Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

STARD13 GAPVD1 TBC1D15 IQSEC2 RASGEF1A ARHGAP17 PREX2 ARAP3 SIPA1L1 KNDC1 AKAP13 HERC2 ARHGEF2 SOS2

1.31e-0450717214GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

STARD13 GAPVD1 TBC1D15 IQSEC2 RASGEF1A ARHGAP17 PREX2 ARAP3 SIPA1L1 KNDC1 AKAP13 HERC2 ARHGEF2 SOS2

1.31e-0450717214GO:0030695
GeneOntologyMolecularFunctionsolute:inorganic anion antiporter activity

SLC26A3 SLC22A11 SLC4A3 SLC4A11

1.58e-04321724GO:0005452
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

GAPVD1 IQSEC2 RASGEF1A PREX2 KNDC1 AKAP13 HERC2 ARHGEF2 SOS2

1.82e-042311729GO:0005085
GeneOntologyBiologicalProcessheart development

IFT140 FAT4 FN1 PKD1L1 LRRC10 APC MYLK2 AXIN2 LEFTY2 TBX18 LEFTY1 BMPR2 NPHP3 MTHFD1 VCAN DCHS1 AKAP13 NOS3 NOTCH2 PCNT DNAH11

1.44e-0675717221GO:0007507
GeneOntologyBiologicalProcessaxis specification

PKD1L1 APC AXIN2 LEFTY2 TBX18 LEFTY1 PCSK6 NOTCH2

4.83e-061131728GO:0009798
GeneOntologyBiologicalProcessprotein retention in Golgi apparatus

VPS13C VPS13D SORL1

5.63e-0651723GO:0045053
GeneOntologyBiologicalProcessregulation of organelle organization

IFT140 TBC1D15 VPS13C TOM1 APC CUL9 ARHGAP17 PIWIL2 NUF2 CUL7 AXIN2 DDX11 PIKFYVE LMOD3 GDA VPS13D CELSR1 MAPK15 SIPA1L1 SVIL PAN2 AKAP13 ARHGEF2 ARMH3 CX3CL1 CDH5 CNOT1 SMG6

6.29e-06134217228GO:0033043
GeneOntologyBiologicalProcessheart morphogenesis

FAT4 APC MYLK2 AXIN2 LEFTY2 LEFTY1 BMPR2 NPHP3 DCHS1 NOS3 NOTCH2 DNAH11

1.69e-0532117212GO:0003007
GeneOntologyBiologicalProcesscirculatory system development

STARD13 IFT140 FAT4 FN1 PKD1L1 LRRC10 APC CUL7 ITGA5 MYLK2 AXIN2 LEFTY2 TBX18 LEFTY1 BMPR2 NPHP3 NFATC2 MTHFD1 VCAN DCHS1 AKAP13 CX3CL1 CDH5 EIF2AK3 NOS3 NOTCH2 PCNT DNAH11

2.36e-05144217228GO:0072359
GeneOntologyBiologicalProcesshomophilic cell adhesion via plasma membrane adhesion molecules

FAT4 FAT3 DSCAML1 CELSR1 HMCN2 PTPRF DCHS1 NECTIN4 CDH5

2.82e-051871729GO:0007156
GeneOntologyBiologicalProcesspattern specification process

IFT140 PKD1L1 APC DSCAML1 AXIN2 LEFTY2 TBX18 LEFTY1 BMPR2 CELSR1 NPHP3 PCSK6 DCHS1 NOTCH2 DNAH11

3.64e-0552617215GO:0007389
GeneOntologyBiologicalProcessdetermination of left/right symmetry

IFT140 PKD1L1 LEFTY2 LEFTY1 NPHP3 PCSK6 NOTCH2 DNAH11

4.61e-051541728GO:0007368
GeneOntologyBiologicalProcessheart valve development

APC AXIN2 BMPR2 DCHS1 NOS3 NOTCH2

4.82e-05781726GO:0003170
GeneOntologyBiologicalProcessregionalization

IFT140 PKD1L1 APC DSCAML1 AXIN2 LEFTY2 TBX18 LEFTY1 BMPR2 CELSR1 NPHP3 PCSK6 NOTCH2 DNAH11

5.01e-0547817214GO:0003002
GeneOntologyBiologicalProcessleft/right pattern formation

IFT140 PKD1L1 LEFTY2 LEFTY1 NPHP3 PCSK6 NOTCH2 DNAH11

6.60e-051621728GO:0060972
GeneOntologyBiologicalProcesscell-cell adhesion via plasma-membrane adhesion molecules

FAT4 FAT3 ITGA5 DSCAML1 CELSR1 HMCN2 PTPRF DCHS1 NECTIN4 CX3CL1 CDH5

6.66e-0531317211GO:0098742
GeneOntologyBiologicalProcessnodal receptor complex assembly

LEFTY2 LEFTY1

6.91e-0521722GO:0038099
GeneOntologyBiologicalProcessnegative regulation of nodal receptor complex assembly

LEFTY2 LEFTY1

6.91e-0521722GO:1900124
GeneOntologyBiologicalProcessregulation of nodal receptor complex assembly

LEFTY2 LEFTY1

6.91e-0521722GO:1900123
GeneOntologyBiologicalProcessdetermination of bilateral symmetry

IFT140 PKD1L1 LEFTY2 LEFTY1 NPHP3 PCSK6 NOTCH2 DNAH11

7.51e-051651728GO:0009855
GeneOntologyBiologicalProcessspecification of symmetry

IFT140 PKD1L1 LEFTY2 LEFTY1 NPHP3 PCSK6 NOTCH2 DNAH11

7.51e-051651728GO:0009799
GeneOntologyBiologicalProcessnegative regulation of protein-containing complex assembly

CARD8 LEFTY2 LMOD3 LEFTY1 SVIL ARHGEF2 CDH5 SORL1

1.04e-041731728GO:0031333
GeneOntologyBiologicalProcessheart valve morphogenesis

AXIN2 BMPR2 DCHS1 NOS3 NOTCH2

1.81e-04631725GO:0003179
GeneOntologyBiologicalProcessmitral valve morphogenesis

AXIN2 BMPR2 DCHS1

2.41e-04151723GO:0003183
GeneOntologyBiologicalProcessmitral valve development

AXIN2 BMPR2 DCHS1

2.95e-04161723GO:0003174
MousePhenoabnormal somite development

IFT140 SUPT20H FN1 ITGA5 F5 DDX11 LEFTY2 TBX18 LEFTY1 MTHFD1 VCAN CDH5

2.71e-0622214212MP:0001688
MousePhenoabnormal left-right axis patterning

SUPT20H PKD1L1 LEFTY2 LEFTY1 NPHP3 PCSK6 DNAH11

5.03e-06671427MP:0001706
MousePhenoimpaired somite development

SUPT20H FN1 ITGA5 DDX11 LEFTY2 LEFTY1 MTHFD1 CDH5

1.05e-051041428MP:0009768
MousePhenoabnormal interatrial septum morphology

FAT4 LEFTY2 LEFTY1 PCSK6 DCHS1 NOS3 PCNT DNAH11

1.30e-051071428MP:0000282
MousePhenoleft pulmonary isomerism

IFT140 LEFTY2 LEFTY1 PCSK6 DNAH11

1.38e-05311425MP:0003178
MousePhenoabnormal cardiovascular development

STARD13 IFT140 SUPT20H FN1 APC CHD4 CUL7 ITGA5 AXIN2 DDX11 LEFTY2 TBX18 LEFTY1 BMPR2 ARAP3 VCAN PCSK6 AKAP13 MED23 CDH5 NOS3 PCNT

1.88e-0580214222MP:0002925
MousePhenoleft-sided isomerism

IFT140 LEFTY2 LEFTY1 PCSK6 DNAH11

2.21e-05341425MP:0000542
MousePhenoabnormal lung position or orientation

IFT140 PKD1L1 LEFTY2 LEFTY1 PCSK6 DNAH11

2.34e-05571426MP:0010853
MousePhenoabnormal orientation of cochlear hair cell stereociliary bundles

FAT4 BBS1 CELSR1 OSBPL2 DCHS1

2.56e-05351425MP:0004522
MousePhenoabnormal placenta development

SUPT20H FN1 CUL7 TRIP12 PGR DDX11 LEFTY2 DAP3 LEFTY1

3.67e-051601429MP:0001712
MousePhenoleft atrial isomerism

LEFTY2 LEFTY1 DNAH11

5.54e-0581423MP:0008461
MousePhenoprenatal growth retardation

IFT140 GAPVD1 SUPT20H FN1 PKD1L1 CUL7 ITGA5 PIR TRIP12 KIAA0753 DDX11 BMPR2 MTHFD1 VCAN DDX18 AKAP13 MED23 CDH5 NOS3 NOTCH2 PCNT SMG6

6.33e-0586914222MP:0010865
MousePhenoabsent somites

FN1 DDX11 LEFTY2 LEFTY1 MTHFD1

6.34e-05421425MP:0006386
MousePhenoabnormal cardiac outflow tract development

IFT140 FN1 LEFTY2 LEFTY1 BMPR2 VCAN PCSK6 CDH5

6.61e-051341428MP:0006126
MousePhenoembryonic lethality during organogenesis

IFT140 FN1 PITRM1 APC BBS1 ITGA5 TRIP12 F5 AXIN2 DDX11 LEFTY2 DAP3 LEFTY1 BMPR2 ARAP3 MTHFD1 VCAN AKAP13 MED23 ARMH3 CDH5 NOTCH2

7.13e-0587614222MP:0006207
MousePhenoaccessory spleen

LEFTY2 LEFTY1 DNAH11

8.24e-0591423MP:0003342
MousePhenodecreased kidney cell proliferation

FAT4 NOS3 NOTCH2

8.24e-0591423MP:0011441
MousePhenoembryonic lethality during organogenesis, complete penetrance

IFT140 FN1 PITRM1 APC ITGA5 TRIP12 DDX11 LEFTY2 DAP3 LEFTY1 BMPR2 ARAP3 MTHFD1 VCAN AKAP13 MED23 ARMH3 CDH5 NOTCH2

8.51e-0570014219MP:0011098
MousePhenoabnormal lung morphology

IFT140 NEU4 FAT4 POLE PKD1L1 CUL9 LYST PIKFYVE LEFTY2 LEFTY1 BMPR2 CELSR1 GYG1 PCSK6 DCHS1 SIGLEC1 NOS3 PCNT DNAH11 SLC23A3

9.47e-0576714220MP:0001175
MousePhenoabnormal embryo development

GAPVD1 SUPT20H FN1 PKD1L1 APC ITGA5 PIR TRIP12 AXIN2 KIAA0753 DDX11 PIKFYVE LEFTY2 DAP3 LEFTY1 BMPR2 NPHP3 ARAP3 MTHFD1 VCAN PCSK6 DDX18 AKAP13 MED23 CDH5 NOTCH2 PCNT SMG6 DNAH11

1.00e-04137014229MP:0001672
MousePhenoabnormal left renal vein morphology

LEFTY2 LEFTY1

1.02e-0421422MP:0011327
MousePhenoabnormal renal vein morphology

LEFTY2 LEFTY1

1.02e-0421422MP:0011323
MousePhenoabnormal right lung morphology

IFT140 LEFTY2 LEFTY1 PCSK6 DNAH11

1.10e-04471425MP:0009570
MousePhenoabnormal heart atrium morphology

FAT4 PIKFYVE LEFTY2 LEFTY1 VCAN PCSK6 DCHS1 NOS3 PCNT DNAH11

1.28e-0423214210MP:0003105
MousePhenofailure of somite differentiation

FN1 DDX11 LEFTY2 LEFTY1 MTHFD1

1.48e-04501425MP:0001690
MousePhenodextrocardia

PKD1L1 LEFTY2 LEFTY1 PCSK6 DNAH11

1.63e-04511425MP:0000644
MousePhenoabnormal extraembryonic tissue physiology

SUPT20H FN1 CHD4 CUL7 ITGA5 TRIP12 PGR DDX11 LEFTY2 DAP3 LEFTY1 ARAP3

2.07e-0434514212MP:0004264
MousePhenoatrioventricular septal defect

IFT140 LEFTY2 LEFTY1 BMPR2 PCNT DNAH11

2.10e-04841426MP:0010412
MousePhenoabnormal embryonic growth/weight/body size

GAPVD1 SUPT20H FN1 PKD1L1 APC CUL7 ITGA5 PIR TRIP12 AXIN2 KIAA0753 DDX11 PIKFYVE DAP3 BMPR2 PIEZO2 ARAP3 PNPLA1 MTHFD1 VCAN DDX18 AKAP13 MED23 CDH5 NOTCH2 PCNT SMG6

