Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domain-

CLGN CANX

2.64e-0535622.10.250.10
DomainCALRETICULIN_REPEAT

CLGN CANX

2.64e-053562PS00805
DomainCalret/calnex

CLGN CANX

5.28e-054562IPR001580
DomainCALRETICULIN_1

CLGN CANX

5.28e-054562PS00803
DomainCALRETICULIN_2

CLGN CANX

5.28e-054562PS00804
DomainCalret/calnex_CS

CLGN CANX

5.28e-054562IPR018124
DomainREJ

PKD1L1 PKD1L2

5.28e-054562PS51111
DomainCalreticulin

CLGN CANX

5.28e-054562PF00262
DomainREJ_dom

PKD1L1 PKD1L2

5.28e-054562IPR014010
DomainCalreticulin/calnexin_P_dom

CLGN CANX

8.78e-055562IPR009033
DomainPKD/REJ-like

PKD1L1 PKD1L2

1.31e-046562IPR002859
DomainREJ

PKD1L1 PKD1L2

1.31e-046562PF02010
DomainPKD_channel

PKD1L1 PKD1L2

4.77e-0411562PF08016
DomainPKD1_2_channel

PKD1L1 PKD1L2

4.77e-0411562IPR013122
DomainLH2

PKD1L1 PKD1L2

1.31e-0318562SM00308
DomainPLAT

PKD1L1 PKD1L2

1.79e-0321562PS50095
Domain-

PKD1L1 PKD1L2

1.79e-03215622.60.60.20
DomainPLAT

PKD1L1 PKD1L2

1.79e-0321562PF01477
DomainPLAT/LH2_dom

PKD1L1 PKD1L2

1.79e-0321562IPR001024
DomainGPS

PKD1L1 PKD1L2

5.21e-0336562PS50221
DomainGPS

PKD1L1 PKD1L2

5.50e-0337562IPR000203
DomainC2

MYOF CC2D2A RPH3A

7.13e-03131563PF00168
DomainC2

MYOF CC2D2A RPH3A

8.06e-03137563SM00239
DomainC2

MYOF CC2D2A RPH3A

8.89e-03142563PS50004
Pubmed

Polycystin-1L2 is a novel G-protein-binding protein.

PKD1L1 PKD1L2

2.64e-06257215203210
Pubmed

Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment.

MYBPC1 MYBPC2

2.64e-0625728375400
Pubmed

Fast and slow skeletal myosin binding protein-C and aging.

MYBPC1 MYBPC2

2.64e-06257236409445
Pubmed

Molecular cloning and sequencing of calnexin-t. An abundant male germ cell-specific calcium-binding protein of the endoplasmic reticulum.

CLGN CANX

2.64e-0625728188695
Pubmed

Isoform-specific interaction of the myosin-binding proteins (MyBPs) with skeletal and cardiac myosin is a property of the C-terminal immunoglobulin domain.

MYBPC1 MYBPC2

2.64e-0625729252413
Pubmed

The C-terminal IgI domains of myosin-binding proteins C and H (MyBP-C and MyBP-H) are both necessary and sufficient for the intracellular crosslinking of sarcomeric myosin in transfected non-muscle cells.

MYBPC1 MYBPC2

7.91e-06357212154082
Pubmed

Direct recording and molecular identification of the calcium channel of primary cilia.

PKD1L1 PKD1L2

7.91e-06357224336289
Pubmed

AHNAK, a novel component of the dysferlin protein complex, redistributes to the cytoplasm with dysferlin during skeletal muscle regeneration.

MYOF AHNAK

1.58e-05457217185750
Pubmed

Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly.

FHL1 MYBPC1

1.58e-05457216407297
Pubmed

Epithelial development and differentiation in the mammary gland is not dependent on alpha 3 or alpha 6 integrin subunits.

MBD2 ITGB4

1.58e-05457211336507
Pubmed

Agrin has a pathological role in the progression of oral cancer.

