Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionolfactory receptor activity

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 OR10A2 OR14C36 OR2T34 OR52M1 OR5M8 OR13C7 OR1I1 OR13C6P OR10J6P OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

7.42e-294313923GO:0004984
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 RXFP1 OR10A2 OR14C36 OR2T34 OR52M1 OR5M8 OR13C7 OR1I1 OR13C6P GPR119 OR10J6P OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

8.55e-258843925GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 RXFP1 OR10A2 OR14C36 OR2T34 OR52M1 OR5M8 OR13C7 OR1I1 OR13C6P GPR119 OR10J6P OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

2.88e-2013533925GO:0004888
GeneOntologyMolecularFunctionodorant binding

OR5A2 OR8K3 OR14C36 OR5M8 OR9Q1 OR8B8

1.61e-07127396GO:0005549
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 OR10A2 OR14C36 OR2T34 OR52M1 OR5M8 OR13C7 OR1I1 OR13C6P OR10J6P OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

1.57e-294323823GO:0050911
GeneOntologyBiologicalProcesssensory perception of smell

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 OR10A2 OR14C36 OR2T34 OR52M1 OR5M8 OR13C7 OR1I1 OR13C6P OR10J6P OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

8.69e-294653823GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 OR10A2 OR14C36 OR2T34 OR52M1 OR5M8 OR13C7 OR1I1 OR13C6P OR10J6P OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

2.31e-284853823GO:0050907
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 OR10A2 OR14C36 OR2T34 OR52M1 PPEF2 OR5M8 OR13C7 OR1I1 OR13C6P OR10J6P OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

2.72e-285823824GO:0050906
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 OR10A2 OR14C36 OR2T34 OR52M1 OR5M8 OR13C7 OR1I1 OR13C6P OR10J6P OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

1.39e-275243823GO:0009593
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 OR10A2 OR14C36 OR2T34 OR52M1 OR5M8 OR13C7 OR1I1 OR13C6P OR10J6P OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

3.74e-275473823GO:0007606
GeneOntologyBiologicalProcessdetection of stimulus

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 OR10A2 OR14C36 OR2T34 OR52M1 PPEF2 OR5M8 OR13C7 OR1I1 OR13C6P OR10J6P OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

4.80e-267223824GO:0051606
GeneOntologyBiologicalProcesssensory perception

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 OR10A2 OR14C36 OR2T34 OR52M1 PPEF2 OR5M8 OR13C7 OR1I1 OR13C6P OR10J6P OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

5.66e-2210723824GO:0007600
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 RXFP1 OR10A2 OR14C36 OR2T34 OR52M1 OR5M8 OR13C7 OR1I1 OR13C6P GPR119 OR10J6P OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

1.06e-2013953825GO:0007186
DomainOlfact_rcpt

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 OR10A2 OR14C36 OR2T34 OR52M1 OR5M8 OR3A4P OR1I1 OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

3.39e-263933721IPR000725
Domain7tm_1

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 RXFP1 OR10A2 OR14C36 OR2T34 OR52M1 OR5M8 OR3A4P OR1I1 GPR119 OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

1.92e-246773723PF00001
DomainG_PROTEIN_RECEP_F1_1

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 RXFP1 OR10A2 OR14C36 OR2T34 OR52M1 OR5M8 OR3A4P OR1I1 GPR119 OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

2.51e-246853723PS00237
DomainG_PROTEIN_RECEP_F1_2

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 RXFP1 OR10A2 OR14C36 OR2T34 OR52M1 OR5M8 OR3A4P OR1I1 GPR119 OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

3.07e-246913723PS50262
DomainGPCR_Rhodpsn

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 RXFP1 OR10A2 OR14C36 OR2T34 OR52M1 OR5M8 OR3A4P OR1I1 GPR119 OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

3.17e-246923723IPR000276
DomainGPCR_Rhodpsn_7TM

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 RXFP1 OR10A2 OR14C36 OR2T34 OR52M1 OR5M8 OR1I1 GPR119 OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

6.46e-236703722IPR017452
DomainEFh

FKBP7 PPEF2 USP32

3.74e-03158373SM00054
DomainEF_Hand_1_Ca_BS

FKBP7 PPEF2 USP32

4.97e-03175373IPR018247
DomainEF_HAND_1

FKBP7 PPEF2 USP32

7.59e-03204373PS00018
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 OR10A2 OR14C36 OR2T34 OR52M1 OR5M8 OR1I1 OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

