Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sphingosine N-acyltransferase activity	CERS2 CERS5 CERS1 CERS3	2.76e-10	7	35	4	GO:0050291
GeneOntologyMolecularFunction	valine-tRNA ligase activity	VARS2 VARS1	2.98e-06	2	35	2	GO:0004832
GeneOntologyMolecularFunction	G-protein activated inward rectifier potassium channel activity	KCNJ5 KCNJ9	1.79e-05	4	35	2	GO:0015467
GeneOntologyMolecularFunction	N-acyltransferase activity	CERS2 CERS5 CERS1 CERS3	2.97e-05	102	35	4	GO:0016410
GeneOntologyMolecularFunction	acyltransferase activity, transferring groups other than amino-acyl groups	CERS2 CERS5 CERS1 HHAT CERS3	5.59e-05	238	35	5	GO:0016747
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	DEGS2 SCD5	2.30e-04	13	35	2	GO:0016717
GeneOntologyMolecularFunction	aminoacyl-tRNA editing activity	VARS2 VARS1	2.68e-04	14	35	2	GO:0002161
GeneOntologyMolecularFunction	transporter activity	ANO4 LRRC8B SEC63 ABCB9 RHBDF2 KCNJ5 PLEKHA8 KCNJ9 KCNK10	2.89e-04	1289	35	9	GO:0005215
GeneOntologyMolecularFunction	acyltransferase activity	CERS2 CERS5 CERS1 TRIM4 HHAT RNF146 CERS3	3.36e-04	775	35	7	GO:0016746
GeneOntologyMolecularFunction	voltage-gated potassium channel activity	KCNJ5 KCNJ9 KCNK10	7.52e-04	102	35	3	GO:0005249
GeneOntologyMolecularFunction	inward rectifier potassium channel activity	KCNJ5 KCNJ9	1.10e-03	28	35	2	GO:0005242
GeneOntologyMolecularFunction	monoatomic ion channel activity	ANO4 LRRC8B KCNJ5 KCNJ9 KCNK10	1.15e-03	459	35	5	GO:0005216
GeneOntologyMolecularFunction	potassium channel activity	KCNJ5 KCNJ9 KCNK10	1.45e-03	128	35	3	GO:0005267
GeneOntologyMolecularFunction	phosphatidylinositol-4-phosphate binding	PLEKHA8 PLEKHA3	1.81e-03	36	35	2	GO:0070273
GeneOntologyMolecularFunction	channel activity	ANO4 LRRC8B KCNJ5 KCNJ9 KCNK10	2.08e-03	525	35	5	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	ANO4 LRRC8B KCNJ5 KCNJ9 KCNK10	2.10e-03	526	35	5	GO:0022803
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	KCNJ5 KCNJ9 KCNK10	2.37e-03	152	35	3	GO:0022843
GeneOntologyMolecularFunction	aminoacyl-tRNA ligase activity	VARS2 VARS1	2.46e-03	42	35	2	GO:0004812
GeneOntologyMolecularFunction	ligase activity, forming carbon-oxygen bonds	VARS2 VARS1	2.46e-03	42	35	2	GO:0016875
GeneOntologyMolecularFunction	protein transporter activity	SEC63 RHBDF2	2.46e-03	42	35	2	GO:0140318
GeneOntologyMolecularFunction	gated channel activity	ANO4 KCNJ5 KCNJ9 KCNK10	2.67e-03	334	35	4	GO:0022836
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	KCNJ5 KCNJ9 KCNK10	3.09e-03	167	35	3	GO:0015079
GeneOntologyMolecularFunction	glycolipid binding	GPAA1 PLEKHA8	3.33e-03	49	35	2	GO:0051861
GeneOntologyMolecularFunction	ligase activity	VARS2 TTLL8 VARS1	3.47e-03	174	35	3	GO:0016874
GeneOntologyMolecularFunction	transmembrane transporter activity	ANO4 LRRC8B SEC63 ABCB9 KCNJ5 KCNJ9 KCNK10	3.87e-03	1180	35	7	GO:0022857
