Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG-protein beta/gamma-subunit complex binding

GNA15 GNAI1 GNAI3

3.68e-0525523GO:0031683
GeneOntologyMolecularFunctionG protein-coupled serotonin receptor binding

GNAI1 GNAI3

6.62e-055522GO:0031821
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

CFTR PKD2 RYR3

8.60e-0533523GO:0005217
GeneOntologyMolecularFunctioncalcium-induced calcium release activity

PKD2 RYR3

9.91e-056522GO:0048763
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

TBC1D15 NF1 DOCK11 SIPA1L1 SIPA1L2 RALGAPA2 FARP2

3.25e-04507527GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

TBC1D15 NF1 DOCK11 SIPA1L1 SIPA1L2 RALGAPA2 FARP2

3.25e-04507527GO:0030695
GeneOntologyMolecularFunctionGTPase activator activity

TBC1D15 NF1 SIPA1L1 SIPA1L2 RALGAPA2

7.81e-04279525GO:0005096
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

PKD2 RYR3

9.91e-0418522GO:0015278
GeneOntologyMolecularFunctionATP-dependent activity

ABCA5 CFTR RFT1 RFC1 SMC5 DICER1 DNAH14

1.01e-03614527GO:0140657
GeneOntologyMolecularFunctionGTPase activating protein binding

GNAI1 GNAI3

1.11e-0319522GO:0032794
GeneOntologyMolecularFunctioncytoskeletal protein binding

TRIM2 NF1 VEZT SIPA1L1 PKD2 CKAP5 SNTG2 MAPK8IP3 FARP2

1.94e-031099529GO:0008092
GeneOntologyMolecularFunctionligand-gated calcium channel activity

PKD2 RYR3

2.95e-0331522GO:0099604
GeneOntologyCellularComponentheterotrimeric G-protein complex

GNA15 GNAI1 GNAI3

8.98e-0535523GO:0005834
GeneOntologyCellularComponentGTPase complex

GNA15 GNAI1 GNAI3

1.45e-0441523GO:1905360
GeneOntologyCellularComponentcytoplasmic side of membrane

PKD2 GNA15 GNAI1 GNAI3 RYR3

2.63e-04230525GO:0098562
GeneOntologyCellularComponentextrinsic component of cytoplasmic side of plasma membrane

GNA15 GNAI1 GNAI3

3.67e-0456523GO:0031234
GeneOntologyCellularComponentextrinsic component of plasma membrane

SCUBE2 GNA15 GNAI1 GNAI3

3.75e-04137524GO:0019897
GeneOntologyCellularComponentcytoplasmic side of plasma membrane

