Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	ITSN2 ARHGEF28 ARHGEF9 RGL4	1.30e-04	231	23	4	GO:0005085
GeneOntologyMolecularFunction	molecular adaptor activity	NSD1 GIGYF2 TCHH SURF6 SSX8P VCP ITSN2	6.11e-04	1356	23	7	GO:0060090
HumanPheno	Cerebral hypoplasia	NSD1 GIGYF2 VCP KIF7 HUWE1 COLGALT1 ARHGEF9	2.30e-05	844	8	7	HP:0006872
Domain	RhoGEF	ITSN2 ARHGEF28 ARHGEF9	6.76e-05	68	22	3	SM00325
Domain	DH_2	ITSN2 ARHGEF28 ARHGEF9	7.38e-05	70	22	3	PS50010
Domain	RhoGEF	ITSN2 ARHGEF28 ARHGEF9	7.38e-05	70	22	3	PF00621
Domain	-	ITSN2 ARHGEF28 ARHGEF9	7.70e-05	71	22	3	1.20.900.10
Domain	DH-domain	ITSN2 ARHGEF28 ARHGEF9	7.70e-05	71	22	3	IPR000219
Domain	WWE	PARP11 HUWE1	8.68e-05	12	22	2	PS50918
Domain	WWE-dom	PARP11 HUWE1	8.68e-05	12	22	2	IPR004170
Domain	WWE	PARP11 HUWE1	8.68e-05	12	22	2	PF02825
Domain	DH_1	ARHGEF28 ARHGEF9	2.48e-03	63	22	2	PS00741
Domain	PH	ITSN2 ARHGEF28 ARHGEF9	4.07e-03	278	22	3	SM00233
Domain	PH_DOMAIN	ITSN2 ARHGEF28 ARHGEF9	4.12e-03	279	22	3	PS50003
Domain	PH_domain	ITSN2 ARHGEF28 ARHGEF9	4.16e-03	280	22	3	IPR001849
Domain	SH3_2	ITSN2 ARHGEF9	4.56e-03	86	22	2	IPR011511
Domain	SH3_2	ITSN2 ARHGEF9	4.56e-03	86	22	2	PF07653
Domain	-	ITSN2 ARHGEF28 ARHGEF9	1.04e-02	391	22	3	2.30.29.30
Domain	PH_dom-like	ITSN2 ARHGEF28 ARHGEF9	1.31e-02	426	22	3	IPR011993
Domain	EF-hand_1	TCHH ITSN2	1.37e-02	152	22	2	PF00036
Domain	SH3_1	ITSN2 ARHGEF9	1.58e-02	164	22	2	PF00018
Domain	EF_Hand_1_Ca_BS	TCHH ITSN2	1.78e-02	175	22	2	IPR018247
Pathway	PID_CDC42_REG_PATHWAY	ITSN2 ARHGEF9	3.92e-04	30	14	2	M83
Pathway	REACTOME_EARLY_SARS_COV_2_INFECTION_EVENTS	CHMP2A VCP	5.98e-04	37	14	2	M45028
Pathway	REACTOME_RHO_GTPASE_CYCLE	VCP ITSN2 ARHGEF28 ARHGEF9	7.24e-04	439	14	4	MM15595
Pathway	REACTOME_RHO_GTPASE_CYCLE	VCP ITSN2 ARHGEF28 ARHGEF9	7.95e-04	450	14	4	M27078
Pubmed	Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation.	GIGYF2 RASIP1 EIF3D HUWE1	1.45e-07	72	23	4	36376293
Pubmed	Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress.	GIGYF2 VCP	1.25e-06	3	23	2	36288698
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	NSD1 GIGYF2 SURF6 VCP EIF3D HUWE1	3.29e-06	653	23	6	22586326
Pubmed	The role of USP7 in the Shoc2-ERK1/2 signaling axis and Noonan-like syndrome with loose anagen hair.	VCP HUWE1	6.26e-06	6	23	2	34553755
Pubmed	A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.	CHMP2A SURF6 VCP EIF3D HUWE1 COLGALT1	9.50e-06	786	23	6	29128334
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	SURF6 EIF3D ITSN2 HUWE1 ARHGEF28 ARHGEF9	2.26e-05	916	23	6	32203420
Pubmed	RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins.	VCP HUWE1	3.25e-05	13	23	2	32645369
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	PARP11 GIGYF2 VCP EIF3D KIF7 HUWE1	3.80e-05	1005	23	6	19615732
Pubmed	Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.	VCP ITSN2 HUWE1	3.80e-05	99	23	3	29676259
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	GIGYF2 RASIP1 VCP ITSN2 HUWE1	4.04e-05	604	23	5	38803224
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	CCDC61 CHMP2A SURF6 VCP EIF3D OXA1L	5.73e-05	1082	23	6	38697112
Pubmed	SHARPIN negatively associates with TRAF2-mediated NFκB activation.	NSD1 SURF6	7.10e-05	19	23	2	21829440
Pubmed	The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.	SURF6 VCP ITSN2	7.62e-05	125	23	3	29467281
Pubmed	FGF11 induced by hypoxia interacts with HIF-1α and enhances its stability.	LZTS3 VCP HUWE1	8.17e-05	128	23	3	28027390
Pubmed	Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate.	VCP COLGALT1	8.72e-05	21	23	2	23097496
Pubmed	Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway.	VCP HUWE1	1.05e-04	23	23	2	22038470
Pubmed	Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.	VCP OXA1L HUWE1 COLGALT1	1.58e-04	422	23	4	27342126
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	GIGYF2 SURF6 VCP EIF3D RAVER2	1.58e-04	807	23	5	22681889
