Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11 POLM POLA1

8.97e-1338407GO:0034061
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11

1.14e-1111405GO:0004523
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11

4.92e-1114405GO:0003964
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-8 ERVK-6 ERVK-19 ERVK-7 ERVK-25 ERVK-10

9.69e-1137406GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-8 ERVK-6 ERVK-19 ERVK-7 ERVK-25 ERVK-10

1.15e-1038406GO:0070001
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11

4.95e-1021405GO:0035613
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11

1.04e-0837405GO:0016891
GeneOntologyMolecularFunctionnucleotidyltransferase activity

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11 POLM POLA1

1.95e-08152407GO:0016779
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11

3.21e-0846405GO:0016893
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11

5.03e-0779405GO:0004521
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11 POLM POLA1

7.96e-07262407GO:0140097
GeneOntologyMolecularFunctionzinc ion binding

ERVK-8 ERVK-6 TRAF7 ERVK-19 PAPPA ERVK-7 ERVK-10 HERC2 HDAC6 ERVK-11 POLA1

9.24e-078914011GO:0008270
GeneOntologyMolecularFunctionendopeptidase activity

ERVK-8 ADAMTS10 ERVK-6 ERVK-19 PAPPA ERVK-7 ERVK-25 ERVK-10

1.82e-06430408GO:0004175
GeneOntologyMolecularFunctionRNA nuclease activity

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11

7.40e-06136405GO:0004540
GeneOntologyMolecularFunctionendonuclease activity

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11

7.40e-06136405GO:0004519
GeneOntologyMolecularFunctiontransition metal ion binding

ERVK-8 ERVK-6 TRAF7 ERVK-19 PAPPA ERVK-7 ERVK-10 HERC2 HDAC6 ERVK-11 POLA1

1.48e-0511894011GO:0046914
GeneOntologyMolecularFunctionpeptidase activity

ERVK-8 ADAMTS10 ERVK-6 ERVK-19 PAPPA ERVK-7 ERVK-25 ERVK-10

3.86e-05654408GO:0008233
GeneOntologyMolecularFunctionnuclease activity

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11

9.38e-05231405GO:0004518
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11 POLM POLA1

2.62e-04645407GO:0140640
GeneOntologyMolecularFunctionhydrolase activity, acting on ester bonds

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11 ACP3 DUSP8

9.97e-04807407GO:0016788
GeneOntologyMolecularFunctionDNA-directed DNA polymerase activity

POLM POLA1

1.14e-0325402GO:0003887
GeneOntologyMolecularFunctioncatalytic activity, acting on RNA

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11

1.40e-03417405GO:0140098
GeneOntologyMolecularFunctionstructural molecule activity

ERVK-8 ERVK-6 ERVK-19 ERVK-7 ERVK-25 ERVK-10 FBN3

1.77e-03891407GO:0005198
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11 POLM POLA1

2.37e-03938407GO:0016772
GeneOntologyMolecularFunctionbeta-tubulin binding

HDAC6 BCAS3

4.34e-0349402GO:0048487
GeneOntologyBiologicalProcessDNA integration

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11

2.36e-1113395GO:0015074
GeneOntologyBiologicalProcessDNA synthesis involved in DNA repair

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11 POLA1

3.54e-1048396GO:0000731
GeneOntologyBiologicalProcessDNA biosynthetic process

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11 POLM POLA1

1.54e-07218397GO:0071897
GeneOntologyBiologicalProcessRNA-templated DNA biosynthetic process

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11

4.83e-0783395GO:0006278
GeneOntologyBiologicalProcessDNA-templated DNA replication

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11 POLA1

9.78e-07178396GO:0006261
GeneOntologyBiologicalProcessDNA repair

ERVK-8 ERVK-6 ERVK-7 ERVK-10 HERC2 ERVK-11 POLM POLA1

2.36e-05648398GO:0006281
GeneOntologyBiologicalProcessDNA replication

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11 POLA1

2.45e-05312396GO:0006260
GeneOntologyBiologicalProcessDNA damage response

ERVK-8 ERVK-6 ERVK-7 ERVK-10 HERC2 ERVK-11 POLM POLA1 GTSE1

5.87e-05959399GO:0006974
GeneOntologyBiologicalProcessDNA recombination

ERVK-8 ERVK-6 ERVK-7 ERVK-10 ERVK-11 POLM

6.14e-05368396GO:0006310
GeneOntologyBiologicalProcessnegative regulation of receptor internalization

