Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	insulin receptor activity	IGF1R INSR	6.54e-06	3	30	2	GO:0005009
GeneOntologyMolecularFunction	insulin binding	IGF1R INSR	2.18e-05	5	30	2	GO:0043559
GeneOntologyMolecularFunction	insulin-like growth factor I binding	IGF1R INSR	1.68e-04	13	30	2	GO:0031994
GeneOntologyMolecularFunction	insulin receptor substrate binding	IGF1R INSR	2.26e-04	15	30	2	GO:0043560
GeneOntologyMolecularFunction	insulin-like growth factor binding	IGF1R INSR	3.67e-04	19	30	2	GO:0005520
GeneOntologyMolecularFunction	hormone binding	IGF1R NRDC INSR	4.89e-04	103	30	3	GO:0042562
GeneOntologyMolecularFunction	protein-hormone receptor activity	IGF1R INSR	4.95e-04	22	30	2	GO:0016500
GeneOntologyMolecularFunction	bitter taste receptor activity	TAS2R43 TAS2R46	7.48e-04	27	30	2	GO:0033038
GeneOntologyMolecularFunction	taste receptor activity	TAS2R43 TAS2R46	1.12e-03	33	30	2	GO:0008527
GeneOntologyMolecularFunction	growth factor binding	IGF1R NRDC INSR	1.63e-03	156	30	3	GO:0019838
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase binding	IGF1R INSR	1.90e-03	43	30	2	GO:0043548
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	ITPKC IGF1R DCK STK17B SELENOO INSR	2.38e-03	938	30	6	GO:0016772
GeneOntologyMolecularFunction	peptide hormone binding	IGF1R INSR	3.08e-03	55	30	2	GO:0017046
GeneOntologyMolecularFunction	metallopeptidase activity	EEF1AKMT4-ECE2 CPXM1 NRDC	3.29e-03	200	30	3	GO:0008237
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	ITPKC IGF1R DCK STK17B INSR	3.79e-03	709	30	5	GO:0016773
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	IGF1R INSR	4.28e-03	65	30	2	GO:0004714
GeneOntologyMolecularFunction	kinase activity	ITPKC IGF1R DCK STK17B INSR	5.21e-03	764	30	5	GO:0016301
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	IGF1R INSR	7.21e-03	85	30	2	GO:0019199
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	CD79A IGF1R TAS2R43 TAS2R46 PLXNB3 INSR	1.39e-02	1353	30	6	GO:0004888
GeneOntologyMolecularFunction	metalloendopeptidase activity	EEF1AKMT4-ECE2 NRDC	1.40e-02	120	30	2	GO:0004222
GeneOntologyMolecularFunction	PDZ domain binding	LLGL2 KIDINS220	1.46e-02	123	30	2	GO:0030165
GeneOntologyCellularComponent	insulin receptor complex	IGF1R INSR	1.19e-05	4	30	2	GO:0005899
GeneOntologyCellularComponent	receptor complex	CD79A IGF1R PLXNB3 TRAV22 INSR	1.31e-03	581	30	5	GO:0043235
GeneOntologyCellularComponent	plasma membrane signaling receptor complex	CD79A IGF1R TRAV22 INSR	1.50e-03	350	30	4	GO:0098802
Domain	Tyr_kinase_insulin-like_rcpt	IGF1R INSR	6.03e-06	3	27	2	IPR016246
Domain	Furin-like	IGF1R INSR	4.21e-05	7	27	2	PF00757
Domain	Rcpt_L-dom	IGF1R INSR	4.21e-05	7	27	2	IPR000494
Domain	Furin-like_Cys-rich_dom	IGF1R INSR	4.21e-05	7	27	2	IPR006211
Domain	Recep_L_domain	IGF1R INSR	4.21e-05	7	27	2	PF01030
Domain	-	IGF1R INSR	4.21e-05	7	27	2	3.80.20.20
Domain	Tyr_kinase_rcpt_2_CS	IGF1R INSR	1.10e-04	11	27	2	IPR002011
Domain	RECEPTOR_TYR_KIN_II	IGF1R INSR	1.32e-04	12	27	2	PS00239
Domain	Furin_repeat	IGF1R INSR	3.04e-04	18	27	2	IPR006212
Domain	FU	IGF1R INSR	3.04e-04	18	27	2	SM00261