GNA15 GNAI1 GNAI3 RYR3

1.15e-03185524GO:0009898
DomainARM-type_fold

SMG1 NF1 MRO DOCK11 NBEAL2 LTN1 CKAP5 RALGAPA2 RYR3

3.56e-07339529IPR016024
DomainRap_GAP

SIPA1L1 SIPA1L2 RALGAPA2

2.41e-0610523PF02145
DomainRap_GAP_dom

SIPA1L1 SIPA1L2 RALGAPA2

3.31e-0611523IPR000331
DomainRAPGAP

SIPA1L1 SIPA1L2 RALGAPA2

3.31e-0611523PS50085
DomainG-alpha

GNA15 GNAI1 GNAI3

1.11e-0516523PF00503
DomainGproteinA_insert

GNA15 GNAI1 GNAI3

1.11e-0516523IPR011025
Domain-

GNA15 GNAI1 GNAI3

1.11e-05165231.10.400.10
DomainG_alpha

GNA15 GNAI1 GNAI3

1.11e-0516523SM00275
DomainGprotein_alpha_su

GNA15 GNAI1 GNAI3

1.35e-0517523IPR001019
DomainSPAR_C

SIPA1L1 SIPA1L2

2.28e-053522PF11881
DomainSIPA1L_C

SIPA1L1 SIPA1L2

2.28e-053522IPR021818
DomainPKD_2

PKD2L2 PKD2

7.56e-055522IPR003915
DomainARM-like

SMG1 NF1 MRO NBEAL2 LTN1 CKAP5

1.01e-04270526IPR011989
Domain-

ABCA5 CFTR GNA15 GNAI1 GNAI3 RFC1 SMC5 DICER1 DNAH14

1.94e-047465293.40.50.300
DomainGprotein_alpha_I

GNAI1 GNAI3

2.11e-048522IPR001408
DomainPKD_channel

PKD2L2 PKD2

4.11e-0411522PF08016
DomainPKD1_2_channel

PKD2L2 PKD2

4.11e-0411522IPR013122
DomainP-loop_NTPase

ABCA5 CFTR GNA15 GNAI1 GNAI3 RFC1 SMC5 DICER1 DNAH14

4.99e-04848529IPR027417
DomainHEAT_REPEAT

SMG1 MRO CKAP5

9.77e-0470523PS50077
DomainSEC14

NF1 CLVS2

2.19e-0325522SM00516
DomainCRAL_TRIO

NF1 CLVS2

2.55e-0327522PS50191
DomainCRAL-TRIO_dom

NF1 CLVS2

2.74e-0328522IPR001251
DomainABC_transporter_CS

ABCA5 CFTR

6.10e-0342522IPR017871
DomainPH_dom-like

DOCK11 NBEAL2 PLEKHS1 SNTG2 FARP2

6.50e-03426525IPR011993
DomainPDZ

SIPA1L1 SNTG2 SIPA1L2

7.11e-03141523PF00595
DomainPH

DOCK11 PLEKHS1 SNTG2 FARP2

7.43e-03278524SM00233
DomainPH_DOMAIN

DOCK11 PLEKHS1 SNTG2 FARP2

7.52e-03279524PS50003
DomainAAA+_ATPase

ABCA5 CFTR RFC1

7.53e-03144523IPR003593
DomainAAA

ABCA5 CFTR RFC1

7.53e-03144523SM00382
DomainPH_domain

DOCK11 PLEKHS1 SNTG2 FARP2

7.61e-03280524IPR001849
DomainABC_tran

ABCA5 CFTR

7.90e-0348522PF00005
DomainABC_TRANSPORTER_2

ABCA5 CFTR

7.90e-0348522PS50893
DomainPDZ

SIPA1L1 SNTG2 SIPA1L2

8.11e-03148523SM00228
DomainABC_TRANSPORTER_1

ABCA5 CFTR

8.22e-0349522PS00211
PathwayPID_S1P_META_PATHWAY

GNA15 GNAI1 GNAI3

2.32e-0521383M155
PathwayPID_S1P_S1P2_PATHWAY

GNA15 GNAI1 GNAI3

3.52e-0524383M268
PathwayPID_S1P_S1P3_PATHWAY

GNA15 GNAI1 GNAI3

6.29e-0529383M55
PathwayWP_POLYCYSTIC_KIDNEY_DISEASE_PATHWAY

CFTR PKD2 GNAI1 GNAI3

7.77e-0585384M48315
PathwayREACTOME_SIGNAL_AMPLIFICATION

GNA15 GNAI1 GNAI3

9.32e-0533383MM15020
PathwayREACTOME_SIGNAL_AMPLIFICATION

GNA15 GNAI1 GNAI3

9.32e-0533383M9379
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

GNA15 GNAI1 GNAI3

1.54e-0439383MM14496
PathwayPID_ER_NONGENOMIC_PATHWAY

GNA15 GNAI1 GNAI3

1.67e-0440383M41
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PROK2_TO_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY

GNAI1 GNAI3

1.96e-048382M47642
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PROKR2_TO_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY

GNAI1 GNAI3

1.96e-048382M47643
PathwayPID_THROMBIN_PAR1_PATHWAY

GNA15 GNAI1 GNAI3

2.07e-0443383M238
PathwayKEGG_MEDICUS_REFERENCE_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY

GNAI1 GNAI3

2.52e-049382M47641
PathwayKEGG_MEDICUS_ENV_FACTOR_NICOTINE_NNK_TO_PI3K_SIGNALING_PATHWAY

GNAI1 GNAI3

3.83e-0411382M47797
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

GNA15 GNAI1 GNAI3

4.08e-0454383M26911
PathwayKEGG_MEDICUS_REFERENCE_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY

GNAI1 GNAI3

4.59e-0412382M47558
PathwayKEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY

GNAI1 GNAI3

4.59e-0412382M47559
PathwayWP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING

GNAI1 RYR3

5.42e-0413382M39589
PathwayPID_S1P_S1P4_PATHWAY

GNAI1 GNAI3

6.31e-0414382M64
PathwayREACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY

GNAI1 GNAI3

6.31e-0414382MM14669
PathwayREACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY

GNAI1 GNAI3

6.31e-0414382M750
PathwayPID_ENDOTHELIN_PATHWAY

GNA15 GNAI1 GNAI3

6.42e-0463383M8
PathwayPID_LYSOPHOSPHOLIPID_PATHWAY

GNA15 GNAI1 GNAI3

7.03e-0465383M15
PathwayREACTOME_OPIOID_SIGNALLING

GNA15 GNAI1 GNAI3

9.10e-0471383MM14491
PathwayKEGG_MEDICUS_REFERENCE_CX3CR1_GNAI_AC_PKA_SIGNALING_PATHWAY

GNAI1 GNAI3

9.38e-0417382M47544
PathwayPID_S1P_S1P1_PATHWAY

GNAI1 GNAI3

1.44e-0321382M103
PathwayWP_PKCGAMMA_CALCIUM_SIGNALING_IN_ATAXIA

GNA15 RYR3

1.58e-0322382M39795
PathwayREACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_12

GNAI1 GNAI3

1.58e-0322382MM15016
PathwayREACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_12

GNAI1 GNAI3

1.58e-0322382M841
PathwayWP_SIGNAL_TRANSDUCTION_OF_S1P_RECEPTOR

GNAI1 GNAI3

1.73e-0323382MM15952
PathwayREACTOME_OPIOID_SIGNALLING

GNA15 GNAI1 GNAI3

1.81e-0390383M6467
PathwayWP_G_PROTEIN_SIGNALING_PATHWAYS

GNA15 GNAI1 GNAI3

1.81e-0390383MM15882
PathwayWP_G_PROTEIN_SIGNALING

GNA15 GNAI1 GNAI3

1.86e-0391383M39426
PathwayWP_S1P_RECEPTOR_SIGNAL_TRANSDUCTION

GNAI1 GNAI3

2.04e-0325382M39384
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAI_AC_PKA_SIGNALING_PATHWAY

GNAI1 GNAI3

2.21e-0326382M47553
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_RASD1_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY

GNAI1 GNAI3

2.38e-0327382M47519
PathwayPID_CXCR4_PATHWAY

CSK GNAI1 GNAI3

2.44e-03100383M124
PathwayPID_CDC42_REG_PATHWAY

DOCK11 FARP2

2.93e-0330382M83
PathwayPID_AR_NONGENOMIC_PATHWAY

GNAI1 GNAI3

3.13e-0331382M213
Pubmed

Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1).

GNA15 GNAI1 GNAI3

1.42e-061552311118617
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

TBCCD1 TBC1D15 CSK LTN1 CKAP5 GNAI1 GNAI3 SIPA1L2 PRPF8 DICER1

1.54e-06974521028675297
Pubmed

The human genome encodes at least three non-allellic G proteins with alpha i-type subunits.

GNAI1 GNAI3

2.19e-0625222440724
Pubmed

CFTR and PC2, partners in the primary cilia in autosomal dominant polycystic kidney disease.

CFTR PKD2

2.19e-06252237519231
Pubmed

Requirement of Gαi1 and Gαi3 in interleukin-4-induced signaling, macrophage M2 polarization and allergic asthma response.

GNAI1 GNAI3

2.19e-06252233754034
Pubmed

Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins.

GNAI1 GNAI3

6.57e-06352216962188
Pubmed

The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.

GNAI1 GNAI3

6.57e-0635228626678
Pubmed

Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteins.

GNAI1 GNAI3

6.57e-06352215788486
Pubmed

Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteins.

GNAI1 GNAI3

6.57e-06352217484771
Pubmed

Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K+ currents in adult murine atria.

GNAI1 GNAI3

6.57e-06352229342363
Pubmed

Polycystin-2 expression and function in adult mouse lacrimal acinar cells.

PKD2L2 PKD2

6.57e-06352221508103
Pubmed

Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy.

GNAI1 GNAI3

6.57e-0635228504751
Pubmed

GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2.

GNAI1 GNAI3

6.57e-06352230836096
Pubmed

Antidepression action of BDNF requires and is mimicked by Gαi1/3 expression in the hippocampus.

GNAI1 GNAI3

6.57e-06352229507199
Pubmed

RapGAPs in brain: multipurpose players in neuronal Rap signalling.

SIPA1L1 SIPA1L2

6.57e-06352220576033
Pubmed

Gαi1 and Gαi3mediate VEGF-induced VEGFR2 endocytosis, signaling and angiogenesis.

GNAI1 GNAI3

6.57e-06352230279732
Pubmed

G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development.

GNA15 GNAI1 GNAI3

1.01e-05285238858601
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

CLPTM1L LTN1 CKAP5 PRPF8 DICER1

1.31e-0520252533005030
Pubmed

Most central nervous system D2 dopamine receptors are coupled to their effectors by Go.

GNAI1 GNAI3

1.31e-05452211248120
Pubmed

Gαi1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis.

GNAI1 GNAI3

1.31e-05452237153740
Pubmed

RGS10 is a selective activator of G alpha i GTPase activity.