RIN3 LRRTM1

5.23e-0418392GO:0002091
GeneOntologyBiologicalProcesscell-cell fusion

ERVK-8 ERVK-6 ERVK-19

5.55e-0485393GO:0140253
GeneOntologyBiologicalProcesssyncytium formation by plasma membrane fusion

ERVK-8 ERVK-6 ERVK-19

5.55e-0485393GO:0000768
GeneOntologyBiologicalProcesssyncytium formation

ERVK-8 ERVK-6 ERVK-19

6.34e-0489393GO:0006949
GeneOntologyCellularComponentmicrofibril

ADAMTS10 FBN3

2.61e-0413392GO:0001527
DomainNUT

NUTM2B NUTM2A

3.02e-055332IPR024310
DomainNUT_N

NUTM2B NUTM2A

3.02e-055332IPR024309
DomainNUT

NUTM2B NUTM2A

3.02e-055332PF12881
DomainPLAC

ADAMTS10 ADAMTSL1

2.72e-0414332PF08686
DomainEGF_CA

TPO NELL1 FBN3

4.65e-0486333PF07645
DomainVWC_out

NELL1 MUC5B

5.08e-0419332SM00215
DomainPLAC

ADAMTS10 ADAMTSL1

5.08e-0419332IPR010909
DomainPLAC

ADAMTS10 ADAMTSL1

5.08e-0419332PS50900
DomainEGF_Ca-bd_CS

TPO NELL1 FBN3

6.62e-0497333IPR018097
DomainEGF_CA

TPO NELL1 FBN3

7.02e-0499333PS01187
DomainASX_HYDROXYL

TPO NELL1 FBN3

7.23e-04100333PS00010
DomainPeptidase_M12B_ADAM-TS

ADAMTS10 ADAMTSL1

8.15e-0424332IPR013273
DomainEGF-type_Asp/Asn_hydroxyl_site

TPO NELL1 FBN3

8.57e-04106333IPR000152
DomainVWC

NELL1 MUC5B

1.11e-0328332PF00093
DomainEGF_CA

TPO NELL1 FBN3

1.29e-03122333SM00179
DomainWD40_repeat

MIOS TRAF7 HERC2 BCAS3

1.29e-03272334IPR001680
DomainEGF-like_Ca-bd_dom

TPO NELL1 FBN3

1.35e-03124333IPR001881
DomainWD_REPEATS_1

MIOS TRAF7 HERC2 BCAS3

1.40e-03278334PS00678
DomainWD_REPEATS_2

MIOS TRAF7 HERC2 BCAS3

1.42e-03279334PS50082
DomainWD_REPEATS_REGION

MIOS TRAF7 HERC2 BCAS3

1.42e-03279334PS50294
DomainVWFC_1

NELL1 MUC5B

1.84e-0336332PS01208
DomainVWC

NELL1 MUC5B

2.05e-0338332SM00214
DomainVWFC_2

NELL1 MUC5B

2.05e-0338332PS50184
DomainVWF_dom

NELL1 MUC5B

2.49e-0342332IPR001007
DomainSushi

TPO PAPPA

3.80e-0352332PF00084
DomainCCP

TPO PAPPA

4.09e-0354332SM00032
DomainSUSHI

TPO PAPPA

4.39e-0356332PS50923
DomainVWA

ANTXRL CACNA2D4

4.39e-0356332PF00092
DomainSushi_SCR_CCP_dom

TPO PAPPA

4.55e-0357332IPR000436
DomainRetrov_capsid_C

ADAMTS10 ERVK-6

4.86e-0359332IPR008916
DomainTSP_1

ADAMTS10 ADAMTSL1

5.53e-0363332PF00090
DomainTSP1

ADAMTS10 ADAMTSL1

5.87e-0365332SM00209
DomainTSP1_rpt

ADAMTS10 ADAMTSL1

5.87e-0365332IPR000884
DomainTSP1

ADAMTS10 ADAMTSL1

5.87e-0365332PS50092
DomainRNaseH-like_dom

ERVK-6 POLA1

6.60e-0369332IPR012337
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTS10 MUC5B ADAMTSL1 GPC2

