Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	calcium activated phosphatidylserine scrambling	ANO4 ANO6	3.31e-05	4	49	2	GO:0061589
GeneOntologyBiologicalProcess	calcium activated phospholipid scrambling	ANO4 ANO6	5.50e-05	5	49	2	GO:0061588
GeneOntologyBiologicalProcess	calcium activated phosphatidylcholine scrambling	ANO4 ANO6	5.50e-05	5	49	2	GO:0061590
GeneOntologyBiologicalProcess	calcium activated galactosylceramide scrambling	ANO4 ANO6	5.50e-05	5	49	2	GO:0061591
GeneOntologyCellularComponent	basement membrane	NID2 ACAN NTN3 LAMB1	1.49e-04	122	46	4	GO:0005604
MousePheno	polyhydramnios	ACAN PKD1	1.82e-05	3	35	2	MP:0004020
MousePheno	abnormal cochlear sensory neuron innervation pattern	MYO7A PAX8 ACAN	2.14e-05	22	35	3	MP:0014489
MousePheno	abnormal sensory neuron innervation pattern	MYO7A PAX8 ACAN NTN3	7.87e-05	92	35	4	MP:0000968
MousePheno	abnormal thyroid follicular cell morphology	PAX8 TG	1.27e-04	7	35	2	MP:0004697
Domain	ZnF_C3H1	MKRN4P ZC3H10 MKRN1 HELZ	5.29e-06	48	45	4	SM00356
Domain	zf-CCCH	MKRN4P ZC3H10 MKRN1 HELZ	5.75e-06	49	45	4	PF00642
Domain	Znf_CCCH	MKRN4P ZC3H10 MKRN1 HELZ	1.13e-05	58	45	4	IPR000571
Domain	REJ	PKD1L1 PKD1	3.40e-05	4	45	2	PS51111
Domain	REJ_dom	PKD1L1 PKD1	3.40e-05	4	45	2	IPR014010
Domain	PKD/REJ-like	PKD1L1 PKD1	8.46e-05	6	45	2	IPR002859
Domain	REJ	PKD1L1 PKD1	8.46e-05	6	45	2	PF02010
Domain	Anoct_dimer	ANO4 ANO6	1.18e-04	7	45	2	PF16178
Domain	Anoct_dimer	ANO4 ANO6	1.18e-04	7	45	2	IPR032394
Domain	PKD	PKD1L1 PKD1	1.18e-04	7	45	2	PF00801
Domain	-	ZC3H10 MKRN1 HELZ	1.21e-04	40	45	3	4.10.1000.10
Domain	PKD/Chitinase_dom	PKD1L1 PKD1	2.02e-04	9	45	2	IPR022409
Domain	MYTH4	PLEKHH1 MYO7A	2.02e-04	9	45	2	PS51016
Domain	MyTH4_dom	PLEKHH1 MYO7A	2.02e-04	9	45	2	IPR000857
Domain	MyTH4	PLEKHH1 MYO7A	2.02e-04	9	45	2	PF00784
Domain	PKD	PKD1L1 PKD1	2.02e-04	9	45	2	SM00089
Domain	MyTH4	PLEKHH1 MYO7A	2.02e-04	9	45	2	SM00139
Domain	Anoctamin	ANO4 ANO6	2.52e-04	10	45	2	PF04547
Domain	Anoctamin	ANO4 ANO6	2.52e-04	10	45	2	IPR007632
Domain	PKD	PKD1L1 PKD1	3.08e-04	11	45	2	PS50093
Domain	PKD_dom	PKD1L1 PKD1	3.08e-04	11	45	2	IPR000601
Domain	PKD_channel	PKD1L1 PKD1	3.08e-04	11	45	2	PF08016
Domain	PKD1_2_channel	PKD1L1 PKD1	3.08e-04	11	45	2	IPR013122
Domain	-	PKD1L1 PKD1	3.08e-04	11	45	2	2.60.40.670
Domain	ZF_C3H1	ZC3H10 MKRN1 HELZ	3.68e-04	58	45	3	PS50103
Domain	Laminin_N	NTN3 LAMB1	6.67e-04	16	45	2	IPR008211
Domain	LAMININ_NTER	NTN3 LAMB1	6.67e-04	16	45	2	PS51117
Domain	Laminin_N	NTN3 LAMB1	6.67e-04	16	45	2	PF00055
Domain	LamNT	NTN3 LAMB1	6.67e-04	16	45	2	SM00136
Domain	TY	NID2 TG	7.54e-04	17	45	2	SM00211
Domain	-	NID2 TG	7.54e-04	17	45	2	4.10.800.10
Domain	THYROGLOBULIN_1_2	NID2 TG	7.54e-04	17	45	2	PS51162
Domain	Thyroglobulin_1	NID2 TG	7.54e-04	17	45	2	IPR000716
Domain	Thyroglobulin_1	NID2 TG	7.54e-04	17	45	2	PF00086
