Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	channel activity	CLCA4 NOX5 GLRA3 KCNMA1 ANO7 PKDREJ AQP4 CALHM2 ITPR1	3.75e-05	525	63	9	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CLCA4 NOX5 GLRA3 KCNMA1 ANO7 PKDREJ AQP4 CALHM2 ITPR1	3.81e-05	526	63	9	GO:0022803
GeneOntologyMolecularFunction	monoatomic ion channel activity	CLCA4 NOX5 GLRA3 KCNMA1 ANO7 PKDREJ CALHM2 ITPR1	9.38e-05	459	63	8	GO:0005216
GeneOntologyMolecularFunction	collagen binding	ITGA11 COL14A1 MMP9 MMP12	1.25e-04	81	63	4	GO:0005518
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	CLCA4 GLRA3 KCNMA1 ANO7 ITPR1	3.57e-04	193	63	5	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	CLCA4 GLRA3 KCNMA1 ANO7 ITPR1	3.93e-04	197	63	5	GO:0022834
GeneOntologyMolecularFunction	ligand-gated monoatomic anion channel activity	CLCA4 GLRA3 ANO7	5.28e-04	50	63	3	GO:0099095
GeneOntologyMolecularFunction	metalloendopeptidase activity	CLCA4 ZMPSTE24 MMP9 MMP12	5.62e-04	120	63	4	GO:0004222
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC9B1 CLCA4 NOX5 GLRA3 KCNMA1 ANO7 PKDREJ AQP4 ITPR1	5.89e-04	758	63	9	GO:0015318
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC9B1 CLCA4 NOX5 GLRA3 KCNMA1 ANO7 PKDREJ CALHM2 ITPR1	8.12e-04	793	63	9	GO:0015075
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	UGT1A6 UGGT2 UGT3A2 COLGALT1	1.39e-03	153	63	4	GO:0008194
GeneOntologyMolecularFunction	phospholipid binding	MYO1G CPNE9 VNN1 DAPP1 SNX1 PICK1 ITPR1	1.65e-03	548	63	7	GO:0005543
GeneOntologyMolecularFunction	intracellularly calcium-gated channel activity	CLCA4 ANO7	1.79e-03	20	63	2	GO:0141147
GeneOntologyMolecularFunction	intracellularly calcium-gated chloride channel activity	CLCA4 ANO7	1.79e-03	20	63	2	GO:0005229
GeneOntologyCellularComponent	PAR polarity complex	PARD6A PARD6G	1.29e-04	6	62	2	GO:0120157
Domain	RNase_H1_N	RNASEH1 ANKLE2	1.08e-05	2	62	2	IPR011320
Domain	Cauli_VI	RNASEH1 ANKLE2	1.08e-05	2	62	2	PF01693
Domain	-	RNASEH1 ANKLE2	1.08e-05	2	62	2	3.40.970.10
Domain	VWF_A	SEC24D ITGA11 CLCA4 CPNE9 COL14A1	1.93e-05	99	62	5	IPR002035
Domain	VWFA	ITGA11 CLCA4 CPNE9 COL14A1	1.59e-04	82	62	4	PS50234
Domain	VWA	ITGA11 CLCA4 CPNE9 COL14A1	1.74e-04	84	62	4	SM00327
Domain	VWA	ITGA11 CLCA4 COL14A1	8.52e-04	56	62	3	PF00092
Domain	PB1	PARD6A PARD6G	9.62e-04	14	62	2	SM00666
Domain	PB1	PARD6A PARD6G	9.62e-04	14	62	2	PF00564
Domain	PB1	PARD6A PARD6G	9.62e-04	14	62	2	PS51745
Domain	PB1_dom	PARD6A PARD6G	9.62e-04	14	62	2	IPR000270
Domain	Pept_M10A_Zn_BS	MMP9 MMP12	1.11e-03	15	62	2	IPR021158
Domain	Hemopexin_CS	MMP9 MMP12	1.43e-03	17	62	2	IPR018486
Domain	-	SEC24D CLCA4 COL14A1	1.91e-03	74	62	3	3.40.50.410
Domain	PG_binding_1	MMP9 MMP12	1.98e-03	20	62	2	PF01471
Domain	Peptidoglycan-bd-like	MMP9 MMP12	1.98e-03	20	62	2	IPR002477
Domain	UDPGT	UGT1A6 UGT3A2	2.19e-03	21	62	2	PF00201
Domain	UDPGT	UGT1A6 UGT3A2	2.19e-03	21	62	2	PS00375
Domain	UDP_glucos_trans	UGT1A6 UGT3A2	2.19e-03	21	62	2	IPR002213
Domain	-	UGGT2 COLGALT1 UAP1L1	2.47e-03	81	62	3	3.90.550.10
Domain	Hemopexin-like_dom	MMP9 MMP12	2.62e-03	23	62	2	IPR000585
Domain	Hemopexin-like_repeat	MMP9 MMP12	2.62e-03	23	62	2	IPR018487
Domain	M10A_MMP	MMP9 MMP12	2.62e-03	23	62	2	IPR033739
Domain	Hemopexin	MMP9 MMP12	2.62e-03	23	62	2	PF00045
Domain	HEMOPEXIN	MMP9 MMP12	2.62e-03	23	62	2	PS00024
Domain	-	MMP9 MMP12	2.62e-03	23	62	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP9 MMP12	2.62e-03	23	62	2	PS51642
Domain	HX	MMP9 MMP12	2.62e-03	23	62	2	SM00120
Domain	Pept_M10A	MMP9 MMP12	2.62e-03	23	62	2	IPR021190
Domain	Peptidase_M10	MMP9 MMP12	2.85e-03	24	62	2	PF00413
Domain	Nucleotide-diphossugar_trans	UGGT2 COLGALT1 UAP1L1	3.13e-03	88	62	3	IPR029044
Domain	ZnMc	MMP9 MMP12	4.16e-03	29	62	2	SM00235
Domain	Peptidase_Metallo	MMP9 MMP12	4.16e-03	29	62	2	IPR006026
Domain	ZINC_PROTEASE	ZMPSTE24 MMP9 MMP12	4.23e-03	98	62	3	PS00142
Domain	Myosin_head_motor_dom	MYO1G MYH13	7.06e-03	38	62	2	IPR001609