Pubmed	ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.	VCP HUWE1 COLGALT1	1.76e-04	166	23	3	35687106
Pubmed	Global landscape of HIV-human protein complexes.	VCP EIF3D HUWE1 COLGALT1	2.14e-04	457	23	4	22190034
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	GIGYF2 VCP EIF3D OXA1L HUWE1 COLGALT1	2.49e-04	1415	23	6	28515276
Pubmed	Mutation of ARHGAP9 in patients with coronary spastic angina.	ITSN2 ARHGEF9	2.90e-04	38	23	2	19911011
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CCDC61 SURF6 VCP OXA1L KIF7 COLGALT1	3.26e-04	1487	23	6	33957083
Pubmed	A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.	SURF6 ARHGEF28	3.38e-04	41	23	2	23509962
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	LZTS3 NSD1 GIGYF2 KIF7 HUWE1	3.58e-04	963	23	5	28671696
Pubmed	A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication.	CHMP2A ITSN2 ARHGEF28	3.92e-04	218	23	3	19460752
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	GIGYF2 VCP EIF3D HUWE1	4.34e-04	551	23	4	34728620
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	GIGYF2 VCP EIF3D KIF7 HUWE1	4.74e-04	1024	23	5	24711643
Pubmed	Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain.	VCP HUWE1	5.03e-04	50	23	2	17550899
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	NSD1 GIGYF2 VCP	5.32e-04	242	23	3	34011540
Pubmed	Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.	VCP HUWE1 COLGALT1	5.44e-04	244	23	3	28902428
Pubmed	Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions.	VCP HUWE1	5.86e-04	54	23	2	34761751
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	GIGYF2 EIF3D HUWE1	5.91e-04	251	23	3	28077445
Pubmed	Ring Finger Protein 11 acts on ligand-activated EGFR via the direct interaction with the UIM region of ANKRD13 protein family.	VCP HUWE1	6.08e-04	55	23	2	31985874
Pubmed	Derlin-1 promotes ubiquitylation and degradation of the epithelial Na+ channel, ENaC.	VCP HUWE1	6.08e-04	55	23	2	28137758
Pubmed	Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome.	ITSN2 ARHGEF9	6.30e-04	56	23	2	22745667
Pubmed	Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.	VCP EIF3D COLGALT1	6.47e-04	259	23	3	31162944
Interaction	TPTE2 interactions	CCDC61 VCP KIF7 HUWE1	1.59e-06	84	21	4	int:TPTE2
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ITSN2 ARHGEF9	9.97e-04	66	13	2	722
GeneFamily	EF-hand domain containing	TCHH ITSN2	1.04e-02	219	13	2	863
Disease	3-hydroxyisobutyrate measurement	PARP11 GIGYF2	6.54e-06	6	20	2	EFO_0010983
Disease	sitting height ratio	NSD1 ITSN2	5.46e-04	51	20	2	EFO_0007118
Disease	Nasal Cavity Polyp	GIGYF2 ITSN2	6.34e-04	55	20	2	EFO_1000391
Disease	Amyotrophic Lateral Sclerosis	VCP ARHGEF28	7.05e-04	58	20	2	C0002736
Disease	Profound Mental Retardation	NSD1 KIF7	3.96e-03	139	20	2	C0020796
Disease	Mental deficiency	NSD1 KIF7	3.96e-03	139	20	2	C0917816
Disease	Mental Retardation, Psychosocial	NSD1 KIF7	3.96e-03	139	20	2	C0025363
Disease	body surface area	NSD1 GIGYF2 ITSN2	8.91e-03	643	20	3	EFO_0022196

Protein segments in the cluster

Peptide	Gene	Start	Entry
RKQREIQMKQQQRNR	CCDC61	356	Q9Y6R9
RQNQRALNRAMRELD	CHMP2A	16	O43633
VMRNVTQQINERKRR	ARHGEF9	276	O43307
RRRQQERRQQALSMA	RASIP1	336	Q5U651
ARLQRMQRELSNRRK	RAVER2	56	Q9HCJ3
QRLNQRRTKPRKRMN	NSD1	1161	Q96L73
RRQALMEQQQREAER	ITSN2	381	Q9NZM3
QRLVEREQARMRAQQ	ARHGEF28	1511	Q8N1W1
MYQRNQQLERRLRER	LZTS3	626	O60299
MRQQQGQLQRRLREE	KIF7	831	Q2M1P5
RQLREREQRMRNQLE	OXA1L	376	Q15070
IQMVREGQRARRQQQ	HUWE1	3776	Q7Z6Z7
MDRNRIKRIQRIQNL	PARP11	161	Q9NR21
QERNPQRVQMRLRRQ	RGL4	371	Q8IZJ4
MRQRQQQQEALRRLQ	GIGYF2	896	Q6Y7W6
AQRNLRRDKDRRNML	EIF3D	101	O15371
RQDRRERMLRALQAQ	COLGALT1	351	Q8NBJ5
EKMQQRQDRRRQNLR	SURF6	316	O75683
KIRMNRVVRNNLRVR	VCP	81	P55072
NDRNRRIQVERPQMT	SSX8P	86	Q7RTT4
EHNEKRQRRQERRQM	TMEM208	156	Q9BTX3
QQQRLRREQQLRRKQ	TCHH	296	Q07283
SRQRRRVQLMRIRQQ	TMEM198	251	Q66K66