Domain	THYROGLOBULIN_1_1	NID2 TG	7.54e-04	17	45	2	PS00484
Domain	LH2	PKD1L1 PKD1	8.47e-04	18	45	2	SM00308
Domain	PLAT	PKD1L1 PKD1	1.16e-03	21	45	2	PS50095
Domain	-	PKD1L1 PKD1	1.16e-03	21	45	2	2.60.60.20
Domain	PLAT	PKD1L1 PKD1	1.16e-03	21	45	2	PF01477
Domain	PLAT/LH2_dom	PKD1L1 PKD1	1.16e-03	21	45	2	IPR001024
Domain	EGF_LAM_2	NTN3 LAMB1	2.37e-03	30	45	2	PS50027
Domain	EGF_LAM_1	NTN3 LAMB1	2.37e-03	30	45	2	PS01248
Domain	Laminin_EGF	NTN3 LAMB1	3.21e-03	35	45	2	PF00053
Domain	EGF_Lam	NTN3 LAMB1	3.21e-03	35	45	2	SM00180
Domain	GPS	PKD1L1 PKD1	3.39e-03	36	45	2	PS50221
Domain	EGF-like_CS	NID2 NTN3 LAMB1 MASP2	3.54e-03	261	45	4	IPR013032
Domain	GPS	PKD1L1 PKD1	3.58e-03	37	45	2	IPR000203
Domain	EGF_2	NID2 NTN3 LAMB1 MASP2	3.74e-03	265	45	4	PS01186
Domain	Laminin_EGF	NTN3 LAMB1	3.78e-03	38	45	2	IPR002049
Domain	Keratin_I	KRT27 KRT25	5.04e-03	44	45	2	IPR002957
Domain	FERM_M	PLEKHH1 MYO7A	5.49e-03	46	45	2	PF00373
Domain	-	PLEKHH1 MYO7A	6.21e-03	49	45	2	1.20.80.10
Domain	FERM_central	PLEKHH1 MYO7A	6.21e-03	49	45	2	IPR019748
Domain	FERM_domain	PLEKHH1 MYO7A	6.21e-03	49	45	2	IPR000299
Domain	Growth_fac_rcpt_	NID2 NTN3 LAMB1	6.27e-03	156	45	3	IPR009030
Domain	FERM_1	PLEKHH1 MYO7A	6.46e-03	50	45	2	PS00660
Domain	FERM_2	PLEKHH1 MYO7A	6.46e-03	50	45	2	PS00661
Domain	FERM_3	PLEKHH1 MYO7A	6.46e-03	50	45	2	PS50057
Domain	Band_41_domain	PLEKHH1 MYO7A	6.46e-03	50	45	2	IPR019749
Domain	B41	PLEKHH1 MYO7A	6.46e-03	50	45	2	SM00295
Domain	FERM/acyl-CoA-bd_prot_3-hlx	PLEKHH1 MYO7A	6.46e-03	50	45	2	IPR014352
Pathway	REACTOME_SARS_COV_2_INFECTION	ANO4 VPS11 NOD1 ANO6 STAT2 MASP2	9.87e-05	299	36	6	M41727
Pubmed	Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J.	MKRN4P ZSWIM9 ACAN MKRN1	1.12e-06	55	49	4	29997285
Pubmed	Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma.	MKRN4P MKRN1	1.94e-06	2	49	2	19604354
Pubmed	The putatively functional Mkrn1-p1 pseudogene is neither expressed nor imprinted, nor does it regulate its source gene in trans.	MKRN4P MKRN1	1.94e-06	2	49	2	16882727
Pubmed	Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation.	MKRN4P MKRN1	1.94e-06	2	49	2	30143610
Pubmed	An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene.	MKRN4P MKRN1	1.94e-06	2	49	2	12721631
Pubmed	Origin and evolution of processed pseudogenes that stabilize functional Makorin1 mRNAs in mice, primates and other mammals.	MKRN4P MKRN1	1.94e-06	2	49	2	16415359
Pubmed	Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation.	EEF1AKMT4-ECE2 EEF1AKMT4	5.83e-06	3	49	2	28520920
Pubmed	The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system.	MKRN4P MKRN1	5.83e-06	3	49	2	10843807
Pubmed	Suppression of PPARγ through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation.	MKRN4P MKRN1	5.83e-06	3	49	2	24336050