MTHFD1 RPS3 CANX FHL1 MYBPC1

1.83e-0519757529872149
Pubmed

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

MYOF MTHFD1 AHNAK SMARCAL1 CANX U2SURP

1.99e-0534057624332808
Pubmed

Differential expression of C-protein isoforms in developing and degenerating mouse striated muscles.

MYBPC1 MYBPC2

2.63e-05557210024132
Pubmed

Isoform transitions of the myosin binding protein C family in developing human and mouse muscles: lack of isoform transcomplementation in cardiac muscle.

MYBPC1 MYBPC2

2.63e-0555729440711
Pubmed

N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.

ZDHHC6 AHNAK SMARCAL1 EXOC3 ZNF688

2.90e-0521757534048709
Pubmed

PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria.

AHNAK CANX ITGB4 CAP1

7.52e-0513657422304920
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

MTHFD1 AHNAK CANX IDH3A FHL1 ITGB4 CAP1

8.81e-0564757726618866
Pubmed

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.

UTP18 MTHFD1 CANX ZNF75D KATNA1 CAP1

9.54e-0545157636168627
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

UTP18 MTHFD1 RPS3 CANX U2SURP CC2D2A IDH3A FHL1 CAP1 MYBPC1

9.63e-051425571030948266
Pubmed

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.

RPS3 AHNAK TRIOBP FHL1 CAP1

1.05e-0428557521423176
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

DGLUCY UBA7 LRIG1 RPS3 AHNAK CANX U2SURP POMGNT1 IDH3A NDUFB6

1.12e-041451571030550785
Pubmed

Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells.

PKD1L1 PKD1L2

1.18e-041057216805797
Pubmed

PRMT7 methylates eukaryotic translation initiation factor 2α and regulates its role in stress granule formation.

PRMT8 RPS3

1.18e-041057230699057
Pubmed

Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability.

CLGN MTHFD1 CANX IDH3A

1.41e-0416057423798571
Pubmed

Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.

MTHFD1 RPS3 AHNAK CANX TRIOBP ITGB4

1.47e-0448857631324722
Pubmed

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

CLGN UTP18 MTHFD1 RPS3 AHNAK SLC43A1 CANX POMGNT1

1.54e-0495257838569033
Pubmed

Molecular diversity of myofibrillar proteins: gene regulation and functional significance.

MYBPC1 MYBPC2

1.72e-04125728618961
Pubmed

circFNDC3B Accelerates Vasculature Formation and Metastasis in Oral Squamous Cell Carcinoma.

RPS3 AHNAK CAP1

2.30e-047257336811957
Pubmed

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

MYOF MAN2C1 MTHFD1 CANX CAP1

2.53e-0434457530333137
Pubmed

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

UBA7 EXOC3 NXPE1

2.91e-047857321297633
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

MYOF MTHFD1 RPS3 AHNAK CANX PAPSS2 CAP1

3.40e-0480757730575818
Pubmed

Ski regulates Hippo and TAZ signaling to suppress breast cancer progression.

RPS3 AHNAK ITGB4

3.62e-048457325670202
Pubmed

Systematic Affinity Purification Coupled to Mass Spectrometry Identified p62 as Part of the Cannabinoid Receptor CB2 Interactome.

CLGN MTHFD1 CANX

3.62e-048457331616248
Pubmed

Quantitative analysis of PPT1 interactome in human neuroblastoma cells.

CLGN RPS3 AHNAK CANX

3.97e-0421057426217791
Pubmed

A Proteomic Variant Approach (ProVarA) for Personalized Medicine of Inherited and Somatic Disease.

CANX CAP1

4.43e-041957229924966
Pubmed

Abnormal Wnt and PI3Kinase signaling in the malformed intestine of lama5 deficient mice.

FHL1 ITGB4

4.43e-041957222666383
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

UTP18 RPS3 CANX U2SURP MBD2 ZNF687

4.62e-0460557628977666
Pubmed

SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.