9.21e-05143244M27275
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS10 MUC5B ADAMTSL1

2.02e-0468243M27303
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-8 ERVK-6 ERVK-19 ERVK-7 ERVK-25 ERVK-10 ERVK-11

2.96e-119444721542922
Pubmed

Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.

ERVK-6 ERVK-19 ERVK-10

7.55e-0944437983737
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-6 ERVK-7 ERVK-10

7.55e-09444310469592
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-19 ERVK-7

1.89e-08544312629516
Pubmed

Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.

ADAMTS10 TPO ADAMTSL1 HERC2 FBN3

7.35e-088444515203218
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-8 ERVK-6 ERVK-19

4.12e-071244314557543
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-25 ERVK-10 ERVK-11

1.52e-061844318664271
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

1.56e-0624429060628
Pubmed

Homozygosity mapping of a Weill-Marchesani syndrome locus to chromosome 19p13.3-p13.2.

ADAMTS10 FBN3

1.56e-06244211941487
Pubmed

Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

ERVK-6 ERVK-19

1.56e-0624429460924
Pubmed

The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.

NUTM2B NUTM2A

4.69e-06344222456610
Pubmed

Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.

ERVK-6 ERVK-19

4.69e-06344210516026
Pubmed

The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.

NUTM2E NUTM2B

4.69e-06344226542179
Pubmed

Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.

ERVK-6 ERVK-11

4.69e-0634429971820
Pubmed

Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.

ERVK-6 ERVK-7

1.56e-05544211401426
Pubmed

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

ERVK-6 ERVK-19

2.34e-05644215063128
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

LRP3 TRAF7 RIN3 GPC2 HERC2 BCAS3 PRRT4 GTSE1

6.49e-05110544835748872
Pubmed

Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.

ERVK-6 ERVK-19

6.99e-051044212970426
Pubmed

E3-independent monoubiquitination of ubiquitin-binding proteins.

HDAC6 POLM

1.63e-041544217588522
Pubmed

Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort.

NELL1 HERC2

3.56e-042244219174780
Pubmed

Genetic risk profiling and prediction of disease course in Crohn's disease patients.

NELL1 HERC2

5.79e-042844219422935
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

ADAMTS10 ERVK-25 ERVK-10 HERC2 POLA1 FBN3 GTSE1

7.72e-04121544715146197
Cytoband11p15.5

MUC5B TMEM80 DUSP8

1.90e-0411843311p15.5
Cytoband10q11.22

ANTXRL FRMPD2B

6.87e-044143210q11.22
Cytoband10q22.3

NUTM2E NUTM2B

7.55e-044343210q22.3
CytobandEnsembl 112 genes in cytogenetic band chr11p15

NELL1 MUC5B TMEM80 DUSP8

1.90e-03564434chr11p15
GeneFamilyDNA polymerases

POLM POLA1

4.56e-0423252535
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

TPO PAPPA

2.80e-03572521179
DrugU-78036

ERVK-6 POLM POLA1

5.96e-0622373CID000072244
DiseaseEndometrial Stromal Sarcoma

NUTM2B NUTM2A

1.53e-055372C0206630
DiseaseClear cell sarcoma of kidney

NUTM2E NUTM2B

2.29e-056372C0334488
Diseaserefractive error

ADAMTSL1 FRMPD2B BCAS3 FBN3

7.25e-04326374MONDO_0004892
Diseasechronic obstructive pulmonary disease

PPARGC1B RIN3 ADAMTSL1 BCAS3 LINC02693

1.60e-03688375EFO_0000341
DiseaseUveal Melanoma

ADAMTSL1 HERC2

2.03e-0353372EFO_1000616
Diseaseirritable bowel syndrome symptom measurement

NELL1 ANTXRL

2.42e-0358372EFO_0021536
Diseasecholangiocarcinoma (is_marker_for)

