Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-8 ERVK-7 ERVK-10 ERVK-11

3.26e-0911374GO:0004523
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-8 ERVK-19 ERVK-7 ERVK-25 ERVK-10

6.89e-0937375GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-8 ERVK-19 ERVK-7 ERVK-25 ERVK-10

7.92e-0938375GO:0070001
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-8 ERVK-7 ERVK-10 ERVK-11

9.85e-0914374GO:0003964
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-8 ERVK-7 ERVK-10 ERVK-11

5.84e-0821374GO:0035613
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-8 ERVK-7 ERVK-10 ERVK-11

6.31e-0737374GO:0016891
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-8 ERVK-7 ERVK-10 ERVK-11

7.04e-0738374GO:0034061
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-8 ERVK-7 ERVK-10 ERVK-11

1.54e-0646374GO:0016893
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-8 ERVK-7 ERVK-10 ERVK-11

1.36e-0579374GO:0004521
GeneOntologyMolecularFunctionRNA nuclease activity

ERVK-8 ERVK-7 ERVK-10 ERVK-11

1.14e-04136374GO:0004540
GeneOntologyMolecularFunctionendonuclease activity

ERVK-8 ERVK-7 ERVK-10 ERVK-11

1.14e-04136374GO:0004519
GeneOntologyMolecularFunctionnucleotidyltransferase activity

ERVK-8 ERVK-7 ERVK-10 ERVK-11

1.75e-04152374GO:0016779
GeneOntologyMolecularFunctionnuclease activity

ERVK-8 ERVK-7 ERVK-10 ERVK-11

8.54e-04231374GO:0004518
GeneOntologyMolecularFunctioncatalytic activity, acting on RNA

ERVK-8 ERVK-7 ERVK-10 ERVK-11 THUMPD3

9.75e-04417375GO:0140098
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

ERVK-8 ZNFX1 ERVK-7 ERVK-10 ERVK-11 THUMPD3

1.10e-03645376GO:0140640
GeneOntologyMolecularFunctionendopeptidase activity

ERVK-8 ERVK-19 ERVK-7 ERVK-25 ERVK-10

1.12e-03430375GO:0004175
GeneOntologyMolecularFunctiontransition metal ion binding

ERVK-8 ERVK-19 ZNFX1 MTARC2 ERVK-7 ERVK-10 ERVK-11 OGFOD2

1.27e-031189378GO:0046914
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

ERVK-8 ERVK-7 ERVK-10 ERVK-11

1.36e-03262374GO:0140097
GeneOntologyMolecularFunctionpotassium channel regulator activity

LRRC55 SGK3

5.00e-0357372GO:0015459
GeneOntologyMolecularFunctionzinc ion binding

ERVK-8 ERVK-19 ZNFX1 ERVK-7 ERVK-10 ERVK-11

5.52e-03891376GO:0008270
GeneOntologyMolecularFunctionpeptidase activity

ERVK-8 ERVK-19 ERVK-7 ERVK-25 ERVK-10

6.80e-03654375GO:0008233
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

ERVK-8 NEK2 ERVK-7 ERVK-10 ERVK-11 SGK3

7.06e-03938376GO:0016772
GeneOntologyBiologicalProcessDNA integration

ERVK-8 ERVK-7 ERVK-10 ERVK-11

5.52e-0913364GO:0015074
GeneOntologyBiologicalProcessRNA-templated DNA biosynthetic process

ERVK-8 NEK2 ERVK-7 ERVK-10 ERVK-11

3.19e-0783365GO:0006278
GeneOntologyBiologicalProcessDNA synthesis involved in DNA repair

ERVK-8 ERVK-7 ERVK-10 ERVK-11

1.44e-0648364GO:0000731
GeneOntologyBiologicalProcessDNA biosynthetic process

ERVK-8 NEK2 ERVK-7 ERVK-10 ERVK-11

3.64e-05218365GO:0071897
GeneOntologyBiologicalProcessferroptosis

TMEM164 SLC7A11

1.32e-0410362GO:0097707
GeneOntologyBiologicalProcessregulation of ferroptosis

TMEM164 SLC7A11

1.32e-0410362GO:0110075
GeneOntologyBiologicalProcessviral process

ERVK-8 ERVK-19 ZNFX1 ERVK-7 ERVK-10 CR1

1.38e-04464366GO:0016032
GeneOntologyBiologicalProcessDNA-templated DNA replication

ERVK-8 ERVK-7 ERVK-10 ERVK-11

2.55e-04178364GO:0006261
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-8 ERVK-19 ERVK-7 ERVK-25 ERVK-10 ERVK-11

7.20e-109437621542922
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-25 ERVK-10 ERVK-11

8.94e-071837318664271
Pubmed

Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.

ERVK-19 ERVK-10

6.60e-0643727983737
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-7 ERVK-10

6.60e-06437210469592
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-19 ERVK-7

1.10e-05537212629516
Pubmed

Mapping of six dominant cataract genes in the mouse.