GNAI1 GNAI3

1.31e-0545228774883
Pubmed

Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division.

GNAI1 GNAI3

1.31e-05452217635935
Pubmed

Mouse gene knockout and knockin strategies in application to alpha subunits of Gi/Go family of G proteins.

GNAI1 GNAI3

1.31e-05452211771389
Pubmed

Gαi1 and Gαi3 regulate macrophage polarization by forming a complex containing CD14 and Gab1.

GNAI1 GNAI3

1.31e-05452225825741
Pubmed

CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains.

GNAI1 GNAI3

1.31e-05452211168387
Pubmed

Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling.

GNAI1 GNAI3

1.31e-05452212379657
Pubmed

Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells.

GNAI1 GNAI3

1.31e-0545221902575
Pubmed

The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics.

GNAI1 GNAI3

1.31e-05452218832081
Pubmed

Analysis of RGSZ1 protein interaction with Galphai subunits.

GNAI1 GNAI3

1.31e-05452215488169
Pubmed

Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP.

GNAI1 GNAI3

1.31e-05452210364213
Pubmed

Specific interaction of Gαi3 with the Oa1 G-protein coupled receptor controls the size and density of melanosomes in retinal pigment epithelium.

GNAI1 GNAI3

1.31e-05452221931697
Pubmed

Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via Gαi1,2,3.

GNAI1 GNAI3

1.31e-05452228145731
Pubmed

GIV/Girdin activates Gαi and inhibits Gαs via the same motif.

GNAI1 GNAI3

1.31e-05452227621449
Pubmed

Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.

NEMP1 CLPTM1L VEZT CKAP5 RFT1 PRPF8

2.02e-0537552632788342
Pubmed

Polycystin channels and kidney disease.

PKD2L2 PKD2

2.19e-05552211698076
Pubmed

Oxidized human neuroglobin acts as a heterotrimeric Galpha protein guanine nucleotide dissociation inhibitor.

GNAI1 GNAI3

2.19e-05552212860983
Pubmed

Coupling of dopamine receptor subtypes to multiple and diverse G proteins.

GNAI1 GNAI3

2.19e-05552210978845
Pubmed

Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes.

GNA15 GNAI1

2.19e-05552210973974
Pubmed

An essential role for Gα(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland.

GNAI1 GNAI3

2.19e-05552226373672
Pubmed

G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2).

GNAI1 GNAI3

2.19e-05552216298104
Pubmed

Defective macrophage migration in Gαi2- but not Gαi3-deficient mice.

GNAI1 GNAI3

2.19e-05552222706085
Pubmed

Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.

GNAI1 GNAI3

2.19e-0555222820999
Pubmed

GINIP, a Gαi-interacting protein, functions as a key modulator of peripheral GABAB receptor-mediated analgesia.

GNAI1 GNAI3

2.19e-05552225242222
Pubmed

Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-α interactions with G protein-αi and caveolin I.

GNAI1 GNAI3

2.19e-05552222230296
Pubmed

RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity.

GNAI1 GNAI3

2.19e-05552211387333
Pubmed

HIV-1 triggers WAVE2 phosphorylation in primary CD4 T cells and macrophages, mediating Arp2/3-dependent nuclear migration.

GNAI1 GNAI3

2.19e-05552224415754
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

SMG1 NEMP1 SIPA1L1 SMC5 DICER1

2.20e-0522552512168954
Pubmed

METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.

CKAP5 GNAI1 GNAI3 PRPF8 RYR3

2.49e-0523152536597993
Pubmed

Requirement of Gαi1/3-Gab1 signaling complex for keratinocyte growth factor-induced PI3K-AKT-mTORC1 activation.

GNAI1 GNAI3

3.28e-05652225078664
Pubmed

Identification of the platelet ADP receptor targeted by antithrombotic drugs.

GNAI1 GNAI3

3.28e-05652211196645
Pubmed

Gialpha and Gbeta subunits both define selectivity of G protein activation by alpha2-adrenergic receptors.

GNAI1 GNAI3

3.28e-05652216371464
Pubmed

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.

GNAI1 GNAI3

3.28e-05652218434541
Pubmed

Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins.

GNAI1 GNAI3

3.28e-05652223236180
Pubmed

Galpha(i1) and Galpha(i3) are required for epidermal growth factor-mediated activation of the Akt-mTORC1 pathway.

GNAI1 GNAI3

3.28e-05652219401591
Pubmed

Intrinsic planar polarity mechanisms influence the position-dependent regulation of synapse properties in inner hair cells.

