Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1A CACNA1B CACNA1D CACNA1H

3.55e-06141584GO:0008331
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1A CACNA1B CACNA1D CACHD1 CACNA1H

3.07e-05461585GO:0005245
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of cytosolic calcium levels

CACNA1A CACNA1B CACNA1D

3.94e-0591583GO:0099511
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

CACNA1A CACNA1B CACNA1D

3.94e-0591583GO:0099626
GeneOntologyMolecularFunctionRNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity

NANOGP8 NANOG

3.69e-0441582GO:0001010
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1A CACNA1B CACNA1D CACHD1 PKDREJ CACNA1H

5.70e-041291586GO:0005262
GeneOntologyMolecularFunction2'-5'-oligoadenylate synthetase activity

OAS2 OAS3

6.13e-0451582GO:0001730
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1A CACNA1B CACNA1D CACHD1 CACNA1H

2.32e-05461565GO:0005891
GeneOntologyCellularComponentcalcium channel complex

CACNA1A CACNA1B CACNA1D CACHD1 CACNA1H

2.17e-04731565GO:0034704
GeneOntologyCellularComponenttranscription factor TFTC complex

TAF9B TAF2 TAF9

3.06e-04181563GO:0033276
GeneOntologyCellularComponentcation channel complex

CACNA1A CACNA1B CACNA1D CACHD1 SCN7A KCNJ16 SCNN1B CACNA1H

3.94e-042351568GO:0034703
DomainVDCCAlpha1

CACNA1A CACNA1B CACNA1D CACNA1H

9.95e-07101584IPR002077
DomainCa_chan_IQ

CACNA1A CACNA1B CACNA1D

2.03e-0571583SM01062
DomainCa_chan_IQ

CACNA1A CACNA1B CACNA1D

2.03e-0571583PF08763
DomainVDCC_a1su_IQ

CACNA1A CACNA1B CACNA1D

2.03e-0571583IPR014873
DomainGPHH

CACNA1A CACNA1B CACNA1D

2.03e-0571583PF16905
DomainGPHH_dom

CACNA1A CACNA1B CACNA1D

2.03e-0571583IPR031649
DomainChannel_four-helix_dom

CACNA1A CACNA1B CACNA1D SCN7A CACNA1H

1.19e-04571585IPR027359
Domain-

CACNA1A CACNA1B CACNA1D SCN7A CACNA1H

1.19e-045715851.20.120.350
DomainTFIID-31

TAF9B TAF9

2.12e-0431582IPR003162
DomainTFIID-31kDa

TAF9B TAF9

2.12e-0431582PF02291
DomainGDS_CDC24_CS

OBSCN TIAM2 ARHGEF1 PREX1

3.22e-04391584IPR001331
DomainOAS1_C

OAS2 OAS3

4.22e-0441582PF10421
Domain2-5-oligoadenylate_synth_CS

OAS2 OAS3

4.22e-0441582IPR006117
Domain25A_SYNTH_3

OAS2 OAS3

4.22e-0441582PS50152
Domain2-5-oligoAdlate_synth_1_dom2/C

OAS2 OAS3

4.22e-0441582IPR018952
Domain2-5A_synthase

OAS2 OAS3

4.22e-0441582IPR026774
Domain-

OAS2 OAS3

4.22e-04415821.10.1410.20
Domain25A_SYNTH_1

OAS2 OAS3

4.22e-0441582PS00832
Domain25A_SYNTH_2

OAS2 OAS3

4.22e-0441582PS00833
Domain2-5-oligoadenylate_synth_N

OAS2 OAS3

6.99e-0451582IPR006116
DomainDH_1

OBSCN TIAM2 ARHGEF1 PREX1

1.99e-03631584PS00741
DomainRhoGEF

OBSCN TIAM2 ARHGEF1 PREX1

2.64e-03681584SM00325
DomainIon_trans_dom

CACNA1A CACNA1B CACNA1D SCN7A CACNA1H

2.85e-031141585IPR005821
DomainIon_trans

CACNA1A CACNA1B CACNA1D SCN7A CACNA1H

2.85e-031141585PF00520
DomainRhoGEF

OBSCN TIAM2 ARHGEF1 PREX1

2.93e-03701584PF00621
DomainDH_2

OBSCN TIAM2 ARHGEF1 PREX1

2.93e-03701584PS50010
DomainGPS

ADGRG1 ADGRL1 PKDREJ

2.93e-03341583SM00303
DomainZP_dom_CS

ZP1 GP2

3.06e-03101582IPR017977
Domain-

OBSCN TIAM2 ARHGEF1 PREX1

3.09e-037115841.20.900.10
DomainDH-domain

OBSCN TIAM2 ARHGEF1 PREX1

3.09e-03711584IPR000219
DomainNTP_transf_2

OAS2 OAS3

3.72e-03111582PF01909
DomainPolymerase_NTP_transf_dom

OAS2 OAS3

3.72e-03111582IPR002934
DomainBAH

MTA2 MTA1

3.72e-03111582PS51038
DomainBAH_dom

MTA2 MTA1

3.72e-03111582IPR001025
DomainBAH

MTA2 MTA1

3.72e-03111582SM00439
DomainBAH

MTA2 MTA1

3.72e-03111582PF01426
DomainGPS