2.33e-04129514227MP:0002088
MousePhenoabnormal placenta physiology

SUPT20H FN1 CUL7 TRIP12 PGR DDX11 LEFTY2 DAP3 LEFTY1

2.36e-042041429MP:0010038
MousePhenoabnormal embryo turning

SUPT20H FN1 PKD1L1 APC ITGA5 KIAA0753 DAP3 NPHP3 VCAN CDH5

2.43e-0425114210MP:0001700
MousePhenoabnormal atrioventricular septum morphology

IFT140 LEFTY2 LEFTY1 BMPR2 PCNT DNAH11

2.54e-04871426MP:0010592
MousePhenoembryonic growth retardation

GAPVD1 SUPT20H FN1 PKD1L1 ITGA5 PIR TRIP12 KIAA0753 DDX11 BMPR2 MTHFD1 VCAN DDX18 AKAP13 MED23 CDH5 NOTCH2 PCNT SMG6

2.59e-0476314219MP:0003984
MousePhenoatrial septal defect

LEFTY2 LEFTY1 PCSK6 NOS3 PCNT DNAH11

2.70e-04881426MP:0010403
MousePhenocurly tail

IFT140 FAT4 AXIN2 CELSR1 DCHS1

2.76e-04571425MP:0003051
MousePhenoabnormal kidney venous blood vessel morphology

LEFTY2 LEFTY1

3.05e-0431422MP:0011311
MousePhenoheterotaxia

IFT140 PKD1L1 LEFTY2 LEFTY1 PCSK6 DNAH11

3.05e-04901426MP:0004133
MousePhenoabnormal extraembryonic tissue morphology

SUPT20H FN1 PITRM1 BBS1 CUL7 ITGA5 TRIP12 F5 DDX11 PIKFYVE LEFTY2 DAP3 LEFTY1 BMPR2 CELSR1 ARAP3 VCAN MED23 ARMH3 CDH5 NOTCH2

3.29e-0490814221MP:0002086
MousePhenoabnormal embryonic tissue morphology

IFT140 FAT4 SUPT20H FN1 APC ITGA5 F5 AXIN2 DDX11 LEFTY2 TBX18 LEFTY1 BMPR2 CELSR1 MTHFD1 VCAN PCSK6 DDX18 DCHS1 AKAP13 MED23 CDH5 PCNT DNAH11

3.49e-04111614224MP:0002085
MousePhenoabnormal vascular development

STARD13 SUPT20H FN1 CUL7 ITGA5 LEFTY2 TBX18 LEFTY1 BMPR2 ARAP3 VCAN MED23 CDH5 NOS3 PCNT

4.06e-0454214215MP:0000259
MousePhenoabnormal prenatal growth/weight/body size

IFT140 GAPVD1 SUPT20H FN1 PKD1L1 APC CUL7 ITGA5 PIR TRIP12 AXIN2 KIAA0753 DDX11 PIKFYVE DAP3 BMPR2 PIEZO2 ARAP3 PNPLA1 MTHFD1 VCAN DDX18 AKAP13 MED23 CDH5 NOS3 NOTCH2 PCNT SMG6

4.37e-04149314229MP:0004196
MousePhenoabnormal hepatic portal vein morphology

LEFTY2 LEFTY1 DNAH11

5.22e-04161423MP:0010668
MousePhenofailure of chorioallantoic fusion

SUPT20H FN1 DDX11 LEFTY2 LEFTY1

5.87e-04671425MP:0009657
MousePhenoabsent vitelline blood vessels

FN1 LEFTY2 LEFTY1 BMPR2 CDH5

5.87e-04671425MP:0001719
MousePhenoabnormal heart septum morphology

IFT140 FAT4 CHD4 LEFTY2 LEFTY1 BMPR2 VCAN PCSK6 DCHS1 NOS3 PCNT DNAH11

5.98e-0438814212MP:0006113
MousePhenoabnormal cardiac jelly morphology

FN1 CHD4

6.07e-0441422MP:0009382
MousePhenoabnormal large intestine placement

LEFTY2 LEFTY1

6.07e-0441422MP:0003284
MousePhenoabnormal heart atrium arrangement

LEFTY2 LEFTY1 DNAH11

6.29e-04171423MP:0014319
MousePhenoabnormal vitelline vasculature morphology

SUPT20H FN1 ITGA5 LEFTY2 LEFTY1 BMPR2 ARAP3 VCAN CDH5

6.62e-042351429MP:0003229
MousePhenoabnormal atrioventricular valve morphology

IFT140 LEFTY2 LEFTY1 DCHS1 DNAH11

6.72e-04691425MP:0002745
MousePhenoabnormal developmental patterning

SUPT20H FN1 PKD1L1 APC ITGA5 KIAA0753 LEFTY2 DAP3 LEFTY1 BMPR2 NPHP3 VCAN PCSK6 CDH5 DNAH11

7.75e-0457714215MP:0002084
MousePhenoabsent notochord

FN1 LEFTY2 LEFTY1

8.83e-04191423MP:0000932
MousePhenoabnormal placenta morphology

FN1 PITRM1 BBS1 CUL7 TRIP12 DDX11 DAP3 CELSR1 ARAP3 VCAN MED23 ARMH3 CDH5 NOTCH2

9.13e-0452514214MP:0001711
MousePhenoabnormal heart position or orientation

PKD1L1 LEFTY2 LEFTY1 PCSK6 DNAH11

9.25e-04741425MP:0006065
MousePhenoembryonic lethality, incomplete penetrance

FN1 APC BBS1 F5 AXIN2 PIKFYVE LEFTY2 LEFTY1 BMPR2 VCAN CDH5 SMG6

9.68e-0441014212MP:0011102
MousePhenoprenatal lethality prior to heart atrial septation, incomplete penetrance

FN1 APC BBS1 F5 AXIN2 PIKFYVE LEFTY2 LEFTY1 BMPR2 VCAN CDH5 SMG6

9.68e-0441014212MP:0031660
MousePhenoabnormal gastrulation

SUPT20H FN1 PKD1L1 APC ITGA5 KIAA0753 LEFTY2 DAP3 LEFTY1 BMPR2 NPHP3 VCAN CDH5

9.83e-0446914213MP:0001695
MousePhenoabnormal heart atrium and ventricle connection

