 PTPN13 ENTPD3 SCNN1A

1.53e-041651365baff639a7046fb5cacb70f341b6d24cef3519f8e
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-Exhausted_Tfh|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

DNAH2 SLC44A2 LDHD SYNE3 FKBP5

1.57e-041661365c73fce59256ad501864f44f76cfae2fc33b3777e
ToppCellE16.5-Endothelial-Endothelial_lymphatic|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

REEP1 LRG1 SYNE3 UTRN LRRC15

1.61e-041671365b93103a868fba63a8910bffb690a6242b9252833
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2-Exc_L5-6_FEZF2_MYBPHL|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LHFPL3 SLC9C1 SYNE3 MYLIP SAMD3

1.61e-041671365c7d1e84af1f4d7430858287520ac2cfa36203642
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

REEP1 LRG1 SYNE3 UTRN LRRC15

1.61e-041671365fcd583b1efd0ac883379982ea8e6c54f2c0be268
Diseaseamyotrophic lateral sclerosis type 15 (implicated_via_orthology)

UBQLN2 UBQLN1

5.41e-0531262DOID:0060206 (implicated_via_orthology)
Diseasenervous system disorder

CASP9 TTC19 NEUROD1 NOD1

7.89e-05531264C0027765
Diseaseosteoporosis (is_implicated_in)

NRIP1 WNT1 IGF1R

3.13e-04311263DOID:11476 (is_implicated_in)
Diseasemuscular atrophy (implicated_via_orthology)

CHUK FBXO32

3.75e-0471262DOID:767 (implicated_via_orthology)
Diseaseplatelet component distribution width

NRIP1 OR11L1 SYNE1 SPTA1 SLC44A2 BTBD2 WNK1 IGF1R TRANK1 CLPB RAPGEF3

4.05e-0475512611EFO_0007984
Diseasepseudohypoaldosteronism (is_implicated_in)

WNK1 SCNN1A

4.98e-0481262DOID:4479 (is_implicated_in)
Diseasecup-to-disc ratio measurement

DCDC1 ARHGAP35 ADCY8 IGF1R SYNE3 RAPGEF3 PLCE1 PDZD2

5.36e-044301268EFO_0006939
DiseaseParoxysmal atrial fibrillation

REEP1 PPFIA4 WNT8A IGF1R FBXO32

5.66e-041561265C0235480
Diseaseprostate cancer (is_marker_for)

ERBB3 EAF2 WNT2 DAXX IGF1R

5.66e-041561265DOID:10283 (is_marker_for)
Diseasefamilial atrial fibrillation

REEP1 PPFIA4 WNT8A IGF1R FBXO32

5.66e-041561265C3468561
DiseasePersistent atrial fibrillation

REEP1 PPFIA4 WNT8A IGF1R FBXO32

5.66e-041561265C2585653
DiseaseAtrial Fibrillation

REEP1 PPFIA4 WNT8A IGF1R FBXO32

6.34e-041601265C0004238
DiseaseMood Disorders

TBC1D25 GRM3 ADCY8 FKBP5 PMCH

7.90e-041681265C0525045
DiseasePseudohypoaldosteronism, Type I

WNK1 SCNN1A

7.96e-04101262C0268436
DiseasePseudohypoaldosteronism

WNK1 SCNN1A

7.96e-04101262C0033805
DiseaseHyperpotassemia and Hypertension, Familial

WNK1 SCNN1A

7.96e-04101262C2713447
DiseasePseudohypoaldosteronism, Type I, Autosomal Recessive

WNK1 SCNN1A

7.96e-04101262C1449843
DiseasePseudohypoaldosteronism, Type II

WNK1 SCNN1A

7.96e-04101262C1449844
DiseasePseudohypoaldosteronism, Type I, Autosomal Dominant

WNK1 SCNN1A

7.96e-04101262C1449842
DiseaseBipolar Disorder

ERBB3 SYNE1 GRM3 ADCY8 TRANK1 CDH7 FKBP5 PMCH

1.05e-034771268C0005586
Diseasefrontotemporal dementia (implicated_via_orthology)