Domain	TAS2R	TAS2R43 TAS2R46	6.40e-04	26	27	2	PF05296
Domain	T2R	TAS2R43 TAS2R46	6.40e-04	26	27	2	IPR007960
Domain	TyrKc	IGF1R INSR	7.14e-03	88	27	2	SM00219
Domain	Tyr_kinase_cat_dom	IGF1R INSR	7.14e-03	88	27	2	IPR020635
Domain	PROTEIN_KINASE_TYR	IGF1R INSR	8.61e-03	97	27	2	PS00109
Domain	Tyr_kinase_AS	IGF1R INSR	8.61e-03	97	27	2	IPR008266
Domain	-	CD79A IGF1R PLXNB3 INSR	1.44e-02	663	27	4	2.60.40.10
Domain	Pkinase_Tyr	IGF1R INSR	1.48e-02	129	27	2	PF07714
Domain	Ser-Thr/Tyr_kinase_cat_dom	IGF1R INSR	1.69e-02	138	27	2	IPR001245
Domain	Protein_kinase_ATP_BS	IGF1R STK17B INSR	1.69e-02	379	27	3	IPR017441
Domain	Ig-like_fold	CD79A IGF1R PLXNB3 INSR	1.78e-02	706	27	4	IPR013783
Pathway	BIOCARTA_HDAC_PATHWAY	IGF1R INSR	4.04e-04	25	17	2	M1547
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_UBIQUITINATION_OF_RTK_BY_CBL	IGF1R INSR	4.04e-04	25	17	2	M47934
Pathway	BIOCARTA_HDAC_PATHWAY	IGF1R INSR	4.37e-04	26	17	2	MM1371
Pathway	WP_GROWTH_FACTORS_AND_HORMONES_IN_BETA_CELL_PROLIFERATION	IGF1R INSR	4.37e-04	26	17	2	M48092
Pathway	REACTOME_SENSORY_PERCEPTION_OF_TASTE	TAS2R43 TAS2R46	6.24e-04	31	17	2	MM15691
Pathway	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	TAS2R43 TAS2R46	8.89e-04	37	17	2	MM15067
Pathway	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	TAS2R43 TAS2R46	9.88e-04	39	17	2	M793
Pubmed	A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer.	IGF1R INSR	7.69e-07	2	31	2	21908557
Pubmed	A novel approach to identify two distinct receptor binding surfaces of insulin-like growth factor II.	IGF1R INSR	7.69e-07	2	31	2	19139090
Pubmed	Heterodimerization of glycosylated insulin-like growth factor-1 receptors and insulin receptors in cancer cells sensitive to anti-IGF1R antibody.	IGF1R INSR	7.69e-07	2	31	2	22438913
Pubmed	Apolipoprotein C3 and circulating mediators of preadipocyte proliferation in states of lipodystrophy.	IGF1R INSR	7.69e-07	2	31	2	35964946
Pubmed	Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization.	IGF1R INSR	7.69e-07	2	31	2	12813019
Pubmed	Insulin/IGF-1 hybrid receptor expression on human platelets: consequences for the effect of insulin on platelet function.	IGF1R INSR	7.69e-07	2	31	2	19817984
Pubmed	Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy.	IGF1R INSR	7.69e-07	2	31	2	19744489
Pubmed	Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor.	IGF1R INSR	7.69e-07	2	31	2	28065828
Pubmed	Epigenetic DNA methylation in the promoters of the Igf1 receptor and insulin receptor genes in db/db mice.	IGF1R INSR	7.69e-07	2	31	2	21474992
Pubmed	Endothelial Cell Mediated Promotion of Ciliated Cell Differentiation of Human Airway Basal Cells via Insulin and Insulin-Like Growth Factor 1 Receptor Mediated Signaling.	IGF1R INSR	7.69e-07	2	31	2	28050756
Pubmed	Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior.	IGF1R INSR	7.69e-07	2	31	2	30765523
Pubmed	Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.	IGF1R INSR	7.69e-07	2	31	2	16642022
Pubmed	Functional collaboration of insulin-like growth factor-1 receptor (IGF-1R), but not insulin receptor (IR), with acute GH signaling in mouse calvarial cells.	IGF1R INSR	7.69e-07	2	31	2	24302626