IFT140 LEFTY2 LEFTY1 DCHS1 DNAH11

9.83e-04751425MP:0010435
MousePhenoabnormal pulmonary vascular resistance

BMPR2 NOS3

1.00e-0351422MP:0003033
MousePhenoenlarged endometrial glands

PGR CDH5

1.00e-0351422MP:0009251
MousePhenowide sternum

FAT4 DCHS1

1.00e-0351422MP:0012279
MousePhenoincomplete somite formation

SUPT20H FN1 ITGA5 CDH5

1.01e-03441424MP:0001689
MousePhenoabnormal primary cilium morphology

IFT140 BBS1 CELSR1 NPHP3 OSBPL2 DNAH11

1.07e-031141426MP:0013203
DomainCul7

CUL9 CUL7 HERC2

7.15e-0731683PF11515
DomainCPH_domain

CUL9 CUL7 HERC2

7.15e-0731683IPR021097
DomainRib_L2_dom2

CUL9 CUL7 HERC2 MRPL24

1.75e-05181684IPR014722
Domain-

CUL9 CUL7 HERC2 MRPL24

1.75e-051816842.30.30.30
DomainAPC_su10/DOC_dom

CUL9 CUL7 HERC2

2.44e-0571683IPR004939
DomainDOC

CUL9 CUL7 HERC2

2.44e-0571683PS51284
DomainANAPC10

CUL9 CUL7 HERC2

2.44e-0571683PF03256
DomainAPC10

CUL9 CUL7 HERC2

2.44e-0571683SM01337
DomainASX_HYDROXYL

FAT4 FAT3 CELSR1 OIT3 HMCN2 VCAN NOTCH2

3.33e-051001687PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

FAT4 FAT3 CELSR1 OIT3 HMCN2 VCAN NOTCH2

4.85e-051061687IPR000152
Domain-

CUL9 CUL7 BTBD9 F5 PCSK6 HERC2

5.01e-057316862.60.120.260
DomainLRDF

LEFTY2 LEFTY1

8.04e-0521682IPR003942
DomainEGF-like_dom

FAT4 FAT3 CELSR1 OIT3 HMCN2 VCAN PCSK6 ASTN1 NOTCH2 SORL1

8.82e-0524916810IPR000742
DomainEGF_CA

FAT4 FAT3 CELSR1 OIT3 HMCN2 VCAN NOTCH2

1.18e-041221687SM00179
DomainEGF-like_Ca-bd_dom

FAT4 FAT3 CELSR1 OIT3 HMCN2 VCAN NOTCH2

1.31e-041241687IPR001881
DomainGalactose-bd-like

CUL9 CUL7 BTBD9 F5 PCSK6 HERC2

2.05e-04941686IPR008979
DomainVPS13

VPS13C VPS13D

2.40e-0431682IPR026847
DomainVPS13_mid_rpt

VPS13C VPS13D

2.40e-0431682PF16910
DomainVPS13

VPS13C VPS13D

2.40e-0431682PF16908
DomainVPS13_N2

VPS13C VPS13D

2.40e-0431682IPR031646
DomainVPS13_mid_rpt

VPS13C VPS13D

2.40e-0431682IPR031642
DomainEGF_Ca-bd_CS

FAT4 FAT3 OIT3 HMCN2 VCAN NOTCH2

2.44e-04971686IPR018097
DomainEGF_CA

FAT4 FAT3 OIT3 HMCN2 VCAN NOTCH2

2.72e-04991686PS01187
DomainEGF

FAT4 FAT3 CELSR1 OIT3 VCAN PCSK6 ASTN1 NOTCH2 SORL1

2.84e-042351689SM00181
DomainEGF_3

FAT4 FAT3 CELSR1 OIT3 HMCN2 VCAN ASTN1 NOTCH2 SORL1

2.84e-042351689PS50026
DomainSHR-BD

VPS13C VPS13D

4.77e-0441682IPR009543
DomainVPS13_C

VPS13C VPS13D

4.77e-0441682PF16909
DomainVPS13_C

VPS13C VPS13D

4.77e-0441682IPR031645
DomainSHR-BD

VPS13C VPS13D

4.77e-0441682PF06650
DomainEGF_1

FAT4 FN1 FAT3 CELSR1 OIT3 HMCN2 VCAN ASTN1 NOTCH2

5.14e-042551689PS00022
DomainEGF-like_CS

FAT4 FN1 FAT3 CELSR1 HMCN2 VCAN ASTN1 NOTCH2 SORL1

6.08e-042611689IPR013032
DomainCadherin-like

FAT4 SGCA FAT3 CELSR1 DCHS1 CDH5

6.36e-041161686IPR015919
DomainEGF_2

FAT4 FAT3 CELSR1 OIT3 HMCN2 VCAN ASTN1 NOTCH2 SORL1

6.77e-042651689PS01186
DomainRasGEFN

RASGEF1A KNDC1 SOS2

7.28e-04201683SM00229
Domain-

POLE PIWIL2 ISG20 PAN2

8.33e-044716843.30.420.10
DomainRasGEF_N

RASGEF1A KNDC1 SOS2

8.44e-04211683PF00618
DomainRas-like_Gua-exchang_fac_N

RASGEF1A KNDC1 SOS2

9.71e-04221683IPR000651
DomainRASGEF_NTER

RASGEF1A KNDC1 SOS2

9.71e-04221683PS50212
DomainRASGEF

RASGEF1A KNDC1 SOS2

1.60e-03261683PS00720
DomainIg-like_fold

SIGLEC12 FN1 SGCA IL22RA1 DSCAML1 HMCN2 PTPRF NFATC2 SIGLEC6 VCAN NECTIN4 ASTN1 SIGLEC1 EPB42 SORL1

1.81e-0370616815IPR013783
DomainChorein_N

VPS13C VPS13D

2.17e-0381682PF12624
DomainCullin_neddylation_domain

CUL9 CUL7

2.17e-0381682IPR019559
DomainCullin_Nedd8

CUL9 CUL7

2.17e-0381682PF10557
DomainVPS13_N

VPS13C VPS13D

2.17e-0381682IPR026854
DomainCullin_Nedd8

CUL9 CUL7

2.17e-0381682SM00884
DomainRASGEF_CAT

RASGEF1A KNDC1 SOS2

2.20e-03291683PS50009
DomainRasGEF

RASGEF1A KNDC1 SOS2

2.43e-03301683PF00617
Domain-

RASGEF1A KNDC1 SOS2

2.43e-033016831.10.840.10
DomainRASGEF_cat_dom

RASGEF1A KNDC1 SOS2

2.43e-03301683IPR001895
DomainRasGEF

RASGEF1A KNDC1 SOS2

2.43e-03301683SM00147
DomainRas_GEF_dom

RASGEF1A KNDC1 SOS2

2.43e-03301683IPR023578
DomainDH_1

PREX2 AKAP13 ARHGEF2 SOS2

2.49e-03631684PS00741
Domain-

SIGLEC12 FN1 SGCA IL22RA1 DSCAML1 PTPRF NFATC2 SIGLEC6 VCAN NECTIN4 ASTN1 SIGLEC1 EPB42 SORL1

2.71e-03663168142.60.40.10
DomainCullin_homology

CUL9 CUL7

2.78e-0391682IPR016158
DomainSialidases

NEU4 SORL1

2.78e-0391682IPR011040
DomainTGF-beta-rel

INHA LEFTY2 LEFTY1

2.93e-03321683IPR015615
DomainTGFb_CS

INHA LEFTY2 LEFTY1

2.93e-03321683IPR017948
DomainCadherin_CS

FAT4 FAT3 CELSR1 DCHS1 CDH5

3.05e-031091685IPR020894
DomainRhoGEF

PREX2 AKAP13 ARHGEF2 SOS2

3.29e-03681684SM00325
DomainCullin

CUL9 CUL7

3.45e-03101682PF00888
DomainPTrfase/Anion_transptr

SLC4A3 SLC4A11

3.45e-03101682IPR016152
DomainHCO3_transpt_euk

SLC4A3 SLC4A11

3.45e-03101682IPR003020
DomainHCO3_cotransp

SLC4A3 SLC4A11

3.45e-03101682PF00955
DomainHCO3_transpt_C

SLC4A3 SLC4A11

3.45e-03101682IPR011531
DomainCULLIN_2

CUL9 CUL7

3.45e-03101682PS50069
DomainCullin_N

CUL9 CUL7

3.45e-03101682IPR001373
DomainCULLIN_1

CUL9 CUL7

3.45e-03101682PS01256
DomainRNaseH-like_dom

POLE PIWIL2 ISG20 PAN2

3.47e-03691684IPR012337
DomainCADHERIN_1

FAT4 FAT3 CELSR1 DCHS1 CDH5

3.57e-031131685PS00232
DomainCadherin

FAT4 FAT3 CELSR1 DCHS1 CDH5

3.57e-031131685PF00028
DomainRhoGEF

PREX2 AKAP13 ARHGEF2 SOS2

3.65e-03701684PF00621
DomainDH_2

PREX2 AKAP13 ARHGEF2 SOS2

3.65e-03701684PS50010
DomainCADHERIN_2

FAT4 FAT3 CELSR1 DCHS1 CDH5

3.70e-031141685PS50268
Domain-

FAT4 FAT3 CELSR1 DCHS1 CDH5

3.70e-0311416852.60.40.60
Domain-

PREX2 AKAP13 ARHGEF2 SOS2

3.84e-037116841.20.900.10
DomainDH-domain

PREX2 AKAP13 ARHGEF2 SOS2

3.84e-03711684IPR000219
DomainCA

FAT4 FAT3 CELSR1 DCHS1 CDH5

3.84e-031151685SM00112
DomainCadherin

FAT4 FAT3 CELSR1 DCHS1 CDH5

4.29e-031181685IPR002126
DomainTGF-b_C

INHA LEFTY2 LEFTY1

4.44e-03371683IPR001839
DomainTGF_BETA_1

INHA LEFTY2 LEFTY1

4.44e-03371683PS00250
DomainTGFB

INHA LEFTY2 LEFTY1

4.44e-03371683SM00204
DomainTGF_BETA_2

INHA LEFTY2 LEFTY1

4.44e-03371683PS51362
DomainTGF_beta

INHA LEFTY2 LEFTY1

4.44e-03371683PF00019
DomainLAM_G_DOMAIN

FAT4 FAT3 CELSR1

4.79e-03381683PS50025
DomainGDS_CDC24_CS

PREX2 ARHGEF2 SOS2

5.15e-03391683IPR001331
DomainIGc2

SIGLEC12 DSCAML1 HMCN2 PTPRF SIGLEC6 NECTIN4 SIGLEC1

5.46e-032351687SM00408
DomainIg_sub2

SIGLEC12 DSCAML1 HMCN2 PTPRF SIGLEC6 NECTIN4 SIGLEC1

5.46e-032351687IPR003598
DomainLaminin_G_2

FAT4 FAT3 CELSR1

5.53e-03401683PF02210
DomainC2-set_2

SIGLEC12 NECTIN4 SIGLEC1

5.93e-03411683PF08205
DomainCD80_C2-set

SIGLEC12 NECTIN4 SIGLEC1

5.93e-03411683IPR013162
DomainSAM_2

STARD13 STIM2 ARAP3

6.78e-03431683PF07647
DomainDynein_heavy_chain_D4_dom

DNAH14 DNAH11

6.82e-03141682IPR024317
DomainDynein_HC_stalk

DNAH14 DNAH11

6.82e-03141682IPR024743
DomainEXOIII

ISG20 PAN2

6.82e-03141682SM00479
DomainExonuclease_RNaseT/DNA_pol3

ISG20 PAN2

6.82e-03141682IPR013520
DomainRNase_T

ISG20 PAN2

6.82e-03141682PF00929
DomainMT

DNAH14 DNAH11

6.82e-03141682PF12777
DomainAAA_8

DNAH14 DNAH11

6.82e-03141682PF12780
DomainLamG

FAT4 FAT3 CELSR1

7.23e-03441683SM00282
DomainIg_I-set

SIGLEC12 DSCAML1 HMCN2 PTPRF SIGLEC6 SIGLEC1

7.52e-031901686IPR013098
Pubmed

Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report.

FAT4 FN1 CELSR1 DCHS1 CDH5

3.67e-109174528705793
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

GAPVD1 STIM2 HIPK4 IQSEC2 MINK1 APC ARHGAP17 TRIP12 LYST CARD8 MYLK2 KIAA0753 MLXIPL VPS13D BMPR2 SIPA1L1 SVIL AKAP13 ARHGEF2 NOTCH2

1.43e-088611742036931259
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

IFT140 CUL9 CUL7 TRIP12 DSCAML1 VPS13D SIPA1L1 MED23 TSPYL4

2.09e-08130174912421765
Pubmed

Generation of robust left-right asymmetry in the mouse embryo requires a self-enhancement and lateral-inhibition system.

LEFTY2 LEFTY1 DNAH11

1.23e-073174317011489
Pubmed

Genetic Analysis Reveals a Hierarchy of Interactions between Polycystin-Encoding Genes and Genes Controlling Cilia Function during Left-Right Determination.

PKD1L1 LEFTY2 LEFTY1 DNAH11

1.94e-0711174427272319
Pubmed

The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.

LEFTY2 LEFTY1 NPHP3 DNAH11

4.18e-0713174417884984
Pubmed

Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos.

LEFTY2 LEFTY1 DNAH11

4.91e-07417439348041
Pubmed

Distinct transcriptional regulatory mechanisms underlie left-right asymmetric expression of lefty-1 and lefty-2.

LEFTY2 LEFTY1 DNAH11

4.91e-07417439990851
Pubmed

Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry.

LEFTY2 LEFTY1 DNAH11

4.91e-07417439708732
Pubmed

Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos.

LEFTY2 LEFTY1 DNAH11

4.91e-07417438610011
Pubmed

Essential roles of fibronectin in the development of the left-right embryonic body plan.

FN1 ITGA5 LEFTY2 LEFTY1

7.91e-0715174421466802
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

AMBN IFT140 SUPT20H FAT3 CUL9 CHD4 CUL7 ACY1 DCAF5 DAP3 HMCN2 SIPA1L1 PCSK6 DDX18 SIGLEC1 ZNF281 NOTCH2 SLC4A11 SORL1 WDR72

9.04e-0711161742031753913
Pubmed

Determination of left/right asymmetric expression of nodal by a left side-specific enhancer with sequence similarity to a lefty-2 enhancer.

LEFTY2 LEFTY1 DNAH11

1.22e-065174310385627
Pubmed

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.

FARSB CUL9 CUL7 TRIP12 MOXD1 SIPA1L1 PAN2 HERC2 PCNT

1.34e-06212174933853758
Pubmed

Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1.

LEFTY2 LEFTY1 NPHP3 DNAH11

1.37e-0617174422357932
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

STRBP POLE FARSB CHD4 CUL7 OGDH TRIP12 NOP14 DDX18 KCTD20 BOP1 HERC2 ARHGEF2 MED23 ZC3H7B CNOT1

1.53e-067591741635915203
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

FAT4 GAPVD1 STIM2 FN1 VPS13C MINK1 APC MUC16 CHD4 TRIP12 DMXL1 EPS15L1 OSBPL2 MTHFD1 DDX18 NOTCH2

2.07e-067771741635844135
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

GAPVD1 TBC1D15 SUPT20H IQSEC2 TOM1 APC ACAD10 DSCAML1 DCAF5 KIAA0753 DAP3 EPS15L1 SVIL AKAP13 DNAH11

2.23e-066891741536543142
Pubmed

Genetic risk factors for placental abruption: a HuGE review and meta-analysis.

F5 MTHFD1 NOS3

2.43e-066174318277167
Pubmed

Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2.

LEFTY2 LEFTY1 DNAH11

2.43e-066174310678167
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

POLE CUL9 ARHGAP17 KTI12 ITGA5 LYST PIKFYVE EPS15L1 CELSR1 ARAP3 PTPRF AKAP13 HERC2 ARHGEF2 ZC3H7B NOTCH2 PCNT SMG6 RASD2

3.14e-0611051741935748872
Pubmed

Wnt3a links left-right determination with segmentation and anteroposterior axis elongation.

AXIN2 LEFTY2 LEFTY1 DNAH11

3.39e-0621174416291790
Pubmed

Molecular mechanisms of vertebrate left-right development.

LEFTY2 LEFTY1 DNAH11

4.24e-06717439825674
Pubmed

Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.

FAT4 FAT3 DCHS1

4.24e-067174316059920
Pubmed

Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.

APC AXIN2 LEFTY2 LEFTY1

4.98e-0623174414623818
Pubmed

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.

STRBP POLE KIAA0753 DDX11 PIKFYVE SIPA1L1 BOP1 ARHGEF2 CNOT1

5.34e-06251174929778605
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

AMFR FN1 STRBP APC FARSB ACAD10 F5 PREX2 DMXL1 SIPA1L1 BOP1 HERC2

5.44e-064751741231040226
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

GAPVD1 FN1 STRBP POLE CUL9 CHD4 CUL7 TRIP12 NOP14 DDX18 BOP1 HERC2 CNOT1 PCNT

5.86e-066531741422586326
Pubmed

Rac1 mediates morphogenetic responses to intercellular signals in the gastrulating mouse embryo.

FN1 ITGA5 LEFTY2 LEFTY1

5.95e-0624174421693517
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

TBC1D15 STIM2 PITRM1 VPS13C POLE NUF2 CUL7 OGDH MRPL35 PIKFYVE DAP3 VPS13D NOP14 DDX18 BOP1 HERC2 ARHGEF2 MRPL24 EIF2AK3 QRSL1 PCNT SMG6

6.24e-0614961742232877691
Pubmed

USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c.

TRIP12 NOP14 MTHFD1 DDX18 ZNF281 NOTCH2

6.32e-0690174635654790
Pubmed

Notch signaling regulates left-right asymmetry determination by inducing Nodal expression.

LEFTY2 LEFTY1 NOTCH2

6.77e-068174312730124
Pubmed

Two nodal-responsive enhancers control left-right asymmetric expression of Nodal.

LEFTY2 LEFTY1 DNAH11

6.77e-068174315736223
Pubmed

Crosstalk between Nodal/activin and MAPK p38 signaling is essential for anterior-posterior axis specification.

SUPT20H LEFTY2 LEFTY1

6.77e-068174321802298
Pubmed

PIERCE1 is critical for specification of left-right asymmetry in mice.

LEFTY2 LEFTY1 DNAH11

6.77e-068174327305836
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

GAPVD1 STRBP POLE FARSB CUL9 CHD4 CUL7 TRIP12 NOP14 NFATC2 ARHGEF2 NHEJ1 MRPL24 EIF2AK3 NOTCH2 SORL1

7.15e-068571741625609649
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SUPT20H FN1 IQSEC2 APC CUL9 CHD4 TRIP12 SLC4A3 OLR1 DSCAML1 DCAF5 EPS15L1 RPRD1A SIPA1L1 PCSK6 DDX18 ASTN1 HERC2 PCNT SOS2

7.50e-0612851742035914814
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

TBC1D15 STIM2 VPS13C TOM1 ITGA5 LYST DMXL1 PIKFYVE VPS13D HEATR5B EIF2AK3 NOTCH2

9.86e-065041741234432599
Pubmed

Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.

PKD1L1 LEFTY2 LEFTY1

1.01e-059174321307093
Pubmed

SPC4/PACE4 regulates a TGFbeta signaling network during axis formation.

LEFTY2 LEFTY1 PCSK6

1.44e-0510174310809672
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

GAPVD1 APC CHD4 TRIP12 RPRD1A DDX18 BOP1 HERC2 ARHGEF2 MED23 EIF2AK3

1.49e-054401741134244565
Pubmed

Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling.