MYOF MTHFD1 CANX U2SURP IDH3A FHL1

4.70e-0460757639147351
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

MTHFD1 CANX U2SURP TRIOBP IDH3A FHL1 RPH3A CAP1

5.14e-04113957836417873
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

MTHFD1 RPS3 AHNAK CANX U2SURP IDH3A FHL1 CAP1

5.44e-04114957835446349
Pubmed

USP45 and Spindly are part of the same complex implicated in cell migration.

MTHFD1 RPS3 AHNAK U2SURP

6.06e-0423557430258100
Pubmed

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.

UTP18 MTHFD1 RPS3 CANX U2SURP FHL1

6.26e-0464157636057605
Pubmed

The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells.

MTHFD1 AHNAK CANX CAP1

6.46e-0423957426641092
Pubmed

Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.

PRMT8 MTHFD1

6.53e-042357218320585
Pubmed

Genome-wide association with select biomarker traits in the Framingham Heart Study.

CLGN PTPRE

6.53e-042357217903293
Pubmed

BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny.

LRIG1 ITGB4

7.73e-042557223271346
Pubmed

The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4.

RPS3 AHNAK CAP1

7.95e-0411057318307411
Pubmed

Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.

RPS3 AHNAK CANX ITGB4

8.34e-0425657424189400
Pubmed

Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.

RPS3 CANX U2SURP CAP1

8.46e-0425757431046837
Pubmed

Phosphoproteomic analysis of the human pituitary.

RPS3 CAP1

9.02e-042757216807684
Pubmed

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

UBA7 MTHFD1 FHL1 CAP1

9.22e-0426357412665801
Pubmed

Mass spectrometry-based proteomics revealed Glypican-1 as a novel ADAM17 substrate.

CANX ITGB4 CAP1

9.28e-0411657327576135
Pubmed

A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.

AHNAK TRIOBP ITGB4

9.75e-0411857330979931
Pubmed

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.

MYOF MTHFD1 AHNAK CANX

9.88e-0426857433024031
Pubmed

Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation.

MTHFD1 RPS3 CANX IDH3A

1.00e-0326957430442662
Pubmed

CDK7/GRP78 signaling axis contributes to tumor growth and metastasis in osteosarcoma.

CDC42BPG MYOF SCN11A RPS3 CANX

1.02e-0346857536042349
Pubmed

Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation.

MTHFD1 RPS3 AHNAK CAP1

1.03e-0327157426816005
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

MTHFD1 RPS3 AHNAK CANX EXOC3 CAP1

1.05e-0370857639231216
Pubmed

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.

MTHFD1 RPS3 AHNAK CANX U2SURP

1.11e-0347757531300519
Pubmed

Upregulation of TIPE1 in tubular epithelial cell aggravates diabetic nephropathy by disrupting PHB2 mediated mitophagy.

RPS3 CANX

1.11e-033057235152003
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

UTP18 MTHFD1 RPS3 AHNAK CANX U2SURP MBD2

1.13e-0398957736424410
Pubmed

Comprehensive Proteomic Analysis of PGC7-Interacting Proteins.

CANX EXOC3 IDH3A FHL1

1.27e-0328757428712289
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

UTP18 MTHFD1 RPS3 AHNAK CANX U2SURP IDH3A ZNF687

1.32e-03131857830463901
Pubmed

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

PKD1L1 PKD1L2

1.35e-033357219834762
Pubmed

Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy.

UTP18 RPS3 CANX IDH3A

1.36e-0329257435545034
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

MTHFD1 RPS3 AHNAK CANX U2SURP EXOC3 IDH3A

1.38e-03102457724711643
Pubmed

The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.

RPS3 AHNAK CANX PAPSS2

1.46e-0329857430737378
Pubmed

Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking.

RPS3 CANX

1.52e-033557222337587
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

RPS3 CANX U2SURP ITGB4 CAP1

1.53e-0351357525798074
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

UTP18 MTHFD1 RPS3 AHNAK U2SURP EXOC3 PAPSS2 CAP1

1.56e-03135357829467282
Pubmed

TRIM37 Mediates Chemoresistance and Maintenance of Stemness in Pancreatic Cancer Cells via Ubiquitination of PTEN and Activation of the AKT-GSK-3β-β-Catenin Signaling Pathway.