Pubmed	IGF1R Expression in Ovarian Granulosa Cells Is Essential for Steroidogenesis, Follicle Survival, and Fertility in Female Mice.	IGF1R INSR	7.69e-07	2	31	2	28407051
Pubmed	Obesity and intestinal epithelial deletion of the insulin receptor, but not the IGF 1 receptor, affect radiation-induced apoptosis in colon.	IGF1R INSR	7.69e-07	2	31	2	26251471
Pubmed	Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis.	IGF1R INSR	7.69e-07	2	31	2	25981038
Pubmed	Novel nuclear localization and potential function of insulin-like growth factor-1 receptor/insulin receptor hybrid in corneal epithelial cells.	IGF1R INSR	7.69e-07	2	31	2	22879999
Pubmed	BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis.	IGF1R INSR	7.69e-07	2	31	2	26438154
Pubmed	Insulin and IGF-1 have both overlapping and distinct effects on CD4+ T cell mitochondria, metabolism, and function.	IGF1R INSR	7.69e-07	2	31	2	38383709
Pubmed	Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.	IGF1R INSR	7.69e-07	2	31	2	23671263
Pubmed	Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling.	IGF1R INSR	7.69e-07	2	31	2	36548088
Pubmed	Oncogenic functions of IGF1R and INSR in prostate cancer include enhanced tumor growth, cell migration and angiogenesis.	IGF1R INSR	7.69e-07	2	31	2	24809298
Pubmed	Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function.	IGF1R INSR	7.69e-07	2	31	2	17189427
Pubmed	Suppression of Cardiac Autophagy by Hyperinsulinemia in Insulin Receptor-Deficient Hearts Is Mediated by Insulin-Like Growth Factor Receptor Signaling.	IGF1R INSR	7.69e-07	2	31	2	31088290
Pubmed	Development of a Quantitative PCR Assay for Detection of Human Insulin-Like Growth Factor Receptor and Insulin Receptor Isoforms.	IGF1R INSR	7.69e-07	2	31	2	26862994
Pubmed	Differential effects of IGF-I, IGF-II and insulin in human preadipocytes and adipocytes--role of insulin and IGF-I receptors.	IGF1R INSR	7.69e-07	2	31	2	21524684
Pubmed	Human microvascular endothelial cells are sensitive to IGF-I but resistant to insulin at the receptor level.	IGF1R INSR	7.69e-07	2	31	2	18708119
Pubmed	A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis.	IGF1R INSR	7.69e-07	2	31	2	21139139
Pubmed	The insulin and IGF1 receptor kinase domains are functional dimers in the activated state.	IGF1R INSR	7.69e-07	2	31	2	25758790
Pubmed	Role of insulin receptor in the regulation of glucose uptake in neonatal hepatocytes.	IGF1R INSR	7.69e-07	2	31	2	16644916
Pubmed	[Effects of insulin on expression of insulin receptor and insulin-like growth factor-1 receptor and proliferation in Reh cells].	IGF1R INSR	7.69e-07	2	31	2	22541124
Pubmed	The signaling potential of the receptors for insulin and insulin-like growth factor I (IGF-I) in 3T3-L1 adipocytes: comparison of glucose transport activity, induction of oncogene c-fos, glucose transporter mRNA, and DNA-synthesis.	IGF1R INSR	7.69e-07	2	31	2	1660482
Pubmed	Insulin and IGF1 receptors in human cardiac microvascular endothelial cells: metabolic, mitogenic and anti-inflammatory effects.	IGF1R INSR	7.69e-07	2	31	2	22825921
