Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR2	1.31e-05	4	30	2	GO:0005219
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR2	3.26e-05	6	30	2	GO:0048763
GeneOntologyMolecularFunction	channel activity	CLIC6 PANX2 TSPOAP1 RYR1 RYR2 TMEM175	1.11e-04	525	30	6	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CLIC6 PANX2 TSPOAP1 RYR1 RYR2 TMEM175	1.13e-04	526	30	6	GO:0022803
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR1 RYR2	3.29e-04	18	30	2	GO:0015278
GeneOntologyMolecularFunction	monoatomic ion channel activity	CLIC6 TSPOAP1 RYR1 RYR2 TMEM175	5.57e-04	459	30	5	GO:0005216
GeneOntologyMolecularFunction	calcium channel activity	TSPOAP1 RYR1 RYR2	9.41e-04	129	30	3	GO:0005262
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	RYR1 RYR2	9.88e-04	31	30	2	GO:0099604
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	RYR1 RYR2	1.12e-03	33	30	2	GO:0005217
GeneOntologyMolecularFunction	protein phosphatase 1 binding	PPP1R15A PPP1R3E	1.26e-03	35	30	2	GO:0008157
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	TSPOAP1 RYR1 RYR2	1.48e-03	151	30	3	GO:0015085
GeneOntologyMolecularFunction	monoatomic cation channel activity	TSPOAP1 RYR1 RYR2 TMEM175	1.65e-03	343	30	4	GO:0005261
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	TSPOAP1 RYR1	2.17e-03	46	30	2	GO:0005245
GeneOntologyMolecularFunction	basal RNA polymerase II transcription machinery binding	SCAF1 ZNHIT6	4.41e-03	66	30	2	GO:0001099
GeneOntologyMolecularFunction	basal transcription machinery binding	SCAF1 ZNHIT6	4.41e-03	66	30	2	GO:0001098
GeneOntologyMolecularFunction	calmodulin binding	OBSCN RYR1 RYR2	4.87e-03	230	30	3	GO:0005516
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	TSPOAP1 RYR1 RYR2 TMEM175	4.92e-03	465	30	4	GO:0046873
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	CLIC6 TSPOAP1 RYR1 RYR2 TMEM175	5.04e-03	758	30	5	GO:0015318
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CLIC6 TSPOAP1 RYR1 RYR2 TMEM175	6.09e-03	793	30	5	GO:0015075
GeneOntologyCellularComponent	junctional sarcoplasmic reticulum membrane	RYR1 RYR2	9.51e-05	10	31	2	GO:0014701
GeneOntologyCellularComponent	protein phosphatase type 1 complex	PPP1R15A PPP1R3E	3.58e-04	19	31	2	GO:0000164
GeneOntologyCellularComponent	Z disc	OBSCN RYR1 RYR2	1.43e-03	151	31	3	GO:0030018
GeneOntologyCellularComponent	I band	OBSCN RYR1 RYR2	1.88e-03	166	31	3	GO:0031674
GeneOntologyCellularComponent	sarcoplasmic reticulum membrane	RYR1 RYR2	2.03e-03	45	31	2	GO:0033017
GeneOntologyCellularComponent	smooth endoplasmic reticulum	RYR1 RYR2	2.12e-03	46	31	2	GO:0005790
GeneOntologyCellularComponent	A band	OBSCN RYR2	2.69e-03	52	31	2	GO:0031672
GeneOntologyCellularComponent	sarcolemma	OBSCN RYR1 RYR2	2.75e-03	190	31	3	GO:0042383
GeneOntologyCellularComponent	protein serine/threonine phosphatase complex	PPP1R15A PPP1R3E	3.01e-03	55	31	2	GO:0008287
GeneOntologyCellularComponent	phosphatase complex	PPP1R15A PPP1R3E	3.01e-03	55	31	2	GO:1903293
GeneOntologyCellularComponent	extrinsic component of cytoplasmic side of plasma membrane	RYR1 RYR2	3.12e-03	56	31	2	GO:0031234
GeneOntologyCellularComponent	vesicle tethering complex	VPS51 TRAPPC12	5.10e-03	72	31	2	GO:0099023
GeneOntologyCellularComponent	calcium channel complex	RYR1 RYR2	5.24e-03	73	31	2	GO:0034704
GeneOntologyCellularComponent	sarcomere	OBSCN RYR1 RYR2	5.87e-03	249	31	3	GO:0030017
GeneOntologyCellularComponent	sarcoplasmic reticulum	RYR1 RYR2	7.53e-03	88	31	2	GO:0016529
GeneOntologyCellularComponent	myofibril	OBSCN RYR1 RYR2	7.56e-03	273	31	3	GO:0030016
MousePheno	abnormal sarcoplasmic reticulum morphology	OBSCN RYR1 RYR2	6.74e-06	23	23	3	MP:0004088
MousePheno	ventricular tachycardia	OBSCN RBM20 RYR2	7.70e-06	24	23	3	MP:0008950
MousePheno	ventricular fibrillation	RBM20 RYR2	5.41e-05	7	23	2	MP:0006110
MousePheno	atrial fibrillation	RBM20 RYR2	1.16e-04	10	23	2	MP:0008543
