Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	adenylate cyclase binding	AKAP6 CHRNA7 CHRFAM7A	8.41e-05	16	109	3	GO:0008179
GeneOntologyMolecularFunction	RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	NANOGP8 NANOG	1.76e-04	4	109	2	GO:0001010
GeneOntologyBiologicalProcess	cellular response to corticosterone stimulus	FOXO3 NPAS4	2.72e-05	2	108	2	GO:0071386
GeneOntologyBiologicalProcess	positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure	CHRNA7 CHRFAM7A	2.72e-05	2	108	2	GO:0001988
GeneOntologyCellularComponent	spine apparatus membrane	CHRNA7 CHRFAM7A	7.91e-05	3	108	2	GO:0098897
GeneOntologyCellularComponent	plasma membrane raft	AKAP6 SELPLG CHRNA7 STIM1 CHRFAM7A NOS1	1.16e-04	147	108	6	GO:0044853
GeneOntologyCellularComponent	axolemma	CHRNA7 ROBO1 CHRFAM7A	1.67e-04	21	108	3	GO:0030673
GeneOntologyCellularComponent	meiotic cohesin complex	REC8 RAD21L1	5.46e-04	7	108	2	GO:0030893
GeneOntologyCellularComponent	neuron projection membrane	CHRNA7 ROBO1 USH2A CHRFAM7A	8.65e-04	82	108	4	GO:0032589
GeneOntologyCellularComponent	spine apparatus	CHRNA7 CHRFAM7A	9.30e-04	9	108	2	GO:0097444
GeneOntologyCellularComponent	recycling endosome	ATP13A4 ZFYVE27 RAB11FIP1 DENND2B CLCN4 DENND6B	1.04e-03	222	108	6	GO:0055037
GeneOntologyCellularComponent	sarcoplasmic reticulum	AKAP6 CMYA5 STIM1 NOS1	1.13e-03	88	108	4	GO:0016529
GeneOntologyCellularComponent	cohesin complex	REC8 RAD21L1	1.41e-03	11	108	2	GO:0008278
GeneOntologyCellularComponent	NSL complex	KANSL1L PHF20	1.41e-03	11	108	2	GO:0044545
MousePheno	airway basal cell hyperplasia	CHRNA7 CHRFAM7A	3.92e-05	2	88	2	MP:0011115
MousePheno	abnormal airway basal cell differentiation	CHRNA7 CHRFAM7A	3.92e-05	2	88	2	MP:0011114
MousePheno	abnormal airway basal cell morphology	CHRNA7 CHRFAM7A	3.92e-05	2	88	2	MP:0011113
MousePheno	abnormal synaptonemal complex	REC8 RAD21L1 TET1 HSF1	6.61e-05	35	88	4	MP:0009452
Domain	Rad21/Rec8_C_eu	REC8 RAD21L1	9.54e-05	3	106	2	IPR006909
Domain	Rad21_Rec8_N	REC8 RAD21L1	9.54e-05	3	106	2	IPR006910
Domain	Rad21_Rec8_N	REC8 RAD21L1	9.54e-05	3	106	2	PF04825
Domain	Rad21_Rec8	REC8 RAD21L1	9.54e-05	3	106	2	PF04824
Domain	Rad21/Rec8_C	REC8 RAD21L1	9.54e-05	3	106	2	IPR023093
Domain	-	REC8 RAD21L1	9.54e-05	3	106	2	1.10.10.580
Domain	LamGL	PAPPA2 USH2A	1.90e-04	4	106	2	SM00560
Domain	LamG-like	PAPPA2 USH2A	1.90e-04	4	106	2	IPR006558
Domain	LNS2	PITPNM1 LPIN2	4.72e-04	6	106	2	IPR013209
Domain	LNS2	PITPNM1 LPIN2	4.72e-04	6	106	2	SM00775
Domain	OSR1_C	STK39 OXSR1	4.72e-04	6	106	2	PF12202
Domain	LNS2	PITPNM1 LPIN2	4.72e-04	6	106	2	PF08235
Domain	Kinase_OSR1/WNK_CCT	STK39 OXSR1	4.72e-04	6	106	2	IPR024678
Domain	LNS2/PITP	PITPNM1 LPIN2	4.72e-04	6	106	2	IPR031315
Domain	-	ATP13A4 PITPNM1 ATP8A1 LPIN2	4.79e-04	64	106	4	3.40.50.1000
Domain	FN3	PAPPA2 FNDC3A CMYA5 ROBO1 USH2A IL23R	6.55e-04	185	106	6	SM00060
Domain	HAD-like_dom	ATP13A4 PITPNM1 ATP8A1 LPIN2	1.06e-03	79	106	4	IPR023214
Domain	FN3_dom	PAPPA2 FNDC3A CMYA5 ROBO1 USH2A IL23R	1.23e-03	209	106	6	IPR003961
Domain	fn3	FNDC3A CMYA5 ROBO1 USH2A IL23R	2.31e-03	162	106	5	PF00041
Domain	uDENN	DENND4A DENND2B	2.78e-03	14	106	2	SM00800
Domain	uDENN	DENND4A DENND2B	3.19e-03	15	106	2	PF03456
Domain	DENN	DENND4A DENND2B	3.64e-03	16	106	2	SM00799
Domain	DENN	DENND4A DENND2B	3.64e-03	16	106	2	PF02141
Domain	dDENN	DENND4A DENND2B	3.64e-03	16	106	2	PF03455
Domain	UDENN	DENND4A DENND2B	3.64e-03	16	106	2	PS50946
Domain	DDENN	DENND4A DENND2B	3.64e-03	16	106	2	PS50947
Domain	dDENN	DENND4A DENND2B	3.64e-03	16	106	2	SM00801
Domain	dDENN_dom	DENND4A DENND2B	3.64e-03	16	106	2	IPR005112
Domain	uDENN_dom	DENND4A DENND2B	3.64e-03	16	106	2	IPR005113
Domain	DENN	DENND4A DENND2B	3.64e-03	16	106	2	PS50211
Domain	DENN_dom	DENND4A DENND2B	3.64e-03	16	106	2	IPR001194
Domain	CA	FAT4 PCDHB2 CDH23 FREM2	4.18e-03	115	106	4	SM00112
Domain	Cadherin	FAT4 PCDHB2 CDH23 FREM2	4.58e-03	118	106	4	IPR002126
Domain	FN3	FNDC3A CMYA5 ROBO1 USH2A IL23R	5.55e-03	199	106	5	PS50853
Pubmed	TET1 Interacts Directly with NANOG via Independent Domains Containing Hydrophobic and Aromatic Residues.	NANOGP8 NANOG TET1	1.23e-07	4	110	3	33058869
Pubmed	Endogenous epitope-tagging of Tet1, Tet2 and Tet3 identifies TET2 as a naïve pluripotency marker.	NANOGP8 NANOG TET1	3.06e-07	5	110	3	31582397
Pubmed	The Pluripotency Factor NANOG Binds to GLI Proteins and Represses Hedgehog-mediated Transcription.	NANOGP8 NANOG GLI3	6.11e-07	6	110	3	26797124
Pubmed	Nanog, Oct4 and Tet1 interplay in establishing pluripotency.	NANOGP8 NANOG TET1	6.11e-07	6	110	3	27146218
Pubmed	Expanding the Circuitry of Pluripotency by Selective Isolation of Chromatin-Associated Proteins.	NANOGP8 NANOG TRIM24	1.07e-06	7	110	3	27773674
Pubmed	Identification of Oct4-activating compounds that enhance reprogramming efficiency.	NANOGP8 NANOG TET1	1.07e-06	7	110	3	23213213
Pubmed	Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis.	NANOGP8 NANOG TET1	1.70e-06	8	110	3	26199412
Pubmed	The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner.	WDR6 STK39 OXSR1	1.70e-06	8	110	3	31614064
Pubmed	ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1.	NANOGP8 NANOG TET1	2.55e-06	9	110	3	38237590
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	FOXO3 CDR2 PDE3B DENND4A ACACA RAB11FIP1 DENND2B STIM1 MLXIPL PIK3C2A TET1 MAP3K2 AHNAK2	3.49e-06	861	110	13	36931259