Pubmed	Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling.	MMP9 MMP12	3.33e-06	2	64	2	12189240
Pubmed	Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells.	KCNMA1 ITPR1	3.33e-06	2	64	2	20713546
Pubmed	Roles of matrix metalloproteinases in flow-induced outward vascular remodeling.	MMP9 MMP12	3.33e-06	2	64	2	19513084
Pubmed	Novel blood biomarkers of pancreatic cancer-associated diabetes mellitus identified by peripheral blood-based gene expression profiles.	VNN1 MMP9	3.33e-06	2	64	2	20571492
Pubmed	Association between matrix metalloproteinase family gene polymorphisms and risk of ischemic stroke: A systematic review and meta-analysis of 29 studies.	MMP9 MMP12	3.33e-06	2	64	2	29906531
Pubmed	Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms.	MMP9 MMP12	3.33e-06	2	64	2	10841523
Pubmed	Loss of matrix metalloproteinase-9 or matrix metalloproteinase-12 protects apolipoprotein E-deficient mice against atherosclerotic media destruction but differentially affects plaque growth.	MMP9 MMP12	3.33e-06	2	64	2	14993123
Pubmed	Differential expression of MMP-9 and AQP4 in human glioma samples.	MMP9 AQP4	3.33e-06	2	64	2	22773464
Pubmed	Polymorphisms in matrix metalloproteinase-1, -9 and -12 genes and the risk of chronic obstructive pulmonary disease in a Korean population.	MMP9 MMP12	9.99e-06	3	64	2	20160424
Pubmed	β-Dystroglycan cleavage by matrix metalloproteinase-2/-9 disturbs aquaporin-4 polarization and influences brain edema in acute cerebral ischemia.	MMP9 AQP4	9.99e-06	3	64	2	27038751
Pubmed	Matrix metalloproteinase (MMP)-3 activates MMP-9 mediated vascular smooth muscle cell migration and neointima formation in mice.	MMP9 MMP12	9.99e-06	3	64	2	21719762
Pubmed	Gene polymorphisms of matrix metalloproteinase-2, -9 and -12 in periodontal health and severe chronic periodontitis.	MMP9 MMP12	9.99e-06	3	64	2	18155181
Pubmed	[Polymorphism in promoter regions of matrix metalloproteinases (MMP1, MMP9, and MMP12) in chronic obstructive pulmonary disease patients].	MMP9 MMP12	9.99e-06	3	64	2	18619044
Pubmed	Matrix metalloproteinase expression by human alveolar macrophages in relation to emphysema.	MMP9 MMP12	9.99e-06	3	64	2	18259971
Pubmed	MMP-1(-1607G) polymorphism as a risk factor for fibrosis after pulmonary tuberculosis in Taiwan.	MMP9 MMP12	9.99e-06	3	64	2	20392358
Pubmed	Matrix metalloproteinase gene polymorphisms: lack of association with chronic obstructive pulmonary disease in a Brazilian population.	MMP9 MMP12	9.99e-06	3	64	2	19731200
Pubmed	Matrix metalloproteinase-2, -9, and -12 gene polymorphisms in generalized aggressive periodontitis.	MMP9 MMP12	9.99e-06	3	64	2	18052707
Pubmed	Cutaneous MMPs are differently modulated by environmental stressors in old and young mice.	MMP9 MMP12	9.99e-06	3	64	2	17681721
Pubmed	[Study on matrix metalloproteinase 1, 9, 12 polymorphisms and susceptibility to chronic obstructive pulmonary disease among Han nationality in northern China].	MMP9 MMP12	9.99e-06	3	64	2	16676616
Pubmed	Regulation of elastolytic proteases in the mouse vagina during pregnancy, parturition, and puerperium.	MMP9 MMP12	9.99e-06	3	64	2	18003950
Pubmed	The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function.	MMP9 MMP12	9.99e-06	3	64	2	11875051
Pubmed	miR-211-5p targeting MMP9 regulates the expressions of AQP4 in traumatic brain injury.	MMP9 AQP4	9.99e-06	3	64	2	37020131
Pubmed	Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population.	MMP9 MMP12	9.99e-06	3	64	2	20078883
Pubmed	Polymorphisms in matrix metalloproteinase-1, -3, -9, and -12 genes in relation to subarachnoid hemorrhage.	MMP9 MMP12	2.00e-05	4	64	2	11546917
Pubmed	Extracellular matrix remodeling genes polymorphisms and risk of chronic bronchitis and recurrent pneumonia in children.	MMP9 MMP12	2.00e-05	4	64	2	23575435
Pubmed	Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy.	MMP9 MMP12	2.00e-05	4	64	2	11689884