Pubmed	K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle.	KRT27 KRT25	5.83e-06	3	49	2	16874310
Pubmed	Acceleration of gastric tumorigenesis through MKRN1-mediated posttranslational regulation of p14ARF.	MKRN4P MKRN1	5.83e-06	3	49	2	23104211
Pubmed	Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament.	KRT27 KRT25	1.16e-05	4	49	2	17920809
Pubmed	Iodinated TG in Thyroid Follicular Lumen Regulates TTF-1 and PAX8 Expression via TSH/TSHR Signaling Pathway.	PAX8 TG	1.16e-05	4	49	2	28322461
Pubmed	TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation.	PAX8 TG	1.16e-05	4	49	2	19010321
Pubmed	Minireview: thyrotropin receptor signaling in development and differentiation of the thyroid gland: insights from mouse models and human diseases.	PAX8 TG	1.16e-05	4	49	2	15231702
Pubmed	Phylogenetic conservation of the makorin-2 gene, encoding a multiple zinc-finger protein, antisense to the RAF1 proto-oncogene.	MKRN4P MKRN1	1.16e-05	4	49	2	11597136
Pubmed	PAX8, TITF1, and FOXE1 gene expression patterns during human development: new insights into human thyroid development and thyroid dysgenesis-associated malformations.	PAX8 TG	1.16e-05	4	49	2	15494458
Pubmed	TGF-beta-like transcriptional effects of thyroglobulin (Tg) in mouse mesangial cells.	PAX8 TG	1.16e-05	4	49	2	17495424
Pubmed	A locus on mouse chromosome 2 is involved in susceptibility to congenital hypothyroidism and contains an essential gene expressed in thyroid.	PAX8 TG	1.16e-05	4	49	2	20160132
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	ACAN PKD1L1 PKD1 PRDM1	1.23e-05	100	49	4	25807483
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	MKRN4P ZC3H10 MKRN1 ZNF76 STAT2 ZNF367 PRDM1 KLHL26	1.59e-05	808	49	8	20412781
Pubmed	Type I IFN signaling facilitates the development of IL-10-producing effector CD8+ T cells during murine influenza virus infection.	STAT2 PRDM1	1.94e-05	5	49	2	27701741
Pubmed	Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins.	PLPP5 PRDM1	1.94e-05	5	49	2	30042348
Pubmed	Follicular cells of the thyroid gland require Pax8 gene function.	PAX8 TG	1.94e-05	5	49	2	9590297
Pubmed	Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly.	PAX8 LAMB1 TG	2.50e-05	40	49	3	27068110
Pubmed	DYRK1A BAC transgenic mouse: a new model of thyroid dysgenesis in Down syndrome.	PAX8 TG	2.91e-05	6	49	2	25490145
Pubmed	Identification and characterization of TMEM16E and TMEM16F genes in silico.	ANO4 ANO6	2.91e-05	6	49	2	15067359
Pubmed	Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis.	MKRN4P MKRN1	2.91e-05	6	49	2	19536131
Pubmed	A mouse model demonstrates a multigenic origin of congenital hypothyroidism.	PAX8 TG	2.91e-05	6	49	2	16150900
Pubmed	TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation.	PAX8 TG	4.07e-05	7	49	2	9214635
Pubmed	Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3.	NTN3 PKD1	4.07e-05	7	49	2	8828041