UBQLN2 UBQLN1

1.16e-03121262DOID:9255 (implicated_via_orthology)
Diseaseamyotrophic lateral sclerosis (biomarker_via_orthology)

CASP9 IGF1R

1.37e-03131262DOID:332 (biomarker_via_orthology)
DiseaseR-6-hydroxywarfarin measurement

LHFPL3 DNAH2 ENTPD3 PALLD

1.47e-031141264EFO_0803327
Diseasepancreatic ductal carcinoma (is_marker_for)

ACE2 IGF1R PALLD

2.28e-03611263DOID:3587 (is_marker_for)
Diseasehypertrophic cardiomyopathy (is_marker_for)

ACE2 IGF1R

2.36e-03171262DOID:11984 (is_marker_for)
DiseaseAdrenocortical carcinoma

DAXX IGF1R

2.65e-03181262C0206686
DiseaseColorectal Carcinoma

SYNE1 WNK1 ADCY8 SMTN NCAPG RPAP1 MMRN2 PRKCB CDH7

3.24e-037021269C0009402
Diseasecarotid artery intima media thickness

DYNC2H1 LRRC55 SYNE3 SAMD3 FBXO32 PALLD PDZD2

3.27e-034501267EFO_0007117
Diseaseheart failure, diabetes mellitus, stroke, atrial fibrillation, mortality, coronary artery disease, cancer

DNAH2 ANKRD26

3.27e-03201262EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004352, MONDO_0004992
Diseaseneurodegenerative disease (implicated_via_orthology)

UBQLN2 UBQLN1 MYLIP SCNN1A

3.52e-031451264DOID:1289 (implicated_via_orthology)
Diseaseobesity (biomarker_via_orthology)