Pubmed	[Expression of genes for metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-12) associated with psoriasis].	MMP9 MMP12	2.00e-05	4	64	2	22117411
Pubmed	Polymorphisms in the promoter regions of MMP-2, MMP-3, MMP-9 and MMP-12 genes as determinants of aneurysmal coronary artery disease.	MMP9 MMP12	2.00e-05	4	64	2	12103254
Pubmed	Differential Matrix Metalloprotease (MMP) Expression Profiles Found in Aged Gingiva.	MMP9 MMP12	2.00e-05	4	64	2	27391467
Pubmed	Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice.	MMP9 MMP12	2.00e-05	4	64	2	10801980
Pubmed	Surfactant protein-D regulates soluble CD14 through matrix metalloproteinase-12.	MMP9 MMP12	2.00e-05	4	64	2	15814723
Pubmed	Association of MMP1, MMP3, MMP9, and MMP12 polymorphisms with risk and clinical course of multiple sclerosis in a Polish population.	MMP9 MMP12	2.00e-05	4	64	2	19628284
Pubmed	Functional polymorphisms in matrix metalloproteinases -1, -3, -9 and -12 in relation to cervical artery dissection.	MMP9 MMP12	2.00e-05	4	64	2	19664242
Pubmed	MMP-9 and -12 cause N-cadherin shedding and thereby beta-catenin signalling and vascular smooth muscle cell proliferation.	MMP9 MMP12	2.00e-05	4	64	2	18852254
Pubmed	Activation of galanin receptor 2 stimulates large conductance Ca(2+)-dependent K(+) (BK) channels through the IP3 pathway in human embryonic kidney (HEK293) cells.	KCNMA1 ITPR1	2.00e-05	4	64	2	24602615
Pubmed	Alveolar macrophage proteinase/antiproteinase expression in lung function and emphysema.	MMP9 MMP12	2.00e-05	4	64	2	23900981
Pubmed	Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 and -12 null mice.	MMP9 MMP12	2.00e-05	4	64	2	16495447
Pubmed	Neither SP-A nor NH2-terminal domains of SP-A can substitute for SP-D in regulation of alveolar homeostasis.	MMP9 MMP12	3.32e-05	5	64	2	16500946
Pubmed	Genotype-phenotype relationships in an investigation of the role of proteases in abdominal aortic aneurysm expansion.	MMP9 MMP12	3.32e-05	5	64	2	16082623
Pubmed	Genetic analysis of MMP gene polymorphisms in patients with Kawasaki disease.	MMP9 MMP12	3.32e-05	5	64	2	18091353
Pubmed	Altered Expression Levels of MMP1, MMP9, MMP12, TIMP1, and IL-1β as a Risk Factor for the Elevated IOP and Optic Nerve Head Damage in the Primary Open-Angle Glaucoma Patients.	MMP9 MMP12	3.32e-05	5	64	2	26120586
Pubmed	Effect of TGF-beta1 on MMP/TIMP and TGF-beta1 receptors in great saphenous veins and its significance on chronic venous insufficiency.	MMP9 MMP12	3.32e-05	5	64	2	27329669
Pubmed	Association of genotypes at the matrix metalloproteinase (MMP) loci with carotid IMT and presence of carotid and femoral atherosclerotic plaques.	MMP9 MMP12	3.32e-05	5	64	2	24043512
Pubmed	Expression of metalloproteinases 1, 2, 7, 9, and 12 in human cytotrophoblastic cells from normal and preeclamptic placentas.	MMP9 MMP12	3.32e-05	5	64	2	22936257
Pubmed	Role of NADPH oxidase-2 in lipopolysaccharide-induced matrix metalloproteinase expression and cell migration.	MMP9 MMP12	3.32e-05	5	64	2	19935767
Pubmed	Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure.	MMP9 MMP12	4.98e-05	6	64	2	10502816
Pubmed	Matrix metalloproteinase single-nucleotide polymorphisms and haplotypes predict breast cancer progression.	MMP9 MMP12	4.98e-05	6	64	2	18006768
Pubmed	Arhgef1 regulates alpha5beta1 integrin-mediated matrix metalloproteinase expression and is required for homeostatic lung immunity.	MMP9 MMP12	4.98e-05	6	64	2	20093499
Pubmed	Tissue inhibitor of metalloproteinase 1 regulates resistance to infection.	MMP9 MMP12	4.98e-05	6	64	2	15618213
Pubmed	Matrix metalloproteinase polymorphisms and bladder cancer risk.	MMP9 MMP12	4.98e-05	6	64	2	17178858
Pubmed	Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation.	MMP9 MMP12	4.98e-05	6	64	2	9398846
Pubmed	Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex.	GRK2 CLTC	4.98e-05	6	64	2	12163475