MousePheno	irregular heartbeat	OBSCN RBM20 RYR2	2.07e-04	71	23	3	MP:0001636
MousePheno	fibrillation	RBM20 RYR2	2.33e-04	14	23	2	MP:0006109
MousePheno	abnormal myocardial fiber physiology	OBSCN RBM20 RYR2	4.16e-04	90	23	3	MP:0004215
MousePheno	abnormal muscle fiber morphology	OBSCN ABL1 RBM20 RYR1 RYR2	4.40e-04	406	23	5	MP:0004087
MousePheno	lens vacuoles	NHS FOXE3	4.83e-04	20	23	2	MP:0011697
Domain	RyR	RYR1 RYR2	7.99e-06	3	31	2	PF02026
Domain	Ryanodine_rcpt	RYR1 RYR2	7.99e-06	3	31	2	IPR003032
Domain	RR_TM4-6	RYR1 RYR2	7.99e-06	3	31	2	PF06459
Domain	Ryanrecept_TM4-6	RYR1 RYR2	7.99e-06	3	31	2	IPR009460
Domain	Ryan_recept	RYR1 RYR2	7.99e-06	3	31	2	IPR013333
Domain	RIH_assoc	RYR1 RYR2	3.98e-05	6	31	2	PF08454
Domain	RIH_assoc-dom	RYR1 RYR2	3.98e-05	6	31	2	IPR013662
Domain	RYDR_ITPR	RYR1 RYR2	3.98e-05	6	31	2	PF01365
Domain	RIH_dom	RYR1 RYR2	3.98e-05	6	31	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR2	3.98e-05	6	31	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR2	3.98e-05	6	31	2	IPR015925
Domain	Ins145_P3_rec	RYR1 RYR2	3.98e-05	6	31	2	PF08709
Domain	-	RYR1 RYR2	3.98e-05	6	31	2	1.25.10.30
Domain	MIR	RYR1 RYR2	1.19e-04	10	31	2	PS50919
Domain	MIR	RYR1 RYR2	1.19e-04	10	31	2	PF02815
Domain	MIR	RYR1 RYR2	1.19e-04	10	31	2	SM00472
Domain	MIR_motif	RYR1 RYR2	1.19e-04	10	31	2	IPR016093
Domain	EF-hand_8	RYR1 RYR2	1.45e-03	34	31	2	PF13833
Domain	SH3	OBSCN ABL1 TSPOAP1	5.40e-03	216	31	3	PS50002
Domain	SH3	OBSCN ABL1 TSPOAP1	5.40e-03	216	31	3	SM00326
Domain	SH3_domain	OBSCN ABL1 TSPOAP1	5.68e-03	220	31	3	IPR001452
Domain	SPRY	RYR1 RYR2	9.14e-03	87	31	2	SM00449
Domain	SPRY	RYR1 RYR2	1.06e-02	94	31	2	PF00622
Domain	SPRY_dom	RYR1 RYR2	1.06e-02	94	31	2	IPR003877
Domain	B30.2/SPRY	RYR1 RYR2	1.08e-02	95	31	2	IPR001870
Domain	B302_SPRY	RYR1 RYR2	1.08e-02	95	31	2	PS50188
Domain	PROTEIN_KINASE_TYR	OBSCN ABL1	1.13e-02	97	31	2	PS00109
Domain	Tyr_kinase_AS	OBSCN ABL1	1.13e-02	97	31	2	IPR008266
Domain	Ion_trans_dom	RYR1 RYR2	1.53e-02	114	31	2	IPR005821
Domain	Ion_trans	RYR1 RYR2	1.53e-02	114	31	2	PF00520
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	RYR1 RYR2	8.41e-05	11	18	2	M47958
Pathway	WP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING	RYR1 RYR2	1.19e-04	13	18	2	M39589
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	RYR1 RYR2	2.60e-04	19	18	2	M47760
Pathway	REACTOME_MYOGENESIS	MEF2B ABL1	4.18e-04	24	18	2	MM15174
Pathway	REACTOME_MYOGENESIS	MEF2B ABL1	6.13e-04	29	18	2	M853
Pubmed	Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.	RYR1 RYR2	8.73e-07	2	33	2	30542613
Pubmed	Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.	RYR1 RYR2	8.73e-07	2	33	2	15280431
Pubmed	Expression of the ryanodine receptor isoforms in immune cells.	RYR1 RYR2	8.73e-07	2	33	2	11673493
Pubmed	B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.	RYR1 RYR2	8.73e-07	2	33	2	11673462
Pubmed	Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.	RYR1 RYR2	8.73e-07	2	33	2	17259277
Pubmed	Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.	RYR1 RYR2	8.73e-07	2	33	2	25370123
Pubmed	Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.	RYR1 RYR2	8.73e-07	2	33	2	15033925
Pubmed	Ryanodine receptor oligomeric interaction: identification of a putative binding region.	RYR1 RYR2	8.73e-07	2	33	2	14722100
Pubmed	Structural and functional interactions within ryanodine receptor.	RYR1 RYR2	8.73e-07	2	33	2	26009179
Pubmed	Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.	RYR1 RYR2	8.73e-07	2	33	2	18618700
Pubmed	Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.	RYR1 RYR2	8.73e-07	2	33	2	32899693
Pubmed	Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.	RYR1 RYR2	2.62e-06	3	33	2	23278119
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR2	2.62e-06	3	33	2	9242641
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR2	2.62e-06	3	33	2	18403125
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR2	2.62e-06	3	33	2	22948152