AXIN2 LEFTY2 LEFTY1 ZNF281

1.50e-0530174429168693
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

GAPVD1 TBC1D15 STRBP CHD4 CUL7 TRIP12 F5 PTPRF MTHFD1 DDX18 SVIL BOP1 HERC2 ARHGEF2 HEATR5B CNOT1 PCNT

1.67e-0510241741724711643
Pubmed

The NuRD chromatin-remodeling enzyme CHD4 promotes embryonic vascular integrity by transcriptionally regulating extracellular matrix proteolysis.

FN1 CHD4 CDH5

1.97e-0511174324348274
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

FAT4 GAPVD1 FN1 VPS13C IQSEC2 PIWIL2 TRIP12 DSCAML1 ESCO1 DNAH14 MTHFD1 AKAP13 CNOT1 BANK1

2.22e-057361741429676528
Pubmed

TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease.

VPS13C TRIP12 MYLK2 VPS13D SVIL

2.22e-0567174534644545
Pubmed

Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.

FAT4 FAT3 CELSR1 PTPRF DCHS1

2.22e-0567174521875946
Pubmed

Tie2 regulates endocardial sprouting and myocardial trabeculation.

FN1 ARAP3 VCAN CDH5 NOS3

2.39e-0568174531112136
Pubmed

A mouse model for endometrioid ovarian cancer arising from the distal oviduct.

APC PGR

2.49e-052174224474556
Pubmed

Role of LOX-1 in monocyte adhesion-triggered redox, Akt/eNOS and Ca2+ signaling pathways in endothelial cells.

OLR1 NOS3

2.49e-052174219452449
Pubmed

Versican provides the provisional matrix for uterine spiral artery dilation and fetal growth.

PGR VCAN

2.49e-052174236423736
Pubmed

Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion.

APC AXIN2

2.49e-052174221982234
Pubmed

LEFTY, a member of the transforming growth factor-beta superfamily, inhibits uterine stromal cell differentiation: a novel autocrine role.

LEFTY2 LEFTY1

2.49e-052174220056823
Pubmed

Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development.

LEFTY2 LEFTY1

2.49e-052174210053005
Pubmed

Mutation analysis of human LEFTY A and LEFTY B genes in children with Ivemark syndrome.

LEFTY2 LEFTY1

2.49e-052174211100524
Pubmed

PERK inhibition attenuates vascular remodeling in pulmonary arterial hypertension caused by BMPR2 mutation.

BMPR2 EIF2AK3

2.49e-052174233500333
Pubmed

A heart segmental defect in the anterior-posterior axis of a transgenic mutant mouse.

FN1 VCAN

2.49e-05217429188753
Pubmed

Clinical and molecular features of attenuated adenomatous polyposis in northern Italy.

APC MUTYH

2.49e-052174222976915
Pubmed

Defining the topology of integrin alpha5beta1-fibronectin interactions using inhibitory anti-alpha5 and anti-beta1 monoclonal antibodies. Evidence that the synergy sequence of fibronectin is recognized by the amino-terminal repeats of the alpha5 subunit.

FN1 ITGA5

2.49e-05217429211865
Pubmed

Overlapping and independent functions of fibronectin receptor integrins in early mesodermal development.

FN1 ITGA5

2.49e-052174210545236
Pubmed

Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors.

APC AXIN2

2.49e-052174211809809
Pubmed

Identification of rare missense mutations in NOTCH2 and HERC2 associated with familial central precocious puberty via whole-exome sequencing.

HERC2 NOTCH2

2.49e-052174232400230
Pubmed

Molecular basis of familial adenomatous polyposis in the southeast of Brazil: identification of six novel mutations.

APC MUTYH

2.49e-052174230852976
Pubmed

Mthfd1 is a modifier of chemically induced intestinal carcinogenesis.

APC MTHFD1

2.49e-052174221156972
Pubmed

Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice.

APC MUTYH

2.49e-052174215604247
Pubmed

Correlation between mutations and mRNA expression of APC and MUTYH genes: new insight into hereditary colorectal polyposis predisposition.

APC MUTYH

2.49e-052174226511139
Pubmed

[G894T (NOS3) and G1958A (MTHFD1) gene polymorphisms and risk of ischemic heart disease in Yucatan, Mexico].

MTHFD1 NOS3

2.49e-052174225304051
Pubmed

Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin-Independent Targets by Proteomics.

MINK1 APC

2.49e-052174231160382
Pubmed

APC or MUTYH mutations account for the majority of clinically well-characterized families with FAP and AFAP phenotype and patients with more than 30 adenomas.

APC MUTYH

2.49e-052174219793053
Pubmed

Versican V2 isoform enhances angiogenesis by regulating endothelial cell activities and fibronectin expression.

FN1 VCAN

2.49e-052174223201264
Pubmed

Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways.

LEFTY2 LEFTY1

2.49e-052174233409963
Pubmed

Cell adhesion. Fibronectin and integrin knockouts come unstuck.

FN1 ITGA5

2.49e-05217427522915
Pubmed

Endothelial damage in white coat hypertension: role of lectin-like oxidized low-density lipoprotein-1.

OLR1 NOS3

2.49e-052174225007999
Pubmed

Molecular analysis of LEFTY-expressing cells in early human embryoid bodies.

LEFTY2 LEFTY1

2.49e-052174217038673
Pubmed

Mutation analysis of the MYH gene in an Australian series of colorectal polyposis patients with or without germline APC mutations.

APC MUTYH

2.49e-052174215761860
Pubmed

Native Piezo2 Interactomics Identifies Pericentrin as a Novel Regulator of Piezo2 in Somatosensory Neurons.

PIEZO2 PCNT

2.49e-052174227345391
Pubmed

Low frequency of AXIN2 mutations and high frequency of MUTYH mutations in patients with multiple polyposis.

AXIN2 MUTYH

2.49e-052174216941501
Pubmed

Analysis of minK and eNOS genes as candidate loci for predisposition to non-valvular atrial fibrillation.

MINK1 NOS3

2.49e-052174216760206
Pubmed

Mutational spectrum of the APC and MUTYH genes and genotype-phenotype correlations in Brazilian FAP, AFAP, and MAP patients.

APC MUTYH

2.49e-052174223561487
Pubmed

Isolation, characterization, and function of EBAF/LEFTY B: role in infertility.

LEFTY2 LEFTY1

2.49e-052174221401636
Pubmed

Monoacylglycerol acyltransferase-2 inhibits colorectal carcinogenesis in APCmin+/- mice.

MOGAT2 APC

2.49e-052174239055928
Pubmed

Enhancement of the adhesive and spreading potentials of ovarian carcinoma RMG-1 cells due to increased expression of integrin alpha5beta1 with the Lewis Y-structure on transfection of the alpha1,2-fucosyltransferase gene.

ITGA5 FUT2

2.49e-052174220172014
Pubmed

Germline hypermethylation of the APC promoter is not a frequent cause of familial adenomatous polyposis in APC/MUTYH mutation negative families.

APC MUTYH

2.49e-052174218027849
Pubmed

Molecular analysis of the APC and MUTYH genes in Galician and Catalonian FAP families: a different spectrum of mutations?

APC MUTYH

2.49e-052174219531215
Pubmed

Contribution of APC and MUTYH mutations to familial adenomatous polyposis susceptibility in Hungary.

APC MUTYH

2.49e-052174226446593
Pubmed

A reciprocal shift in transient receptor potential channel 1 (TRPC1) and stromal interaction molecule 2 (STIM2) contributes to Ca2+ remodeling and cancer hallmarks in colorectal carcinoma cells.

STIM2 TRPC1

2.49e-052174225143380
Pubmed

LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway.

LEFTY2 LEFTY1

2.49e-052174232745796
Pubmed

Germline mutations in APC and MUTYH are responsible for the majority of families with attenuated familial adenomatous polyposis.

APC MUTYH

2.49e-052174217489848
Pubmed

Characterizing germline APC and MUTYH variants in Ashkenazi Jews compared to other individuals.

APC MUTYH

2.49e-052174232743790
Pubmed

Clinical and genetic characterization of classical forms of familial adenomatous polyposis: a Spanish population study.

APC MUTYH

2.49e-052174220924072
Pubmed

Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status.

APC LYST

2.49e-05217429041176
Pubmed

Lefty1 and lefty2 control the balance between self-renewal and pluripotent differentiation of mouse embryonic stem cells.

LEFTY2 LEFTY1

2.49e-052174224147624
Pubmed

Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer metastasis.

STIM2 NFATC2

2.49e-052174231464639
Pubmed

Prevalence and phenotypes of APC and MUTYH mutations in patients with multiple colorectal adenomas.

APC MUTYH

2.49e-052174222851115
Pubmed

Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk.

APC MUTYH

2.49e-052174218612690
Pubmed

Giant cadherins Fat and Dachsous self-bend to organize properly spaced intercellular junctions.

FAT4 DCHS1

2.49e-052174225355906
Pubmed

Fibronectin assembly during early embryo development: A versatile communication system between cells and tissues.

FN1 ITGA5

2.49e-052174226845241
Pubmed

Placental DNA methylation at term reflects maternal serum levels of INHA and FN1, but not PAPPA, early in pregnancy.

FN1 INHA

2.49e-052174226654447
Pubmed

Lefty antagonises TGF-beta1 induced epithelial-mesenchymal transition in tubular epithelial cells.

LEFTY2 LEFTY1

2.49e-052174220171171
Pubmed

Stra3/lefty, a retinoic acid-inducible novel member of the transforming growth factor-beta superfamily.

LEFTY2 LEFTY1

2.49e-05217429496783
InteractionNUP210P1 interactions

IFT140 FAT4 VPS13C FAT3 CELSR1 DCHS1

1.35e-06421706int:NUP210P1
InteractionZBBX interactions

FAT4 POLE FAT3 CELSR1 SORL1

5.73e-06311705int:ZBBX
InteractionFAHD1 interactions

INHA FPGS CYP24A1 ACAD10 PIR MRPL35 GDA MRPL24 QRSL1

1.51e-051711709int:FAHD1
InteractionDCANP1 interactions

FAT4 FAT3 CELSR1 DCHS1

1.72e-05191704int:DCANP1
InteractionCALM1 interactions

AMFR GAPVD1 STIM2 VPS13C IQSEC2 TOM1 CUL7 LYST ESCO1 MYLK2 DMXL1 VPS13D SVIL PAN2 HERC2 NOS3 PCNT

2.32e-0562617017int:CALM1
InteractionC2CD4B interactions

FAT4 FAT3 APC CELSR1 SVIL

3.35e-05441705int:C2CD4B
InteractionCARD16 interactions

FAT4 FAT3 CARD8

4.77e-0591703int:CARD16
CytobandEnsembl 112 genes in cytogenetic band chr2q35

FN1 INHA SLC4A3 PTPRN NHEJ1 MARCHF4 SLC23A3

6.74e-071291747chr2q35
GeneFamilyCadherin related

FAT4 FAT3 DCHS1

1.44e-0417111324
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

SIGLEC12 DSCAML1 HMCN2 PTPRF SIGLEC6 SIGLEC1

4.76e-041611116593
GeneFamilyCD molecules|C2-set domain containing|Sialic acid binding Ig like lectins

SIGLEC12 SIGLEC6 SIGLEC1

6.60e-04281113745
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PREX2 AKAP13 ARHGEF2 SOS2

7.24e-04661114722
GeneFamilyCullins

CUL9 CUL7

1.02e-03811121032
GeneFamilyC2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors

SIGLEC12 NECTIN4 SIGLEC1

1.89e-03401113592
GeneFamilyFibronectin type III domain containing

FN1 DSCAML1 PTPRF ASTN1 SORL1

3.08e-031601115555
GeneFamilyAdenosine receptors|V-set domain containing

SIGLEC12 SIGLEC6 VCAN NECTIN4 SIGLEC1

3.33e-031631115590
GeneFamilyExonucleases

ISG20 PAN2

4.24e-03161112544
GeneFamilyDyneins, axonemal

DNAH14 DNAH11

4.78e-03171112536
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FN1 ITGA5 PIR F5 PREX2 ARAP3 FAM181B CDH5 NOS3

6.05e-081891749c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

STRBP VPS13C ARHGAP17 LYST DMXL1 PIKFYVE EIF2AK3 BANK1 NOTCH2

7.57e-081941749ff661419b697aef51a53fdeac8d37d870d65f491
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 HID1 ITGA5 PREX2 BMPR2 ARAP3 DCHS1 CDH5 NOS3

9.01e-081981749259fbcc0f2ac281a3e4d693de45b986fe5e24841
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 FN1 HIPK4 PIR DCHS1 FAM181B CDH5 NOS3

6.95e-071851748f98af3146ec2f44c30d31a662fb9c4fa3ca4f706
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APC HID1 LYST ESCO1 PREX2 BMPR2 CDH5 NOS3