ADGRG1 ADGRL1 PKDREJ

3.74e-03371583IPR000203
DomainEGF_dom

CUBN STAB1

4.44e-03121582IPR024731
DomainEGF_3

CUBN STAB1

4.44e-03121582PF12947
DomainZnF_GATA

MTA2 MTA1

4.44e-03121582SM00401
DomainGPCR_Rhodpsn_7TM

OR8I2 OR10H5 GPR25 OR9Q2 GPR85 HCAR1 OR5T2 NMUR2 OR10H2 OR10H1 OR6C76 OR51I2 OR5H6

4.61e-0367015813IPR017452
Domain7tm_1

OR8I2 OR10H5 GPR25 OR9Q2 GPR85 HCAR1 OR5T2 NMUR2 OR10H2 OR10H1 OR6C76 OR51I2 OR5H6

5.02e-0367715813PF00001
DomainSSD

PTCHD3 DISP2

5.22e-03131582IPR000731
DomainELM2_dom

MTA2 MTA1

5.22e-03131582IPR000949
DomainSSD

PTCHD3 DISP2

5.22e-03131582PS50156
DomainOLF

ADGRL1 OLFML3

5.22e-03131582PF02191
DomainPeptidase_M1_N

LNPEP TAF2

5.22e-03131582IPR014782
DomainELM2

MTA2 MTA1

5.22e-03131582PF01448
DomainPeptidase_M1

LNPEP TAF2

5.22e-03131582PF01433
DomainOLF

ADGRL1 OLFML3

5.22e-03131582PS51132
DomainELM2

MTA2 MTA1

5.22e-03131582PS51156
DomainELM2

MTA2 MTA1

5.22e-03131582SM01189
DomainOlfac-like_dom

ADGRL1 OLFML3

5.22e-03131582IPR003112
DomainOLF

ADGRL1 OLFML3

5.22e-03131582SM00284
DomainG_PROTEIN_RECEP_F1_1

OR8I2 OR10H5 GPR25 OR9Q2 GPR85 HCAR1 OR5T2 NMUR2 OR10H2 OR10H1 OR6C76 OR51I2 OR5H6

5.53e-0368515813PS00237
DomainG_PROTEIN_RECEP_F1_2

OR8I2 OR10H5 GPR25 OR9Q2 GPR85 HCAR1 OR5T2 NMUR2 OR10H2 OR10H1 OR6C76 OR51I2 OR5H6

5.93e-0369115813PS50262
DomainGPCR_Rhodpsn

OR8I2 OR10H5 GPR25 OR9Q2 GPR85 HCAR1 OR5T2 NMUR2 OR10H2 OR10H1 OR6C76 OR51I2 OR5H6

6.00e-0369215813IPR000276
DomainRasGAP

RASA2 NF1

6.05e-03141582SM00323
DomainZP_2

ZP1 GP2

6.05e-03141582PS51034
DomainZP_1

ZP1 GP2

6.05e-03141582PS00682
DomainRasGAP_CS

RASA2 NF1

6.05e-03141582IPR023152
DomainOlfact_rcpt

OR8I2 OR10H5 OR9Q2 OR5T2 OR10H2 OR10H1 OR6C76 OR51I2 OR5H6

6.35e-033931589IPR000725
DomainRasGAP

RASA2 NF1

6.95e-03151582PF00616
DomainRAS_GTPASE_ACTIV_1

RASA2 NF1

6.95e-03151582PS00509
DomainZnf_GATA

MTA2 MTA1

6.95e-03151582IPR000679
DomainGATA

MTA2 MTA1

6.95e-03151582PF00320
DomainRAS_GTPASE_ACTIV_2

RASA2 NF1

6.95e-03151582PS50018
DomainZP

ZP1 GP2

6.95e-03151582SM00241
DomainPOU

POU1F1 POU3F3

7.89e-03161582SM00352
DomainGATA_ZN_FINGER_1

MTA2 MTA1

7.89e-03161582PS00344
DomainPOU_dom

POU1F1 POU3F3

7.89e-03161582IPR000327
DomainPou

POU1F1 POU3F3

7.89e-03161582PF00157
DomainGATA_ZN_FINGER_2

MTA2 MTA1

7.89e-03161582PS50114
DomainPOU_1

POU1F1 POU3F3

7.89e-03161582PS00035
DomainPOU_2

POU1F1 POU3F3

7.89e-03161582PS00465
DomainPOU_3

POU1F1 POU3F3

7.89e-03161582PS51179
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1A CACNA1B CACNA1D CACNA1H

3.53e-05231174M47666
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1A CACNA1B CACNA1D CACNA1H

4.98e-05251174M47948
Pubmed

The bHLH transcription factor Hand2 regulates the expression of nanog in ANS differentiation.

NANOGP8 NANOG HAND2

3.74e-074159319785992
Pubmed

The pluripotency regulator Zic3 is a direct activator of the Nanog promoter in ESCs.

NANOGP8 NANOG ZIC3

3.74e-074159320872845
Pubmed

Interactions of Rabconnectin-3 with Cav2 calcium channels.

CACNA1A CACNA1B WDR7

3.74e-074159331253182
Pubmed

Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.

CACNA1A CACNA1B CACNA1D

9.31e-075159311296258
Pubmed

Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.

CACNA1A CACNA1B CACNA1D

9.31e-075159315451373
Pubmed

DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development.

NANOGP8 NANOG DDB1 DCAF10

2.37e-0621159430111536
Pubmed

Zic3 is required for maintenance of pluripotency in embryonic stem cells.