Pubmed	ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins.	ANO4 ANO6	4.07e-05	7	49	2	22075693
Pubmed	Role of hindbrain in inner ear morphogenesis: analysis of Noggin knockout mice.	PAX8 ACAN	4.07e-05	7	49	2	17900554
Pubmed	Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.	NID2 FGFBP3 LAMB1	4.92e-05	50	49	3	23658023
Pubmed	Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development.	NID2 LAMB1	5.42e-05	8	49	2	12015298
Pubmed	The developing mouse thyroid: embryonic vessel contacts and parenchymal growth pattern during specification, budding, migration, and lobulation.	PAX8 TG	5.42e-05	8	49	2	16331648
Pubmed	Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland.	PAX8 TG	5.42e-05	8	49	2	12432093
Pubmed	Anoctamins are a family of Ca2+-activated Cl- channels.	ANO4 ANO6	5.42e-05	8	49	2	22946059
Pubmed	Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins.	MKRN4P MKRN1	5.42e-05	8	49	2	15522233
Pubmed	Perturbed thyroid morphology and transient hypothyroidism symptoms in Hoxa5 mutant mice.	PAX8 TG	6.96e-05	9	49	2	12815622
Pubmed	Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation.	MYO7A PAX8	6.96e-05	9	49	2	20727173
Pubmed	Borealin/CDCA8 deficiency alters thyroid development and results in papillary tumor-like structures.	PAX8 TG	8.69e-05	10	49	2	37964961
Pubmed	Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells.	PKD1L1 PKD1	8.69e-05	10	49	2	16805797
Pubmed	Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels.	ANO4 ANO6	8.69e-05	10	49	2	19015192
Pubmed	Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members.	ANO4 ANO6	8.69e-05	10	49	2	23532839
Pubmed	In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1.	PAX8 TG	8.69e-05	10	49	2	21345181
Pubmed	Structure and function of TMEM16 proteins (anoctamins).	ANO4 ANO6	8.69e-05	10	49	2	24692353
Pubmed	Genetic Analysis Reveals a Hierarchy of Interactions between Polycystin-Encoding Genes and Genes Controlling Cilia Function during Left-Right Determination.	PKD1L1 PKD1	1.06e-04	11	49	2	27272319
Pubmed	FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus.	PAX8 TG	1.06e-04	11	49	2	19235715
Pubmed	Hes1 is required for appropriate morphogenesis and differentiation during mouse thyroid gland development.	PAX8 TG	1.06e-04	11	49	2	21364918
Pubmed	The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain.	KRT27 KRT25	1.27e-04	12	49	2	15617563
Pubmed	Gene order and genetic distance of 13 loci spanning murine chromosome 15.	HOXC9 TG	1.27e-04	12	49	2	1358803
Pubmed	A branching morphogenesis program governs embryonic growth of the thyroid gland.	PAX8 TG	1.50e-04	13	49	2	29361553
Pubmed	Early thyroid development requires a Tbx1-Fgf8 pathway.	PAX8 TG	1.50e-04	13	49	2	19389367