Pubmed	A functional assessment of insulin/insulin-like growth factor-I hybrid receptors.	IGF1R INSR	7.69e-07	2	31	2	7895674
Pubmed	Insulin receptor and IGF1R are not required for oocyte growth, differentiation, and maturation in mice.	IGF1R INSR	7.69e-07	2	31	2	19851056
Pubmed	Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.	CD79A KIDINS220	7.69e-07	2	31	2	26324445
Pubmed	Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes.	IGF1R INSR	7.69e-07	2	31	2	25246545
Pubmed	Combined and individual tumor-specific expression of insulin-like growth factor-I receptor, insulin receptor and phospho-insulin-like growth factor-I receptor/insulin receptor in primary breast cancer: Implications for prognosis in different treatment groups.	IGF1R INSR	7.69e-07	2	31	2	28030849
Pubmed	Targeting Insulin Receptor in Breast Cancer Using Small Engineered Protein Scaffolds.	IGF1R INSR	7.69e-07	2	31	2	28468775
Pubmed	Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change.	IGF1R INSR	7.69e-07	2	31	2	19835884
Pubmed	Compounds from the marine sponge Cribrochalina vasculum offer a way to target IGF-1R mediated signaling in tumor cells.	IGF1R INSR	7.69e-07	2	31	2	27384680
Pubmed	Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart.	IGF1R INSR	7.69e-07	2	31	2	35786404
Pubmed	Lipodystrophy Due to Adipose Tissue-Specific Insulin Receptor Knockout Results in Progressive NAFLD.	IGF1R INSR	7.69e-07	2	31	2	27207510
Pubmed	Insulin-Mediated Signaling Facilitates Resistance to PDGFR Inhibition in Proneural hPDGFB-Driven Gliomas.	IGF1R INSR	7.69e-07	2	31	2	28138037
Pubmed	The expression and role of hybrid insulin/insulin-like growth factor receptor type 1 in endometrial carcinoma cells.	IGF1R INSR	7.69e-07	2	31	2	20620597
Pubmed	Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function.	IGF1R INSR	7.69e-07	2	31	2	27207537
Pubmed	Insulin-like growth factor type 1 receptor and insulin receptor isoform expression and signaling in mammary epithelial cells.	IGF1R INSR	7.69e-07	2	31	2	19406949
Pubmed	Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis.	IGF1R INSR	7.69e-07	2	31	2	27905925
Pubmed	Thyrocyte-specific deletion of insulin and IGF-1 receptors induces papillary thyroid carcinoma-like lesions through EGFR pathway activation.	IGF1R INSR	7.69e-07	2	31	2	30070361
Pubmed	Reduced insulin-like growth factor I receptor and altered insulin receptor isoform mRNAs in normal mucosa predict colorectal adenoma risk.	IGF1R INSR	7.69e-07	2	31	2	25017244
Pubmed	Differential expression of IGF-I and insulin receptor isoforms in HPV positive and negative human cervical cancer cell lines.	IGF1R INSR	7.69e-07	2	31	2	18711691
Pubmed	Placental glycogen stores are increased in mice with H19 null mutations but not in those with insulin or IGF type 1 receptor mutations.	IGF1R INSR	7.69e-07	2	31	2	19524295
Pubmed	Mice lacking insulin or insulin-like growth factor 1 receptors in vascular endothelial cells maintain normal blood-brain barrier.	IGF1R INSR	7.69e-07	2	31	2	15063759