NANOGP8 NANOG ZIC3

3.24e-067159317267691
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

VWA5B2 MTA2 OBSCN CHSY1 ADGRL1 NPHP4 TIAM2 TBC1D24 SLC52A3 SYNE3 SARS2 MAP1S NBEAL2 COBL DISP2 CACNA1H DEPDC5 PREX1

3.39e-0611051591835748872
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CACNA1A CACNA1B CACNA1D SCN7A KCNJ16 SCNN1B CACNA1H

3.76e-06139159716985003
Pubmed

The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo.

TAF1A TAF9B TAF2 TAF9 HAND2

4.10e-0652159528893950
Pubmed

Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells.

MTA2 NANOGP8 NANOG MTA1

4.16e-0624159418454139
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

CACNA1A CACNA1B DLGAP1 WDR7 CAMSAP3 MYO18A ADGRL1 ARHGAP39 NF1 MACF1

4.92e-063471591017114649
Pubmed

Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.

CACNA1B CACNA1D CACNA1H

5.16e-068159328330839
Pubmed

Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells.

NANOGP8 NANOG POU3F3 ZIC3

5.81e-0626159422992956
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SMG1 NCAPD3 CHSY1 CACHD1 TIAM2 TBC1D24 STAB1 USP38 AMIGO3 NBEAL2 DEPDC5 HPS5

6.39e-065291591214621295
Pubmed

Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.

ARHGAP39 MACF1 CACNA1H ZNF598

6.80e-0627159419026994
Pubmed

Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs.

MTA2 NANOGP8 NANOG

7.72e-069159318983969
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1A CACNA1B CACNA1H

7.72e-069159316382099
Pubmed

Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst.

NANOGP8 NANOG CUBN

1.51e-0511159318083160
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RIPOR2 WDR7 ADGRL1 URB2 CSMD3 PACS2 COBL MACF1 DISP2 CACNA1H

1.96e-054071591012693553
Pubmed

Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels.

CACNA1A CACNA1B

2.08e-052159223426690
Pubmed

Functional evidence that the self-renewal gene NANOG regulates human tumor development.

NANOGP8 NANOG

2.08e-052159219415763
Pubmed

Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers.

CACNA1A CACNA1B

2.08e-052159223376566
Pubmed

In vivo functional analysis of the histone 3-like TAF9 and a TAF9-related factor, TAF9L.

TAF9B TAF9

2.08e-052159212837753
Pubmed

CaV 2.1 α1  subunit motifs that control presynaptic CaV 2.1 subtype abundance are distinct from CaV 2.1 preference.

CACNA1A CACNA1B

2.08e-052159238155373
Pubmed

Exome sequencing and network analysis identifies shared mechanisms underlying spinocerebellar ataxia.

TGM6 FAT2

2.08e-052159229053796
Pubmed

The CAMSAP3-ACF7 Complex Couples Noncentrosomal Microtubules with Actin Filaments to Coordinate Their Dynamics.

CAMSAP3 MACF1

2.08e-052159227693509
Pubmed

N-type calcium current, Cav2.2, is enhanced in small-diameter sensory neurons isolated from Nf1+/- mice.

CACNA1B NF1

2.08e-052159224755485
Pubmed

Overexpression of MTA1 inhibits the metastatic ability of ZR-75-30 cells in vitro by promoting MTA2 degradation.

MTA2 MTA1

2.08e-052159230642362
Pubmed

Assignment of the metastasis-associated gene (Mta1) to mouse chromosome band 12F and the metastasis-associated gene 2 (Mta2) to mouse chromosome band 19B by fluorescence in situ hybridization.

MTA2 MTA1

2.08e-052159211856890
Pubmed

Nanog1 in NTERA-2 and recombinant NanogP8 from somatic cancer cells adopt multiple protein conformations and migrate at multiple M.W species.

NANOGP8 NANOG

2.08e-052159224598770
Pubmed

Control of apico-basal epithelial polarity by the microtubule minus-end-binding protein CAMSAP3 and spectraplakin ACF7.

CAMSAP3 MACF1

2.08e-052159227802168
Pubmed

Differential expression of nanog1 and nanogp8 in colon cancer cells.

NANOGP8 NANOG

2.08e-052159222079639
Pubmed

Age-related and tissue-specific accumulation of oxidative DNA base damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient mice.

OGG1 MTA1

2.08e-052159211532868
Pubmed

Expression analysis of P/Q-type Ca2+ channel alpha 1A subunit mRNA in olfactory mitral cell in N-type Ca2+ channel alpha 1B subunit gene-deficient mice.

CACNA1A CACNA1B

2.08e-052159215050706
Pubmed

Nuclear factor 1 synergizes with progesterone receptor on the mouse mammary tumor virus promoter wrapped around a histone H3/H4 tetramer by facilitating access to the central hormone-responsive elements.

PGR NF1

2.08e-052159219940123
Pubmed

Expression of NANOG and NANOGP8 in a variety of undifferentiated and differentiated human cells.

NANOGP8 NANOG

2.08e-052159221136380
Pubmed

The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2.

PGR HAND2

2.08e-052159221330545
Pubmed

RANBP17 Overexpression Restores Nucleocytoplasmic Transport and Ameliorates Neurodevelopment in Induced DYT1 Dystonia Motor Neurons.