7.24e-0718617480ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCellControl-Endothelial_cells-Arterial_endothelial_cells|Control / group, cell type (main and fine annotations)

ITGA5 PIR PREX2 BMPR2 ARAP3 PLCXD3 CDH5 NOS3

7.54e-07187174881affaab3fe3e1daea45ada6445e906ddd33950e
ToppCellControl-Endothelial_cells|Control / group, cell type (main and fine annotations)

STARD13 ITGA5 PREX2 BMPR2 ARAP3 PLCXD3 CX3CL1 CDH5

7.85e-0718817483953b08abfea93468fc8d177bdb16ca7c6ffa1ab
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FN1 ITGA5 F5 PREX2 ARAP3 FAM181B CDH5 NOS3

8.17e-071891748b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

STARD13 IFT140 PREX2 BMPR2 ARAP3 PLCXD3 CX3CL1 CDH5

8.17e-071891748b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCellLPS-IL1RA-Endothelial-Endothelial-Artery|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FN1 ITGA5 PIR F5 PREX2 ARAP3 FAM181B NOS3

8.50e-071901748aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FN1 SLC24A3 PREX2 PGR MOXD1 PIEZO2 GYG1 ASTN1

8.84e-071911748fa380a8752de158974b2ae5e741573439719cc0d
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAT4 FN1 PIR F5 PREX2 ARAP3 FAM181B NOS3

8.84e-0719117484b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCell5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ITGA5 LYST PREX2 BMPR2 DCHS1 PLCXD3 CDH5 NOS3

9.56e-071931748c0973a2c97deb7176c2f617c8760a55f7edc9839
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 ITGA5 PREX2 BMPR2 HMCN2 C3orf80 CDH5 NOS3

9.56e-071931748cc355b2ed6510619cad969ae074126d7c8db784d
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FN1 SLC24A3 PREX2 PGR MOXD1 PIEZO2 GYG1 VCAN

9.94e-071941748a3e5a15cf6c1361207f661ee15eb634f77daf1cb
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ARMC7 FAT3 MUC16 HID1 CUL7 NOP14 CLNK SLC4A11

1.16e-061981748dd0465b45b02cb8edf0914d19afb52fcaaeb012c
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 ITGA5 PREX2 BMPR2 ARAP3 DCHS1 CDH5 NOS3

1.20e-0619917488b62d43af8b2ebb4c1b2d068d50beaf35728dbe7
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 ITGA5 PREX2 BMPR2 ARAP3 DCHS1 CDH5 NOS3

1.20e-061991748da5a88749d859d535daa030d0974485906cc0ba7
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 ITGA5 PREX2 BMPR2 ARAP3 DCHS1 CDH5 NOS3

1.25e-062001748b1be27d134a8633e3e7862c6a0d7be2001d387f0
ToppCellLPS_IL1RA-Endothelial-Endothelial-Artery|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FAT4 FN1 PIR F5 PREX2 ARAP3 CDH5 NOS3

1.25e-062001748ac9ead34afa14067171833f5c277eaf06db7b02e
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 ITGA5 PREX2 BMPR2 ARAP3 DCHS1 CDH5 NOS3

1.25e-062001748dba96cda5f3b780a3d4171b61bc8aaddc1f5d466
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 ITGA5 PREX2 BMPR2 ARAP3 DCHS1 CDH5 NOS3

1.25e-0620017482e47888e041ec3d265425d1df97b6665c6da889c
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 ITGA5 PREX2 BMPR2 ARAP3 DCHS1 CDH5 NOS3

1.25e-06200174850fa0f8a3e490d5941b34e66a10158eba6c909d4
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 ITGA5 PREX2 BMPR2 ARAP3 DCHS1 CDH5 NOS3

1.25e-0620017487a69ad5b6c84f1aebacea5cacb9bc5c63dfd1dac
ToppCellPND07-28-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D|PND07-28-samps / Age Group, Lineage, Cell class and subclass

INHA BMPR2 ARAP3 ASTN1 FUT2 CDH5 NOS3

1.34e-061401747b9aeb7dda7f377b580dd8a44912f300721437387
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

STARD13 NEU4 CYP24A1 ITGA5 OLR1 PREX2 SIGLEC1

2.75e-061561747e0aef6104be16b12304b8e30358f444c1660e92f
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

STARD13 NEU4 CYP24A1 ITGA5 OLR1 PREX2 SIGLEC1

2.75e-0615617475b2781d38a83b4b0f8a53cf321ce5db3a07d0818
ToppCellfacs-Aorta-Heart-3m-Endothelial-endocardial_endothelial_cells|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP24A1 HID1 ITGA5 CELSR1 MAPK15 C3orf80 NOS3

4.31e-061671747a4a795751644b22af616335379e64ae95175180c
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IFT140 STIM2 DONSON CUL7 ZNF691 PAN2 NOS3

5.24e-0617217478a6a2b4c6654bc976e60a02d0e7303a9071ed55f
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCNB2 F5 PTPRN C3orf80 PLCXD3 FAM181B MARCHF4

6.09e-0617617472e1003dc373b14d27f0464d980453fdcfc1005f0
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAT4 FN1 ITGA5 PREX2 ARAP3 CDH5 NOS3

6.56e-0617817475f779a66aa42d1d8e8af17b4a08d5dcc733efd4c
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HID1 KCNB2 MLXIPL PTPRN PLCXD3 FAM181B MARCHF4

6.80e-061791747ec7c38464863ac3744a8d4880f49421914892339
ToppCellControl-Endothelial_cells-Capillary_endothelial_cells|Control / group, cell type (main and fine annotations)

STARD13 IFT140 ITGA5 ARAP3 PLCXD3 CX3CL1 CDH5

7.06e-061801747b043f9ffb9a4cd427a15bebb86a711c7b08866e8
ToppCell5'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FAT4 FN1 SGCA SLC24A3 SHISAL1 VCAN SVIL

7.86e-061831747af8d86f15a549064530d94bd47081daf59d58ecd
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-2|TCGA-Kidney / Sample_Type by Project: Shred V9

FN1 SGCA ITGA5 PREX2 DCHS1 C3orf80 RASD2

8.74e-0618617471e6526fc9e9381b7ace864588cc7bd80194338d6
ToppCelldroplet-Heart-nan-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SUPT20H FN1 HID1 PIR LYST BMPR2 NOS3

9.70e-0618917478e583ec4df0f5b79ce5211cc99ecd8616d180bde
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 ITGA5 OVCH1 PREX2 ARAP3 CDH5 NOS3

9.70e-06189174712b6f1c3bf526b90e112374bf937701f645c5780
ToppCelldroplet-Heart-nan-3m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SUPT20H FN1 HID1 PIR LYST BMPR2 NOS3

9.70e-061891747fb2253b8463d08b3d28e952a31a23dea2c2d986b
ToppCellCOVID_vent-Lymphocytic-B_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

STRBP ARHGAP17 PIKFYVE CELSR1 SIGLEC6 QRSL1 BANK1

1.00e-05190174740b5e9e8f8fd8d84cb5b43e67b49267082348e9f
ToppCellCOVID_vent-Lymphocytic-B_cell-|COVID_vent / Disease condition, Lineage, Cell class and subclass

STRBP ARHGAP17 PIKFYVE CELSR1 SIGLEC6 QRSL1 BANK1

1.00e-051901747a37a32dc1b931562a6660074e19d5598efc65284
ToppCellP07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

HID1 ITGA5 PIR MOXD1 FAM181B NOS3 RASD2

1.00e-051901747e1b721bb74561fe51c53328a0394c9954e489049
ToppCell(5)_Fibroblasts-(5)_Fibroblast-C_(Myofibroblast)|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

FN1 SGCA FAT3 LEFTY2 MOXD1 PIEZO2 SORL1

1.00e-05190174771e112dfb8c3190fe0286b45a046ea789eb6a8db
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSSC4 MLXIPL PTPRF PTPRN RASD1 ASTN1 AKAP13

1.04e-0519117473387b95a3f2445c672d407922fdce3a91eabaef8
ToppCell343B-Endothelial_cells-Endothelial-B_(Artery)|343B / Donor, Lineage, Cell class and subclass (all cells)

FN1 PREX2 BMPR2 PNPLA1 DCHS1 PLCXD3 CDH5

1.04e-05191174727a532a35d9e8822014f581fd56c4ca62e39f8fe
ToppCell343B-Endothelial_cells-Endothelial-B_(Artery)-|343B / Donor, Lineage, Cell class and subclass (all cells)

FN1 PREX2 BMPR2 PNPLA1 DCHS1 PLCXD3 CDH5

1.04e-0519117471dfcff08e01e6a695953334342bcfde04ba005ad
ToppCellEndothelial-A-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

FAT4 ITGA5 PREX2 BMPR2 DCHS1 PLCXD3 CDH5

1.04e-051911747f702dfe88a9b04091dae87df61b2b4f43525f86a
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 FN1 ITGA5 PREX2 RASD1 CDH5 NOS3

1.04e-051911747b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HID1 KCNB2 MLXIPL PTPRN RASD1 FAM181B MARCHF4

1.07e-0519217478df4cfe1461819756138ff1180896238dca2787e
ToppCellfacs-MAT-Fat-24m-Endothelial-endothelial_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARAP3 RASD1 FUT2 FAM181B CX3CL1 CDH5 NOS3

1.11e-051931747724bb613fa434add5b1c5586b629328f819fbdfe
ToppCellfacs-MAT-Fat-24m-Endothelial|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARAP3 RASD1 FUT2 FAM181B CX3CL1 CDH5 NOS3

1.11e-051931747737e540c72a3cfe8dbd4c0f139f7d729a166793a
ToppCellfacs-MAT-Fat-24m-Endothelial-nan|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARAP3 RASD1 FUT2 FAM181B CX3CL1 CDH5 NOS3

1.11e-051931747ba9a47e2dc01efa6d2a99b1631d4951fac2648d4
ToppCellClub_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

MUC16 DDX11 PTPRF NECTIN4 FUT2 CX3CL1 SLC4A11

1.11e-0519317476582c0367052b9d10fb629c383ee0c55872afd2d
ToppCellClub_cells|World / lung cells shred on cell class, cell subclass, sample id

MUC16 DDX11 PTPRF NECTIN4 FUT2 CX3CL1 SLC4A11

1.11e-0519317479d3165dc5763a07a7d873f497624d9d6528fa2db
ToppCellCOVID-19-Heart-Fib_2|Heart / Disease (COVID-19 only), tissue and cell type

FN1 TBX18 MOXD1 HMCN2 VCAN PCSK6 NOTCH2

1.15e-051941747d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FAT4 FN1 FAT3 MOXD1 PIEZO2 GYG1 VCAN

1.15e-051941747011e14d9ed1393275f892060e7708ffadcd0767f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAT4 FN1 ITGA5 PREX2 ARAP3 CDH5 NOS3

1.15e-051941747b0c15e7e4bcf30856fb628dedd7ba82df33489f5
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 ITGA5 PREX2 BMPR2 ARAP3 CDH5 NOS3

1.23e-0519617478ad8efb631164b46f0c082572270188e5ead20bf
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 ITGA5 PREX2 BMPR2 PIEZO2 ARAP3 CDH5

1.23e-051961747023312af38f816a44b407e0daa32590d953caf99
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

OVCH1 PREX2 ARAP3 DCHS1 C3orf80 CDH5 NOS3

1.23e-051961747915e4a7422058be246b54760df31e8a607310625
ToppCellnucseq-Endothelial-Endothelial_Vascular|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

STARD13 PREX2 BMPR2 ARAP3 PLCXD3 CX3CL1 CDH5

1.23e-051961747686533fd3fba8e4df96b9dd1307e870e89db4332
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FAT4 FN1 FAT3 MOXD1 PIEZO2 GYG1 VCAN

1.23e-0519617471450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAT4 SLC24A3 PGR MOXD1 PIEZO2 VCAN PLCXD3

1.23e-051961747a12dd986df65c36f248cf10815c3b8b6238613b0
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAT4 SLC24A3 PGR MOXD1 PIEZO2 VCAN PLCXD3

1.23e-0519617473e6803587d8566fd08cb8b290be3b6461743d79c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 ITGA5 PREX2 BMPR2 ARAP3 CDH5 NOS3

1.23e-0519617479606ea7e42f707e69ea891b3521037613b9675f5
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FAT4 ITGA5 OVCH1 PREX2 ARAP3 CDH5 NOS3

1.23e-051961747e224338490691d92c1f70b57112fabdcc92b06a9
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FN1 SGCA FAT3 LEFTY2 LEFTY1 MOXD1 PIEZO2

1.27e-05197174713896ec65ccda0b928c91d41112dc01b480036b7
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FAT4 FN1 SGCA BBS1 BTBD9 PGR RASD2

