Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium-dependent protein serine/threonine kinase activity

MAPKAPK2 MAPKAPK3

3.44e-0510182GO:0009931
GeneOntologyMolecularFunctioncalcium/calmodulin-dependent protein kinase activity

MAPKAPK2 MAPKAPK3

2.66e-0427182GO:0004683
GeneOntologyMolecularFunctionmitogen-activated protein kinase binding

MAPKAPK2 MAPKAPK3

4.49e-0435182GO:0051019
GeneOntologyMolecularFunctioncell adhesion molecule binding

NFASC GIGYF2 AGER NEO1

1.75e-03599184GO:0050839
GeneOntologyMolecularFunctioncell adhesion mediator activity

NFASC AGER

2.10e-0376182GO:0098631
GeneOntologyBiologicalProcessregulation of axon regeneration

PTPRS GRN NEO1

5.40e-0640183GO:0048679
GeneOntologyBiologicalProcessregulation of neuron projection regeneration

PTPRS GRN NEO1

8.83e-0647183GO:0070570
GeneOntologyBiologicalProcesspositive regulation of aspartic-type peptidase activity

GRN AGER

1.51e-057182GO:1905247
GeneOntologyBiologicalProcessregulation of aspartic-type peptidase activity

GRN AGER

2.58e-059182GO:1905245
GeneOntologyBiologicalProcessaxon regeneration

PTPRS GRN NEO1

2.82e-0569183GO:0031103
GeneOntologyBiologicalProcessmacropinocytosis

MAPKAPK2 MAPKAPK3

3.94e-0511182GO:0044351
GeneOntologyBiologicalProcessneuron projection regeneration

PTPRS GRN NEO1

4.56e-0581183GO:0031102
GeneOntologyBiologicalProcessregulation of dendritic spine development

PTPRS SDK1 GRN

6.46e-0591183GO:0060998
GeneOntologyBiologicalProcessregulation of innate immune response

GIGYF2 PTPRS MAPKAPK2 GRN MAPKAPK3

6.46e-05519185GO:0045088
GeneOntologyBiologicalProcessregulation of response to external stimulus

GIGYF2 PTPRS MAPKAPK2 GRN AGER NEO1 MAPKAPK3

7.22e-051316187GO:0032101
GeneOntologyBiologicalProcessnegative regulation of axon regeneration

PTPRS NEO1

9.71e-0517182GO:0048681
GeneOntologyBiologicalProcessresponse to axon injury

PTPRS GRN NEO1

9.89e-05105183GO:0048678
GeneOntologyBiologicalProcessregulation of defense response

GIGYF2 PTPRS MAPKAPK2 GRN AGER MAPKAPK3

1.48e-041006186GO:0031347
GeneOntologyBiologicalProcessnegative regulation of neuron projection regeneration

PTPRS NEO1

1.64e-0422182GO:0070571
GeneOntologyBiologicalProcessregulation of response to biotic stimulus

GIGYF2 PTPRS MAPKAPK2 GRN MAPKAPK3

1.77e-04643185GO:0002831
GeneOntologyBiologicalProcessretina layer formation

SDK1 SDK2

2.13e-0425182GO:0010842
GeneOntologyBiologicalProcesspinocytosis

MAPKAPK2 MAPKAPK3

2.13e-0425182GO:0006907
GeneOntologyBiologicalProcesscell-cell adhesion

NFASC PTPRS SDK1 AGER NEO1 SDK2

2.16e-041077186GO:0098609
GeneOntologyBiologicalProcessregulation of immune response

GIGYF2 PTPRS MAPKAPK2 GRN AGER MAPKAPK3

2.24e-041085186GO:0050776
GeneOntologyBiologicalProcessdendritic spine development

PTPRS SDK1 GRN

2.37e-04141183GO:0060996
GeneOntologyBiologicalProcesssynapse organization

NFASC PTPRS SDK1 GRN SDK2

2.38e-04685185GO:0050808
GeneOntologyBiologicalProcessmRNA catabolic process

MEIOC GIGYF2 MAPKAPK2 NCBP1

2.63e-04373184GO:0006402
GeneOntologyBiologicalProcessastrocyte activation

GRN AGER

2.88e-0429182GO:0048143
GeneOntologyBiologicalProcessmale meiosis I

MEIOC ZSCAN21

3.29e-0431182GO:0007141
GeneOntologyBiologicalProcesspositive regulation of response to external stimulus

PTPRS MAPKAPK2 GRN AGER MAPKAPK3

3.36e-04738185GO:0032103
GeneOntologyBiologicalProcessRNA catabolic process

MEIOC GIGYF2 MAPKAPK2 NCBP1

4.60e-04432184GO:0006401
GeneOntologyBiologicalProcessregulation of mRNA metabolic process

MEIOC GIGYF2 MAPKAPK2 NCBP1

5.06e-04443184GO:1903311
GeneOntologyBiologicalProcesspositive regulation of response to biotic stimulus

PTPRS MAPKAPK2 GRN MAPKAPK3

5.41e-04451184GO:0002833
GeneOntologyBiologicalProcessneuron projection development

NFASC PTPRS SDK1 GRN AGER NEO1

5.60e-041285186GO:0031175
GeneOntologyBiologicalProcessdefense response to symbiont

GIGYF2 PTPRS MAPKAPK2 NCBP1 GRN MAPKAPK3

5.62e-041286186GO:0140546
GeneOntologyBiologicalProcessnucleic acid catabolic process

MEIOC GIGYF2 MAPKAPK2 NCBP1

6.02e-04464184GO:0141188
GeneOntologyBiologicalProcessastrocyte development

GRN AGER

7.60e-0447182GO:0014002
GeneOntologyBiologicalProcessretina development in camera-type eye

SDK1 GRN SDK2

7.69e-04211183GO:0060041
GeneOntologyBiologicalProcessregulation of response to wounding

PTPRS GRN NEO1

8.34e-04217183GO:1903034
GeneOntologyBiologicalProcessnegative regulation of response to external stimulus

GIGYF2 PTPRS GRN NEO1

8.52e-04509184GO:0032102
GeneOntologyBiologicalProcessdefense response to other organism