TOR1A RANBP17

2.08e-052159238438257
Pubmed

Defining the membrane proteome of NK cells.

MTA2 MYO1G NCAPD3 PNKP ZMPSTE24 PEX3 MYO18A CHSY1 OAS2 ANKZF1 SYNE3 NF1 LNPEP NBEAL2 GYS1 DLST GNAS

2.73e-0511681591719946888
Pubmed

Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

ZMPSTE24 TOR1A CHSY1 ADGRG1 CUBN NUDT9 OLFML3 SLC52A3 CACNA1H GALNT6

3.12e-054301591016303743
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

MTA2 NCAPD3 FAM234A ZMPSTE24 SGSH TOR1A CHSY1 ADGRG1 CACHD1 MINPP1 DDB1 ATF6B NF1 LNPEP SVIL DNASE1L1 MSLN

3.86e-0512011591735696571
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

SMG1 NCAPD3 ABCA4 RASA2 URB2 PIAS1 DNAH12 NF1 GYS1 DLST TAF2 PREX1

4.04e-056381591231182584
Pubmed

Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

CACNA1A CACNA1B CACNA1D

4.10e-0515159320188150
Pubmed

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

CACNA1A CACNA1B CACNA1D

4.10e-0515159324453333
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

DLGAP1 WDR7 CAMSAP3 CHSY1 ARHGAP39 NF1 MACF1 GNAS

4.86e-05281159828706196
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

ABCA4 SPOPL ARID4A NADK2 PEX3 CAMSAP3 C10orf90 TGM6 SLC52A3 ZP1 MTA1 NF1 SUPV3L1 NBEAL2 ARHGEF1 ZNF287 ALG13

5.84e-0512421591730973865
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

MTA2 NANOGP8 NANOG ZIC3 MTA1 TAF9

5.94e-05146159623892456
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

NCAPD3 ARID4A CAMSAP3 MYO18A ARHGAP39 TSSC4 MTA1 NF1 MAP1S SVIL KIAA1958 PLA2G4A PACS2

6.10e-057741591315302935
Pubmed

The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1.

NANOGP8 NANOG

6.21e-053159230814124
Pubmed

Multiple phases in regulation of Nanog expression during pre-implantation development.

NANOGP8 NANOG

6.21e-053159226660234
Pubmed

Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog.

NANOGP8 NANOG

6.21e-053159218177668
Pubmed

Differential effect of T-type voltage-gated Ca2+ channel disruption on renal plasma flow and glomerular filtration rate in vivo.

CACNA1D CACNA1H

6.21e-053159224966091
Pubmed

Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast.

NANOGP8 NANOG

6.21e-053159224929238
Pubmed

Munc13-3 Is Required for the Developmental Localization of Ca2+ Channels to Active Zones and the Nanopositioning of Cav2.1 Near Release Sensors.

CACNA1A CACNA1B

6.21e-053159229466725
Pubmed

Nanog and transcriptional networks in embryonic stem cell pluripotency.

NANOGP8 NANOG

6.21e-053159217211451
Pubmed

The stem cell pluripotency factor NANOG activates transcription with two unusually potent subdomains at its C terminus.

NANOGP8 NANOG

6.21e-053159215502159
Pubmed

Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis.

NANOGP8 NANOG

6.21e-053159220574542
Pubmed

lincRNAs act in the circuitry controlling pluripotency and differentiation.

NANOGP8 NANOG

6.21e-053159221874018
Pubmed

Cell signalling regulates dynamics of Nanog distribution in embryonic stem cell populations.

NANOGP8 NANOG

6.21e-053159223054952
Pubmed

Association study between polymorphisms in the CACNA1A, CACNA1C, and CACNA1H genes and drug-resistant epilepsy in the Chinese Han population.

CACNA1A CACNA1H

6.21e-053159226216687
Pubmed

CrxOS maintains the self-renewal capacity of murine embryonic stem cells.

NANOGP8 NANOG

6.21e-053159219800316
Pubmed

Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog.

NANOGP8 NANOG

6.21e-053159226975336
Pubmed

Nanog suppresses cell migration by downregulating thymosin β4 and Rnd3.

NANOGP8 NANOG

6.21e-053159223329853
Pubmed

Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming.

NANOGP8 NANOG

6.21e-053159223665121
Pubmed

Ectopic overexpression of Nanog induces tumorigenesis in non-tumorous fibroblasts.

NANOGP8 NANOG

6.21e-053159226733157
Pubmed

Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features.

NANOGP8 NANOG

6.21e-053159216501172
Pubmed

Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells.

NANOGP8 NANOG

6.21e-053159219582141
Pubmed

Nanog is the gateway to the pluripotent ground state.

NANOGP8 NANOG

6.21e-053159219703398
Pubmed

Nanog Fluctuations in Embryonic Stem Cells Highlight the Problem of Measurement in Cell Biology.

NANOGP8 NANOG

6.21e-053159228636920
Pubmed

The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms.

OAS2 OAS3

6.21e-05315929790745
Pubmed

A distinct expression pattern in mammalian testes indicates a conserved role for NANOG in spermatogenesis.

NANOGP8 NANOG

6.21e-053159220539761
Pubmed

Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes.

NANOGP8 NANOG

6.21e-053159218584034
Pubmed

Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells.

NANOGP8 NANOG

6.21e-053159221969378
Pubmed

The phosphoinositide-3-kinase/Akt pathway mediates the transient increase in Nanog expression during differentiation of F9 cells.

