Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	oxalate transmembrane transporter activity	SLC26A7 SLC26A1	1.57e-04	10	38	2	GO:0019531
GeneOntologyMolecularFunction	sulfate transmembrane transporter activity	SLC26A7 SLC26A1	4.16e-04	16	38	2	GO:0015116
GeneOntologyMolecularFunction	protein binding involved in heterotypic cell-cell adhesion	GLDN NRCAM	5.29e-04	18	38	2	GO:0086080
Domain	SLC26A	SLC26A7 SLC26A1	1.80e-04	10	38	2	PS01130
Domain	STAS	SLC26A7 SLC26A1	2.19e-04	11	38	2	PS50801
Domain	SLC26A/SulP_fam	SLC26A7 SLC26A1	2.19e-04	11	38	2	IPR001902
Domain	STAS_dom	SLC26A7 SLC26A1	2.19e-04	11	38	2	IPR002645
Domain	-	SLC26A7 SLC26A1	2.19e-04	11	38	2	3.30.750.24
Domain	SLC26A/SulP_dom	SLC26A7 SLC26A1	2.19e-04	11	38	2	IPR011547
Domain	Sulfate_transp	SLC26A7 SLC26A1	2.19e-04	11	38	2	PF00916
Domain	STAS	SLC26A7 SLC26A1	2.19e-04	11	38	2	PF01740
Domain	Pept_M10A_stromelysin-type	MMP21 MMP15	6.04e-04	18	38	2	IPR016293
Domain	PG_binding_1	MMP21 MMP15	7.48e-04	20	38	2	PF01471
Domain	Peptidoglycan-bd-like	MMP21 MMP15	7.48e-04	20	38	2	IPR002477
Domain	Hemopexin-like_dom	MMP21 MMP15	9.93e-04	23	38	2	IPR000585
Domain	Hemopexin	MMP21 MMP15	9.93e-04	23	38	2	PF00045
Domain	HEMOPEXIN	MMP21 MMP15	9.93e-04	23	38	2	PS00024
Domain	-	MMP21 MMP15	9.93e-04	23	38	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP21 MMP15	9.93e-04	23	38	2	PS51642
Domain	Hemopexin-like_repeat	MMP21 MMP15	9.93e-04	23	38	2	IPR018487
Domain	HX	MMP21 MMP15	9.93e-04	23	38	2	SM00120
Domain	Pept_M10A	MMP21 MMP15	9.93e-04	23	38	2	IPR021190
Domain	M10A_MMP	MMP21 MMP15	9.93e-04	23	38	2	IPR033739
Domain	Peptidase_M10	MMP21 MMP15	1.08e-03	24	38	2	PF00413
Domain	ZnMc	MMP21 MMP15	1.58e-03	29	38	2	SM00235
Domain	Peptidase_Metallo	MMP21 MMP15	1.58e-03	29	38	2	IPR006026
Domain	CYSTEINE_SWITCH	MMP21 MMP15	3.14e-03	41	38	2	PS00546
Domain	Pept_M10_metallopeptidase	MMP21 MMP15	3.45e-03	43	38	2	IPR001818
Pathway	REACTOME_MULTIFUNCTIONAL_ANION_EXCHANGERS	SLC26A7 SLC26A1	1.56e-04	9	30	2	M27344
Pathway	REACTOME_MULTIFUNCTIONAL_ANION_EXCHANGERS	SLC26A7 SLC26A1	1.56e-04	9	30	2	MM15084
Pubmed	Deletion of Slc26a1 and Slc26a7 Delays Enamel Mineralization in Mice.	SLC26A7 SLC26A1	1.23e-06	2	39	2	28559854
Pubmed	Gliomedin mediates Schwann cell-axon interaction and the molecular assembly of the nodes of Ranvier.	GLDN NRCAM	1.23e-06	2	39	2	16039564
Pubmed	The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development.	EPHB2 TIAM1	1.23e-06	2	39	2	17440041
Pubmed	Long-term maintenance of Na+ channels at nodes of Ranvier depends on glial contact mediated by gliomedin and NrCAM.	GLDN NRCAM	1.23e-06	2	39	2	24719088
Pubmed	Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation.	RALGAPA2 NLRP3	1.23e-06	2	39	2	31622786
Pubmed	SLC26A Gene Family Participate in pH Regulation during Enamel Maturation.	SLC26A7 SLC26A1	3.67e-06	3	39	2	26671068
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	EPHB2 FANCD2 PATL1 HACD2 SNAPC3 GID4 CTR9 YARS2 NUP205	1.26e-05	1327	39	9	32694731