Pubmed	Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad.	PAX8 LAMB1	1.50e-04	13	49	2	35613264
Pubmed	The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells.	PAX8 TG	1.75e-04	14	49	2	25127920
Pubmed	Double knock-out of Hmga1 and Hipk2 genes causes perinatal death associated to respiratory distress and thyroid abnormalities in mice.	PAX8 TG	1.75e-04	14	49	2	31582725
Pubmed	Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit.	NOD1 MASP2	1.75e-04	14	49	2	19050632
Pubmed	Basement membrane composition in the early mouse embryo day 7.	NID2 LAMB1	2.02e-04	15	49	2	15895400
Pubmed	Transcriptional ontogeny of the developing liver.	MKRN4P MKRN1	2.02e-04	15	49	2	22260730
Pubmed	Polymorphisms in innate immunity genes and risk of childhood leukemia.	NOD1 ZNF76 STAT2 MASP2	2.06e-04	206	49	4	20438785
Pubmed	Risk of meningioma and common variation in genes related to innate immunity.	NOD1 ZNF76 STAT2 MASP2	2.09e-04	207	49	4	20406964
Pubmed	Common variation in genes related to innate immunity and risk of adult glioma.	NOD1 ZNF76 STAT2 MASP2	2.13e-04	208	49	4	19423540
Pubmed	Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis.	PAX8 TG	2.30e-04	16	49	2	38750011
Pubmed	The microRNA-processing enzyme Dicer is essential for thyroid function.	PAX8 TG	2.61e-04	17	49	2	22132122
Pubmed	Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs.	NID2 ACAN	2.93e-04	18	49	2	12571105
Pubmed	The targeted inactivation of TRβ gene in thyroid follicular cells suggests a new mechanism of regulation of thyroid hormone production.	PAX8 TG	3.64e-04	20	49	2	24265449
Pubmed	The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.	PAX8 STAT2 TG	3.75e-04	99	49	3	19730683
Pubmed	Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation.	PAX8 TG	4.01e-04	21	49	2	23707896
Pubmed	Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron Patterning.	PAX8 LAMB1	4.41e-04	22	49	2	29449451
Pubmed	TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology.	PAX8 TG	4.41e-04	22	49	2	30446499
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	ACAN LAMB1	6.18e-04	26	49	2	34189436
Pubmed	Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.	ACAN TG	6.18e-04	26	49	2	33905568
Pubmed	Genetic link between renal birth defects and congenital heart disease.	PKD1 PRDM1	7.18e-04	28	49	2	27002738
Pubmed	Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.	NID2 LAMB1	7.71e-04	29	49	2	22613833
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	PKD1L1 PKD1	9.98e-04	33	49	2	19834762
Pubmed	Canonical Wnt signaling regulates the proliferative expansion and differentiation of fibrocytes in the murine inner ear.	MYO7A ACAN	9.98e-04	33	49	2	24727668
Pubmed	Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.	NID2 ACAN LAMB1	1.16e-03	146	49	3	27068509
GeneFamily	Anoctamins	ANO4 ANO6	1.72e-04	10	36	2	865