NANOGP8 NANOG

6.21e-053159220661723
Pubmed

NANOG restores the impaired myogenic differentiation potential of skeletal myoblasts after multiple population doublings.

NANOGP8 NANOG

6.21e-053159229245050
Pubmed

Aggregation of embryonic stem cells induces Nanog repression and primitive endoderm differentiation.

NANOGP8 NANOG

6.21e-053159215494369
Pubmed

Identification of two distinct transactivation domains in the pluripotency sustaining factor nanog.

NANOGP8 NANOG

6.21e-053159214728807
Pubmed

The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.

CACNA1A CACNA1B

6.21e-053159238996073
Pubmed

Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions.

NANOGP8 NANOG

6.21e-053159221194951
Pubmed

Identification and regulation of a stage-specific stem cell niche enriched by Nanog-positive spermatogonial stem cells in the mouse testis.

NANOGP8 NANOG

6.21e-053159222388986
Pubmed

Nanog promotes transfer of pluripotency after cell fusion.

NANOGP8 NANOG

6.21e-053159216791199
Pubmed

Heparan sulfate regulates self-renewal and pluripotency of embryonic stem cells.

NANOGP8 NANOG

6.21e-053159218024963
Pubmed

The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cells.

NANOGP8 NANOG

6.21e-053159227125671
Pubmed

Identification and characterization of metastasis-associated gene/protein 1 (MTA1).

MTA2 MTA1

6.21e-053159225315816
Pubmed

Stochastic promoter activation affects Nanog expression variability in mouse embryonic stem cells.

NANOGP8 NANOG

6.21e-053159225410303
Pubmed

Genome editing demonstrates that the -5 kb Nanog enhancer regulates Nanog expression by modulating RNAPII initiation and/or recruitment.

NANOGP8 NANOG

6.21e-053159233334884
Pubmed

Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19.

OAS2 OAS3

6.21e-053159233138195
Pubmed

Forced expression of Nanog in hematopoietic stem cells results in a gammadeltaT-cell disorder.

NANOGP8 NANOG

6.21e-053159217360937
Pubmed

Nanog dynamics in single embryonic stem cells.

NANOGP8 NANOG

6.21e-053159226760119
Pubmed

GPR56 C-terminal fragment mediates signal received by N-terminal fragment of another adhesion GPCR Latrophilin1 in neurons.

ADGRG1 ADGRL1

6.21e-053159236453010
Pubmed

Nanog is dispensable for the generation of induced pluripotent stem cells.

NANOGP8 NANOG

6.21e-053159224461999
Pubmed

Locating and Characterizing a Transgene Integration Site by Nanopore Sequencing.

NANOGP8 NANOG

6.21e-053159230837263
Pubmed

Structure, expression and functions of MTA genes.

MTA2 MTA1

6.21e-053159226869315
Pubmed

Nanog induces hyperplasia without initiating tumors.

NANOGP8 NANOG

6.21e-053159225173648
Pubmed

Distinct Contributions of Tryptophan Residues within the Dimerization Domain to Nanog Function.

NANOGP8 NANOG

6.21e-053159227939294
Pubmed

Molecular moieties masking Ca2+-dependent facilitation of voltage-gated Cav2.2 Ca2+ channels.

CACNA1A CACNA1B

6.21e-053159229208674
Pubmed

Identification of genes regulated by nanog which is involved in ES cells pluripotency and early differentiation.

NANOGP8 NANOG

6.21e-053159218442017
Pubmed

Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development.

PGR HAND2

6.21e-053159224265601
Pubmed

Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.

CACNA1A CACNA1B

6.21e-053159226507659
Cytoband3p14.3

CACNA1D SPATA12 DNAH12

1.55e-043015933p14.3
CytobandEnsembl 112 genes in cytogenetic band chr11q12

MTA2 OR8I2 OR9Q2 OR5T2 DDB1 ZP1 MS4A13

2.14e-043451597chr11q12
GeneFamilyCalcium voltage-gated channel subunits

CACNA1A CACNA1B CACNA1D CACNA1H

1.46e-05261054253
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

OBSCN TIAM2 ARHGEF1 PREX1

5.87e-04661054722
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYO1G RIPOR2 RASA2 ADGRG1 LNPEP ARHGEF1 MACF1

5.57e-061901597d153a0bdedcd6865e6ee19575234a78b5d859ff1
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Rbp4-Inhibitory_Neuron.Gad1Gad2_Sst.Rbp4_(Interneuron,_OLM2_(CA1_enriched?))|Hippocampus / BrainAtlas - Mouse McCarroll V32

IRS4 TGM6 MBOAT4 CORIN BTNL9

8.33e-067715959a29879348b32b6c2302820f75fd55efba39aae8
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Rbp4-Inhibitory_Neuron.Gad1Gad2_Sst.Rbp4_(Interneuron,_OLM2_(CA1_enriched?))-|Hippocampus / BrainAtlas - Mouse McCarroll V32

IRS4 TGM6 MBOAT4 CORIN BTNL9

8.33e-06771595c5262a0d2040b2c580601e5a8d1ec626a0c7b560
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Rbp4|Hippocampus / BrainAtlas - Mouse McCarroll V32

IRS4 TGM6 MBOAT4 CORIN BTNL9

8.33e-067715953763b55e5ce44b844da661e9024c9f2c847ea26f
Diseasefamilial hemiplegic migraine 1 (implicated_via_orthology)