GIGYF2 PTPRS MAPKAPK2 NCBP1 GRN MAPKAPK3

9.06e-041407186GO:0098542
GeneOntologyBiologicalProcessneuron development

NFASC PTPRS SDK1 GRN AGER NEO1

1.11e-031463186GO:0048666
GeneOntologyBiologicalProcesscell junction organization

NFASC PTPRS SDK1 GRN SDK2

1.19e-03974185GO:0034330
GeneOntologyBiologicalProcessanatomical structure formation involved in morphogenesis

ANPEP NFASC SDK1 GRN NEO1 SDK2

1.19e-031483186GO:0048646
GeneOntologyBiologicalProcessmicroglial cell activation

GRN AGER

1.19e-0359182GO:0001774
GeneOntologyBiologicalProcessmale meiotic nuclear division

MEIOC ZSCAN21

1.24e-0360182GO:0007140
GeneOntologyBiologicalProcessregeneration

PTPRS GRN NEO1

1.28e-03252183GO:0031099
GeneOntologyBiologicalProcesscell junction assembly

NFASC PTPRS SDK1 SDK2

1.29e-03569184GO:0034329
GeneOntologyBiologicalProcessleukocyte activation involved in inflammatory response

GRN AGER

1.36e-0363182GO:0002269
GeneOntologyBiologicalProcesspositive regulation of defense response

PTPRS MAPKAPK2 GRN MAPKAPK3

1.46e-03589184GO:0031349
GeneOntologyBiologicalProcessp38MAPK cascade

MAPKAPK2 AGER

1.54e-0367182GO:0038066
GeneOntologyBiologicalProcessregulation of cellular response to stress

PTPRS MAPKAPK2 GRN NEO1

1.55e-03598184GO:0080135
GeneOntologyBiologicalProcessvascular endothelial growth factor receptor signaling pathway

MAPKAPK2 MAPKAPK3

1.63e-0369182GO:0048010
GeneOntologyBiologicalProcessglial cell activation

GRN AGER

1.68e-0370182GO:0061900
GeneOntologyBiologicalProcessregulation of mRNA stability

MEIOC GIGYF2 MAPKAPK2

1.96e-03292183GO:0043488
GeneOntologyBiologicalProcessinnate immune response

GIGYF2 PTPRS MAPKAPK2 GRN MAPKAPK3

1.98e-031092185GO:0045087
GeneOntologyBiologicalProcesspattern recognition receptor signaling pathway

PTPRS MAPKAPK2 MAPKAPK3

2.00e-03294183GO:0002221
GeneOntologyBiologicalProcessaxon development

NFASC PTPRS GRN NEO1

2.01e-03642184GO:0061564
GeneOntologyBiologicalProcessmRNA stabilization

MEIOC MAPKAPK2

2.02e-0377182GO:0048255
GeneOntologyBiologicalProcessresponse to wounding

PTPRS GRN AGER NEO1

2.21e-03659184GO:0009611
GeneOntologyBiologicalProcesssynapse assembly

PTPRS SDK1 SDK2

2.28e-03308183GO:0007416
GeneOntologyBiologicalProcessregulation of RNA stability

MEIOC GIGYF2 MAPKAPK2

2.28e-03308183GO:0043487
GeneOntologyBiologicalProcessregulation of mRNA catabolic process

MEIOC GIGYF2 MAPKAPK2

2.30e-03309183GO:0061013
GeneOntologyBiologicalProcessinnate immune response-activating signaling pathway

PTPRS MAPKAPK2 MAPKAPK3

2.36e-03312183GO:0002758
GeneOntologyBiologicalProcesscell-cell adhesion via plasma-membrane adhesion molecules

PTPRS SDK1 SDK2

2.38e-03313183GO:0098742
GeneOntologyBiologicalProcessnegative regulation of mRNA catabolic process

MEIOC MAPKAPK2

2.58e-0387182GO:1902373
GeneOntologyBiologicalProcesstoll-like receptor signaling pathway

MAPKAPK2 MAPKAPK3

2.63e-0388182GO:0002224
GeneOntologyBiologicalProcessRNA stabilization

MEIOC MAPKAPK2

2.63e-0388182GO:0043489
GeneOntologyBiologicalProcessnucleobase-containing compound catabolic process

MEIOC GIGYF2 MAPKAPK2 NCBP1

2.70e-03696184GO:0034655
GeneOntologyBiologicalProcessretina morphogenesis in camera-type eye

SDK1 SDK2

2.75e-0390182GO:0060042
GeneOntologyBiologicalProcessregulation of translational initiation

GIGYF2 NCBP1

2.81e-0391182GO:0006446
GeneOntologyBiologicalProcessactivation of innate immune response

PTPRS MAPKAPK2 MAPKAPK3

2.84e-03333183GO:0002218
GeneOntologyBiologicalProcessdendrite development

PTPRS SDK1 GRN

2.89e-03335183GO:0016358
GeneOntologyBiologicalProcesscentral nervous system development

NFASC GIGYF2 PTPRS GRN AGER

2.96e-031197185GO:0007417
GeneOntologyBiologicalProcesssensory organ development

SDK1 MAPKAPK2 GRN SDK2

3.20e-03730184GO:0007423
GeneOntologyBiologicalProcessnegative regulation of RNA catabolic process

MEIOC MAPKAPK2

3.45e-03101182GO:1902369
GeneOntologyBiologicalProcessneuroinflammatory response

GRN AGER

3.45e-03101182GO:0150076
GeneOntologyBiologicalProcessneural retina development

SDK1 SDK2

3.52e-03102182GO:0003407
GeneOntologyBiologicalProcessastrocyte differentiation

GRN AGER

3.72e-03105182GO:0048708
GeneOntologyBiologicalProcesspositive regulation of neuron apoptotic process

GRN AGER

4.08e-03110182GO:0043525
GeneOntologyBiologicalProcessnegative regulation of innate immune response

GIGYF2 GRN

4.37e-03114182GO:0045824
GeneOntologyBiologicalProcessnegative regulation of mRNA metabolic process