Pubmed	Single nucleotide polymorphisms in matrix metalloproteinase genes and lung cancer chemotherapy response and prognosis.	MMP9 MMP12	4.98e-05	6	64	2	19643940
Pubmed	Putative functional polymorphisms of MMP9 predict survival of NSCLC in a Chinese population.	MMP9 MMP12	4.98e-05	6	64	2	19132754
Pubmed	Matrix metalloproteinase activity in pediatric acute lung injury.	MMP9 MMP12	4.98e-05	6	64	2	19159011
Pubmed	Contributions of matrix metalloproteinases toward Meckel's cartilage resorption in mice: immunohistochemical studies, including comparisons with developing endochondral bones.	MMP9 MMP12	4.98e-05	6	64	2	17136358
Pubmed	Matrix metalloproteinase polymorphisms are associated with bladder cancer invasiveness.	MMP9 MMP12	4.98e-05	6	64	2	17473191
Pubmed	Genes predisposing to rapid aneurysm growth.	MMP9 MMP12	4.98e-05	6	64	2	17182940
Pubmed	β-Arrestin1 and GPCR kinase2 play permissive roles in Src-mediated endocytosis of α4β2 nicotinic ACh receptors.	GRK2 CLTC	4.98e-05	6	64	2	33844281
Pubmed	Defining the membrane proteome of NK cells.	MYO1G FXR1 GRK2 ZMPSTE24 RBM19 CDS2 CLTC COLGALT1 ANKLE2 ITPR1	5.12e-05	1168	64	10	19946888
Pubmed	GRK2-mediated receptor phosphorylation and Mdm2-mediated β-arrestin2 ubiquitination drive clathrin-mediated endocytosis of G protein-coupled receptors.	GRK2 CLTC	6.96e-05	7	64	2	32962859
Pubmed	A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl.	PARD6A PARD6G	6.96e-05	7	64	2	12629547
Pubmed	PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions.	PARD6A PARD6G	6.96e-05	7	64	2	12459187
Pubmed	Matrix metalloproteinases cleave tissue factor pathway inhibitor. Effects on coagulation.	MMP9 MMP12	6.96e-05	7	64	2	10859319
Pubmed	Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation.	MMP9 MMP12	6.96e-05	7	64	2	11113146
Pubmed	Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation.	MMP9 MMP12	6.96e-05	7	64	2	28912710
Pubmed	Functional polymorphisms and haplotypes in the promoter of the MMP2 gene are associated with risk of nasopharyngeal carcinoma.	MMP9 MMP12	6.96e-05	7	64	2	17607721
Pubmed	The WD40 protein Morg1 facilitates Par6-aPKC binding to Crb3 for apical identity in epithelial cells.	PARD6A PARD6G	6.96e-05	7	64	2	23439680
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	FXR1 DIS3L CDS2 UTP20 UGGT2 COLGALT1 RNASEH1 NOL8	7.13e-05	754	64	8	33060197
Pubmed	Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells.	PARD6A PARD6G	9.27e-05	8	64	2	12203721
Pubmed	Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.	PARD6A PARD6G	9.27e-05	8	64	2	11260256
Pubmed	Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity.	PARD6A PARD6G	1.19e-04	9	64	2	18562307
Pubmed	Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures.	PARD6A PARD6G	1.19e-04	9	64	2	11257119
Pubmed	A generic approach for the purification of signaling complexes that specifically interact with the carboxyl-terminal domain of G protein-coupled receptors.	MYO1G GRK2 CLTC	1.46e-04	55	64	3	18448421
Pubmed	The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42.	PARD6A PARD6G	1.49e-04	10	64	2	10934474
Pubmed	Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis.	MMP9 MMP12	1.49e-04	10	64	2	20181883
Pubmed	Tcf20 deficiency is associated with increased liver fibrogenesis and alterations in mitochondrial metabolism in mice and humans.	MMP9 MMP12	1.81e-04	11	64	2	37312667
Pubmed	Collagen XIV is important for growth and structural integrity of the myocardium.	COL14A1 COLGALT1	2.17e-04	12	64	2	22906538
Pubmed	Differential expression of tissue inhibitor of metalloproteinases type 1 (TIMP-1) during mouse gonad development.	MMP9 MMP12	2.57e-04	13	64	2	12815621
Pubmed	Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms.	MMP9 MMP12	2.57e-04	13	64	2	15944607
Pubmed	A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells.	PARD6A PARD6G	2.57e-04	13	64	2	17057644