2.59e-243893120M14091
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 OR10A2 OR14C36 OR2T34 OR52M1 OR5M8 OR1I1 OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

1.05e-234173120M4072
PathwayREACTOME_SENSORY_PERCEPTION

OR2T3 OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 OR10A2 OR14C36 OR2T34 OR52M1 OR5M8 OR1I1 OR13C4 OR9Q1 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

4.85e-206363120M41834
PathwayREACTOME_REGULATION_OF_PTEN_LOCALIZATION

PTEN NEDD4

1.67e-049312M27814
PathwayREACTOME_REGULATION_OF_PTEN_LOCALIZATION

PTEN NEDD4

2.08e-0410312MM15539
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

OR6A2 OR10A2 OR13C7 OR8B8

6.99e-04186314MM15994
Pubmed

The human olfactory receptor gene family.

OR52E4 OR51T1 OR5A2 OR6A2 OR2M5 OR8K3 OR10A2 OR14C36 OR2T34 OR52M1 OR5M8 OR3A4P OR10J6P OR13C4 OR52N4 OR8B8 OR1L4 OR2G2 OR52E2

3.13e-24541401914983052
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR52E4 OR51T1 OR6A2 OR2M5 OR8K3 OR10A2 OR14C36 OR52M1 OR5M8 OR13C7 OR1I1 OR9Q1 OR52N4 OR8B8 OR1L4 OR52E2

2.48e-22340401611875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR52E4 OR51T1 OR6A2 OR2M5 OR8K3 OR10A2 OR14C36 OR52M1 OR5M8 OR13C7 OR1I1 OR9Q1 OR52N4 OR8B8 OR1L4 OR52E2

2.48e-22340401611802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR52E4 OR51T1 OR6A2 OR2M5 OR8K3 OR10A2 OR14C36 OR52M1 OR5M8 OR13C7 OR1I1 OR9Q1 OR52N4 OR8B8 OR1L4 OR52E2

2.86e-22343401632295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR52E4 OR51T1 OR6A2 OR2M5 OR8K3 OR10A2 OR14C36 OR52M1 OR5M8 OR13C7 OR1I1 OR9Q1 OR52N4 OR8B8 OR1L4 OR52E2

3.29e-22346401614611657
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR5A2 OR10A2 OR2T34 OR5M8 OR3A4P OR1I1 OR10J6P OR13C4 OR9Q1 OR8B8 OR1L4

9.44e-16219401112213199
Pubmed

Odorant and vomeronasal receptor genes in two mouse genome assemblies.

OR8K3 OR14C36 OR13C7 OR1I1 OR52N4

2.36e-087440515081110
Pubmed

Organization and evolutionary relatedness of OR37 olfactory receptor genes in mouse and human.

OR13C7 OR13C6P OR13C4

3.08e-071240312906860
Pubmed

Oncogenic role of the E3 ubiquitin ligase NEDD4-1, a PTEN negative regulator, in non-small-cell lung carcinomas.

PTEN NEDD4

1.29e-06240220889565
Pubmed

Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage.

PTEN NEDD4

1.29e-06240233712741
Pubmed

[Nedd4/PTEN in axonal branching].

PTEN NEDD4

1.29e-06240220819705
Pubmed

Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc.

PTEN NEDD4

1.29e-06240220100827
Pubmed

Ubiquitination regulates PTEN nuclear import and tumor suppression.

PTEN NEDD4

1.29e-06240217218261
Pubmed

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.

PTEN NEDD4

1.29e-06240217218260
Pubmed

NEDD4 Depletion Inhibits Hepatocellular Carcinoma Growth via Targeting PTEN.

PTEN NEDD4

1.29e-06240227467187
Pubmed

Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis?

PTEN NEDD4

1.29e-06240223180960
Pubmed

Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non-small-cell lung cancer.

PTEN NEDD4

1.29e-06240228714370
Pubmed

Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation.

PTEN NEDD4

3.87e-06340218498243
Pubmed

ΔNp63α represses nuclear translocation of PTEN by inhibition of NEDD4-1 in keratinocytes.

PTEN NEDD4

3.87e-06340223589096
Pubmed

Possible involvement of NEDD4 in keloid formation; its critical role in fibroblast proliferation and collagen production.