Pubmed	Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.	RYR1 RYR2	2.62e-06	3	33	2	23454728
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR2	2.62e-06	3	33	2	10788707
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR2	2.62e-06	3	33	2	18434746
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR2	2.62e-06	3	33	2	25239916
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR2	2.62e-06	3	33	2	7621815
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR2	2.62e-06	3	33	2	9204703
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR1 RYR2	2.62e-06	3	33	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR1 RYR2	2.62e-06	3	33	2	11159936
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR2	2.62e-06	3	33	2	7876312
Pubmed	c-Abl links APP-BACE1 interaction promoting APP amyloidogenic processing in Niemann-Pick type C disease.	BACE1 ABL1	2.62e-06	3	33	2	27565738
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR2	2.62e-06	3	33	2	21881589
Pubmed	Intracellular calcium release channel expression during embryogenesis.	RYR1 RYR2	2.62e-06	3	33	2	9986730
Pubmed	Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells.	RYR1 RYR2	2.62e-06	3	33	2	24123915
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR2	2.62e-06	3	33	2	10473538
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR1 RYR2	2.62e-06	3	33	2	7959768
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR2	2.62e-06	3	33	2	12213830
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR1 RYR2	2.62e-06	3	33	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR1 RYR2	2.62e-06	3	33	2	7635066
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR1 RYR2	5.23e-06	4	33	2	9384575
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR1 RYR2	5.23e-06	4	33	2	18206662
Pubmed	Increase of ryanodine receptors by dopamine D1 receptors is negatively regulated by γ-aminobutyric acid type B receptors in primary cultures of mouse cerebral cortical neurons.	RYR1 RYR2	5.23e-06	4	33	2	22504960
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 RYR2	5.23e-06	4	33	2	9607712
Pubmed	S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex.	RYR1 RYR2	5.23e-06	4	33	2	27226555
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	RYR1 RYR2	5.23e-06	4	33	2	19120137
Pubmed	FKBP binding characteristics of cardiac microsomes from diverse vertebrates.	RYR1 RYR2	5.23e-06	4	33	2	11237759
Pubmed	Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+ release.	RYR1 RYR2	5.23e-06	4	33	2	23992453
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR1 RYR2	5.23e-06	4	33	2	23482488
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 RYR2	5.23e-06	4	33	2	23413940
Pubmed	Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction.	RYR1 RYR2	8.72e-06	5	33	2	22939628
Pubmed	Intracellular calcium-release channels: regulators of cell life and death.	RYR1 RYR2	8.72e-06	5	33	2	9124414
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR1 RYR2	8.72e-06	5	33	2	19011160
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR1 RYR2	8.72e-06	5	33	2	23918386
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR1 RYR2	1.31e-05	6	33	2	19549818
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR1 RYR2	1.31e-05	6	33	2	19009018
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR1 RYR2	1.31e-05	6	33	2	26025922
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 RYR2	1.31e-05	6	33	2	23463619
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 RYR2	1.31e-05	6	33	2	16844763
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR1 RYR2	1.31e-05	6	33	2	14592808
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 RYR2	1.31e-05	6	33	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 RYR2	1.31e-05	6	33	2	25966694
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 RYR2	1.83e-05	7	33	2	11860456