CACNA1A CACNA1B

7.99e-0531532DOID:0111181 (implicated_via_orthology)
Diseasemigraine (implicated_via_orthology)

CACNA1A CACNA1B

1.59e-0441532DOID:6364 (implicated_via_orthology)
DiseaseAkinetic Petit Mal

CACNA1A CACNA1H

5.51e-0471532C0001890
DiseaseEpilepsy, Absence, Atypical

CACNA1A CACNA1H

5.51e-0471532C0751124
DiseaseAbsence Seizure Disorder

CACNA1A CACNA1H

5.51e-0471532C4553705
DiseaseJuvenile Absence Epilepsy

CACNA1A CACNA1H

5.51e-0471532C4317339
DiseaseChildhood Absence Epilepsy

CACNA1A CACNA1H

5.51e-0471532C4281785
DiseaseEpilepsy, Minor

CACNA1A CACNA1H

5.51e-0471532C4552765
DiseaseHereditary clear cell renal cell carcinoma

HSPBAP1 OGG1

5.51e-0471532C1333985
DiseaseAbsence Epilepsy

CACNA1A CACNA1H

5.51e-0471532C0014553
Diseasehereditary ataxia (implicated_via_orthology)

CACNA1A CACNA1B

5.51e-0471532DOID:0050951 (implicated_via_orthology)
DiseaseIntellectual Disability

CACNA1B POU3F3 NF1 PACS2 MACF1 TAF2 GNAS ZNF292 ALG13

5.66e-044471539C3714756
DiseaseUnilateral agenesis of kidney

GREB1L DSTYK

7.33e-0481532C0266294
DiseaseSeizures

CACNA1B PNKP SGSH PACS2 MACF1 ZNF292

9.95e-042181536C0036572
DiseasePseudohypoaldosteronism, Type I

SCNN1B GNAS

1.17e-03101532C0268436
Diseasemyelodysplastic syndrome

PLA2G4A TAF2

1.17e-03101532EFO_0000198
DiseasePseudohypoaldosteronism

SCNN1B GNAS

1.17e-03101532C0033805
DiseaseHyperpotassemia and Hypertension, Familial

SCNN1B GNAS

1.17e-03101532C2713447
DiseasePseudohypoaldosteronism, Type I, Autosomal Recessive

SCNN1B GNAS

1.17e-03101532C1449843
DiseasePseudohypoaldosteronism, Type II

SCNN1B GNAS

1.17e-03101532C1449844
DiseasePseudohypoaldosteronism, Type I, Autosomal Dominant

SCNN1B GNAS

1.17e-03101532C1449842
Diseasecolorectal cancer

DLGAP1 PTCHD3 CUBN CCL26 PIAS1 DSTYK MACF1 GNAS PREX1 SMC1B

1.26e-0360415310MONDO_0005575
Diseasecolon cancer (implicated_via_orthology)

NANOGP8 NANOG

1.42e-03111532DOID:219 (implicated_via_orthology)
Diseasesciatic neuropathy (biomarker_via_orthology)

CACNA1D NF1 AMIGO3 CACNA1H

1.79e-03991534DOID:11446 (biomarker_via_orthology)
DiseaseAutistic Disorder

CSMD3 NF1 SCN7A PLA2G4A CACNA1H ZNF292

2.47e-032611536C0004352
Diseasecomplement C4 measurement

DXO MUC21 ATF6B

2.51e-03521533EFO_0004984
Diseasetreatment-resistant hypertension

CACNA1D DLGAP1 ENPP3 TAF1A

2.54e-031091534EFO_1002006
DiseaseColorectal Carcinoma

IRS4 ABCA4 OBSCN CUBN CSMD3 NF1 ARHGEF1 SCNN1B GNAS ZNF292

3.73e-0370215310C0009402
Diseasepolycystic kidney disease (biomarker_via_orthology)

PLA2G4A GNAS

4.31e-03191532DOID:0080322 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
RVAEFSLSGSQRNIC

