Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR51S1 OR52K1 GPR50 OR4C11 GPR35 TAS1R3 OR52D1 OR52E1 OR52E5 OR52K2	9.48e-05	884	53	10	GO:0004930
GeneOntologyMolecularFunction	olfactory receptor activity	OR51S1 OR52K1 OR4C11 OR52D1 OR52E1 OR52E5 OR52K2	1.36e-04	431	53	7	GO:0004984
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR51S1 OR52K1 ABCA1 GPR50 OR4C11 GPR35 TAS1R3 OR52D1 PKD1 OR52E1 OR52E5 OR52K2	1.77e-04	1353	53	12	GO:0004888
GeneOntologyMolecularFunction	thiolester hydrolase activity	ACOT8 ACOT2 ABHD12	2.64e-04	47	53	3	GO:0016790
GeneOntologyMolecularFunction	carboxylic ester hydrolase activity	ACOT8 PGAP1 ACOT2 ABHD12	7.98e-04	157	53	4	GO:0052689
GeneOntologyMolecularFunction	long-chain fatty acyl-CoA hydrolase activity	ACOT8 ACOT2	9.16e-04	17	53	2	GO:0052816
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR51S1 OR52K1 OR4C11 TAS1R3 OR52D1 OR52E1 OR52E5 OR52K2	2.68e-05	485	52	8	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR51S1 OR52K1 OR4C11 TAS1R3 OR52D1 OR52E1 OR52E5 OR52K2	4.63e-05	524	52	8	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR51S1 OR52K1 OR4C11 TAS1R3 OR52D1 OR52E1 OR52E5 OR52K2	6.26e-05	547	52	8	GO:0007606
GeneOntologyBiologicalProcess	detection of stimulus	OR51S1 OR52K1 OR4C11 TAS1R3 OR52D1 PKD1 OR52E1 OR52E5 OR52K2	7.16e-05	722	52	9	GO:0051606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR51S1 OR52K1 OR4C11 TAS1R3 OR52D1 OR52E1 OR52E5 OR52K2	9.65e-05	582	52	8	GO:0050906
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR51S1 OR52K1 OR4C11 OR52D1 OR52E1 OR52E5 OR52K2	9.99e-05	432	52	7	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR51S1 OR52K1 OR4C11 OR52D1 OR52E1 OR52E5 OR52K2	1.58e-04	465	52	7	GO:0007608
GeneOntologyBiologicalProcess	long-chain fatty acid metabolic process	ACOT8 SLC27A1 ACOT2 ABHD12	2.70e-04	124	52	4	GO:0001676
GeneOntologyBiologicalProcess	sensory perception	OR51S1 OR52K1 OR4C11 TAS1R3 PGAP1 OR52D1 OR52E1 OR52E5 OR52K2 MFRP	2.97e-04	1072	52	10	GO:0007600
Domain	EamA_dom	SLC35G3 SLC35G5 SLC35G6 SLC35G4	4.46e-08	14	50	4	IPR000620
Domain	EamA	SLC35G3 SLC35G5 SLC35G6 SLC35G4	4.46e-08	14	50	4	PF00892
Domain	7tm_1	OR51S1 OR52K1 GPR50 OR4C11 GPR35 OR52D1 OR52E5 OR52K2	3.99e-04	677	50	8	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR51S1 OR52K1 GPR50 OR4C11 GPR35 OR52D1 OR52E5 OR52K2	4.32e-04	685	50	8	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR51S1 OR52K1 GPR50 OR4C11 GPR35 OR52D1 OR52E5 OR52K2	4.57e-04	691	50	8	PS50262
Domain	GPCR_Rhodpsn	OR51S1 OR52K1 GPR50 OR4C11 GPR35 OR52D1 OR52E5 OR52K2	4.62e-04	692	50	8	IPR000276
Domain	Olfact_rcpt	OR51S1 OR52K1 OR4C11 OR52D1 OR52E5 OR52K2	6.07e-04	393	50	6	IPR000725
Domain	GPCR_Rhodpsn_7TM	OR51S1 OR52K1 GPR50 OR4C11 GPR35 OR52D1 OR52K2	1.93e-03	670	50	7	IPR017452
Domain	-	PGAP1 ACOT2 ABHD12	3.97e-03	119	50	3	3.40.50.1820
Domain	AB_hydrolase	PGAP1 ACOT2 ABHD12	3.97e-03	119	50	3	IPR029058
Domain	LDLRA_1	PKD1 MFRP	7.32e-03	48	50	2	PS01209
Domain	CUB	MFRP CSMD2	7.62e-03	49	50	2	PF00431
Domain	LDLRA_2	PKD1 MFRP	7.62e-03	49	50	2	PS50068
Domain	CUB	MFRP CSMD2	7.93e-03	50	50	2	SM00042