Pubmed	Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation.	IGF1R INSR	7.69e-07	2	31	2	18650937
Pubmed	Genotype-Structure-Phenotype Correlations of Disease-Associated IGF1R Variants and Similarities to Those of INSR Variants.	IGF1R INSR	7.69e-07	2	31	2	34074726
Pubmed	Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes.	IGF1R INSR	7.69e-07	2	31	2	31562314
Pubmed	Differential Expression of IR-A, IR-B and IGF-1R in Endometrial Physiology and Distinct Signature in Adenocarcinoma.	IGF1R INSR	7.69e-07	2	31	2	27088794
Pubmed	A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding.	IGF1R INSR	7.69e-07	2	31	2	30213860
Pubmed	Insulin-like growth factor I receptors are more abundant than insulin receptors in human micro- and macrovascular endothelial cells.	IGF1R INSR	7.69e-07	2	31	2	14722023
Pubmed	Epithelial-mesenchymal transition predicts sensitivity to the dual IGF-1R/IR inhibitor OSI-906 in hepatocellular carcinoma cell lines.	IGF1R INSR	7.69e-07	2	31	2	22161861
Pubmed	IGF-I and insulin activate mitogen-activated protein kinase via the type 1 IGF receptor in mouse embryonic stem cells.	IGF1R INSR	7.69e-07	2	31	2	17641087
Pubmed	Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance.	IGF1R INSR	7.69e-07	2	31	2	17416680
Pubmed	Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling.	IGF1R INSR	7.69e-07	2	31	2	22692545
Pubmed	Deficiency in insulin-like growth factors signalling in mouse Leydig cells increase conversion of testosterone to estradiol because of feminization.	IGF1R INSR	7.69e-07	2	31	2	32975906
Pubmed	Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity.	IGF1R INSR	7.69e-07	2	31	2	29040448
Pubmed	Engineered ubiquitin ligase PTB-U-box targets insulin/insulin-like growth factor receptor for degradation and coordinately inhibits cancer malignancy.	IGF1R INSR	7.69e-07	2	31	2	24970814
Pubmed	Preclinical and first-in-human phase I studies of KW-2450, an oral tyrosine kinase inhibitor with insulin-like growth factor receptor-1/insulin receptor selectivity.	IGF1R INSR	7.69e-07	2	31	2	26850678
Pubmed	High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy.	IGF1R INSR	7.69e-07	2	31	2	21177763
Pubmed	Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin Receptor.	IGF1R INSR	7.69e-07	2	31	2	28096258
Pubmed	Expression and purification of functional insulin and insulin-like growth factor 1 holoreceptors from mammalian cells.	IGF1R INSR	7.69e-07	2	31	2	28830678
Pubmed	Insulin, insulin receptor and insulin-like growth factor-I receptor on the human ocular surface.	IGF1R INSR	7.69e-07	2	31	2	12613967
Pubmed	Changes in insulin and IGF-I receptor expression during differentiation of human preadipocytes.	IGF1R INSR	7.69e-07	2	31	2	18693051
Pubmed	Signalling through the insulin receptor and the insulin-like growth factor-I receptor.	IGF1R INSR	7.69e-07	2	31	2	7821728
Pubmed	Periovulatory insulin signaling is essential for ovulation, granulosa cell differentiation, and female fertility.	IGF1R INSR	2.31e-06	3	31	2	31908002
Pubmed	Insulin receptor-related receptor as an extracellular alkali sensor.	IGF1R INSR	2.31e-06	3	31	2	21641549