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	RBM19 CLTC UTP20 SSRP1 MMP9 NOL8	2.64e-04	483	64	6	36912080
Pubmed	The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage.	FXR1 CLTC SSRP1	2.98e-04	70	64	3	30559450
Pubmed	HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation.	CLCA4 KCNMA1	2.99e-04	14	64	2	10758170
Pubmed	Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation.	CLTC PICK1	2.99e-04	14	64	2	20802490
Pubmed	Metalloproteinases promote plaque rupture and myocardial infarction: A persuasive concept waiting for clinical translation.	MMP9 MMP12	2.99e-04	14	64	2	25636537
Pubmed	Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.	MMP9 MMP12	2.99e-04	14	64	2	16236725
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	ITGA11 ZMPSTE24 OAF FKTN UTP20 UGGT2 COLGALT1 SNX1 ITPR1	3.38e-04	1201	64	9	35696571
Pubmed	Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families.	MMP9 MMP12	3.93e-04	16	64	2	20484597
Pubmed	Matrix metalloproteinases in tumor invasion.	MMP9 MMP12	3.93e-04	16	64	2	10949577
Pubmed	Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor.	MMP9 MMP12	3.93e-04	16	64	2	37701782
Pubmed	Splicing factor Srsf5 deletion disrupts alternative splicing and causes noncompaction of ventricular myocardium.	MMP9 MMP12	4.45e-04	17	64	2	34622152
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	ZMPSTE24 RBM19 GPC4 UTP20 NOL8	4.64e-04	349	64	5	25665578
Pubmed	Pericytes are required for blood-brain barrier integrity during embryogenesis.	MMP9 AQP4	5.59e-04	19	64	2	20944625
Pubmed	ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.	MMP9 MMP12	5.59e-04	19	64	2	22014525
Pubmed	Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes.	MYO1G CLTC	6.84e-04	21	64	2	12202484
Pubmed	Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate.	UGGT2 COLGALT1	6.84e-04	21	64	2	23097496
Pubmed	Functional interactions between matrix metalloproteinases and glycosaminoglycans.	MMP9 MMP12	7.52e-04	22	64	2	23421805
Pubmed	The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin.	PARD6A PARD6G	7.52e-04	22	64	2	27521426
Pubmed	Matrix metalloproteinases.	MMP9 MMP12	7.52e-04	22	64	2	10419448
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP9 MMP12	1.54e-03	24	44	2	891
GeneFamily	UDP glucuronosyltransferases	UGT1A6 UGT3A2	2.74e-03	32	44	2	363
GeneFamily	PDZ domain containing	PARD6A PARD6G PICK1	6.00e-03	152	44	3	1220
ToppCell	Entopeduncular-Macroglia-ASTROCYTE\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ITGA11 PPIL6 DAPP1 EFHB AQP4	1.19e-06	129	64	5	c37bdd6c0b2944fbfa064922954ea0e263160e2a
ToppCell	Entopeduncular-Macroglia-ASTROCYTE-Gja1\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ITGA11 PPIL6 DAPP1 EFHB AQP4	1.19e-06	129	64	5	8648ae59f7aca0f5b4983bdb4a65b03b2ca761e1
ToppCell	facs-Liver-Hepatocytes-3m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OAF VNN1 DIO1 SERPINA10 UGT3A2	1.72e-06	139	64	5	82bf5ba69a907fbd9b4e2b2dd1dd27b8c4c75f25
ToppCell	facs-Liver-Hepatocytes-3m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OAF VNN1 DIO1 SERPINA10 UGT3A2	1.72e-06	139	64	5	fc9ac09c2106e88104a52575832d71d17765eec8
ToppCell	facs-Liver-Hepatocytes-3m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OAF VNN1 DIO1 SERPINA10 UGT3A2	1.72e-06	139	64	5	fc4b39ac9a10cf0acacfebbc4295edf324d930d5
ToppCell	facs-Liver-Hepatocytes-3m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OAF VNN1 DIO1 SERPINA10 UGT3A2	1.72e-06	139	64	5	4ddfbc36a0560fb70594627178bff652ab1ea3e9
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITGA11 LGI2 KCNMA1 CALHM2 ITPR1	7.16e-06	186	64	5	4780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LGI2 GPC4 KCNMA1 CALHM2 ITPR1	8.14e-06	191	64	5	7853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	SEC24D ITGA11 MYH13 UGGT2 ITPR1	8.35e-06	192	64	5	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEC24D GRK2 KCNMA1 ANO7 ITPR1	8.56e-06	193	64	5	4aee372ba2c0351b0221d0d468707d1ad21526d6