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	KCNJ5 KCNJ9 KCNK10	3.93e-03	182	35	3	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	KCNJ5 KCNJ9 KCNK10	4.06e-03	184	35	3	GO:0022832
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	ANO4 KCNJ5 KCNJ9	4.63e-03	193	35	3	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	ANO4 KCNJ5 KCNJ9	4.91e-03	197	35	3	GO:0022834
GeneOntologyMolecularFunction	phospholipid transporter activity	ANO4 PLEKHA8	7.45e-03	74	35	2	GO:0005548
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	ANO4 LRRC8B KCNJ5 KCNJ9 KCNK10	1.18e-02	793	35	5	GO:0015075
GeneOntologyMolecularFunction	monoatomic anion channel activity	ANO4 LRRC8B	1.40e-02	103	35	2	GO:0005253
GeneOntologyMolecularFunction	ATPase binding	NKAIN1 TMTC4	1.54e-02	108	35	2	GO:0051117
GeneOntologyBiologicalProcess	ceramide biosynthetic process	CERS2 CERS5 DEGS2 CERS1 CERS3	1.06e-07	73	33	5	GO:0046513
GeneOntologyBiologicalProcess	membrane lipid biosynthetic process	CERS2 CERS5 DEGS2 CERS1 GPAA1 CERS3	1.65e-07	157	33	6	GO:0046467
GeneOntologyBiologicalProcess	ceramide metabolic process	CERS2 CERS5 DEGS2 CERS1 CERS3	9.48e-07	113	33	5	GO:0006672
GeneOntologyBiologicalProcess	sphingolipid biosynthetic process	CERS2 CERS5 DEGS2 CERS1 CERS3	1.13e-06	117	33	5	GO:0030148
GeneOntologyBiologicalProcess	membrane lipid metabolic process	CERS2 CERS5 DEGS2 CERS1 GPAA1 CERS3	1.51e-06	229	33	6	GO:0006643
GeneOntologyBiologicalProcess	valyl-tRNA aminoacylation	VARS2 VARS1	2.48e-06	2	33	2	GO:0006438
GeneOntologyBiologicalProcess	amide biosynthetic process	CERS2 CERS5 DEGS2 CERS1 CERS3	7.47e-06	172	33	5	GO:0043604
GeneOntologyBiologicalProcess	sphingolipid metabolic process	CERS2 CERS5 DEGS2 CERS1 CERS3	8.36e-06	176	33	5	GO:0006665
GeneOntologyBiologicalProcess	lipid biosynthetic process	PI4K2A CERS2 CERS5 DEGS2 CERS1 GPAA1 SCD5 CERS3	3.25e-05	813	33	8	GO:0008610
GeneOntologyBiologicalProcess	aminoacyl-tRNA metabolism involved in translational fidelity	VARS2 VARS1	1.91e-04	13	33	2	GO:0106074
GeneOntologyBiologicalProcess	regulation of translational fidelity	VARS2 VARS1	4.17e-04	19	33	2	GO:0006450
GeneOntologyCellularComponent	endoplasmic reticulum membrane	CERS2 CERS5 LRRC8B DEGS2 G6PC2 CERS1 GPAA1 SCD5 SEC63 ABCB9 RHBDF2 HHAT CERS3	7.49e-08	1293	35	13	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	CERS2 CERS5 LRRC8B DEGS2 G6PC2 CERS1 GPAA1 SCD5 SEC63 ABCB9 RHBDF2 HHAT CERS3	7.91e-08	1299	35	13	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	CERS2 CERS5 LRRC8B DEGS2 G6PC2 CERS1 GPAA1 SCD5 SEC63 ABCB9 RHBDF2 HHAT CERS3	1.01e-07	1327	35	13	GO:0042175
GeneOntologyCellularComponent	monoatomic ion channel complex	LRRC8B KCNJ5 KCNJ9 KCNK10	3.54e-03	378	35	4	GO:0034702
Domain	Lag1/Lac1	CERS2 CERS5 CERS1 CERS3	1.37e-10	6	34	4	IPR016439
Domain	TLC	CERS2 CERS5 CERS1 CERS3	1.64e-08	16	34	4	PS50922
Domain	TRAM_LAG1_CLN8	CERS2 CERS5 CERS1 CERS3	1.64e-08	16	34	4	PF03798
Domain	TLC-dom	CERS2 CERS5 CERS1 CERS3	1.64e-08	16	34	4	IPR006634
Domain	TLC	CERS2 CERS5 CERS1 CERS3	1.64e-08	16	34	4	SM00724