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	RYR1 RYR2	1.83e-05	7	33	2	20962236
Pubmed	Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.	RYR1 RYR2	2.44e-05	8	33	2	11784029
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR1 RYR2	2.44e-05	8	33	2	19033399
Pubmed	AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.	RYR1 RYR2	3.91e-05	10	33	2	18434328
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	RYR1 RYR2	5.73e-05	12	33	2	19095005
Pubmed	MED12 regulates a transcriptional network of calcium-handling genes in the heart.	RYR1 RYR2	7.89e-05	14	33	2	28724790
Pubmed	Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.	CLIC6 ZNHIT6	1.18e-04	17	33	2	12747765
Pubmed	Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics.	OBSCN RYR2	2.58e-04	25	33	2	38877142
Pubmed	Microphthalmia/Anophthalmia/Coloboma Spectrum – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	NHS FOXE3	4.81e-04	34	33	2	20301552
Pubmed	Hypertrophic Cardiomyopathy Overview	OBSCN RYR2	4.81e-04	34	33	2	20301725
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	OBSCN TBC1D16 SCAF1 ABL1 TRAPPC12 RYR1	5.39e-04	1105	33	6	35748872
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	RYR1 RYR2	6.01e-04	38	33	2	30786075
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	OBSCN SCAF1 EIF3A PPP1R3E RYR1	6.08e-04	736	33	5	29676528
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	SCAF1 ZNF428 PPP1R15A EID2 RYR1	1.52e-03	1192	33	5	chr19q13
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR2	3.14e-06	3	19	2	287
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PPP1R15A PPP1R3E RYR1	8.50e-04	181	19	3	694
GeneFamily	Fibronectin type III domain containing	OBSCN TSPOAP1	1.21e-02	160	19	2	555
ToppCell	RV-03._Atrial_Cardiomyocyte\|RV / Chamber and Cluster_Paper	OBSCN RBM20 EID2 RYR2	1.09e-06	105	33	4	49e16b11f16e83a7d17d162c14bce991201bcc2a
ToppCell	RV-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	OBSCN RBM20 EID2 RYR2	1.98e-06	122	33	4	1cb1dd03b2aaedbe04f3ed907568c3b7f54767b3
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C17orf50 TSPOAP1 PPP1R3E RYR2	6.57e-06	165	33	4	6d315e0734079ad05336cc2c3f24d870c9105bc8
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C17orf50 TSPOAP1 PPP1R3E RYR2	6.57e-06	165	33	4	84f5597b1bb75f42de9a224196bb8ac198bbe3bf
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	OBSCN RBM20 RYR2 TMEM175	7.39e-06	170	33	4	da4fb1e186e9bec6bba0b25f2a0e68f9e11c6017
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	OBSCN RBM20 RYR2 TMEM175	7.39e-06	170	33	4	cb1ed6bd409ee1cf11be0d5e7cdcffe2ab220d38
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZBTB46 INAFM2 FOXE3	1.84e-04	150	33	3	8645b9c7f9511ed6cc9afe04440c2873a3094150
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	BACE1 SOWAHC ZNF513	2.07e-04	156	33	3	5b2781d38a83b4b0f8a53cf321ce5db3a07d0818
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	BACE1 SOWAHC ZNF513	2.07e-04	156	33	3	e0aef6104be16b12304b8e30358f444c1660e92f
ToppCell	Globus_pallidus-Neuronal-Excitatory\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CLIC6 SMPD3 RYR1	2.23e-04	160	33	3	f843287ed57d2d5a3b3f6dfb03b6934e330e6645
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CLIC6 SMPD3 RYR1	2.27e-04	161	33	3	ebcd5066e82b7760b9da6adc02d11258d1309dab
ToppCell	RSV-Healthy-6\|RSV / Virus stimulation, Condition and Cluster	OBSCN NHS TSPOAP1	2.39e-04	164	33	3	ab312b8c2f828ea7331f2a340c4df81587a23b5c
ToppCell	RSV-Healthy-6\|Healthy / Virus stimulation, Condition and Cluster	OBSCN NHS TSPOAP1	2.39e-04	164	33	3	1b9c5a6dc4e09b90f92e98b81a5ee620f8479cc7
ToppCell	facs-Marrow-T_cells-18m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C17orf50 TSPOAP1 PPP1R3E	2.57e-04	168	33	3	260c768468dff51888f7a68e5424bb174dbaa759
ToppCell	facs-Marrow-T_cells-18m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C17orf50 TSPOAP1 PPP1R3E	2.57e-04	168	33	3	18d7719a76620d5e5698f9ffd08b4ad4cb7c13f8