Pubmed	Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.	MASTL STK39 OXSR1	6.63e-06	12	110	3	27782176
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	AKAP6 CAND1 KIAA1549 FNDC3A POGZ NACAD SF3B3 TET1 OXSR1 MAML2	7.34e-06	529	110	10	14621295
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	KANSL1L UBR4 NACAD GLI3 LTK HSF1 CCDC33	9.81e-06	233	110	7	37704626
Pubmed	Enhancing cognitive function in chronic TBI: The Role of α7 nicotinic acetylcholine receptor modulation.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	38070724
Pubmed	Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	34453977
Pubmed	Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	26999808
Pubmed	Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	27129924
Pubmed	Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	23521765
Pubmed	Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	28258105
Pubmed	The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	19344760
Pubmed	Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	29114104
Pubmed	Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	33995108
Pubmed	E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	32552811
Pubmed	Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	24836856
Pubmed	Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	15948184
Pubmed	Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	35678315
Pubmed	Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	12628457
Pubmed	Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	25157794
Pubmed	Mesenchymal Stem Cells or Interleukin-6 Improve Episodic Memory of Mice Lacking α7 Nicotinic Acetylcholine Receptors.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	31202708
Pubmed	Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	22246862
Pubmed	Activation of Nicotinic Acetylcholine Receptors Decreases Apoptosis in Human and Female Murine Pancreatic Islets.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	27471776
Pubmed	Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	22688057
Pubmed	Different Effects of Nicotine and N-Stearoyl-ethanolamine on Episodic Memory and Brain Mitochondria of α7 Nicotinic Acetylcholine Receptor Knockout Mice.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	32028688
Pubmed	Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	30429582
Pubmed	A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neurons.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	21501254
Pubmed	Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	21368056
Pubmed	Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.	STK39 OXSR1	9.91e-06	2	110	2	24191005
Pubmed	Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	1400473
Pubmed	Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood-Brain Barrier Permeability following Experimental Traumatic Brain Injury.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	26937017
Pubmed	Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.	STK39 OXSR1	9.91e-06	2	110	2	16382158
Pubmed	Diminished α7 nicotinic acetylcholine receptor (α7nAChR) rescues amyloid-β induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated mitochondrial oxidative stress.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	36603528
Pubmed	Activation of α7nAChR Promotes Diabetic Wound Healing by Suppressing AGE-Induced TNF-α Production.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	26650489
Pubmed	Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	22848433
Pubmed	Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	16650968
Pubmed	Microglial cell response in α7 nicotinic acetylcholine receptor-deficient mice after systemic infection with Escherichia coli.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	35413868
Pubmed	Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	24462939
Pubmed	Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	29261717
Pubmed	Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous mice.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	18199426
Pubmed	Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	22490926
Pubmed	Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	23270857
Pubmed	Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	18077004
Pubmed	Smoking in adult attention-deficit/hyperactivity disorder: interaction between 15q13 nicotinic genes and Temperament Character Inventory scores.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	19462340
Pubmed	Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	16923147
Pubmed	NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	11790782
Pubmed	Genetic deletion of α7 nAChRs reduces hippocampal granule and pyramidal cell number in both sexes but impairs pattern separation in males only.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	37746145
Pubmed	A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	19631623
Pubmed	Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	15770102
Pubmed	Cortical synaptic NMDA receptor deficits in α7 nicotinic acetylcholine receptor gene deletion models: implications for neuropsychiatric diseases.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	24326163
Pubmed	Functional role of alpha7 nicotinic receptor in chronic neuropathic and inflammatory pain: studies in transgenic mice.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	23811428