MYOF RPS3 AHNAK CANX

1.59e-0330557433194618
Pubmed

Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy.

MYBPC1 MYBPC2

1.60e-033657223236519
Pubmed

Experimental and Computational Analysis of Newly Identified Pathogenic Mutations in the Creatine Transporter SLC6A8.

CLGN CANX

1.60e-033657238070861
Cytoband10q24

MYOF PAPSS2

8.78e-043557210q24
GeneFamilyFibronectin type III domain containing|I-set domain containing|Myosin binding proteins

MYBPC1 MYBPC2

1.26e-048392658
CoexpressionTOOKER_GEMCITABINE_RESISTANCE_DN

MTHFD1 TRIOBP IDH3A FHL1 PAPSS2

7.22e-06123575M18806
CoexpressionGSE9601_UNTREATED_VS_NFKB_INHIBITOR_TREATED_HCMV_INF_MONOCYTE_UP

MYOF FHL1 PAPSS2 ITGB4 HOXA2

2.99e-05165575M6880
CoexpressionGSE36888_STAT5_AB_KNOCKIN_VS_WT_TCELL_IL2_TREATED_2H_DN

NLRP12 SLC43A1 CANX TRIOBP CC2D2A

7.12e-05198575M8750
CoexpressionGSE24574_NAIVE_VS_TCONV_CD4_TCELL_DN

UTP18 CANX EXOC3 ZNF75D IDH3A

7.46e-05200575M8330
CoexpressionGSE360_CTRL_VS_L_DONOVANI_MAC_UP

UBA7 AHNAK SLC43A1 CAP1 MYBPC2

7.46e-05200575M5157
CoexpressionGSE360_L_MAJOR_VS_B_MALAYI_LOW_DOSE_DC_DN

MAN2C1 MTHFD1 AHNAK KATNA1 NDUFB6

7.46e-05200575M5212
CoexpressionGSE17721_PAM3CSK4_VS_GADIQUIMOD_1H_BMDC_DN

UTP18 CANX TRIOBP IDH3A ZNF688

7.46e-05200575M3963
CoexpressionTOMLINS_PROSTATE_CANCER_DN

MYOF FHL1 ITGB4

9.10e-0540573M11504
Drugtrifluoperazine dihydrochloride; Up 200; 10uM; HL60; HT_HG-U133A

SCN11A PARP3 TNFAIP6 PAPSS2 ITGB4 ZNF688

7.04e-061865762684_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT_HG-U133A

MYOF CLGN ZNF75D TNFAIP6 FHL1 PAPSS2

9.22e-061955762566_UP
DrugMethantheline bromide [53-46-3]; Up 200; 9.6uM; MCF7; HT_HG-U133A