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D16 SOWAHC RYR1	2.61e-04	169	33	3	735655e75511c5c41aca667909e8bb52a0ad7fc6
ToppCell	COVID-19-Heart-CM_+_Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OBSCN RBM20 RYR2	2.66e-04	170	33	3	3f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCell	COVID-19-Heart-CM_+_Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	OBSCN RBM20 RYR2	2.66e-04	170	33	3	4232fe937909f93d3736988c707b8f95ce993398
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NHS ZBTB46 RYR2	2.71e-04	171	33	3	a4a2c5dc995589fbe3d4ca6ee1df888807e4ae34
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	2.75e-04	172	33	3	bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	2.75e-04	172	33	3	ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TSPOAP1 PPP1R3E TDRP	2.75e-04	172	33	3	1aecc98a3eadabae0f1f328091a9733d916017ec
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NHS RBM20 RYR2	2.80e-04	173	33	3	cb6389536195443633adb06e5f1b7483530773d1
ToppCell	Adult-Mesenchymal-pericyte_cell-D175\|Adult / Lineage, Cell type, age group and donor	OBSCN ZBTB46 RYR2	2.80e-04	173	33	3	fd6653d6be9ca6ac36798590694efe03cb758c67
ToppCell	droplet-Heart-4Chambers-21m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	2.85e-04	174	33	3	f098778ea74012861ec74b425e45776a31f67679
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NHS RBM20 RYR2	2.85e-04	174	33	3	015d3742d3d79a57413a333f00ef2d380a9848dd
ToppCell	COVID-19-Heart-CM_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OBSCN RBM20 RYR2	2.95e-04	176	33	3	9df7a124ebafb0087da0cda133a394275d7bed81
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-2\|TCGA-Endometrium / Sample_Type by Project: Shred V9	TRAPPC12 SYCE1L TMEM175	2.95e-04	176	33	3	179b1778e8f6c4cd777cec971960211e7ba5d84a
ToppCell	Control-Fibroblasts-Airway_smooth_muscle\|Control / group, cell type (main and fine annotations)	NHS RBM20 RYR2	3.15e-04	180	33	3	d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OBSCN RBM20 RYR2	3.20e-04	181	33	3	719eb532453ab7cd7893726885bc75d74a10b21e
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	OBSCN RBM20 RYR2	3.25e-04	182	33	3	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-naive_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BACE1 C17orf50 TSPOAP1	3.25e-04	182	33	3	8b16a13d8606d21a7a9ce1175237e9b4cf832ee0
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	OBSCN RBM20 RYR2	3.35e-04	184	33	3	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	Control-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	ZBTB46 ABL1 TSPOAP1	3.35e-04	184	33	3	c6affa0b12510363258f65e46bf2d47bf4a8e75f
ToppCell	COPD-Myeloid-cDC1\|World / Disease state, Lineage and Cell class	ZBTB46 ABL1 TSPOAP1	3.35e-04	184	33	3	42d7ce104cd7bcb83fbbbd0e7d3267ad07edfa94
ToppCell	COVID-19-Heart-CM_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OBSCN RBM20 RYR2	3.35e-04	184	33	3	e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Hematopoietic\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	INAFM2 RYR2 TDRP	3.41e-04	185	33	3	9bff336510c80cd762b4e41b4570475033e709ca
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OBSCN RBM20 RYR2	3.41e-04	185	33	3	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	INAFM2 RYR2 TDRP	3.41e-04	185	33	3	452d49c7835a4d55e41caefa44dac5cab30e7ced
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Hematopoietic-Megakaryocytic-Megakaryocyte\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	INAFM2 RYR2 TDRP	3.41e-04	185	33	3	53f5136ee1bd101dd5ac8a2c9e63b0c3b987657e
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	OBSCN RBM20 RYR2	3.41e-04	185	33	3	6baccb26f999145e51b91d94315bf8d4655bef31
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Hematopoietic-Megakaryocytic\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	INAFM2 RYR2 TDRP	3.41e-04	185	33	3	67ac5c2bacdbdcb40ee65c44da55b3f597b410ee