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-secretory_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEC24D GRK2 KCNMA1 ANO7 ITPR1	8.56e-06	193	64	5	aaa5042388dc451bff384c6bb237348f08280a08
ToppCell	distal-Hematologic-Platelet/Megakaryocyte-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DNAH12 PPIL6 DIO1 MMP12 PKDREJ	9.46e-06	197	64	5	751ffb8792058384079ebfe94872b3525f1aea84
ToppCell	367C-Fibroblasts-Fibroblast-D-\|367C / Donor, Lineage, Cell class and subclass (all cells)	OAF KLHDC8A COL14A1 UGT3A2	7.15e-05	154	64	4	dd3d34f065820e706515a13619f19a5b12734c8e
ToppCell	367C-Fibroblasts-Fibroblast-D\|367C / Donor, Lineage, Cell class and subclass (all cells)	OAF KLHDC8A COL14A1 UGT3A2	7.15e-05	154	64	4	4bfda1c41efbb86d829b3797d1168bf2587c3c97
ToppCell	COPD-Myeloid-DC_Langerhans\|COPD / Disease state, Lineage and Cell class	DAPP1 SERPINA10 MMP9 MMP12	7.89e-05	158	64	4	71af1319eec34bf7bc9361ec9ef720c280ce97d1
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SLC9B1 MYH13 GLRA3	9.78e-05	62	64	3	a20620a8869721ea62984c2022ee1b484b455824
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SLC9B1 MYH13 GLRA3	9.78e-05	62	64	3	ee694c06bcd924b4ddf744178ba3a99e04eed51b
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPC4 DIO1 UGT3A2 AQP4	9.78e-05	167	64	4	40d102e01ccbc7262d00fafd59ca5234909009cb
ToppCell	droplet-Kidney-nan-3m-Epithelial-brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPC4 DIO1 UGT3A2 AQP4	1.05e-04	170	64	4	dd48fd3c5c67eb71183981f42975a538f12077c3
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITGA11 LGI2 COL14A1 CALHM2	1.07e-04	171	64	4	4ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCell	facs-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPC4 DIO1 UGT3A2 AQP4	1.17e-04	175	64	4	076ad81d6cbeea5512393d192af3ab5aa1f82975
ToppCell	facs-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPC4 DIO1 UGT3A2 AQP4	1.17e-04	175	64	4	445ccb9744a3a9ff37164c532afbe769d306b6c8
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TDRD5 TRANK1 SERPINA10 AQP4	1.31e-04	180	64	4	6327c938a4f99df9fee714e44f15ea4a4a63ae15
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-Macrophages\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNMA1 COLGALT1 MMP9 MMP12	1.36e-04	182	64	4	ea39b1b5db185b0cb11dfa2e01f3f972effbd770
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	LGI2 KCNMA1 COL14A1 ITPR1	1.39e-04	183	64	4	818fd886e0188091310825f9145fa53328f2c979
ToppCell	RA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	LGI2 KCNMA1 COL14A1 ITPR1	1.39e-04	183	64	4	cae2ee08f985a6f005b4b8e959e465350315156a
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SEC24D ITGA11 OAF COL14A1	1.45e-04	185	64	4	1b990e3089772be2b38c6d7ea0d1bf22461ae3ea
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ITGA11 LGI2 COL14A1 MMP9	1.45e-04	185	64	4	87c416d14ca6255bee39b16e7571553e36ee3069
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITGA11 LGI2 KCNMA1 CALHM2	1.48e-04	186	64	4	a95744b8649096bd7cfc3591a02841fa411085b3
ToppCell	facs-Trachea-nan-24m-Mesenchymal\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA11 OAF LGI2 COL14A1	1.51e-04	187	64	4	71385068e3fd0bfa7822ae176113a49460c8636b
ToppCell	droplet-Marrow-BM-1m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G COLGALT1 SNX1 CALHM2	1.51e-04	187	64	4	028e7d6e1211e123879d2f353dc32fae1185dd8e
ToppCell	facs-Trachea-nan-24m-Mesenchymal-fibroblast\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA11 OAF LGI2 COL14A1	1.51e-04	187	64	4	b930d5f7d410ac1f340babec5c937388f64cafc0
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SAMD9 CAB39L ANKLE2 UAP1L1	1.51e-04	187	64	4	a6a112689d1c9049f57935ad9d2f4955538427de
ToppCell	facs-Trachea-nan-24m-Mesenchymal-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA11 OAF LGI2 COL14A1	1.51e-04	187	64	4	e891e571f6bb9433a0046215de6cabd89ed1effc