Pubmed	Alpha 7 subunit of nAChR regulates migration of human mesenchymal stem cells.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	20720594
Pubmed	Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	17019565
Pubmed	Dilinoleoylphosphatidylcholine ameliorates scopolamine-induced impairment of spatial learning and memory by targeting alpha7 nicotinic ACh receptors.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	19100751
Pubmed	Activation of the α7 Nicotinic Acetylcholine Receptor Prevents against Microglial-Induced Inflammation and Insulin Resistance in Hypothalamic Neuronal Cells.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	35883638
Pubmed	Functional evidence that the self-renewal gene NANOG regulates human tumor development.	NANOGP8 NANOG	9.91e-06	2	110	2	19415763
Pubmed	Chrna7 genotype is linked with alpha7 nicotinic receptor expression but not alpha7 RNA levels.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	19368846
Pubmed	Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	15009674
Pubmed	Hydroxynorketamine, but not ketamine, acts via α7 nicotinic acetylcholine receptor to control presynaptic function and gene expression.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	38253622
Pubmed	The role of dorsal root ganglia alpha-7 nicotinic acetylcholine receptor in complete Freund's adjuvant-induced chronic inflammatory pain.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	34514543
Pubmed	α7 nicotinic acetylcholine receptor (α7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	22183893
Pubmed	Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	9364063
Pubmed	Evidence suggesting that the mouse sperm acrosome reaction initiated by the zona pellucida involves an alpha7 nicotinic acetylcholine receptor.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	12606407
Pubmed	Genetic variations in CHRNA7 or CHRFAM7 and susceptibility to dementia.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	22300029
Pubmed	GTS-21 ameliorates polymicrobial sepsis-induced hepatic injury by modulating autophagy through α7nAchRs in mice.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	32018068
Pubmed	CHRNA7 and CHRFAM7A mRNAs: co-localized and their expression levels altered in the postmortem dorsolateral prefrontal cortex in major psychiatric disorders.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	26206074
Pubmed	Nicotine elicits prolonged calcium signaling along ventral hippocampal axons.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	24349346
Pubmed	The role of nicotinic acetylcholine receptor (nAChR) α7 subtype in the functional interaction between nicotine and ethanol in mouse cerebellum.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	21143250
Pubmed	Cholinergic modulation of appetite-related synapses in mouse lateral hypothalamic slice.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	16319313
Pubmed	Impaired synaptic plasticity in the visual cortex of mice lacking α7-nicotinic receptor subunit.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	25797465
Pubmed	Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	29197398
Pubmed	Cholinergic signaling via the α7 nicotinic acetylcholine receptor regulates the migration of monocyte-derived macrophages during acute inflammation.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	38178134
Pubmed	In hippocampal oriens interneurons anti-Hebbian long-term potentiation requires cholinergic signaling via α7 nicotinic acetylcholine receptors.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	23325242
Pubmed	Glutamatergic synapse formation is promoted by α7-containing nicotinic acetylcholine receptors.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	22649244
Pubmed	Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	17898229
Pubmed	Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	21901321
Pubmed	Dopamine release in prefrontal cortex in response to beta-amyloid activation of alpha7 * nicotinic receptors.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	17935702
Pubmed	Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	20624304
Pubmed	Cytokine-induced alterations of α7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	21784975
Pubmed	Lack of acetylcholine nicotine alpha 7 receptor suppresses development of collagen-induced arthritis and adaptive immunity.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	20659128
Pubmed	Stimulation of α7 nicotinic acetylcholine receptor by nicotine increases suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	20843956
Pubmed	Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	10800961
Pubmed	Characterization of allelic variants at chromosome 15q14 in schizophrenia.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	16417613
Pubmed	Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	11834293
Pubmed	Reduced Chrna7 expression in mice is associated with decreases in hippocampal markers of inhibitory function: implications for neuropsychiatric diseases.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	22314319
Pubmed	Antagonism of Cerebral High Mobility Group Box 1 Ameliorates Dendritic Cell Dysfunction in Sepsis.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	34512319