ToppCell	Control-Myeloid-cDC1\|World / Disease state, Lineage and Cell class	ZBTB46 ABL1 TSPOAP1	3.46e-04	186	33	3	3de803dee3ef10eb85a2b47d3f93385214e5b0ff
ToppCell	IPF-Myeloid-cDC1\|World / Disease state, Lineage and Cell class	ZBTB46 ABL1 TSPOAP1	3.46e-04	186	33	3	962c2dada19185628ead77c32fcb07fa95114247
ToppCell	Control-Myeloid-cDC1\|Control / Disease state, Lineage and Cell class	ZBTB46 ABL1 TSPOAP1	3.46e-04	186	33	3	b05c394aa3573ba855abc3066739ca193883b0c3
ToppCell	facs-Heart-Unknown-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	3.52e-04	187	33	3	0ffb988e0da2c7205c3515eca8e9851739bff5c5
ToppCell	facs-Heart-Unknown\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	3.52e-04	187	33	3	362e56426a568423a81e8a30e3ecf99b76135843
ToppCell	COVID-19-Fibroblasts-Airway_smooth_muscle\|COVID-19 / group, cell type (main and fine annotations)	NHS RBM20 RYR2	3.52e-04	187	33	3	464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCell	facs-Heart-Unknown-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	3.52e-04	187	33	3	c004567767b89f3d89f5c7b28d952f3445957e1e
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	OBSCN RBM20 RYR2	3.57e-04	188	33	3	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	3.57e-04	188	33	3	90dc0e15798d0b984518ad58c7e416e30aff687a
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	3.57e-04	188	33	3	f63dfd076ced81013918363282ae25cbbd8948ae
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	3.57e-04	188	33	3	0554d542149cef654ff1e5e32dfbffd8990b52bd
ToppCell	IPF-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	ZBTB46 ABL1 TSPOAP1	3.57e-04	188	33	3	47bb6caf84f70a1cda7d09803afdfd5182772e66
ToppCell	IPF-Myeloid-cDC1\|IPF / Disease state, Lineage and Cell class	ZBTB46 ABL1 TSPOAP1	3.57e-04	188	33	3	2331a2bae1383820d598e93aa86c75b101069bac
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|RV / Chamber and Cluster_Paper	OBSCN RBM20 RYR2	3.63e-04	189	33	3	9c1debd65c13d63fd4f3158917d621b44b714c26
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	OBSCN RBM20 RYR2	3.63e-04	189	33	3	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	facs-Heart-LA/RA\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	3.63e-04	189	33	3	efa913d9c16fc32166b484d92b6449e8a0c59e03
ToppCell	facs-Heart-LA/RA-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	3.63e-04	189	33	3	a08b2d0fa35ffa510050ecffdc68e1b79bbe1632
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	OBSCN RBM20 RYR2	3.63e-04	189	33	3	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	OBSCN RBM20 RYR2	3.68e-04	190	33	3	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	OBSCN RBM20 RYR2	3.68e-04	190	33	3	de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell	COVID-19-Heart\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OBSCN RBM20 RYR2	3.68e-04	190	33	3	918ad5037881212008f9f69d5df5da91fd01422c
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NHS RBM20 RYR2	3.68e-04	190	33	3	d6b3a92119b210974a32af3fe9875d60eb02761e
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	OBSCN RBM20 RYR2	3.68e-04	190	33	3	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|LV / Chamber and Cluster_Paper	OBSCN RBM20 RYR2	3.74e-04	191	33	3	25f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCell	droplet-Heart-nan-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	3.74e-04	191	33	3	97fb4232417a39801e87725755fd16a57c250209
ToppCell	Mesenchymal-vascular_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	NHS RBM20 RYR2	3.74e-04	191	33	3	fd89fbc62aa1c73e0f659991e3bd726a0c97bd68
ToppCell	COPD-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	ZBTB46 ABL1 TSPOAP1	3.74e-04	191	33	3	3480e6d27dd4291765bbbb2acdb6a2e4f02c8085
