Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	jerky movement	SCN1A OCA2 TRAK1	2.39e-05	20	40	3	MP:0005424
Domain	Frizzled	FZD8 FZD5	4.11e-04	11	52	2	IPR000539
Domain	Frizzled	FZD8 FZD5	4.11e-04	11	52	2	PF01534
Domain	Frizzled	FZD8 FZD5	4.11e-04	11	52	2	SM01330
Domain	GPCR_2-like	FZD8 CELSR1 FZD5	6.23e-04	60	52	3	IPR017981
Domain	G_PROTEIN_RECEP_F2_4	FZD8 CELSR1 FZD5	6.54e-04	61	52	3	PS50261
Domain	Frizzled/SFRP	FZD8 FZD5	8.90e-04	16	52	2	IPR015526
Domain	FRI	FZD8 FZD5	1.40e-03	20	52	2	SM00063
Domain	-	FZD8 FZD5	1.54e-03	21	52	2	1.10.2000.10
Domain	Frizzled_dom	FZD8 FZD5	2.02e-03	24	52	2	IPR020067
Domain	FZ	FZD8 FZD5	2.02e-03	24	52	2	PS50038
Domain	Fz	FZD8 FZD5	2.02e-03	24	52	2	PF01392
Domain	GPS	CELSR1 PKD1L3	4.03e-03	34	52	2	SM00303
Domain	GPS	CELSR1 PKD1L3	4.27e-03	35	52	2	PF01825
Domain	GPS	CELSR1 PKD1L3	4.51e-03	36	52	2	PS50221
Domain	GPS	CELSR1 PKD1L3	4.76e-03	37	52	2	IPR000203
Domain	LAM_G_DOMAIN	FAT1 CELSR1	5.01e-03	38	52	2	PS50025
Domain	Laminin_G_2	FAT1 CELSR1	5.54e-03	40	52	2	PF02210
Domain	Kinesin-like_fam	KIF15 KIF17	6.38e-03	43	52	2	IPR027640
Domain	KINESIN_MOTOR_1	KIF15 KIF17	6.67e-03	44	52	2	PS00411
Domain	-	KIF15 KIF17	6.67e-03	44	52	2	3.40.850.10
Domain	Kinesin_motor_dom	KIF15 KIF17	6.67e-03	44	52	2	IPR001752
Domain	Kinesin	KIF15 KIF17	6.67e-03	44	52	2	PF00225
Domain	KINESIN_MOTOR_2	KIF15 KIF17	6.67e-03	44	52	2	PS50067
Domain	LamG	FAT1 CELSR1	6.67e-03	44	52	2	SM00282
Domain	KISc	KIF15 KIF17	6.67e-03	44	52	2	SM00129
Pubmed	Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling.	TRIB3 SNRK	2.46e-06	2	55	2	28117339
Pubmed	Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled.	FZD8 FZD5	7.36e-06	3	55	2	11520064
Pubmed	The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine.	FZD8 PLXNA3 FZD5	8.40e-06	25	55	3	35874829
Pubmed	A secreted WNT-ligand-binding domain of FZD5 generated by a frameshift mutation causes autosomal dominant coloboma.	FZD8 FZD5	2.45e-05	5	55	2	26908622
Pubmed	LDL-receptor-related proteins in Wnt signal transduction.	FZD8 FZD5	2.45e-05	5	55	2	11029007
Pubmed	MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap.	FZD8 FZD5	5.13e-05	7	55	2	15195140
Pubmed	Wnt receptors and Wnt inhibitors are expressed in gradients in the developing telencephalon.	FZD8 FZD5	5.13e-05	7	55	2	11335128
Pubmed	Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription.	FZD8 FZD5	5.13e-05	7	55	2	11265645
Pubmed	Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).	FZD8 FZD5	5.13e-05	7	55	2	15370539
Pubmed	Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.	FZD8 FZD5	5.13e-05	7	55	2	9192640
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PLXNA3 ZNF263 FAT1 CELSR1 TRIB3 HECTD4 RGL2 ADCY9 TRAK1	5.46e-05	1105	55	9	35748872
Pubmed	Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.	FZD8 CELSR1 FZD5	5.78e-05	47	55	3	33141892
Pubmed	Differential expression of the Wnt putative receptors Frizzled during mouse somitogenesis.	FZD8 FZD5	6.83e-05	8	55	2	10559494
Pubmed	Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis.	FZD8 FZD5	1.10e-04	10	55	2	17532316
Pubmed	Expression of Frizzled genes in developing and postnatal hair follicles.	FZD8 FZD5	1.10e-04	10	55	2	15245425
Pubmed	ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.	FZD8 FZD5	1.34e-04	11	55	2	22575959