MEIOC MAPKAPK2

4.45e-03115182GO:1903312
GeneOntologyBiologicalProcessspinal cord development

GIGYF2 PTPRS

4.75e-03119182GO:0021510
DomainI-set

NFASC PTPRS SDK1 AGER NEO1 SDK2

1.72e-08190186PF07679
DomainIg_I-set

NFASC PTPRS SDK1 AGER NEO1 SDK2

1.72e-08190186IPR013098
DomainIg_sub2

NFASC PTPRS SDK1 AGER NEO1 SDK2

6.09e-08235186IPR003598
DomainIGc2

NFASC PTPRS SDK1 AGER NEO1 SDK2

6.09e-08235186SM00408
Domainfn3

NFASC PTPRS SDK1 NEO1 SDK2

3.61e-07162185PF00041
DomainFN3

NFASC PTPRS SDK1 NEO1 SDK2

6.97e-07185185SM00060
DomainFN3

NFASC PTPRS SDK1 NEO1 SDK2

1.00e-06199185PS50853
DomainFN3_dom

NFASC PTPRS SDK1 NEO1 SDK2

1.27e-06209185IPR003961
DomainIg_sub

NFASC PTPRS SDK1 AGER NEO1 SDK2

1.87e-06421186IPR003599
DomainIG

NFASC PTPRS SDK1 AGER NEO1 SDK2

1.87e-06421186SM00409
DomainMAPKAPK_C

MAPKAPK2 MAPKAPK3

2.63e-063182IPR027442
Domain-

MAPKAPK2 MAPKAPK3

2.63e-0631824.10.1170.10
DomainIG_LIKE

NFASC PTPRS SDK1 AGER NEO1 SDK2

4.54e-06491186PS50835
DomainIg-like_dom

NFASC PTPRS SDK1 AGER NEO1 SDK2

5.22e-06503186IPR007110
Domain-

NFASC PTPRS SDK1 AGER NEO1 SDK2

2.52e-056631862.60.40.10
DomainImmunoglobulin

NFASC PTPRS AGER SDK2

2.84e-05190184IPR013151
Domainig

NFASC PTPRS AGER SDK2

2.84e-05190184PF00047
DomainIg-like_fold

NFASC PTPRS SDK1 AGER NEO1 SDK2

3.59e-05706186IPR013783
DomainCa/CaM-dep_Ca-dep_prot_Kinase

MAPKAPK2 MAPKAPK3

1.98e-0369182IPR020636
DomainIg_2

AGER NEO1

2.21e-0373182PF13895
DomainZINC_PROTEASE

ANPEP ADAM29

3.95e-0398182PS00142
PathwayREACTOME_P38MAPK_EVENTS

MAPKAPK2 MAPKAPK3

1.64e-057132MM14672
PathwayREACTOME_SIGNALLING_TO_RAS

MAPKAPK2 MAPKAPK3

5.15e-0512132MM14657
PathwayREACTOME_MYD88_MAL_TIRAP_CASCADE_INITIATED_ON_PLASMA_MEMBRANE

MAPKAPK2 AGER MAPKAPK3

5.79e-0585133MM14645
PathwayREACTOME_P38MAPK_EVENTS

MAPKAPK2 MAPKAPK3

6.09e-0513132M1441
PathwayBIOCARTA_HSP27_PATHWAY

MAPKAPK2 MAPKAPK3

7.10e-0514132M2587
PathwayREACTOME_TOLL_LIKE_RECEPTOR_9_TLR9_CASCADE

MAPKAPK2 AGER MAPKAPK3

9.13e-0599133MM14660
PathwayREACTOME_MYD88_INDEPENDENT_TLR4_CASCADE

MAPKAPK2 AGER MAPKAPK3

1.22e-04109133M29565
PathwayREACTOME_TOLL_LIKE_RECEPTOR_9_TLR9_CASCADE

MAPKAPK2 AGER MAPKAPK3

1.22e-04109133M27012
PathwayREACTOME_INNATE_IMMUNE_SYSTEM

ANPEP NFASC MAPKAPK2 GRN AGER MAPKAPK3

1.36e-04995136MM14661
PathwayREACTOME_TOLL_LIKE_RECEPTOR_TLR1_TLR2_CASCADE

MAPKAPK2 AGER MAPKAPK3

1.43e-04115133M27013
PathwayREACTOME_SIGNALLING_TO_RAS

MAPKAPK2 MAPKAPK3

1.48e-0420132M12256
PathwayPID_P38_MK2_PATHWAY

MAPKAPK2 MAPKAPK3

1.63e-0421132M199
PathwayREACTOME_TOLL_LIKE_RECEPTOR_4_TLR4_CASCADE

MAPKAPK2 AGER MAPKAPK3

1.70e-04122133MM14640
PathwayREACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION

MAPKAPK2 MAPKAPK3

1.96e-0423132M17243
PathwayREACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION

MAPKAPK2 MAPKAPK3

2.14e-0424132MM15133
PathwayREACTOME_SIGNALING_BY_NTRKS

PTPRS MAPKAPK2 MAPKAPK3

2.24e-04134133M3574
PathwayREACTOME_SIGNALLING_TO_ERKS

MAPKAPK2 MAPKAPK3

2.52e-0426132MM14716
PathwayREACTOME_INNATE_IMMUNE_SYSTEM

ANPEP NFASC MAPKAPK2 GRN AGER MAPKAPK3

2.72e-041128136M1036
PathwayREACTOME_TOLL_LIKE_RECEPTOR_CASCADES

MAPKAPK2 AGER MAPKAPK3

3.44e-04155133MM14665
PathwayREACTOME_SIGNALLING_TO_ERKS

MAPKAPK2 MAPKAPK3

4.33e-0434132M13881
PathwayREACTOME_TOLL_LIKE_RECEPTOR_CASCADES

MAPKAPK2 AGER MAPKAPK3

4.51e-04170133M7494
PathwayWP_FAS_PATHWAY_AND_STRESS_INDUCTION_OF_HSP_REGULATION

MAPKAPK2 MAPKAPK3

4.86e-0436132MM15967
PathwayREACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE

MAPKAPK2 MAPKAPK3

5.13e-0437132MM14899
PathwayWP_SEROTONIN_HTR1_GROUP_AND_FOS_PATHWAY

MAPKAPK2 MAPKAPK3

5.13e-0437132M42558
PathwayPID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY

MAPKAPK2 MAPKAPK3

5.42e-0438132M229
PathwayWP_FAS_LIGAND_PATHWAY_AND_STRESS_INDUCTION_OF_HEAT_SHOCK_PROTEINS

MAPKAPK2 MAPKAPK3

7.27e-0444132M39673
PathwayREACTOME_CELL_CELL_JUNCTION_ORGANIZATION

SDK1 SDK2

8.65e-0448132MM15069
PathwayREACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES

PTPRS MAPKAPK2 NCBP1 MAPKAPK3

1.09e-03532134M27870
PathwayREACTOME_INTERLEUKIN_17_SIGNALING

MAPKAPK2 MAPKAPK3

1.30e-0359132MM15128
PathwayREACTOME_SIGNALING_BY_NTRK1_TRKA

MAPKAPK2 MAPKAPK3

1.49e-0363132MM14714
PathwayREACTOME_INTERLEUKIN_17_SIGNALING

MAPKAPK2 MAPKAPK3

1.88e-0371132M27382
PathwayREACTOME_SIGNALING_BY_INTERLEUKINS

MAPKAPK2 AGER MAPKAPK3

1.93e-03281133MM15130
PathwayREACTOME_CELL_JUNCTION_ORGANIZATION

SDK1 SDK2

1.99e-0373132MM15126
PathwayREACTOME_SIGNALING_BY_NTRKS

MAPKAPK2 MAPKAPK3

2.10e-0375132MM14652
PathwayKEGG_VEGF_SIGNALING_PATHWAY

MAPKAPK2 MAPKAPK3

2.15e-0376132M1749
PathwayBIOCARTA_MAPK_PATHWAY

MAPKAPK2 MAPKAPK3

2.44e-0381132M13863
PathwayREACTOME_CELL_CELL_JUNCTION_ORGANIZATION

SDK1 SDK2

3.00e-0390132M820
PathwayREACTOME_CELL_CELL_COMMUNICATION

SDK1 SDK2

3.41e-0396132MM14592
PathwayREACTOME_SIGNALING_BY_VEGF

MAPKAPK2 MAPKAPK3

3.91e-03103132MM14752
PathwayREACTOME_SIGNALING_BY_VEGF

MAPKAPK2 MAPKAPK3

4.14e-03106132M27077
PathwayREACTOME_CELL_JUNCTION_ORGANIZATION

SDK1 SDK2

5.02e-03117132M19248
PathwayREACTOME_CELLULAR_SENESCENCE

MAPKAPK2 MAPKAPK3

5.19e-03119132MM14901
PathwayREACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE

MAPKAPK2 MAPKAPK3

5.71e-03125132M27186
PathwayREACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES

MAPKAPK2 NCBP1 MAPKAPK3

5.93e-03418133MM15587
PathwayKEGG_CELL_ADHESION_MOLECULES_CAMS

NFASC NEO1

6.44e-03133132M16476
PathwayREACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM

MAPKAPK2 AGER MAPKAPK3

8.30e-03472133MM14539
PathwayREACTOME_SIGNALING_BY_INTERLEUKINS

MAPKAPK2 AGER MAPKAPK3

8.35e-03473133M874
PathwayREACTOME_NEUTROPHIL_DEGRANULATION

ANPEP NFASC GRN

8.60e-03478133M27620
PathwayREACTOME_CELL_CELL_COMMUNICATION

SDK1 SDK2

8.65e-03155132M522
PathwayREACTOME_NEUTROPHIL_DEGRANULATION

ANPEP NFASC GRN

1.03e-02511133MM15330
PathwayREACTOME_CELLULAR_SENESCENCE

MAPKAPK2 MAPKAPK3

1.37e-02197132M27188
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

NFASC NCBP1 NEO1

1.42e-02575133M29853
Pubmed

Definition of the critical domains required for homophilic targeting of mouse sidekick molecules.

SDK1 SDK2

2.53e-07218215703275
Pubmed

Architecture of cell-cell adhesion mediated by sidekicks.

SDK1 SDK2

2.53e-07218230150416
Pubmed

MAPKAP kinase 3 suppresses Ifng gene expression and attenuates NK cell cytotoxicity and Th1 CD4 T-cell development upon influenza A virus infection.

MAPKAPK2 MAPKAPK3

2.53e-07218224935968
Pubmed

Pharmacological and genetic inhibition of downstream targets of p38 MAPK in experimental nephrotic syndrome.

MAPKAPK2 MAPKAPK3

2.53e-07218229187369
Pubmed

Crucial roles of the protein kinases MK2 and MK3 in a mouse model of glomerulonephritis.

MAPKAPK2 MAPKAPK3

2.53e-07218223372691
Pubmed

MK2/3 Are Pivotal for IL-33-Induced and Mast Cell-Dependent Leukocyte Recruitment and the Resulting Skin Inflammation.

MAPKAPK2 MAPKAPK3

2.53e-07218227694493
Pubmed

Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina.

SDK1 SDK2

2.53e-07218212230981
Pubmed

Alternative Translation Initiation Generates a Functionally Distinct Isoform of the Stress-Activated Protein Kinase MK2.

MAPKAPK2 MAPKAPK3

2.53e-07218231167133
Pubmed

Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity.

MAPKAPK2 MAPKAPK3

2.53e-07218224082115
Pubmed

Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy.

SDK1 SDK2

2.53e-07218215213259
Pubmed

Molecular basis of sidekick-mediated cell-cell adhesion and specificity.

SDK1 SDK2

2.53e-07218227644106
Pubmed

Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity.

MAPKAPK2 MAPKAPK3

7.59e-07318210781029
Pubmed

Mitogen-activated protein kinase-activated protein kinases 2 and 3 regulate SERCA2a expression and fiber type composition to modulate skeletal muscle and cardiomyocyte function.

MAPKAPK2 MAPKAPK3

7.59e-07318223608535
Pubmed

Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity.

MAPKAPK2 MAPKAPK3

7.59e-07318226068544
Pubmed

A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress.

MAPKAPK2 MAPKAPK3

7.59e-0731828774846
Pubmed

p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins.

MAPKAPK2 MAPKAPK3

7.59e-07318220724476
Pubmed

Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27.

MAPKAPK2 MAPKAPK3

7.59e-0731827799959
Pubmed

Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3.