Domain	DnaJ_domain	SACS PDCD2L	8.24e-03	51	50	2	IPR001623
Domain	-	MFRP CSMD2	8.55e-03	52	50	2	2.60.120.290
Domain	CUB	MFRP CSMD2	8.87e-03	53	50	2	PS01180
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR51S1 OR52K1 OR4C11 OR52D1 OR52E1 OR52E5 OR52K2	9.00e-05	417	37	7	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR51S1 OR52K1 OR4C11 TAS1R3 OR52D1 OR52E1 OR52E5 OR52K2	1.98e-04	636	37	8	M41834
Pubmed	RT-PCR of fatty acid elongases.	SLC35G3 SLC35G5 SLC35G6 SLC35G4	4.80e-12	4	53	4	9056918
Pubmed	Emergence of primate genes by retrotransposon-mediated sequence transduction.	SLC35G3 SLC35G5 SLC35G6 SLC35G4	4.80e-12	4	53	4	17101974
Pubmed	Gαi-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation.	TRPC4 PKD1	6.83e-06	3	53	2	29472562
Pubmed	Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase.	ACOT8 ACOT2	6.83e-06	3	53	2	10944470
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	MBLAC1 ABCA1 RASAL3 SLC35G3 NYNRIN SLC35G5 SLC35G6 SLC35G4	7.84e-06	674	53	8	37196079
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR51S1 OR52K1 OR4C11 OR52D1 OR52E5 OR52K2	1.30e-05	340	53	6	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR51S1 OR52K1 OR4C11 OR52D1 OR52E5 OR52K2	1.30e-05	340	53	6	11802173
Pubmed	An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2.	ABCA1 NFATC2	1.36e-05	4	53	2	19752193
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR51S1 OR52K1 OR4C11 OR52D1 OR52E5 OR52K2	1.37e-05	343	53	6	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR51S1 OR52K1 OR4C11 OR52D1 OR52E5 OR52K2	1.44e-05	346	53	6	14611657
Pubmed	Differential impact of Lhx2 deficiency on expression of class I and class II odorant receptor genes in mouse.	OR51S1 OR52K1 OR52K2	1.77e-05	33	53	3	17350283
Pubmed	Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs.	ACOT8 ACOT2	2.27e-05	5	53	2	16940157
Pubmed	A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases.	ACOT8 ACOT2	8.15e-05	9	53	2	16103133
Pubmed	Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells.	TAS1R3 PKD1	1.02e-04	10	53	2	16805797
Pubmed	The human olfactory receptor gene family.	OR51S1 OR52K1 OR4C11 OR52D1 OR52E5 OR52K2	1.70e-04	541	53	6	14983052
Pubmed	Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.	ABCA1 SLC35G5	2.36e-04	15	53	2	20160193
Pubmed	Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.	ARL6IP1 PGAP1	2.36e-04	15	53	2	24482476
Pubmed	Deficiency of Lipoprotein Lipase in Neurons Decreases AMPA Receptor Phosphorylation and Leads to Neurobehavioral Abnormalities in Mice.	ABCA1 SLC27A1	2.70e-04	16	53	2	26263173
Pubmed	An Ideal PPAR Response Element Bound to and Activated by PPARα.	SLC27A1 ACOT2	4.25e-04	20	53	2	26241474
Pubmed	Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD.	NFATC2 TRPC4	8.40e-04	28	53	2	25158072
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	TAF6L MROH8 TAS1R3 SEPTIN9 PKD1 CSMD2	8.67e-04	736	53	6	29676528
Pubmed	Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population.	ABCA1 SLC35G5	9.01e-04	29	53	2	20972250
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	TRPC4 PKD1	1.17e-03	33	53	2	19834762
