Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
PathwayREACTOME_RELEASE_OF_HH_NP_FROM_THE_SECRETING_CELL

GPC5 NOTUM

7.38e-057272MM15187
PathwayREACTOME_RELEASE_OF_HH_NP_FROM_THE_SECRETING_CELL

GPC5 NOTUM

9.82e-058272M27444
Pubmed

Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1.

SETD2 POLR2A

1.29e-06240216314571
Pubmed

Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase.

SETD2 POLR2A

3.87e-06340216118227
Pubmed

The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation.

SETD2 POLR2A

7.73e-06440219141475
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

CDCA2 DDX56 SETD2 NCLN BCLAF1 POLR2A ANAPC2 MYBL2 BRMS1

1.28e-05129440930804502
Pubmed

De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair.

POLR2A RSF1

7.05e-051140231045206
Pubmed

Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.

VAV3 GPC5 PDE4D

1.30e-048540323648065
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

CDCA2 DDX56 SETD2 BCLAF1 POLR2A

1.45e-0444040534244565
Pubmed

SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.

CDK5RAP1 DDX56 DSG1 BCLAF1

1.80e-0424540435652658
Pubmed

An integrated genetic map of the pearl locus of mouse chromosome 13.

HEXB PDE4D

2.18e-04194028828042
Pubmed

PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier.

CYP4F22 DSG1

2.18e-041940228369476
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

STOX2 GPC5 PDE4D BCLAF1 POLR2A ANAPC2 MYBL2

3.12e-04115540720360068
Pubmed

Tissue-Specific Gain of RTK Signalling Uncovers Selective Cell Vulnerability during Embryogenesis.

GPC5 NOTUM

3.80e-042540226393505
Pubmed

ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress.

SETD2 POLR2A

4.12e-042640234162889
Pubmed

Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.

SETD2 POLR2A

4.78e-042840224462114
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

CDCA2 SETD2 BCLAF1 POLR2A MYBL2 RSF1

7.26e-0495440636373674
Pubmed

Impact of lactobacilli on orally acquired listeriosis.

STOX2 ANG CA3

8.64e-0416240323012479
Pubmed

The Vertebrate Genome Annotation browser 10 years on.

CDCA2 STOX2 ECEL1

8.79e-0416340324316575
Pubmed

A bead-based approach for large-scale identification of in vitro kinase substrates.

BIRC6 BCLAF1 RSF1

8.79e-0416340322113938
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

PLEKHJ1 DDX56 SETD2 GPSM1 BCLAF1 POLR2A

1.12e-03103840626673895
Cytoband5q13

HEXB PMCHL2

1.69e-04224025q13
Cytoband17q25.3

LRRC45 NOTUM

3.54e-0310140217q25.3
Cytoband9q34.3

GPSM1 ANAPC2

3.89e-031064029q34.3
CytobandEnsembl 112 genes in cytogenetic band chr19p13

PLEKHJ1 CYP4F22 LPAR2 NCLN

5.02e-03797404chr19p13
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SETD2 BIRC6 DOCK8 BCLAF1 RSF1

6.35e-071844051154a5ad7b8512272b7476f949ddac350910bfb7
ToppCelldroplet-Kidney-KIDNEY-1m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP12 SPATA6 GPSM1 DOCK8

1.65e-05171404d9ad6a3bce3556abd24af1630bf4a99594437c3a
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

STOX2 GPC5 PDE4D CCDC141

2.16e-051834046847c1252d6bb105524f812658112517fd351eab
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

STOX2 GPC5 PDE4D CCDC141

2.21e-05184404369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCellEpithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|World / Lineage, Cell type, age group and donor

STOX2 GPC5 PDE4D CA3

2.35e-0518740481cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCellControl-Epithelial_cells|Control / group, cell type (main and fine annotations)

STOX2 GPC5 PDE4D CCDC141

2.40e-05188404707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

STOX2 VAV3 GPC5 PDE4D

2.45e-05189404830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCellChildren_(3_yrs)-Epithelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

STOX2 GPC5 PDE4D CCDC141

2.55e-05191404e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCellCOVID-19-lung-AT2|lung / Disease (COVID-19 only), tissue and cell type

STOX2 GPC5 PDE4D CCDC141

2.55e-05191404276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

STOX2 GPC5 PDE4D DENND2B

2.60e-05192404efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

STOX2 GPC5 PDE4D CCDC141

2.60e-05192404fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCellcontrol-Myeloid-Immature_Neutrophils_2|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

CDCA2 STOX2 PDE4D MYBL2

2.66e-0519340433349830e9eba506470ad3661fad5e5a283d20ca
ToppCellnucseq-Epithelial-Epithelial_Alveolar|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

STOX2 GPC5 PDE4D CCDC141

2.71e-0519440453f3e49e91b1096f3226010e2de767efb490dfe4
ToppCellIPF-Endothelial-Lymphatic|Endothelial / Disease state, Lineage and Cell class