MAPKAPK2 MAPKAPK3

7.59e-07318221586572
Pubmed

Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2.

MAPKAPK2 MAPKAPK3

7.59e-0731828846784
Pubmed

The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility.

MAPKAPK2 MAPKAPK3

7.59e-07318225134715
Pubmed

IL-3 is essential for ICOS-L stabilization on mast cells, and sustains the IL-33-induced RORγt+ Treg generation via enhanced IL-6 induction.

MAPKAPK2 MAPKAPK3

1.52e-06418233427298
Pubmed

Vascular endothelial cell growth factor activates CRE-binding protein by signaling through the KDR receptor tyrosine kinase.

MAPKAPK2 MAPKAPK3

1.52e-06418211335727
Pubmed

Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction.

MAPKAPK2 MAPKAPK3

1.52e-06418228011639
Pubmed

Distinct roles of MK2 and MK5 in cAMP/PKA- and stress/p38MAPK-induced heat shock protein 27 phosphorylation.

MAPKAPK2 MAPKAPK3

1.52e-06418221575178
Pubmed

IL-33-activated murine mast cells control the dichotomy between RORγt+ and Helios+ Tregs via the MK2/3-mediated IL-6 production in vitro.

MAPKAPK2 MAPKAPK3

1.52e-06418231334837
Pubmed

MAP kinase-activated protein kinases 2 and 3 are required for influenza A virus propagation and act via inhibition of PKR.

MAPKAPK2 MAPKAPK3

2.53e-06518220484669
Pubmed

The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges.

SDK1 SDK2

2.53e-06518234545809
Pubmed

Role of p38alpha Map kinase in Type I interferon signaling.

MAPKAPK2 MAPKAPK3

2.53e-06518214578350
Pubmed

p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection.

MAPKAPK2 MAPKAPK3

2.53e-06518228920954
Pubmed

The Role of TTP Phosphorylation in the Regulation of Inflammatory Cytokine Production by MK2/3.

MAPKAPK2 MAPKAPK3

2.53e-06518231527197
Pubmed

The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways.

MAPKAPK2 MAPKAPK3

2.53e-06518217906627
Pubmed

Expression and Roles of the Immunoglobulin Superfamily Recognition Molecule Sidekick1 in Mouse Retina.

SDK1 SDK2

3.79e-06618230687002
Pubmed

Reporter-nanobody fusions (RANbodies) as versatile, small, sensitive immunohistochemical reagents.

SDK1 SDK2

3.79e-06618229440485
Pubmed

The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.

MAPKAPK2 MAPKAPK3

3.79e-06618217030606
Pubmed

The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation.

MAPKAPK2 MAPKAPK3

3.79e-06618225693418
Pubmed

The IL-33-induced p38-/JNK1/2-TNFα axis is antagonized by activation of β-adrenergic-receptors in dendritic cells.

MAPKAPK2 MAPKAPK3

5.30e-06718232424229
Pubmed

MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells.

MAPKAPK2 MAPKAPK3

7.07e-06818219369945
Pubmed

Differential control of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases.

MAPKAPK2 MAPKAPK3

1.14e-051018229229781
Pubmed

The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ.

MAPKAPK2 MAPKAPK3

1.39e-051118215850461
Pubmed

Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways.

MAPKAPK2 MAPKAPK3

1.66e-051218212171600
Pubmed

Ras effectors and their role in mitogenesis and oncogenesis.

MAPKAPK2 MAPKAPK3

1.66e-05121829297626
Pubmed

TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.

R3HDM2 GRN NEO1 SDK2

3.88e-0538218437249651
Pubmed

Sidekick 2 directs formation of a retinal circuit that detects differential motion.

SDK1 SDK2

6.36e-052318226287463
Pubmed

Nerve growth factor signaling, neuroprotection, and neural repair.

MAPKAPK2 MAPKAPK3

8.16e-052618211520933
Pubmed

Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice.

NEO1 ASIC5

1.67e-043718216707424
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

ANPEP SDK1 NEO1

1.75e-0421418322199357
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

ANPEP PTPRS NEO1

3.00e-0425718316335952
Pubmed

An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.

SDK1 SDK2

3.30e-045218226633812
InteractionRYK interactions

PTPRS SDK1 NEO1 SDK2

3.24e-05212184int:RYK
CytobandEnsembl 112 genes in cytogenetic band chr1q32

NFASC MAPKAPK2

5.69e-03290182chr1q32
GeneFamilyFibronectin type III domain containing

NFASC PTPRS SDK1 NEO1 SDK2

9.57e-08160145555
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

NFASC PTPRS SDK1 NEO1 SDK2

9.87e-08161145593
GeneFamilyImmunoglobulin like domain containing

SDK1 AGER NEO1 SDK2

1.16e-05193144594
GeneFamilyMitogen-activated protein kinase-activated protein kinases

MAPKAPK2 MAPKAPK3

3.05e-05111421156
CoexpressionGSE29618_BCELL_VS_PDC_DAY7_FLU_VACCINE_DN

PTPRS MAPKAPK2 GRN MAPKAPK3

8.90e-06198184M4959
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

NFASC PTPRS SDK1 SDK2

9.58e-07193184b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCell(1)_Control_(PBS)-(4)_COL2.3+_osteoblasts|World / Stress and Cell class

ANPEP PTPRS NEO1

3.46e-05160183ab769516f9f7798d1390ef215caf22a2d3d53e63
ToppCellfacs-Marrow-T-cells-24m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRS SDK1 GRN

4.37e-05173183ca3d2a9562734f76127e3e7d54c10b63e95141bb
ToppCellfacs-Marrow-T-cells-24m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRS SDK1 GRN

4.37e-0517318319a9e10885173d7712996be8660a3a5a7a9aa39f
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NFASC SDK1 SDK2

4.84e-05179183a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCell(2)_5-FU-(4)_COL2.3+_osteoblasts|(2)_5-FU / Stress and Cell class

ANPEP PTPRS NEO1

5.00e-0518118356ae86072858c156681507aecd1bc6cb0a3372d2
ToppCell(2)_5-FU-(4)_COL2.3+_osteoblasts|World / Stress and Cell class