GeneFamily	Keratins, type I	KRT27 KRT25	1.41e-03	28	36	2	608
GeneFamily	Zinc fingers CCCH-type	ZC3H10 HELZ	2.20e-03	35	36	2	73
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	ACAN PKD1	3.01e-03	41	36	2	1298
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	PLEKHH1 MYO7A	4.45e-03	50	36	2	1293
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	ACAN MASP2	5.74e-03	57	36	2	1179
GeneFamily	Ring finger proteins	MKRN4P VPS11 MKRN1	1.72e-02	275	36	3	58
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-mLTo\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXC9 RASA3 FUT7 GDF9	2.68e-05	157	49	4	c779a53b2c67d566f5d417e753cd17196a6bfd1c
ToppCell	facs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTN3 RBM15B GDF9 ZNF367	3.65e-05	170	49	4	d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCell	facs-Marrow-B-cells-24m-Hematologic-Unknown_Progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLPP5 PGM5 TG PRDM1	3.82e-05	172	49	4	65b8935a972bf00b7a10dc2d442128fc0ed78bcb
ToppCell	356C-Myeloid-Monocyte-CD16+_Monocyte\|Monocyte / Donor, Lineage, Cell class and subclass (all cells)	ZC3H10 PKD1 AP5M1 TG	3.82e-05	172	49	4	9dca1542145d88559527db7e0f6ad150df59ca2d
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NID2 HOXC9 MYO7A PGM5	3.91e-05	173	49	4	7dc988fc0ba29990567bf1bcdeb3faeeee507eb1
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLPP5 MASP2 TG PRDM1	4.18e-05	176	49	4	acb9e29773030f6452a069f8f7e53eab68ab7bd3
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLPP5 MASP2 TG PRDM1	4.18e-05	176	49	4	606704098bfdf8bfef740a3544a372fae1e75969
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-like-AT1_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANO4 METTL25B LANCL2 PRDM1	4.27e-05	177	49	4	164ffbbf798defa3728197deb1a14b661490e525
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PAX8 APCDD1L LAMB1 PGM5	4.86e-05	183	49	4	d340ab5a77e8d819a1dfb4ca3e9a4b9bc988923c
ToppCell	droplet-Thymus-nan-18m-Myeloid-Plasma_cells_and_B_cells\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLPP5 NTN3 TG PRDM1	4.86e-05	183	49	4	ffb1bbbccb34d1a7e99872611f497450039d5019
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NID2 HOXC9 APCDD1L LAMB1	5.07e-05	185	49	4	87c416d14ca6255bee39b16e7571553e36ee3069
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NID2 HOXC9 ABCA6 LAMB1	5.74e-05	191	49	4	0fae1c2ef9f83ac7721d0a9d69455bf97eed9257
ToppCell	droplet-Pancreas-Exocrine-18m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID2 LAMB1 PRRT4 PGM5	5.86e-05	192	49	4	a42aed9e563f5f4af029b8804c104f11ad227a8f
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_only / Treatment groups by lineage, cell group, cell type	NID2 ABCA6 RASA3 LAMB1	6.73e-05	199	49	4	fde2b65afde69f402f1b7b056eaa266e9fd5b227