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	OBSCN RBM20 RYR2	3.74e-04	191	33	3	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	droplet-Heart-nan-3m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	3.74e-04	191	33	3	64070a309d7e3f6001272409ab9ce206d0e7d73f
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	3.74e-04	191	33	3	715f5b449b8e075959c05a5b38389df319663164
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	3.74e-04	191	33	3	c172c9e17b893b290e4aa8af5e5e4cd3e4818372
ToppCell	COPD-Myeloid-cDC1\|COPD / Disease state, Lineage and Cell class	ZBTB46 ABL1 TSPOAP1	3.80e-04	192	33	3	bd3d00b094d92463b06023361a71240851a542b8
ToppCell	droplet-Heart-nan-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	3.80e-04	192	33	3	1a0c25106ae08eac912a4edd5fc1a3ee776f69c2
ToppCell	droplet-Heart-nan-18m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	3.80e-04	192	33	3	0bf99e029a06151092db1e8a0dcb45f4e688e771
ToppCell	droplet-Heart-nan-24m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	3.80e-04	192	33	3	f6a4e348406a852ace9fb21db8fbdff539217645
ToppCell	Control-Epithelial-Club\|Control / Disease state, Lineage and Cell class	NHS CLIC6 TDRP	3.80e-04	192	33	3	d84ed1ea4a03edaa18c804f75afb03bd7b1f0e16
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	OBSCN RBM20 RYR2	3.80e-04	192	33	3	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	droplet-Heart-nan-18m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	3.80e-04	192	33	3	d766221acfce30cbf2c60b3ae40f6744968b952c
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	OBSCN RBM20 RYR2	3.86e-04	193	33	3	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	RA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	OBSCN RBM20 RYR2	3.92e-04	194	33	3	89812fb164065041357bb37a3c2d87028ec3de4e
ToppCell	RA-03._Atrial_Cardiomyocyte\|RA / Chamber and Cluster_Paper	OBSCN RBM20 RYR2	3.92e-04	194	33	3	c3535f7cc0076653c72db582047cff053c322397
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	OBSCN RBM20 RYR2	3.97e-04	195	33	3	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	(1)_T_cells-(1)_T_CD4_naive\|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	NHS ZNHIT6 PPP1R3E	3.97e-04	195	33	3	d3fa551bc6f5ee5890af1040415e61ecd5d46201
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	OBSCN RBM20 RYR2	3.97e-04	195	33	3	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	4.03e-04	196	33	3	fba52a4b82086dbae9a55038bf44c4539be926f5
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN RBM20 RYR2	4.03e-04	196	33	3	a582130862bee76c0385156a333bfdfc75cf218b
ToppCell	COVID-19-Heart-Mito_CM\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OBSCN RBM20 RYR2	4.09e-04	197	33	3	44e49943d62bfe622b40ad0460093d31540544df
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NHS CLIC6 ZNHIT6	4.28e-04	200	33	3	b992eeddee38e6fe3564e9b1850f6b20b89bf47d
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NHS RBM20 RYR2	4.28e-04	200	33	3	a66449b22b39dd6987fc2c3ed160d24564234ced
ToppCell	Control_saline-Mesenchymal_myocytic-Pericyte-Pericyte_3\|Control_saline / Treatment groups by lineage, cell group, cell type	MEF2B PPP1R15A RYR2	4.28e-04	200	33	3	b0866b497aa71d06cef25f9a335fa584e95fa7e0
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_submucosal-gland\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	NHS CLIC6 SYCE1L	4.28e-04	200	33	3	68b0f987c4fb8078675475f4f1e71302f832ef69
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Duct\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	NHS CLIC6 SYCE1L	4.28e-04	200	33	3	1b527bebbca1ef8c52449e40beb9358e37494e04
Drug	FPL 64176	VPS51 RYR1 RYR2	1.25e-06	15	33	3	CID000003423
Drug	2-hydroxyheptanoic acid	RYR1 RYR2	6.11e-06	3	33	2	CID002750949
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR1 RYR2	6.11e-06	3	33	2	CID005748312
Drug	8N3-cADPR	RYR1 RYR2	6.11e-06	3	33	2	CID000127713
Drug	2-hydroxycarbazole	RYR1 RYR2	6.11e-06	3	33	2	CID000093551