Pubmed	Visual acuity is reduced in alpha 7 nicotinic receptor knockout mice.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	22281823
Pubmed	Activation of α7-nAChRs Promotes the Clearance of α-Synuclein and Protects Against Apoptotic Cell Death Induced by Exogenous α-Synuclein Fibrils.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	33718373
Pubmed	Nicotinic receptor involvement in regulation of functions of mouse neutrophils from inflammatory site.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	26965141
Pubmed	A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	27676657
Pubmed	Central role of alpha7 nicotinic receptor in differentiation of the stratified squamous epithelium.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	12391028
Pubmed	Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice.	CHRNA7 CHRFAM7A	9.91e-06	2	110	2	25365546
Interaction	DDB1 interactions	CAND1 NANOG FNDC3A STING1 HUWE1 STRIP1 MLXIPL ASXL3 TET1 STK39 OXSR1 HSF1 DYNC1I2 MYB	1.54e-05	697	105	14	int:DDB1
Interaction	LNPK interactions	PDE3B CAND1 ZFYVE27 FNDC3A STING1 NACAD PITPNM1 STIM1 NBAS NOC4L	1.66e-05	355	105	10	int:LNPK
Interaction	DHFR2 interactions	PDE3B FNDC3A HUWE1 STIM1 NBAS SF3B3 PIK3C2A WDR6 STK39	2.04e-05	289	105	9	int:DHFR2
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND4A DENND2B DENND6B	1.25e-04	25	71	3	504
CoexpressionAtlas	dev gonad_e11.5_M_GonadVasMes_Flk_top-relative-expression-ranked_1000	PAPPA2 ACACA TRPC6 MUC16 TRIM24 DENND2B STIM1 HMCN1 ASXL3 GLI3 MASTL ROBO1 STK39 SPIDR KLHL4	1.20e-05	827	104	15	gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_1000
CoexpressionAtlas	dev gonad_e12.5_F_VasAssMesen_MafB_top-relative-expression-ranked_500	PAPPA2 FAT4 TRPC6 MUC16 TRIM24 DENND2B HMCN1 ASXL3 STK39 SPIDR	2.10e-05	388	104	10	gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_500
CoexpressionAtlas	dev gonad_e11.5_M_GonadVasMes_Flk_top-relative-expression-ranked_500	PAPPA2 TRPC6 MUC16 DENND2B HMCN1 ASXL3 GLI3 ROBO1 SPIDR KLHL4	3.95e-05	418	104	10	gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_500
CoexpressionAtlas	dev gonad_e11.5_F_GonadVasMes_Flk_top-relative-expression-ranked_1000	PAPPA2 FAT4 TRPC6 MUC16 TRIM24 DENND2B HMCN1 ASXL3 GLI3 MASTL ROBO1 STK39 SPIDR KLHL4	5.36e-05	831	104	14	gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_1000
CoexpressionAtlas	dev gonad_e11.5_F_SupCellPrec_Sry_top-relative-expression-ranked_1000	REC8 KANSL1L FAT4 MUC16 TRIM24 DENND2B STIM1 HMCN1 CLYBL PIK3C2A CTNNA3 STK39 SPIDR	1.30e-04	791	104	13	gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_1000
CoexpressionAtlas	dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_top-relative-expression-ranked_1000	PAPPA2 FAT4 MUC16 ZFP69 DENND2B STIM1 FREM2 HMCN1 ASXL3 GLI3 STK39 SPIDR NOS1	1.40e-04	797	104	13	gudmap_dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_1000
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_top-relative-expression-ranked_1000	PAPPA2 FAT4 TRPC6 MUC16 STING1 DENND2B STIM1 FREM2 HMCN1 CLYBL ASXL3 GLI3 STK39	1.40e-04	797	104	13	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_1000
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	REC8 DENND4A KIAA1549 BEST3 MLXIPL PIK3C2A NECAB1 PHACTR1	1.16e-08	174	109	8	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP13A4 FAT4 FREM2 HMCN1 ASXL3 ROBO1 USH2A	3.58e-07	184	109	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP13A4 FAT4 FREM2 HMCN1 ASXL3 ROBO1 USH2A	3.58e-07	184	109	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP13A4 FAT4 FREM2 HMCN1 ASXL3 ROBO1 USH2A	3.58e-07	184	109	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 KANSL1L ATP13A4 CDR2 MAML2 NEK11 PHACTR1	5.11e-07	194	109	7	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	KANSL1L ATP13A4 ACACA ATP8A1 STK39 MAML2 SPIDR	5.48e-07	196	109	7	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRPC6 CMYA5 F5 NECAB1 ROBO1 ENPEP	3.65e-06	168	109	6	315ca578c945aeeb77acda2727f3e6db8b43f43e
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3B KIAA1549 FNDC3A FREM2 ASXL3 PHACTR1	5.26e-06	179	109	6	d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ATP13A4 ACACA FREM2 ATP8A1 NECAB1 PHACTR1	5.97e-06	183	109	6	6847c1252d6bb105524f812658112517fd351eab
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	AKAP6 FNDC3A CMYA5 CTNNA3 HOOK2 PHACTR1	7.18e-06	189	109	6	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ATP13A4 ACACA FREM2 ATP8A1 NECAB1 PHACTR1	7.62e-06	191	109	6	a0332a4ef629510fb313ec119195c44a3f704a80
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ATP13A4 ACACA FREM2 ATP8A1 NECAB1 PHACTR1	7.62e-06	191	109	6	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Artery\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FAT4 PDE3B F5 ARAP3 HMCN1 NECAB1	7.62e-06	191	109	6	4b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCell	Epithelial-alveolar_epithelial_cell_type_2\|World / Lineage, Cell type, age group and donor	ATP13A4 ACACA FREM2 ATP8A1 NECAB1 PHACTR1	7.85e-06	192	109	6	58c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCell	Control-Endothelial-Endothelial-Gen_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FAT4 PDE3B ARAP3 HMCN1 KLHL4 PHACTR1	8.09e-06	193	109	6	e1d546165dcc2392f540162206852c4717d7306f