Domain	Valyl-tRNA_ligase	VARS2 VARS1	3.22e-06	2	34	2	IPR002303
Domain	Anticodon_Ia_Val	VARS2 VARS1	3.22e-06	2	34	2	IPR033705
Domain	Val/Leu/Ile-tRNA-synth_edit	VARS2 VARS1	4.80e-05	6	34	2	IPR009008
Domain	M/V/L/I-tRNA-synth_anticd-bd	VARS2 VARS1	4.80e-05	6	34	2	IPR013155
Domain	-	VARS2 VARS1	4.80e-05	6	34	2	3.90.740.10
Domain	Anticodon_1	VARS2 VARS1	4.80e-05	6	34	2	PF08264
Domain	aa-tRNA-synth_Ia	VARS2 VARS1	6.72e-05	7	34	2	IPR002300
Domain	tRNA-synt_1	VARS2 VARS1	6.72e-05	7	34	2	PF00133
Domain	FA_desaturase_dom	DEGS2 SCD5	8.95e-05	8	34	2	IPR005804
Domain	FA_desaturase	DEGS2 SCD5	8.95e-05	8	34	2	PF00487
Domain	-	VARS2 VARS1	1.75e-04	11	34	2	1.10.730.10
Domain	tRNAsynth_Ia_anticodon-bd	VARS2 VARS1	3.33e-04	15	34	2	IPR009080
Domain	K_chnl_inward-rec_Kir_cyto	KCNJ5 KCNJ9	3.80e-04	16	34	2	IPR013518
Domain	IRK	KCNJ5 KCNJ9	3.80e-04	16	34	2	PF01007
Domain	-	KCNJ5 KCNJ9	3.80e-04	16	34	2	2.60.40.1400
Domain	K_chnl_inward-rec_Kir	KCNJ5 KCNJ9	3.80e-04	16	34	2	IPR016449
Domain	aa-tRNA-synth_I_CS	VARS2 VARS1	4.83e-04	18	34	2	IPR001412
Domain	AA_TRNA_LIGASE_I	VARS2 VARS1	5.39e-04	19	34	2	PS00178
Domain	Ig_E-set	SEC63 KCNJ5 KCNJ9	8.85e-04	104	34	3	IPR014756
Domain	Rossmann-like_a/b/a_fold	VARS2 VARS1	2.77e-03	43	34	2	IPR014729
Domain	-	VARS2 VARS1	2.77e-03	43	34	2	3.40.50.620
Domain	Homeobox	CERS2 CERS5 CERS3	8.73e-03	234	34	3	PF00046
Domain	HOMEOBOX_1	CERS2 CERS5 CERS3	8.93e-03	236	34	3	PS00027
Domain	HOX	CERS2 CERS5 CERS3	9.03e-03	237	34	3	SM00389
Domain	Homeobox_dom	CERS2 CERS5 CERS3	9.24e-03	239	34	3	IPR001356
Domain	HOMEOBOX_2	CERS2 CERS5 CERS3	9.24e-03	239	34	3	PS50071
Domain	-	CERS2 CERS5 CERS3	1.46e-02	283	34	3	1.10.10.60
Pathway	WP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY	CERS2 CERS5 DEGS2 CERS1 CERS3	1.96e-09	26	30	5	M39784
Pathway	WP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY	CERS2 CERS5 DEGS2 CERS1 CERS3	1.96e-09	26	30	5	MM15892
Pathway	REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS	CERS2 CERS5 DEGS2 CERS1 CERS3	2.40e-09	27	30	5	MM14646
Pathway	REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS	CERS2 CERS5 DEGS2 CERS1 CERS3	1.28e-08	37	30	5	M554
Pathway	WP_SYNTHESIS_OF_CERAMIDES_AND_1DEOXYCERAMIDES	CERS2 CERS5 CERS1 CERS3	1.19e-07	22	30	4	M45544
Pathway	WP_SPHINGOLIPID_METABOLISM_OVERVIEW	CERS2 DEGS2 CERS1 CERS3	2.04e-07	25	30	4	MM15931
Pathway	REACTOME_METABOLISM_OF_LIPIDS	PI4K2A CERS2 CERS5 FAM120B DEGS2 CERS1 SCD5 PLEKHA8 CERS3 PLEKHA3 TGS1	2.13e-07	757	30	11	M27451
Pathway	WP_SPHINGOLIPID_METABOLISM_OVERVIEW	CERS2 DEGS2 CERS1 CERS3	2.83e-07	27	30	4	M39863
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	CERS2 CERS5 DEGS2 CERS1 CERS3	1.33e-06	92	30	5	MM15086
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	CERS2 CERS5 DEGS2 CERS1 CERS3	2.81e-06	107	30	5	M14857
Pathway	REACTOME_METABOLISM_OF_LIPIDS	PI4K2A CERS2 CERS5 DEGS2 CERS1 PLEKHA8 CERS3 PLEKHA3 TGS1	3.62e-06	620	30	9	MM15193
Pathway	WP_SPHINGOLIPID_PATHWAY	CERS2 CERS5 CERS3	3.40e-05	30	30	3	M39501