GNAI1 GNAI3

3.28e-05652230975754
Pubmed

Cloning and characterization of a novel regulator of G protein signalling in human platelets.

GNAI1 GNAI3

3.28e-05652211955952
Pubmed

Characterization of RGS5 in regulation of G protein-coupled receptor signaling.

GNAI1 GNAI3

3.28e-05652211253162
Pubmed

CCL3, acting via the chemokine receptor CCR5, leads to independent activation of Janus kinase 2 (JAK2) and Gi proteins.

GNAI1 GNAI3

4.58e-05752215251452
Pubmed

Activation state-dependent interaction between Galphai and p67phox.

GNAI1 GNAI3

4.58e-05752216782902
Pubmed

GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits.

GNAI1 GNAI3

4.58e-0575228986788
Pubmed

Evolution of the mammalian G protein alpha subunit multigene family.

GNA15 GNAI1 GNAI3

5.53e-05495231302014
Pubmed

Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor.

GNAI1 GNAI3

6.10e-05852212509430
Pubmed

Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling.

GNAI1 GNAI3

6.10e-05852226126266
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

TMEM184A SH3TC1 VEZT PKD2 TTC14 SNTG2 VPS54 DNAH14 MAPK8IP3 FARP2

6.14e-051489521028611215
Pubmed

Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis.

GNAI1 GNAI3

7.84e-05952238651641
Pubmed

Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells.

PKD2L2 PKD2

9.79e-051052216805797
Pubmed

The LGN protein promotes planar proliferative divisions in the neocortex but apicobasal asymmetric terminal divisions in the retina.

GNAI1 GNAI3

9.79e-051052226755700
Pubmed

The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.

GNAI1 GNAI3

9.79e-05105228552586
Pubmed

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2.

GNAI1 GNAI3

9.79e-05105228521505
Pubmed

Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients.

CFTR RYR3

1.20e-041152219096130
Pubmed

Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse.

GNAI1 GNAI3

1.43e-04125222508088
Pubmed

Expression of adenylyl cyclase mRNAs in the denervated and in the developing mouse skeletal muscle.

GNAI1 GNAI3

1.43e-04125229611134
Pubmed

RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao.

GNAI1 GNAI3

1.43e-041252210926822
Pubmed

Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein.

GNAI1 GNAI3

1.69e-04135228208289
Pubmed

Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins.

GNAI1 GNAI3

1.69e-041352216892066
Pubmed

A molecular blueprint at the apical surface establishes planar asymmetry in cochlear hair cells.

GNAI1 GNAI3

1.69e-041352224135232
Pubmed

Isoforms of mammalian adenylyl cyclase: multiplicities of signaling.

GNAI1 GNAI3

1.97e-041452214993377
Pubmed

Large-scale concatenation cDNA sequencing.

NF1 CSK PKD2 GNAI1 RALGAPA2 DICER1

1.99e-045685269110174
Pubmed

A "double adaptor" method for improved shotgun library construction.

NF1 CSK PKD2 GNAI1 RALGAPA2 DICER1

2.10e-045745268619474
Pubmed

G proteins Gαi1/3 are critical targets for Bordetella pertussis toxin-induced vasoactive amine sensitization.

GNAI1 GNAI3

2.27e-041552224478091
Pubmed

Mechanism of GTP hydrolysis by G-protein alpha subunits.

GNA15 GNAI1

2.27e-04155227937899
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

SMG1 CLPTM1L TBC1D15 SIPA1L1 TRAPPC6B LTN1 RFC1 PRPF8 DICER1

2.57e-04144052930833792
Pubmed

Signaling mechanism of HIV-1 gp120 and virion-induced IL-1beta release in primary human macrophages.

GNAI1 GNAI3

2.94e-041752218453587
Pubmed

The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse.

CFTR PKD2

2.94e-041752216472605
Pubmed

Wilms Tumor Predisposition

NF1 DICER1

3.30e-041852220301471
Pubmed

Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression.

CLPTM1L TBC1D15 SIPA1L1 GNAI1 RFC1

3.39e-0440352535253629
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SIPA1L1 CKAP5 URB2 SIPA1L2 SMC5

3.54e-0440752512693553
Pubmed

Proteostasis is essential during cochlear development for neuron survival and hair cell polarity.

NF1 GNAI3

3.69e-041952231321879
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

NF1 CKAP5 URB2 RFC1 PRPF8 DICER1

4.19e-0465352622586326
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

CLPTM1L TBC1D15 NF1 LTN1 CKAP5 PRPF8

4.32e-0465752636180527
Pubmed

Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.

NF1 FARP2

4.52e-042152225340873
Pubmed

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

NF1 SIPA1L1 CFTR SIPA1L2 SMC5

4.55e-0443052532581705
Pubmed

Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.