EDAR SGK3

6.02e-05113728034315
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-8 ERVK-19

7.22e-051237214557543
Pubmed

GWAS of dental caries patterns in the permanent dentition.

PHTF2 DYM

8.80e-044137223064961
Pubmed

The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta.

NODAL OGFOD2

1.01e-034437220178780
CytobandEnsembl 112 genes in cytogenetic band chr16q24

PIEZO1 FOXL1

5.14e-03136362chr16q24
GeneFamilyGuanylate cyclase receptors|DENN/MADD domain containing

FNIP2 SBF2

2.46e-0425172504
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

DOK6 SBF2

1.57e-02206172682
ToppCellcontrol-Myeloid-Eosinophils|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PHTF2 MTARC2 TMEM164 OR11A1 PTGDR2

1.69e-07184315fad517d047e8eaeaa5bd4f311d770880568dd13c
ToppCellcontrol-Myeloid-Eosinophils|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

MTARC2 TMEM164 OR11A1 PTGDR2

5.85e-0617131482f736c33ed96c0865618e8f8eb82a5487126bdc
ToppCell10x5'v1-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast-basophil|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MTARC2 TMEM164 CR1 PTGDR2

6.41e-06175314ba1befc4e5f0167452f9ceace39377d16136dfa9
Disease

CR1 TIRAP

1.27e-0416312611162
DiseaseMalaria, susceptibility to

CR1 TIRAP

1.27e-0416312cv:C1970028
DiseaseMalaria

CR1 TIRAP

2.01e-0420312C0024530
Diseasemalaria (is_implicated_in)

CR1 TIRAP

2.91e-0424312DOID:12365 (is_implicated_in)
DiseaseAmphetamine Abuse

MTARC2 MYO5B

2.83e-0375312C0236807
DiseaseAmphetamine Addiction

MTARC2 MYO5B

2.83e-0375312C0236804
DiseaseAmphetamine-Related Disorders

MTARC2 MYO5B

2.83e-0375312C0236733

Protein segments in the cluster

PeptideGeneStartEntry
MINISIGYRYPPICL

ERVK-19

151

O71037
MINISIGYRYPPICL

ERVK-8

151

Q902F8
RYLPRGMCIYLDPKE

CCDC187

791

A0A096LP49
YLGMPGCLPVYDALA

ERP29

151

P30040
YMCTYAPLKPDLALL

AP4B1

71

Q9Y6B7
RFLQPLMALLYPDCG

OGFOD2

196

Q6N063
AICYPLHYPLLMGPR

OR11A1

126

Q9GZK7
PPGYLTCYMELQVLD

LRRC55

81

Q6ZSA7
MLNAREPICYPSLYE

MAGEA9

291

P43362
SLGCLLYELCALMPP

NEK2

201

P51955
MYSLCRSYPGLLVVP

SBF2

1146

Q86WG5
CLPGYYMLENRPRNI

EDAR

116

Q9UNE0
LYLMPLGIYSPCIQE

GDPD4

176

Q6W3E5
LGYLPLAMALPCSLL

MSLNL

641

Q96KJ4
MCYYNVLLLNPGPDR

PTGDR2

181

Q9Y5Y4
MINISIGYRYPPICL

ERVK-7

911

P63135
LYLPGMTISYICDPG

CR1

1866

P17927
VYLMPTPNLDIYGEC

DOK6

141

Q6PKX4
SISHKYLMRGPCLPY

DYM

196

Q7RTS9
YLMRGPCLPYTSKLV

DYM

201

Q7RTS9
MINISIGYRYPPICL

ERVK-25

151

P61570
SLLAGYCPTYMPDLV

FNIP2

946

Q9P278
YPDYCPLLIMTDASL

MTARC2

206

Q969Z3
LSLYAPLYMCGLLPA

HAS1

461

Q92839
PLYMCGLLPAKFLAL

HAS1

466

Q92839
ALAASPMLYLYGPER

FOXL1

11

Q12952
MINISIGYRYPPICL

HERVK_113

151

Q902F9
CLGAVLYEMLYGLPP

SGK3

346

Q96BR1
SPFRLYGLTMNPLLY

PHTF2

741

Q8N3S3
LAYMLSLYRDPLPRA

NODAL

41

Q96S42
GLIYLRYKCPDMHRP

SLC7A11

406

Q9UPY5
YMAGPLCKYLLDLLR

TMEM164

276

Q5U3C3
SFLVPYMLCRNLPYG

UBE4B

486

O95155
MINISIGYRYPPICL

ERVK-10

911

P10266
MINISIGYRYPPICL

ERVK-11

911

Q9UQG0
PRYLLMGGRYDFTPL

ZNFX1

546

Q9P2E3
TLAYGMLRLCDPLPY

THUMPD3

306

Q9BV44
GLSRAAYPPELRFMY

TIRAP

181

P58753
YQYLLCLGMPPALCI

PIEZO1

1051

Q92508
TVPCLPAYILYMCIR

MYO5B

1496

Q9ULV0