Pubmed	Molecular determinants of WNT9b responsiveness in nephron progenitor cells.	FZD8 FZD5	1.34e-04	11	55	2	30978219
Pubmed	Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.	FZD8 FZD5	1.34e-04	11	55	2	24860427
Pubmed	Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain.	FZD8 FZD5	1.34e-04	11	55	2	17582687
Pubmed	Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling.	FZD8 FZD5	1.34e-04	11	55	2	17576136
Pubmed	Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos.	FZD8 FZD5	1.89e-04	13	55	2	22266179
Pubmed	DNA cloning using in vitro site-specific recombination.	FZD8 ARL1 ZNF555 UTP15 GRM1 STRIP2 TRAK1	2.46e-04	794	55	7	11076863
Pubmed	A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.	CELSR1 HEPH	2.90e-04	16	55	2	10932191
Pubmed	Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.	FZD8 FZD5	3.29e-04	17	55	2	28733458
Pubmed	Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.	OCA2 IKZF4	4.13e-04	19	55	2	22561518
Pubmed	Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate.	FZD8 FZD5	4.13e-04	19	55	2	20890044
Pubmed	Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.	FZD8 FZD5	4.13e-04	19	55	2	21623369
Pubmed	Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.	FZD8 FZD5	5.56e-04	22	55	2	17064353
Pubmed	A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.	FZD8 FZD5	6.63e-04	24	55	2	9096311
Pubmed	A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.	FZD8 FZD5	6.63e-04	24	55	2	8626800
Pubmed	A role for Wnt/beta-catenin signaling in lens epithelial differentiation.	FZD8 FZD5	7.20e-04	25	55	2	12812787
Pubmed	Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.	KIF15 KIF17	7.20e-04	25	55	2	9275178
Pubmed	PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.	FZD8 PLXNA3 FZD5	8.57e-04	117	55	3	17145500
Pubmed	The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein.	ZNF263 ADCY9	9.70e-04	29	55	2	12438443
Pubmed	Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.	PHIP STRIP2	9.70e-04	29	55	2	21834987
Pubmed	3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).	FZD8 FZD5	9.70e-04	29	55	2	18364260
Pubmed	Regulation of retinal progenitor expansion by Frizzled receptors: implications for microphthalmia and retinal coloboma.	FZD8 FZD5	1.11e-03	31	55	2	22228100
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	ARL1 ZNF555 UTP15 FZD5 RGL2 TRAK1	1.16e-03	750	55	6	11230166
Pubmed	Secondary Placental Defects in Cxadr Mutant Mice.	FZD5 VEGFD	1.18e-03	32	55	2	31338035
Pubmed	Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation.	FZD8 FZD5	1.49e-03	36	55	2	12412008
Pubmed	Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.	FZD8 FZD5	1.49e-03	36	55	2	24151333
Pubmed	Integrated analysis of Wnt signalling system component gene expression.	FZD8 FZD5	1.58e-03	37	55	2	35831952
Pubmed	All kinesin superfamily protein, KIF, genes in mouse and human.	KIF15 KIF17	1.58e-03	37	55	2	11416179
Pubmed	Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.	FZD8 FZD5	1.58e-03	37	55	2	15342465
Pubmed	Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis.	FZD8 FZD5	1.58e-03	37	55	2	18800919
Cytoband	10q26.13	ABRAXAS2 DMBT1	9.64e-04	38	55	2	10q26.13
Cytoband	3p22.1	SNRK TRAK1	1.07e-03	40	55	2	3p22.1
GeneFamily	G protein-coupled receptors, Class F frizzled	FZD8 FZD5	1.98e-04	11	35	2	286