CKAP5 SIPA1L2

4.97e-042252220694011
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

TRIM2 NBEAL2 SMC5

5.31e-041055239628581
Pubmed

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.

CLPTM1L TBC1D15 CSK VEZT DICER1 FARP2

5.43e-0468652628380382
Pubmed

Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human.

GNAI1 GNAI3

5.93e-04245222902634
Pubmed

Comparative analysis of 1196 orthologous mouse and human full-length mRNA and protein sequences.

NF1 CFTR

6.43e-04255228889551
Pubmed

5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.

SMG1 NF1

7.51e-042752223027611
Pubmed

An introduction to TRP channels.

PKD2L2 PKD2

7.51e-042752216460286
Pubmed

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.

CKAP5 SNTG2

7.51e-042752218468998
InteractionGARNL3 interactions

SIPA1L1 SIPA1L2 RALGAPA2

5.78e-0614523int:GARNL3
InteractionRALGAPA2 interactions

CSK SIPA1L1 SIPA1L2 RALGAPA2

7.05e-0648524int:RALGAPA2
InteractionS1PR1 interactions

TBC1D15 PKD2 CKAP5 GNAI1 GNAI3

1.02e-05112525int:S1PR1
InteractionRGS16 interactions

CSK GNAI1 GNAI3

1.07e-0517523int:RGS16
InteractionCNR1 interactions

GNA15 GNAI1 GNAI3

1.29e-0518523int:CNR1
InteractionRGS7 interactions

CSK GNAI1 GNAI3

3.58e-0525523int:RGS7
InteractionHRH4 interactions

GNA15 GNAI1

6.50e-055522int:HRH4
InteractionC19orf38 interactions

NF1 CFTR LTN1 CKAP5

7.16e-0586524int:C19orf38
GeneFamilyTransient receptor potential cation channels

PKD2L2 PKD2

9.79e-0428302249
GeneFamilyPDZ domain containing

SIPA1L1 SNTG2 SIPA1L2

2.00e-031523031220
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

DOCK11 PLEKHS1 FARP2

4.72e-03206303682
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

SH3TC1 TTC14

1.55e-02115302769
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

SMG1 NF1 DOCK11 SIPA1L1 CKAP5 RALGAPA2 PRPF8

6.61e-08180527M8239
CoexpressionGSE20152_SPHK1_KO_VS_HTNFA_OVEREXPRESS_ANKLE_UP

VEZT CFTR LTN1 VPS54 DICER1 MAPK8IP3

2.55e-06197526M7682
CoexpressionGSE24671_CTRL_VS_BAKIMULC_INFECTED_MOUSE_SPLENOCYTES_UP

SH3TC1 CSK DOCK11 SIPA1L1 DICER1

4.78e-05200525M9447
CoexpressionGSE11961_MEMORY_BCELL_DAY40_VS_GERMINAL_CENTER_BCELL_DAY40_DN

SH3TC1 ACO1 GNA15 PRPF8 FARP2

4.78e-05200525M9382
ToppCellASK454-Epithelial-Secretory|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

TBCCD1 NF1 ABCA5 ACO1 SIPA1L2

2.89e-06191525c63c781e7e93265e591cf494cb4ce8ed797c24fb
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_1|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SH3TC1 NBEAL2 GNA15 BTLA TVP23A

3.12e-061945255a048bd2af30975fdc57ff40bc49aa5811c830d8
ToppCelldistal-2-Hematologic-Myeloid_Dendritic_Type_1|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NEMP1 SIPA1L1 GNA15 BTLA TVP23A

3.53e-0619952586ee039189c75e66b97453c20a34d7fb5a31e51d
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PLEKHS1 CAMK1G RALGAPA2 RYR3

2.42e-0514452408005be9e3367f78ef27e125d9cce5ca53f4bd2d
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SH3TC1 NBEAL2 BTLA TVP23A

4.52e-0516952446f0f0de9a0894c454f93032e7a7a800f47c8276
ToppCellT_cells-Tph_and_Tfh|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

BTNL8 GNA15 BTLA SIPA1L2

5.29e-0517652456c055488e34605d32562571a2fee621b47c9441
ToppCell3'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-cDC1|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CSK NBEAL2 GNA15 BTLA

5.29e-0517652487f90834c7278516beff7814b78f7c75732d9bf0
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA5 CFTR PLEKHS1 SIPA1L2

5.29e-05176524c2c4306476989bc2fb30dab00250ef7915842f13
ToppCellRV-11._Adipocyte|World / Chamber and Cluster_Paper