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CPNE9 DNAH12 PKDREJ	1.53e-04	72	64	3	7877184d5c9dd6d96476d71e7504e58c0b4d0f26
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LGI2 KCNMA1 HCRTR2 CALHM2	1.57e-04	189	64	4	975e7aa3b862a8b07c2ab8426a14f5cc54998aca
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 KCNMA1 COL14A1 ITPR1	1.57e-04	189	64	4	c734e5693808a0333139e87bd5be2597a9252afe
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 KCNMA1 COL14A1 ITPR1	1.64e-04	191	64	4	c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 KCNMA1 COL14A1 ITPR1	1.64e-04	191	64	4	806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 KCNMA1 COL14A1 ITPR1	1.64e-04	191	64	4	cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA11 OAF LGI2 COL14A1	1.67e-04	192	64	4	beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEC24D KLHDC8A KCNMA1 ANO7	1.71e-04	193	64	4	6a9bce5064938b5b84ad57b4fd4a7841afe100c8
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Mesenchymal-mesenchymal_stem_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA11 OAF LGI2 COL14A1	1.71e-04	193	64	4	160691b671710be10220803d788c2c961c236af1
ToppCell	facs-Trachea-nan-3m-Epithelial\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLCA4 KLHDC8A DIO1 AQP4	1.74e-04	194	64	4	3701ca87c6dc9ccd7b4146e56371546174d26c36
ToppCell	facs-Trachea-nan-3m-Epithelial-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLCA4 KLHDC8A DIO1 AQP4	1.74e-04	194	64	4	65f9bf126be26114c2c3f4c46d48318986212a92
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEC24D KCNMA1 ANO7 ITPR1	1.74e-04	194	64	4	0797245ebfa389a6f66874cb0f11297f1456e600
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteoblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ITGA11 GPC4 KCNMA1 PARD6G	1.74e-04	194	64	4	292ce9021678534c9eedb367b9772a9d976208a8
ToppCell	P15-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	OAF GPC4 KCNMA1 COL14A1	1.74e-04	194	64	4	5f04d21c4e2d36e74b6c5889aa97fd98f75a0973
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-secretory_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEC24D KCNMA1 ANO7 ITPR1	1.74e-04	194	64	4	0241b4b88d6210b4c1b8aa99db17115b18142f01
ToppCell	distal-Hematologic-Platelet/Megakaryocyte\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DNAH12 PPIL6 DIO1 PKDREJ	1.84e-04	197	64	4	e28b1b154d9588dce07c123b36f7f01fa90a5fc1
ToppCell	Parenchymal-10x3prime_v2-Stromal-Fibroblastic-Fibro_immune_recruiting\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ITGA11 LGI2 COL14A1 CAB39L	1.84e-04	197	64	4	31c8d6e565bbdc37843ce871fe91845b0cc18a9f
ToppCell	Monocytes-NUPR1+_Monocytes\|Monocytes / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	ZMPSTE24 LGI2 KCNMA1 CALHM2	1.84e-04	197	64	4	8a058c9d9285acd7cf2fb8e34f7602a86b5d6c89
ToppCell	distal-3-Hematologic-Interstitial_Macrophage\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	VNN1 KCNMA1 MMP9 MMP12	1.88e-04	198	64	4	137a786da9f54b4f17e385a675d50a37de88f1b5
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ITGA11 OAF COL14A1 CCDC63	1.92e-04	199	64	4	dfc5c7a4a093baa7158dd8d4d29a870d9c469a3f
ToppCell	distal-mesenchymal-Adventitial_Fibroblast-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ITGA11 OAF COL14A1 SERPINA10	1.92e-04	199	64	4	6e8a44e46b46e87b81dbfc56fcbbcde166fd00fe
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ITGA11 OAF COL14A1 CCDC63	1.92e-04	199	64	4	c1760581c34b81d1d92c67500a1c8944e9cc6dad
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	GPC4 KCNMA1 CALHM2 ITPR1	1.95e-04	200	64	4	f599e4b051ac3dad11ad437e98dc8ea6754cca53
ToppCell	distal-3-Hematologic-Platelet/Megakaryocyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DNAH12 PPIL6 DIO1 PKDREJ	1.95e-04	200	64	4	f5f5a8b0e4d802d95dc42646dd5e7d7daaad72b4