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	PI4K2A PLEKHA8 PLEKHA3	1.59e-04	50	30	3	MM14641
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	PI4K2A PLEKHA8 PLEKHA3	1.90e-04	53	30	3	M662
Pathway	KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	VARS2 VARS1	2.38e-04	11	30	2	M17946
Pathway	REACTOME_PI_METABOLISM	PI4K2A PLEKHA8 PLEKHA3	5.72e-04	77	30	3	MM14590
Pathway	REACTOME_PI_METABOLISM	PI4K2A PLEKHA8 PLEKHA3	7.38e-04	84	30	3	M676
Pathway	REACTOME_POTASSIUM_CHANNELS	KCNJ5 KCNJ9 KCNK10	1.15e-03	98	30	3	MM14545
Pathway	REACTOME_POTASSIUM_CHANNELS	KCNJ5 KCNJ9 KCNK10	1.33e-03	103	30	3	M1073
Pathway	REACTOME_ACTIVATION_OF_G_PROTEIN_GATED_POTASSIUM_CHANNELS	KCNJ5 KCNJ9	1.84e-03	30	30	2	MM14542
Pathway	REACTOME_INWARDLY_RECTIFYING_K_CHANNELS	KCNJ5 KCNJ9	2.49e-03	35	30	2	M1075
Pathway	REACTOME_INWARDLY_RECTIFYING_K_CHANNELS	KCNJ5 KCNJ9	2.64e-03	36	30	2	MM14544
Pubmed	Oxidized phospholipids induce ceramide accumulation in RAW 264.7 macrophages: role of ceramide synthases.	CERS2 CERS5 CERS1 CERS3	1.29e-11	6	35	4	23936132
Pubmed	Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.	CERS2 CERS5 CERS1 CERS3	1.29e-11	6	35	4	17977534
Pubmed	Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.	CERS2 CERS5 DEGS2 CERS1 CERS3	6.09e-11	27	35	5	25269881
Pubmed	Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.	CERS2 CERS5 CERS1 SCD5 CERS3	8.94e-11	29	35	5	38485951
Pubmed	Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.	CERS2 CERS5 CERS1	9.32e-09	5	35	3	15823095
Pubmed	Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region.	CERS2 CERS5 CERS3	9.32e-09	5	35	3	26887952
Pubmed	Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.	CERS2 CERS5 CERS1 CERS3	1.48e-08	27	35	4	23096701
Pubmed	Ceramide synthase 1 is regulated by proteasomal mediated turnover.	CERS5 CERS1	9.84e-07	2	35	2	19393694
Pubmed	CerS1 but Not CerS5 Gene Silencing, Improves Insulin Sensitivity and Glucose Uptake in Skeletal Muscle.	CERS5 CERS1	9.84e-07	2	35	2	35053322
Pubmed	Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency.	CERS2 CERS1	9.84e-07	2	35	2	27162368
Pubmed	Histological analyses by matrix-assisted laser desorption/ionization-imaging mass spectrometry reveal differential localization of sphingomyelin molecular species regulated by particular ceramide synthase in mouse brains.	CERS2 CERS1	9.84e-07	2	35	2	26398595
Pubmed	Loss of ceramide synthase 3 causes lethal skin barrier disruption.	CERS2 CERS3	9.84e-07	2	35	2	22038835
Pubmed	Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity.	CERS5 CERS1	9.84e-07	2	35	2	16951403
Pubmed	Identification of GIRK2-4 subunits in human esophageal smooth muscle cells.	KCNJ5 KCNJ9	2.95e-06	3	35	2	21637918
Pubmed	FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P.	PLEKHA8 PLEKHA3	2.95e-06	3	35	2	15107860
Pubmed	Eleven residues determine the acyl chain specificity of ceramide synthases.	CERS2 CERS5	2.95e-06	3	35	2	29632068