1.27e-0519717472872a78b1be61aa1d50bc9a49294a21e922dc033
ToppCell5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ITGA5 PIR PREX2 BMPR2 PLCXD3 CDH5 NOS3

1.27e-05197174787eda06344498dc66cac292cf89746dc90b5cf67
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA5 PREX2 BMPR2 PIEZO2 ARAP3 CDH5 NOS3

1.27e-051971747cd509e49bbdbf991cc5913960ff3ef275ad40628
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ITGA5 LYST PREX2 ARAP3 PLCXD3 CDH5 NOS3

1.27e-051971747b0036cf3f7e6edf8e43f16cd2f0f0e80471d2576
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA5 PREX2 BMPR2 PIEZO2 ARAP3 CDH5 NOS3

1.27e-051971747412cb5f37df57121ddd1492021445479c7cbccbf
ToppCellBronchus_Control_(B.)|World / Sample group, Lineage and Cell type

STIM2 CYP24A1 MUC16 GDA SIPA1L1 FUT2 BANK1

1.27e-051971747b6dff2ee108813e18657e2d8cf850e2423f8c8e9
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FAT4 FN1 FAT3 SLC24A3 PIEZO2 GYG1 VCAN

1.27e-05197174711a4c417f035e554431a8f03be13b5eefa3530c0
ToppCellIPF-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

FAT4 FN1 SLC24A3 DNAH14 MOXD1 PIEZO2 VCAN

1.27e-051971747f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA5 PREX2 BMPR2 PIEZO2 ARAP3 CDH5 NOS3

1.31e-05198174731ba87552be97c9b78c9e82f98e96699ccb19824
ToppCell5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FN1 ITGA5 PREX2 BMPR2 ARAP3 CX3CL1 CDH5

1.31e-05198174758508a8df2714d769f137794c29441a7bd38b350
ToppCellproximal-Endothelial-Artery-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PIR BMPR2 ARAP3 PNPLA1 PLCXD3 CDH5 NOS3

1.31e-051981747a56b80bdc824e4cc60366f273fb616cd0efec456
ToppCellproximal-3-Endothelial-Artery|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PIR BMPR2 ARAP3 PNPLA1 PLCXD3 CDH5 NOS3

1.31e-051981747946f72b594d22ae7b8e4c22483814c284cb43eea
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FAT4 FN1 FAT3 MOXD1 PIEZO2 GYG1 VCAN

1.31e-05198174717dc055e2a289496d9c5cdbf3297bdf906dc6d22
ToppCellCOVID-19-lung-Capillary_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC26A3 ITGA5 PREX2 BMPR2 ARAP3 CX3CL1 CDH5

1.31e-05198174745419f2804b4be79bae6632e71c54e1af482d115
ToppCellproximal-Endothelial-Artery|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PIR BMPR2 ARAP3 PNPLA1 PLCXD3 CDH5 NOS3

1.31e-0519817470e5572298676b6c2a2b1a77967574020b664aebd
ToppCellproximal-mesenchymal-Alveolar_Fibroblast|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FN1 SGCA FAT3 LEFTY2 LEFTY1 MOXD1 PIEZO2

1.35e-0519917477f4840ae6a888380feca722543e5e52783f3e35d
ToppCellproximal-3-mesenchymal-Alveolar_Fibroblast|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FN1 SGCA FAT3 LEFTY2 LEFTY1 MOXD1 PIEZO2

1.35e-051991747301d02bbb37e6f1d24b6e865bc3fe3e91260eb30
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 ITGA5 BMPR2 ARAP3 DCHS1 CDH5 NOS3

1.35e-051991747f35e9c05d0a0339ff691b38564da7aad8e9218aa
ToppCell18-Distal-Mesenchymal-Mesenchyme_RSPO2+|Distal / Age, Tissue, Lineage and Cell class

FN1 FAT3 LEFTY1 MOXD1 PIEZO2 GYG1 VCAN

1.35e-05199174795403988caef322314f4ed15415ad1a9a987adc1
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 ITGA5 PREX2 BMPR2 ARAP3 CDH5 NOS3

1.35e-05199174733f1669eeb701986b4dec409efdb6c06c3c41c2b
ToppCellSepsis-Bac-SEP-Lymphocyte-T/NK-Treg|Bac-SEP / Disease, condition lineage and cell class

BBS1 ISG20 ACY1 OSBPL2 NOS3 ZNF345 SENP5

1.35e-051991747e0b6136e28b813299b7ffbe37f1cf830e60cd7d8
ToppCellTracheal-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Duct|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

GPR12 MOGAT2 MUC16 HID1 FUT2 CX3CL1 SLC4A11

1.35e-051991747ef1a0c278c23614fd6a3218a9733abe6ecd6f686
ToppCell18-Airway-Mesenchymal-Mesenchyme_RSPO2+|Airway / Age, Tissue, Lineage and Cell class

FN1 NUF2 LEFTY1 MOXD1 PIEZO2 GYG1 VCAN

1.35e-0519917477ac35e8f45dcdc702422dabd8f3e4d03e2bf61af
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_vascular|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ITGA5 PREX2 ARAP3 PLCXD3 CX3CL1 CDH5 NOS3

1.35e-051991747d58edc5f74970bb26d844746184e4bae7c494d6b
ToppCellproximal-mesenchymal-Alveolar_Fibroblast-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FN1 SGCA FAT3 LEFTY2 LEFTY1 MOXD1 PIEZO2

1.35e-0519917479a16e519fb0651a7c4d8e05b931df4fb3b0eb3d1
ToppCellTracheal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

STARD13 ITGA5 PREX2 ARAP3 PNPLA1 CDH5 NOS3

1.35e-0519917479735a1dc10910f02f1106b20ae5ab4c09c21305e
ToppCellASK452-Endothelial|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

STARD13 ITGA5 PREX2 BMPR2 CX3CL1 CDH5 NOS3

1.35e-0519917470bc97a9a78aaafd1554ae6a61356ed9ea4983fa5
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Vein|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

STIM2 F5 PREX2 BMPR2 ARAP3 CDH5 NOS3

1.35e-051991747cfb624c7728046fc7f3ef071f57e4d7b013f3fef
ToppCellwk_15-18-Mesenchymal-Fibroblast-Alveolar_fibro|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FN1 FAT3 LEFTY1 MOXD1 PIEZO2 GYG1 VCAN

1.35e-0519917476bce8e65859a35cfea1c210f9c9765952d492ed2
ToppCell10x5'v1-week_14-16-Endothelial-stroma-tip_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FN1 HID1 PIEZO2 OIT3 DCHS1 CDH5 NOS3

1.40e-05200174777ac1aa73c16a4f595ff01c6b4e171e0b8fed1e6
ToppCellTracheal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FAT4 FN1 ITGA5 PREX2 ARAP3 CDH5 NOS3

1.40e-0520017475ec31c1be6bcc4124e1489d136570f3de33cc2e9
ToppCellControl_saline-Endothelial-Endothelial-Artery|Control_saline / Treatment groups by lineage, cell group, cell type

FN1 STRBP PIR F5 PREX2 CDH5 NOS3

1.40e-05200174765b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FAT4 STIM2 PREX2 BMPR2 ARAP3 CDH5 NOS3

1.40e-052001747b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 ITGA5 PREX2 BMPR2 ARAP3 DCHS1 CDH5

1.40e-052001747ced14d83222dbebca85c40540e76824e683354f3
DrugY-27632

STARD13 FN1 APC OLR1 MYLK2 PIKFYVE LEFTY2 LEFTY1 MOXD1 MAPK15 RASD1 CDH5 EIF2AK3 NOS3

6.59e-0644417014CID000005711
DrugForskolin, from Coleus forskohlii; Up 200; 0.5uM; MCF7; HT_HG-U133A

ZNF573 FN1 INHA CYP24A1 ISG20 CUL7 CARD8 SVIL ARHGEF2

1.09e-0518517097055_UP
DrugBeta-Escin [11072-93-8]; Down 200; 3.2uM; PC3; HT_HG-U133A

FAT4 ZNF573 FN1 TRPC1 MINK1 APC SHISAL1 SIGLEC6 ZC3H7B

1.59e-0519417093807_DN
DrugTrimipramine maleate salt [521-78-8]; Down 200; 9.8uM; MCF7; HT_HG-U133A

IFT140 TRPC1 ITGA5 LYST VPS13D SIPA1L1 NOTCH2 SMG6 SOS2

1.73e-0519617093342_DN
DrugTremorine dihydrochloride [300-68-5]; Up 200; 15uM; MCF7; HT_HG-U133A

MINK1 F5 SLC4A3 EPS15L1 SIGLEC6 VCAN PCSK6 ASTN1 FUT2

1.80e-0519717093196_UP
DrugNitrarine dihydrochloride [20069-05-0]; Down 200; 10.6uM; MCF7; HT_HG-U133A

ZNF573 SUPT20H SLC24A3 ACAD10 VPS13D OSBPL2 AKAP13 ARHGEF2 ZC3H7B

1.87e-0519817096043_DN
DrugHarmane hydrochloride [21655-84-5]; Up 200; 18.2uM; PC3; HT_HG-U133A

FN1 APC F5 SIGLEC6 VCAN ARHGEF2 CDH5 SMG6 SOS2

1.87e-0519817094584_UP
DrugFlecainide acetate [54143-56-5]; Down 200; 8.4uM; MCF7; HT_HG-U133A

AMFR IQSEC2 MINK1 CUL9 SIGLEC6 SIPA1L1 ZC3H7B SOS2 SENP5

1.87e-0519817093843_DN
DrugNafcillin sodium salt monohydrate [7177-50-6]; Up 200; 8.8uM; MCF7; HT_HG-U133A

CYP2B6 TRPC1 APC PGR VPS13D VCAN PCSK6 ARHGEF2 SOS2

1.87e-0519817094103_UP
DrugFluorometholone [426-13-1]; Down 200; 10.6uM; MCF7; HT_HG-U133A

ACAD10 PREX2 SIGLEC6 SIPA1L1 PCSK6 ARHGEF2 ZC3H7B SORL1 SOS2

2.03e-0520017096071_DN
DiseaseBenign neoplasm of stomach

POLE APC AXIN2 MUTYH

2.22e-06171674C0153943
DiseaseNeoplasm of uncertain or unknown behavior of stomach

POLE APC AXIN2 MUTYH

2.22e-06171674C0496905
DiseaseCarcinoma in situ of stomach

POLE APC AXIN2 MUTYH

2.22e-06171674C0154060
DiseaseColorectal Carcinoma

DONSON FN1 POLE FPGS APC KCNB2 F5 DSCAML1 PREX2 AXIN2 ARAP3 DCHS1 PAN2 CDH5 MUTYH SORL1

2.66e-0670216716C0009402
DiseaseStomach Carcinoma

POLE APC AXIN2 MUTYH

5.49e-06211674C0699791
DiseaseStomach Neoplasms

FAT4 POLE APC ITGA5 AXIN2 PTPRF BOP1 NOS3 MUTYH NOTCH2

8.07e-0629716710C0038356
DiseaseMalignant neoplasm of stomach

FAT4 POLE APC ITGA5 AXIN2 PTPRF BOP1 NOS3 MUTYH NOTCH2

8.81e-0630016710C0024623
DiseaseVan Maldergem Wetzburger Verloes syndrome

FAT4 DCHS1

3.18e-0521672C1832390
DiseaseVan Maldergem syndrome

FAT4 DCHS1

3.18e-0521672cv:C1832390
DiseasePeriventricular gray matter heterotopia

FAT4 DCHS1

3.18e-0521672C1849173
Diseaselow density lipoprotein cholesterol measurement, physical activity

CYP7A1 OGDH DDX18 FUT2 DNAH11

3.70e-05661675EFO_0003940, EFO_0004611
DiseaseMalignant neoplasm of breast

AMFR FN1 STRBP CYP24A1 ACY1 PGR DAP3 BMPR2 ARAP3 RPRD1A SIPA1L1 DDX18 HERC2 ZNF281 CDH5 NOS3 NOTCH2 SORL1

4.08e-05107416718C0006142
Diseaseuric acid measurement

FAT4 FAT3 CYP24A1 SLC22A11 ARHGAP17 ACAD10 F5 MLXIPL BMPR2 NFATC2 AKAP13 WDR72 SOS2

4.76e-0561016713EFO_0004761
Diseaseanemia (implicated_via_orthology)

APC SLC4A3 SLC4A11

7.71e-05151673DOID:2355 (implicated_via_orthology)
DiseasePolyposis, Adenomatous Intestinal

APC F5 MUTYH

9.45e-05161673C2713442
DiseaseFamilial Intestinal Polyposis

APC F5 MUTYH

9.45e-05161673C2713443
Diseaseautosomal recessive spinocerebellar ataxia 4 (implicated_via_orthology)