Pubmed	A glial signal consisting of gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier.	GLDN NRCAM	1.83e-05	6	39	2	20188654
Pubmed	Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling.	GLDN NRCAM	1.83e-05	6	39	2	23897819
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	FANCD2 TRAPPC10 PATL1 ERCC5 CTR9 ACLY ZNF644	2.18e-05	774	39	7	15302935
Pubmed	EphB regulates L1 phosphorylation during retinocollicular mapping.	EPHB2 NRCAM	2.56e-05	7	39	2	22579729
Pubmed	Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2.	EPHB2 TIAM1	3.42e-05	8	39	2	14988728
Pubmed	Physiological roles and regulation of mammalian sulfate transporters.	SLC26A7 SLC26A1	4.39e-05	9	39	2	11581495
Pubmed	Placental, renal, and ileal sulfate transporter gene expression in mouse gestation.	SLC26A7 SLC26A1	4.39e-05	9	39	2	22674389
Pubmed	Neurofascin 140 is an embryonic neuronal neurofascin isoform that promotes the assembly of the node of Ranvier.	GLDN NRCAM	4.39e-05	9	39	2	25653379
Pubmed	N-glycosylation and topology of the human SLC26 family of anion transport membrane proteins.	SLC26A7 SLC26A1	5.48e-05	10	39	2	24647542
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	CNOT6 TRAPPC10 HACD2 PRPF8 TIAM1 GID4 CTR9 NUP205	9.13e-05	1321	39	8	27173435
Pubmed	gdnf activates midline repulsion by Semaphorin3B via NCAM during commissural axon guidance.	NRCAM PLXNA1	9.48e-05	13	39	2	22998873
Pubmed	Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.	RRM1 PRPF8 MMP15 CTR9 ACLY	1.05e-04	422	39	5	27342126
Pubmed	Human Pat1b connects deadenylation with mRNA decapping and controls the assembly of processing bodies.	CNOT6 PATL1	1.11e-04	14	39	2	20584987
Pubmed	A midline switch of receptor processing regulates commissural axon guidance in vertebrates.	NRCAM PLXNA1	1.11e-04	14	39	2	20159958
Pubmed	Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing.	NRCAM PLXNA1	1.46e-04	16	39	2	22632726
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	EPHB2 FANCD2 CYP4F8 HACD2 MMP15 PLXNA1 NUP205	1.58e-04	1061	39	7	33845483
Pubmed	SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.	FANCD2 RRM1 PRPF8 CTR9 NUP205	1.62e-04	463	39	5	34901782
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	CNOT6 RALGAPA2 ZNF644	2.13e-04	103	39	3	10574462
Pubmed	Functional interactions between matrix metalloproteinases and glycosaminoglycans.	MMP21 MMP15	2.79e-04	22	39	2	23421805
Pubmed	Zic2-dependent axon midline avoidance controls the formation of major ipsilateral tracts in the CNS.	EPHB2 PLXNA1	3.05e-04	23	39	2	24360543
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	TRMT5 ZNF644 YARS2 NUP205	5.70e-04	341	39	4	32971831
Pubmed	Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway.	RRM1 ACLY	6.33e-04	33	39	2	29149599
Pubmed	alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus.	FANCD2 ERCC5	6.72e-04	34	39	2	16889989
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	RRM1 PRPF8 CTR9 ACLY NUP205	7.03e-04	638	39	5	33239621
