Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentendoplasmic reticulum membrane

SFTPB PIGO PIEZO1 TXNDC11 TMEM132A

2.21e-031293165GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

SFTPB PIGO PIEZO1 TXNDC11 TMEM132A

2.25e-031299165GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

SFTPB PIGO PIEZO1 TXNDC11 TMEM132A

2.48e-031327165GO:0042175
Pubmed

Wnt5a participates in distal lung morphogenesis.

SFTPB SPRY2

1.31e-051216212142021
Pubmed

Geranylgeranyl Diphosphate Synthase Modulates Fetal Lung Branching Morphogenesis Possibly through Controlling K-Ras Prenylation.

SFTPB SPRY2

2.08e-051516227106761
Pubmed

Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation.

SFTPB SPRY2

3.38e-051916218258849
Pubmed

Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in Mice by the FGF Signaling Pathway.

SFTPB SPRY2

8.57e-053016235682694
Pubmed

Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia.

SFTPB SPRY2

9.76e-053216227770432
Pubmed

Lung epithelial branching program antagonizes alveolar differentiation.

SFTPB SPRY2

1.04e-043316224058167
Pubmed

Hox5 Genes Regulate the Wnt2/2b-Bmp4-Signaling Axis during Lung Development.

SFTPB SPRY2

1.24e-043616226235626
Pubmed

Impact of Fgf10 deficiency on pulmonary vasculature formation in a mouse model of bronchopulmonary dysplasia.

SFTPB SPRY2

1.46e-043916230566624
Pubmed

Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development.

SFTPB SPRY2

1.53e-044016232317081
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

PIGO PIEZO1 TXNDC11 DMXL1 TMEM132A

1.55e-04120116535696571
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

CHD2 PIEZO1 TXNDC11 DMXL1 ERVS71-1

1.63e-04121516515146197
Pubmed

Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis.

SFTPB SPRY2

1.86e-044416223620511
Pubmed

Sox9 plays multiple roles in the lung epithelium during branching morphogenesis.

SFTPB SPRY2

2.40e-045016224191021
Pubmed

Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast cell fate.

SFTPB SPRY2

2.60e-045216226984772
CoexpressionMEISSNER_ES_ICP_WITH_H3K4ME3_AND_H3K27ME3

ADAM33 CNMD

2.77e-0514152M1931
CoexpressionMEISSNER_ES_ICP_WITH_H3K4ME3_AND_H3K27ME3

ADAM33 CNMD

2.77e-0514152MM816
CoexpressionMEISSNER_NPC_ICP_WITH_H3_UNMETHYLATED

ADAM33 CNMD

7.68e-0523152M1937
CoexpressionMEISSNER_NPC_ICP_WITH_H3_UNMETHYLATED

ADAM33 CNMD

7.68e-0523152MM821
CoexpressionGSE37416_0H_VS_12H_F_TULARENSIS_LVS_NEUTROPHIL_DN

CHD2 TXNDC11 TBC1D7

1.83e-04199153M5348
Drug2-propylpentanoic acid; Down 200; 50uM; MCF7; HT_HG-U133A

MON2 SFTPB SPRY2 PIGO

7.03e-061981545219_DN
Diseasechronic obstructive pulmonary disease (is_implicated_in)

SFTPB ADAM33

4.63e-0463152DOID:3083 (is_implicated_in)
DiseaseSelf-injurious behavior

CHD2 ACP7

7.08e-0478152HP_0100716
DiseaseLung diseases

SFTPB SPRY2

7.08e-0478152C0024115
Diseaseasthma (is_marker_for)

SFTPB ADAM33

1.83e-03126152DOID:2841 (is_marker_for)
Diseasemean corpuscular hemoglobin concentration

PIGO PIEZO1 PATE2 DMXL1

1.92e-031105154EFO_0004528
Diseasemean reticulocyte volume

PIGO PIEZO1 TXNDC11

7.06e-03799153EFO_0010701
DiseaseLung Neoplasms

SFTPB SPRY2

7.81e-03265152C0024121
DiseaseMalignant neoplasm of lung

SFTPB SPRY2

7.87e-03266152C0242379
Diseaseinsulin measurement

SPRY2 CHD2

7.92e-03267152EFO_0004467

Protein segments in the cluster

PeptideGeneStartEntry
LLPLLPGAGLAWCCY

ADAM33

711

Q9BZ11
WLPTLIPSYCLGAYC

DMXL1

741

Q9Y485
FLLCPYWGELHDPIK

PATE2

11

Q6UY27
MHPLPGYWSCYCLLL

ACP7

1

Q6ZNF0
DCWLCLKAKPPYYVG

ERVS71-1

301

P61550
PPFDCLWLCLYAKLG

MON2

1016

Q7Z3U7
PEYLCKWMGLPYSEC

CHD2

411

O14647
FPIPLPYCWLCRALI

SFTPB

201

P07988
PYGPWLCLLVALALD

TMEM132A

16

Q24JP5
LPYDLWFKRCFAGCL

TBC1D7

201

Q9P0N9
LFLPCLWCYLPAKGC

SPRY2

261

O43597
CEAPCPEDWLLYGRK

CLEC2L

96

P0C7M8
ELCGDLPIFWLKPTY

CNMD

191

O75829
LLLYYAPWCGFCPSL

TXNDC11

711

Q6PKC3
AVGCPLLLLWPFLCE

PIGO

951

Q8TEQ8
CLGMPPALCIDYPWR

PIEZO1

1056

Q92508