VPS13C VPS13D

9.52e-0531672DOID:0111611 (implicated_via_orthology)
DiseaseAbruptio Placentae

MTHFD1 NOS3

9.52e-0531672C0000832
DiseaseHeterotopia, Periventricular, Autosomal Recessive

FAT4 DCHS1

9.52e-0531672C1842563
DiseaseHMG CoA reductase inhibitor use measurement

CYP7A1 MLXIPL BMPR2 OIT3 FUT2 NOS3 DNAH11

1.06e-041891677EFO_0009932
DiseaseAdenomatous Polyposis Coli

APC F5 MUTYH

1.14e-04171673C0032580
Diseaseobesity (implicated_via_orthology)

FAT4 GPR12 STIM2 BBS1 PNPLA1 DCHS1 NOTCH2

2.34e-042151677DOID:9970 (implicated_via_orthology)
Diseaseportal hypertension (biomarker_via_orthology)

F5 CX3CL1 NOS3

2.53e-04221673DOID:10762 (biomarker_via_orthology)
DiseaseHereditary Diffuse Gastric Cancer

FAT4 APC ITGA5 PTPRF BOP1 NOS3 MUTYH NOTCH2

2.79e-042931678C1708349
DiseaseSTROKE, ISCHEMIC

F5 NOS3

3.15e-0451672601367
DiseaseIschemic stroke

F5 NOS3

3.15e-0451672cv:C0948008
Diseaseirritable bowel syndrome (implicated_via_orthology)

MLXIPL NOS3

3.15e-0451672DOID:9778 (implicated_via_orthology)
Diseasefibroblast growth factor 19 measurement

CYP7A1 FUT2

3.15e-0451672EFO_0010782
Diseaseinflammatory biomarker measurement

F5 PIEZO2 PCSK6

4.21e-04261673EFO_0004872
Diseasehepatopulmonary syndrome (biomarker_via_orthology)

CX3CL1 NOS3

4.71e-0461672DOID:900 (biomarker_via_orthology)
Diseasecolorectal cancer (is_implicated_in)

POLE CYP24A1 APC CHD4 AXIN2

6.41e-041211675DOID:9256 (is_implicated_in)
Diseasecolorectal cancer (implicated_via_orthology)

POLE APC NOTCH2

6.46e-04301673DOID:9256 (implicated_via_orthology)
Diseasepulmonary hypertension (is_implicated_in)

F5 BMPR2 NOS3

6.46e-04301673DOID:6432 (is_implicated_in)
Diseasecalcineurin subunit B type 1 measurement

PCSK6 PLCXD3

6.56e-0471672EFO_0020215
Diseaseautoantibody measurement

STIM2 DCAF5

6.56e-0471672EFO_0004866
Diseaseputamen volume

FAT3 DSCAML1 MYLK2

7.12e-04311673EFO_0006932
Diseaseresponse to aromatase inhibitor

MUC16 SVIL CNOT1

7.83e-04321673GO_0061477
DiseaseVaricose veins

STIM2 EPS15L1 NFATC2 PCSK6 AKAP13 FUT2

8.34e-041931676HP_0002619
Diseaselung cancer (is_implicated_in)

POLE CYP24A1 CHD4 AXIN2

8.37e-04741674DOID:1324 (is_implicated_in)
Diseasesialic acid-binding Ig-like lectin 6 measurement

SIGLEC12 SIGLEC6

8.72e-0481672EFO_0008285
Diseaseovarian cancer (implicated_via_orthology)

POLE APC

8.72e-0481672DOID:2394 (implicated_via_orthology)
Diseasepolyunsaturated fatty acid measurement

MOGAT2 CYP7A1 ISG20 MLXIPL DNAH11

9.17e-041311675EFO_0010733
DiseaseDisproportionate short stature

IFT140 CUL7 EIF2AK3 PCNT

9.71e-04771674C0878659
Diseaserectum cancer (is_implicated_in)

CYP24A1 CHD4

1.12e-0391672DOID:1993 (is_implicated_in)
DiseaseSitus ambiguous

PKD1L1 LEFTY2

1.12e-0391672C1167664
Diseasepulmonary hypertension (biomarker_via_orthology)

BMPR2 CX3CL1 CDH5 NOS3

1.12e-03801674DOID:6432 (biomarker_via_orthology)
Diseaseresponse to hydrochlorothiazide, diastolic blood pressure change measurement

PKD1L1 PLCXD3

1.39e-03101672EFO_0005202, EFO_0006945
Diseasecancer antigen 125 measurement

NEU4 MUC16

1.39e-03101672EFO_0010603
DiseasePulmonary Hypertension

BMPR2 NFATC2 NOS3

1.51e-03401673C0020542
DiseasePosterior Choroidal Artery Infarction

F5 NOS3

1.69e-03111672C0887799
DiseaseGastric cancer

APC MUTYH

1.69e-03111672cv:C0024623
DiseaseCerebral Infarction, Left Hemisphere

F5 NOS3

1.69e-03111672C0751010
DiseaseAnterior Choroidal Artery Infarction

F5 NOS3

1.69e-03111672C0751012
DiseaseCerebral Infarction, Right Hemisphere

F5 NOS3

1.69e-03111672C0751011
DiseaseSubcortical Infarction

F5 NOS3

1.69e-03111672C0751014
DiseasePeptic ulcer and gastro-oesophageal reflux disease (GORD) drug use measurement

KCNB2 DNAH11

1.69e-03111672EFO_0009923
DiseaseNeoplasm of stomach

APC MUTYH

1.69e-03111672cv:C0038356
DiseaseCerebral Infarction

F5 NOS3

1.69e-03111672C0007785
Diseasevascular endothelial growth factor D measurement

PIR PCSK6

1.69e-03111672EFO_0010575
Diseaseendometrial carcinoma, endometriosis

AXIN2 PGR

1.69e-03111672EFO_0001065, EFO_1001512
DiseaseGASTRIC CANCER

APC MUTYH

1.69e-03111672613659
DiseaseSecondary Biliary Cholangitis

MMEL1 CDH5 NOS3

1.74e-03421673C0238065
DiseaseBiliary cirrhosis

MMEL1 CDH5 NOS3

1.74e-03421673C0023892
DiseaseBiliary Cirrhosis, Primary, 1

MMEL1 CDH5 NOS3

1.74e-03421673C4551595
Diseasephospholipids:total lipids ratio, high density lipoprotein cholesterol measurement

MOGAT2 KCNB2 MLXIPL NPHP3 PCSK6 BANK1 DNAH11

1.89e-033071677EFO_0004612, EFO_0020946
DiseaseIGF-1 measurement

IFT140 CYP7A1 VPS13C BTBD9 ACY1 OGDH MLXIPL ASTN1 PLCXD3

1.93e-034881679EFO_0004627
DiseaseParoxysmal atrial fibrillation

SGCA LRRC10 ARMH3 NOS3 SORL1

1.99e-031561675C0235480
Diseasefamilial atrial fibrillation

SGCA LRRC10 ARMH3 NOS3 SORL1

1.99e-031561675C3468561
DiseasePersistent atrial fibrillation

SGCA LRRC10 ARMH3 NOS3 SORL1

1.99e-031561675C2585653
Diseaseendometrial carcinoma (is_implicated_in)

POLE APC

2.02e-03121672DOID:2871 (is_implicated_in)
Diseasepulmonary embolism (biomarker_via_orthology)

CX3CL1 NOS3

2.02e-03121672DOID:9477 (biomarker_via_orthology)
DiseaseAdenocarcinoma of large intestine

POLE APC AXIN2 MUTYH

2.19e-03961674C1319315
DiseaseAtrial Fibrillation

SGCA LRRC10 ARMH3 NOS3 SORL1

2.22e-031601675C0004238
DiseaseT-cell surface glycoprotein CD3 epsilon chain measurement

F5 PIKFYVE

2.38e-03131672EFO_0802114
Diseasegallbladder cancer (is_implicated_in)

APC AXIN2

2.38e-03131672DOID:3121 (is_implicated_in)
DiseasePrimary biliary cirrhosis

MMEL1 CDH5 NOS3

2.40e-03471673C0008312
Diseasetestosterone measurement

STARD13 CYP7A1 CYP24A1 IQSEC2 SLC22A11 SLC24A3 NUF2 KIAA0753 MLXIPL PTPRF MTHFD1 KNDC1 MED23 BANK1 WDR72 SOS2

2.47e-03127516716EFO_0004908
Diseasenon-high density lipoprotein cholesterol measurement

AMBN FN1 CYP7A1 BBS1 MLXIPL BMPR2 OIT3 DDX18 FUT2 DNAH11 WDR72

2.56e-0371316711EFO_0005689
Diseaselung adenocarcinoma (is_implicated_in)

CYP24A1 CHD4 AXIN2

2.71e-03491673DOID:3910 (is_implicated_in)
DiseaseWeight Gain

STIM2 VPS13D SIPA1L1 DNAH11

2.73e-031021674C0043094
Diseasemultiple myeloma, monoclonal gammopathy

TOM1 DNAH11

2.77e-03141672EFO_0000203, EFO_0001378
Diseaseamyotrophic lateral sclerosis, age at onset

PTPRF ARHGEF2

3.19e-03151672EFO_0004847, MONDO_0004976
DiseaseSitus ambiguus

PKD1L1 LEFTY2

3.19e-03151672C0266642
DiseaseMyocardial Ischemia

AXIN2 GYG1 CX3CL1 EIF2AK3 NOS3

3.34e-031761675C0151744
Diseasegallstones

CYP7A1 HID1 MLXIPL FUT2

3.36e-031081674EFO_0004210
Diseasesmoking behavior

GAPVD1 CYP2B6 SLC24A3 PTPRF DDX18 SMG6 SORL1

3.39e-033411677EFO_0004318
DiseaseIGFBP-3 measurement

RASGEF1A MLXIPL MAPK15

3.57e-03541673EFO_0004626
Diseasepulmonary hypertension (implicated_via_orthology)

BMPR2 NFATC2 NOS3

3.57e-03541673DOID:6432 (implicated_via_orthology)
DiseaseCiliopathies

BBS1 LEFTY2 NPHP3 DNAH11

3.59e-031101674C4277690
Diseaseinterferon gamma measurement, platelet-derived growth factor BB measurement, interleukin 4 measurement, interleukin 10 measurement, stromal cell-derived factor 1 alpha measurement, interleukin-6 measurement, interleukin 12 measurement, interleukin 17 measurement, vascular endothelial growth factor measurement, fibroblast growth factor basic measurement, granulocyte colony-stimulating factor measurement

F5 PCSK6

3.63e-03161672EFO_0004750, EFO_0004753, EFO_0004762, EFO_0004810, EFO_0008130, EFO_0008142, EFO_0008165, EFO_0008174, EFO_0008184, EFO_0008264, EFO_0008293
DiseaseC-reactive protein measurement

ARMC7 ZNF573 VPS13C CCDC168 HID1 KCNB2 TRIP12 IL22RA1 MLXIPL BMPR2 PTPRF FUT2 BANK1 DNAH11 WDR72

3.65e-03120616715EFO_0004458
DiseaseBreast Carcinoma

FN1 CYP24A1 PGR DAP3 BMPR2 HERC2 CDH5 NOS3 NOTCH2

3.68e-035381679C0678222
Diseasevery low density lipoprotein cholesterol measurement