ACSL1 IGF1R PRKCB PMCH

3.70e-031471264DOID:9970 (biomarker_via_orthology)
Diseaseobesity

LHFPL3 NUP98 ADCY8 CLPB SCNN1A

3.82e-032411265EFO_0001073
DiseaseNasopharyngeal carcinoma

ERBB3 SYNE1

3.95e-03221262C2931822

Protein segments in the cluster

PeptideGeneStartEntry
SAQELVRMLNELFAR

ADCY8

431

P40145
MRANDALQVLGLLFS

ERBB3

1

P21860
NGLTFRKEDMLQRQL

ARHGEF18

671

Q6ZSZ5
FQGLRQLDMLDLSNN

LRG1

256

P02750
NLLFMSVRDQDREGA

CTAG2

131

O75638
NRMFDRIFGQANTTL

ACSL1

371

P33121
ARLLQMQTQGRSAEA

IQCD

166

Q96DY2
QGRNQEERLLADLMQ

CHRNG

21

P07510
NEDRGIQRLEAMLFA

GRM3

61

Q14832
QRLLSDNGINRLSLM

BRPF3

896

Q9ULD4
SREQNARMLQDGILT

ANKRD26

866

Q9UPS8
GNRQNLELLLEMSFN

ANKRD52

561

Q8NB46
MDNLLEALQSGAAFR

DIAPH2

1056

O60879
DQETALSAMRNLNGR

CSTF2

66

P33240
EALMVNLGSDRFIRQ

DENND2B

966

P78524
RMNKGERLNQDQLDA

CAPRIN1

81

Q14444
SDEMQRLRSQALNAF

DNAJC3

151

Q13217
LMAQDAFRDVGIRLQ

DAXX

311

Q9UER7
RMFDVLQRFGSQRNE

TP53BP2

61

Q13625
EGNNRFGLLMVENLE

ASTE1

656

Q2TB18
IDQALRRFRSGENML

C1orf87

521

Q8N0U7
GMRLLRLQNETAANE

ENTPD3

141

O75355
RMFAENNGLLFLETS

RAB25

141

P57735
LGFNSQVLQADMLRI

PABIR3

36

Q6P4D5
LFASGQNLARQLMET

LAP3

191

P28838
RRGEAQLLMNEFESA

FKBP5

356

Q13451
LNLNMAARRVFLADG

DCDC1

206

M0R2J8
DTIVALNMRAALRNG

NUP98

686

P52948
QAFQGLMQLRDLDLS

LRRC55

156

Q6ZSA7
GRIDNVDAFMNIRLA

LSM10

41

Q969L4
DRLLQQGSAVFQFRM

DOLK

61

Q9UPQ8
GSGESFMQLQQRLLR

GTPBP6

251

O43824
QLDALMFLRLQGNQL

LRRK1

471

Q38SD2
ARLGQLQRNLSELHM

MMRN2

371

Q9H8L6
QGQRAAMLSLLRYNA

CHUK

446

O15111
MEREFNNLLALGTDR

PPFIA4

1091

O75335
QFLLQAGAQVDARML

NFKBIE

421

O00221
AMETDDAGNRLRFQL

MED31

6

Q9Y3C7
EIQTFRERNRGSNMF

CAP2

116

P40123
QLGFLVSDRDRNLMV

CPSF1

1266

Q10570
RGNNIASELENFMGL

IGF1R

366

P08069
LAALGQVFRNQDTRM

PNMA6E

391

A0A0J9YXQ4
GNIMASDRLERTNQL

PDZD2

2076

O15018
NTCLNRGFSRLLDNM

PEX3

281

P56589
RIIRGNQLQEFAAML

COPS4

271

Q9BT78
FRENAMLQKENGALR

KIF21B

421

O75037
RIQALFENAMRSDSG

NRDE2

1071

Q9H7Z3
SGLQERDMQLGFLRA

NOD1

486

Q9Y239
LNLRNRISQQMDGLA

MYLIP

56

Q8WY64
EREFNNLLVMGTDRR

PPFIA1

1111

Q13136
NQAASERLAAMARLQ

NRIP1

291

P48552
VALQSLQMGDNRLRA

LRRC10B

136

A6NIK2
NGNRDRMKLTDFNFL

PRKCB

331

P05771
MSQNLARLAQRIDFS

MED17

36

Q9NVC6
ALLLRAQAGAMRRQQ

HAUS5

126

O94927
QRDHLVQMLSRNLEG

NLRX1

346

Q86UT6
LMISRLDFCGRNQIN

OR11L1

161

Q8NGX0
MANRNNVTEFILLGL

OR4C13

1

Q8NGP0
ALMNSQFNRRVLIDL

MMEL1

221

Q495T6
ELGLSRAALQMQFNA

PALLD

591

Q8WX93
NEVANLFGKTMDRNR

PARP11

151

Q9NR21
RNMGEIENFRNSFGL

PCDHB14

781

Q9Y5E9
RLNVFDDGTLMIRNT

PXDNL

281

A1KZ92
MAQVFDLKGSLRNRN

PIKFYVE

1946

Q9Y2I7
NFLDDGNQMLLRVQR

DYNC2H1

41

Q8NCM8
HNRFRDNSGLLMNTL

EAF2