Pubmed	Activation of SIRT1 Enhances Epidermal Permeability Barrier Formation through Ceramide Synthase 2- and 3-Dependent Mechanisms.	CERS2 CERS3	2.95e-06	3	35	2	31958434
Pubmed	CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance.	CERS5 CERS1	2.95e-06	3	35	2	30605666
Pubmed	Hyperalgesia and blunted morphine analgesia in G protein-gated potassium channel subunit knockout mice.	KCNJ5 KCNJ9	2.95e-06	3	35	2	12499858
Pubmed	Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.	CERS2 CERS5	2.95e-06	3	35	2	20406683
Pubmed	Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels.	KCNJ5 KCNJ9	5.90e-06	4	35	2	7499385
Pubmed	Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines.	KCNJ5 KCNJ9	5.90e-06	4	35	2	16109170
Pubmed	SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY.	CERS2 CERS1	5.90e-06	4	35	2	26620563
Pubmed	Functional analysis of the weaver mutant GIRK2 K+ channel and rescue of weaver granule cells.	KCNJ5 KCNJ9	5.90e-06	4	35	2	8630252
Pubmed	Do longevity assurance genes containing Hox domains regulate cell development via ceramide synthesis?	CERS5 CERS3	5.90e-06	4	35	2	12297269
Pubmed	Structural characterization of the mouse Girk genes.	KCNJ5 KCNJ9	5.90e-06	4	35	2	11891065
Pubmed	Co-expression of human Kir3 subunits can yield channels with different functional properties.	KCNJ5 KCNJ9	5.90e-06	4	35	2	10659995
Pubmed	Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors.	CERS5 CERS3	5.90e-06	4	35	2	12912983
Pubmed	Cell type-specific subunit composition of G protein-gated potassium channels in the cerebellum.	KCNJ5 KCNJ9	5.90e-06	4	35	2	18088366
Pubmed	Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells.	KCNJ5 KCNJ9	9.82e-06	5	35	2	19558451
Pubmed	PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels.	CERS2 CERS5	9.82e-06	5	35	2	38961186
Pubmed	Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain.	KCNJ5 KCNJ9	9.82e-06	5	35	2	7926018
Pubmed	The inward rectifier potassium channel family.	KCNJ5 KCNJ9	1.47e-05	6	35	2	7580148
Pubmed	Sex-specific perturbation of complex lipids in response to medium-chain fatty acids in very long-chain acyl-CoA dehydrogenase deficiency.	CERS2 CERS5	2.06e-05	7	35	2	31971349
Pubmed	Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis.	CERS2 CERS5	2.74e-05	8	35	2	36543979
Pubmed	G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase.	KCNJ5 KCNJ9	3.53e-05	9	35	2	12297500
Pubmed	Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production.	CERS2 CERS3	5.38e-05	11	35	2	23689133
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	CERS2 PAQR6 CERS1 GPAA1 KCNJ5 NDFIP1	6.27e-05	697	35	6	28298427
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	PI4K2A CERS2 PDPR GPAA1 RHBDF2 TMTC4 NDFIP1	7.68e-05	1061	35	7	33845483
Pubmed	Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS.	VARS2 VARS1	8.89e-05	14	35	2	15779907
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	CERS2 CERS1 SCD5 SEC63 PLEKHA8	1.00e-04	468	35	5	31056421