CYP7A1 DSCAML1 MLXIPL OIT3 FUT2 DNAH11

3.74e-032601676EFO_0008317
DiseaseLipidemias

APC NOS3

4.10e-03171672C1706412
DiseaseAmelogenesis imperfecta

AMBN WDR72

4.10e-03171672cv:C0002452
DiseaseHyperlipidemia

APC NOS3

4.10e-03171672C0020473
Diseaseantihyperlipidemic drug use measurement

CYP7A1 FUT2 DNAH11 WDR72

4.20e-031151674EFO_0803367
DiseaseCarcinoma, Granular Cell

FAT4 APC PGR NOS3

4.33e-031161674C0205644
DiseaseAdenocarcinoma, Tubular

FAT4 APC PGR NOS3

4.33e-031161674C0205645
DiseaseAdenocarcinoma, Oxyphilic

FAT4 APC PGR NOS3

4.33e-031161674C0205642

Protein segments in the cluster

PeptideGeneStartEntry
FQLERPHFTLPGTMV

BANK1

521

Q8NDB2
FFSGDVMIHPVTNRP

BOP1

226

Q14137
MESSELIPRPGHQFA

C2orf16

116

Q68DN1
LLQHSPSPIGSTRML

SMG6

926

Q86US8
GHEVTLSNLNLSMPP

EPS15L1

86

Q9UBC2
PPENTFLRLTAMATH

EPB42

556

P16452
PVRFLFVMLGPSHTS

SLC4A3

551

P48751
MSHLPAVSPVFFQLP

LINC01590

1

Q5TEZ4
IQRFSDLLPMGVPHI

CYP2B6

356

P20813
TPALRPTTGTVHIMD

ARAP3

186

Q8WWN8
GFPTVSVMLPLHSEQ

VCAN

2481

P13611
VLTPMPAYARHTGQV

EIF2AK3

971

Q9NZJ5
TIFQIARLISHGPMP

AMBN

216

Q9NP70
SPPHSPRDFTRMQDI

ARHGEF2

956

Q92974
HNPSLRAPMFLLIGS

GPR12

71

P47775
IQRHSPLGFARQSPM

FAT4

4651

Q6V0I7
LMTISHPGLDNSRPF

AKAP13

1691

Q12802
PMVGSFTINPRLQRH

DNAH11

2626

Q96DT5
HRQQSVLLVPMDTPG

ACAD10

851

Q6JQN1
RTTPRAHLFTQDPAM

AXIN2

671

Q9Y2T1
LAQSHPEMGLVTTPV

ARMH3

316

Q5T2E6
QAMPHPQLFSGESVV

CELSR1

1686

Q9NYQ6
HFLPVVISDNGMPSR

CDH5

551

P33151
TGMVYQTVLLPHRPS

DMXL1

2261

Q9Y485
PFLRENDLSIMHSPS

ASTN1

46

O14525
ILDTSGNHPFPAMRR

RASD1

76

Q9Y272
GNHPFPAMRRLSILT

RASD1

81

Q9Y272
PQHMVGATPFAVARL

ISG20

61

Q96AZ6
SIVIQGFPHPEMTTS

MUC16

7651

Q8WXI7
TPSHELIQAVGPLRM

NFATC2

116

Q13469
EMQPLAHGASTVLPS

NOTCH2

2206

Q04721
ADIFHVNPVGPLLMT

PAN2

321

Q504Q3
FTVDPTTGHVRLMRP

DCHS1

941

Q96JQ0
RMPAYIATQGPLSHT

PTPRN

776

Q16849
THLLVFGMEQRLPPN

LEFTY1

96

O75610
PGTTEHLRFTRPLTM

KTI12

301

Q96EK9
ISPSAALRHPFVSMQ

HIPK4

336

Q8NE63
HFELPGPRMVVTNLL

LMOD3

376

Q0VAK6
MSSFGPDSLLLPHRV

HERC2

4451

O95714
NPQIFTAHPDTMLGR

KCTD20

131

Q7Z5Y7
MLRGRPLFPGTSTLH

MAPK15

211

Q8TD08
SSIRHVPANVGPLMR

HMCN2

4431

Q8NDA2
IEGSVISSPRPHQRM

IQSEC2

1166

Q5JU85
LPNFGSHVLTPAEME

GAPVD1

871

Q14C86
SSRGPHTFLRMDPQV

PCSK6

121

P29122
PLEIMSRNHGIFPFT

OIT3

376

Q8WWZ8
PHLMEGFLPFSNLVT

NUF2

76

Q9BZD4
PFPHRMVELRTGNVS

MYLK2

266

Q9H1R3
SEHPMSFEGIQLPQV

CUL7

231

Q14999
LREPVIQHGPFVMNT

PIR

246

O00625
IITHFSMQGSPPLFL

MED23

776

Q9ULK4
HSVMFNPVEPRLLAT

DCAF5

191

Q96JK2
SLENIARMTHALFPP

PNPLA1

221

Q8N8W4
GNRLTDFPTVLLHMP

LRRC10

176

Q5BKY1
LSAITTLMHLSPPGR

ARMC7

116

Q9H6L4
TELSEMFPVLPGSHL

POLE

2081

Q07864
MAVQAALLSTHPFVP

FAM181B

1

A6NEQ2
TLRPASPLMHIQGFL

DDX11

556

Q96FC9
VATPGRLLDHMQNTP

DDX18

306

Q9NVP1
RHIIYIDQPTLGMPS

MMEL1

246

Q495T6
HMGIRLSQSPLDPRS

NEU4

391

Q8WWR8
PSFHAIMGPLQALLT

NOP14

706

P78316
SPLMPHLFRVRGAVS

OLR1

221

P78380
VSDHPPEQRGMFTIS

PCNT

161

O95613
PEQRGMFTISDHQPE

PCNT

166

O95613
SEAGLRIMITSHFPP

SLC24A3

326

Q9HC58
PISGSLTPVFHQEMV

NOS3

451

P29474
TGFSSIFPGIRPHLM

MOGAT2

126

Q3SYC2
PGRSPLATTVMDFIH

PGR

291

P06401
MGSRTPESPLHAVQL

ITGA5

1

P08648
MGPEHSSARPERFLQ

OGDH

786

Q02218
PTLMQNPSFHSLIEG

PIKFYVE

881

Q9Y2I7
MFAPRHVNLSSLVPS

HEATR5B

1056

Q9P2D3
SHLSLGEIPAMAQPF

GYG1

301

P46976
ASHLQMKFPTDLPGT

KCNB2

626

Q92953
NTTRIHLLPSMNPDG

CPZ

281

Q66K79
EPVEMLHSGTLVPSR

CYP24A1

491

Q07973
SRHGLIPLVNSMDVP

QRSL1

216

Q9H0R6
HPTLIQSTGPLIDMS

DSCAML1

1706

Q8TD84
MIFEEHGFRRTTPPT

FN1

2141

P02751
RPAFIPAQMHSTLAP

FUT2

91

Q10981
PAQMHSTLAPIFRIT

FUT2

96

Q10981
QEMTTFHPESPRILT

FAT3

4261

Q8TDW7
MEHSLKQFSGPDPLS

BMPR2

686

Q13873
EDRFHGVRLQTSPPM

CARD8

351

Q9Y2G2
HEMRVVSPVFLQLPS

C3orf80

181

F5H4A9
NLHIFVIMSPEGPSF

DNAH14

2136

Q0VDD8
THLLVFGMEQRLPPN

LEFTY2

96

O00292
GTVLHFLVRMPPFTK

LYST

3241

Q99698
HEQRSPPGSSRELVM

MARCHF4

391

Q9P2E8
DQFSLEITGPIMPHS

DONSON

466

Q9NYP3
LPLLSSVQIEGHPMS

IL22RA1

496

Q8N6P7
LPGTMRPLHVRTTSD

INHA

331

P05111
LAPVFQPTSHMRLGL

FPGS

341

Q05932
MPPLAHIFRGTFVHS

GDA

6

Q9Y2T3
FRAQPTLPSAHLLAM

KNDC1

1636

Q76NI1
TLFRHSGIAPRTEPM

CUL9

896

Q8IWT3
FPALVAGLPIHMFRT

CYP7A1

216

P22680
GLLRTSFSPPALEMH

ESCO1

416

Q5FWF5
SFMPHLEIQESLPSR

CCDC168

4721

Q8NDH2
MSNSHPLRPFTAVGE

BTBD9

1

Q96Q07
TFLMEQHEPRTPALA

BBS1

91

Q8NFJ9
PSHPSMALNTRFAEV

CHD4

1811

Q14839
FPTPVRMTADGILHT

SLC22A11

456

Q9NSA0
FPRPATSHSLLGMEV

IFT140

711

Q96RY7
SHPENLLPSIFIMGS

PKD1L1

1746

Q8TDX9
PNLMQTLEGTPVFVH

MTHFD1

621

P11586
FDLSMPHVQDPSLVR

PTPRF

1116

P10586
TPHAIIFLPNTDGME

MINK1

1211

Q8N4C8
HGLPPRFVMQVKTFS

DAP3

81

P51398
RQLLTMVSHGPVAPR

SLC4A11

286

Q8NBS3
LNSMAPHPSRDFVVL

STARD13

1001

Q9Y3M8
LAFEHVMTRGVRPPA

SORL1

1831

Q92673
PGQFETFDLMTLHPI

SOS2

766

Q07890
IHAGLEPLTFTNMFP

SVIL

2106

O95425
LGQMPISPDLSHTTL

F5

1226

P12259
LGQMPISPDLSHTTL

F5

1316

P12259
SPNTLILSHFVGRPM

NPHP3

551

Q7Z494
NSRVSEPHRSIFPEM

ARHGAP17

841

Q68EM7
PIVLLSGSMEPAFHR

SEC11B

36

P0C7V7
EVTRDPSILTIPMHF

PIWIL2

591

Q8TC59
FIGMLPSPNQVEHLS

IQCA1L

236

A6NCM1
FMSPGPLVRVTFHAL

OVCH1

931

Q7RTY7
RVPMDIPVFTGTHAD

HID1

446

Q8IV36
VYLRVASGPMPVHTT

FAM90A26

141

D6RGX4
QFRTTPMDSTGVPHI

PITRM1

91

Q5JRX3
HTSVILNRMAPVLPS

MRPL35

71

Q9NZE8
PSGRLMRQDPVVHLS

SIPA1L1

1256

O43166
VMALTHRPNISIPGT

SIGLEC6

141

O43699
TLRGDAHSPPLMTFQ

SHISAL1

181

Q3SXP7
LLSQSGPVHAPVFTM

STRBP

406

Q96SI9
GHMPRTAETLQQLLP

MUTYH

196

Q9UIF7
ASPSLVSQHLIRPLM

NHEJ1

126

Q9H9Q4
TSRHISVGPFPILSM

SLC26A3

121

P40879
MFVTQFTDRGEHPLP

KIAA0753

316

Q2KHM9
HMEPPLGGLRFFSTQ

TEX45

436

Q8NA69
PATGVPITHQRFDQM

MLXIPL

736

Q9NP71
GTMIPSEAPLLHRQV

MRPL24

106

Q96A35
MLSLIPQPQDHGTSL

SIGLEC12

326

Q96PQ1
GIQKHRTSLPAPMFS

OSBPL2

56

Q9H1P3
PLSTLPMFNVHTGER

SGCA

356

Q16586
LSMPPIINGDHSRIT

FARSB

231

Q9NSD9
PRAIQTPGNSSLMLH

SLC23A3

131

Q6PIS1
PTTPMSSHGRVLSLL

AMFR

176

Q9UKV5
TPSNEHFGIVPLEAM

ALG2

321

Q9H553
GFSPMNRTPVLLHDH

ACY1

361

Q03154
NIMSPGSSLPSLHVR

APC

741

P25054
HTFPEVQRMPSQISL

CLNK

191

Q7Z7G1
ELISTLMPIFLGNHP

CNOT1

501

A5YKK6
APKSQFGRIIHTPFM

TRPC1

371

P48995
ESMHSIPLTNLAIPG

PLCXD3

21

Q63HM9
VGVQFHPEFSSRPMK

CTPS2

521

Q9NRF8
PLPEHRSNTMFISET

SENP5

376

Q96HI0
PTHSAEMSLFLQGPE

ZNF691

6

Q5VV52
MFPVLEPHQVGLIRS

ZNF573

1

Q86YE8
LEGHAMPIRSLTFSP

WDR61

186

Q9GZS3
SSRVFMPPHDLLARV

RASGEF1A

76

Q8N9B8
SLFHTIPPGMPEFQS

MOXD1

346

Q6UVY6
LPDLSRLPNVTGSHM

RPRD1A

286

Q96P16
TTLPRIAVHEPSFMI

STIM2

166

Q9P246
RQMLPPVEGVHLLSS

TBX18

566

O95935
LDMLSPIHTPQRTVF

TOM1

156

O60784
SPGYQSRHILLRPTM

SUPT20H

156

Q8NEM7
IPLFSEPTKTTMQGH

PIEZO2

41

Q9H5I5
GLLPATVQPFHLRGM

TSSC4

71

Q9Y5U2
PPHSITAIMITDDQR

WDR72

16

Q3MJ13
RMSHLPPDFEGRQTV

VPS28

166

Q9UK41
TAFRNHPQLSPMISG

TSPYL4

256

Q9UJ04
VMFNHRLPPVTSFTR

ZNF281

51

Q9Y2X9
ILDTSGNHPFPAMRR

RASD2

71

Q96D21
GNHPFPAMRRLSILT

RASD2

76

Q96D21
VPQDTAPLMFSRRHS

TEX13C

616

A0A0J9YWL9
VVPQGTAPLMFSRRH

TEX13C

676

A0A0J9YWL9
FIPEPQMAIHISSGN

VPS13C

2371

Q709C8
SHGLPPRYIMQATDV

PREX2

1551

Q70Z35
VGSLVSPPISLHIFM

SIGLEC1

311

Q9BZZ2
PSTHQRPPSEMADFL

TBC1D15

266

Q8TC07
HPREEMNVPSLRSGS

nan

351

Q3C1V9
TPEDMPTFSIQHQRI

ZNF345

41

Q14585
FGPLGPRMSQLFHRT

TRIP12

416

Q14669
HATMDPQRLGVLITP

CX3CL1

316

P78423
PRTHGPSTFDLQMKF

ZC3H7B

681

Q9UGR2
IMPGDSFAVPLHLTS

VPS13D

3081

Q5THJ4
SEFHLVPSRSMNGQP

NECTIN4

206

Q96NY8