ToppCell	Fetal_29-31_weeks-Epithelial\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ATP13A4 RAB11FIP1 FREM2 ATP8A1 CTNNA3 PHACTR1	8.09e-06	193	109	6	a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 OVCH1 ARAP3 HMCN1 ROBO1 PHACTR1	8.83e-06	196	109	6	e224338490691d92c1f70b57112fabdcc92b06a9
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ATP13A4 ACACA FREM2 ATP8A1 NECAB1 PHACTR1	9.36e-06	198	109	6	f948391296c261c473d339069a6d0f20ccd6f38f
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	KANSL1L ATP13A4 ACACA ATP8A1 MAML2 SPIDR	9.36e-06	198	109	6	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ATP13A4 ACACA FREM2 ATP8A1 NECAB1 PHACTR1	9.63e-06	199	109	6	725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ATP13A4 ACACA FREM2 ATP8A1 NECAB1 PHACTR1	9.63e-06	199	109	6	8587bd98de7767a575088afbea07a1feb4516b9b
ToppCell	Mesenchymal\|World / Lineage, Cell type, age group and donor	FAT4 TRPC6 HMCN1 GLI3 ROBO1 ENPEP	9.63e-06	199	109	6	4bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCell	LV-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	AKAP6 CMYA5 CTNNA3 HOOK2 PHACTR1	1.71e-05	130	109	5	a3e12984fb61311e49cc76c59f74f4dffc48faa1
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Diffuse-7\|TCGA-Stomach / Sample_Type by Project: Shred V9	AKAP6 CMYA5 NECAB1 CTNNA3 KLHL4	2.05e-05	135	109	5	451e90c154e26ae4f72269d6765e7ef51d67313a
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	KANSL1L UBR4 STRIP1 ASXL3 MAML2	3.30e-05	149	109	5	768877bade04ca0321593b8470b5011ad8270431
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	LMNTD2 RAB11FIP1 F5 HMCN1	3.47e-05	75	109	4	3167beedef7304697e9577270cdeacfc9743cee1
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	LMNTD2 RAB11FIP1 F5 HMCN1	3.47e-05	75	109	4	70c346f92a9ac7e33fc1b9dee1dca0bf9ae0a38c
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	LMNTD2 RAB11FIP1 F5 HMCN1	3.47e-05	75	109	4	26d6e54ed0a6c3ff57f6269c460177bc7b8bf979
ToppCell	Adult-Epithelial-basal_cell-D122\|Adult / Lineage, Cell type, age group and donor	TRPC6 CMYA5 HMCN1 ASXL3 CTNNA3	3.86e-05	154	109	5	38d346402417960044ae999e61f0092b46f2b591
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TRPC6 F5 PASD1 NECAB1 ENPEP	3.98e-05	155	109	5	90e629681a72baacc7981b82883866a487638dbc
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TRPC6 F5 PASD1 NECAB1 ENPEP	3.98e-05	155	109	5	e7f49e2fdaf184fa6b4e685518004e7deff1316d
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TRPC6 F5 PASD1 NECAB1 ENPEP	3.98e-05	155	109	5	5a872ca70ae8c30b57f45a6772d7bf565e0c2663
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-Plasma_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PCDHB2 ZXDA UBE2T LTK BRSK1	4.36e-05	158	109	5	0c9bb7f8d080a052ca71701544a076c6c2ea67cd
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-Plasma_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PCDHB2 ZXDA UBE2T LTK BRSK1	4.36e-05	158	109	5	cebb58878b6945074bc1c7d5848d842da5dcbae1
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PCDHB2 ZXDA UBE2T LTK BRSK1	4.36e-05	158	109	5	2cfa6dd36c8ae534cf1dd49366d4b4433388c1e0
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____proximal_tube_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACACA LPIN2 DENND6B MAML2 ENPEP	4.36e-05	158	109	5	1d78578dc1f8ba43dacdccae1082c0b9d749f64d
ToppCell	(08)_PNEC-(1)_24hpi\|(08)_PNEC / shred by cell type and Timepoint	ACACA NACAD DYNC1I2	4.83e-05	29	109	3	f1b59a0b6bce5772bfb084f08507cf775e7eae8c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRPC6 CMYA5 F5 NECAB1 ENPEP	5.84e-05	168	109	5	fc80e4fecfc92458eb627013a983041d8ca025a9
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRPC6 CMYA5 F5 NECAB1 ENPEP	5.84e-05	168	109	5	e96859dbf51cf8c4def8ee8db132f4d874fb4381
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	F5 MLXIPL UBE2T MASTL POLQ	6.18e-05	170	109	5	7534ac69ca3a378df78d61c284e89bc96a71a4a8
ToppCell	BL-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ATP6V1B1 FAT4 BEST3 NACAD ROBO1	6.18e-05	170	109	5	b465df2dac6b4e98b4ede6ad0c6347656757885c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRPC6 F5 NECAB1 ROBO1 ENPEP	6.53e-05	172	109	5	6c17a1e586a72d1bd80c20c06370429c61dc9f85
ToppCell	COVID-19-kidney-Podocyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TRPC6 F5 NECAB1 IL17RD ENPEP	7.08e-05	175	109	5	a73e3a65fd5c1e09cb0c2dae20c1a7bfcae49223
ToppCell	E16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DENND4A CDH23 F5 LPIN2 NPAS4	7.47e-05	177	109	5	84591e28482ab62a5ef41e61043eb64912766356
ToppCell	severe-Myeloid-Neutrophils_1\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	FOXO3 PDE3B ARAP3 MAML2 PHACTR1	7.47e-05	177	109	5	d1ad35ee3d2a84b1d01126d0a38464ab858c00d0
ToppCell	E16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DENND4A CDH23 F5 LPIN2 NPAS4	7.47e-05	177	109	5	4bc100062891d07cacd10ffba38966cc6302c92f
ToppCell	E16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DENND4A CDH23 F5 LPIN2 NPAS4	7.47e-05	177	109	5	9f3a2adb9cd4f0a059afc87b6e377a9702154bb1
ToppCell	droplet-Skin-nan-18m-Lymphocytic-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 SELPLG DENND4A STING1 ARAP3	7.68e-05	178	109	5	12d5c6be6cfbf733e3cb02780606b3725eda7d2b