ANPEP PTPRS NEO1

5.25e-05184183684d05340a3dfb8aa08b881516a37f9627a10448
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-3|TCGA-Lung / Sample_Type by Project: Shred V9

PTPRS SDK1 SDK2

5.25e-05184183ea4ccebe2d54279fcc517e4f0bfa652b91a808bb
ToppCell(7)_MNP-(7)_DC_plasmacytoid|(7)_MNP / Spleen cell shreds - cell class (v1) and cell subclass (v1)

PTPRS MAPKAPK2 SDK2

5.33e-051851839f67f652488e17075a372e2a2e1100f6d0af6d7d
ToppCellMultiple_Sclerosis-Myeloid-pDC|Multiple_Sclerosis / Disease, Lineage and Cell Type

PTPRS MAPKAPK2 GRN

5.42e-05186183330a4f669adea91ff9f2dff2de2210f5e3401e19
ToppCellhealthy_donor-Lymphocytic-Dendritic|healthy_donor / Disease condition, Lineage, Cell class and subclass

PTPRS MAPKAPK2 GRN

5.42e-05186183916f2aeea4989ba7a29e071e348a51010f010223
ToppCellhealthy_donor-Lymphocytic-Dendritic-pDC|healthy_donor / Disease condition, Lineage, Cell class and subclass

PTPRS MAPKAPK2 GRN

5.42e-0518618345f66619e45d590c7365a51782d4ac46b7d31fde
ToppCellIIH-pDC-|IIH / Condition, Cell_class and T cell subcluster

PTPRS MAPKAPK2 GRN

5.51e-05187183ad87b146ea8dd9f695e722f8f0e8e1057c7f3167
ToppCellIIH-pDC|IIH / Condition, Cell_class and T cell subcluster

PTPRS MAPKAPK2 GRN

5.51e-051871835e59e9153a18bcfb5c8dc94599080216661de7ce
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

NFASC PTPRS SDK1

5.51e-0518718392d468dde81125d51daf7abd4703741abe1ab91c
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPRS SDK1 SDK2

5.68e-051891832a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell3'_v3-bone_marrow-Myeloid_Dendritic-pDC|bone_marrow / Manually curated celltypes from each tissue

PTPRS MAPKAPK2 SDK2

5.77e-05190183dde0e34f6a06cdbbb65c86472360c09f0279a572
ToppCell3'_v3-bone_marrow-Myeloid_Dendritic|bone_marrow / Manually curated celltypes from each tissue

PTPRS MAPKAPK2 SDK2

5.77e-051901836892c603037b61ef88d6ca01b7592dc0d347d63b
ToppCellControl-Myeloid-pDC|Control / Disease, Lineage and Cell Type

PTPRS MAPKAPK2 GRN

5.86e-05191183473f904fe244d919ce561139591a2be12cc9fa6b
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NFASC PTPRS SDK1

5.86e-051911836688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCellBLOOD--(3)_DC_(cDC+pDC)| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PTPRS MAPKAPK2 GRN

5.96e-05192183e290c55a1321e9e577f49e8ba20501b2c8150044
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NFASC PTPRS SDK1

5.96e-0519218399ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCellMesenchymal-matrix_fibroblast_1_cell|World / Lineage, Cell type, age group and donor

PTPRS SDK1 SDK2

6.05e-05193183acad568621ed677031797b8c2e34dafea798d681
ToppCellVE-pDC-|VE / Condition, Cell_class and T cell subcluster

PTPRS MAPKAPK2 GRN

6.05e-05193183583724de588fcde3aeda056138c522dc0225a387
ToppCellVE-pDC|VE / Condition, Cell_class and T cell subcluster

PTPRS MAPKAPK2 GRN

6.05e-05193183bb759dc9ef0ec41d655002f59021d62d62d44289
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D231|Adult / Lineage, Cell type, age group and donor

NFASC PTPRS SDK1

6.05e-05193183ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPRS SDK1 SDK2

6.14e-0519418360622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell|Adult / Lineage, Cell type, age group and donor

NFASC PTPRS SDK1

6.24e-0519518361c9e09fc84d1012e472185d70ad0a06cee30d6e
ToppCellCOVID-19-Fibroblasts-Alveolar_FB|COVID-19 / group, cell type (main and fine annotations)

NFASC PTPRS SDK1

6.24e-05195183603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D122|Adult / Lineage, Cell type, age group and donor

NFASC PTPRS SDK1

6.24e-05195183aa0add081881d349099d12efca5cdee098038d4e
ToppCellnucseq-Mesenchymal-Fibroblastic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NFASC PTPRS SDK1

6.33e-051961837d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCelldistal-Hematologic-Plasmacytoid_Dendritic-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PTPRS MAPKAPK2 SDK2

6.43e-051971833a5908deb5c5a2bf06019a102fb1652233cf2a2a
ToppCellnucseq-Mesenchymal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NFASC PTPRS SDK1

6.52e-051981838f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCellSepsis-ICU-SEP-Myeloid-pDC|ICU-SEP / Disease, condition lineage and cell class

PTPRS MAPKAPK2 SDK2

6.52e-05198183fe8a68bff8c1b9566eee4bfcab564f206a20ae7b
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Classical_Monocyte-Mono_c2-CD14-HLA-DPB1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANPEP GRN MAPKAPK3

6.52e-05198183c26c909e95225440abdf558b1b858ffc06177000
ToppCellAdult-Mesenchymal|Adult / Lineage, Cell type, age group and donor

NFASC PTPRS SDK1

6.52e-0519818326e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCellMS-Multiple_Sclerosis-Myeloid-pDC|Multiple_Sclerosis / Disease, condition lineage and cell class

PTPRS MAPKAPK2 GRN

6.62e-05199183c10c8c9322cad4996e4aa11a8680e3d781644ace
ToppCellNS-control-d_0-4-Epithelial-Secretory|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ANPEP PTPRS GRN

6.62e-0519918332bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCellMS-IIF-Myeloid-pDC|IIF / Disease, condition lineage and cell class

PTPRS MAPKAPK2 GRN

6.62e-05199183e262ee854e64d87460bee810c14d6cbe744460e8
ToppCellcontrol-Epithelial-Secretory|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ANPEP PTPRS GRN