PTEN NEDD4

3.87e-06340221986318
Pubmed

LINC01198 promotes proliferation and temozolomide resistance in a NEDD4-1-dependent manner, repressing PTEN expression in glioma.

PTEN NEDD4

3.87e-06340231469661
Pubmed

PUM2 promoted osteoarthritis progression through PTEN-mediated chondrocyte ferroptosis by facilitating NEDD4 mRNA degradation.

PTEN NEDD4

3.87e-06340238733337
Pubmed

Rak functions as a tumor suppressor by regulating PTEN protein stability and function.

PTEN NEDD4

3.87e-06340219345329
Pubmed

Regulation of PTEN degradation and NEDD4-1 E3 ligase activity by Numb.

PTEN NEDD4

3.87e-06340228437168
Pubmed

The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization.

PTEN NEDD4

7.73e-06440218562292
Pubmed

PTEN phosphorylation and nuclear export mediate free fatty acid-induced oxidative stress.

PTEN NEDD4

7.73e-06440224063548
Pubmed

Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN.

PTEN NEDD4

7.73e-06440225883222
Pubmed

Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state.

PTEN NEDD4

7.73e-06440225047839
Pubmed

The E3 Ubiquitin Ligase NEDD4-1 Mediates Temozolomide-Resistant Glioblastoma through PTEN Attenuation and Redox Imbalance in Nrf2-HO-1 Axis.

PTEN NEDD4

7.73e-06440234638586
Pubmed

YY1-regulated LINC00152 promotes triple negative breast cancer progression by affecting on stability of PTEN protein.

PTEN NEDD4

7.73e-06440230594392
Pubmed

A Tunable Brake for HECT Ubiquitin Ligases.

PTEN NEDD4

1.29e-05540228475870
Pubmed

Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.

PTEN NEDD4

1.29e-05540225157163
Pubmed

Enzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4-1 E3 Ligases.

PTEN NEDD4

1.29e-05540227295432
Pubmed

Semisynthetic Approach to the Analysis of Tumor Suppressor PTEN Ubiquitination.

PTEN NEDD4

1.29e-05540236897111
Pubmed

p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN.

PTEN NEDD4

1.93e-05640224141722
Pubmed

Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth.

PTEN NEDD4

2.70e-05740225547115
Pubmed

Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases.

PTEN NEDD4

3.60e-05840231578285
Pubmed

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis.

PTEN NEDD4

3.60e-05840226280536
Pubmed

Genomic analysis of orthologous mouse and human olfactory receptor loci.

OR6A2 OR10A2

4.62e-05940211416212
Pubmed

The Zonal Organization of Odorant Receptor Gene Choice in the Main Olfactory Epithelium of the Mouse.

OR6A2 OR13C7

4.62e-05940232209480
Pubmed

CK1α suppresses lung tumour growth by stabilizing PTEN and inducing autophagy.

PTEN NEDD4

4.62e-05940229593330
Pubmed

A probabilistic classifier for olfactory receptor pseudogenes.

OR8K3 OR3A4P

7.49e-043540216939646
Pubmed

Personal receptor repertoires: olfaction as a model.

OR8K3 OR13C7

8.83e-043840222908908
InteractionLINC01198 interactions

PTEN NEDD4

4.07e-063242int:LINC01198
Cytoband11p15.4

OR52E4 OR51T1 OR10A2 OR52M1 OR52N4 OR52E2

2.15e-0820040611p15.4
Cytoband1q44

OR2T3 OR2M5 OR14C36 OR2T34 OR2G2

4.43e-081104051q44
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR2T3 OR2M5 OR14C36 OR2T34 OR2G2