231

Q96CJ1
GQDMLASFLRTNRQA

CASP9

81

P55211
NAVRYGTMRDNVLNL

LDHD

176

Q86WU2
EQRLGRADLVMSFVN

BMP8A

96

Q7Z5Y6
MSRSRINDAFRLNDN

ACE2

706

Q9BYF1
EMRAFNIDRELGSAN

DNAJC13

791

O75165
EFLLRNSQRTVGQLM

EDARADD

166

Q8WWZ3
NRQNRAGYSALMLAA

KANK3

651

Q6NY19
ANGVLEARQLAMRIF

SLC44A2

211

Q8IWA5
AARANNMQEVSRLLS

CLPB

141

Q9H078
DQETALSAMRNLNGR

CSTF2T

66

Q9H0L4
GLENMDRAAQRFRLQ

FAAH

51

O00519
FDMAALRNLNVIRDT

CDH7

666

Q9ULB5
CLQLNIMQRLSDGRD

FBXO32

231

Q969P5
NLRADNAFMLLTQAR

BTBD2

216

Q9BX70
MREEENSLRANLGIF

DNAH2

1196

Q9P225
NGLSLMLRAEQNDFI

SCNN1A

326

P37088
RNLDDDMVFNTFRLG

PMCH

31

P20382
LNLQAESVRGFNMGR

PTPN13

891

Q12923
LERLRAALMESQGQQ

NUMA1

981

Q14980
LRQQGFDRNMLGTLA

PKP1

721

Q13835
GNLNSLRMANVALRE

RTL5

6

Q5HYW3
LAQMRQRDANLTALA

TAF4

996

O00268
NVRDQALILMNARGS

UTRN

1706

P46939
SLDGLQQLRDNMGSR

TBC1D25

506

Q3MII6
IFNTEAMELANRRLL

SLC9C1

506

Q4G0N8
ESRDLQDRLSQMNGR

SYNE1

8516

Q8NF91
EFRMVLQRLAQEGLQ

SYNE3

346

Q6ZMZ3
NALQDLDGNVFRMLA

LRRC15

351

Q8TF66
LDGNVFRMLANLQNI

LRRC15

356

Q8TF66
LFINSRRMEENSSGN

PLCE1

1981

Q9P212
VRHLQRDALSQLMNG

SCPEP1

301

Q9HB40
SGAALLALNDRMVQQ

SAMD3

31

Q8N6K7
MDNQILIFGAQNRFR

CDC40

481

O60508
QGALSERLRSFSMQD

REEP1

141

Q9H902
LLGIDVSRGMNRNFD

ARHGAP35

161

Q9NRY4
DNILSLNRNLRLAMF

AKR1E2

291

Q96JD6
MLRQDRNLVENLFSN

ASCC3

786

Q8N3C0
DGRLSLEDFQNMILR

CIB3

161

Q96Q77
DLALRMAVRNNLAGA

CLTC

346

Q00610
RVMLLQQGLNDRSDA

NCAPG

246

Q9BPX3
LMANLAFIRGQLENA

TTC19

141

Q6DKK2
TANLERFMRRFNELQ

RAPGEF3

701

O95398
RRFQQMDVLEGLNVL

TNIK

1086

Q9UKE5
DARALMNLHNNRAGR

WNT2

181

P09544
VMQLQGRNLADLRRS

TTBK1

106

Q5TCY1
FTNQERREGMLLNLL

UNC80

2701

Q8N2C7
DLDRDTRLRMQQGQF

RIBC1

146

Q8N443
SMIQDRAFGDLTNLR

SLITRK5

446

O94991
QQDFTRAILMALRLN

PWP2

756

Q15269
LEQLSAMGFLNREAN

UBQLN1

551

Q9UMX0
AMGFLNREANLQALI

UBQLN1

556

Q9UMX0
AAAAEMQRFSDLLQR

CREBZF

151

Q9NS37
LMGTNIRDFLEEANR

RRP8

366

O43159
SLNQNMESLRARAAR

SPTA1

876

P02549
TQERMQARFSLQGEL

RPAP1

351

Q9BWH6
VLNGMLDQSFRERAN

PRKDC

1596

P78527
RDVMLENFRNLLSVG

ZNF221

56

Q9UK13
GRDLRFLMNLHNNEA

WNT1

191

P04628
AMGFLNREANLQALI

UBQLN2

591

Q9UHD9
ARALMNLHNNRAGRL

WNT8A

156

Q9H1J5
LSLQQAFSELRRAQM

WNK1

1301

Q9H4A3
GINMLLNNGFRESDQ

TTC39C

36

Q8N584
MFFEGLRLVQRSQDQ

TRANK1

71

O15050
GVLDMLNNFRVDSAL

TRIM64

276

A6NGJ6
GVLDMLNNFRVDSAL

TRIM64B

276

A6NI03
EQLRSMGFLNREANL

UBQLN3

621

Q9H347
MGFLNREANLQALIA

UBQLN3

626

Q9H347
RAALARLAGQLESMN

SMTN

76

P53814
SRFMDLDELQNQGRS

USP54

776

Q70EL1
LAFVLGNRQDSLMAE

LHFPL3

206

Q86UP9
AGRLSMQELRSQDVN

NDC80

11

O14777
RNRMHGLNAALDNLR

NEUROD1

111

Q13562
RNRMHDLNAALDNLR

NEUROD2

131

Q15784