Pubmed	MAP3K4 promotes fetal and placental growth by controlling the receptor tyrosine kinases IGF1R/IR and Akt signaling pathway.	IGF1R INSR	2.31e-06	3	31	2	35921893
Pubmed	Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes.	IGF1R INSR	2.31e-06	3	31	2	38816743
Pubmed	The Insulin Receptor and Insulin like Growth Factor Receptor 5' UTRs Support Translation Initiation Independently of EIF4G1.	IGF1R INSR	2.31e-06	3	31	2	37724583
Pubmed	Divergent roles of growth factors in the GnRH regulation of puberty in mice.	IGF1R INSR	2.31e-06	3	31	2	20628204
Pubmed	MicroRNA 322 Aggravates Dexamethasone-Induced Muscle Atrophy by Targeting IGF1R and INSR.	IGF1R INSR	2.31e-06	3	31	2	32046161
Pubmed	Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant.	IGF1R INSR	2.31e-06	3	31	2	16831875
Pubmed	Insulin-like growth factor 1 receptor (IGF1R) signaling regulates osterix expression and cartilage matrix mineralization during endochondral ossification.	IGF1R INSR	2.31e-06	3	31	2	26475121
Pubmed	Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice.	IGF1R INSR	2.31e-06	3	31	2	25269484
Pubmed	Caveolin-1 increases glycolysis in pancreatic cancer cells and triggers cachectic states.	IGF1R INSR	2.31e-06	3	31	2	34320244
Pubmed	Insulin receptor-related (Irr) is expressed in pre-implantation embryos: a possible relationship to "growth factor Y" and sex determination.	IGF1R INSR	2.31e-06	3	31	2	21681845
Pubmed	Insulin regulates neurovascular coupling through astrocytes.	IGF1R INSR	2.31e-06	3	31	2	35858325
Pubmed	Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain.	IGF1R INSR	2.31e-06	3	31	2	27510031
Pubmed	Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription.	IGF1R INSR	2.31e-06	3	31	2	20360006
Pubmed	Biological effects of insulin and its analogs on cancer cells with different insulin family receptor expression.	IGF1R INSR	2.31e-06	3	31	2	24683100
Pubmed	mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR.	IGF1R INSR	2.31e-06	3	31	2	26584640
Pubmed	The insulin-like growth factor I receptor regulates glucose transport by astrocytes.	IGF1R INSR	2.31e-06	3	31	2	27462832
Pubmed	Up-regulation of INSR/IGF1R by C-myc promotes TSCC tumorigenesis and metastasis through the NF-κB pathway.	IGF1R INSR	2.31e-06	3	31	2	29518496
Pubmed	Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor.	IGF1R INSR	2.31e-06	3	31	2	9524259
Pubmed	Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor.	IGF1R INSR	2.31e-06	3	31	2	11071852
Pubmed	Site-directed mutagenesis and yeast two-hybrid studies of the insulin and insulin-like growth factor-1 receptors: the Src homology-2 domain-containing protein hGrb10 binds to the autophosphorylated tyrosine residues in the kinase domain of the insulin receptor.	IGF1R INSR	2.31e-06	3	31	2	9369444
Pubmed	Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure.	IGF1R INSR	2.31e-06	3	31	2	25643582
Pubmed	Insulin/IGF1 signaling regulates the mitochondrial biogenesis markers in steroidogenic cells of prepubertal testis, but not ovary.	IGF1R INSR	2.31e-06	3	31	2	30084987