Drug	aminodantrolene	RYR1 RYR2	6.11e-06	3	33	2	CID009570289
Drug	cis-diammineplatinum(II	RYR1 RYR2	6.11e-06	3	33	2	CID000159790
Drug	SC 38249	RYR1 RYR2	1.22e-05	4	33	2	CID000134834
Drug	AC1L1U7A	RYR1 RYR2	1.22e-05	4	33	2	CID000035682
Drug	PCB74	RYR1 RYR2	1.22e-05	4	33	2	CID000036218
Drug	148504-47-6	RYR1 RYR2	1.22e-05	4	33	2	CID006444275
Drug	A 68930	RYR1 RYR2	2.03e-05	5	33	2	ctd:C065380
Drug	AC1O528X	RYR1 RYR2	3.04e-05	6	33	2	CID006475857
Drug	4-phenylcoumarin	ABL1 PPP1R15A	3.04e-05	6	33	2	ctd:C094411
Drug	NSC114784	RYR1 RYR2	3.04e-05	6	33	2	CID000419425
Drug	MBED	RYR1 RYR2	3.04e-05	6	33	2	CID000129958
Drug	chloro-m-cresol	RYR1 RYR2	3.04e-05	6	33	2	CID000012008
Drug	Azumoleno	RYR1 RYR2	4.26e-05	7	33	2	CID000056259
Drug	[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate	RYR1 RYR2	4.26e-05	7	33	2	CID009547999
Drug	Br2BAPTA	RYR1 RYR2	4.26e-05	7	33	2	CID003081001
Drug	Cinildipine	VPS51 RYR1 RYR2	7.30e-05	56	33	3	CID000002752
Drug	Huang Qi	BACE1 RYR2	9.10e-05	10	33	2	ctd:C027492
Drug	PCB 95	RYR1 RYR2	9.10e-05	10	33	2	CID000038012
Drug	R 478	RYR1 RYR2	1.11e-04	11	33	2	CID000084223
Drug	2,3,6,2',3',6'-hexachlorobiphenyl	RYR1 RYR2	1.11e-04	11	33	2	ctd:C010498
Drug	8-amino-cADPR	RYR1 RYR2	1.11e-04	11	33	2	CID003081323
Drug	PCB 66	RYR1 RYR2	1.11e-04	11	33	2	CID000036185
Drug	tectoridin	RYR1 RYR2	1.11e-04	11	33	2	CID005281810
Drug	papaverine	SMPD3 VPS51 RYR1 RYR2	1.19e-04	176	33	4	CID000004680
Drug	Ryanodine	RYR1 RYR2	1.33e-04	12	33	2	ctd:D012433
Drug	Gvapspat amide	RYR1 RYR2	2.11e-04	15	33	2	CID000125015
Drug	kazinol B	RYR1 RYR2	2.73e-04	17	33	2	CID000480869
Drug	methylcoumarin	RYR1 RYR2	3.07e-04	18	33	2	CID000007092
Drug	AC1L380G	RYR1 RYR2	3.43e-04	19	33	2	CID000084698
Drug	AC1MW7VF	RYR1 RYR2	3.43e-04	19	33	2	CID000414699
Drug	SK&F 82958	RYR1 RYR2	3.43e-04	19	33	2	ctd:C071262
Drug	Baclofen	RYR1 RYR2	3.81e-04	20	33	2	ctd:D001418
Drug	2,2',3,5',6-pentachlorobiphenyl	RYR1 RYR2	3.81e-04	20	33	2	ctd:C032904
Drug	indo-1/AM	RYR1 RYR2	4.20e-04	21	33	2	CID000123918
Drug	tectorigenin	RYR1 RYR2	4.20e-04	21	33	2	CID005281811
Drug	loperamide	TSPOAP1 RYR1 RYR2	4.70e-04	105	33	3	CID000003954
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR2	3.42e-06	3	32	2	DOID:8545 (implicated_via_orthology)
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR2	3.42e-06	3	32	2	DOID:3529 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	OBSCN NHS ABL1 PANX2 TRAPPC12 PURG	9.22e-04	1074	32	6	C0006142
Disease	alcohol use disorder (implicated_via_orthology)	CLIC6 RYR1 RYR2	1.22e-03	195	32	3	DOID:1574 (implicated_via_orthology)
Disease	Hypertrophic Cardiomyopathy	OBSCN RYR2	1.75e-03	57	32	2	C0007194

Protein segments in the cluster

Peptide	Gene	Start	Entry
ETDEEPEEPGRRGSF	BACE1	46	P56817
EPGEDEERRERSPEG	CLIC6	366	Q96NY7
RSPEGPREEEAAGGE	CLIC6	376	Q96NY7
AELDERPEGGRPHRE	RBM20	721	Q5T481
GRSQPRPEEEDAGDE	TSPOAP1	761	O95153
RIGGEEGGRPPEADD	SMPD3	246	Q9NY59
EPDEGPEEPGEKFRR	MEF2B	101	Q02080
GEPDGPRVRVEELGE	OBSCN	151	Q5VST9
DPAGLEGGPRDESRD	ATP11AUN	36	Q6ZP68
GMDDDRGPRRGPEED	EIF3A	961	Q14152
PEPGREGVRDLAGAE	ZNHIT6	26	Q9NWK9
ERGPPEGGLNEDERL	ABL1	576	P00519
EEPPRVAEEGEGRER	C17orf50	51	Q8WW18
LLGEPVDEEGPEGRP	EID2	111	Q8N6I1
YRGVPGREEDADDPE	RYR1	3576	P21817
EVRGDGEEGERKPLE	RYR2	4341	Q92736
GRRPEEEAEDSGGPG	PPP1R15A	76	O75807
EEEDGGPRLPQDVGD	PANX2	636	Q96RD6
RRGGDDDPLELPEGT	PURG	251	Q9UJV8
GPLERPRGPDEDEEE	INAFM2	131	P0DMQ5
PGRRDLDEVEAPGPE	NHS	41	Q6T4R5
EEPEEEPGEGGTRFG	PPP1R3E	36	Q9H7J1
EPGREPEEAAAGRGE	FOXE3	36	Q13461
EGRGEEGVGEERPVK	SOWAHC	496	Q53LP3
EGEAGPELPRARDEE	SYCE1L	216	A8MT33
PEGRALGEEEEEPPR	ZNF428	126	Q96B54
LGEEEEEPPRAGEGR	ZNF428	131	Q96B54
GDSPEGPEGEAPERR	VPS51	16	Q9UID3
VEEPARGPGEARGER	ZNF513	101	Q8N8E2
DCPPGRRDEDAGEGI	TMEM175	16	Q9BSA9
RGRVLLDEPPEEEDG	TDRP	6	Q86YL5
GRVRDEAEPGGEGDP	TRAPPC12	86	Q8WVT3
TEESGEDRGDGPPDR	SCAF1	11	Q9H7N4
TEEGREPRPEAGEED	TBC1D16	196	Q8TBP0
EDPEDPRGEAEELGE	ZBTB46	536	Q86UZ6