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF15 KIF17	3.57e-03	46	35	2	622
GeneFamily	WD repeat domain containing	FBXW8 UTP15 PHIP	1.40e-02	262	35	3	362
ToppCell	3'-GW_trimst-2-SmallIntestine\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	METTL9 CASP1 XDH DMBT1 C6orf141	4.57e-06	198	55	5	cc162ba4b3b8dec667a8cffd3411965f3f856f8c
Disease	partial epilepsy	SCN1A ADCY9	4.07e-04	17	52	2	EFO_0004263
Disease	acute kidney failure (implicated_via_orthology)	CASP1 XDH	1.04e-03	27	52	2	DOID:3021 (implicated_via_orthology)
Disease	diastolic blood pressure, unipolar depression	HECTD4 TRAK1	1.28e-03	30	52	2	EFO_0003761, EFO_0006336
Disease	unipolar depression, age at onset	GABRR2 FAT1	2.28e-03	40	52	2	EFO_0003761, EFO_0004847
Disease	interleukin 17 measurement	TRIB3 GRM1	2.87e-03	45	52	2	EFO_0008174
Disease	fibrinogen measurement, tissue plasminogen activator measurement	HECTD4 PKD1L3	2.87e-03	45	52	2	EFO_0004623, EFO_0004791
Disease	fibrinogen measurement, plasminogen activator inhibitor 1 measurement	HECTD4 PKD1L3	2.87e-03	45	52	2	EFO_0004623, EFO_0004792
Disease	myocardial infarction	SEC24D HECTD4 DMBT1 PKD1L3	3.36e-03	350	52	4	EFO_0000612

Protein segments in the cluster

Peptide	Gene	Start	Entry
DSVFTSMFHSVRRVL	URB2	1196	Q14146
HISADRMFELLFTSS	GRAMD1C	336	Q8IYS0
QESTLSHSRMERSVF	ABRAXAS2	316	Q15018
AFRSHTFSEQTLMST	CREBRF	16	Q8IUR6
SSIFSSLFGTREMRI	ARL1	6	P40616
SHTASFAVLMDISRR	CELSR1	2446	Q9NYQ6
LDSMFSHSIRNFTET	SLC7A4	141	O43246
RRSEHSVMSRTFEVL	OCA2	281	Q04671
SVSAMSRFTAARLEF	GSG1L2	221	A8MUP6
ESVMSTHSTARLSFV	FAT1	3756	Q14517
STSMNRESSRSHAVF	KIF15	226	Q9NS87
TVMRNADLDSFTTHR	FBXW8	536	Q8N3Y1
FIHTLEAQSSFSMRD	PLXNA3	1346	P51805
SVDSIIRSFIHESSM	CSPP1	901	Q1MSJ5
IRSFIHESSMSRAQS	CSPP1	906	Q1MSJ5
HESRSMRIFSTESLL	LAX1	106	Q8IWV1
HSFVSSVFSLFMSRT	METTL9	101	Q9H1A3
DTVTFSFEMRSGREH	HECTD4	731	Q9Y4D8
MDFSRRSFHRSLSSS	KRT20	1	P35900
MSHRTSSTFRAERSF	HSPB7	1	Q9UBY9
STTVATFLIDMERFR	FZD5	251	Q13467
STFATVSTFLIDMER	FZD8	291	Q9H461
TSDSTFLVFMSHGIR	CASP1	226	P29466
MTTRTEEHFVTALTF	C6orf141	181	Q5SZD1
RFSKFRVHESMRIST	HYAL4	276	Q2M3T9
VHLFVMSQVRSRSTF	ADCY9	296	O60503
TFSSIARVRMEEHFI	KLHDC7A	261	Q5VTJ3
VRSAFTTSDVVRMHV	GRM1	846	Q13255
SSNFMSIRFISDHSI	DMBT1	2091	Q9UGM3
SMLHSSSERPTFIDR	IKZF4	301	Q9H2S9
SFTHDTTTDNIMLRV	GABRR2	146	P28476
DSSRSHSIFTISIEM	KIF17	206	Q9P2E2
MSLSASHVSSFRRHF	RNF139	376	Q8WU17
FHTSFDMMLRLTSIF	TAAR3P	106	Q9P1P4
MFDARTSESVLSVEH	UTP15	191	Q8TED0
GTDVSFMSAFLATHR	RGL2	111	O15211
FMSAFLATHRAFTST	RGL2	116	O15211
TARETFRTELSFSMH	STRIP2	226	Q9ULQ0
METLFTVFSRTEHLS	HEPH	1056	Q9BQS7
ELFSFRHLFSSMIVE	PKD1L3	866	Q7Z443
ERSQREMFFTTMESH	SIMC1	701	Q8NDZ2
VVFDSMRKHDGSTFR	SKIV2L	676	Q15477
FFSDHMADTTTELER	SNRK	706	Q9NRH2
MRVRTSTGFRATDFF	SEC24D	691	O94855
ETEMRKRRSSSFHVS	SCN1A	686	P35498
KRRSSSFHVSMDFLE	SCN1A	691	P35498
LFSIEVMSSHFSVRD	CLCNKA	221	P51800
TESIMSLGTHSRFSE	TRAK1	541	Q9UPV9
EAFSYSSTFRRHMIS	ZNF555	291	Q8NEP9
MSLRLSAFFEEHISS	PHIP	1406	Q8WWQ0
TTVRREFMDHSISPF	SULT1A2	241	P50226
FFTRTHGDMHSLVRS	TRIB3	136	Q96RU7
SFPRSFHERSSNMLS	SPATA31D1	751	Q6ZQQ2
SRGTRRTVQMDHTFF	XDH	376	P47989
FSCSSSFRMHERTHT	ZNF709	401	Q8N972
SFSSSFRMHERTHTG	ZNF709	486	Q8N972
TFTVLRAFGSVSMAH	MYO18B	696	Q8IUG5
FFMSTTESISEFILR	TARBP1	721	Q13395
SMDSRSASHRSTRFA	VEGFD	76	O43915
ESFSRSSRLMSHQRT	ZNF263	666	O14978