MUC5B HDAC6

2.94e-0364372DOID:4947 (is_marker_for)
Diseasesquamous cell carcinoma

PPARGC1B HERC2

3.21e-0367372EFO_0000707
Diseasenicotine dependence

NELL1 ADAMTSL1

4.33e-0378372EFO_0003768
Diseasesmall cell lung carcinoma

NELL1 ADAMTSL1

4.55e-0380372EFO_0000702

Protein segments in the cluster

PeptideGeneStartEntry
MQPASPGQPLCPLLR

TTC21B

461

Q7Z4L5
PPICLGRAPGCLMPA

ERVK-19

161

O71037
PPICLGRAPGCLMPA

ERVK-8

161

Q902F8
LSLPQAPCSPRMCLR

ANTXRL

501

A6NF34
PAALLPMSLSQPCLP

DUSP8

141

Q13202
TFACVCPPGMRPLPG

FBN3

2231

Q75N90
SCYPCPGPNMNPIAL

BCAS3

221

Q9H6U6
PPATMRCNLRRCPPA

ADAMTS10

991

Q9H324
RMAAAPPGCTPPALL

POLM

86

Q9NP87
TPTPCPPQPLCDLML

MUC5B

5281

Q9HC84
MLPAAPSGCPQLCRC

LRRTM1

31

Q86UE6
PLCRGVPSLMPCQGF

GPC2

261

Q8N158
DRLATPCMPPLCSSP

HERC2

401

O95714
CPAGCRLSFNLPPSM

LINC02693

191

A8MQB3
LCPPLPFSSSIRPCM

ADAMTSL1

831

Q8N6G6
SGCLPYMLPPKCPNT

TPO

131

P07202
GVCRNPPPPCSPMLE

LRP3

746

O75074
LCELMCLAPPPVPNA

PAPPA

1341

Q13219
PPICLGRAPGCLMPA

ERVK-7

921

P63135
PLQFSRTGPLCPACM

POLA1

1361

P09884
LPTPASRRCSGLPPM

GTSE1

511

Q9NYZ3
RMSCPPLNCSPDSLP

NELL1

306

Q92832
PLMLPGCSPSCPLER

ACP3

341

P15309
PPICLGTAPGCLMPA

ERVK-25

161

P61570
PPICLGRAPGCLMPA

ERVK-6

161

Q69384
MVCGCSALLPLPNPR

CACNA2D4

1

Q7Z3S7
TLLLCRPPPGALPEM

FRMPD2B

171

Q6IN97
GLCPPPAILPTSMCQ

MS4A15

21

Q8N5U1
PPICLGRAPGCLMPA

HERVK_113

161

Q902F9
PCPMLESPGAPCRSA

HDAC6

406

Q9UBN7
LCSPLPCMIPLQPLG

FEZF2

66

Q8TBJ5
GMRLCLPANPKNCLP

RIN3

31

Q8TB24
MSGPLSPVCSCPQLP

INE1

1

O15225
RMSPTPNSCPLPLPL

NUTM2A

51

Q8IVF1
PNSCPLPLPLCRMSG

NUTM2A

56

Q8IVF1
PNSCPLPLPLCRMSG

NUTM2B

56

A6NNL0
PNSCPLPLPLCRMSG

NUTM2E

56

B1AL46
PLPMRFLQCPPDLTG

PIGB

451

Q92521
MLPNVGSPPLPFRKC

TMEM80

1

Q96HE8
SCPQLPPRDSPRCLM

PPARGC1B

561

Q86YN6
CPTPAPGLLSLSCML

SKIV2L

201

Q15477
PLPRCALCLINMGTP

MIOS

781

Q9NXC5
PCMLPVRCVPAPATL

SOWAHA

216

Q2M3V2
PPICLGRAPGCLMPA

ERVK-10

921

P10266
VRCPNNPSCPPLLRM

TRAF7

231

Q6Q0C0
PPICLGRAPGCLMPT

ERVK-11

921

Q9UQG0
MLLCSSPDRPPRCPL

PRRT4

816

C9JH25