DOCK11 ACO1 SNTG2 GNAI1

5.41e-05177524f0edf04930692418953e4f00a917257804ec0ffd
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SMG1 TRIM2 TMEM184A PLEKHS1

5.65e-051795246e965e424eebef50f0202cff75f458be395cfca1
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

TRIM2 SCUBE2 TMEM184A CFTR

5.77e-05180524b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCellCOVID-19-Epithelial-Ionocytes|Epithelial / Condition, Lineage and Cell class

SCUBE2 SH3TC1 CFTR URB2

5.90e-051815244a8d4f2709c1b25f908867f1b2fae1d2d0abf1d4
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c11-MKI67-FOS|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CLPTM1L PKD2 CKAP5 RFT1

6.16e-05183524ba7753e9fe2a6a87c5264f299ac97da2ddbda178
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SCUBE2 GNA15 BTLA TVP23A

6.29e-051845244f4aeef3b821a003e857fe4a195124d44b2d7479
ToppCellfacs-Trachea-24m-Epithelial-glandular_epithelial|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM184A CFTR PLEKHS1 SNTG2

6.29e-0518452461caaa31975e05c9a6512079c791fed5a9e2d39f
ToppCellCOPD-Myeloid-cDC1|World / Disease state, Lineage and Cell class

GNA15 BTLA TVP23A FARP2

6.29e-0518452442d7ce104cd7bcb83fbbbd0e7d3267ad07edfa94
ToppCellfacs-Trachea-24m-Epithelial-glandular_epithelial-lung_secretory_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM184A CFTR PLEKHS1 SNTG2

6.29e-0518452403da0f0f89f1ca5a3ccca1e22972f3129464e68e
ToppCellfacs-Trachea-24m-Epithelial-glandular_epithelial-lung_secretory_cell-mucous|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM184A CFTR PLEKHS1 SNTG2

6.29e-051845249ed2a65a4ca0ebbbb89ace61027522f93369843d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRIM2 ABCA5 CFTR SIPA1L2

6.56e-05186524a6ef5d5944af5689b5f27bef89cd05645eedbe50
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRIM2 ABCA5 CFTR SIPA1L2

6.83e-05188524e751cff2ac8fbc1487766c1871fcc5d1005286b0
ToppCellAdult-Epithelial-club_cell|Adult / Lineage, Cell type, age group and donor

TRIM2 SCUBE2 CFTR PLEKHS1

7.12e-05190524756bff697d30aec56c0ebfca94295f084a15bf37
ToppCellEpithelial-club_cell|World / Lineage, Cell type, age group and donor

TRIM2 SCUBE2 CFTR PLEKHS1

7.56e-051935242bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_1|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CSK GNA15 BTLA TVP23A

8.35e-0519852433690e16e4549b110e5b67f84b9515c696fe05e1
ToppCell5'-Adult-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCUBE2 NBEAL2 MYOM3 PLEKHS1

8.51e-05199524f544229f471b4717166dd4b588399afe45cc31b5
ToppCelldistal-Hematologic-Myeloid_Dendritic_Type_1-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NEMP1 SIPA1L1 GNA15 TVP23A

8.51e-0519952478e70852acda95d2c770cdd539a46b291f929a78
Diseaseduodenal ulcer (implicated_via_orthology)

ACO1 CFTR

8.78e-063512DOID:1724 (implicated_via_orthology)
Diseasepolycystic kidney disease 2 (implicated_via_orthology)

PKD2L2 PKD2

8.78e-063512DOID:0110859 (implicated_via_orthology)
DiseaseMcCune Albright syndrome (implicated_via_orthology)

GNAI1 GNAI3

8.15e-058512DOID:1858 (implicated_via_orthology)
Diseaseautosomal dominant polycystic kidney disease (implicated_via_orthology)