URB2

106

Q14146
CLTVNRSLFLFSEDN

CACNA1A

71

O00555
QSRLSRCRAAAFFLS

FAM234A

41

Q9H0X4
RFSEQTCALSLERFS

BTNL9

366

Q6UXG8
ISSRFCSRQSFALEQ

ARHGEF1

511

Q92888
SCLFRAISEQLFCSQ

ALG13

241

Q9NP73
FEEYCRSANIQFRTV

ARID4A

396

P29374
FAIQFSSSVATACRD

CSMD3

1516

Q7Z407
SYDRRTTSFCNALIQ

ABCA4

361

P78363
TFCFLRGLQTDRNTI

ADGRL1

881

O94910
RDDSSVFRCRAQAAN

GPR25

341

O00155
VFRCRAQAANTASAS

GPR25

346

O00155
NFNTNVSRTISCDRL

CACHD1

141

Q5VU97
SCDRLSTTVNSRAFN

CACHD1

151

Q5VU97
CFRRFTRSNSVTTAV

DLGAP1

686

O14490
VRFFQHSRVFENCSS

AMIGO3

261

Q86WK7
QNCFTVNRSLFVFSE

CACNA1B

66

Q00975
NHFLILFRDSSCQFR

CAMSAP3

1156

Q9P1Y5
CHRARNQSFFDTLQE

DISP2

816

A7MBM2
SFRSTFRQQSSLGLC

CCDC27

26

Q2M243
SCLVQFASTRRSLFN

RANBP17

281

Q9H2T7
GTFARALDCSSSIRQ

MTA2

201

O94776
DANTIFRGNSLATRC

RASA2

391

Q15283
DLAACAQFESSRQSR

ARHGAP39

656

Q9C0H5
SRARIQCSFDASGTL

OLFML3

341

Q9NRN5
QSNRRSISFVGCFVQ

OR8I2

86

Q8N0Y5
FRETRAAQDFFSTCR

UROD

46

P06132
FTDFCINRDNRLVTF

DEPDC5

1576

O75140
TISQARCAAQFFLFT

OR9Q2

91

Q8NGE9
LSTQRSIAFLACASQ

OR10H5

86

Q8NGA6
LSTQRSIAFLACASQ

OR10H2

86

O60403
VVFFNACEAASRLAR

MAP1S

336

Q66K74
SRRFQAAFQNVISSF

NMUR2

331

Q9GZQ4
CVRNSLSLRNTFNTA

MUC21

501

Q5SSG8
IANRVFSSSRQRCFS

NADK2

381

Q4G0N4
CVSAIRELFNFSSCQ

ENTPD8

316

Q5MY95
CQVATAFNLSRFSSA

ASMTL

441

O95671
TCCLFQNSVIASRAR

HPS5

376

Q9UPZ3
NFCFLRIRTKSSNTA

FAT2

91

Q9NYQ8
VLRTFCLNARNITFD

OR51I2

81

Q9H344
SSRCRGIQAFRNSFS

NUDT9

26

Q9BW91
EQTSRNLTLFQAACR

MYO18A

1186

Q92614
FSTVLNTCLNRGFSR

PEX3

276

P56589
NIRFLDNRLFATCSD

DCAF10

216

Q5QP82
FIIRNSCSNQRDSTI

GP2

416

P55259
FRSIVQCVNDFRSVS

DDHD2

231

O94830
RCIRHFNICSINSFS

DNAH12

2021

Q6ZR08
VFSSTQLCVLNDRFQ

NANOG

101

Q9H9S0
SGFSVRENCSTRQLV

LMLN2

326

A0A1B0GTW7
FFENQSEATFRLRCV

LNPEP

986

Q9UIQ6
ACTRFFSRITKANVD

MSLN

136

Q13421
SRNTQAFFRVFGSCS

KCNRG

116

Q8N5I3
FVCRFCNRRFSQSST

PRDM12

271

Q9H4Q4
LFSFICSSNNNIARI

OGG1

141

O15527
AAFSTIVSRIQRYCN

PACS2

526

Q86VP3
STCFTVLQRNFIRSR

OAS2

521

P29728
RTNSSGLLICRFNNF

GREB1L

1721

Q9C091
LRNFSLEISFTSVCN

OR6C76

61

A6NM76
CSQFRTRLNSSHEAF

DSTYK

586

Q6XUX3
NTNVAFCSVLRSRLG

DXO

211

O77932
FRATQNVFTRQLCLE

MACF1

3356

Q9UPN3
QFLAFSRVAQDCRGT

NPHP4

646

O75161
EAFSFRLTFCNSNII

OR5H6

176

Q8NGV6
RTQSINSAFAELREC

HAND2

111

P61296
DASFQCRLSRASGQE

OBSCN

4266

Q5VST9
RCVSRAFSRSLSAFQ

DLST

6

P36957
CLNTFIQSRALSVEF

PGR

891

P06401
FNTFALEAASTRQRC

CUBN

3201

O60494
NAAVSAFFDRCRTSE

HSPBAP1

326

Q96EW2
AQAFRICAFNAQRLT

DNASE1L1

16

P49184
FSFCSTRCLQDHRRQ

ANKZF1

706

Q9H8Y5
FSFNSEEIVRNLSCR

ENPP3

416

O14638
SQVLQFFSSDICRSI

CD36

261

P16671
CFNAFASDRISLQRS

GALNT6

141

Q8NCL4
HRSSCFSLVQSSQRD

COBL

971

O75128
DFRFCSQRNQTHRSS

ADGRG1

31

Q9Y653
DFLRCSQFRNQTESS

CORIN

236

Q9Y5Q5
CSFQRFQARVQGSSA

MBOAT4

181

Q96T53
ESDFSRSFNCSARNR

KIRREL2

476

Q6UWL6
QCTFQHRSFRANDSL

GPR85

171

P60893
SNLGRRSCISVANSF

HCAR1

316

Q9BXC0
NTLRNFTRASEAVAC

DCST2

111