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	NID2 ABCA6 RASA3 LAMB1	6.73e-05	199	49	4	8b86c69aaf60feff53aa782559cfece7342a23de
ToppCell	facs-Brain_Non-Myeloid-Hippocampus\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO4 PLEKHH1 ADO RASA3	6.86e-05	200	49	4	fc28f71ca1cd0fdae66009ae5afe175d22f2bd8c
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO4 PLEKHH1 ADO RASA3	6.86e-05	200	49	4	56f1f007ba8c9188a4b10e52744f1e50dc0f155a
Disease	Ulcerative Colitis	LAMB1 MASP2 PRDM1	1.23e-04	63	45	3	C0009324
Disease	Congenital Hypothyroidism	PAX8 TG	1.76e-04	13	45	2	C0010308
Disease	congenital hypothyroidism (implicated_via_orthology)	PAX8 TG	2.05e-04	14	45	2	DOID:0050328 (implicated_via_orthology)
Disease	brain age measurement	EEF1AKMT4-ECE2 EEF1AKMT4	4.25e-04	20	45	2	EFO_0010602
Disease	Sclerocystic Ovaries	ZSWIM9 FUT7 GDF9	1.39e-03	144	45	3	C1136382
Disease	Polycystic Ovary Syndrome	ZSWIM9 FUT7 GDF9	1.39e-03	144	45	3	C0032460

Protein segments in the cluster

Peptide	Gene	Start	Entry
PYDPDDGRDCHYYRV	ADO	211	Q96SZ5
DGRDCHYYRVLEPVR	ADO	216	Q96SZ5
LPYGDERHYSPLFFL	ABCA6	421	Q8N139
RAHQFYYEDPFCGEP	APCDD1L	86	Q8NCL9
YYEDPFCGEPAHSLL	APCDD1L	91	Q8NCL9
CRYRDYRDPPHSLVP	ANO4	856	Q32M45
CFYKHMYPDGRREEP	MKRN4P	421	Q13434
DDRGRPYGYPAVCEE	RBM15B	311	Q8NDT2
LECPFERQHYPEAYA	PAX8	236	Q06710
YGEDFYCEIPRSFRH	RASA3	61	Q14644
GRHYYCRFDYEGLDP	PGM5	426	Q15124
GNHTTCRYRDFRYPP	ANO6	801	Q4KMQ2
CRYRDFRYPPGHPQE	ANO6	806	Q4KMQ2
AYRGHPERCAAYAAR	FGFBP3	91	Q8TAT2
YALKPDAYPGRRADC	HOXC9	116	P31274
LDYGAHGCRIPDRPY	LANCL2	401	Q9NS86
CDRYPHLPRSQVYED	FUT7	321	Q11130
QDLLFKHYCYPERDP	NOD1	251	Q9Y239
KHYCYPERDPEEVFA	NOD1	256	Q9Y239
GSCRGLDHDYSRYFP	KRT27	126	Q7Z3Y8
GSCRGLDHDYSRYFP	KRT25	121	Q7Z3Z0
YYQHPERDIRDPNFC	LAMB1	381	P07942
PGYELPYRLREGACH	METTL25B	306	Q96FB5
FEFCEAHIPFYNRGP	AP5M1	351	Q9H0R1
DRLYEHYPAEFPCRI	HELZ	846	P42694
YPIHTPREGCYGDKD	ACAN	211	P16112
YAYPGARFHIPQCDE	NID2	951	Q14112
HYCREGFYRDPGRAL	NTN3	351	O00634
PELPERNCGYREVEY	EEF1AKMT4-ECE2	11	P0DPD8
GEGAVDACYRYDPHL	KLHL26	376	Q53HC5
DIICPRAEAGRPYEY	EFNB1	61	P98172
APPGYRLRLYFTHFD	MASP2	51	O00187
IVAPHRYNPRYCKGD	GDF9	371	O60383
LPRYHGNDCLGEDLY	PKD1L1	1286	Q8TDX9
YHCQRDEYPPPARRQ	FAM166A	176	Q6J272
DEPRAEHSYLRPGDY	PKD1	2106	P98161
CFYKHAYPDGRREEP	MKRN1	386	Q9UHC7
YFNDVDRDDGRYPPR	XG	86	P55808
PRIPRDEAFGCYYQE	STAT2	666	P52630
PFGFLDRYDPDHVCN	SELENOO	351	Q9BVL4
CRDFAERLHYPYPGE	PRDM1	201	O75626
PELPERNCGYREVEY	EEF1AKMT4	11	P0DPD7
YLYQPDERGPCFAFE	VPS11	256	Q9H270
ACPLEFAYYFRPGHL	ZSWIM9	126	Q86XI8
EGCYEEYRGRSPDAH	RBMXL3	386	Q8N7X1
PEYTCIYRFRVHGEP	SUN2	701	Q9UH99
PDFFYRCFPDGLAHS	PLPP5	116	Q8NEB5
PLFYDAYGHRDRLPA	PRRT4	416	C9JH25
YYRSHEDKRPLGCLP	PLEKHH1	716	Q9ULM0
RHDLYDIYDLPDRGF	ZC3H10	186	Q96K80
KRTHTGERPYLCDYP	ZNF367	186	Q7RTV3
FGHPYVPSCRRNGDY	TG	311	P01266
ERAHTGDRPYRCDFP	ZNF76	186	P36508
PGYAPYCEERLRRTF	MYO7A	1221	Q13402