Pubmed	Tumor necrosis factor-alpha (TNF-alpha) inhibits insulin-like growth factor-I (IGF-I) activities in human trophoblast cell cultures through IGF-I/insulin hybrid receptors.	IGF1R INSR	2.31e-06	3	31	2	20009360
Pubmed	Interaction of the molecular weight 85K regulatory subunit of the phosphatidylinositol 3-kinase with the insulin receptor and the insulin-like growth factor-1 (IGF- I) receptor: comparative study using the yeast two-hybrid system.	IGF1R INSR	2.31e-06	3	31	2	8603569
Pubmed	Dichotomy of decorin activity on the insulin-like growth factor-I system.	IGF1R INSR	2.31e-06	3	31	2	23351020
Cytoband	12p13.2	TAS2R43 TAS2R46	4.29e-04	45	31	2	12p13.2
GeneFamily	Taste 2 receptors	TAS2R43 TAS2R46	7.58e-04	39	19	2	1162
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	IGF1R INSR	7.97e-04	40	19	2	321
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	CD79A IGF1R INSR	7.68e-03	394	19	3	471
GeneFamily	Fibronectin type III domain containing	IGF1R INSR	1.21e-02	160	19	2	555
ToppCell	droplet-Lung-LUNG-1m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFXN5 IGF1R DCK STK17B	4.28e-06	158	31	4	30cceb73cf5e24b692da84d33342fd3b1ad5efe5
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFXN5 IGF1R DCK STK17B	4.28e-06	158	31	4	47793463640f98ee5f680a1ee5786b453355fd57
Drug	Insulin Glargine	IGF1R INSR	1.57e-06	2	29	2	ctd:D000069036
Drug	Insulin Lispro	IGF1R INSR	1.57e-06	2	29	2	DB00046
Drug	Insulin Glargine	IGF1R INSR	1.57e-06	2	29	2	DB00047
Drug	Mecasermin	IGF1R INSR	4.70e-06	3	29	2	DB01277
Drug	AC1L1GKK	IGF1R INSR	9.38e-06	4	29	2	CID000003725
Drug	PQ401	IGF1R INSR	1.56e-05	5	29	2	CID009549305
Drug	AC1L1CTI	IGF1R INSR	2.34e-05	6	29	2	CID000002057
Drug	pp175	IGF1R INSR	3.28e-05	7	29	2	CID000006543
Drug	monomethyl phthalate	DAO ITPKC IDI1 RNF103	4.30e-05	155	29	4	CID000020392
Drug	1,5-AG	COL18A1 IGF1R KIDINS220 INSR	8.02e-05	182	29	4	CID000064960
Drug	DB02841	COL18A1 KIDINS220 PLXNB3	8.81e-05	68	29	3	CID005288987
Drug	Insulin recombinant	IGF1R INSR	1.03e-04	12	29	2	DB00030
Drug	copper(II) sulfate pentahydrate; Up 200; 100uM; MCF7; HG-U133A	SETD1A IGF1R LLGL2 NRDC	1.09e-04	197	29	4	438_UP
Drug	Idazoxan hydrochloride [79944-56-2]; Up 200; 16.6uM; MCF7; HT_HG-U133A	SETD1A KIDINS220 STK17B INSR	1.11e-04	198	29	4	5347_UP
Drug	Insulin, porcine	IGF1R INSR	1.21e-04	13	29	2	DB00071
Disease	gestational diabetes (biomarker_via_orthology)	IGF1R INSR	8.67e-06	5	28	2	DOID:11714 (biomarker_via_orthology)
Disease	alcohol dependence (implicated_via_orthology)	IGF1R INSR	3.11e-05	9	28	2	DOID:0050741 (implicated_via_orthology)
Disease	sleep disorder (implicated_via_orthology)	IGF1R INSR	4.75e-05	11	28	2	DOID:535 (implicated_via_orthology)
Disease	chronic kidney disease (implicated_via_orthology)	SHROOM3 INSR	5.70e-05	12	28	2	DOID:784 (implicated_via_orthology)
Disease	diabetic neuropathy (implicated_via_orthology)	IGF1R INSR	7.85e-05	14	28	2	DOID:9743 (implicated_via_orthology)
Disease	Congenital hernia of foramen of Morgagni	IGF1R INSR	1.47e-04	19	28	2	C0265699
Disease	Congenital hernia of foramen of Bochdalek	IGF1R INSR	1.47e-04	19	28	2	C0265700