6.62e-051991833d01f90ffd271ca00129192787e4921bdca7e01e
ToppCellcontrol-Epithelial-Secretory|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ANPEP PTPRS GRN

6.62e-05199183262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCellnormal_Lung-B_lymphocytes-GrB-secreting_B_cells|B_lymphocytes / Location, Cell class and cell subclass

PTPRS MAPKAPK2 GRN

6.62e-051991832f6074a2fd3323f258be03042f77929640ad0a75
ToppCellParenchyma_Control_(B.)-Stromal-TX-Fibroblasts-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

NFASC PTPRS SDK2

6.72e-05200183aa1a35dcca3b799241eef4237f6eb94660e019f0
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Monocytic|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANPEP GRN MAPKAPK3

6.72e-052001839e8659bbc6547f1ab7f4e0a81b0bcbe158e9e2f7
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFASC PTPRS SDK1

6.72e-05200183311fab076f2ceb258e3970eb21e39344b894042a
ToppCellParenchymal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFASC PTPRS SDK1

6.72e-05200183cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFASC PTPRS SDK1

6.72e-0520018334f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

NFASC PTPRS SDK2

6.72e-05200183a510deaada669e690329183e18df02870bd204b3
ToppCellBronchial-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFASC PTPRS SDK1

6.72e-05200183389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFASC PTPRS SDK1

6.72e-05200183e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NFASC PTPRS SDK2

6.72e-05200183dd4228cbed8a4395166a6332e08d44d88bebe3b9
ToppCellHippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Kcnj8_(Mural.Rgs5Acta2.Kcnj8)|Hippocampus / BrainAtlas - Mouse McCarroll V32

ANPEP AGER

6.06e-049118278e2e65beb15bf1e251974c72fbcfab817492772
ToppCellHippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Kcnj8_(Mural.Rgs5Acta2.Kcnj8)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

ANPEP AGER

6.06e-0491182f59908093416ca7b3ca27019d71c79acbdea18cb
ToppCellHippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2|Hippocampus / BrainAtlas - Mouse McCarroll V32

ANPEP AGER

6.06e-0491182104d2ab9fe5cc404388c32fafb34e421c2e138be
ToppCellStriatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Ccnd1_(Mural.Rgs5Acta2.Ccnd1)|Striatum / BrainAtlas - Mouse McCarroll V32

ANPEP AGER

6.74e-0496182d98df92856840602a82d3f050bf0a1543445cac0
ToppCellStriatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Ccnd1_(Mural.Rgs5Acta2.Ccnd1)-|Striatum / BrainAtlas - Mouse McCarroll V32

ANPEP AGER

6.74e-0496182bf62c29da66aa3eefdc59337dfb3cd0467f04f10
ToppCell368C-Epithelial_cells-Epithelial-B_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SDK1 SDK2

8.36e-041071825bae4b3aede9bcbf7e88414e3453973cc8b0c3e7
ToppCell368C-Epithelial_cells-Epithelial-B_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SDK1 SDK2

8.36e-04107182410b37beffaf637a2a64c9d0ce7baf81f4bc667c
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_2-Endothelial_Tip.Dcn.1500015O10Rik_(1500015O10Rik)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MEIOC ASIC5

9.48e-04114182c3feca81edee445cbe5e46a07e1a59327dc2e981
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_2-Endothelial_Tip.Dcn.1500015O10Rik_(1500015O10Rik)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MEIOC ASIC5

9.48e-0411418289350483d2ce57afc612fe25398e35af121d50f0
ToppCellEntopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Pdgfa_(Mural.Rgs5Acta2.Pdgfa)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ANPEP AGER

9.48e-04114182fceb7cc590a47380145fc0d854c9f2350dbb0a59
ToppCellEntopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Pdgfa_(Mural.Rgs5Acta2.Pdgfa)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ANPEP AGER

9.48e-041141822cc5d2da5573650c5232a01e2d2128082c4bffcb
ToppCellPBMC-Control-Hematopoietic-Platelet-Platelet-plt_5|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MEIOC NFASC

1.34e-0313618288b5c839d0446c6d6b7e81fc4d48f5e7e96eea11
ToppCellPBMC-Control-Hematopoietic-Platelet-Platelet-plt_5|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MEIOC NFASC

1.34e-0313618227a41463e6f16deb5b1d4f17fefded9959038c07
ToppCellCTRL-Lymphoid-pDC|CTRL / Disease state, Lineage and Cell class

PTPRS SDK2

1.40e-03139182bbc10812b0c5b8c85e78171c12316becde8895c3
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ANPEP SDK1

1.42e-03140182e16e31d6310347f1fe72051dd0d7650d090e6d3c
ToppCellParenchymal-10x3prime_v2-Stromal-Pericyte-Muscle_pericyte_systemic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ZSCAN21 AGER

1.44e-03141182dcc56aef1b31bfe0de84cb0b5c77d242681cf19c
ToppCellfacs-Marrow-B-cells-24m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRS GRN

1.57e-031471829d7e965fe61bd7b31e09c4b2129a5a98c36f4811
ToppCellfacs-Marrow-B-cells-24m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRS GRN

1.57e-0314718238552953ff65a0fc20bee6ef57dc5885306ad18b
ToppCellASK454-Epithelial-Type_1|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

GRN AGER

1.61e-03149182078792d5272f1881757dc47daa96e87449cf5d34
ToppCellFrontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

R3HDM2 SDK2

1.63e-031501829d5bbdca19da60e1a2121ef64ec8e1375a5dbf6d
ToppCellInt-URO-Other|Int-URO / Disease, Lineage and Cell Type

PTPRS SDK2

1.65e-03151182ea5f25842e621be41a6491c9959d419d9cc7ebd6
ToppCellInt-URO-Other-RBC|Int-URO / Disease, Lineage and Cell Type

PTPRS SDK2

1.65e-031511820344d482f1c55c9eaa15beb8d6bac1c6cdca21b3
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

MEIOC ZSCAN21

1.67e-031521825adcdf93fd3ca066402aaaf308c363e4648f871d
ToppCellP07-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SDK1 AGER

1.70e-031531825501095bcf73080872ae01128f21399f9cfc5dd1
ToppCelldroplet-Kidney-nan-18m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AGER MAPKAPK3