Q5T1A1
RFRSLDDSCSQLTSF

GYS1

556

P13807
QLTSFLYSFCQQSRR

GYS1

566

P13807
HTQDTNTFFLCRTLR

FLAD1

126

Q8NFF5
CLTVLSRRFEFQADA

ZMPSTE24

406

O75844
TAFRISVTSSCFVQN

BAGE2

71

Q86Y30
LRNRCFLDSAFVRNN

CACNA1H

256

O95180
CSLNRTQCTFRNFTS

SCNN1B

196

P51168
SQTTICRFEALQLSF

POU3F3

356

P20264
SSFNFECLRRQSSQE

CACNA1D

1921

Q01668
FRSLSTTNVFACSDR

DDB1

641

Q16531
CRSEFNDAIVISNRA

NEURL4

741

Q96JN8
LFAVTSCFRFDCIRN

PTCHD3

396

Q3KNS1
CSNLFRRQNDLTSVT

MS4A13

131

Q5J8X5
LSTQRSIAFLACASQ

OR10H1

86

Q9Y4A9
AACFTELRRNFVNIR

OAS3

181

Q9Y6K5
CSVSLSNVEARRFFN

PLA2G4A

726

P47712
QSRSQSFFAAARAAV

IRS4

1086

O14654
SASNCTDFQSRRLHI

SARS2

421

Q9NP81
VRLAIQCRADQSFTS

TAF9B

71

Q9HBM6
VRLAIQCRADQSFTS

TAF9

71

Q16594
ENQDTSSRRFTAFPC

TRIM38

321

O00635
VNVLRLFSSADFCNL

SLC52A3

451

Q9NQ40
RTAQACTALAFNLRR

TBC1D31

81

Q96DN5
DTRRFFCSVEQNALS

SPATA21

286

Q7Z572
QLRSAFLASANACRR

SVIL

596

O95425
RSCTLANNFARSFTL

SYNE3

951

Q6ZMZ3
CRFLLNSRVTDAAFN

TMEM120A

151

Q9BXJ8
CDRIIFTGLFANRSS

NXPE2

211

Q96DL1
SQTTICRFENLQLSF

POU1F1

166

P28069
RRKDFAQTTSACLSF

TAF1A

46

Q15573
LTRRCLAQSLAQQFF

TAF2

341

Q6P1X5
VFSSTQLCVLNDRFQ

NANOGP8

101

Q6NSW7
IVSDRFSLFLNCTNC

PKDREJ

471

Q9NTG1
FTCAVDTENIRRVFN

GNAS

1006

Q5JWF2
VQLQSGRFDCSDRQF

NBEAL2

2181

Q6ZNJ1
VIRTFFYTNRQTCQD

SMG1

1011

Q96Q15
FSEVESILNQSFCSR

PREX1

681

Q8TCU6
RCFLFTATLEQARHN

PNKP

446

Q96T60
VCSSLLQFARQYSRN

SUPV3L1

586

Q8IYB8
GTFARALDCSSSVRQ

MTA1

221

Q13330
LASDNSQRFRETCFA

PIAS1

156

O75925
ATFSLSFCGANEIRR

OR5T2

201

Q8NGG2
RSLLFRNAFTSVSSC

SGSH

56

P51688
RRSRCNSFIENSSAL

RIPOR2

31

Q9Y4F9
EFTSNSCSQRAVIFT

CCL26

51

Q9Y258
FLSSDCRHFNRTESL

ATF6B

496

Q99941
TFNCVERQVGRQSAF

CILP

1116

O75339
FTTEFLQRCRANTVL

CHSY1

636

Q86X52
NICFSARDLSQIRNA

NCAPD3

201

P42695
RSFACTEFSRNSSVV

C10orf90

191

Q96M02
RRLIDQSFLAFESSC

TBC1D24

166

Q9ULP9
AFNSTREFLFRQRSS

ZIC3

111

O60481
FLRDTETCRQNFRNF

ZNF287

41

Q9HBT7
RGNVSACARSIFIFD

TOR1A

156

O14656
RDSTFQLHVRCVFNA

ZP1

366

P60852
NTFVRLADTHFVQRC

POLR3C

146

Q9BUI4
RSAEQITALCRSFND

TIAM2

1056

Q8IVF5
INSRSSCTLFQDIFQ

MINPP1

331

Q9UNW1
SRSNQLTFTEGCFVR

SPATA12

161

Q7Z6I5
GCSEFRFNDNLVSRS

SMC1B

101

Q8NDV3
NTRFTDCSFFVRGQE

SPOPL

196

Q6IQ16
QCLVQLSSARSTFRF

UBE3D

256

Q7Z6J8
RRSFSAVAIVSSCEN

KCNJ16

371

Q9NPI9
EFRCQVSDCSRIFQA

ZNF292

2171

O60281
SSTFSQRSRDIFDCL

TSSC4

86

Q9Y5U2
SCNNFNAVFSRISTR

NF1

146

P21359
TRRFRCTQGFQLQDT

STAB1

1276

Q9NY15
RARALQAASASCSFR

USP38

996

Q8NB14
RCSTEQFTHAFRTEI

ZNF598

246

Q86UK7
RRFNESAAERHTNFC

ZC2HC1B

126

Q5TFG8
DFVNAIRSARSAFCL

ZSWIM8

1786

A7E2V4
VSFQLQSRRRSQAAC

VWA5B2

71

Q8N398
NRTIFRFNAASILCT

SCN7A

86

Q01118
RSVDALQTAFADARC

PLIN5

321

Q00G26
QCFREFRTQSIFTRH

ZNF557

261

Q8N988
NCQSISFCAFTQRSL

WDR7

216

Q9Y4E6
TQRAFRCETCGASFV

ZFP64

576

Q9NTW7
RCLGIATRVVSNFNS

TGM6

286

O95932
CEFCARSFRTSSNLV

ZNF692

391

Q9BU19
RVCFQDNRSFNSDSP

KIAA1958

71

Q8N8K9
STCVLEAFGNARTNR

MYO1G

141

B0I1T2