Pubmed	International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.	KCNJ5 KCNJ9	1.02e-04	15	35	2	16382105
Pubmed	Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains.	PI4K2A SCD5	1.33e-04	17	35	2	17496333
Pubmed	Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities.	PLEKHA8 PLEKHA3	1.33e-04	17	35	2	11001876
Pubmed	On the integration of alcohol-related quantitative trait loci and gene expression analyses.	SCD5 KCNJ9	1.49e-04	18	35	2	15597075
Pubmed	PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier.	CERS2 CERS3	1.66e-04	19	35	2	28369476
Pubmed	Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.	CERS2 VARS1 RNF146 CERS3	2.08e-04	292	35	4	12819125
Pubmed	Rare independent mutations in renal salt handling genes contribute to blood pressure variation.	KCNJ5 KCNJ9	2.24e-04	22	35	2	18391953
Pubmed	TIM-1 Ubiquitination Mediates Dengue Virus Entry.	PI4K2A NDFIP1	2.46e-04	23	35	2	29742433
Pubmed	β-dystroglycan is regulated by a balance between WWP1-mediated degradation and protection from WWP1 by dystrophin and utrophin.	PI4K2A NDFIP1	2.68e-04	24	35	2	29635000
Pubmed	Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins.	KCNJ5 KCNJ9	2.91e-04	25	35	2	17185339
Pubmed	NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation.	GPAA1 NDFIP1	3.40e-04	27	35	2	28931009
Pubmed	Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10.	KCNJ5 KCNJ9	4.49e-04	31	35	2	15921521
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	CERS2 CERS5 VARS2 PDPR GPAA1 SEC63 VARS1	5.22e-04	1451	35	7	30550785
Pubmed	Transcriptome analysis of human gastric cancer.	CERS2 DEGS2 SEC63 PLEKHA3 TGS1	9.94e-04	772	35	5	16341674
Interaction	DRD2 interactions	CERS2 PAQR6 CERS1 KCNJ5 KCNJ9 NDFIP1	1.88e-08	114	31	6	int:DRD2
Interaction	TSPAN3 interactions	PI4K2A LRRC8B RHBDF2 NDFIP1	1.69e-05	101	31	4	int:TSPAN3
GeneFamily	CERS class homeoboxes	CERS2 CERS5 CERS1 CERS3	6.89e-11	6	28	4	530
GeneFamily	Fatty acid desaturases	DEGS2 SCD5	6.44e-05	8	28	2	553
GeneFamily	Potassium voltage-gated channel subfamily J	KCNJ5 KCNJ9	2.74e-04	16	28	2	276
GeneFamily	Aminoacyl tRNA synthetases, Class I	VARS2 VARS1	3.89e-04	19	28	2	131
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	VARS2 ABCB9 TMTC4 VARS1	9.18e-06	169	35	4	c6e5b179461996ced6c7621dc01cec00d401f4e8
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_2\|368C / Donor, Lineage, Cell class and subclass (all cells)	ABCB9 RHBDF2 TMTC4 VARS1	9.62e-06	171	35	4	26b34dc069cc15b75a0c13cb8c5d81e074788160
ToppCell	proximal-Epithelial-Ionocyte\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ANO4 MFSD6L SCD5 HHAT	1.68e-05	197	35	4	e5d5accefaacea5ed2e22f906f5bcbc75083f287
ToppCell	proximal-Epithelial-Ionocyte-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ANO4 MFSD6L SCD5 HHAT	1.68e-05	197	35	4	f65c35761da7c168d5c6e4d7edf5dafa26652fe4
ToppCell	proximal-3-Epithelial-Ionocyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ANO4 MFSD6L SCD5 HHAT	1.68e-05	197	35	4	288492fc67d8e81349d38e82caf1f1890276b299