Cytoband	11p15.4	OR51S1 OR52K1 OR52D1 OR52E1 OR52E5 OR52K2	1.23e-07	200	53	6	11p15.4
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	OR51S1 OR52K1 OR52D1 OR52E1 OR52E5 OR52K2	4.71e-05	564	53	6	chr11p15
GeneFamily	Olfactory receptors, family 52	OR52K1 OR52D1 OR52E1 OR52E5 OR52K2	8.26e-08	49	41	5	165
GeneFamily	Solute carriers	SLC35G3 SLC27A1 SLC10A4 SLC35G5 SLC35G6 SLC16A8 SLC35G4	2.67e-05	395	41	7	752
GeneFamily	Acyl-CoA thioesterases	ACOT8 ACOT2	2.23e-04	10	41	2	41
ToppCell	LPS_only-Hematopoietic_Mast-Mast_cells-T-cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RASAL3 NFATC2 GPR35 GIMAP2 ABHD12	9.72e-07	150	53	5	ccb782fbcb3122266354a112a9a850506664f44d
Disease	familial hyperlipidemia (biomarker_via_orthology)	ABCA1 SLC27A1	4.72e-04	19	50	2	DOID:1168 (biomarker_via_orthology)
Disease	obsessive-compulsive disorder, Tourette syndrome	NFATC2 TRPC4	8.91e-04	26	50	2	EFO_0004242, EFO_0004895
Disease	free cholesterol in small HDL measurement	ABCA1 NYNRIN	1.62e-03	35	50	2	EFO_0022270
Disease	unipolar depression, age at onset	INTU DCLK3	2.11e-03	40	50	2	EFO_0003761, EFO_0004847
Disease	Thromboembolism	OR52K1 OR52K2	2.54e-03	44	50	2	HP_0001907

Protein segments in the cluster

Peptide	Gene	Start	Entry
HCYFVRAGDPKLPVL	ACOT8	81	O14734
PYCSLPRAPLHGFIL	CSMD2	2466	Q7Z408
VFLIFPHFCLGRGLI	ABCA1	1806	O95477
PPYFPLCRASLHALV	ACOT2	426	P49753
FLCLADYLVPILAPR	ARL6IP1	76	Q15041
FHYARLCGALEPALP	RASAL3	441	Q86YV0
VLGYRAGPACPFLLH	FMN1	651	Q68DA7
GLARLRPHVPYLFSL	SLC16A8	311	O95907
YGLATLFHLPPNCKR	SLC10A4	316	Q96EP9
GLYIAIPFLIKLCPG	ABHD12	81	Q8N2K0
PCYQHFRRLLCGLLV	MFRP	511	Q9BY79
PFIFLLRRLPYCGHR	OR52D1	161	Q9H346
IPFVLFILRLPFCGH	OR52E1	156	Q8NGJ3
FILRLPFCGHQIIPH	OR52E1	161	Q8NGJ3
LPRHIYPAVEFLGPC	NFATC2	341	Q13469
LLYLLPRCFTPGEAL	DOLK	181	Q9UPQ8
HFVLPLLIVGFCYVR	GPR50	196	Q13585
VILYILLCGFPPFRS	DCLK3	541	Q9C098
ISFRCLGLHLPLPFL	OR51S1	156	Q8NGJ8
QVYCPLEGSPFHRLL	PDCD2L	61	Q9BRP1
VHLCRGVFPLLYREP	PKLR	506	P30613
AQIILALRLPFCGPY	OR4C11	156	Q6IEV9
IVLSFLLCHPVPYNR	MROH8	421	Q9H579
PLLGFYLPLAVVVFC	GPR35	176	Q9HC97
LALCVGLFLPHHPFL	PLEKHH2	1046	Q8IVE3
GRLFLHPKPQELYVC	INTU	906	Q9ULD6
QRCYLLSAPGPHVLL	GIMAP2	96	Q9UG22
PLDPCLYRGLLLVHR	B3GNT4	336	Q9C0J1
LLLVCHASGFYPKPV	CD1C	221	P29017
LHLLLGPCTPIHYRV	FMO5	461	P49326
LLVSHDFCLPGGRYL	MBLAC1	131	A4D2B0
FCYLPLRIKTGLPVH	SACS	1871	Q9NZJ4
FYHCLVAEILPAPGK	SAT2	51	Q96F10
SLLACLPAGPRVYFL	DUSP5	111	Q16690
LRHPKRILFGTDYCP	PRAMEF26	351	H0Y7S4
LVLPRLALPVGHYCF	PKD1	2216	P98161
VRYPPILHCAFLGAQ	NYNRIN	81	Q9P2P1
LRLPFCGVRIIPHTY	OR52E5	166	Q8NH55
LPFLLRRFHYCRGPV	OR52K1	161	Q8NGK4
LPFLLRCFHYCRGPV	OR52K2	161	Q8NGK3
RSLFRNPHLCLGPYV	TAF6L	221	Q9Y6J9
GLLVYRSLHFPSCLP	SLC35G5	206	Q96KT7
RLLVYRSLHFPPCLP	SLC35G3	206	Q8N808
ILLKYRCHGPPIRFT	NXPE3	401	Q969Y0
CLYFIPATGHSLRPL	SEPTIN9	411	Q9UHD8
HLYRLPCFVFIPLLL	PGAP1	901	Q75T13
GLLVYRSLHFPSCLP	SLC35G4	206	P0C7Q5
CVLGILAAFHLPRCY	TAS1R3	801	Q7RTX0
CGFNSRILPHVYPIR	SLC27A1	406	Q6PCB7
DILVPGLLVAYCHRF	SPPL2B	421	Q8TCT7
GLLVYRSLHFPSCLP	SLC35G6	206	P0C7Q6
IDPCLYIPRFAHLLE	BRF1	181	Q92994
VGFGNYRPFLCLLLH	ZDHHC24	131	Q6UX98
YRPFLCLLLHAAGVL	ZDHHC24	136	Q6UX98
CYLIAPKSPLGLFIR	TRPC4	346	Q9UBN4