ToppCell	droplet-Skin-nan-18m-Lymphocytic-T_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 SELPLG DENND4A STING1 ARAP3	7.68e-05	178	109	5	e0769ad06f92423a3cb6c78a61da3ba5bd9b4eae
ToppCell	droplet-Skin-nan-18m-Lymphocytic\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 SELPLG DENND4A STING1 ARAP3	7.68e-05	178	109	5	11c2ce093b7538518c8d4497dc5b0b4da22bf1a8
ToppCell	RA-11._Adipocyte\|RA / Chamber and Cluster_Paper	PDE3B ACACA STIM1 MLXIPL HOOK2	8.09e-05	180	109	5	d48a3d27357f7d184132a6805950f93080146b59
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	ACACA FREM2 ATP8A1 NECAB1 PHACTR1	8.09e-05	180	109	5	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	RV\|World / Chamber and Cluster_Paper	AKAP6 CMYA5 CTNNA3 HOOK2 PHACTR1	8.30e-05	181	109	5	bbe1e6e59d8889bd37d6e8303116cbdcafca7236
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRPC6 CMYA5 F5 NECAB1 ENPEP	8.75e-05	183	109	5	eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRPC6 F5 NECAB1 ROBO1 ENPEP	8.75e-05	183	109	5	7c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	AKAP6 CMYA5 CTNNA3 HOOK2 PHACTR1	8.97e-05	184	109	5	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PAPPA2 TRPC6 F5 CTNNA3 ENPEP	9.20e-05	185	109	5	35d39a1d04c871edcfb749653538dc5fd0054281
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	AKAP6 CMYA5 CTNNA3 HOOK2 PHACTR1	9.20e-05	185	109	5	6baccb26f999145e51b91d94315bf8d4655bef31
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ATP13A4 FREM2 ATP8A1 STK39 PHACTR1	9.44e-05	186	109	5	2ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CDR2 FREM2 NECAB1 MAML2 NEK11	9.44e-05	186	109	5	5c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ATP13A4 RAB11FIP1 MLXIPL CTNNA3 PHACTR1	9.68e-05	187	109	5	4ae7465174e0295d2c3b614b321a3b2f514dd22a
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ATP13A4 FREM2 ATP8A1 NECAB1 PHACTR1	9.68e-05	187	109	5	5df9e1f5ca32217af255e76e6fb5afa346337811
ToppCell	pdx-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	FNDC3A FREM2 PIK3C2A IL17RD CCDC33	9.68e-05	187	109	5	7e376831a11ee72ed87abcdac631ca46ae29c250
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AKAP6 FREM2 CTNNA3 NPAS4 AHNAK2	9.68e-05	187	109	5	3912bbb610a4a84791e9bda92a2d57a52c31d29e
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	AKAP6 CMYA5 CTNNA3 HOOK2 PHACTR1	9.68e-05	187	109	5	78cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	PDE3B DENND4A HUWE1 ATP8A1 MAP3K2	9.93e-05	188	109	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	AKAP6 CMYA5 CTNNA3 HOOK2 PHACTR1	9.93e-05	188	109	5	0758b474457efa36488e0195f7357100f4b6a090
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ATP13A4 CDR2 SNX29 MAML2 NEK11	9.93e-05	188	109	5	63a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PAPPA2 FOXO3 DENND2B ROBO1 MAML2	9.93e-05	188	109	5	997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCell	RA-11._Adipocyte\|World / Chamber and Cluster_Paper	PDE3B ACACA CDH23 MLXIPL HOOK2	9.93e-05	188	109	5	4dac9d636e5cad4cda540b93d4bfed6b5732c880
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	SNX29 FREM2 PIK3C2A MAML2 IL17RD	9.93e-05	188	109	5	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 HMCN1 STK39 NOS1 PHACTR1	9.93e-05	188	109	5	3cee9916399e2e7580cecbcbb27424a71e7e7ac0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 HMCN1 STK39 NOS1 PHACTR1	1.02e-04	189	109	5	f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	AKAP6 CMYA5 CTNNA3 HOOK2 PHACTR1	1.02e-04	189	109	5	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	HSPCs-Ery_prog.\|HSPCs / Lineage and Cell class	REC8 ARAP3 CLYBL LPIN2 MYB	1.02e-04	189	109	5	37d2c45debed1564a40a1085b8b310c50923b9e7
ToppCell	ASK428-Epithelial-Transformed_epithelium\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	AKAP6 REC8 CMYA5 F5 GLI3	1.02e-04	189	109	5	87189275234b5d59484c58acbb14a09903f2b578
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3B F5 ARAP3 HMCN1 NOS1	1.02e-04	189	109	5	c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCell	Control\|World / Disease state, Lineage and Cell class	FOXO3 CDH23 FNDC3A OXSR1 PHACTR1	1.02e-04	189	109	5	fb8dddd3b901081c6bb9ed6f32dafc5cce5f30be
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	AKAP6 CMYA5 HMCN1 GLI3 ENPEP	1.02e-04	189	109	5	203c80030df08ae112f9ae4043709f455d87ce89
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ATP13A4 FREM2 NECAB1 CTNNA3 PHACTR1	1.04e-04	190	109	5	8aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FOXO3 FAT4 DENND2B ROBO1 MAML2	1.04e-04	190	109	5	1121eb607a984c59fbffe7220837fc178745aa55
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	AKAP6 FNDC3A CMYA5 CTNNA3 PHACTR1	1.04e-04	190	109	5	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	AKAP6 CMYA5 CTNNA3 HOOK2 PHACTR1	1.04e-04	190	109	5	de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FOXO3 FAT4 DENND2B ROBO1 MAML2	1.04e-04	190	109	5	048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TRPC6 HMCN1 CTNNA3 ENPEP NPAS4	1.04e-04	190	109	5	d6b3a92119b210974a32af3fe9875d60eb02761e
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|LV / Chamber and Cluster_Paper	AKAP6 CMYA5 CTNNA3 HOOK2 PHACTR1	1.07e-04	191	109	5	25f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ATP13A4 FREM2 ATP8A1 CTNNA3 PHACTR1	1.07e-04	191	109	5	ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCell	Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|World / Lineage, Cell type, age group and donor	ATP13A4 FREM2 ATP8A1 CTNNA3 PHACTR1	1.07e-04	191	109	5	d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCell	Mesenchymal-vascular_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	TRPC6 HMCN1 CTNNA3 ENPEP NPAS4	1.07e-04	191	109	5	fd89fbc62aa1c73e0f659991e3bd726a0c97bd68