Disease	combined oxidative phosphorylation deficiency 20 (implicated_via_orthology)	VARS2 VARS1	1.37e-06	2	35	2	DOID:0111478 (implicated_via_orthology)
Disease	myoclonic-atonic epilepsy (implicated_via_orthology)	VARS2 VARS1	2.86e-05	7	35	2	DOID:0060475 (implicated_via_orthology)
Disease	mitochondrial encephalomyopathy (implicated_via_orthology)	VARS2 VARS1	3.81e-05	8	35	2	DOID:890 (implicated_via_orthology)
Disease	granulocyte count	SCD5 KCNJ9 NDFIP1 TGS1	2.28e-04	254	35	4	EFO_0007987
Disease	X-11470 measurement	VARS2 VARS1	2.31e-04	19	35	2	EFO_0021241
Disease	nose morphology measurement, mouth morphology measurement	ANO4 KCNK10	2.83e-04	21	35	2	EFO_0007843, EFO_0007955
Disease	gestational age, parental genotype effect measurement	VARS2 VARS1	7.94e-04	35	35	2	EFO_0005112, EFO_0005939
Disease	mitochondrial metabolism disease (implicated_via_orthology)	VARS2 VARS1	7.94e-04	35	35	2	DOID:700 (implicated_via_orthology)
Disease	squamous cell lung carcinoma	VARS2 VARS1 NDFIP1	9.85e-04	165	35	3	EFO_0000708
Disease	neutrophil count, eosinophil count	SCD5 NDFIP1 TGS1	2.05e-03	213	35	3	EFO_0004833, EFO_0004842
Disease	Moderate albuminuria	VARS2 VARS1	4.08e-03	80	35	2	HP_0012594
Disease	longitudinal BMI measurement	HHAT NDFIP1	4.28e-03	82	35	2	EFO_0005937
Disease	age of onset of childhood onset asthma	STAT5A NDFIP1	5.35e-03	92	35	2	OBA_2001015
Disease	attention deficit hyperactivity disorder	ANO4 MFSD6L GPR139	8.43e-03	354	35	3	EFO_0003888
Disease	platelet-to-lymphocyte ratio	VARS2 SCD5 VARS1	9.03e-03	363	35	3	EFO_0008446

Protein segments in the cluster

Peptide	Gene	Start	Entry
YECWASWGVWYKYQP	ANO4	321	Q32M45
YDYFWWERLWLPVNL	CERS2	6	Q96G23
PWFWDIRQCWHNYPF	CERS5	166	Q8N5B7
TWLFFGAIWWLIAYG	KCNJ9	71	Q92806
WLFFGFIWWLIAYIR	KCNJ5	101	P48544
GLYPCWLLFWNVLFW	GPAA1	606	O43292
LAGQLLYYSFLWSWW	MFSD6L	441	Q8IWD5
LYYSFLWSWWSVLPI	MFSD6L	446	Q8IWD5
LWPWWGEPIYRNGQY	PDPR	781	Q8NCN5
NYREWYKPLVWFWIL	KCNK10	291	P57789
YKWTNYLSGWQPRWF	PLEKHA8	6	Q96JA3
NIWTHFLPTWYFLWR	PAQR6	51	Q6TCH4
SYHILKPWWDVFWYY	LRRC8B	16	Q6P9F7
PDSWRAYPFYWAWLP	PI4K2A	356	Q9BTU6
GYDYLWCWAALNWLG	HHAT	381	Q5VTY9
GQYWLWWVFLVLGFL	NDFIP1	176	Q9BT67
KPWLYDLWEVWNGYP	CERS3	156	Q8IU89
DVVWLFLYVSIYWWG	MT-CO3	246	P00414
WRWLLFWAYAFGGCV	DEGS2	66	Q6QHC5
WFWFRLYWFPLKVLY	CERS1	251	P27544
FKWILFGHRPYWWVQ	G6PC2	71	Q9NQR9
IPYYWWPNIWTEDYI	GPR139	161	Q6DWJ6
YWYTPESWICGGQWR	FAM120B	51	Q96EK7
SPRYVEAAWYPWWEQ	VARS1	301	P26640
EAAWYPWWEQQGFFK	VARS1	306	P26640
PRYVEAAWYPWWVRE	VARS2	106	Q5ST30
WYYEGRNGWWQYDER	RNF146	106	Q9NTX7
LVPWYIWGESLWNSY	SCD5	206	Q86SK9
YLILYAAWLVLWVGW	NKAIN1	61	Q4KMZ8
ENLPGWNYTFWQWFD	STAT5A	561	P42229
IRDPWFWALFVWTYI	ABCB9	111	Q9NP78
YYSLNAWLLLCPWWL	TMTC4	321	Q5T4D3
WFLVTDWNPLTIWFY	TTLL8	411	A6PVC2
LYFPEEKQEWWWLYI	SEC63	641	Q9UGP8
YKWTNYLTGWQPRWF	PLEKHA3	6	Q9HB20
WYYLEQFQYWEAQGW	TGS1	246	Q96RS0
IWAIYWSAAGYWPLI	TRIM4	416	Q9C037
LWLYIYPINWPWIEH	RHBDF2	821	Q6PJF5