1.78e-03157182eb64a4e89843895d16015c7d51805f164ed7ea5b
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Macrophage|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANPEP GRN

1.81e-031581821635a85fc73c544028418087f36d28957dd4f458
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANPEP GRN

1.81e-0315818280841dadfa53bcde36a3e486408a095f78e772eb
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_4|368C / Donor, Lineage, Cell class and subclass (all cells)

ANPEP GRN

1.81e-03158182f9cfb110342be3c91aba9914805332f22ba89101
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1-41|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

R3HDM2 SDK2

1.81e-031581826d2709b387945c015faa223c20d22b52a4082140
ToppCellBronchial_Brush-Epithelial-Goblet_1|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

ANPEP GRN

1.83e-03159182a8fa49dc2e6ad726d1f4f2b30693fecd1151a485
ToppCellAdult-Mesenchymal-chondrocyte|Adult / Lineage, Cell type, age group and donor

PTPRS SDK2

1.83e-031591823f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCellBronchial_Brush-Epithelial-Goblet_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

ANPEP GRN

1.83e-0315918295834b767cfb4fb8c5aeea89c10f3e14a1fd15c1
ToppCellRV-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

NFASC SDK1

1.85e-0316018229c9b4770d0e73d59cffc7937b179484c76b6dcc
ToppCellCOVID_non-vent-Lymphocytic-Dendritic-pDC|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

PTPRS MAPKAPK2

1.85e-0316018261f4cb4eb4313d8318aadbb99595a6cb7fd919f7
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SDK1 SDK2

1.85e-031601826215ac6123a295f3c2f033786602a57b2e2e1177
ToppCellBasal_cells-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

PTPRS SDK2

1.85e-03160182b223cc47e68a29df4758c5ccf8f6dbffe2a6fa1d
ToppCellCOVID_non-vent-Lymphocytic-Dendritic|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

PTPRS MAPKAPK2

1.85e-0316018234b4f710cfcb6ec370b8b074f3cbfe272f392cec
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MEIOC SDK2

1.85e-03160182174a4ab27114efcc63be36929b80680be3c35c9b
ToppCellPND28-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANPEP SDK1

1.88e-0316118276c993a4533362db2250c88b3ee3ede55362d54e
ToppCell10x5'-bone_marrow-Myeloid_Dendritic-DC1|bone_marrow / Manually curated celltypes from each tissue

ANPEP GRN

1.88e-031611822f068ee643de2f647c289779a6624265ab9a749b
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANPEP ADAM29

1.88e-031611824362fe0c151f49eae7372b9673bac64d980a8389
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage_4|343B / Donor, Lineage, Cell class and subclass (all cells)

ANPEP GRN

1.88e-031611825cd483b73bcb3615ea56eb81c1c293e61b84b66d
ToppCelldroplet-Thymus-nan-21m-Myeloid-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANPEP GRN

1.88e-03161182441ebd3c029861d833fbcf8a68fc740d9de8ef2f
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SDK1 GRN

1.90e-03162182ec29c6f1c31e41ddcb041a49c593910edaf0532c
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AGER MAPKAPK3

1.90e-0316218234b4cd3d2258f88dfbd6d32abd1db87aff8a6b6f
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-D|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ANPEP ZSCAN21

1.92e-031631824be3158f2a0ab460cfea8080a7370922910b5da9
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANPEP ADAM29

1.94e-031641827077683afee91828ad2b95e0f81c2b27aae0f831
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage|343B / Donor, Lineage, Cell class and subclass (all cells)

ANPEP GRN

1.94e-03164182057ca87847373eff7fe97dd9f4358509e66ca4c3
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANPEP ADAM29

1.94e-0316418210741c7706a37b24aa08a300b27d60d6b8600167
Diseaseanxiety disorder, stress-related disorder

GIGYF2 SDK1

2.31e-0512182EFO_0006788, EFO_0010098
Diseaseatherosclerosis (is_marker_for)

GRN AGER

2.31e-0437182DOID:1936 (is_marker_for)
DiseaseDrug-induced agranulocytosis, response to clozapine

NFASC AGER

2.98e-0442182GO_0097338, HP_0012235
DiseaseHepatic fibrosis

SDK1 SDK2

4.06e-0449182HP_0001395
Diseaseconotruncal heart malformations

NFASC ADAM29

2.17e-03114182MONDO_0016581
DiseaseTinnitus

SDK1 ADAM29

2.81e-03130182HP_0000360
DiseaseAlzheimer's disease (is_implicated_in)

GRN AGER

2.90e-03132182DOID:10652 (is_implicated_in)
Diseaseglycine measurement

ANPEP R3HDM2

3.12e-03137182EFO_0009767

Protein segments in the cluster

PeptideGeneStartEntry
HELPPQSQPWVMPSQ

ADAM29

726

Q9UKF5
EQGPHQVPWMEKAPA

GRN

336

P28799
FKQWMENPNNNPIHP

ANPEP

776

P15144
PQPPQNPSMVQWSHC

R3HDM2

716

Q9Y2K5
VPAQPSPQIHWMKDG

AGER

261

Q15109
NHPWIMQSTKVPQTP

MAPKAPK2

321

P49137
HPWINQSMVVPQTPL

MAPKAPK3

301

Q16644
VPMLQVWTADKPHPQ

NCBP1

211

Q09161
MEPEHPVGNWQKHNV

PTPRS

466

Q13332
NGNPKPTVQWMVNGE

NFASC

361

O94856
PHQNQWTVCRPMKEP

KLHL28

501

Q9NXS3
PPQQPQQQDSVWGMN

GIGYF2

1221

Q6Y7W6
QNPWQPKPHVLDMQG

C4orf45

116

Q96LM5
KISEMTQWTPPPQNH

ASIC5

481

Q9NY37
MVQWQPPPETEHNGV

SDK1

786

Q7Z5N4
SIMIQWQPPPESHQN

SDK2

706

Q58EX2
PTWMNVQTKNNTPIP

MEIOC

476

A2RUB1
MIHWQPPAPATQNGQ

NEO1

651

Q92859
GHQVSTPPNEQKPVW

ZSCAN21

131

Q9Y5A6
VWQPTKGQMPHQPEQ

nan

661

Q3C1V9