STOX2 VAV3 CCDC141 DOCK8

2.77e-05195404de88e9d22044b4b3e29676ad02b3e9299cc920ad
ToppCellcontrol-Myeloid-Immature_Neutrophils_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

CDCA2 STOX2 PDE4D MYBL2

2.77e-05195404bfaceb0601cf3855f38d6e1f482f01ad03ef11fe
ToppCellControl-Endothelial-Lymphatic|Endothelial / Disease state, Lineage and Cell class

STOX2 VAV3 CCDC141 DOCK8

2.82e-05196404e0cf617b0f5d9c3c19574f587a3d0ccbf93d8ca4
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HEXB DCLK3 CDCA2 MYBL2

2.88e-05197404954d4deaeba50c5b3faf52105c4cde961a682be1
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SETD2 BIRC6 DOCK8 BCLAF1

3.05e-0520040412f1685ce8f218433068e090c9d839cd5a1910bf
Diseasemigraine disorder, endometriosis

CDCA2 LRP12 POLR2A

1.25e-0473393EFO_0001065, MONDO_0005277
Diseasedifferentiated thyroid carcinoma

STOX2 VAV3

9.85e-0435392EFO_1002017
DiseaseFacial wrinkling

VAV3 CA3

1.10e-0337392HP_0009762
Diseaseobsolete_red blood cell distribution width

HSCB CDCA2 GPSM1 BIRC6 DOCK8 DENND2B MYBL2

1.73e-031347397EFO_0005192
Diseasemean platelet volume

HSCB SETD2 DOCK8 DENND2B POLR2A RSF1

2.07e-031020396EFO_0004584
Diseasebreast size

HSCB GPC5

3.78e-0369392EFO_0004884

Protein segments in the cluster

PeptideGeneStartEntry
CRVVFDDTYDRSMLR

CA3

66

P07451
ERMEDRCRGEYERSF

ANAPC2

271

Q9UJX6
RSVDRSLMYSEANRR

BIRC6

276

Q9NR09
SRQRLETEMQSYRCR

ANKRD36B

1031

Q8N2N9
RRMSRTFSECSYPET

DENND2B

226

P78524
SRRCVLMRLLDFSYE

NCLN

81

Q969V3
CKLYSLRMFERRSFE

LRP12

516

Q9Y561
VYSCRDAEMRRTFRR

LPAR2

291

Q9HBW0
RMRDRYDAFCFTSAL

HAPLN2

231

Q9GZV7
SSLEYSECIRMARRD

GPC5

186

P78333
AARRLYSRMEASCLE

GPSM1

16

Q86YR5
FRYRCRDAMRSVTKQ

DDX56

426

Q9NY93
MYDVEKLVRTRSCRR

DCLK3

171

Q9C098
DTERYLYCRAMDRTS

PDE4D

111

Q08499
RCSMESYRENLERVF

PCED1A

151

Q9H1Q7
MEEFRRSYSRLCRES

LRRC45

1

Q96CN5
DDRYCESIMRRRGLT

ANG

46

P03950
EYSGTLRRNSMRECR

DSG1

671

Q02413
RAFFRSCLDMREIER

ECEL1

181

O95672
FSRYESTRSGRRMEL

GBA

76

P04062
FNRENCDSRYDTMRR

NOTUM

131

Q6P988
CDSRYDTMRRLMSSR

NOTUM

136

Q6P988
RTLSRSVEYCAMRDE

CCDC141

891

Q6ZP82
MDKRDSFRRTRFSDR

DOCK8

1001

Q8NF50
SRSRDRMYSRDYRRD

BCLAF1

46

Q9NYF8
RRDFDTLRCMLGRVY

PMCHL2

66

Q9BQD1
DRKDRRRSMCYSDGR

CDCA2

826

Q69YH5
DMDDAYDRLTRHRCR

HEXB

521

P07686
RSTRTRKCISYRFDE

RSF1

1011

Q96T23
YRSADGRRFRQACDM

CYP4F22

256

Q6NT55
RDYFSLMDCNRSFRV

HSCB

71

Q8IWL3
MSRRTRCEDLDELHY

MYBL2

1

P10244
EALRRASYEFMRRSL

PLEKHJ1

101

Q9NW61
SRRFRDYCSQMLSKE

SECISBP2

626

Q96T21
EDYERRRSECVSEML

BRMS1

51

Q9HCU9
SSRVLEAMRRGYSRE

CDK5RAP1

406

Q96SZ6
RASDRMRSRSEKDYR

STOX2

21

Q9P2F5
RSTLCSRRMAEEFRL

POLR2A

1046

P24928
MSEEQLSRYEVCRRS

nan

101

A6NLC8
DTRYVSSRCRSERER

SETD2

386

Q9BYW2
YTKRRMCELSEDTRR

SPATA6

221

Q9NWH7
CFRKMEESSLETRRY

ZMAT1

241

Q5H9K5
RYDFCARDMRELSLL

VAV3

796

Q9UKW4