ToppCell	LPS_IL1RA-Mesenchymal_myocytic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	GPC4 KCNMA1 CALHM2 ITPR1	1.95e-04	200	64	4	77631c471cc5d453a749784f838cfa6408caf09b
Drug	AC1OAGKW	GRK2 NOX5 CDS2 CLTC DAPP1 KCNMA1 SNX1 ITPR1	5.99e-08	193	63	8	CID006857413
Drug	Cysteamine	VNN1 MMP9 MMP12	7.19e-06	14	63	3	ctd:D003543
Disease	crescentic glomerulonephritis (biomarker_via_orthology)	MMP9 MMP12	1.17e-04	8	61	2	DOID:13139 (biomarker_via_orthology)
Disease	bacterial pneumonia (is_marker_for)	GRK2 MMP9	1.50e-04	9	61	2	DOID:874 (is_marker_for)
Disease	Centriacinar Emphysema	MMP9 MMP12	2.74e-04	12	61	2	C0221227
Disease	Panacinar Emphysema	MMP9 MMP12	2.74e-04	12	61	2	C0264393
Disease	Focal Emphysema	MMP9 MMP12	2.74e-04	12	61	2	C2350878
Disease	thoracic aortic aneurysm (is_marker_for)	MMP9 MMP12	3.76e-04	14	61	2	DOID:14004 (is_marker_for)
Disease	brain edema (biomarker_via_orthology)	MMP9 AQP4	4.34e-04	15	61	2	DOID:4724 (biomarker_via_orthology)
Disease	Huntington's disease (biomarker_via_orthology)	MMP9 ITPR1	4.95e-04	16	61	2	DOID:12858 (biomarker_via_orthology)
Disease	Alpha ketoglutarate measurement	SAMD9 GLRA3	4.95e-04	16	61	2	EFO_0010457
Disease	Pulmonary Emphysema	MMP9 MMP12	5.60e-04	17	61	2	C0034067
Disease	hyperglycemia (biomarker_via_orthology)	MMP9 HCRTR2	8.61e-04	21	61	2	DOID:4195 (biomarker_via_orthology)
Disease	Uterine leiomyoma	ITGA11 KCNMA1 ITPR1	8.97e-04	91	61	3	HP_0000131
Disease	primary biliary cholangitis (biomarker_via_orthology)	MMP9 AQP4	1.53e-03	28	61	2	DOID:12236 (biomarker_via_orthology)
Disease	arteriosclerosis (is_implicated_in)	MMP9 MMP12	1.88e-03	31	61	2	DOID:2349 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SDFEKAFAKRFGRSF	TDRD5	151	Q8NAT2
AKIILFSNQFRDFFK	CAB39L	156	Q9H9S4
VEFKRRFKEAFSKAA	AQP4	256	P55087
RFKAFSTREDAEKFA	ANKLE2	236	Q86XL3
FASGFKRAFKIKDFA	CDS2	356	O95674
FRPDFKRKFADFFED	ABHD4	221	Q8TB40
VFQKFIESDKFTRFC	GRK2	161	P25098
FRKFGFIGFKSEEEA	RBM19	41	Q9Y4C8
FGFVDFLTKQDAKRA	RBM19	876	Q9Y4C8
NKTEAFALEKFYRFS	GLRA3	356	O75311
VTTVGNKIFFFKDRF	MMP12	291	P39900
KAALHVKESFFAERF	NOX5	51	Q96PH1
VKESFFAERFFALFD	NOX5	56	Q96PH1
TKFEDAFTLKVFIFQ	ANO7	581	Q6IWH7
DRSDFFTSFYAKLKL	PAPOLB	126	Q9NRJ5
FEERLSKKLFFFSGR	MMP9	571	P14780
FFIASDAKEVKRAFF	KCNMA1	661	Q12791
FFCRLTEDKKSEKFF	ITPR1	1851	Q14643
AVFASRYKKFDEFFK	GPC4	96	O75487
AVKKARGFLEFVEDF	FXR1	271	P51114
AENFRFLSLFFKSKD	CALHM2	6	Q9HA72
EEFSREIFKTLKFFQ	DNAH12	721	Q6ZR08
RAKAKVAFRLDFEFS	ITGA11	901	Q9UKX5
LEKETTRFFFFSKND	NOL8	1106	Q76FK4
FSAKFLRDTKHDFVF	PPIL6	131	Q8IXY8
VKSKFGAEFRRFSLD	PARD6G	21	Q9BYG4
VEVKSKFDAEFRRFA	PARD6A	16	Q9NPB6
RFSTDYEFLDKFKQV	METTL21C	226	Q5VZV1
FKFDQFKRLIEDFSS	DIO1	131	P49895
FLSGKFREEFKAAFS	HCRTR2	366	O43614
FLAKEEKNFARFTYV	CCDC63	326	Q8NA47
ARHVFFVDDFDAFKK	COL14A1	1186	Q05707
FFSELRECAKAKGFF	DIS3L	716	Q8TF46
DFVRKFVLDYFFEEK	CPNE9	66	Q8IYJ1
FNEFSSLKDFVKHFA	DAPP1	96	Q9UN19
SFQGKDDVKLDVFFF	FKTN	356	O75072
TIFARKGVFERDFFK	EFHB	756	Q8N7U6
SFFLKKRRADFVAGS	KLHDC8A	261	Q8IYD2
SLVFEDDLRFEIFFK	COLGALT1	431	Q8NBJ5
SRRFEFQADAFAKKL	ZMPSTE24	411	O75844
FEAFKNELEAFKSRV	CDC37L1	256	Q7L3B6
KTFTAAGIKLIFFFD	FAM120B	76	Q96EK7
KIFESRFEKRLIFSF	UTP20	391	O75691
RDFFFASSFKGKTKI	LGI2	521	Q8N0V4
KVDFRAFKADFKTLA	SAMD9	356	Q5K651
SIKAFAFRHFLEAEF	PKDREJ	521	Q9NTG1
FTADFKKDVKVFRAL	OAF	71	Q86UD1
ETDALINFFAKSAFK	SEC24D	781	O94855
GFRESEFEKLSDFFK	SSRP1	76	Q08945
SNELFEEAFAIFRKF	CLTC	1061	Q00610
TYLFEATEKRFFFKN	CLCA4	61	Q14CN2
DRFPAARFKKFATED	RNASEH1	51	O60930
KEFKGTVFFDEFTFV	VNN1	331	O95497
FRSKQFAVKRRFSDF	SNX1	176	Q13596
FDVFRFAKNFAALEV	UAP1L1	386	Q3KQV9
DREQFRFGNTKVFFK	MYH13	756	Q9UKX3
CFAGFSFKEKIFIAL	SLC9B1	421	Q4ZJI4
AFIHKDFDVKETFFN	SERPINA10	166	Q9UK55
DFDVKETFFNLSKRY	SERPINA10	171	Q9UK55
GFEAEFIKSKFSFNL	TRAV8-1	81	A0A0A6YYK1
FFFLDSQDKSAVIAK	UGGT2	711	Q9NYU1
LNFFKESKFDALFTD	UGT1A6	136	P19224
QREFKKSFDFFLEET	UGT3A2	86	Q3SY77
LRDFQKLRDAFFKFD	TRANK1	1996	O15050
AFVKFADAHRSIEKF	PICK1	206	Q9NRD5
KAFEVEQDFKFFKSL	WDR64	971	B1ANS9
FIDKNRDFLFQDFKR	MYO1G	531	B0I1T2