PKD2L2 PKD2

2.63e-0414512DOID:898 (implicated_via_orthology)
DiseaseAmnesia

GNAI1 GNAI3

3.92e-0417512C0002622
DiseaseTactile Amnesia

GNAI1 GNAI3

3.92e-0417512C0750906
DiseaseAmnestic State

GNAI1 GNAI3

3.92e-0417512C0750907
DiseaseDissociative Amnesia

GNAI1 GNAI3

3.92e-0417512C0236795
DiseaseGlobal Amnesia

GNAI1 GNAI3

3.92e-0417512C0262497
DiseaseHysterical amnesia

GNAI1 GNAI3

3.92e-0417512C0233750
DiseaseTemporary Amnesia

GNAI1 GNAI3

3.92e-0417512C0233796
DiseaseInfiltrating duct carcinoma of female breast

SMG1 CAMK1G

6.02e-0421512C3165106
Diseaseintelligence, response to cranial radiation therapy

TRIM2 SNTG2

1.08e-0328512EFO_0004337, EFO_0010950
Diseasecardiovascular age measurement

PKD2L2 SIPA1L1

1.15e-0329512EFO_0803380

Protein segments in the cluster

PeptideGeneStartEntry
WKKIEKFTAQFSSLG

URB2

656

Q14146
TFKKILNTKEFWSFI

ABCA5

1126

Q8WWZ7
DKLFFWNSKSTYIKS

ACO1

631

P21399
LEKASVVSKLFFSWT

CFTR

6

P13569
QTSWKEEKNISFFIL

BTLA

86

Q7Z6A9
IVGLKIFFSKFQWKI

BTNL8

251

Q6UX41
FSFWQEKILKTRKDF

ADAM7

271

Q9H2U9
KKFSTKSDVWSFGIL

CSK

361

P41240
FGWKKSIDSKSFISI

DICER1

1096

Q9UPY3
KLTWSFFKQSFLKQI

RFT1

241

Q96AA3
NKWFTDTSIILFLNK

GNAI1

256

P63096
WKLILTFFKAASSQL

LTN1

1481

O94822
WKVRKSFFKLQGSFD

LBP

116

P18428
FFTELEKTTLKFIWN

nan

836

O00370
EKKKSTIWQFFSRLF

MAPK8IP3

566

Q9UPT6
NKWFTETSIILFLNK

GNAI3

256

P08754
SIWNFFSSFLKEKLN

NEMP1

111

O14524
AFAGRKWKKFFTSQV

MRO

161

Q9BYG7
WFKSTSVILFLNKTD

GNA15

266

P30679
WIVTFFLEKKYLTAT

RALGAPA2

306

Q2PPJ7
SWKKQTTNIRKTFIF

CAMK1G

11

Q96NX5
WSKFLGLIKKFVTDS

CKAP5

46

Q14008
KLLKYSWFFFEIIAK

DOCK11

956

Q5JSL3
WLRLFQKTFQDTFKK

DGAT2L6

241

Q6ZPD8
TKIIQKLFVFAFTWA

DNAH14

1761

Q0VDD8
KINTFNWSKVRKLSF

FARP2

261

O94887
AFTSRSKKLWIQFKS

SCUBE2

891

Q9NQ36
TIKKETDVFWKSLDF

RFC1

541

P35251
LKFLTIKAVIFLSFW

TMEM184A

256

Q6ZMB5
WLKAFVGAFKKSISL

NBEAL2

26

Q6ZNJ1
SYEAEKIFKWIFSKF

SMG1

226

Q96Q15
KIFKWIFSKFSSSAK

SMG1

231

Q96Q15
ASDKLKKFTEWVFNT

SIPA1L1

1786

O43166
QLRKFTEWFFTTIDK

SIPA1L2

1706

Q9P2F8
IVVTFKTFEEIWKFS

SH3TC1

141

Q8TE82
SKTKNVLWRFKFSQL

SNTG2

456

Q9NY99
DFLAFKNDISFWKKK

CLPTM1L

301

Q96KA5
IIDWSNFTFKQASKL

CLVS2

161

Q5SYC1
FKATKFFQSTKLDWV

PRPF8

476

Q6P2Q9
SSVTSWKKRFFILSK

PLEKHS1

31

Q5SXH7
TAKELVKVLFSFFWM

RYR3

4176

Q15413
KFICKDFWTTVFKKQ

TRAPPC6B

66

Q86SZ2
SNRFKTDFLSKWFVV

NF1

1651

P21359
KFISKKADLLFALSW

TTC14

66

Q96N46
TNFKSIRSITDFWKF

PKD2L2

76

Q9NZM6
IIAITIFFAWIKIFK

PKD2L2

371

Q9NZM6
WSFLFSLTDLKSIKQ

TBC1D15

126

Q8TC07
IAAVTVFFVWIKLFK

PKD2

561

Q13563
KISKTFSFYKLETWL

TBCCD1

246

Q9NVR7
IVFFFSTLFSLKLKW

TVP23A

136

A6NH52
LKVAETIKSWIFFSQ

VEZT

61

Q9HBM0
WVSIFSSDGKFKTKI

TRIM2

556

Q9C040
QSFWFINKKSTTQKI

SMC5

146

Q8IY18
QWFDLLKDIFSKFTI

VPS54

446

Q9P1Q0
KVTNTKKETRFQWFF

MYOM3

1141

Q5VTT5