MYOF UBA7 CLGN AHNAK SLC43A1 PAPSS2

1.04e-051995763560_UP
Diseaseinterleukin 18 measurement

NLRP12 SCN11A SLC43A1

3.91e-0476553EFO_0004581
DiseaseBell's palsy

NLRP12 SLC41A3 CC2D2A

9.23e-04102553EFO_0007167
Diseaseglutamate measurement

DGLUCY NDUFB6

1.34e-0329552EFO_0010487

Protein segments in the cluster

PeptideGeneStartEntry
FKWMDTGIAPPRPKI

ERVK13-1

136

Q9NX77
KKRMPEGPWPADAPS

FAM220A

31

Q7Z4H9
LGWVAMAPKPGPYVK

CAP1

141

Q01518
DMPEVAVEGPNGKWK

AHNAK

2356

Q09666
DVGVQGPDWHLKMPK

AHNAK

2626

Q09666
VGVQGPDWHLKMPKV

AHNAK

3011

Q09666
KWLKPGGLMFPDRAA

PRMT8

206

Q9NR22
MDLPFWKLPREPGKG

ASXL1

1406

Q8IXJ9
MKPVITCWNPKDPGG

CCDC60

176

Q8IWA6
LWASFGDPKKIPPPM

RRH

261

O14718
EGLGGDADPMKRKPW

CDC42BPG

1496

Q6DT37
WDFLPGLMVKAPSGP

NPAS1

26

Q99742
MAPKPKPWVQTEGPE

PARP3

1

Q9Y6F1
PPDGFMAPKAWKVLT

PAPSS2

591

O95340
WPDFGVPFTPIGMLK

PTPRE

301

P23469
EPWKAMEKAEGTPGP

LRIG1

906

Q96JA1
MVGPLKGEPFWVNLG

SLC43A1

501

O75387
PPQKMGPMEKFWNKF

NDUFB6

36

O95139
GPPLGFLDWVPKKMQ

MPPED1

246

O15442
NWLPPSGKPMGYRVK

ITGB4

1146

P16144
WGVPKDPAEQKMDLG

PKD1L2

1571

Q7Z442
SGKRMDCPALPPGWK

MBD2

146

Q9UBB5
KPPPGEGVTLWKGKM

CCDC105

86

Q8IYK2
PGLVKAPVWWPMKDN

FHL1

296

Q13642
IQGPGGKWMIPSEAK

IDH3A

71

P50213
KKAWLLMGNAIPEGP

CC2D2A

1381

Q9P2K1
DLIMGPNGKPSWDDK

CYP2R1

341

Q6VVX0
GKWKPPMIDNPSYQG

CANX

381

P27824
PWKRIEVMALPKPGG

MAN2C1

631

Q9NTJ4
PWKGVLMVGPPGTGK

KATNA1

241

O75449
GPLPLLGQSEPEKWM

DGLUCY

61

Q7Z3D6
VPPGRPKNWKEKMFT

EXOC3

236

O60645
AIPREMPGKGGVWKV

PNMA1

76

Q8ND90
MPGKGGVWKVLFKPP

PNMA1

81

Q8ND90
PPLVKNMGPGKVQIW

PKD1L1

676

Q8TDX9
TGQPEMVKGEWIKPG

MTHFD1

216

P11586
MKPPVPGGYTLQGKW

NXPE1

311

Q8N323
PAGALQPPEYPWMKE

HOXA2

86

O43364
RKPGMRPDWKAGAGP

UTP18

21

Q9Y5J1
WFFKGFPKQVLPQPM

RPH3A

156

Q9Y2J0
MDDWKPSPLIKPFGA

POMGNT1

1

Q8WZA1
GIWKKPEEMPTACPG

SMARCAL1

96

Q9NZC9
VKIMLPWDPTGKIGP

RPS3

186

P23396
APGVLPLQMKKFWPN

SLC41A3

346

Q96GZ6
KKGWMSILDEPGEPP

TRIOBP

1781

Q9H2D6
FEMKLGWGKAVPIPP

U2SURP

346

O15042
GEWKPPMIDNPKYKG

CLGN

356

O14967
MFVGPGFVPLGWKPE

ZDHHC6

76

Q9H6R6
WMAKGRVGYPIVKPG

TNFAIP6

86

P98066
VWSVGPPLKPLMFEK

UBA7

796

P41226
EPCMAKFGPLPSKWQ

TNFSF18

56

Q9UNG2
GFPGPKPALISWMEQ

ZNF688

66

P0C7X2
APGFKWKPAEPQPMG

ZNF75D

156

P51815
WKPAEPQPMGVFQKE

ZNF75D

161

P51815
PAPPSGGTWKEKGME

ZNF687

141

Q8N1G0
DGFGWLPEMVPKKQP

SCN11A

1001

Q9UI33
GKEPWMVKKEGTRGP

ZNF583

61

Q96ND8
MNRKDFVVLPWGKPG

ZBBX

1

A8MT70
GKIPWGSMEKAGPLE

NLRP12

41

P59046
QMWVDVFPKSLGPPG

MYOF

1761

Q9NZM1
GEPPPKAMWSRGDKA

MYBPC1

551

Q00872
ILVWEPPMYDGGKPV

MYBPC2

656

Q14324