ToppCell	Epithelial\|World / Lineage, Cell type, age group and donor	ATP13A4 ACACA FREM2 ATP8A1 PHACTR1	1.10e-04	192	109	5	499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	AKAP6 CMYA5 CTNNA3 HOOK2 PHACTR1	1.10e-04	192	109	5	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ATP13A4 RAB11FIP1 FREM2 ATP8A1 PHACTR1	1.10e-04	192	109	5	29f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ATP13A4 ACACA FREM2 ATP8A1 NECAB1	1.10e-04	192	109	5	cc9911e182a289779a2612bc213daae5607689e7
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D122\|Adult / Lineage, Cell type, age group and donor	ACACA MLXIPL FREM2 ATP8A1 NECAB1	1.10e-04	192	109	5	06013a07e3a873b1d1c0451643c528593ac32a9c
ToppCell	IPF-Epithelial-Club\|Epithelial / Disease state, Lineage and Cell class	ATP13A4 ACACA ATP8A1 HMCN1 PHACTR1	1.10e-04	192	109	5	356e7a820b744a0ac87352a8d0e6e8d9fa9ed7d2
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	ATP13A4 ACACA DENND2B ATP8A1 PHACTR1	1.10e-04	192	109	5	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ATP13A4 FREM2 ATP8A1 NECAB1 PHACTR1	1.10e-04	192	109	5	fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FOXO3 DENND4A SNX29 MAML2 SPIDR	1.12e-04	193	109	5	779276e775cb2492e8dd36436295a536084a6415
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	AKAP6 CMYA5 CTNNA3 RNF216 PHACTR1	1.12e-04	193	109	5	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FAT4 PDE3B ARAP3 HMCN1 PHACTR1	1.12e-04	193	109	5	6e1982d089a9de628e6006d23ff78a223fbd9f47
Disease	nicotine dependence (implicated_via_orthology)	TRPC6 CHRNA7 CHRFAM7A	8.63e-06	12	102	3	DOID:0050742 (implicated_via_orthology)
Disease	cognitive disorder (implicated_via_orthology)	CHRNA7 CHRFAM7A	1.76e-04	6	102	2	DOID:1561 (implicated_via_orthology)
Disease	rheumatoid arthritis (biomarker_via_orthology)	CHRNA7 CHRFAM7A	1.76e-04	6	102	2	DOID:7148 (biomarker_via_orthology)
Disease	schizophrenia, intelligence, self reported educational attainment	AKAP6 FOXO3 DENND4A SNX29 CTNNA3 DENND6B MAML2	2.04e-04	346	102	7	EFO_0004337, EFO_0004784, MONDO_0005090
Disease	urate measurement, bone density	AKAP6 ATP6V1B1 CDR2 PDE3B TRPC6 SNX29 ROBO1 MAML2 USH2A	3.01e-04	619	102	9	EFO_0003923, EFO_0004531
Disease	glucose metabolism decline measurement, cingulate cortex measurement	CDH23 PHACTR1	4.19e-04	9	102	2	EFO_0007738, EFO_0009392
Disease	childhood trauma measurement, smoking behaviour measurement	PAPPA2 RAD21L1 CTNNA3	5.12e-04	45	102	3	EFO_0005671, EFO_0007979
Disease	colon cancer (implicated_via_orthology)	NANOGP8 NANOG	6.38e-04	11	102	2	DOID:219 (implicated_via_orthology)
Disease	Behavior Disorders	TRPC6 NOS1	7.64e-04	12	102	2	C0004930
Disease	Mental disorders	TRPC6 NOS1	7.64e-04	12	102	2	C0004936
Disease	Mental Disorders, Severe	TRPC6 NOS1	7.64e-04	12	102	2	C4046029
Disease	Neurobehavioral Manifestations	CHRNA7 NOS1	7.64e-04	12	102	2	C0525041
Disease	Diagnosis, Psychiatric	TRPC6 NOS1	7.64e-04	12	102	2	C0376338
Disease	Mental Retardation, X-Linked Nonsyndromic	HUWE1 CLCN4	9.00e-04	13	102	2	C3501611
Disease	t-tau measurement	ZNF777 F5 MTBP AHNAK2	9.75e-04	126	102	4	EFO_0004760
Disease	retinal layer thickness measurement	FOXO3 NBAS PIK3C2A	1.19e-03	60	102	3	EFO_0600002
Disease	caffeine measurement	STK39 MAML2	1.21e-03	15	102	2	EFO_0021177
Disease	body weight	AKAP6 PAPPA2 FOXO3 HUWE1 TRIM24 NBAS ASXL3 CTNNA3 STK39 NEK11 DYNC1I2 PHACTR1	1.37e-03	1261	102	12	EFO_0004338
Disease	transient cerebral ischemia (implicated_via_orthology)	TRPC6 HSF1 NOS1	1.43e-03	64	102	3	DOID:224 (implicated_via_orthology)
Disease	schizophrenia (implicated_via_orthology)	CHRNA7 CHRFAM7A NOS1	1.71e-03	68	102	3	DOID:5419 (implicated_via_orthology)
Disease	pentachlorophenol measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022071
Disease	parathion measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022070
Disease	potassium chromate measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022072
Disease	mercuric chloride measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022068
Disease	heptachlor epoxide measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022067
Disease	methoxychlor measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022069
Disease	4,6-dinitro-o-cresol measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022053
Disease	2,4,5-trichlorophenol measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022052
Disease	azinphos methyl measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022055
Disease	aldrin measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022054
Disease	dicofol measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022060
Disease	disulfoton measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022062
Disease	dieldrin measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022061
Disease	endrin measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022064
Disease	endosulfan measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022063