9.48e-08128405chr1q44
CytobandEnsembl 112 genes in cytogenetic band chr11p15

OR52E4 OR51T1 OR6A2 OR10A2 OR52M1 OR52N4 OR52E2

5.34e-07564407chr11p15
Cytoband11q12.1

OR5A2 OR8K3 OR5M8 OR9Q1

1.21e-0516140411q12.1
CytobandEnsembl 112 genes in cytogenetic band chr11q12

OR5A2 OR8K3 OR5M8 OR9Q1

2.31e-04345404chr11q12
Cytoband9p13.3

OR13C7 OR13C6P

1.97e-03754029p13.3
GeneFamilyOlfactory receptors, family 52

OR52E4 OR52M1 OR52N4 OR52E2

2.94e-0649374165
GeneFamilyOlfactory receptors, family 13

OR13C7 OR13C6P OR13C4

1.36e-0523373162
GeneFamilyOlfactory receptors, family 2

OR2T3 OR2M5 OR2T34 OR2G2

8.15e-05113374149
GeneFamilyOlfactory receptors, family 1

OR1I1 OR1L4

3.03e-0340372147
GeneFamilyOlfactory receptors, family 8

OR8K3 OR8B8

4.51e-0349372155
GeneFamilyOlfactory receptors, family 10

OR10A2 OR10J6P

8.05e-0366372157
GeneFamilyEF-hand domain containing

FKBP7 PPEF2 USP32

1.01e-02219373863
GeneFamilyOlfactory receptors, family 5

OR5A2 OR5M8

2.20e-02112372152
Diseasetuberculosis

CFAP54 VWA8 NEDD4

1.64e-03216323MONDO_0018076
DiseaseInsulin Sensitivity

STS PTEN

1.94e-0360322C0920563
DiseaseInsulin Resistance

STS PTEN

1.94e-0360322C0021655
DiseaseDystonia

SLC19A3 PTEN

3.93e-0386322C0013421
DiseaseFatty Liver

STS PTEN

4.12e-0388322C0015695
DiseaseSteatohepatitis

STS PTEN

4.12e-0388322C2711227

Protein segments in the cluster

PeptideGeneStartEntry
YKPLASNSFMMDLHL

CFAP54

771

Q96N23
LFSMYFHMTLSFLGQ

ACER1

71

Q8TDN7
AFMYLKPFSLLAMNQ

OR8B8

256

Q15620
LYFMMFLKSFLPLKT

SDR16C5

271

Q8N3Y7
SLHQPMFYFLAMLAT

OR52E2

56

Q8NGJ4
SLHQPMFYFLAMLSM

OR52E4

56

Q8NGH9
HMPMYFFLGNLSFLD

OR13C4

56

Q8NGS5
LHMPMYFFLGNLSFL

OR13C6P

56

Q8NH95
LHMPMYFFLGNLSFL

OR13C7

56

P0DN81
PKLHMPMYFFLSHLS

OR2G2

56

Q8NGZ5
ALHKPMYYFLAMLSF

OR52N4

56

Q8NGI2
HAPMYFLLSHLAFMD

OR9Q1

56

Q8NGQ5
LDGFFIRPFYKMMLH

NEDD4

1071

P46934
SSLHMPMYFFLRNLS

OR14C36

51

Q8NHC7
HTPMYFLLSQLFLMD

OR2M5

56

A3KFT3
RLHKPMYYFLSMLAA

OR51T1

56

Q8NGJ9
AILMETKLHSPMYFF

OR3A4P

51

P47883
LHMPMYFFLSNLSFL

OR5A2

56

Q8NGI9
PAMLLFVFFYCDMLK

GPR119

176

Q8TDV5
MYAFHLFGTMDSFLL

OR1I1

101

O60431
HTPMYFFISQLALMD

OR2T34

61

Q8NGX1
HTPMYFFISQLALMD

OR2T3

61

Q8NH03
MLHSPMYFFLRNLSF

OR10A2

41

Q9H208
MPKTMHFLFRFIVFF

FKBP7

1

Q9Y680
FSLFLPMPKKSMFFH

SLC19A3

186

Q9BZV2
MILFAFMLVYPKEFH

PPEF2

221

O14830
LDYRPVALLFHKMMF

PTEN

186

P60484
LHKPMYFFLANMSFL

OR6A2

56

O95222
LHTPMYFFLSNLSFM

OR1L4

56

Q8NGR5
HTPMYFFLSMLASSK

OR10J6P

56

Q8NGY7
SLHQPMYFFLCMLAA

OR52M1

56

Q8NGK5
LLMVKMGHFFYTLPN

SLC26A8

441

Q96RN1
LGFLHYFRPLNCFMM

STS

231

P08842
MPMYFFLSHLSFVDL

OR5M8

56

Q8NGP6
QTPMYFFLRHLAFMD

OR8K3

56

Q8NH51
RMFRPLMNLSHIYFK

RXFP1

361

Q9HBX9
KMSAYNLALMFAPHV

ARHGAP19

261

Q14CB8
YPHNLMTFQMKFFYI

TRAM1

156

Q15629
TMFFFHYMKPLVKSE

VWA8

601

A3KMH1
FNFLSLPLPMDSYMH

USP32

906

Q8NFA0