Disease	prostate adenocarcinoma (is_implicated_in)	IGF1R INSR	1.63e-04	20	28	2	DOID:2526 (is_implicated_in)
Disease	Congenital diaphragmatic hernia	IGF1R INSR	1.80e-04	21	28	2	C0235833
Disease	Lewy Body Disease	IGF1R INSR	1.98e-04	22	28	2	C0752347
Disease	uric acid measurement	SHROOM3 IGF1R SIMC1 SELENOO INSR	2.46e-04	610	28	5	EFO_0004761
Disease	diabetes mellitus (implicated_via_orthology)	IGF1R INSR	2.78e-04	26	28	2	DOID:9351 (implicated_via_orthology)
Disease	glucose metabolism disease (implicated_via_orthology)	IGF1R INSR	3.23e-04	28	28	2	DOID:4194 (implicated_via_orthology)
Disease	high grade glioma (implicated_via_orthology)	IGF1R INSR	8.01e-04	44	28	2	DOID:3070 (implicated_via_orthology)
Disease	hepatocellular carcinoma (implicated_via_orthology)	COL18A1 INSR	9.93e-04	49	28	2	DOID:684 (implicated_via_orthology)
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	SHROOM3 LLGL2 INSR	1.23e-03	224	28	3	EFO_0004530, EFO_0008317
Disease	Alzheimer's disease (biomarker_via_orthology)	IGF1R INSR	1.39e-03	58	28	2	DOID:10652 (biomarker_via_orthology)
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	IGF1R INSR	1.74e-03	65	28	2	DOID:0080208 (biomarker_via_orthology)
Disease	Lung diseases	IGF1R INSR	2.49e-03	78	28	2	C0024115
Disease	Parkinson Disease	IGF1R INSR	2.95e-03	85	28	2	C0030567
Disease	Acute Confusional Senile Dementia	IGF1R INSR	3.98e-03	99	28	2	C0546126
Disease	Presenile dementia	IGF1R INSR	3.98e-03	99	28	2	C0011265
Disease	Alzheimer's Disease, Focal Onset	IGF1R INSR	3.98e-03	99	28	2	C0750900
Disease	Alzheimer Disease, Early Onset	IGF1R INSR	3.98e-03	99	28	2	C0750901
Disease	Alzheimer Disease, Late Onset	IGF1R INSR	3.98e-03	99	28	2	C0494463
Disease	Familial Alzheimer Disease (FAD)	IGF1R INSR	4.06e-03	100	28	2	C0276496
Disease	Alzheimer's Disease	IGF1R INSR	4.14e-03	101	28	2	C0002395
Disease	type 2 diabetes mellitus (implicated_via_orthology)	IGF1R INSR	4.46e-03	105	28	2	DOID:9352 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
WAEGRWNNQSIDLNH	CPXM1	421	Q96SM3
HNSSNNANVTWWRVL	CD79A	56	P11912
RLWQTLQQFWADHIS	CBY3	71	A6NI87
WADNLWTHQNSSSLQ	ITPKC	191	Q96DU7
NWSELNNIQDHNTIW	DAO	246	P14920
NQISFNWDRLASWIN	KIDINS220	956	Q9ULH0
WQLDWDELETNQQHF	M1AP	336	Q8TC57
HFLSSQQLENIWWQR	LLGL2	226	Q6P1M3
QNLQQLWDWDHRNLT	IGF1R	426	P08069
TNHWWNELFNKTAAN	GPATCH4	61	Q5T3I0
QLNQWLWSYEEDSHC	PLXNB3	511	Q9ULL4
LNLNWLWFNNEDTSH	COL18A1	26	P39060
DNQNLRQLWDWSKHN	INSR	431	P06213
PWWQNESLAAFRNHT	EEF1AKMT4-ECE2	741	P0DPD8
SLWTWRHFLNWALQQ	CEMP1	131	Q6PRD7
FKWWDNLNHLNQFVD	IDI1	206	Q13907
QDWHDWMNNQFGQSL	DCK	156	P27707
EVNANNLEWLSSLWD	RNF103	446	O00237
NIWAVINHFSNWLAT	TAS2R43	86	P59537
NVWAVINHFSNWLAT	TAS2R46	86	P59540
SWLQQWDFENLFHPE	STK17B	291	O94768
ELQSRNQGHWADWLQ	SELENOO	546	Q9BVL4
SQWQTWDELVEHLQF	SIMC1	761	Q8NDZ2
WEGDFQEDHNANLWR	SHROOM3	626	Q8TF72
LQQTSGADWLNDTHW	SETD1A	1451	O15047
INQHWDWLEQNLLHT	TBC1D8	86	O95759
IENSWAELWNSNFEL	NRDC	636	O43847
YNNLLWSNWSVDALS	SRRD	226	Q9UH36
ASTVFWQWLNQSHNA	SFXN5	131	Q8TD22
WQWLNQSHNACVNYA	SFXN5	136	Q8TD22
SDSVNNLQWFHQNPW	TRAV22	46	A0A0B4J277
VSHNNLQSAWRWALN	VWA3A	566	A6NCI4