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	PATL1 RRM1 PRPF8 CTR9 ACLY	7.80e-04	653	39	5	33742100
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	PATL1 ERCC5 RRM1 PRPF8 CTR9 ACLY YARS2	8.92e-04	1415	39	7	28515276
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	FANCD2 PRPF8 CTR9 ACLY PLXNA1 YARS2 NUP205	9.29e-04	1425	39	7	30948266
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	RRM1 PRPF8 ACLY	1.07e-03	179	39	3	36261009
Pubmed	Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.	PRPF8 CTR9	1.07e-03	43	39	2	26030138
Cytoband	13q33	ERCC5 POGLUT2	7.02e-06	5	39	2	13q33
Cytoband	Ensembl 112 genes in cytogenetic band chr13q33	ERCC5 POGLUT2	1.01e-03	55	39	2	chr13q33
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP21 MMP15	4.58e-04	24	24	2	891
GeneFamily	Fibronectin type III domain containing	EPHB2 NRCAM	1.89e-02	160	24	2	555
CoexpressionAtlas	dev gonad_e11.5_M_SupCellPrec_Sry_k-means-cluster#3_top-relative-expression-ranked_1000	GLDN HACD2 RALGAPA2 TIAM1 MMP15 SLC26A7	6.05e-06	251	39	6	gudmap_dev gonad_e11.5_M_SupCellPrec_Sry_k3_1000
Computational	Neighborhood of MLL	CNOT6 TEX261 PATL1 PRPF8 ZNF644	4.29e-05	174	25	5	GCM_MLL
Computational	Nucleotide metabolism.	RRM1 ACLY NUP205	4.22e-04	64	25	3	MODULE_337
Computational	Neighborhood of NF2	TEX261 PATL1 SNAPC3 PRPF8 ZNF644	5.67e-04	302	25	5	GCM_NF2

Protein segments in the cluster

Peptide	Gene	Start	Entry
YFDRKYLFANSKTYF	GLDN	411	Q6ZMI3
KYYTFNSKDAAYSFA	CFAP206	446	Q8IYR0
IYLLKQSANDFFSYY	NUP205	1816	Q92621
FYYQNYFEKLEKLSA	PATL1	431	Q86TB9
KNLNFSTRYKFYFYA	NRCAM	1016	Q92823
YYFTLESFQKSFYIN	LPAR4	311	Q99677
GAFLSNDAAYTYFYK	MMP15	516	P51511
FNLYYYEADFDSATK	EPHB2	111	P29323
AFDIYYVYSFRSEQF	PLXNA1	241	Q9UIW2
IDSAYYSYAYNSIFF	MMP21	506	Q8N119
YSYAYNSIFFFKGNA	MMP21	511	Q8N119
FFETNYSQIYFIFYE	RALGAPA2	46	Q2PPJ7
LAFYQYAKSFNSDDF	GID4	206	Q8IVV7
DDVLIYLNSFKSYFY	TTC26	376	A0AVF1
YLNSFKSYFYNDDIF	TTC26	381	A0AVF1
KSYFYNDDIFNFNYA	TTC26	386	A0AVF1
FAFQIQFYYSEFLDS	CSTPP1	141	Q9H6J7
NVDLSSNFYFSYSYD	FIG4	156	Q92562
NKYNFSFDYYAFLIL	HACD2	206	Q6Y1H2
NNQFFRYKDFLYFLT	CYP4F8	236	P98187
FQYYYQATQFASSSF	CTR9	326	Q6PD62
ASYLFQQDKFYDVSY	GADL1	361	Q6ZQY3
NYTFDFKGIIDYIFY	CNOT6	481	Q9ULM6
LLYKYAFKFFDTYCQ	FANCD2	456	Q9BXW9
YFFKYFSDEAQARAA	NLRP3	381	Q96P20
RENNYTYEFDFSKVY	TRMT5	266	Q32P41
LAEFFYQVLQAYDFY	YARS2	216	Q9Y2Z4
DYKLAFKYFYLASQS	SEL1L2	426	Q5TEA6
FNKNKFVEYYQYVDF	ERCC5	826	P28715
LYKSAFFYFEGTFYN	SNAPC3	246	Q92966
SGLFNFYEDLYFTYL	ACLY	186	P53396
LKAYYAFKIYDFNND	CIB3	106	Q96Q77
DDNYFYLFDLKAFFT	PRPF8	251	Q6P2Q9
LLVYFLAFDQKSYFY	TMPRSS11D	36	O60235
YYQTFFDVDTYQVFD	YIPF1	81	Q9Y548
SFLYYADRFKLYSAF	TIAM1	1131	Q13009
IYDRDFSYNYFGFKT	RRM1	136	P23921
FSYNYFGFKTLERSY	RRM1	141	P23921
LYYANKDFFLQSLYS	SLC26A1	546	Q9H2B4
VNHYLAFQFFAEEYY	TEX261	106	Q6UWH6
DIFCYYFKLFQEYAN	POGLUT2	451	Q6UW63
ATLSYDQNDGFYFEY	ZNF644	906	Q9H582
FYFEYYEDTGSNNFL	ZNF644	916	Q9H582
YTYEFKVENFFTLYN	TRAPPC10	1046	P48553
GFFYIYAYVFENIKS	SLC26A7	211	Q8TE54