Disease	heptachlor measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022066
Disease	ethion measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022065
Disease	chlorpyrifos measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022057
Disease	cadmium chloride measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022056
Disease	diazinon measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022059
Disease	dibutyl phthalate measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0022058
Disease	environmental exposure measurement	MUC16 F5 USH2A	2.09e-03	73	102	3	EFO_0008360
Disease	diet measurement, body mass index	ATP13A4 CMYA5	2.16e-03	20	102	2	EFO_0004340, EFO_0008111
Disease	wellbeing measurement, alcohol consumption measurement	AKAP6 CMYA5 USH2A	2.18e-03	74	102	3	EFO_0007869, EFO_0007878
Disease	DDT metabolite measurement	MUC16 F5 USH2A	2.18e-03	74	102	3	EFO_0007886
Disease	intellectual disability (implicated_via_orthology)	KANSL1L UBR4 POGZ	2.26e-03	75	102	3	DOID:1059 (implicated_via_orthology)
Disease	blood pressure	STK39 PHACTR1	2.61e-03	22	102	2	EFO_0004325
Disease	alcoholic liver disease	ZNF777 GLI3 ROBO1	2.91e-03	82	102	3	EFO_0008573
Disease	Sjogren's syndrome (is_marker_for)	MUC16 IL23R	3.11e-03	24	102	2	DOID:12894 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LSPDPMSSQPALLID	BEST3	606	Q8N1M1
EMFASENSPEPLSLI	ARAP3	716	Q8WWN8
ELMSPEEPLIASQST	CCDC33	211	Q8N5R6
NESISELTMSPTAPE	ATP13A4	1011	Q4VNC1
ISIMESPLESQPLDS	MASTL	576	Q96GX5
LVMTLQSTDPDLPPN	FAT4	3526	Q6V0I7
DPSLPLLELQDIMTS	ACACA	891	Q13085
EPPLSVLTQDSMTVE	CLCN4	606	P51793
DDMLLLAQLSLPSSP	DENND2B	576	P78524
LVLAPSPDVSSEMVL	DENND6B	276	Q8NEG7
NLVEMTPPDSDVTTV	CDH23	786	Q9H251
MAEEPQSVLQLPTSI	ATG12	1	O94817
PADLISLSSSEPQAM	ATP8A1	166	Q9Y2Q0
SPEISEASLMSNLPL	ASXL3	686	Q9C0F0
EIMPATSDSVPLIAQ	CHRNA7	281	P36544
RLPTPTLEMTSNEEE	CFAP91	476	Q7Z4T9
SSLMLPKVESPEEIQ	CLYBL	131	Q8N0X4
SMLESPIQDPDISST	KPNA5	61	O15131
ESMESTPELLLISSL	DENND4A	981	Q7Z401
TSFADTLMVLELAPP	RAD21L1	316	Q9H4I0
ALEPSVPLMVSLEIS	REC8	406	O95072
DLNDNPPELTMSTLI	PCDHB2	341	Q9Y5E7
LMLTLQNDPPSLETG	OXSR1	236	O95747
PSLPMVSLQDEEVTS	KIAA1549	196	Q9HCM3
TSTLNMSQEEPPELT	MUC16	3081	Q8WXI7
EQDFEMSPSSPTLLL	KANSL1L	456	A0AUZ9
DIPTPVLSLSMLSIT	KIAA0100	636	Q14667
PPSITENVTLESLTM	GLI3	1066	P10071
DSSVPSSELSLPLME	IL17RD	666	Q8NFM7
LASLSVMSPNEPSDD	HSFX4	316	A0A1B0GTS1
MELILSTSPAELTLD	NAA80	1	Q93015
QELMTKDTPDSLSPE	HOOK2	151	Q96ED9
EIPDPMEESTTSLVS	KIAA1109	4016	Q2LD37
TVPILPLSLSATDMD	FREM2	576	Q5SZK8
EALLQSMGLTPESPI	DYNC1I2	61	Q13409
LQPSAVSPSVADMLE	C1orf109	126	Q9NX04
ELPPLISESDMHVSQ	CAND1	696	Q86VP6
TQDPDVLNSLLPMEL	LTK	781	P29376
SVTVPDMSLPDLDSS	HSF1	421	Q00613
LMIPSGLPELTSIQD	PIK3C2A	1336	O00443
NMVSDLLTDPSLPPQ	PDE3B	361	Q13370
SDIDNPTLTVMDISP	MAP3K2	331	Q9Y2U5
VSPLPSSMDLLIQDS	NANOG	51	Q9H9S0
SQPIPSMDLHELESI	NEK11	441	Q8NG66
TLMDPSDLSENIQAP	LMNTD2	191	Q8IXW0
NSDLEMPSLTSTPLI	MYB	411	P10242
LPVQEDDSLMSSHPI	ENPEP	446	Q07075
LASLSVMSPNEPSDD	HSFX3	316	A0A1B0GWH4
SSTQLLMPVEPEELG	HUWE1	2796	Q7Z6Z7
ENMSPLEALEPVLSS	NBAS	1806	A2RRP1
EIMPATSDSVPLIAQ	CHRFAM7A	191	Q494W8
LPPQLLADLETSSMF	KLHL4	376	Q9C0H6
SMSLTLQSPPIITLE	HMCN1	4431	Q96RW7
EEFPSIQMPATLLLT	NOS1	1156	P29475
VFLDTMPESPALSLQ	PASD1	271	Q8IV76
SSQLSLPALSEMEPV	PHACTR1	186	Q9C0D0
NELTNISVPPMSDLE	MAML2	311	Q8IZL2
TMLPSFPENILSQEE	NPAS4	341	Q8IUM7
SDPVMLPENITADTL	PAPPA2	1686	Q9BXP8
LLSPLVMPSEVSEVL	BTBD18	571	B2RXH4
MSAETPITLNIDPQD	CTNNA3	1	Q9UI47
TDLMQTTPQESPEIL	GFY	171	I3L273
QLMEVLSVTPTQSPE	CCNDBP1	131	O95273
PSQSLLEEMFLTVPE	CDR2	286	Q01850
MAEHPPLLDTTQILS	FNDC3A	1	Q9Y2H6
LPVPETSLNMSDSLL	POLQ	1476	O75417
LMSPLEDLSLPPSTD	CMYA5	1071	Q8N3K9
TTMLLENDSPSETIP	IL23R	571	Q5VWK5
AEEMSSLTPESSPEL	BRSK1	576	Q8TDC3
SMPEVSIAPLLELTA	NOC4L	461	Q9BVI4
QPTDLSVDSVELTPM	FAM126B	411	Q8IXS8
VEPNSSSLMETNPLE	MTBP	541	Q96DY7
SIVSLMPEDQISPVS	PRR14L	571	Q5THK1
ENTMKTEPTSPLVEL	PHF20	406	Q9BVI0
LMDDLLDNITLPPSQ	FOXO3	386	O43524
ETEPPEMLRNSTDTT	SELPLG	56	Q14242
EALPENMDSPTLQVT	USH2A	4441	O75445
SITQIPILTMPNDDI	ATP6V1B1	341	P15313
LLPSQEESFSEVPMS	RAB11FIP1	886	Q6WKZ4
PLQVLMSNELPETLS	RNF133	316	Q8WVZ7
VPSTSTMSQEPELLI	STING1	351	Q86WV6
LPSASVPESMTISEL	SNX29	456	Q8TEQ0
TSLPTDLNQTLPSMD	F5	1076	P12259
DLSQIPLTPDLDQMT	F5	1396	P12259
PLTPDLDQMTLSPDL	F5	1401	P12259
VSPLPSSMDLLIQDS	NANOGP8	51	Q6NSW7
ILPSPLLAETSEAMV	OVCH1	376	Q7RTY7
ALQEAAPLTSSMDPL	POGZ	711	Q7Z3K3
SINILADVLPEEMPT	STRIP1	541	Q5VSL9
ADVLPEEMPTTVLQS	STRIP1	546	Q5VSL9
PITISDSSDEERIPM	RNF216	31	Q9NWF9
MDPTISTLDTELTPI	MRGPRX1	1	Q96LB2
DEEIVSPLSMQSPSL	STIM1	481	Q13586
LTPLQPSLDDFMDIS	MLXIPL	286	Q9NP71
PTLSAPVMEPLINSE	TET1	1911	Q8NFU7
LTSPQDLASSPMEED	TET1	1946	Q8NFU7
PLSDILSDEESSMPL	AKAP6	716	Q13023
EVTSPNLDVSLPSME	AHNAK2	4416	Q8IVF2
PMQILILTLDPSEGE	SHANK2-AS3	71	Q9BTD1
SLFLEELEMLVPSTP	PITPNM1	781	O00562
LPSLPDIDCSSTIML	TRIM24	621	O15164
PVMLDSLDSATPVNS	SPIDR	761	Q14159
TVLTSIQLLMSEPNP	UBE2T	106	Q9NPD8
ATLTPSPQEELQPML	ROBO1	1261	Q9Y6N7
LTTMLDHDSTVLEPP	WDR6	946	Q9NNW5
IISLDPSDCLQPLSM	SF3B3	616	Q15393
GLMDSTPALTPTEDL	ZFYVE27	256	Q5T4F4
LMATSDPPQSLDTSL	ZXDA	661	P98168
TVVDPSLDQALPEMS	ZNF142	646	P52746
LSLSSEDPVMTALEL	TRPC6	286	Q9Y210
SEITEELPSSQLMPV	ZNF396	156	Q96N95
TLSPTVPETDMDPLL	ZNF777	141	Q9ULD5
VLMLTLQNDPPTLET	STK39	281	Q9UEW8
VTMALDTLSLPVLEP	UBR4	306	Q5T4S7
MPQQLLITLPTEAST	ZFP69	1	Q49AA0
LEPPLESTQISSMLD	LPIN2	346	Q92539
VMTPPLPLQDTELSS	NACAD	641	O15069
LETPELTSTMLVPAS	NECAB1	331	Q8N987